Disease table of NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO OMIM ID: 182940

Gene-disease associations table

GeneAssociated with NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CCL2OMIMHGNC link17q123609423, 607948, 182940
FUZOMIMHGNC link19q13.331182940
CELSR1HUMSAVARHGNC link22q13.311182940
SCRIBHUMSAVARHGNC link8q24.31182940
TOMIMHGNC link6q272182940, 615709
VANGL1OMIM, HUMSAVARHGNC link1p13.12182940, 600145
VANGL2OMIM, HUMSAVARHGNC link1q23.21182940
DACT1HUMSAVARHGNC link14q23.11182940

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
12VANGL1, VANGL2
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CCL2YES17SP1, XBP1, NFAT5, NFKB1, PREB, HEY1, HDAC2, NFIC, NR1I2, ATF4, JUN, IRF3, RELA, APEX1, MAML1, REL, STAT10
TYES1POU5F10
DACT1YES1NKX2-50
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SCRIBVANGL1No2TMEM17, CCDC8
SCRIBVANGL2No2NTRK1, TMEM17
SCRIBDACT1No1PPP1CC
VANGL1VANGL2No4SPRY2, TMEM216, TMEM17, LUC7L

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
CELSR1SCRIBNo-1VANGL2
CELSR1VANGL1Yesbinding0
CELSR1VANGL2Yesbinding0
CELSR1DACT1No-1VANGL2
SCRIBVANGL2Yesbinding0
SCRIBDACT1No-1VANGL2
TDACT1No-2LEF1, CTNNB1
VANGL1VANGL2No-17CELSR3, DLG2, PRICKLE1, CELSR2, DVL2, DLG3, DVL1, FZD6, FZD3, CELSR1, PRICKLE3, FZD1, DLG4, WNT11, PRICKLE2, DLG1, DVL3
VANGL1DACT1No-3DVL3, DVL1, DVL2
VANGL2DACT1Yesbinding3DVL3, DVL1, DVL2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
SCRIBVANGL2YesSCRIB-VANGL2 complex0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Wnt signaling pathwayhsa043105.492VANGL2, VANGL1

NET-GE enrichment

Term New enriched termICP valueGenes
Wnt signaling pathway (hsa04310) -5.490.001VANGL2, T, DACT1, VANGL1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.785DACT1, VANGL2, SCRIB, CCL2, FUZ
Signaling by WntR-HSA-1957214.793VANGL2, DACT1, SCRIB
beta-catenin independent WNT signalingR-HSA-38584945.832VANGL2, SCRIB
Asymmetric localization of PCP proteinsR-HSA-46088707.012VANGL2, SCRIB
PCP/CE pathwayR-HSA-40864006.472VANGL2, SCRIB

