Disease table of CORNELIA DE LANGE SYNDROME OMIM ID: PS122470

Gene-disease associations table

GeneAssociated with CORNELIA DE LANGE SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SMC1AClinVar, OMIM, HUMSAVARHGNC linkXp11.222605130, PS122470
TAF6ClinVarHGNC link7q22.11PS122470
KMT2AClinVarHGNC link11q23.32605130, PS122470
RAD21ClinVar, OMIM, HUMSAVARHGNC link8q24.111PS122470
HDAC8ClinVar, OMIM, HUMSAVARHGNC linkXq13.12PS309510, PS122470
SMC3ClinVar, OMIMHGNC link10q25.21PS122470
NIPBLClinVar, OMIM, HUMSAVARHGNC link5p13.21PS122470

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
X2SMC1A, HDAC8
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SOX4NO8HDAC8, NKX3-1, KMT2A, AGO1, DHX9, AXIN2, NCAM1, DICER12HDAC8, KMT2A
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
KMT2AYES1SOX40
RAD21YES1CTCF0
HDAC8YES1SOX40
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SMC1ATAF6No3NTRK1, USP37, SAP30
SMC1AKMT2ANo4SNW1, RNF2, SAP30, POLR2A
SMC1ARAD21Yes35STAG2, STAG1, PDS5A, AIRE, SMC3, NSMCE2, USP37, SNW1, SMC2, HIST1H3E, CTCF, PSMC2, ANKRD28, SSU72, RPA1, CHTF18, PDS5B, RPA2, BRCA1, RAD21, SMC1A, WAPAL, EED, RNF2, SMARCA5, CDCA5, MCM7, MSH6, SIRT6, SRRM1, WFDC5, NIPBL, RPA3, NTRK1, SMC4
SMC1AHDAC8Yes4MDC1, SMC1A, STAG2, SMC3
SMC1ASMC3Yes71ATM, STAG2, STAG1, CDK2, PDS5A, FOXB1, FOXL1, OBSL1, PAXIP1, CCDC8, NSMCE2, HDAC8, USP37, KSR1, SMARCAD1, RNF126, SDF4, MSH6, STAG3, HIST1H3E, CDC5L, PSMC2, CTCF, ANKRD28, SSU72, POLR2A, RPA1, CDK8, RAE1, PDS5B, FOXJ2, FBXO6, TEAD2, HDAC5, RAD21, RPGR, SYCP3, SIRT6, SMC1A, RPA2, FOXG1, EED, NUMA1, HDAC11, NOTCH1, RNF2, SMARCA5, CDCA5, CDK4, SNW1, RPA3, WFDC5, SMC2, BRCA1, SF3B3, NF2, BECN1, EGFR, CASP4, CAMKK2, USP13, SRRM1, PLK1, NIPBL, AIRE, CUL3, ESR1, NTRK1, METTL21B, WAPAL, CUL7
SMC1ANIPBLYes15CCDC8, OBSL1, RPA2, CDC5L, EED, SMC1A, SMC3, CDK8, SF3A2, USP37, RPA1, RPA3, SNW1, RAD21, BRCA1
TAF6KMT2AYes19SMARCC1, RAN, HIST3H3, TBP, HDAC2, HDAC1, SMARCA2, SMARCB1, KMT2A, TP53, TAF9, SMARCC2, RBBP7, MBD3, TAF1, SIN3A, RBBP4, CHD3, SAP30
TAF6RAD21No4NTRK1, RAN, USP37, CHD3
TAF6HDAC8No1HIST3H3
TAF6SMC3No5NTRK1, USP37, SUPT5H, HDAC2, SMARCA2
TAF6NIPBLNo1USP37
KMT2ARAD21No11RAN, RNF2, CHD3, CDK9, SIRT7, HECW2, PPP1R15A, EWSR1, SNW1, DYNLT1, HIST1H4A
KMT2AHDAC8No4HIST1H3A, HIST3H3, SVIL, HIST1H4A
KMT2ASMC3No6SMARCA2, HDAC2, RNF2, POLR2A, TAT, SNW1
KMT2ANIPBLNo5EWSR1, SNW1, MLLT3, CBX1, SIRT7
RAD21HDAC8No8HSP90AA1, SMC1A, HIST4H4, STAG2, SMC3, TPM3, HIST1H4A, DDB1
RAD21SMC3Yes36STAG2, STAG1, PDS5A, SMC1B, AIRE, NSMCE2, USP37, SNW1, SMC2, SFPQ, CTCF, PSMC2, ANKRD28, SSU72, RPA1, PDS5B, RPA2, BRCA1, KPNB1, SMC1A, DISC1, WAPAL, EED, HIST1H3E, RNF2, SMARCA5, CDCA5, MSH6, SIRT6, BRCA2, RAD21, SRRM1, WFDC5, NIPBL, RPA3, NTRK1
RAD21NIPBLYes13SMC1A, RPA2, EED, SIRT7, TFG, SMC3, USP37, RPA1, RPA3, EWSR1, BRCA1, RPL10, SNW1
HDAC8SMC3Yes2SMC1A, STAG2
HDAC8NIPBLNo2SMC1A, SMC3
SMC3NIPBLYes13CCDC8, SMC1A, RPA2, CDC5L, EED, OBSL1, RPA1, USP37, CDK8, RPA3, SNW1, RAD21, BRCA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TAF6RAD21No-1HIST3H3
TAF6SMC3No-1HIST3H3
RAD21SMC3Yesbinding118NDC80, PDS5A, CASC5, TERF1, ZW10, SYCE1, LMNB1, KIF18A, REC8, KIF2A, CENPL, NSL1, CENPF, SUN2, CENPM, PPP1CC, SEC13, BUB3, CENPH, MAD1L1, RANGAP1, AHCTF1, ERCC6L, RPS27, KIF2B, CLASP1, PLK1, ZWINT, BUB1B, CENPP, TAOK1, ACD, CENPN, ZWILCH, NUP160, NUP85, TERF2, CENPQ, SKA2, APITD1, MAPRE1, ESCO2, HSPA2, B9D2, CENPA, STAG1, RCC2, BUB1, H2AFX, SYCP3, SYCP1, SYNE2, SUN1, SPDL1, UBC, DSN1, MAU2, NDEL1, NUP37, TERF2IP, CENPC1, HIST3H3, STAG3, PAFAH1B1, SGOL2, PDS5B, CENPK, BRCA1, CDC20, RAD21L1, BIRC5, WAPAL, POT1, MLF1IP, SPC24, CDCA5, INCENP, SGOL1, SMC2, NUF2, CENPE, SYCE2, NIPBL, ITGB3BP, SMC4, STAG2, TEX12, CTCF, CKAP5, TINF2, XPO1, MAD2L1, RAD50, ESCO1, CENPI, KIF2C, AURKB, PMF1, ATR, SMC1B, CLIP1, ESPL1, NUP43, NUP133, KNTC1, NUP107, CENPT, CLASP2, CDCA8, NUDC, CENPO, SYNE1, WFDC5, NDE1, RANBP2, UBE2I, MIS12, SYCP2
RAD21NIPBLYesbinding11STAG3, MAU2, STAG1, PDS5A, SMC1B, STAG2, SMC3, REC8, PDS5B, WAPAL, RAD21L1
SMC3NIPBLYesbinding11STAG3, MAU2, STAG1, PDS5A, SMC1B, STAG2, REC8, PDS5B, WAPAL, RAD21, RAD21L1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
SMC1ATAF6No-8MBD3, HDAC1, HDAC2, RBBP7, SMARCA5, MTA2, RBBP4, CHD3
SMC1AKMT2ANo-8MBD3, HDAC1, HDAC2, RBBP7, SMARCA5, MTA2, RBBP4, CHD3
SMC1ARAD21YesSororin-cohesin complex;Mitotic 14S cohesin 1 complex;SNF2h-cohesin-NuRD complex;Mitotic 14S cohesin 2 complex;Cohesin-SA2 complex;Cohesin-SA1 complex;CDCA5-PDS5A-RAD21-SMC1A-PDS5B-SMC3 complex17STAG2, STAG1, PDS5A, HDAC1, HDAC2, MBD3, RBBP7, SMARCA5, BAZ1A, MTA1, CDCA5, SMC3, MTA2, PDS5B, RBBP4, CHD3, MBD2
