Gene table of IRF1 : interferon regulatory factor 1

Gene-disease associations table

Disease IDDisease nameSource of annotation with IRF1OMIM linkNumber of associated genesgenes
613659GASTRIC CANCEROMIM, HUMSAVAR link to OMIM 9KLF6, ERBB2, PIK3CA, APC, CASP10, IRF1, FGFR2, MUTYH, KRAS
211980LUNG CANCEROMIM link to OMIM 17RASSF1, PARK2, IRF1, CASP8, ERBB2, PPP2R1B, FASLG, MAP3K8, PIK3CA, BRAF, KRAS, DLEC1, SLC22A18, ERCC6, CYP2A6, MXRA5, EGFR

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Annotation of the gene IRF1

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Pertussishsa051336.46
Hepatitis Chsa051605.68
Prolactin signaling pathwayhsa049176.6
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
TRAF6 mediated IRF7 activationR-HSA-9335417.98
Innate Immune SystemR-HSA-1682493.17
Immune SystemR-HSA-1682562.37
Cytokine Signaling in Immune systemR-HSA-12802153.74
Interferon gamma signalingR-HSA-8773005.67
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.7
Interferon alpha/beta signalingR-HSA-9097336.04
Interferon SignalingR-HSA-9135314.95
Factors involved in megakaryocyte development and platelet productionR-HSA-9832315.88
HemostasisR-HSA-1095823.98
Associated GO terms for Molecular function
GO termGO IDGO IC
RNA polymerase II regulatory region DNA bindingGO:00010123.36
core promoter proximal region DNA bindingGO:00011593.82
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00010774.31
nucleic acid binding transcription factor activityGO:00010712.65
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
heterocyclic compound bindingGO:19013631.06
sequence-specific DNA bindingGO:00435652.79
sequence-specific double-stranded DNA bindingGO:19908373.2
core promoter proximal region sequence-specific DNA bindingGO:00009873.83
double-stranded DNA bindingGO:00036903.09
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific bindingGO:00009823.94
RNA polymerase II transcription factor activity, sequence-specific DNA bindingGO:00009813.29
regulatory region nucleic acid bindingGO:00010673.03
transcription regulatory region DNA bindingGO:00442123.03
transcription factor activity, sequence-specific DNA bindingGO:00037002.65
organic cyclic compound bindingGO:00971591.05
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012283.98
transcription regulatory region sequence-specific DNA bindingGO:00009763.24
RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009773.37
protein bindingGO:00055150.46
regulatory region DNA bindingGO:00009753.03
RNA polymerase II core promoter proximal region sequence-specific DNA bindingGO:00009783.88
bindingGO:00054880.18