Disease table of PHEOCHROMOCYTOMA OMIM ID: 171300

Gene-disease associations table

GeneAssociated with PHEOCHROMOCYTOMA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TMEM127OMIM, HUMSAVARHGNC link2q11.21171300
KIF1BOMIMHGNC link1p36.223PS118220, 256700, 171300
MAXOMIMHGNC link14q23.31171300
RETOMIM, HUMSAVARHGNC link10q11.216171300, 155240, PS142623, 209880, 191830, PS131100
VHLOMIM, HUMSAVARHGNC link3p25.34193300, 144700, PS133100, 171300
GDNFOMIMHGNC link5p13.23171300, PS142623, 209880
SDHBOMIM, HUMSAVARHGNC link1p36.136171300, 604287, 606764, 606864, PS168000, PS158350
SDHDOMIM, HUMSAVARHGNC link11q23.16252011, PS168000, 606864, 114900, 171300, PS158350

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
1p362SDHB, KIF1B
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
1p32SDHB, KIF1B
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1p2SDHB, KIF1B
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
12SDHB, KIF1B
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
MAXYES4HTR1A, ODC1, FASLG, BRD70
VHLYES18CA9, STRA13, TCF4, TFRC, ANGPT2, CXCR4, CCND1, DAB2, KLF10, CDKN1C, CA12, TP53, NMU, HIF1A, SPARC, VEGFA, IGF1R, CDKN1B0
HIF1ANO80RORA, SERPINE1, MICA, MET, WASF3, PLAU, AR, TWIST1, FAM162A, MMP2, SLC2A1, PFKFB4, EDN1, PGK1, LOX, HBEGF, FGF2, SETD2, XPC, ACE, MDK, ACE2, ERCC2, GCK, TLR2, ALOX5AP, LDHA, CXCR4, SOCS1, PPP1R3C, EDNRB, EGLN1, ALDOA, SLC29A1, AGTR1, PFKFB3, LEP, PPARA, ENO1, VHL, TWIST2, E2F3, PTGES, GAPDH, BID, MIF, CA9, CDH1, TIMP2, VIM, ALAS2, ITGB2, NT5E, CTGF, TLR6, CCR7, VEGFB, APEX1, MUC3A, EPO, MUC1, TFRC, BAX, ABCB1, NR3C1, BNIP3, RECK, TGFB3, ASS1, NR4A1, MYOCD, EGLN3, TERT, SDHB, BACE1, ZNF217, CCND1, VEGFA, CXCL12, HIF1A2VHL, SDHB
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
RETYES5TFAP2C, SOX9, ESR1, SOX10, FOXA10
VHLYES1HIF1A0
GDNFYES2NFKB1, EGR10
SDHBYES4NRF1, NFE2L2, PLAGL1, HIF1A0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TMEM127KIF1BNo1ELAVL1
TMEM127VHLNo1ELAVL1
KIF1BVHLNo4PARD6A, PSMC3, ELAVL1, APP
MAXRETNo1HSP90AA1
MAXVHLNo12HSPA1A, HNRNPU, HSP90AA1, HNRNPH2, TUBA1A, SAP130, COPS5, EPAS1, KAT5, EP300, MYC, HIF1A
MAXGDNFNo1COPS5
MAXSDHBNo1COPS5
RETVHLNo2HNRNPD, HSP90AA1
RETGDNFNo1GFRA1
VHLGDNFNo1COPS5
VHLSDHBNo3SPRY2, CUL2, COPS5
GDNFSDHBNo1COPS5

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MAXRETNo-1MAPK14
MAXVHLNo-11EP300, HDAC1, HDAC2, TP53, CLU, MXI1, HSP90AA1, IREB2, KAT5, GSK3B, MYC
MAXGDNFNo-1KAT5
RETVHLNo-3UBC, PTPRJ, CDH1
RETGDNFYesactivation, binding38PTPN11, RASA1, SHANK3, GRB7, PXN, CTNND1, CREB1, NRTN, RAP1A, PRKACA, CTNNA1, MAPK8, CRK, GFRA2, PIK3CA, CTNNB1, SOS1, SHC1, PRKCA, HRAS, CDH1, GRB2, DOK1, SRC, GAB1, NCK1, PSPN, PDLIM7, PAX2, IRS1, GRB10, PIK3R1, BCAR1, DOK6, GFRA1, FRS2, DOK4, DOK5
RETSDHBNo-1UBC
VHLGDNFNo-2KAT5, CDH1
VHLSDHBNo-1UBC
SDHBSDHDYesbinding2SDHC, SDHA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
RETGDNFYes2RET, GDNF