SMC1ASMC3YesSororin-cohesin complex;Mitotic 14S cohesin 1 complex;SMC1-SMC3 complex;SNF2h-cohesin-NuRD complex;Mitotic 14S cohesin 2 complex;Cohesin-SA2 complex;Cohesin-SA1 complex;CDCA5-PDS5A-RAD21-SMC1A-PDS5B-SMC3 complex17STAG2, STAG1, PDS5A, RBBP4, HDAC1, HDAC2, MBD3, RBBP7, SMARCA5, BAZ1A, MTA1, CDCA5, MTA2, PDS5B, RAD21, CHD3, MBD2
TAF6KMT2AYesALL-1 supercomplex;MOF complex;MLL1-WDR5 complex50RBBP5, PELP1, TBP, SYMPK, CHD3, MGAM, CHD8, SAP30, HCFC1, TAF4, ASH2L, HSPA4, KDM1A, RUVBL1, TAF12, TAF7, INO80C, RBBP7, SMARCC2, CPSF2, LAS1L, MCRS1, SMARCB1, RAN, SENP3, SIN3A, HDAC1, TEX10, E2F6, C17ORF49, SMARCA5, PRPF31, BAP18, TAF1, MTA2, PHF20, KMT2D, SMARCC1, SMARCA2, RNF2, WDR5, HDAC2, TAF9, KAT8, SETD1A, MBD3, SAP18, KANSL1, RBBP4, EFTUD2
TAF6RAD21No-8MBD3, HDAC1, HDAC2, RBBP7, SMARCA5, MTA2, RBBP4, CHD3
TAF6SMC3No-8MBD3, HDAC1, HDAC2, RBBP7, SMARCA5, MTA2, RBBP4, CHD3
KMT2ARAD21No-8MBD3, HDAC1, HDAC2, RBBP7, SMARCA5, MTA2, RBBP4, CHD3
KMT2ASMC3No-8MBD3, HDAC1, HDAC2, RBBP7, SMARCA5, MTA2, RBBP4, CHD3
RAD21SMC3YesSororin-cohesin complex;Mitotic 14S cohesin 1 complex;SNF2h-cohesin-NuRD complex;Mitotic 14S cohesin 2 complex;Cohesin-SA2 complex;Cohesin-SA1 complex;CDCA5-PDS5A-RAD21-SMC1A-PDS5B-SMC3 complex17STAG2, STAG1, PDS5A, HDAC1, HDAC2, SMC1A, RBBP7, SMARCA5, BAZ1A, MTA1, CDCA5, MBD3, MTA2, PDS5B, RBBP4, CHD3, MBD2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SMC1ARAD21Yes1SMC3
SMC1ASMC3Yes1RAD21
SMC1ANIPBLNo1RAD21
TAF6KMT2AYes0
RAD21SMC3Yes1SMC1A
RAD21NIPBLYes0
SMC3NIPBLNo1RAD21

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Cell cyclehsa041105.683SMC1A, RAD21, SMC3
Oocyte meiosishsa041145.912SMC1A, SMC3

NET-GE enrichment

Term New enriched termICP valueGenes
Cell cycle (hsa04110) -5.680.003SMC1A, RAD21, SMC3
TranscriptionNEW5.070.041SMC1A, KMT2A, TAF6
Cell growth and deathNEW4.410.035SMC1A, RAD21, SMC3
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cell CycleR-HSA-16401703.895HDAC8, SMC1A, RAD21, NIPBL, SMC3
M PhaseR-HSA-688864.875HDAC8, SMC1A, RAD21, NIPBL, SMC3
Cell Cycle, MitoticR-HSA-692784.165HDAC8, SMC1A, RAD21, NIPBL, SMC3
Resolution of Sister Chromatid CohesionR-HSA-25002576.184HDAC8, SMC1A, RAD21, SMC3
Mitotic Metaphase and AnaphaseR-HSA-25553965.454HDAC8, SMC1A, RAD21, SMC3
Separation of Sister ChromatidsR-HSA-24678135.554HDAC8, SMC1A, RAD21, SMC3
Mitotic Telophase/CytokinesisR-HSA-688849.184SMC1A, RAD21, NIPBL, SMC3
Cohesin Loading onto ChromatinR-HSA-24709469.664SMC1A, RAD21, NIPBL, SMC3
Mitotic PrometaphaseR-HSA-688776.084HDAC8, SMC1A, RAD21, SMC3
Mitotic AnaphaseR-HSA-688825.464HDAC8, SMC1A, RAD21, SMC3
SUMOylation of DNA damage response and repair proteinsR-HSA-31082146.773SMC1A, RAD21, SMC3
SUMO E3 ligases SUMOylate target proteinsR-HSA-31082326.773SMC1A, RAD21, SMC3
Metabolism of proteinsR-HSA-3924993.413SMC1A, RAD21, SMC3
S PhaseR-HSA-692426.023SMC1A, RAD21, SMC3
MeiosisR-HSA-15006206.593SMC1A, RAD21, SMC3
Meiotic synapsisR-HSA-12216327.183SMC1A, RAD21, SMC3
SUMOylationR-HSA-29908466.683SMC1A, RAD21, SMC3
Establishment of Sister Chromatid CohesionR-HSA-24680529.523SMC1A, RAD21, SMC3
Post-translational protein modificationR-HSA-5975924.543SMC1A, RAD21, SMC3
Gene ExpressionR-HSA-741602.722SMC1A, TAF6
Chromatin organizationR-HSA-48397265.192HDAC8, KMT2A
DiseaseR-HSA-16436853.332HDAC8, TAF6
Chromatin modifying enzymesR-HSA-32475095.192HDAC8, KMT2A

NET-GE enrichment

Term New enriched termICP valueGenes
Establishment of Sister Chromatid Cohesion (R-HSA-2468052) -9.520.0SMC1A, RAD21, SMC3
SUMOylation of DNA damage response and repair proteins (R-HSA-3108214) -6.770.004SMC1A, RAD21, SMC3
Resolution of Sister Chromatid Cohesion (R-HSA-2500257) -6.180.0HDAC8, SMC1A, RAD21, SMC3
Mitotic Metaphase and Anaphase (R-HSA-2555396) -5.450.0HDAC8, SMC1A, RAD21, SMC3
Separation of Sister Chromatids (R-HSA-2467813) -5.550.001HDAC8, SMC1A, RAD21, SMC3
Meiosis (R-HSA-1500620) -6.590.002SMC1A, RAD21, SMC3
SUMO E3 ligases SUMOylate target proteins (R-HSA-3108232) -6.770.004SMC1A, RAD21, SMC3
S Phase (R-HSA-69242) -6.020.013SMC1A, RAD21, SMC3
M Phase (R-HSA-68886) -4.870.0HDAC8, SMC1A, RAD21, NIPBL, SMC3
Cell Cycle, Mitotic (R-HSA-69278) -4.160.004HDAC8, SMC1A, RAD21, NIPBL, SMC3
Meiotic synapsis (R-HSA-1221632) -7.180.001SMC1A, RAD21, SMC3
Mitotic Anaphase (R-HSA-68882) -5.460.0HDAC8, SMC1A, RAD21, SMC3
Mitotic Telophase/Cytokinesis (R-HSA-68884) -9.180.0SMC1A, RAD21, NIPBL, SMC3
Cell Cycle (R-HSA-1640170) -3.890.001HDAC8, SMC1A, RAD21, NIPBL, SMC3
Cohesin Loading onto Chromatin (R-HSA-2470946) -9.660.0SMC1A, RAD21, NIPBL, SMC3
Mitotic Prometaphase (R-HSA-68877) -6.080.0HDAC8, SMC1A, RAD21, SMC3
SUMOylation (R-HSA-2990846) -6.680.004SMC1A, RAD21, SMC3
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.187HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
