Gene table of ABCB1 : ATP binding cassette subfamily B member 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with ABCB1	OMIM link	Number of associated genes	genes
PS266600	INFLAMMATORY BOWEL DISEASE	OMIM	link to OMIM	10	ATG16L1, IL10RB, IRGM, IL10RA, NOD2, IRF5, IL23R, ABCB1, SLC22A5, IL6
120080	COLCHICINE RESISTANCE	OMIM	link to OMIM	1	ABCB1

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Annotation of the gene ABCB1

Associated genes in ENSEMBL

ENSG00000085563

Associated proteins - SwissProt Accession ID

P08183

Associated PDB IDs

Cytogenetic Band

7q21.12

Tandem repeats annotation

The gene is in the tandem Group 340, together with the genes:

ABCB4

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
ABC transporters	hsa02010	7.28
MicroRNAs in cancer	hsa05206	5.38
Bile secretion	hsa04976	6.56

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
ABC-family proteins mediated transport	R-HSA-382556	7.59
Abacavir transport and metabolism	R-HSA-2161522	9.66
Metabolism	R-HSA-1430728	2.34
Transmembrane transport of small molecules	R-HSA-382551	3.79
Abacavir transmembrane transport	R-HSA-2161517	10.66

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
binding	GO:0005488	0.18
ATPase activity	GO:0016887	3.65
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
ATPase activity, coupled to transmembrane movement of substances	GO:0042626	5.06
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	GO:0016820	5.03
ATPase activity, coupled	GO:0042623	3.97
drug transmembrane transporter activity	GO:0015238	6.85
primary active transmembrane transporter activity	GO:0015399	4.98
nucleoside phosphate binding	GO:1901265	1.96
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
active transmembrane transporter activity	GO:0022804	3.85
hydrolase activity	GO:0016787	1.9
protein binding	GO:0005515	0.46
transporter activity	GO:0005215	2.57
nucleoside-triphosphatase activity	GO:0017111	3.09
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
	GO:0008559	8.13
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
ATPase activity, coupled to movement of substances	GO:0043492	4.93
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
P-P-bond-hydrolysis-driven transmembrane transporter activity	GO:0015405	4.98
pyrophosphatase activity	GO:0016462	3.04
transmembrane transporter activity	GO:0022857	2.82
adenyl ribonucleotide binding	GO:0032559	2.41
ATP binding	GO:0005524	2.43
xenobiotic transporter activity	GO:0042910	7.95
drug transporter activity	GO:0090484	6.69
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19