Disease table of ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED OMIM ID: PS610551

Gene-disease associations table

GeneAssociated with ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IRF3OMIM, HUMSAVARHGNC link19q13.331PS610551
TICAM1ClinVar, OMIM, HUMSAVARHGNC link19p13.31PS610551
TRAF3ClinVar, OMIM, HUMSAVARHGNC link14q32.321PS610551
CPT2ClinVar, OMIMHGNC link1p32.34608836, 600649, 255110, PS610551
TLR3ClinVar, OMIM, HUMSAVARHGNC link4q35.12PS610551, 609423
UNC93B1ClinVar, OMIMHGNC link11q13.21PS610551
RANBP2ClinVar, OMIM, HUMSAVARHGNC link2q131PS610551

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
192IRF3, TICAM1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
IRF3YES16IRF5, IFNB1, TLR3, CCL5, TNPO1, IFNA1, IFNL1, IRF7, TANK, ABCC2, CXCL10, PURA, MAVS, SOCS2, CCL2, TLR41TLR3
E2F1NO123WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B2TLR3, IRF3
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
IRF3YES1E2F10
TICAM1YES1SP10
TLR3YES6IRF8, IRF3, RELA, E2F1, NFKB1, STAT11IRF3
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
IRF3TICAM1Yes10TICAM1, TRAF3, TRAF6, PIAS4, TANK, TRAF2, XPO1, MAVS, TBK1, IRF3
IRF3TRAF3Yes11TMEM173, TRAF3IP2, IKBKE, TICAM1, TRAF3, TANK, MAVS, TRAF2, EWSR1, TBK1, IRF3
IRF3TLR3No4TICAM1, TRAF3, TBK1, TRAF6
IRF3RANBP2No2CUL1, IPO5
TICAM1TRAF3Yes16TRAF1, TLR3, MAVS, TBK1, TRAF3, TANK, TRAF5, RIPK1, TRAF2, TLR4, CFLAR, SYK, CBLB, RNF216, TICAM1, IRF3
TICAM1TLR3Yes7TICAM1, TRAF3, TRAF6, RIPK1, SYK, RNF216, TBK1
TRAF3TLR3Yes7RNF216, TICAM1, TRAF3, RIPK1, SYK, MYD88, TBK1
TRAF3UNC93B1No2ABCC1, TLR9
TRAF3RANBP2No2UBE2I, NUP62
UNC93B1RANBP2No1NXF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
IRF3TICAM1Yesbinding6TBK1, MAVS, TLR4, UBC, IRF7, TLR2
IRF3CPT2No-1CREBBP
IRF3RANBP2No-3UBC, PML, HSP90AA1
TICAM1RANBP2No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
IRF3TICAM1Yes2TICAM1, IRF3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Herpes simplex infectionhsa051685.084TICAM1, TRAF3, TLR3, IRF3
Toll-like receptor signaling pathwayhsa046206.04TICAM1, TRAF3, TLR3, IRF3
Hepatitis Chsa051605.684TICAM1, TRAF3, TLR3, IRF3
Influenza Ahsa051645.213TICAM1, TLR3, IRF3
Hepatitis Bhsa051615.523TICAM1, TLR3, IRF3
Pertussishsa051336.462TICAM1, IRF3
NF-kappa B signaling pathwayhsa040646.212TICAM1, TRAF3
RIG-I-like receptor signaling pathwayhsa046226.622TRAF3, IRF3
Viral carcinogenesishsa052035.082TRAF3, IRF3
Epstein-Barr virus infectionhsa051694.972TRAF3, IRF3

NET-GE enrichment

Term New enriched termICP valueGenes
Pertussis (hsa05133) -6.460.016TICAM1, TRAF3, IRF3
Toll-like receptor signaling pathway (hsa04620) -6.00.0TICAM1, TRAF3, TLR3, IRF3
RIG-I-like receptor signaling pathway (hsa04622) -6.620.004TRAF3, TLR3, IRF3
TNF signaling pathway (hsa04668) NEW5.960.034TRAF3, TLR3, IRF3
Herpes simplex infection (hsa05168) -5.080.0TICAM1, TRAF3, TLR3, IRF3
Influenza A (hsa05164) -5.210.011TICAM1, TRAF3, TLR3, IRF3
NF-kappa B signaling pathway (hsa04064) -6.210.0TICAM1, TRAF3, TLR3, IRF3
Hepatitis C (hsa05160) -5.680.0TICAM1, TRAF3, TLR3, IRF3
Hepatitis B (hsa05161) -5.520.007TICAM1, TLR3, IRF3
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.376TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
Toll-Like Receptors CascadesR-HSA-1688985.915TICAM1, UNC93B1, TRAF3, TLR3, IRF3
Innate Immune SystemR-HSA-1682493.175TICAM1, TRAF3, UNC93B1, IRF3, TLR3
DiseaseR-HSA-16436853.335RANBP2, UNC93B1, TRAF3, TICAM1, TLR3
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.474TICAM1, TRAF3, TLR3, IRF3
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.114TICAM1, TRAF3, TLR3, IRF3
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.474TICAM1, TRAF3, TLR3, IRF3
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.474TICAM1, TRAF3, TLR3, IRF3
Diseases associated with the TLR signaling cascadeR-HSA-56023588.344UNC93B1, TRAF3, TICAM1, TLR3
Diseases of Immune SystemR-HSA-52602718.344UNC93B1, TRAF3, TICAM1, TLR3
Activated TLR4 signallingR-HSA-1660546.274TICAM1, TRAF3, TLR3, IRF3
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilonR-HSA-9369648.814TICAM1, TRAF3, TLR3, IRF3
Cytokine Signaling in Immune systemR-HSA-12802153.743TRAF3, RANBP2, IRF3
ZBP1(DAI) mediated induction of type I IFNsR-HSA-16063228.283TICAM1, TLR3, IRF3
TRAF3 deficiency - HSER-HSA-560257111.43TICAM1, TRAF3, TLR3
Cytosolic sensors of pathogen-associated DNA R-HSA-18349496.943TICAM1, TLR3, IRF3
MetabolismR-HSA-14307282.342RANBP2, CPT2
TRAF6 mediated induction of TAK1 complexR-HSA-9370728.982TICAM1, TLR3
Trafficking and processing of endosomal TLRR-HSA-16791319.282UNC93B1, TLR3
TRAF3-dependent IRF activation pathwayR-HSA-9182339.182TRAF3, IRF3