protein binding (GO:0005515) 0.467HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
organic cyclic compound binding (GO:0097159) 1.054SMC3, SMC1A, KMT2A, TAF6
protein dimerization activity (GO:0046983) 2.724SMC1A, SMC3, TAF6, KMT2A
chromatin binding (GO:0003682) 3.644SMC1A, NIPBL, SMC3, KMT2A
macromolecular complex binding (GO:0044877) 2.614NIPBL, SMC1A, KMT2A, SMC3
heterocyclic compound binding (GO:1901363) 1.064SMC1A, SMC3, TAF6, KMT2A
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.653KMT2A, RAD21, TAF6
mediator complex binding (GO:0036033) 8.353SMC1A, NIPBL, SMC3
catalytic activity (GO:0003824) 1.053HDAC8, KMT2A, SMC3
nucleic acid binding transcription factor activity (GO:0001071) 2.653KMT2A, RAD21, TAF6
nucleic acid binding (GO:0003676) 1.443SMC1A, KMT2A, TAF6
protein complex binding (GO:0032403) 3.093SMC1A, NIPBL, SMC3
protein heterodimerization activity (GO:0046982) 3.643SMC1A, SMC3, TAF6
hydrolase activity (GO:0016787) 1.92HDAC8, SMC3
ion binding (GO:0043167) 1.362HDAC8, KMT2A
cation binding (GO:0043169) 1.42HDAC8, KMT2A
carbohydrate derivative binding (GO:0097367) 2.032SMC1A, SMC3
ribonucleoside binding (GO:0032549) 2.222SMC1A, SMC3
purine ribonucleoside triphosphate binding (GO:0035639) 2.222SMC1A, SMC3
nucleotide binding (GO:0000166) 1.962SMC1A, SMC3
small molecule binding (GO:0036094) 1.892SMC1A, SMC3
ribonucleotide binding (GO:0032553) 2.192SMC1A, SMC3
adenyl nucleotide binding (GO:0030554) 2.42SMC1A, SMC3
adenyl ribonucleotide binding (GO:0032559) 2.412SMC1A, SMC3
ATP binding (GO:0005524) 2.432SMC1A, SMC3
purine nucleoside binding (GO:0001883) 2.222SMC1A, SMC3
DNA binding (GO:0003677) 1.922KMT2A, TAF6
purine ribonucleotide binding (GO:0032555) 2.22SMC1A, SMC3
purine nucleotide binding (GO:0017076) 2.192SMC1A, SMC3
metal ion binding (GO:0046872) 1.412HDAC8, KMT2A
purine ribonucleoside binding (GO:0032550) 2.222SMC1A, SMC3
nucleoside phosphate binding (GO:1901265) 1.962SMC1A, SMC3
nucleoside binding (GO:0001882) 2.212SMC1A, SMC3

NET-GE enrichment

Term New enriched termICP valueGenes
structure-specific DNA binding (GO:0043566) NEW4.980.015SMC1A, SMC3, TAF6, KMT2A
chromatin binding (GO:0003682) -3.640.0SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
protein N-terminus binding (GO:0047485) NEW5.110.014NIPBL, SMC3, TAF6
sequence-specific DNA binding transcription factor activity (GO:0003700) -2.650.017HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
mediator complex binding (GO:0036033) -8.350.0SMC1A, NIPBL, SMC3
enzyme binding (GO:0019899) NEW2.270.004HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
histone binding (GO:0042393) NEW4.720.05KMT2A, RAD21, TAF6
nucleic acid binding transcription factor activity (GO:0001071) -2.650.017HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
serine-type endopeptidase inhibitor activity (GO:0004867) NEW5.160.022SMC1A, RAD21, SMC3
protein complex binding (GO:0032403) -3.090.009SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
protein dimerization activity (GO:0046983) -2.720.031SMC1A, SMC3, TAF6, KMT2A
protein heterodimerization activity (GO:0046982) -3.640.032SMC1A, RAD21, SMC3, TAF6, KMT2A
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of primary metabolic process (GO:0080090) 1.087HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of metabolic process (GO:0019222) 1.027HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.437HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.467HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of cellular metabolic process (GO:0031323) 1.077HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
cellular process (GO:0009987) 0.267HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of biosynthetic process (GO:0009889) 1.377HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of cellular process (GO:0050794) 0.57HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of macromolecule metabolic process (GO:0060255) 1.087HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of macromolecule biosynthetic process (GO:0010556) 1.437HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
biological regulation (GO:0065007) 0.397HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of nitrogen compound metabolic process (GO:0051171) 1.367HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of cellular biosynthetic process (GO:0031326) 1.387HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of biological process (GO:0050789) 0.457HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
cellular component organization (GO:0016043) 1.246HDAC8, SMC1A, KMT2A, SMC3, NIPBL, RAD21
primary metabolic process (GO:0044238) 0.696HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
