Disease table of HEMANGIOMA, CAPILLARY INFANTILE OMIM ID: 602089

Gene-disease associations table

GeneAssociated with HEMANGIOMA, CAPILLARY INFANTILE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
FLT4ClinVar, OMIM, HUMSAVARHGNC link5q35.32602089, PS153100
ANTXR1OMIMHGNC link2p13.32602089, 230740
KDRClinVar, OMIM, HUMSAVARHGNC link4q122602089, PS142623

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
FLT4YES2NFKB1, RELA0
ANTXR1YES1TP530
KDRYES9SP1, NANOG, PTTG1, SP4, HDAC10, ESR1, SP3, E2F1, HEY10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
FLT4KDRNo4GRB2, EPN1, FIGF, SHC1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
FLT4KDRYesactivation, binding76PLCG1, PIK3CG, FGF1, FGF6, FGF10, PLCB4, FGF22, SRC, FGF4, SHC2, EFNA4, PTK2, PGF, VEGFB, PDGFB, FGF14, ANGPT2, CRKL, NRP2, EFNA2, INS, FGF11, FLT1, ITGB1, CRK, FGF18, PIK3R5, ACTA1, CSK, FGF23, SHC4, FIGF, SOS1, VEGFC, SHC1, SHC3, ANGPT1, ANGPT4, PDGFA, IGF1, HGF, PLCB1, EFNA1, FGF20, FGF19, FGF7, PHLPP1, PHLPP2, KITLG, PIK3CB, GRB2, PIK3R3, PXN, CSF1, VEGFA, PLCB3, EFNA5, FGF17, NOTCH1, FGF13, FGF21, FGF2, FGF8, FGF5, ITGA1, PIK3R1, FGF12, BCAR1, FGF9, PIK3CA, EGF, IRS1, PIK3CD, PDGFC, PLCB2, PDGFD
ANTXR1KDRNo-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
FLT4KDRNo1VEGFC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
FLT4KDRyes, complexFLT4 can form a heterodimer with KDR. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Rap1 signaling pathwayhsa040154.972KDR, FLT4
Ras signaling pathwayhsa040144.92KDR, FLT4
Cytokine-cytokine receptor interactionhsa040604.672KDR, FLT4
Focal adhesionhsa045104.922KDR, FLT4
PI3K-Akt signaling pathwayhsa041514.212KDR, FLT4

NET-GE enrichment

Term New enriched termICP valueGenes
Focal adhesion (hsa04510) -4.920.019KDR, FLT4
Rap1 signaling pathway (hsa04015) -4.970.017KDR, FLT4
Ras signaling pathway (hsa04014) -4.90.019KDR, FLT4
Hematopoietic cell lineage (hsa04640) NEW6.180.031KDR, FLT4
Cytokine-cytokine receptor interaction (hsa04060) -4.670.026KDR, FLT4
PI3K-Akt signaling pathway (hsa04151) -4.210.05KDR, FLT4
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signaling by VEGFR-HSA-1941384.662KDR, FLT4
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-1953999.982KDR, FLT4
VEGF ligand-receptor interactionsR-HSA-1943139.982KDR, FLT4
Signal TransductionR-HSA-1625821.782KDR, FLT4