IKK complex recruitment mediated by RIP1R-HSA-9370418.462TICAM1, TLR3
Caspase activation via extrinsic apoptotic signalig pathwayR-HSA-53577698.342TICAM1, TLR3
UNC93B1 deficiency - HSER-HSA-560241511.982UNC93B1, TLR3
Programmed Cell DeathR-HSA-53578015.652TICAM1, TLR3
TICAM1 deficiency - HSER-HSA-560256611.982TICAM1, TLR3
ISG15 antiviral mechanismR-HSA-11694086.832RANBP2, IRF3
Ligand-dependent caspase activationR-HSA-1405349.082TICAM1, TLR3
TRIF-mediated programmed cell deathR-HSA-25625789.662TICAM1, TLR3
RIP-mediated NFkB activation via ZBP1R-HSA-18104768.592TICAM1, TLR3
Negative regulators of RIG-I/MDA5 signalingR-HSA-9364407.982TRAF3, IRF3
Interferon SignalingR-HSA-9135314.952RANBP2, IRF3
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.72TRAF3, IRF3
ApoptosisR-HSA-1095815.682TICAM1, TLR3
Antiviral mechanism by IFN-stimulated genesR-HSA-11694106.832RANBP2, IRF3

NET-GE enrichment

Term New enriched termICP valueGenes
TRIF-mediated TLR3/TLR4 signaling (R-HSA-937061) -6.470.0TICAM1, TRAF3, TLR3, IRF3
IKK complex recruitment mediated by RIP1 (R-HSA-937041) -8.460.0TICAM1, TRAF3, TLR3
Immune System (R-HSA-168256) -2.370.03TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
TICAM1 deficiency - HSE (R-HSA-5602566) -11.980.0TICAM1, TLR3
Ligand-dependent caspase activation (R-HSA-140534) -9.080.007TICAM1, TLR3
Diseases associated with the TLR signaling cascade (R-HSA-5602358) -8.340.0UNC93B1, TRAF3, TICAM1, TLR3
Disease (R-HSA-1643685) -3.330.017RANBP2, UNC93B1, TRAF3, TICAM1, TLR3
TRAF3-dependent IRF activation pathway (R-HSA-918233) -9.180.006TRAF3, IRF3
Toll Like Receptor 3 (TLR3) Cascade (R-HSA-168164) -6.470.0TICAM1, TRAF3, TLR3, IRF3
Toll-Like Receptors Cascades (R-HSA-168898) -5.910.0TICAM1, UNC93B1, TRAF3, TLR3, IRF3
MyD88-independent TLR3/TLR4 cascade (R-HSA-166166) -6.470.0TICAM1, TRAF3, TLR3, IRF3
ZBP1(DAI) mediated induction of type I IFNs (R-HSA-1606322) -8.280.0TICAM1, TRAF3, TLR3, IRF3
UNC93B1 deficiency - HSE (R-HSA-5602415) -11.980.0UNC93B1, TLR3
TRAF3 deficiency - HSE (R-HSA-5602571) -11.40.0TICAM1, TRAF3, TLR3
TRAF6 mediated induction of TAK1 complex (R-HSA-937072) -8.980.0TICAM1, TRAF3, TLR3
Toll Like Receptor 4 (TLR4) Cascade (R-HSA-166016) -6.110.0TICAM1, TRAF3, TLR3, IRF3
Caspase activation via extrinsic apoptotic signalig pathway (R-HSA-5357769) -8.340.019TICAM1, TLR3
Innate Immune System (R-HSA-168249) -3.170.029TICAM1, TRAF3, UNC93B1, IRF3, TLR3
Trafficking and processing of endosomal TLR (R-HSA-1679131) -9.280.005UNC93B1, TLR3
TRIF-mediated programmed cell death (R-HSA-2562578) -9.660.003TICAM1, TLR3
RIP-mediated NFkB activation via ZBP1 (R-HSA-1810476) -8.590.0TICAM1, TRAF3, TLR3
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949) -6.940.0TICAM1, TRAF3, TLR3, IRF3
Diseases of Immune System (R-HSA-5260271) -8.340.0UNC93B1, TRAF3, TICAM1, TLR3
Regulation of innate immune responses to cytosolic DNA (R-HSA-3134975) NEW9.080.012TRAF3, IRF3
Negative regulators of RIG-I/MDA5 signaling (R-HSA-936440) -7.980.031TRAF3, IRF3
Activated TLR4 signalling (R-HSA-166054) -6.270.0TICAM1, TRAF3, TLR3, IRF3
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964) -8.810.0TICAM1, TRAF3, TLR3, IRF3
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185RANBP2, TICAM1, TRAF3, TLR3, IRF3
protein binding (GO:0005515) 0.465TICAM1, TRAF3, RANBP2, IRF3, TLR3
nucleic acid binding (GO:0003676) 1.443RANBP2, TLR3, IRF3
organic cyclic compound binding (GO:0097159) 1.053RANBP2, TLR3, IRF3
enzyme binding (GO:0019899) 2.273TICAM1, TRAF3, RANBP2
catalytic activity (GO:0003824) 1.053TRAF3, RANBP2, CPT2
transferase activity (GO:0016740) 1.953TRAF3, RANBP2, CPT2
signal transducer activity (GO:0004871) 2.283TICAM1, TRAF3, TLR3
heterocyclic compound binding (GO:1901363) 1.063RANBP2, TLR3, IRF3
ubiquitin-like protein transferase activity (GO:0019787) 3.692TRAF3, RANBP2
cation binding (GO:0043169) 1.42TRAF3, RANBP2
transition metal ion binding (GO:0046914) 2.482TRAF3, RANBP2
ion binding (GO:0043167) 1.362TRAF3, RANBP2
protein kinase binding (GO:0019901) 3.442TICAM1, TRAF3
kinase binding (GO:0019900) 3.322TICAM1, TRAF3
zinc ion binding (GO:0008270) 2.662TRAF3, RANBP2
metal ion binding (GO:0046872) 1.412TRAF3, RANBP2
ligase activity (GO:0016874) 3.722TRAF3, RANBP2
identical protein binding (GO:0042802) 2.632TLR3, IRF3
RNA binding (GO:0003723) 2.362RANBP2, TLR3
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.267TLR3, CPT2, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
regulation of response to stress (GO:0080134) 2.536TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
regulation of response to stimulus (GO:0048583) 1.546TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
