Gene | Associated with HEMANGIOMA, CAPILLARY INFANTILE in | Link to HGNC | Cytogenetic band | Number of associated diseases | Associated diseases |
---|---|---|---|---|---|
FLT4 | ClinVar, OMIM, HUMSAVAR | HGNC link | 5q35.3 | 2 | 602089, PS153100 |
ANTXR1 | OMIM | HGNC link | 2p13.3 | 2 | 602089, 230740 |
KDR | ClinVar, OMIM, HUMSAVAR | HGNC link | 4q12 | 2 | 602089, PS142623 |
Download the disease annotation in CSV format
regulated gene | associated to this disease | # TFs | TFs | # TFs associated with this disease | TFs associated with this disease |
---|---|---|---|---|---|
FLT4 | YES | 2 | NFKB1, RELA | 0 | |
ANTXR1 | YES | 1 | TP53 | 0 | |
KDR | YES | 9 | SP1, NANOG, PTTG1, SP4, HDAC10, ESR1, SP3, E2F1, HEY1 | 0 |
Gene1 | Gene2 | Direct Interaction | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|
FLT4 | KDR | No | 4 | GRB2, EPN1, FIGF, SHC1 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct Interaction | Interaction mode | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|---|
FLT4 | KDR | Yes | activation, binding | 76 | PLCG1, PIK3CG, FGF1, FGF6, FGF10, PLCB4, FGF22, SRC, FGF4, SHC2, EFNA4, PTK2, PGF, VEGFB, PDGFB, FGF14, ANGPT2, CRKL, NRP2, EFNA2, INS, FGF11, FLT1, ITGB1, CRK, FGF18, PIK3R5, ACTA1, CSK, FGF23, SHC4, FIGF, SOS1, VEGFC, SHC1, SHC3, ANGPT1, ANGPT4, PDGFA, IGF1, HGF, PLCB1, EFNA1, FGF20, FGF19, FGF7, PHLPP1, PHLPP2, KITLG, PIK3CB, GRB2, PIK3R3, PXN, CSF1, VEGFA, PLCB3, EFNA5, FGF17, NOTCH1, FGF13, FGF21, FGF2, FGF8, FGF5, ITGA1, PIK3R1, FGF12, BCAR1, FGF9, PIK3CA, EGF, IRS1, PIK3CD, PDGFC, PLCB2, PDGFD |
ANTXR1 | KDR | No | - | 1 | UBC |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Interaction | Number of common interactors | Common genes in interaction |
---|---|---|---|---|
FLT4 | KDR | No | 1 | VEGFC |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct interaction | More information |
---|---|---|---|
FLT4 | KDR | yes, complex | FLT4 can form a heterodimer with KDR. [UniProt] |
KEGG term | KEGG term ID | IC | Number of genes with the same term | Genes |
---|---|---|---|---|
Rap1 signaling pathway | hsa04015 | 4.97 | 2 | KDR, FLT4 |
Ras signaling pathway | hsa04014 | 4.9 | 2 | KDR, FLT4 |
Cytokine-cytokine receptor interaction | hsa04060 | 4.67 | 2 | KDR, FLT4 |
Focal adhesion | hsa04510 | 4.92 | 2 | KDR, FLT4 |
PI3K-Akt signaling pathway | hsa04151 | 4.21 | 2 | KDR, FLT4 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
Focal adhesion (hsa04510) | - | 4.92 | 0.019 | KDR, FLT4 |
Rap1 signaling pathway (hsa04015) | - | 4.97 | 0.017 | KDR, FLT4 |
Ras signaling pathway (hsa04014) | - | 4.9 | 0.019 | KDR, FLT4 |
Hematopoietic cell lineage (hsa04640) | NEW | 6.18 | 0.031 | KDR, FLT4 |
Cytokine-cytokine receptor interaction (hsa04060) | - | 4.67 | 0.026 | KDR, FLT4 |
PI3K-Akt signaling pathway (hsa04151) | - | 4.21 | 0.05 | KDR, FLT4 |
REACTOME term | REACTOME term ID | IC | Number of genes with the same term | Genes |
---|---|---|---|---|
Signaling by VEGF | R-HSA-194138 | 4.66 | 2 | KDR, FLT4 |
VEGF binds to VEGFR leading to receptor dimerization | R-HSA-195399 | 9.98 | 2 | KDR, FLT4 |
VEGF ligand-receptor interactions | R-HSA-194313 | 9.98 | 2 | KDR, FLT4 |
Signal Transduction | R-HSA-162582 | 1.78 | 2 | KDR, FLT4 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
Elastic fibre formation (R-HSA-1566948) | NEW | 7.49 | 0.013 | KDR, FLT4 |
VEGF binds to VEGFR leading to receptor dimerization (R-HSA-195399) | - | 9.98 | 0.0 | KDR, FLT4 |
Uptake and actions of bacterial toxins (R-HSA-5339562) | NEW | 8.28 | 0.003 | KDR, ANTXR1 |
VEGF ligand-receptor interactions (R-HSA-194313) | - | 9.98 | 0.0 | KDR, FLT4 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
signaling receptor activity (GO:0038023) | - | 2.49 | 0.025 | ANTXR1, FLT4, KDR |
molecular transducer activity (GO:0060089) | - | 2.32 | 0.046 | ANTXR1, FLT4, KDR |
vascular endothelial growth factor-activated receptor activity (GO:0005021) | - | 7.79 | 0.0 | KDR, FLT4 |
receptor tyrosine kinase binding (GO:0030971) | NEW | 5.77 | 0.018 | KDR, FLT4 |
growth factor binding (GO:0019838) | - | 4.89 | 0.007 | KDR, FLT4 |
actin binding (GO:0003779) | NEW | 3.74 | 0.027 | ANTXR1, FLT4, KDR |
transmembrane signaling receptor activity (GO:0004888) | - | 2.57 | 0.019 | ANTXR1, FLT4, KDR |
transmembrane receptor protein tyrosine kinase activity (GO:0004714) | - | 5.55 | 0.003 | KDR, FLT4 |
protein tyrosine kinase activity (GO:0004713) | - | 4.54 | 0.012 | KDR, FLT4 |
signal transducer activity (GO:0004871) | - | 2.28 | 0.046 | ANTXR1, FLT4, KDR |
transmembrane receptor protein kinase activity (GO:0019199) | - | 5.32 | 0.004 | KDR, FLT4 |
receptor activity (GO:0004872) | - | 2.32 | 0.039 | ANTXR1, FLT4, KDR |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
endomembrane system (GO:0012505) | NEW | 4.84 | 0.019 | KDR, FLT4 |