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
SDHBSDHDyes, complexComponents of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathways in cancerhsa052003.983MAX, VHL, RET
Parkinson's diseasehsa050125.592SDHD, SDHB
Oxidative phosphorylationhsa001905.692SDHD, SDHB
Metabolic pathwayshsa011002.492SDHD, SDHB
Carbon metabolismhsa012006.032SDHD, SDHB
Citrate cycle (TCA cycle)hsa000207.862SDHD, SDHB
Huntington's diseasehsa050165.172SDHD, SDHB
Alzheimer's diseasehsa050105.342SDHD, SDHB
Non-alcoholic fatty liver disease (NAFLD)hsa049325.512SDHD, SDHB

NET-GE enrichment

Term New enriched termICP valueGenes
Citrate cycle (TCA cycle) (hsa00020) -7.860.006SDHD, SDHB
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Respiratory electron transportR-HSA-6111056.442SDHD, SDHB
Pyruvate metabolism and Citric Acid (TCA) cycleR-HSA-714067.562SDHD, SDHB
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-1632006.122SDHD, SDHB
Citric acid cycle (TCA cycle)R-HSA-714038.732SDHD, SDHB
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.712SDHD, SDHB
MetabolismR-HSA-14307282.342SDHD, SDHB

NET-GE enrichment

Term New enriched termICP valueGenes
Respiratory electron transport (R-HSA-611105) -6.440.033SDHD, SDHB
Pyruvate metabolism and Citric Acid (TCA) cycle (R-HSA-71406) -7.560.007SDHD, SDHB
Citric acid cycle (TCA cycle) (R-HSA-71403) -8.730.001SDHD, SDHB
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.188VHL, SDHB, RET, TMEM127, GDNF, MAX, SDHD, KIF1B
protein binding (GO:0005515) 0.467VHL, SDHB, RET, TMEM127, GDNF, MAX, KIF1B
catalytic activity (GO:0003824) 1.055VHL, KIF1B, RET, SDHD, SDHB
organic cyclic compound binding (GO:0097159) 1.054MAX, SDHD, RET, KIF1B
heterocyclic compound binding (GO:1901363) 1.064MAX, RET, SDHD, KIF1B
cation binding (GO:0043169) 1.43SDHD, RET, SDHB
metal ion binding (GO:0046872) 1.413SDHD, RET, SDHB
ion binding (GO:0043167) 1.363SDHD, RET, SDHB
Ras guanyl-nucleotide exchange factor activity (GO:0005088) 4.312RET, GDNF
purine ribonucleoside triphosphate binding (GO:0035639) 2.222RET, KIF1B
guanyl-nucleotide exchange factor activity (GO:0005085) 4.022RET, GDNF
enzyme binding (GO:0019899) 2.272VHL, TMEM127
molecular function regulator (GO:0098772) 2.512RET, GDNF
nucleoside phosphate binding (GO:1901265) 1.962RET, KIF1B
oxidoreductase activity (GO:0016491) 3.122SDHD, SDHB
succinate dehydrogenase activity (GO:0000104) 8.132SDHD, SDHB
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) 5.662SDHD, SDHB
nucleotide binding (GO:0000166) 1.962RET, KIF1B
transferase activity (GO:0016740) 1.952VHL, RET
purine nucleoside binding (GO:0001883) 2.222RET, KIF1B
ribonucleoside binding (GO:0032549) 2.222RET, KIF1B
purine nucleotide binding (GO:0017076) 2.192RET, KIF1B
nucleoside binding (GO:0001882) 2.212RET, KIF1B
identical protein binding (GO:0042802) 2.632MAX, GDNF
protein homodimerization activity (GO:0042803) 3.162MAX, GDNF
small molecule binding (GO:0036094) 1.892RET, KIF1B
cofactor binding (GO:0048037) 4.162SDHD, SDHB
ubiquinone binding (GO:0048039) 8.352SDHD, SDHB
quinone binding (GO:0048038) 6.912SDHD, SDHB
electron carrier activity (GO:0009055) 4.972SDHD, SDHB
adenyl nucleotide binding (GO:0030554) 2.42RET, KIF1B
carbohydrate derivative binding (GO:0097367) 2.032RET, KIF1B
adenyl ribonucleotide binding (GO:0032559) 2.412RET, KIF1B
ATP binding (GO:0005524) 2.432RET, KIF1B
purine ribonucleotide binding (GO:0032555) 2.22RET, KIF1B
protein dimerization activity (GO:0046983) 2.722MAX, GDNF
purine ribonucleoside binding (GO:0032550) 2.222RET, KIF1B
ribonucleotide binding (GO:0032553) 2.192RET, KIF1B