cellular macromolecule metabolic process (GO:0044260) 0.936HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
nucleobase-containing compound metabolic process (GO:0006139) 1.356HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
cellular component organization or biogenesis (GO:0071840) 1.226HDAC8, SMC1A, KMT2A, SMC3, NIPBL, RAD21
cellular aromatic compound metabolic process (GO:0006725) 1.36HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
cellular metabolic process (GO:0044237) 0.696HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
macromolecule metabolic process (GO:0043170) 0.836HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
nucleic acid metabolic process (GO:0090304) 1.466HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
organic substance metabolic process (GO:0071704) 0.636HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
cellular nitrogen compound metabolic process (GO:0034641) 1.226HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
nitrogen compound metabolic process (GO:0006807) 1.136HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
organic cyclic compound metabolic process (GO:1901360) 1.266HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
metabolic process (GO:0008152) 0.586HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
negative regulation of biological process (GO:0048519) 1.336HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6
negative regulation of cellular process (GO:0048523) 1.416HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6
heterocycle metabolic process (GO:0046483) 1.316HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
organelle organization (GO:0006996) 2.025HDAC8, SMC1A, RAD21, NIPBL, SMC3
cellular protein metabolic process (GO:0044267) 1.635HDAC8, SMC1A, RAD21, KMT2A, SMC3
chromosome organization (GO:0051276) 3.795HDAC8, SMC1A, RAD21, NIPBL, SMC3
protein metabolic process (GO:0019538) 1.455HDAC8, SMC1A, RAD21, KMT2A, SMC3
response to stimulus (GO:0050896) 1.225NIPBL, SMC1A, RAD21, KMT2A, SMC3
regulation of RNA metabolic process (GO:0051252) 1.525HDAC8, NIPBL, RAD21, KMT2A, TAF6
cellular protein modification process (GO:0006464) 1.795HDAC8, SMC1A, RAD21, KMT2A, SMC3
regulation of transcription, DNA-templated (GO:0006355) 1.565HDAC8, NIPBL, RAD21, KMT2A, TAF6
macromolecule modification (GO:0043412) 1.735HDAC8, SMC1A, RAD21, KMT2A, SMC3
protein modification process (GO:0036211) 1.795HDAC8, SMC1A, RAD21, KMT2A, SMC3
single-organism cellular process (GO:0044763) 0.655SMC1A, RAD21, NIPBL, SMC3, KMT2A
regulation of nucleic acid-templated transcription (GO:1903506) 1.555HDAC8, KMT2A, RAD21, NIPBL, TAF6
regulation of RNA biosynthetic process (GO:2001141) 1.555HDAC8, KMT2A, RAD21, NIPBL, TAF6
cell cycle process (GO:0022402) 2.755HDAC8, SMC1A, RAD21, NIPBL, SMC3
regulation of gene expression (GO:0010468) 1.375HDAC8, KMT2A, RAD21, NIPBL, TAF6
single-organism process (GO:0044699) 0.485NIPBL, SMC1A, RAD21, KMT2A, SMC3
sister chromatid cohesion (GO:0007062) 5.035HDAC8, SMC1A, RAD21, NIPBL, SMC3
negative regulation of metabolic process (GO:0009892) 1.934HDAC8, SMC1A, NIPBL, SMC3
RNA biosynthetic process (GO:0032774) 1.844HDAC8, KMT2A, RAD21, TAF6
negative regulation of biosynthetic process (GO:0009890) 2.474HDAC8, SMC1A, NIPBL, SMC3
negative regulation of cellular biosynthetic process (GO:0031327) 2.494HDAC8, SMC1A, NIPBL, SMC3
negative regulation of cellular metabolic process (GO:0031324) 2.014HDAC8, SMC1A, NIPBL, SMC3
mitotic cell cycle process (GO:1903047) 3.124SMC1A, RAD21, NIPBL, SMC3
cellular biosynthetic process (GO:0044249) 1.374HDAC8, KMT2A, RAD21, TAF6
cell cycle phase (GO:0022403) 4.394HDAC8, SMC1A, RAD21, SMC3
cellular macromolecule biosynthetic process (GO:0034645) 1.664HDAC8, KMT2A, RAD21, TAF6
organic cyclic compound biosynthetic process (GO:1901362) 1.664HDAC8, KMT2A, RAD21, TAF6
nucleic acid-templated transcription (GO:0097659) 1.914HDAC8, KMT2A, RAD21, TAF6
organic substance biosynthetic process (GO:1901576) 1.344HDAC8, KMT2A, RAD21, TAF6
cellular response to stimulus (GO:0051716) 1.974SMC1A, RAD21, NIPBL, SMC3
negative regulation of macromolecule metabolic process (GO:0010605) 2.014HDAC8, SMC1A, NIPBL, SMC3
anaphase (GO:0051322) 4.74HDAC8, SMC1A, RAD21, SMC3
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.64HDAC8, SMC1A, NIPBL, SMC3
peptidyl-amino acid modification (GO:0018193) 2.984SMC1A, RAD21, KMT2A, SMC3
cell cycle (GO:0007049) 3.144SMC1A, RAD21, NIPBL, SMC3
heterocycle biosynthetic process (GO:0018130) 1.74HDAC8, KMT2A, RAD21, TAF6
developmental process (GO:0032502) 1.364NIPBL, SMC1A, KMT2A, SMC3
cytokinesis (GO:0000910) 5.224SMC1A, RAD21, NIPBL, SMC3
multicellular organismal process (GO:0032501) 1.454NIPBL, SMC1A, KMT2A, SMC3