regulation of cellular process (GO:0050794) 0.56TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
single-organism cellular process (GO:0044763) 0.656TLR3, CPT2, TICAM1, TRAF3, RANBP2, IRF3
biological regulation (GO:0065007) 0.396TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
regulation of biological process (GO:0050789) 0.456TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
single-organism process (GO:0044699) 0.486TLR3, CPT2, TICAM1, TRAF3, RANBP2, IRF3
regulation of primary metabolic process (GO:0080090) 1.085RANBP2, TICAM1, TRAF3, TLR3, IRF3
regulation of metabolic process (GO:0019222) 1.025RANBP2, TICAM1, TRAF3, TLR3, IRF3
positive regulation of response to stimulus (GO:0048584) 2.185TICAM1, UNC93B1, TRAF3, IRF3, TLR3
regulation of cellular metabolic process (GO:0031323) 1.075RANBP2, TICAM1, TRAF3, TLR3, IRF3
positive regulation of defense response (GO:0031349) 3.835TICAM1, UNC93B1, TRAF3, IRF3, TLR3
signal transduction (GO:0007165) 1.285TICAM1, UNC93B1, TRAF3, IRF3, TLR3
regulation of defense response (GO:0031347) 3.115TICAM1, TRAF3, UNC93B1, IRF3, TLR3
immune response-regulating signaling pathway (GO:0002764) 3.725TICAM1, UNC93B1, TRAF3, IRF3, TLR3
interspecies interaction between organisms (GO:0044419) 3.085TICAM1, RANBP2, UNC93B1, TLR3, IRF3
organic substance metabolic process (GO:0071704) 0.635RANBP2, CPT2, TRAF3, TLR3, IRF3
positive regulation of immune system process (GO:0002684) 2.965TICAM1, UNC93B1, TRAF3, IRF3, TLR3
regulation of immune system process (GO:0002682) 2.55TICAM1, UNC93B1, TRAF3, IRF3, TLR3
toll-like receptor signaling pathway (GO:0002224) 5.265TICAM1, TRAF3, UNC93B1, IRF3, TLR3
negative regulation of biological process (GO:0048519) 1.335RANBP2, TICAM1, TRAF3, TLR3, IRF3
pattern recognition receptor signaling pathway (GO:0002221) 5.025TICAM1, UNC93B1, TRAF3, TLR3, IRF3
positive regulation of innate immune response (GO:0045089) 4.225TICAM1, TRAF3, UNC93B1, IRF3, TLR3
regulation of innate immune response (GO:0045088) 3.865TICAM1, TRAF3, UNC93B1, IRF3, TLR3
regulation of macromolecule metabolic process (GO:0060255) 1.085RANBP2, TICAM1, TRAF3, TLR3, IRF3
innate immune response (GO:0045087) 3.555TICAM1, TRAF3, UNC93B1, IRF3, TLR3
regulation of immune response (GO:0050776) 2.985TICAM1, TRAF3, UNC93B1, IRF3, TLR3
regulation of biosynthetic process (GO:0009889) 1.375RANBP2, TICAM1, TRAF3, TLR3, IRF3
defense response (GO:0006952) 2.785TICAM1, TRAF3, UNC93B1, IRF3, TLR3
positive regulation of biological process (GO:0048518) 1.25TICAM1, UNC93B1, TRAF3, IRF3, TLR3
response to stress (GO:0006950) 1.85TICAM1, TRAF3, UNC93B1, IRF3, TLR3
multi-organism cellular process (GO:0044764) 3.145IRF3, UNC93B1, TLR3, TICAM1, RANBP2
metabolic process (GO:0008152) 0.585RANBP2, CPT2, TRAF3, TLR3, IRF3
immune response (GO:0006955) 2.865TICAM1, TRAF3, UNC93B1, IRF3, TLR3
viral process (GO:0016032) 3.155IRF3, UNC93B1, RANBP2, TLR3, TICAM1
multi-organism process (GO:0051704) 2.655TICAM1, RANBP2, UNC93B1, TLR3, IRF3
primary metabolic process (GO:0044238) 0.695RANBP2, CPT2, TRAF3, TLR3, IRF3
immune response-activating signal transduction (GO:0002757) 3.85TICAM1, UNC93B1, TRAF3, IRF3, TLR3
response to stimulus (GO:0050896) 1.225TICAM1, TRAF3, UNC93B1, IRF3, TLR3
innate immune response-activating signal transduction (GO:0002758) 4.455TICAM1, UNC93B1, TRAF3, IRF3, TLR3
positive regulation of immune response (GO:0050778) 3.45TICAM1, UNC93B1, TRAF3, IRF3, TLR3
cellular metabolic process (GO:0044237) 0.695RANBP2, TLR3, TRAF3, CPT2, IRF3
regulation of gene expression (GO:0010468) 1.375RANBP2, TICAM1, TRAF3, TLR3, IRF3
immune system process (GO:0002376) 2.295TICAM1, TRAF3, UNC93B1, IRF3, TLR3
activation of innate immune response (GO:0002218) 4.415TICAM1, TRAF3, UNC93B1, IRF3, TLR3
activation of immune response (GO:0002253) 3.675TICAM1, TRAF3, UNC93B1, IRF3, TLR3
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.155IRF3, UNC93B1, RANBP2, TLR3, TICAM1
regulation of cellular biosynthetic process (GO:0031326) 1.384TICAM1, TRAF3, TLR3, IRF3
regulation of interferon-beta production (GO:0032648) 5.924TICAM1, TRAF3, TLR3, IRF3
cell surface receptor signaling pathway (GO:0007166) 2.094TICAM1, TRAF3, TLR3, IRF3
cell death (GO:0008219) 3.054TICAM1, TRAF3, TLR3, IRF3
response to external biotic stimulus (GO:0043207) 3.134TICAM1, UNC93B1, IRF3, TLR3
regulation of cytokine production (GO:0001817) 3.44TICAM1, TRAF3, TLR3, IRF3
response to virus (GO:0009615) 4.214TICAM1, TLR3, UNC93B1, IRF3
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464TICAM1, TRAF3, TLR3, IRF3