NET-GE enrichment

Term New enriched termICP valueGenes
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) -5.660.032SDHD, SDHB
succinate dehydrogenase activity (GO:0000104) -8.130.0SDHD, SDHB
ubiquinone binding (GO:0048039) -8.350.0SDHD, SDHB
quinone binding (GO:0048038) -6.910.015SDHD, SDHB
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.268VHL, SDHB, RET, TMEM127, GDNF, MAX, SDHD, KIF1B
single-organism cellular process (GO:0044763) 0.657VHL, SDHB, RET, GDNF, MAX, SDHD, KIF1B
single-organism process (GO:0044699) 0.487VHL, SDHB, RET, GDNF, MAX, SDHD, KIF1B
primary metabolic process (GO:0044238) 0.696VHL, GDNF, RET, SDHB, MAX, SDHD
metabolic process (GO:0008152) 0.586VHL, GDNF, RET, SDHB, MAX, SDHD
cellular metabolic process (GO:0044237) 0.696VHL, GDNF, RET, SDHB, MAX, SDHD
organic substance metabolic process (GO:0071704) 0.636VHL, GDNF, RET, SDHB, MAX, SDHD
cellular component organization (GO:0016043) 1.245VHL, MAX, TMEM127, RET, GDNF
biological regulation (GO:0065007) 0.395VHL, MAX, TMEM127, RET, GDNF
regulation of biological process (GO:0050789) 0.455VHL, MAX, TMEM127, RET, GDNF
cellular component organization or biogenesis (GO:0071840) 1.225VHL, MAX, TMEM127, RET, GDNF
regulation of cellular process (GO:0050794) 0.55VHL, MAX, TMEM127, RET, GDNF
developmental process (GO:0032502) 1.364MAX, VHL, RET, GDNF
single-organism metabolic process (GO:0044710) 1.634RET, SDHD, GDNF, SDHB
regulation of metabolic process (GO:0019222) 1.024VHL, MAX, RET, GDNF
cellular macromolecule metabolic process (GO:0044260) 0.934VHL, MAX, RET, GDNF
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434MAX, VHL, RET, GDNF
regulation of biosynthetic process (GO:0009889) 1.374VHL, MAX, RET, GDNF
regulation of cellular metabolic process (GO:0031323) 1.074VHL, MAX, RET, GDNF
regulation of RNA metabolic process (GO:0051252) 1.524MAX, VHL, RET, GDNF
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464MAX, VHL, RET, GDNF
regulation of nucleic acid-templated transcription (GO:1903506) 1.554VHL, MAX, RET, GDNF
macromolecule metabolic process (GO:0043170) 0.834VHL, MAX, RET, GDNF
regulation of cellular biosynthetic process (GO:0031326) 1.384MAX, VHL, RET, GDNF
regulation of transcription, DNA-templated (GO:0006355) 1.564VHL, MAX, RET, GDNF
regulation of macromolecule biosynthetic process (GO:0010556) 1.434MAX, VHL, RET, GDNF
regulation of nitrogen compound metabolic process (GO:0051171) 1.364MAX, VHL, RET, GDNF
regulation of RNA biosynthetic process (GO:2001141) 1.554VHL, MAX, RET, GDNF
regulation of macromolecule metabolic process (GO:0060255) 1.084VHL, MAX, RET, GDNF
negative regulation of biological process (GO:0048519) 1.334MAX, VHL, TMEM127, GDNF
regulation of gene expression (GO:0010468) 1.374MAX, VHL, RET, GDNF
regulation of primary metabolic process (GO:0080090) 1.084VHL, MAX, RET, GDNF
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563VHL, RET, GDNF
positive regulation of metabolic process (GO:0009893) 1.743VHL, RET, GDNF
positive regulation of biosynthetic process (GO:0009891) 2.293VHL, RET, GDNF
positive regulation of cellular metabolic process (GO:0031325) 1.813VHL, RET, GDNF
regulation of response to stimulus (GO:0048583) 1.543TMEM127, RET, GDNF
movement of cell or subcellular component (GO:0006928) 2.613RET, GDNF, KIF1B
positive regulation of gene expression (GO:0010628) 2.353VHL, RET, GDNF
regulation of signaling (GO:0023051) 1.723TMEM127, RET, GDNF
regulation of cell differentiation (GO:0045595) 2.423VHL, RET, GDNF
anatomical structure morphogenesis (GO:0009653) 2.533VHL, RET, GDNF
regulation of apoptotic process (GO:0042981) 2.53VHL, RET, GDNF
cellular protein metabolic process (GO:0044267) 1.633VHL, RET, GDNF
cellular response to stimulus (GO:0051716) 1.973VHL, MAX, RET
regulation of cell communication (GO:0010646) 1.733TMEM127, RET, GDNF