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.554HDAC8, SMC1A, NIPBL, SMC3
biological phase (GO:0044848) 4.374HDAC8, SMC1A, RAD21, SMC3
mitotic anaphase (GO:0000090) 4.74HDAC8, SMC1A, RAD21, SMC3
single-organism developmental process (GO:0044767) 1.494NIPBL, SMC1A, KMT2A, SMC3
reproductive process (GO:0022414) 2.554SMC1A, RAD21, NIPBL, SMC3
biosynthetic process (GO:0009058) 1.324HDAC8, KMT2A, RAD21, TAF6
macromolecule biosynthetic process (GO:0009059) 1.614HDAC8, KMT2A, RAD21, TAF6
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.474HDAC8, SMC1A, NIPBL, SMC3
mitotic prometaphase (GO:0000236) 5.154HDAC8, SMC1A, RAD21, SMC3
nucleobase-containing compound biosynthetic process (GO:0034654) 1.724HDAC8, KMT2A, RAD21, TAF6
mitotic cell cycle phase (GO:0098763) 5.154HDAC8, SMC1A, RAD21, SMC3
RNA metabolic process (GO:0016070) 1.594HDAC8, KMT2A, RAD21, TAF6
cellular response to DNA damage stimulus (GO:0006974) 3.174SMC1A, RAD21, NIPBL, SMC3
cellular nitrogen compound biosynthetic process (GO:0044271) 1.594HDAC8, KMT2A, RAD21, TAF6
single-multicellular organism process (GO:0044707) 1.784NIPBL, KMT2A, SMC1A, SMC3
regulation of cell cycle (GO:0051726) 2.934HDAC8, SMC1A, TAF6, SMC3
peptidyl-lysine modification (GO:0018205) 3.984SMC1A, RAD21, KMT2A, SMC3
response to stress (GO:0006950) 1.84SMC1A, RAD21, NIPBL, SMC3
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.244HDAC8, KMT2A, RAD21, NIPBL
transcription, DNA-templated (GO:0006351) 1.914HDAC8, KMT2A, RAD21, TAF6
cellular response to stress (GO:0033554) 2.514SMC1A, RAD21, NIPBL, SMC3
DNA metabolic process (GO:0006259) 3.094SMC1A, RAD21, KMT2A, SMC3
aromatic compound biosynthetic process (GO:0019438) 1.74HDAC8, KMT2A, RAD21, TAF6
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.534HDAC8, SMC1A, NIPBL, SMC3
regulation of chromosome organization (GO:0033044) 4.113HDAC8, NIPBL, KMT2A
meiotic cell cycle process (GO:1903046) 4.713SMC1A, RAD21, SMC3
positive regulation of metabolic process (GO:0009893) 1.743KMT2A, RAD21, NIPBL
positive regulation of biosynthetic process (GO:0009891) 2.293KMT2A, RAD21, NIPBL
nuclear division (GO:0000280) 3.853SMC1A, RAD21, SMC3
mitotic S phase (GO:0000084) 6.683SMC1A, RAD21, SMC3
protein modification by small protein conjugation or removal (GO:0070647) 2.953SMC1A, RAD21, SMC3
regulation of cellular component organization (GO:0051128) 2.013HDAC8, NIPBL, KMT2A
response to radiation (GO:0009314) 3.693SMC1A, NIPBL, KMT2A
positive regulation of gene expression (GO:0010628) 2.353NIPBL, RAD21, KMT2A
positive regulation of cellular biosynthetic process (GO:0031328) 2.33KMT2A, RAD21, NIPBL
mitotic sister chromatid cohesion (GO:0007064) 7.333SMC1A, NIPBL, SMC3
mitotic nuclear division (GO:0007067) 4.053SMC1A, RAD21, SMC3
cell division (GO:0051301) 3.683SMC1A, RAD21, SMC3
negative regulation of cell cycle (GO:0045786) 3.673SMC1A, SMC3, TAF6
S phase (GO:0051320) 6.683SMC1A, RAD21, SMC3
regulation of cell cycle process (GO:0010564) 3.53HDAC8, SMC1A, SMC3
regulation of organelle organization (GO:0033043) 2.723HDAC8, KMT2A, NIPBL
regulation of protein metabolic process (GO:0051246) 1.933HDAC8, NIPBL, KMT2A
protein modification by small protein conjugation (GO:0032446) 3.13SMC1A, RAD21, SMC3
regulation of protein modification process (GO:0031399) 2.323HDAC8, NIPBL, KMT2A
positive regulation of biological process (GO:0048518) 1.23KMT2A, RAD21, NIPBL
positive regulation of cellular metabolic process (GO:0031325) 1.813NIPBL, RAD21, KMT2A
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563NIPBL, RAD21, KMT2A
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353KMT2A, RAD21, NIPBL
regulation of DNA metabolic process (GO:0051052) 3.873HDAC8, SMC1A, SMC3
DNA repair (GO:0006281) 3.593SMC1A, RAD21, SMC3
transcription from RNA polymerase II promoter (GO:0006366) 3.383KMT2A, RAD21, TAF6
maintenance of cell number (GO:0098727) 4.823SMC1A, NIPBL, SMC3
regulation of cellular protein metabolic process (GO:0032268) 1.993HDAC8, NIPBL, KMT2A
positive regulation of transcription, DNA-templated (GO:0045893) 2.563KMT2A, RAD21, NIPBL
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293KMT2A, RAD21, NIPBL
protein sumoylation (GO:0016925) 4.983SMC1A, RAD21, SMC3
positive regulation of macromolecule metabolic process (GO:0010604) 1.813KMT2A, RAD21, NIPBL
response to abiotic stimulus (GO:0009628) 2.83SMC1A, NIPBL, KMT2A
single organism reproductive process (GO:0044702) 2.733SMC1A, NIPBL, SMC3
positive regulation of RNA metabolic process (GO:0051254) 2.513NIPBL, RAD21, KMT2A
positive regulation of RNA biosynthetic process (GO:1902680) 2.543NIPBL, RAD21, KMT2A
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393KMT2A, RAD21, NIPBL