TRIF-dependent toll-like receptor signaling pathway (GO:0035666) 6.434TICAM1, TRAF3, TLR3, IRF3
regulation of molecular function (GO:0065009) 1.784TICAM1, TRAF3, RANBP2, TLR3
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434TICAM1, TRAF3, TLR3, IRF3
immune effector process (GO:0002252) 3.584TICAM1, UNC93B1, IRF3, TLR3
regulation of nucleic acid-templated transcription (GO:1903506) 1.554TICAM1, TRAF3, TLR3, IRF3
programmed cell death (GO:0012501) 3.14TICAM1, TRAF3, TLR3, IRF3
defense response to other organism (GO:0098542) 3.754UNC93B1, TLR3, TICAM1, IRF3
regulation of nitrogen compound metabolic process (GO:0051171) 1.364TICAM1, TRAF3, TLR3, IRF3
regulation of multicellular organismal process (GO:0051239) 1.874TICAM1, TRAF3, TLR3, IRF3
regulation of RNA biosynthetic process (GO:2001141) 1.554TICAM1, TRAF3, TLR3, IRF3
response to other organism (GO:0051707) 3.484TICAM1, UNC93B1, IRF3, TLR3
defense response to virus (GO:0051607) 4.634TICAM1, UNC93B1, IRF3, TLR3
MyD88-independent toll-like receptor signaling pathway (GO:0002756) 6.334TICAM1, TRAF3, TLR3, IRF3
response to biotic stimulus (GO:0009607) 3.094TICAM1, TLR3, UNC93B1, IRF3
cellular macromolecule metabolic process (GO:0044260) 0.934RANBP2, TRAF3, TLR3, IRF3
response to external stimulus (GO:0009605) 2.554TICAM1, TLR3, UNC93B1, IRF3
protein metabolic process (GO:0019538) 1.454RANBP2, TRAF3, TLR3, IRF3
regulation of RNA metabolic process (GO:0051252) 1.524TICAM1, TRAF3, TLR3, IRF3
macromolecule metabolic process (GO:0043170) 0.834RANBP2, TRAF3, TLR3, IRF3
regulation of transcription, DNA-templated (GO:0006355) 1.564TICAM1, TRAF3, TLR3, IRF3
regulation of macromolecule biosynthetic process (GO:0010556) 1.434TICAM1, TRAF3, TLR3, IRF3
regulation of type I interferon production (GO:0032479) 5.034TICAM1, TRAF3, TLR3, IRF3
negative regulation of cellular process (GO:0048523) 1.414RANBP2, TICAM1, TLR3, IRF3
regulation of transport (GO:0051049) 2.243RANBP2, TLR3, IRF3
regulation of signaling (GO:0023051) 1.723TICAM1, TLR3, IRF3
positive regulation of signaling (GO:0023056) 2.413TICAM1, TLR3, IRF3
positive regulation of intracellular signal transduction (GO:1902533) 2.953TICAM1, TLR3, IRF3
intracellular signal transduction (GO:0035556) 2.393TICAM1, TLR3, IRF3
regulation of cell communication (GO:0010646) 1.733TICAM1, TLR3, IRF3
positive regulation of cell communication (GO:0010647) 2.413TICAM1, TLR3, IRF3
response to organic cyclic compound (GO:0014070) 3.073TICAM1, TLR3, IRF3
cellular protein metabolic process (GO:0044267) 1.633TRAF3, RANBP2, TLR3
regulation of intracellular signal transduction (GO:1902531) 2.313TICAM1, TLR3, IRF3
regulation of signal transduction (GO:0009966) 1.843TICAM1, TLR3, IRF3
positive regulation of signal transduction (GO:0009967) 2.53TICAM1, TLR3, IRF3
positive regulation of multicellular organismal process (GO:0051240) 2.493TICAM1, TLR3, IRF3
negative regulation of multicellular organismal process (GO:0051241) 2.843TRAF3, TLR3, IRF3
regulation of protein metabolic process (GO:0051246) 1.933TICAM1, TRAF3, TLR3
localization (GO:0051179) 1.43UNC93B1, RANBP2, CPT2
positive regulation of interferon-beta production (GO:0032728) 6.293TICAM1, TLR3, IRF3
organic substance transport (GO:0071702) 2.153UNC93B1, RANBP2, CPT2
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 4.273TICAM1, TLR3, IRF3
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 4.543TICAM1, TLR3, IRF3
necrotic cell death (GO:0070265) 6.683TICAM1, TLR3, IRF3
apoptotic process (GO:0006915) 3.143TICAM1, TRAF3, IRF3
transport (GO:0006810) 1.513UNC93B1, RANBP2, CPT2
cellular protein modification process (GO:0006464) 1.793TRAF3, RANBP2, TLR3
positive regulation of type I interferon production (GO:0032481) 5.483TICAM1, TLR3, IRF3
protein modification process (GO:0036211) 1.793TRAF3, RANBP2, TLR3
establishment of localization in cell (GO:0051649) 2.473UNC93B1, RANBP2, CPT2
response to chemical (GO:0042221) 1.983TICAM1, TLR3, IRF3
establishment of localization (GO:0051234) 1.483UNC93B1, RANBP2, CPT2
response to organic substance (GO:0010033) 2.23TICAM1, TLR3, IRF3
cellular localization (GO:0051641) 2.323UNC93B1, RANBP2, CPT2
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.833TICAM1, TRAF3, TLR3
intracellular transport (GO:0046907) 2.673UNC93B1, RANBP2, CPT2
response to nitrogen compound (GO:1901698) 3.123TICAM1, TLR3, IRF3
macromolecule modification (GO:0043412) 1.733TRAF3, RANBP2, TLR3
regulation of localization (GO:0032879) 1.943RANBP2, TLR3, IRF3
response to dsRNA (GO:0043331) 5.843TICAM1, TLR3, IRF3
response to exogenous dsRNA (GO:0043330) 5.923TICAM1, TLR3, IRF3
programmed necrotic cell death (GO:0097300) 6.683TICAM1, TLR3, IRF3