NET-GE enrichment

Term New enriched termICP valueGenes
Elastic fibre formation (R-HSA-1566948) NEW7.490.013KDR, FLT4
VEGF binds to VEGFR leading to receptor dimerization (R-HSA-195399) -9.980.0KDR, FLT4
Uptake and actions of bacterial toxins (R-HSA-5339562) NEW8.280.003KDR, ANTXR1
VEGF ligand-receptor interactions (R-HSA-194313) -9.980.0KDR, FLT4
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
signaling receptor activity (GO:0038023) 2.493ANTXR1, FLT4, KDR
protein binding (GO:0005515) 0.463ANTXR1, FLT4, KDR
molecular transducer activity (GO:0060089) 2.323ANTXR1, FLT4, KDR
transmembrane signaling receptor activity (GO:0004888) 2.573ANTXR1, FLT4, KDR
receptor activity (GO:0004872) 2.323ANTXR1, FLT4, KDR
signal transducer activity (GO:0004871) 2.283ANTXR1, FLT4, KDR
transmembrane receptor activity (GO:0099600) 2.533ANTXR1, FLT4, KDR
binding (GO:0005488) 0.183ANTXR1, FLT4, KDR
purine ribonucleoside triphosphate binding (GO:0035639) 2.222KDR, FLT4
macromolecular complex binding (GO:0044877) 2.612KDR, ANTXR1
purine nucleoside binding (GO:0001883) 2.222KDR, FLT4
heterocyclic compound binding (GO:1901363) 1.062KDR, FLT4
nucleoside phosphate binding (GO:1901265) 1.962KDR, FLT4
nucleoside binding (GO:0001882) 2.212KDR, FLT4
growth factor binding (GO:0019838) 4.892KDR, FLT4
nucleotide binding (GO:0000166) 1.962KDR, FLT4
transmembrane receptor protein tyrosine kinase activity (GO:0004714) 5.552KDR, FLT4
protein tyrosine kinase activity (GO:0004713) 4.542KDR, FLT4
protein kinase activity (GO:0004672) 3.272KDR, FLT4
protein complex binding (GO:0032403) 3.092KDR, ANTXR1
purine nucleotide binding (GO:0017076) 2.192KDR, FLT4
ATP binding (GO:0005524) 2.432KDR, FLT4
kinase activity (GO:0016301) 2.932KDR, FLT4
small molecule binding (GO:0036094) 1.892KDR, FLT4
catalytic activity (GO:0003824) 1.052KDR, FLT4
adenyl nucleotide binding (GO:0030554) 2.42KDR, FLT4
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082KDR, FLT4
organic cyclic compound binding (GO:0097159) 1.052KDR, FLT4
vascular endothelial growth factor-activated receptor activity (GO:0005021) 7.792KDR, FLT4
ribonucleoside binding (GO:0032549) 2.222KDR, FLT4
carbohydrate derivative binding (GO:0097367) 2.032KDR, FLT4
transferase activity (GO:0016740) 1.952KDR, FLT4
adenyl ribonucleotide binding (GO:0032559) 2.412KDR, FLT4
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772KDR, FLT4
purine ribonucleotide binding (GO:0032555) 2.22KDR, FLT4
transmembrane receptor protein kinase activity (GO:0019199) 5.322KDR, FLT4
purine ribonucleoside binding (GO:0032550) 2.222KDR, FLT4
ribonucleotide binding (GO:0032553) 2.192KDR, FLT4

