Gene table of MAP3K8 : mitogen-activated protein kinase kinase kinase 8

Gene-disease associations table

Disease ID	Disease name	Source of annotation with MAP3K8	OMIM link	Number of associated genes	genes
211980	LUNG CANCER	OMIM	link to OMIM	17	RASSF1, PARK2, IRF1, CASP8, ERBB2, PPP2R1B, FASLG, MAP3K8, PIK3CA, BRAF, KRAS, DLEC1, SLC22A18, ERCC6, CYP2A6, MXRA5, EGFR

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
T cell receptor signaling pathway	hsa04660	6.01
TNF signaling pathway	hsa04668	5.96
Toll-like receptor signaling pathway	hsa04620	6.0
MAPK signaling pathway	hsa04010	4.63

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
TRIF-mediated TLR3/TLR4 signaling	R-HSA-937061	6.47
Signaling by Interleukins	R-HSA-449147	4.71
Toll Like Receptor 2 (TLR2) Cascade	R-HSA-181438	6.51
Immune System	R-HSA-168256	2.37
Toll Like Receptor 5 (TLR5) Cascade	R-HSA-168176	6.73
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Adaptive Immune System	R-HSA-1280218	3.19
Toll Like Receptor 10 (TLR10) Cascade	R-HSA-168142	6.73
Toll Like Receptor 3 (TLR3) Cascade	R-HSA-168164	6.47
Toll-Like Receptors Cascades	R-HSA-168898	5.91
CD28 co-stimulation	R-HSA-389356	7.98
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.59
MyD88-independent TLR3/TLR4 cascade	R-HSA-166166	6.47
Costimulation by the CD28 family	R-HSA-388841	6.56
Interleukin-1 signaling	R-HSA-446652	7.52
Toll Like Receptor TLR6:TLR2 Cascade	R-HSA-168188	6.56
Toll Like Receptor 4 (TLR4) Cascade	R-HSA-166016	6.11
Toll Like Receptor 7/8 (TLR7/8) Cascade	R-HSA-168181	6.68
Innate Immune System	R-HSA-168249	3.17
Toll Like Receptor TLR1:TLR2 Cascade	R-HSA-168179	6.51
MAP kinase activation in TLR cascade	R-HSA-450294	7.28
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	R-HSA-975138	6.72
MyD88 cascade initiated on plasma membrane	R-HSA-975871	6.73
MyD88 dependent cascade initiated on endosome	R-HSA-975155	6.68
MyD88:Mal cascade initiated on plasma membrane	R-HSA-166058	6.56
Activated TLR4 signalling	R-HSA-166054	6.27
Toll Like Receptor 9 (TLR9) Cascade	R-HSA-168138	6.62

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
ion binding	GO:0043167	1.36
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
receptor signaling protein activity	GO:0005057	4.76
magnesium ion binding	GO:0000287	4.41
ribonucleoside binding	GO:0032549	2.22
nucleotide binding	GO:0000166	1.96
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
purine nucleoside binding	GO:0001883	2.22
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
adenyl nucleotide binding	GO:0030554	2.4
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
organic cyclic compound binding	GO:0097159	1.05
carbohydrate derivative binding	GO:0097367	2.03
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
receptor signaling protein serine/threonine kinase activity	GO:0004702	5.23
purine ribonucleotide binding	GO:0032555	2.2
MAP kinase kinase kinase activity	GO:0004709	6.6
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19