positive regulation of cytokine production (GO:0001819) 3.823TICAM1, TLR3, IRF3
positive regulation of cellular process (GO:0048522) 1.33TICAM1, TLR3, IRF3
protein localization (GO:0008104) 2.362UNC93B1, RANBP2
regulation of phosphate metabolic process (GO:0019220) 2.352RANBP2, TLR3
cytokine-mediated signaling pathway (GO:0019221) 3.62TRAF3, IRF3
negative regulation of response to stimulus (GO:0048585) 2.522TICAM1, TLR3
regulation of cytokine biosynthetic process (GO:0042035) 5.152TICAM1, TLR3
organic cyclic compound biosynthetic process (GO:1901362) 1.662RANBP2, IRF3
organic cyclic compound metabolic process (GO:1901360) 1.262RANBP2, IRF3
cellular response to stimulus (GO:0051716) 1.972TLR3, IRF3
negative regulation of macromolecule metabolic process (GO:0010605) 2.012RANBP2, IRF3
positive regulation of macromolecule metabolic process (GO:0010604) 1.812TICAM1, TLR3
negative regulation of signal transduction (GO:0009968) 2.752TICAM1, TLR3
cell activation involved in immune response (GO:0002263) 4.862TICAM1, TLR3
protein modification by small protein conjugation or removal (GO:0070647) 2.952TRAF3, RANBP2
regulation of programmed cell death (GO:0043067) 2.492TRAF3, TLR3
protein modification by small protein conjugation (GO:0032446) 3.12TRAF3, RANBP2
positive regulation of molecular function (GO:0044093) 2.232TICAM1, TLR3
negative regulation of molecular function (GO:0044092) 2.742TRAF3, RANBP2
positive regulation of interferon-alpha production (GO:0032727) 6.92TLR3, IRF3
macromolecule localization (GO:0033036) 2.342UNC93B1, RANBP2
positive regulation of chemokine production (GO:0032722) 5.822TICAM1, TLR3
positive regulation of transport (GO:0051050) 2.92TLR3, IRF3
establishment of protein localization (GO:0045184) 2.532UNC93B1, RANBP2
heterocycle metabolic process (GO:0046483) 1.312RANBP2, IRF3
regulation of phosphorylation (GO:0042325) 2.52RANBP2, TLR3
negative regulation of signaling (GO:0023057) 2.652TICAM1, TLR3
lipopolysaccharide-mediated signaling pathway (GO:0031663) 6.262TICAM1, IRF3
myeloid cell activation involved in immune response (GO:0002275) 6.072TICAM1, TLR3
myeloid leukocyte activation (GO:0002274) 5.152TICAM1, TLR3
aromatic compound biosynthetic process (GO:0019438) 1.72RANBP2, IRF3
regulation of interferon-alpha production (GO:0032647) 6.732TLR3, IRF3
negative regulation of metabolic process (GO:0009892) 1.932RANBP2, IRF3
positive regulation of metabolic process (GO:0009893) 1.742TICAM1, TLR3
positive regulation of biosynthetic process (GO:0009891) 2.292TICAM1, TLR3
regulation of establishment of protein localization (GO:0070201) 3.022TLR3, IRF3
leukocyte activation (GO:0045321) 3.762TICAM1, TLR3
negative regulation of gene expression (GO:0010629) 2.482RANBP2, IRF3
nitrogen compound metabolic process (GO:0006807) 1.132RANBP2, IRF3
positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557) 5.672TICAM1, TLR3
regulation of tumor necrosis factor superfamily cytokine production (GO:1903555) 5.12TICAM1, TLR3
positive regulation of protein transport (GO:0051222) 3.612TLR3, IRF3
regulation of protein transport (GO:0051223) 3.122TLR3, IRF3
regulation of apoptotic process (GO:0042981) 2.52TRAF3, TLR3
organic substance biosynthetic process (GO:1901576) 1.342RANBP2, IRF3
macrophage activation involved in immune response (GO:0002281) 7.332TICAM1, TLR3
cellular response to dsRNA (GO:0071359) 6.962TLR3, IRF3
intracellular protein transport (GO:0006886) 3.22UNC93B1, RANBP2
regulation of kinase activity (GO:0043549) 3.072RANBP2, TLR3
leukocyte activation involved in immune response (GO:0002366) 4.882TICAM1, TLR3
negative regulation of immune system process (GO:0002683) 3.852TICAM1, TLR3
heterocycle biosynthetic process (GO:0018130) 1.72RANBP2, IRF3
positive regulation of tumor necrosis factor production (GO:0032760) 5.72TICAM1, TLR3
regulation of catalytic activity (GO:0050790) 1.972RANBP2, TLR3
cell activation (GO:0001775) 3.472TICAM1, TLR3
negative regulation of type I interferon production (GO:0032480) 6.072TRAF3, IRF3
inflammatory response (GO:0006954) 3.642TICAM1, TLR3
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722RANBP2, IRF3
RNA metabolic process (GO:0016070) 1.592RANBP2, IRF3
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592RANBP2, IRF3
regulation of cellular response to stress (GO:0080135) 3.42RANBP2, TLR3
biosynthetic process (GO:0009058) 1.322RANBP2, IRF3
regulation of transferase activity (GO:0051338) 2.882RANBP2, TLR3
regulation of immune effector process (GO:0002697) 3.712TRAF3, TLR3
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242TLR3, IRF3
response to bacterium (GO:0009617) 4.182TLR3, IRF3