positive regulation of macromolecule metabolic process (GO:0010604) 1.813VHL, RET, GDNF
regulation of signal transduction (GO:0009966) 1.843TMEM127, RET, GDNF
cellular developmental process (GO:0048869) 1.823VHL, RET, GDNF
positive regulation of cellular biosynthetic process (GO:0031328) 2.33VHL, RET, GDNF
regulation of programmed cell death (GO:0043067) 2.493VHL, RET, GDNF
positive regulation of RNA metabolic process (GO:0051254) 2.513VHL, RET, GDNF
positive regulation of biological process (GO:0048518) 1.23VHL, RET, GDNF
regulation of biological quality (GO:0065008) 1.683VHL, RET, GDNF
regulation of cell proliferation (GO:0042127) 2.413VHL, TMEM127, GDNF
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353VHL, RET, GDNF
cellular protein modification process (GO:0006464) 1.793VHL, RET, GDNF
single-organism developmental process (GO:0044767) 1.493VHL, RET, GDNF
response to stress (GO:0006950) 1.83VHL, MAX, RET
protein modification process (GO:0036211) 1.793VHL, RET, GDNF
positive regulation of transcription, DNA-templated (GO:0045893) 2.563VHL, RET, GDNF
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293VHL, RET, GDNF
positive regulation of cell differentiation (GO:0045597) 3.013VHL, RET, GDNF
protein metabolic process (GO:0019538) 1.453VHL, RET, GDNF
response to stimulus (GO:0050896) 1.223VHL, MAX, RET
anatomical structure development (GO:0048856) 1.583MAX, RET, GDNF
regulation of cell death (GO:0010941) 2.433VHL, RET, GDNF
macromolecule modification (GO:0043412) 1.733VHL, RET, GDNF
positive regulation of RNA biosynthetic process (GO:1902680) 2.543VHL, RET, GDNF
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393VHL, RET, GDNF
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243VHL, MAX, GDNF
negative regulation of cellular process (GO:0048523) 1.413VHL, TMEM127, GDNF
positive regulation of cellular process (GO:0048522) 1.33VHL, RET, GDNF
regulation of extrinsic apoptotic signaling pathway (GO:2001236) 4.692RET, GDNF
regulation of apoptotic signaling pathway (GO:2001233) 3.832RET, GDNF
negative regulation of response to stimulus (GO:0048585) 2.522TMEM127, GDNF
regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001239) 5.862RET, GDNF
small molecule metabolic process (GO:0044281) 2.382SDHD, SDHB
signal transduction by protein phosphorylation (GO:0023014) 3.792RET, GDNF
negative regulation of macromolecule metabolic process (GO:0010605) 2.012MAX, VHL
negative regulation of signal transduction (GO:0009968) 2.752TMEM127, GDNF
MAPK cascade (GO:0000165) 3.912RET, GDNF
kidney development (GO:0001822) 4.792RET, GDNF
animal organ development (GO:0048513) 2.532RET, GDNF
positive regulation of molecular function (GO:0044093) 2.232RET, GDNF
negative regulation of cell death (GO:0060548) 2.952VHL, GDNF
neural crest cell migration (GO:0001755) 5.762RET, GDNF
tube formation (GO:0035148) 4.982RET, GDNF
response to organic substance (GO:0010033) 2.22MAX, RET
oxidation-reduction process (GO:0055114) 2.912SDHD, SDHB
single-multicellular organism process (GO:0044707) 1.782RET, GDNF
cell motility (GO:0048870) 3.022RET, GDNF
cellular response to stress (GO:0033554) 2.512MAX, VHL
retina development in camera-type eye (GO:0060041) 5.512MAX, RET
regulation of cell morphogenesis (GO:0022604) 3.42RET, GDNF
negative regulation of metabolic process (GO:0009892) 1.932MAX, VHL
regulation of anatomical structure morphogenesis (GO:0022603) 2.792RET, GDNF
positive regulation of kidney development (GO:0090184) 6.022RET, GDNF
regulation of kidney development (GO:0090183) 5.722RET, GDNF
enteric nervous system development (GO:0048484) 7.332RET, GDNF
intracellular signal transduction (GO:0035556) 2.392RET, GDNF
cell morphogenesis (GO:0000902) 4.352VHL, GDNF
positive regulation of hydrolase activity (GO:0051345) 2.912RET, GDNF