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813NIPBL, RAD21, KMT2A
organelle fission (GO:0048285) 3.793SMC1A, RAD21, SMC3
stem cell population maintenance (GO:0019827) 4.833SMC1A, NIPBL, SMC3
positive regulation of cellular process (GO:0048522) 1.33NIPBL, RAD21, KMT2A
regulation of chromatin organization (GO:1902275) 4.692KMT2A, NIPBL
positive regulation of cellular component organization (GO:0051130) 2.682NIPBL, KMT2A
protein localization (GO:0008104) 2.362NIPBL, RAD21
macromolecular complex subunit organization (GO:0043933) 2.142HDAC8, KMT2A
positive regulation of organelle organization (GO:0010638) 3.382KMT2A, NIPBL
regulation of signaling (GO:0023051) 1.722KMT2A, TAF6
regulation of response to stimulus (GO:0048583) 1.542KMT2A, TAF6
negative regulation of gene expression (GO:0010629) 2.482HDAC8, NIPBL
signal transduction (GO:0007165) 1.282SMC1A, SMC3
cellular localization (GO:0051641) 2.322NIPBL, RAD21
regulation of histone modification (GO:0031056) 4.852NIPBL, KMT2A
positive regulation of histone modification (GO:0031058) 5.322KMT2A, NIPBL
cell death (GO:0008219) 3.052KMT2A, RAD21
regulation of DNA-dependent DNA replication (GO:0090329) 5.972SMC1A, SMC3
meiotic nuclear division (GO:0007126) 5.372SMC1A, SMC3
regulation of cell communication (GO:0010646) 1.732KMT2A, TAF6
meiotic cell cycle (GO:0051321) 5.272SMC1A, SMC3
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122HDAC8, NIPBL
chromatin organization (GO:0006325) 3.282HDAC8, KMT2A
positive regulation of protein metabolic process (GO:0051247) 2.432KMT2A, NIPBL
animal organ development (GO:0048513) 2.532KMT2A, NIPBL
positive regulation of cellular protein metabolic process (GO:0032270) 2.492NIPBL, KMT2A
histone modification (GO:0016570) 3.912HDAC8, KMT2A
regulation of molecular function (GO:0065009) 1.782KMT2A, TAF6
macromolecule localization (GO:0033036) 2.342NIPBL, RAD21
(GO:1905269) 5.252NIPBL, KMT2A
regulation of cell proliferation (GO:0042127) 2.412KMT2A, TAF6
negative regulation of cell proliferation (GO:0008285) 3.262KMT2A, TAF6
apoptotic process (GO:0006915) 3.142KMT2A, RAD21
negative regulation of DNA metabolic process (GO:0051053) 4.982SMC1A, SMC3
neurological system process (GO:0050877) 2.642NIPBL, KMT2A
cellular protein localization (GO:0034613) 3.112NIPBL, RAD21
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712HDAC8, NIPBL
negative regulation of RNA biosynthetic process (GO:1902679) 2.72HDAC8, NIPBL
programmed cell death (GO:0012501) 3.12KMT2A, RAD21
mitotic spindle organization (GO:0007052) 6.292SMC1A, SMC3
negative regulation of DNA endoreduplication (GO:0032876) 8.122SMC1A, SMC3
regulation of DNA endoreduplication (GO:0032875) 7.652SMC1A, SMC3
chromosome segregation (GO:0007059) 5.062SMC1A, RAD21
regulation of localization (GO:0032879) 1.942HDAC8, KMT2A
localization (GO:0051179) 1.42NIPBL, RAD21
negative regulation of cell cycle process (GO:0010948) 4.372SMC1A, SMC3
system process (GO:0003008) 2.32KMT2A, NIPBL
regulation of biological quality (GO:0065008) 1.682HDAC8, KMT2A
negative regulation of DNA-dependent DNA replication (GO:2000104) 6.962SMC1A, SMC3
negative regulation of RNA metabolic process (GO:0051253) 2.662HDAC8, NIPBL
anatomical structure development (GO:0048856) 1.582KMT2A, NIPBL
cognition (GO:0050890) 4.22NIPBL, KMT2A
negative regulation of DNA replication (GO:0008156) 6.172SMC1A, SMC3
regulation of DNA replication (GO:0006275) 5.022SMC1A, SMC3
cellular macromolecule localization (GO:0070727) 3.12NIPBL, RAD21
positive regulation of protein modification process (GO:0031401) 2.72KMT2A, NIPBL
negative regulation of transcription, DNA-templated (GO:0045892) 2.752HDAC8, NIPBL
positive regulation of chromosome organization (GO:2001252) 4.762KMT2A, NIPBL
chromatin modification (GO:0016568) 4.062HDAC8, KMT2A
covalent chromatin modification (GO:0016569) 3.892HDAC8, KMT2A

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of chromosome organization (GO:0033044) -4.110.005HDAC8, SMC1A, RAD21, NIPBL, KMT2A
regulation of chromatin organization (GO:1902275) -4.690.003SMC1A, RAD21, NIPBL, KMT2A
regulation of organelle organization (GO:0033043) -2.720.037HDAC8, SMC1A, KMT2A, SMC3, NIPBL, RAD21
regulation of cellular biosynthetic process (GO:0031326) -1.380.008HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
male gamete generation (GO:0048232) NEW3.70.035SMC1A, RAD21, SMC3, TAF6, KMT2A
cell maturation (GO:0048469) NEW4.980.009KMT2A, RAD21, SMC3, TAF6
mitotic cell cycle process (GO:1903047) -3.120.019SMC1A, RAD21, NIPBL, SMC3
cellular component assembly involved in morphogenesis (GO:0010927) NEW4.290.001SMC3, SMC1A, RAD21, KMT2A, TAF6
negative regulation of gene expression (GO:0010629) -2.480.004HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