RNA biosynthetic process (GO:0032774) 1.842RANBP2, IRF3
regulation of response to external stimulus (GO:0032101) 3.062TRAF3, TLR3
cellular biosynthetic process (GO:0044249) 1.372RANBP2, IRF3
cellular nitrogen compound metabolic process (GO:0034641) 1.222RANBP2, IRF3
negative regulation of cell communication (GO:0010648) 2.662TICAM1, TLR3
cellular response to chemical stimulus (GO:0070887) 2.572TLR3, IRF3
positive regulation of establishment of protein localization (GO:1904951) 3.492TLR3, IRF3
regulation of protein localization (GO:0032880) 2.882TLR3, IRF3
nucleobase-containing compound metabolic process (GO:0006139) 1.352RANBP2, IRF3
regulation of chemokine production (GO:0032642) 5.542TICAM1, TLR3
positive regulation of protein metabolic process (GO:0051247) 2.432TICAM1, TLR3
regulation of chemokine biosynthetic process (GO:0045073) 7.162TICAM1, TLR3
positive regulation of cellular protein metabolic process (GO:0032270) 2.492TICAM1, TLR3
regulation of protein modification process (GO:0031399) 2.322TICAM1, TLR3
regulation of interleukin-6 production (GO:0032675) 5.082TICAM1, TLR3
necroptotic process (GO:0070266) 6.92TICAM1, TLR3
negative regulation of MyD88-independent toll-like receptor signaling pathway (GO:0034128) 7.782TICAM1, TLR3
cellular response to nitrogen compound (GO:1901699) 3.792TLR3, IRF3
regulation of MyD88-independent toll-like receptor signaling pathway (GO:0034127) 7.652TICAM1, TLR3
cellular aromatic compound metabolic process (GO:0006725) 1.32RANBP2, IRF3
regulation of toll-like receptor signaling pathway (GO:0034121) 5.882TICAM1, TLR3
positive regulation of NF-kappaB transcription factor activity (GO:0051092) 4.852TICAM1, TLR3
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.292TICAM1, TLR3
regulation of cellular protein metabolic process (GO:0032268) 1.992TICAM1, TLR3
regulation of interferon-beta biosynthetic process (GO:0045357) 7.652TICAM1, TLR3
positive regulation of interferon-beta biosynthetic process (GO:0045359) 7.782TICAM1, TLR3
cellular response to organic cyclic compound (GO:0071407) 3.932TLR3, IRF3
I-kappaB kinase/NF-kappaB signaling (GO:0007249) 5.672TICAM1, TLR3
response to molecule of bacterial origin (GO:0002237) 3.992TICAM1, IRF3
negative regulation of cytokine production (GO:0001818) 4.42TRAF3, IRF3
positive regulation of protein modification process (GO:0031401) 2.72TICAM1, TLR3
toll-like receptor 3 signaling pathway (GO:0034138) 7.652UNC93B1, TLR3
positive regulation of cellular biosynthetic process (GO:0031328) 2.32TICAM1, TLR3
macrophage activation (GO:0042116) 6.292TICAM1, TLR3
positive regulation of cellular metabolic process (GO:0031325) 1.812TICAM1, TLR3
negative regulation of cellular metabolic process (GO:0031324) 2.012RANBP2, IRF3
apoptotic signaling pathway (GO:0097190) 4.122TICAM1, TLR3
nucleic acid metabolic process (GO:0090304) 1.462RANBP2, IRF3
regulation of cell death (GO:0010941) 2.432TRAF3, TLR3
response to lipopolysaccharide (GO:0032496) 4.032TICAM1, IRF3
response to lipid (GO:0033993) 3.112TICAM1, IRF3
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392TICAM1, TLR3
cellular response to organic substance (GO:0071310) 2.782TLR3, IRF3
positive regulation of cytokine biosynthetic process (GO:0042108) 5.652TICAM1, TLR3
negative regulation of toll-like receptor signaling pathway (GO:0034122) 6.432TICAM1, TLR3
positive regulation of chemokine biosynthetic process (GO:0045080) 7.432TICAM1, TLR3
regulation of phosphorus metabolic process (GO:0051174) 2.352RANBP2, TLR3
single-organism transport (GO:0044765) 2.182RANBP2, CPT2
macromolecule biosynthetic process (GO:0009059) 1.612RANBP2, IRF3
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292TICAM1, TLR3
single-organism localization (GO:1902578) 2.092RANBP2, CPT2
response to oxygen-containing compound (GO:1901700) 2.572TICAM1, IRF3
regulation of tumor necrosis factor production (GO:0032680) 5.132TICAM1, TLR3
protein transport (GO:0015031) 2.622UNC93B1, RANBP2
single-organism intracellular transport (GO:1902582) 3.592RANBP2, CPT2
single-organism cellular localization (GO:1902580) 3.162RANBP2, CPT2
positive regulation of interleukin-6 production (GO:0032755) 5.512TICAM1, TLR3

NET-GE enrichment

Term New enriched termICP valueGenes
innate immune response (GO:0045087) -3.550.002UNC93B1, TRAF3, TICAM1, IRF3, TLR3
regulation of interferon-alpha production (GO:0032647) -6.730.008TRAF3, TLR3, IRF3
toll-like receptor 3 signaling pathway (GO:0034138) -7.650.0TICAM1, UNC93B1, TRAF3, TLR3, IRF3
macrophage activation (GO:0042116) -6.290.023TICAM1, TLR3
innate immune response-activating signal transduction (GO:0002758) -4.450.0UNC93B1, TRAF3, TICAM1, IRF3, TLR3