NET-GE enrichment

Term New enriched termICP valueGenes
signaling receptor activity (GO:0038023) -2.490.025ANTXR1, FLT4, KDR
molecular transducer activity (GO:0060089) -2.320.046ANTXR1, FLT4, KDR
vascular endothelial growth factor-activated receptor activity (GO:0005021) -7.790.0KDR, FLT4
receptor tyrosine kinase binding (GO:0030971) NEW5.770.018KDR, FLT4
growth factor binding (GO:0019838) -4.890.007KDR, FLT4
actin binding (GO:0003779) NEW3.740.027ANTXR1, FLT4, KDR
transmembrane signaling receptor activity (GO:0004888) -2.570.019ANTXR1, FLT4, KDR
transmembrane receptor protein tyrosine kinase activity (GO:0004714) -5.550.003KDR, FLT4
protein tyrosine kinase activity (GO:0004713) -4.540.012KDR, FLT4
signal transducer activity (GO:0004871) -2.280.046ANTXR1, FLT4, KDR
transmembrane receptor protein kinase activity (GO:0019199) -5.320.004KDR, FLT4
receptor activity (GO:0004872) -2.320.039ANTXR1, FLT4, KDR
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.363ANTXR1, FLT4, KDR
cellular process (GO:0009987) 0.263ANTXR1, FLT4, KDR
regulation of cellular process (GO:0050794) 0.53ANTXR1, FLT4, KDR
single-organism developmental process (GO:0044767) 1.493ANTXR1, FLT4, KDR
biological regulation (GO:0065007) 0.393ANTXR1, FLT4, KDR
signal transduction (GO:0007165) 1.283ANTXR1, FLT4, KDR
regulation of biological process (GO:0050789) 0.453ANTXR1, FLT4, KDR
single-organism process (GO:0044699) 0.483ANTXR1, FLT4, KDR
regulation of phosphate metabolic process (GO:0019220) 2.352KDR, FLT4
regulation of primary metabolic process (GO:0080090) 1.082KDR, FLT4
regulation of metabolic process (GO:0019222) 1.022KDR, FLT4
positive regulation of response to stimulus (GO:0048584) 2.182KDR, FLT4
regulation of response to stimulus (GO:0048583) 1.542KDR, FLT4
cell surface receptor signaling pathway (GO:0007166) 2.092KDR, FLT4
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242KDR, FLT4
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542KDR, FLT4
cellular component organization or biogenesis (GO:0071840) 1.222KDR, ANTXR1
cellular response to stimulus (GO:0051716) 1.972KDR, FLT4
positive regulation of macromolecule metabolic process (GO:0010604) 1.812KDR, FLT4
regulation of signal transduction (GO:0009966) 1.842KDR, FLT4
cellular developmental process (GO:0048869) 1.822KDR, ANTXR1
peptidyl-tyrosine modification (GO:0018212) 4.472KDR, FLT4
response to growth factor (GO:0070848) 4.142KDR, FLT4
peptidyl-amino acid modification (GO:0018193) 2.982KDR, FLT4
positive regulation of biological process (GO:0048518) 1.22KDR, FLT4
negative regulation of biological process (GO:0048519) 1.332KDR, FLT4
regulation of cell proliferation (GO:0042127) 2.412KDR, FLT4
regulation of phosphorylation (GO:0042325) 2.52KDR, FLT4
regulation of macromolecule metabolic process (GO:0060255) 1.082KDR, FLT4
negative regulation of cell death (GO:0060548) 2.952KDR, FLT4
cellular response to growth factor stimulus (GO:0071363) 4.272KDR, FLT4
response to organic substance (GO:0010033) 2.22KDR, FLT4
positive regulation of epithelial cell migration (GO:0010634) 5.092KDR, FLT4
positive regulation of phosphorylation (GO:0042327) 2.92KDR, FLT4
regulation of epithelial cell migration (GO:0010632) 4.622KDR, FLT4
protein metabolic process (GO:0019538) 1.452KDR, FLT4
cellular response to vascular endothelial growth factor stimulus (GO:0035924) 6.552KDR, FLT4
positive regulation of metabolic process (GO:0009893) 1.742KDR, FLT4
regulation of anatomical structure morphogenesis (GO:0022603) 2.792KDR, FLT4
positive regulation of cell migration (GO:0030335) 3.772KDR, FLT4
regulation of apoptotic process (GO:0042981) 2.52KDR, FLT4
cellular protein metabolic process (GO:0044267) 1.632KDR, FLT4
regulation of cell communication (GO:0010646) 1.732KDR, FLT4
cellular macromolecule metabolic process (GO:0044260) 0.932KDR, FLT4
cellular component organization (GO:0016043) 1.242KDR, ANTXR1
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012KDR, FLT4
regulation of developmental process (GO:0050793) 2.12KDR, FLT4
positive regulation of MAPK cascade (GO:0043410) 3.572KDR, FLT4
macromolecule modification (GO:0043412) 1.732KDR, FLT4
protein modification process (GO:0036211) 1.792KDR, FLT4
metabolic process (GO:0008152) 0.582KDR, FLT4
positive regulation of intracellular signal transduction (GO:1902533) 2.952KDR, FLT4