cell cycle process (GO:0022402) -2.750.001HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of histone modification (GO:0031056) -4.850.002NIPBL, SMC1A, RAD21, KMT2A
mitotic sister chromatid cohesion (GO:0007064) -7.330.0SMC1A, NIPBL, SMC3
regulation of DNA-dependent DNA replication (GO:0090329) -5.970.021SMC1A, SMC3
developmental maturation (GO:0021700) NEW4.70.036KMT2A, RAD21, SMC3, TAF6
cell cycle (GO:0007049) -3.140.03HDAC8, SMC1A, RAD21, NIPBL, SMC3
sister chromatid cohesion (GO:0007062) -5.030.0HDAC8, SMC1A, NIPBL, SMC3
DNA methylation (GO:0006306) NEW5.920.005KMT2A, RAD21, SMC3
DNA alkylation (GO:0006305) NEW5.920.005KMT2A, RAD21, SMC3
DNA modification (GO:0006304) NEW5.360.022KMT2A, RAD21, SMC3
macromolecule methylation (GO:0043414) NEW4.420.013SMC3, SMC1A, KMT2A, TAF6
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) -3.120.01HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6
chromatin organization (GO:0006325) -3.280.001HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
regulation of cellular macromolecule biosynthetic process (GO:2000112) -1.460.005HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of gene expression, epigenetic (GO:0040029) NEW4.580.003SMC1A, RAD21, KMT2A, SMC3
gene expression (GO:0010467) NEW5.80.044HDAC8, SMC1A, RAD21, KMT2A, TAF6
regulation of sister chromatid cohesion (GO:0007063) NEW6.90.037HDAC8, SMC1A
mitotic cell cycle (GO:0000278) NEW5.920.001HDAC8, SMC1A, RAD21, NIPBL, SMC3
DNA repair (GO:0006281) -3.590.004SMC1A, RAD21, SMC3, TAF6, KMT2A
regulation of nucleobase-containing compound metabolic process (GO:0019219) -1.430.016HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
regulation of biosynthetic process (GO:0009889) -1.370.009HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
cellular response to DNA damage stimulus (GO:0006974) -3.170.002SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
spindle organization (GO:0007051) NEW5.330.017SMC1A, SMC3, TAF6
negative regulation of DNA replication (GO:0008156) -6.170.028SMC1A, SMC3
DNA methylation or demethylation (GO:0044728) NEW5.650.01KMT2A, RAD21, SMC3
negative regulation of DNA endoreduplication (GO:0032876) -8.120.002SMC1A, SMC3
regulation of nitrogen compound metabolic process (GO:0051171) -1.360.019HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
genitalia morphogenesis (GO:0035112) NEW7.430.029SMC1A, NIPBL
regulation of DNA endoreduplication (GO:0032875) -7.650.001SMC1A, SMC3
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) -2.60.005HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
organelle assembly (GO:0070925) NEW3.750.005SMC1A, RAD21, SMC3, TAF6, KMT2A
organelle organization (GO:0006996) -2.020.002HDAC8, SMC1A, KMT2A, SMC3, NIPBL, RAD21
stem cell maintenance (GO:0019827) -4.830.002SMC1A, NIPBL, SMC3
spermatogenesis (GO:0007283) NEW3.70.034SMC3, SMC1A, RAD21, KMT2A, TAF6
chromosome organization (GO:0051276) -3.790.0HDAC8, SMC1A, RAD21, NIPBL, SMC3
regulation of cell cycle (GO:0051726) -2.930.045HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
negative regulation of DNA-dependent DNA replication (GO:2000104) -6.960.015SMC1A, SMC3
negative regulation of RNA metabolic process (GO:0051253) -2.660.003HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
mitotic spindle organization (GO:0007052) -6.290.018SMC1A, SMC3
single-organism organelle organization (GO:1902589) NEW2.680.0HDAC8, SMC1A, KMT2A, SMC3, NIPBL, RAD21
regulation of macromolecule biosynthetic process (GO:0010556) -1.430.006HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
negative regulation of RNA biosynthetic process (GO:1902679) -2.70.002HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
DNA metabolic process (GO:0006259) -3.090.036HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
negative regulation of transcription, DNA-templated (GO:0045892) -2.750.002HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) -2.550.005HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
chromatin modification (GO:0016568) -4.060.0HDAC8, SMC1A, KMT2A, SMC3, TAF6, RAD21
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein complex (GO:0043234) 1.517HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
intracellular organelle part (GO:0044446) 0.817HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
macromolecular complex (GO:0032991) 1.357HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
intracellular membrane-bounded organelle (GO:0043231) 0.67HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
nucleus (GO:0005634) 1.077HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
cell part (GO:0044464) 0.117HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