regulation of response to biotic stimulus (GO:0002831) NEW4.30.003TICAM1, TRAF3, TLR3, IRF3
regulation of interferon-beta production (GO:0032648) -5.920.0TICAM1, TRAF3, TLR3, IRF3
positive regulation of defense response (GO:0031349) -3.830.0TICAM1, UNC93B1, TRAF3, TLR3, IRF3
leukocyte activation (GO:0045321) -3.760.037TICAM1, UNC93B1, TRAF3, IRF3, TLR3
response to organic cyclic compound (GO:0014070) -3.070.03TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
regulation of cytokine biosynthetic process (GO:0042035) -5.150.002TICAM1, TRAF3, TLR3, IRF3
macrophage activation involved in immune response (GO:0002281) -7.330.005TICAM1, TLR3
negative regulation of cytokine production (GO:0001818) -4.40.024TICAM1, TRAF3, TLR3, IRF3
regulation of defense response (GO:0031347) -3.110.0UNC93B1, TRAF3, TICAM1, IRF3, TLR3
positive regulation of cytokine biosynthetic process (GO:0042108) -5.650.027TICAM1, TRAF3, TLR3
regulation of defense response to virus (GO:0050688) NEW4.530.037TRAF3, TLR3, IRF3
positive regulation of type I interferon production (GO:0032481) -5.480.0TICAM1, TRAF3, TLR3, IRF3
regulation of protein secretion (GO:0050708) NEW3.770.043TICAM1, TRAF3, TLR3, IRF3
immune response-regulating signaling pathway (GO:0002764) -3.720.026UNC93B1, TRAF3, TICAM1, IRF3, TLR3
response to external biotic stimulus (GO:0043207) -3.130.027UNC93B1, TLR3, TICAM1, IRF3
cellular response to dsRNA (GO:0071359) -6.960.008TLR3, IRF3
response to virus (GO:0009615) -4.210.002TICAM1, UNC93B1, TRAF3, TLR3, IRF3
regulation of cytokine secretion (GO:0050707) NEW4.740.007TICAM1, TRAF3, TLR3, IRF3
regulation of chemokine biosynthetic process (GO:0045073) -7.160.005TICAM1, TLR3
positive regulation of interferon-beta biosynthetic process (GO:0045359) -7.780.003TICAM1, TLR3
positive regulation of immune system process (GO:0002684) -2.960.002TICAM1, UNC93B1, TRAF3, IRF3, TLR3
regulation of immune system process (GO:0002682) -2.50.021UNC93B1, TRAF3, TICAM1, IRF3, TLR3
toll-like receptor 4 signaling pathway (GO:0034142) NEW6.840.0TICAM1, TRAF3, TLR3, IRF3
positive regulation of interferon-beta production (GO:0032728) -6.290.016TRAF3, TLR3, IRF3
immune effector process (GO:0002252) -3.580.013UNC93B1, TRAF3, TICAM1, IRF3, TLR3
TRIF-dependent toll-like receptor signaling pathway (GO:0035666) -6.430.0TICAM1, TRAF3, TLR3, IRF3
regulation of protein localization (GO:0032880) -2.880.01TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
pattern recognition receptor signaling pathway (GO:0002221) -5.020.0TICAM1, TRAF3, UNC93B1, IRF3, TLR3
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) -4.270.001TICAM1, UNC93B1, TRAF3, TLR3, IRF3
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) -4.540.0UNC93B1, TRAF3, TICAM1, IRF3, TLR3
positive regulation of tumor necrosis factor production (GO:0032760) -5.70.046TICAM1, TRAF3, TLR3
regulation of cytokine production (GO:0001817) -3.40.009TICAM1, TRAF3, TLR3, IRF3
positive regulation of innate immune response (GO:0045089) -4.220.0UNC93B1, TRAF3, TICAM1, IRF3, TLR3
response to cytokine (GO:0034097) NEW3.840.026TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
response to tumor necrosis factor (GO:0034612) NEW4.930.005TICAM1, TRAF3, TLR3, IRF3
regulation of immune response (GO:0050776) -2.980.004UNC93B1, TRAF3, TICAM1, IRF3, TLR3
positive regulation of chemokine biosynthetic process (GO:0045080) -7.430.012TICAM1, TLR3
regulation of toll-like receptor signaling pathway (GO:0034121) -5.880.005TICAM1, TRAF3, TLR3
toll-like receptor 9 signaling pathway (GO:0034162) NEW7.020.01UNC93B1, TRAF3, TLR3
toll-like receptor signaling pathway (GO:0002224) -5.260.0TICAM1, UNC93B1, TRAF3, IRF3, TLR3
cell activation (GO:0001775) -3.470.008TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
negative regulation of type I interferon production (GO:0032480) -6.070.049TRAF3, IRF3
defense response to other organism (GO:0098542) -3.750.006TICAM1, UNC93B1, TRAF3, TLR3, IRF3
myeloid cell activation involved in immune response (GO:0002275) -6.070.039TICAM1, TLR3
inflammatory response (GO:0006954) -3.640.028TICAM1, TRAF3, UNC93B1, IRF3, TLR3
immune response (GO:0006955) -2.860.012TICAM1, UNC93B1, TRAF3, TLR3, IRF3
leukocyte mediated immunity (GO:0002443) NEW5.310.031TRAF3, TLR3, IRF3
response to other organism (GO:0051707) -3.480.007UNC93B1, TRAF3, TICAM1, IRF3, TLR3
multi-organism process (GO:0051704) -2.650.018IRF3, RANBP2, UNC93B1, TICAM1, TLR3
defense response (GO:0006952) -2.780.02TICAM1, UNC93B1, TRAF3, IRF3, TLR3
MyD88-independent toll-like receptor signaling pathway (GO:0002756) -6.330.0TICAM1, TRAF3, TLR3, IRF3