regulation of intracellular signal transduction (GO:1902531) 2.312KDR, FLT4
response to stimulus (GO:0050896) 1.222KDR, FLT4
positive regulation of protein modification process (GO:0031401) 2.72KDR, FLT4
regulation of cell motility (GO:2000145) 3.162KDR, FLT4
positive regulation of cell motility (GO:2000147) 3.742KDR, FLT4
positive regulation of signal transduction (GO:0009967) 2.52KDR, FLT4
positive regulation of phosphorus metabolic process (GO:0010562) 2.782KDR, FLT4
regulation of multicellular organismal process (GO:0051239) 1.872KDR, FLT4
phosphorylation (GO:0016310) 2.632KDR, FLT4
positive regulation of signaling (GO:0023056) 2.412KDR, FLT4
cellular response to chemical stimulus (GO:0070887) 2.572KDR, FLT4
regulation of signaling (GO:0023051) 1.722KDR, FLT4
positive regulation of cell communication (GO:0010647) 2.412KDR, FLT4
anatomical structure morphogenesis (GO:0009653) 2.532ANTXR1, FLT4
protein autophosphorylation (GO:0046777) 4.462KDR, FLT4
regulation of MAPK cascade (GO:0043408) 3.222KDR, FLT4
vascular endothelial growth factor signaling pathway (GO:0038084) 7.092KDR, FLT4
positive regulation of multicellular organismal process (GO:0051240) 2.492KDR, FLT4
regulation of protein metabolic process (GO:0051246) 1.932KDR, FLT4
positive regulation of protein metabolic process (GO:0051247) 2.432KDR, FLT4
positive regulation of cellular protein metabolic process (GO:0032270) 2.492KDR, FLT4
regulation of protein modification process (GO:0031399) 2.322KDR, FLT4
positive regulation of cell proliferation (GO:0008284) 3.012KDR, FLT4
primary metabolic process (GO:0044238) 0.692KDR, FLT4
regulation of locomotion (GO:0040012) 3.122KDR, FLT4
vascular endothelial growth factor receptor signaling pathway (GO:0048010) 5.442KDR, FLT4
regulation of localization (GO:0032879) 1.942KDR, FLT4
regulation of cellular protein metabolic process (GO:0032268) 1.992KDR, FLT4
regulation of epithelial cell proliferation (GO:0050678) 4.062KDR, FLT4
positive regulation of epithelial cell proliferation (GO:0050679) 4.672KDR, FLT4
macromolecule metabolic process (GO:0043170) 0.832KDR, FLT4
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562KDR, FLT4
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232KDR, FLT4
positive regulation of cellular metabolic process (GO:0031325) 1.812KDR, FLT4
regulation of cellular metabolic process (GO:0031323) 1.072KDR, FLT4
peptidyl-tyrosine phosphorylation (GO:0018108) 4.482KDR, FLT4
angiogenesis (GO:0001525) 4.152KDR, FLT4
regulation of cell death (GO:0010941) 2.432KDR, FLT4
regulation of programmed cell death (GO:0043067) 2.492KDR, FLT4
organic substance metabolic process (GO:0071704) 0.632KDR, FLT4
cellular response to organic substance (GO:0071310) 2.782KDR, FLT4
negative regulation of apoptotic process (GO:0043066) 3.042KDR, FLT4
negative regulation of programmed cell death (GO:0043069) 3.022KDR, FLT4
protein phosphorylation (GO:0006468) 2.892KDR, FLT4
regulation of cell migration (GO:0030334) 3.232KDR, FLT4
positive regulation of phosphate metabolic process (GO:0045937) 2.782KDR, FLT4
cellular protein modification process (GO:0006464) 1.792KDR, FLT4
regulation of phosphorus metabolic process (GO:0051174) 2.352KDR, FLT4
single-organism cellular process (GO:0044763) 0.652KDR, ANTXR1
response to chemical (GO:0042221) 1.982KDR, FLT4
positive regulation of cellular component movement (GO:0051272) 3.712KDR, FLT4
regulation of cellular component movement (GO:0051270) 3.082KDR, FLT4
positive regulation of endothelial cell migration (GO:0010595) 5.522KDR, FLT4
regulation of endothelial cell migration (GO:0010594) 4.992KDR, FLT4
positive regulation of locomotion (GO:0040017) 3.712KDR, FLT4
regulation of endothelial cell proliferation (GO:0001936) 5.142KDR, FLT4
anatomical structure development (GO:0048856) 1.582KDR, FLT4
cellular metabolic process (GO:0044237) 0.692KDR, FLT4
positive regulation of endothelial cell proliferation (GO:0001938) 5.512KDR, FLT4
phosphate-containing compound metabolic process (GO:0006796) 2.162KDR, FLT4
phosphorus metabolic process (GO:0006793) 2.152KDR, FLT4
regulation of protein phosphorylation (GO:0001932) 2.572KDR, FLT4
positive regulation of protein phosphorylation (GO:0001934) 2.952KDR, FLT4
negative regulation of cellular process (GO:0048523) 1.412KDR, FLT4
positive regulation of cellular process (GO:0048522) 1.32KDR, FLT4