nucleoplasm (GO:0005654) 1.897HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
intracellular organelle (GO:0043229) 0.517HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
nuclear part (GO:0044428) 1.557HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
intracellular part (GO:0044424) 0.287HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
membrane-bounded organelle (GO:0043227) 0.477HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
organelle (GO:0043226) 0.47HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
organelle part (GO:0044422) 0.797HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
cytoplasm (GO:0005737) 1.015HDAC8, SMC1A, TAF6, KMT2A, SMC3
intracellular non-membrane-bounded organelle (GO:0043232) 1.764HDAC8, SMC1A, RAD21, SMC3
cytosol (GO:0005829) 1.684HDAC8, SMC1A, RAD21, SMC3
cytoplasmic part (GO:0044444) 0.824HDAC8, SMC1A, RAD21, SMC3
non-membrane-bounded organelle (GO:0043228) 1.764HDAC8, SMC1A, RAD21, SMC3
chromosomal part (GO:0044427) 3.184SMC1A, RAD21, NIPBL, SMC3
chromosome (GO:0005694) 3.784HDAC8, SMC1A, RAD21, SMC3
meiotic cohesin complex (GO:0030893) 7.863SMC1A, RAD21, SMC3
chromosome, centromeric region (GO:0000775) 4.853SMC1A, RAD21, SMC3
nucleoplasm part (GO:0044451) 3.223HDAC8, KMT2A, TAF6
chromatin (GO:0000785) 3.993NIPBL, RAD21, SMC3
nuclear chromosome (GO:0000228) 5.553HDAC8, SMC1A, RAD21
cohesin complex (GO:0008278) 7.53SMC1A, RAD21, SMC3
chromosomal region (GO:0098687) 4.193SMC1A, RAD21, SMC3
catalytic complex (GO:1902494) 2.93HDAC8, KMT2A, TAF6
cohesin core heterodimer (GO:0008280) 9.112SMC1A, SMC3
transferase complex (GO:1990234) 3.322KMT2A, TAF6
condensed chromosome (GO:0000793) 5.642SMC1A, RAD21
membrane (GO:0016020) 0.682HDAC8, RAD21
condensed nuclear chromosome (GO:0000794) 6.112SMC1A, RAD21
histone methyltransferase complex (GO:0035097) 5.542KMT2A, TAF6
extracellular region part (GO:0044421) 1.572NIPBL, SMC3
nuclear chromosome part (GO:0044454) 3.672RAD21, SMC3
nuclear meiotic cohesin complex (GO:0034991) 8.012RAD21, SMC3
nuclear cohesin complex (GO:0000798) 8.012RAD21, SMC3
MLL1 complex (GO:0071339) 6.472KMT2A, TAF6
methyltransferase complex (GO:0034708) 5.32KMT2A, TAF6
MLL1/2 complex (GO:0044665) 6.472KMT2A, TAF6

NET-GE enrichment

Term New enriched termICP valueGenes
condensed nuclear chromosome (GO:0000794) -6.110.025SMC1A, SMC3
aggresome (GO:0016235) NEW6.250.018SMC1A, SMC3
chromatin (GO:0000785) -3.990.0NIPBL, KMT2A, RAD21, SMC1A, SMC3
nuclear chromosome (GO:0000228) -5.550.001HDAC8, SMC1A, SMC3
focal adhesion (GO:0005925) NEW3.830.001SMC1A, RAD21, SMC3, TAF6, KMT2A
cohesin complex (GO:0008278) -7.50.0SMC1A, RAD21, SMC3
methyltransferase complex (GO:0034708) -5.30.022KMT2A, TAF6
cell-substrate junction (GO:0030055) NEW3.820.001SMC3, SMC1A, RAD21, KMT2A, TAF6
intermediate filament cytoskeleton (GO:0045111) NEW5.790.0SMC1A, RAD21, SMC3, TAF6
cell-substrate adherens junction (GO:0005924) NEW3.830.001SMC3, SMC1A, RAD21, KMT2A, TAF6
nucleolus (GO:0005730) NEW3.060.043HDAC8, SMC1A, RAD21, NIPBL, SMC3
nucleus (GO:0005634) -1.070.016HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
sperm part (GO:0097223) NEW4.830.043SMC1A, RAD21, SMC3
male germ cell nucleus (GO:0001673) NEW6.970.024SMC1A, SMC3
nucleoplasm (GO:0005654) -1.890.0HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
nuclear chromosome part (GO:0044454) -3.670.0SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
nucleoplasm part (GO:0044451) -3.220.001HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6
chromosome (GO:0005694) -3.780.001HDAC8, SMC1A, RAD21, SMC3
MLL1 complex (GO:0071339) -6.470.009KMT2A, TAF6
cohesin core heterodimer (GO:0008280) -9.110.0SMC1A, SMC3
meiotic cohesin complex (GO:0030893) -7.860.0SMC1A, RAD21, SMC3
anchoring junction (GO:0070161) NEW3.610.003SMC3, SMC1A, RAD21, KMT2A, TAF6
adherens junction (GO:0005912) NEW3.660.003SMC3, SMC1A, RAD21, KMT2A, TAF6
nuclear meiotic cohesin complex (GO:0034991) -8.010.0RAD21, SMC3
nuclear cohesin complex (GO:0000798) -8.010.0RAD21, SMC3
chromosome, centromeric region (GO:0000775) -4.850.0SMC1A, RAD21, NIPBL, SMC3
protein complex (GO:0043234) -1.510.001HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
macromolecular complex (GO:0032991) -1.350.004HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
protein-DNA complex (GO:0032993) NEW5.030.001SMC1A, RAD21, NIPBL, SMC3
histone methyltransferase complex (GO:0035097) -5.540.013KMT2A, TAF6
nuclear part (GO:0044428) -1.550.046HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
germ cell nucleus (GO:0043073) NEW6.760.043SMC1A, SMC3
chromosomal part (GO:0044427) -3.180.0HDAC8, SMC1A, KMT2A, SMC3, NIPBL, TAF6, RAD21
MLL1/2 complex (GO:0044665) -6.470.009KMT2A, TAF6