NET-GE enrichment

Term New enriched termICP valueGenes
beta-catenin independent WNT signaling (R-HSA-3858494) -5.830.04VANGL2, DACT1, SCRIB
Signaling by Wnt (R-HSA-195721) -4.790.008VANGL2, T, DACT1, SCRIB
Asymmetric localization of PCP proteins (R-HSA-4608870) -7.010.001VANGL2, DACT1, SCRIB
PCP/CE pathway (R-HSA-4086400) -6.470.023VANGL2, DACT1, SCRIB
Signal Transduction (R-HSA-162582) -1.780.039DACT1, VANGL2, CCL2, SCRIB, FUZ
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.187DACT1, SCRIB, VANGL2, CCL2, CELSR1, T, VANGL1
protein binding (GO:0005515) 0.467DACT1, SCRIB, VANGL2, CCL2, CELSR1, T, VANGL1
RNA polymerase II transcription factor binding (GO:0001085) 5.082T, DACT1
transcription factor binding (GO:0008134) 3.462T, DACT1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.368VANGL2, DACT1, SCRIB, CELSR1, CCL2, FUZ, T, VANGL1
anatomical structure development (GO:0048856) 1.588VANGL2, DACT1, SCRIB, CELSR1, CCL2, FUZ, T, VANGL1
regulation of cellular process (GO:0050794) 0.58VANGL2, DACT1, SCRIB, CELSR1, CCL2, FUZ, T, VANGL1
single-organism developmental process (GO:0044767) 1.498VANGL2, DACT1, SCRIB, CELSR1, CCL2, FUZ, T, VANGL1
biological regulation (GO:0065007) 0.398VANGL2, DACT1, SCRIB, CELSR1, CCL2, FUZ, T, VANGL1
regulation of biological process (GO:0050789) 0.458VANGL2, DACT1, SCRIB, CELSR1, CCL2, FUZ, T, VANGL1
single-organism process (GO:0044699) 0.488VANGL2, DACT1, SCRIB, CELSR1, CCL2, FUZ, T, VANGL1
multicellular organismal process (GO:0032501) 1.457DACT1, CELSR1, SCRIB, VANGL2, FUZ, T, VANGL1
anatomical structure morphogenesis (GO:0009653) 2.537DACT1, CELSR1, SCRIB, VANGL2, CCL2, FUZ, T
multicellular organism development (GO:0007275) 2.547DACT1, CELSR1, SCRIB, VANGL2, FUZ, T, VANGL1
single-multicellular organism process (GO:0044707) 1.787DACT1, CELSR1, SCRIB, VANGL2, FUZ, T, VANGL1
embryonic morphogenesis (GO:0048598) 3.726CELSR1, DACT1, VANGL2, SCRIB, FUZ, T
regulation of multicellular organismal process (GO:0051239) 1.876CELSR1, DACT1, VANGL2, CCL2, FUZ, VANGL1
regulation of anatomical structure morphogenesis (GO:0022603) 2.796CELSR1, DACT1, VANGL2, CCL2, FUZ, VANGL1
regulation of developmental process (GO:0050793) 2.16CELSR1, DACT1, VANGL2, CCL2, FUZ, VANGL1
cellular process (GO:0009987) 0.266CELSR1, SCRIB, VANGL2, CCL2, FUZ, T
regulation of multicellular organismal development (GO:2000026) 2.316CELSR1, DACT1, VANGL2, CCL2, FUZ, VANGL1
signal transduction (GO:0007165) 1.286DACT1, VANGL2, CCL2, CELSR1, T, VANGL1
cell surface receptor signaling pathway (GO:0007166) 2.096DACT1, VANGL2, CCL2, CELSR1, T, VANGL1
positive regulation of biological process (GO:0048518) 1.26SCRIB, DACT1, VANGL2, CCL2, FUZ, T
single-organism cellular process (GO:0044763) 0.656CELSR1, SCRIB, VANGL2, CCL2, FUZ, T
anatomical structure formation involved in morphogenesis (GO:0048646) 3.016CELSR1, SCRIB, VANGL2, CCL2, FUZ, T
positive regulation of cellular process (GO:0048522) 1.36SCRIB, DACT1, VANGL2, CCL2, FUZ, T
locomotion (GO:0040011) 2.915CELSR1, VANGL2, T, SCRIB, CCL2
tube formation (GO:0035148) 4.985CELSR1, VANGL2, T, FUZ, SCRIB
cell migration (GO:0016477) 3.125CELSR1, VANGL2, T, CCL2, SCRIB
positive regulation of metabolic process (GO:0009893) 1.745DACT1, VANGL2, T, SCRIB, CCL2
regulation of metabolic process (GO:0019222) 1.025DACT1, VANGL2, T, CCL2, SCRIB
cell motility (GO:0048870) 3.025CELSR1, VANGL2, T, CCL2, SCRIB
regulation of macromolecule metabolic process (GO:0060255) 1.085DACT1, VANGL2, T, SCRIB, CCL2
response to stimulus (GO:0050896) 1.225CELSR1, VANGL2, T, SCRIB, CCL2
Wnt signaling pathway (GO:0016055) 3.885CELSR1, VANGL2, T, DACT1, VANGL1
regulation of cellular metabolic process (GO:0031323) 1.075DACT1, VANGL2, T, CCL2, SCRIB
positive regulation of cellular metabolic process (GO:0031325) 1.815DACT1, VANGL2, T, CCL2, SCRIB
regulation of cellular component organization (GO:0051128) 2.015CELSR1, VANGL2, DACT1, CCL2, FUZ
tube closure (GO:0060606) 5.365CELSR1, VANGL2, T, FUZ, SCRIB
regulation of signaling (GO:0023051) 1.725DACT1, VANGL2, CCL2, SCRIB, FUZ
negative regulation of biological process (GO:0048519) 1.335DACT1, FUZ, T, CCL2, SCRIB