regulation of molecular function (GO:0065009) 1.782RET, GDNF
cell migration (GO:0016477) 3.122RET, GDNF
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012RET, GDNF
positive regulation of cellular component organization (GO:0051130) 2.682RET, GDNF
regulation of developmental process (GO:0050793) 2.12RET, GDNF
regulation of catalytic activity (GO:0050790) 1.972RET, GDNF
tissue development (GO:0009888) 3.272RET, GDNF
programmed cell death (GO:0012501) 3.12MAX, KIF1B
response to oxygen-containing compound (GO:1901700) 2.572MAX, RET
regulation of multicellular organismal process (GO:0051239) 1.872RET, GDNF
regulation of intracellular signal transduction (GO:1902531) 2.312TMEM127, RET
epithelial tube formation (GO:0072175) 6.362RET, GDNF
regulation of hydrolase activity (GO:0051336) 2.532RET, GDNF
phosphorylation (GO:0016310) 2.632RET, GDNF
regulation of cellular component organization (GO:0051128) 2.012RET, GDNF
negative regulation of signaling (GO:0023057) 2.652TMEM127, GDNF
negative regulation of cell communication (GO:0010648) 2.662TMEM127, GDNF
cellular response to chemical stimulus (GO:0070887) 2.572MAX, RET
cell communication (GO:0007154) 3.042MAX, KIF1B
ameboidal-type cell migration (GO:0001667) 4.712RET, GDNF
regulation of GTPase activity (GO:0043087) 3.212RET, GDNF
positive regulation of catalytic activity (GO:0043085) 2.42RET, GDNF
positive regulation of multicellular organismal process (GO:0051240) 2.492RET, GDNF
regulation of cell development (GO:0060284) 3.012RET, GDNF
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.912RET, GDNF
proteolysis (GO:0006508) 2.732VHL, RET
negative regulation of cell proliferation (GO:0008285) 3.262VHL, TMEM127
multicellular organismal process (GO:0032501) 1.452RET, GDNF
positive regulation of cell development (GO:0010720) 3.572RET, GDNF
epithelium development (GO:0060429) 4.572RET, GDNF
mesonephric epithelium development (GO:0072163) 5.82RET, GDNF
mesonephric tubule development (GO:0072164) 5.822RET, GDNF
locomotion (GO:0040011) 2.912RET, GDNF
metanephros development (GO:0001656) 6.022RET, GDNF
ureteric bud development (GO:0001657) 5.972RET, GDNF
regulation of localization (GO:0032879) 1.942RET, GDNF
organic acid metabolic process (GO:0006082) 3.012SDHD, SDHB
positive regulation of developmental process (GO:0051094) 2.772RET, GDNF
positive regulation of metanephros development (GO:0072216) 7.092RET, GDNF
negative regulation of gene expression (GO:0010629) 2.482MAX, VHL
regulation of metanephros development (GO:0072215) 6.592RET, GDNF
system development (GO:0048731) 2.922RET, GDNF
signal transduction (GO:0007165) 1.282RET, GDNF
tricarboxylic acid cycle (GO:0006099) 6.332SDHD, SDHB
cell death (GO:0008219) 3.052MAX, KIF1B
kidney epithelium development (GO:0072073) 5.542RET, GDNF
cellular component morphogenesis (GO:0032989) 3.52VHL, GDNF
cellular response to organic substance (GO:0071310) 2.782MAX, RET
negative regulation of apoptotic process (GO:0043066) 3.042VHL, GDNF
tissue morphogenesis (GO:0048729) 3.872RET, GDNF
negative regulation of programmed cell death (GO:0043069) 3.022VHL, GDNF
protein phosphorylation (GO:0006468) 2.892RET, GDNF
apoptotic process (GO:0006915) 3.142MAX, KIF1B
response to chemical (GO:0042221) 1.982MAX, RET
tube development (GO:0035295) 4.412RET, GDNF
positive regulation of GTPase activity (GO:0043547) 3.282RET, GDNF
embryonic epithelial tube formation (GO:0001838) 6.42RET, GDNF
cellular response to oxygen-containing compound (GO:1901701) 3.222MAX, RET
nervous system development (GO:0007399) 3.532RET, GDNF
phosphate-containing compound metabolic process (GO:0006796) 2.162RET, GDNF
regulation of multicellular organismal development (GO:2000026) 2.312RET, GDNF
phosphorus metabolic process (GO:0006793) 2.152RET, GDNF