immune response-activating signal transduction (GO:0002757) -3.80.007TICAM1, UNC93B1, TRAF3, TLR3, IRF3
response to biotic stimulus (GO:0009607) -3.090.033UNC93B1, TLR3, TICAM1, IRF3
defense response to virus (GO:0051607) -4.630.0TICAM1, UNC93B1, TLR3, IRF3
regulation of interferon-beta biosynthetic process (GO:0045357) -7.650.0TICAM1, TLR3, IRF3
lymphocyte mediated immunity (GO:0002449) NEW5.590.013TRAF3, TLR3, IRF3
cellular response to cytokine stimulus (GO:0071345) NEW4.330.014RANBP2, TRAF3, TLR3, IRF3
lipopolysaccharide-mediated signaling pathway (GO:0031663) -6.260.028TICAM1, IRF3
regulation of innate immune response (GO:0045088) -3.860.002TICAM1, TRAF3, UNC93B1, IRF3, TLR3
cellular response to exogenous dsRNA (GO:0071360) NEW7.160.014TLR3, IRF3
I-kappaB kinase/NF-kappaB signaling (GO:0007249) -5.670.002TICAM1, TRAF3, TLR3
positive regulation of immune response (GO:0050778) -3.40.001UNC93B1, TRAF3, TICAM1, IRF3, TLR3
activation of innate immune response (GO:0002218) -4.410.0UNC93B1, TRAF3, TICAM1, IRF3, TLR3
response to dsRNA (GO:0043331) -5.840.0TICAM1, TRAF3, TLR3, IRF3
response to exogenous dsRNA (GO:0043330) -5.920.0TICAM1, TRAF3, TLR3, IRF3
activation of immune response (GO:0002253) -3.670.0UNC93B1, TRAF3, TICAM1, IRF3, TLR3
regulation of type I interferon production (GO:0032479) -5.030.0TICAM1, TRAF3, TLR3, IRF3
regulation of response to stress (GO:0080134) -2.530.004TICAM1, UNC93B1, TRAF3, TLR3, IRF3
positive regulation of interleukin-6 production (GO:0032755) -5.510.005TICAM1, TRAF3, TLR3
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.67TLR3, CPT2, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
cell part (GO:0044464) 0.117TLR3, CPT2, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
cytoplasmic part (GO:0044444) 0.827TLR3, CPT2, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
intracellular organelle (GO:0043229) 0.517TLR3, CPT2, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
intracellular part (GO:0044424) 0.287TLR3, CPT2, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
membrane-bounded organelle (GO:0043227) 0.477TLR3, CPT2, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
organelle (GO:0043226) 0.47TLR3, CPT2, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
intracellular organelle part (GO:0044446) 0.816CPT2, TLR3, UNC93B1, RANBP2, TICAM1, IRF3
organelle part (GO:0044422) 0.796CPT2, TLR3, UNC93B1, RANBP2, TICAM1, IRF3
membrane (GO:0016020) 0.685TICAM1, RANBP2, UNC93B1, CPT2, TLR3
organelle membrane (GO:0031090) 1.975CPT2, UNC93B1, TLR3, TICAM1, RANBP2
vacuole (GO:0005773) 2.924UNC93B1, TRAF3, TICAM1, TLR3
cytosol (GO:0005829) 1.684TICAM1, TRAF3, RANBP2, IRF3
cytoplasm (GO:0005737) 1.013TRAF3, TLR3, IRF3
protein complex (GO:0043234) 1.513TICAM1, TRAF3, RANBP2
macromolecular complex (GO:0032991) 1.353TICAM1, TRAF3, RANBP2
bounding membrane of organelle (GO:0098588) 2.393UNC93B1, TICAM1, TLR3
mitochondrion (GO:0005739) 2.423TRAF3, RANBP2, CPT2
nuclear part (GO:0044428) 1.553RANBP2, CPT2, IRF3
membrane part (GO:0044425) 0.953UNC93B1, TRAF3, TLR3
endosome (GO:0005768) 3.253UNC93B1, TRAF3, TLR3
vacuolar membrane (GO:0005774) 3.452TICAM1, TLR3
endoplasmic reticulum (GO:0005783) 2.562UNC93B1, TLR3
cytoplasmic vesicle (GO:0031410) 2.872UNC93B1, TICAM1
integral component of membrane (GO:0016021) 1.142UNC93B1, TLR3
vesicle (GO:0031982) 1.642UNC93B1, TICAM1
Golgi membrane (GO:0000139) 3.282UNC93B1, TLR3
nucleoplasm (GO:0005654) 1.892CPT2, IRF3
endoplasmic reticulum part (GO:0044432) 2.732UNC93B1, TLR3
Golgi apparatus part (GO:0044431) 3.02UNC93B1, TLR3
vacuolar part (GO:0044437) 3.262TICAM1, TLR3
intracellular vesicle (GO:0097708) 2.862UNC93B1, TICAM1
endosomal part (GO:0044440) 3.732TICAM1, TLR3
whole membrane (GO:0098805) 2.852TICAM1, TLR3
endoplasmic reticulum membrane (GO:0005789) 2.952UNC93B1, TLR3
plasma membrane part (GO:0044459) 1.952TRAF3, TLR3
nucleus (GO:0005634) 1.072RANBP2, IRF3
intrinsic component of membrane (GO:0031224) 1.132UNC93B1, TLR3
endosome membrane (GO:0010008) 3.832TICAM1, TLR3

NET-GE enrichment

Term New enriched termICP valueGenes
receptor complex (GO:0043235) NEW4.010.012UNC93B1, TRAF3, TICAM1, TLR3
lytic vacuole (GO:0000323) NEW3.890.008UNC93B1, TRAF3, TLR3, IRF3
endoplasmic reticulum (GO:0005783) -2.560.004TLR3, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3
vacuole (GO:0005773) -2.920.012UNC93B1, TRAF3, TLR3, IRF3
lysosome (GO:0005764) NEW3.890.008UNC93B1, TRAF3, TLR3, IRF3
endosomal part (GO:0044440) -3.730.047UNC93B1, TRAF3, TICAM1, TLR3
endosome membrane (GO:0010008) -3.830.039UNC93B1, TRAF3, TICAM1, TLR3
organelle membrane (GO:0031090) -1.970.048TLR3, CPT2, UNC93B1, TRAF3, RANBP2, TICAM1, IRF3