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of epithelial cell migration (GO:0010634) -5.090.014KDR, FLT4
vascular endothelial growth factor signaling pathway (GO:0038084) -7.090.003KDR, FLT4
cell-substrate adhesion (GO:0031589) NEW4.750.01ANTXR1, FLT4, KDR
cell morphogenesis involved in differentiation (GO:0000904) NEW4.670.016ANTXR1, FLT4, KDR
positive regulation of endothelial cell migration (GO:0010595) -5.520.007KDR, FLT4
positive regulation of epithelial cell proliferation (GO:0050679) -4.670.047KDR, FLT4
regulation of epithelial cell migration (GO:0010632) -4.620.037KDR, FLT4
substrate adhesion-dependent cell spreading (GO:0034446) NEW6.090.049KDR, ANTXR1
regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947) NEW6.430.028KDR, FLT4
lymph vessel development (GO:0001945) NEW7.330.0KDR, FLT4
regulation of endothelial cell migration (GO:0010594) -4.990.019KDR, FLT4
positive regulation of endothelial cell proliferation (GO:0001938) -5.510.009KDR, FLT4
regulation of endothelial cell proliferation (GO:0001936) -5.140.017KDR, FLT4
vascular endothelial growth factor receptor signaling pathway (GO:0048010) -5.440.016KDR, FLT4
positive regulation of ERK1 and ERK2 cascade (GO:0070374) -4.560.03KDR, FLT4
cellular response to vascular endothelial growth factor stimulus (GO:0035924) -6.550.002KDR, FLT4
cell morphogenesis (GO:0000902) NEW4.350.046ANTXR1, FLT4, KDR
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane-bounded organelle (GO:0043227) 0.473ANTXR1, FLT4, KDR
integral component of membrane (GO:0016021) 1.143ANTXR1, FLT4, KDR
membrane (GO:0016020) 0.683ANTXR1, FLT4, KDR
cell part (GO:0044464) 0.113ANTXR1, FLT4, KDR
plasma membrane (GO:0005886) 1.393ANTXR1, FLT4, KDR
intracellular part (GO:0044424) 0.283ANTXR1, FLT4, KDR
membrane part (GO:0044425) 0.953ANTXR1, FLT4, KDR
plasma membrane part (GO:0044459) 1.953ANTXR1, FLT4, KDR
organelle (GO:0043226) 0.43ANTXR1, FLT4, KDR
intrinsic component of membrane (GO:0031224) 1.133ANTXR1, FLT4, KDR
cytoplasm (GO:0005737) 1.012KDR, FLT4
vesicle (GO:0031982) 1.642KDR, ANTXR1
nucleus (GO:0005634) 1.072KDR, FLT4
cytoplasmic part (GO:0044444) 0.822KDR, ANTXR1
membrane-bounded vesicle (GO:0031988) 1.712KDR, ANTXR1
intracellular organelle (GO:0043229) 0.512KDR, FLT4
extracellular region (GO:0005576) 2.182KDR, FLT4
integral component of plasma membrane (GO:0005887) 2.572KDR, FLT4
intrinsic component of plasma membrane (GO:0031226) 2.532KDR, FLT4
intracellular membrane-bounded organelle (GO:0043231) 0.62KDR, FLT4

NET-GE enrichment

Term New enriched termICP valueGenes
endomembrane system (GO:0012505) NEW4.840.019KDR, FLT4