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of kidney development (GO:0090183) -5.720.032VHL, RET, GDNF
embryonic epithelial tube formation (GO:0001838) -6.40.027RET, GDNF
tricarboxylic acid cycle (GO:0006099) -6.330.033SDHD, SDHB
regulation of metanephros development (GO:0072215) -6.590.021RET, GDNF
enteric nervous system development (GO:0048484) -7.330.048RET, GDNF
lymphocyte migration into lymphoid organs (GO:0097021) NEW8.630.002RET, GDNF
metanephros development (GO:0001656) -6.020.049RET, GDNF
neural crest cell migration (GO:0001755) -5.760.049RET, GDNF
Peyers patch morphogenesis (GO:0061146) NEW8.630.005RET, GDNF
epithelial tube formation (GO:0072175) -6.360.029RET, GDNF
autonomic nervous system development (GO:0048483) NEW8.120.017RET, GDNF
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.118VHL, SDHB, RET, TMEM127, GDNF, MAX, SDHD, KIF1B
intracellular part (GO:0044424) 0.287VHL, RET, TMEM127, SDHB, MAX, SDHD, KIF1B
intracellular organelle (GO:0043229) 0.517VHL, RET, TMEM127, SDHB, MAX, SDHD, KIF1B
membrane-bounded organelle (GO:0043227) 0.477VHL, RET, TMEM127, SDHB, MAX, SDHD, KIF1B
intracellular membrane-bounded organelle (GO:0043231) 0.67VHL, RET, TMEM127, SDHB, MAX, SDHD, KIF1B
organelle (GO:0043226) 0.47VHL, RET, TMEM127, SDHB, MAX, SDHD, KIF1B
protein complex (GO:0043234) 1.516VHL, RET, SDHB, MAX, SDHD, KIF1B
macromolecular complex (GO:0032991) 1.356VHL, RET, SDHB, MAX, SDHD, KIF1B
membrane (GO:0016020) 0.686VHL, RET, TMEM127, SDHB, SDHD, KIF1B
intracellular organelle part (GO:0044446) 0.816VHL, RET, SDHB, MAX, SDHD, KIF1B
cytoplasmic part (GO:0044444) 0.826VHL, RET, TMEM127, SDHB, SDHD, KIF1B
organelle part (GO:0044422) 0.796VHL, RET, SDHB, MAX, SDHD, KIF1B
cytoplasm (GO:0005737) 1.015VHL, MAX, TMEM127, RET, KIF1B
membrane part (GO:0044425) 0.954TMEM127, SDHD, SDHB, RET
catalytic complex (GO:1902494) 2.94VHL, MAX, SDHD, SDHB
mitochondrion (GO:0005739) 2.424VHL, SDHD, KIF1B, SDHB
organelle membrane (GO:0031090) 1.974KIF1B, RET, SDHD, SDHB
