Gene table of TCF4 : transcription factor 4

Gene-disease associations table

Disease ID	Disease name	Source of annotation with TCF4	OMIM link	Number of associated genes	genes
610954	PITT-HOPKINS SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	TCF4
PS136800	CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL	ClinVar, OMIM	link to OMIM	5	SLC4A11, AGBL1, ZEB1, COL8A2, TCF4

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Annotation of the gene TCF4

Associated genes in ENSEMBL

ENSG00000196628

Associated proteins - SwissProt Accession ID

P15884

Associated PDB IDs

2kwf

Cytogenetic Band

18q21.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Myogenesis	R-HSA-525793	8.12
Developmental Biology	R-HSA-1266738	3.48
CDO in myogenesis	R-HSA-375170	8.12

Associated GO terms for Molecular function

GO term	GO ID	GO IC
protein C-terminus binding	GO:0008022	4.5
RNA polymerase II regulatory region DNA binding	GO:0001012	3.36
core promoter proximal region DNA binding	GO:0001159	3.82
transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting	GO:0001011	9.74
transcription factor activity, RNA polymerase II transcription factor binding	GO:0001076	4.84
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0001077	4.31
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
bHLH transcription factor binding	GO:0043425	6.41
E-box binding	GO:0070888	6.21
heterocyclic compound binding	GO:1901363	1.06
sequence-specific DNA binding	GO:0043565	2.79
sequence-specific double-stranded DNA binding	GO:1990837	3.2
TFIIB-class transcription factor binding	GO:0001093	9.74
RNA polymerase II basal transcription factor binding	GO:0001091	7.79
transcription corepressor activity	GO:0003714	4.33
transcription cofactor activity	GO:0003712	3.44
basal transcription machinery binding	GO:0001098	6.44
basal RNA polymerase II transcription machinery binding	GO:0001099	6.44
identical protein binding	GO:0042802	2.63
transcription factor activity, transcription factor binding	GO:0000989	3.36
transcription factor activity, protein binding	GO:0000988	3.35
core promoter proximal region sequence-specific DNA binding	GO:0000987	3.83
double-stranded DNA binding	GO:0003690	3.09
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0000982	3.94
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
protein homodimerization activity	GO:0042803	3.16
transcription factor binding	GO:0008134	3.46
regulatory region nucleic acid binding	GO:0001067	3.03
RNA polymerase II core promoter proximal region sequence-specific DNA binding	GO:0000978	3.88
protein self-association	GO:0043621	5.93
RNA polymerase II transcription factor binding	GO:0001085	5.08
transcription regulatory region DNA binding	GO:0044212	3.03
transcription factor activity, TFIIB-class binding	GO:0001087	9.74
protein heterodimerization activity	GO:0046982	3.64
transcription factor activity, RNA polymerase II basal transcription factor binding	GO:0001083	9.05
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001228	3.98
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977	3.37
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
protein dimerization activity	GO:0046983	2.72
chromatin binding	GO:0003682	3.64
nucleic acid binding transcription factor activity	GO:0001071	2.65