integral component of membrane (GO:0016021) 1.143TMEM127, SDHD, RET
nucleoplasm (GO:0005654) 1.893MAX, VHL, SDHB
neuron part (GO:0097458) 2.643MAX, RET, KIF1B
nuclear part (GO:0044428) 1.553MAX, VHL, SDHB
neuron projection (GO:0043005) 3.123MAX, RET, KIF1B
plasma membrane (GO:0005886) 1.393TMEM127, RET, SDHB
cell projection (GO:0042995) 2.473MAX, RET, KIF1B
intrinsic component of membrane (GO:0031224) 1.133TMEM127, SDHD, RET
fumarate reductase complex (GO:0045283) 8.422SDHD, SDHB
dendrite (GO:0030425) 3.922MAX, RET
oxidoreductase complex (GO:1990204) 5.192SDHD, SDHB
inner mitochondrial membrane protein complex (GO:0098800) 5.012SDHD, SDHB
vesicle (GO:0031982) 1.642KIF1B, SDHB
membrane protein complex (GO:0098796) 2.842SDHD, SDHB
vacuole (GO:0005773) 2.922TMEM127, RET
nucleus (GO:0005634) 1.072VHL, MAX
respiratory chain complex (GO:0098803) 5.472SDHD, SDHB
succinate dehydrogenase complex (GO:0045281) 8.422SDHD, SDHB
membrane-bounded vesicle (GO:0031988) 1.712KIF1B, SDHB
mitochondrial membrane part (GO:0044455) 4.542SDHD, SDHB
mitochondrial membrane (GO:0031966) 3.312SDHD, SDHB
transferase complex (GO:1990234) 3.322VHL, MAX
succinate dehydrogenase complex (ubiquinone) (GO:0045257) 8.422SDHD, SDHB
organelle inner membrane (GO:0019866) 3.562SDHD, SDHB
mitochondrial inner membrane (GO:0005743) 3.652SDHD, SDHB
mitochondrial part (GO:0044429) 2.922SDHD, SDHB
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) (GO:0005749) 8.422SDHD, SDHB
endosome (GO:0005768) 3.252TMEM127, RET
early endosome (GO:0005769) 4.342TMEM127, RET
mitochondrial protein complex (GO:0098798) 4.782SDHD, SDHB

NET-GE enrichment

Term New enriched termICP valueGenes
succinate dehydrogenase complex (ubiquinone) (GO:0045257) -8.420.0SDHD, SDHB
mitochondrial respiratory chain complex II (GO:0005749) -8.420.0SDHD, SDHB
fumarate reductase complex (GO:0045283) -8.420.0SDHD, SDHB
succinate dehydrogenase complex (GO:0045281) -8.420.0SDHD, SDHB
oxidoreductase complex (GO:1990204) -5.190.048SDHD, SDHB