neural tube closure (GO:0001843) 5.385CELSR1, VANGL2, T, FUZ, SCRIB
movement of cell or subcellular component (GO:0006928) 2.615CELSR1, VANGL2, T, SCRIB, CCL2
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114) 3.795CELSR1, VANGL2, T, DACT1, VANGL1
negative regulation of cellular process (GO:0048523) 1.415DACT1, FUZ, T, CCL2, SCRIB
positive regulation of macromolecule metabolic process (GO:0010604) 1.815DACT1, VANGL2, T, SCRIB, CCL2
morphogenesis of an epithelium (GO:0002009) 4.084VANGL2, T, CELSR1, SCRIB
organ morphogenesis (GO:0009887) 3.554VANGL2, T, FUZ, CCL2
protein localization (GO:0008104) 2.364CELSR1, VANGL2, FUZ, SCRIB
regulation of cell communication (GO:0010646) 1.734DACT1, FUZ, VANGL2, CCL2
tissue morphogenesis (GO:0048729) 3.874VANGL2, T, CELSR1, SCRIB
regulation of establishment of planar polarity (GO:0090175) 5.024CELSR1, VANGL2, DACT1, VANGL1
regulation of signal transduction (GO:0009966) 1.844DACT1, FUZ, VANGL2, CCL2
regulation of response to stimulus (GO:0048583) 1.544DACT1, FUZ, VANGL2, CCL2
response to wounding (GO:0009611) 4.394CELSR1, VANGL2, SCRIB, CCL2
cellular component organization (GO:0016043) 1.244VANGL2, SCRIB, CCL2, FUZ
positive regulation of signaling (GO:0023056) 2.414DACT1, VANGL2, SCRIB, CCL2
regulation of primary metabolic process (GO:0080090) 1.084VANGL2, T, DACT1, CCL2
response to stress (GO:0006950) 1.84CELSR1, VANGL2, SCRIB, CCL2
regulation of organ morphogenesis (GO:2000027) 4.224CELSR1, VANGL2, DACT1, VANGL1
positive regulation of molecular function (GO:0044093) 2.234DACT1, VANGL2, CCL2, SCRIB
regulation of molecular function (GO:0065009) 1.784DACT1, VANGL2, CCL2, SCRIB
macromolecule localization (GO:0033036) 2.344CELSR1, VANGL2, FUZ, SCRIB
localization (GO:0051179) 1.44CELSR1, VANGL2, FUZ, SCRIB
cellular component organization or biogenesis (GO:0071840) 1.224VANGL2, SCRIB, CCL2, FUZ
(GO:1905330) 4.564CELSR1, VANGL2, DACT1, VANGL1
asymmetric protein localization (GO:0008105) 6.843VANGL2, CELSR1, SCRIB
regulation of phosphate metabolic process (GO:0019220) 2.353VANGL2, DACT1, CCL2
metabolic process (GO:0008152) 0.583VANGL2, T, CCL2
regulation of organelle organization (GO:0033043) 2.723CELSR1, VANGL2, FUZ
cell projection organization (GO:0030030) 3.143VANGL2, FUZ, SCRIB
negative regulation of response to stimulus (GO:0048585) 2.523FUZ, DACT1, CCL2
positive regulation of response to stimulus (GO:0048584) 2.183VANGL2, DACT1, CCL2
molting cycle process (GO:0022404) 5.543CELSR1, VANGL2, FUZ
hair cycle process (GO:0022405) 5.543CELSR1, VANGL2, FUZ
establishment of tissue polarity (GO:0007164) 6.843CELSR1, VANGL2, FUZ
intracellular signal transduction (GO:0035556) 2.393VANGL2, CELSR1, CCL2
positive regulation of cell communication (GO:0010647) 2.413VANGL2, DACT1, CCL2
positive regulation of catalytic activity (GO:0043085) 2.43VANGL2, CCL2, SCRIB
regulation of MAPK cascade (GO:0043408) 3.223VANGL2, DACT1, CCL2
pattern specification process (GO:0007389) 3.793VANGL2, T, CELSR1
regulation of localization (GO:0032879) 1.943FUZ, DACT1, CCL2
cellular macromolecule metabolic process (GO:0044260) 0.933VANGL2, T, CCL2
positive regulation of signal transduction (GO:0009967) 2.53VANGL2, DACT1, CCL2
hair follicle development (GO:0001942) 6.023CELSR1, VANGL2, FUZ
regulation of protein metabolic process (GO:0051246) 1.933VANGL2, DACT1, CCL2
positive regulation of protein metabolic process (GO:0051247) 2.433VANGL2, DACT1, CCL2
organic substance metabolic process (GO:0071704) 0.633VANGL2, T, CCL2
positive regulation of cellular protein metabolic process (GO:0032270) 2.493VANGL2, DACT1, CCL2
regulation of protein modification process (GO:0031399) 2.323VANGL2, DACT1, CCL2
biological adhesion (GO:0022610) 2.813CELSR1, SCRIB, CCL2
regulation of cell proliferation (GO:0042127) 2.413FUZ, T, CCL2
organelle organization (GO:0006996) 2.023VANGL2, FUZ, CCL2
regulation of catalytic activity (GO:0050790) 1.973VANGL2, SCRIB, CCL2
regulation of biosynthetic process (GO:0009889) 1.373T, DACT1, CCL2
wound healing (GO:0042060) 5.133VANGL2, CELSR1, SCRIB
Wnt signaling pathway, planar cell polarity pathway (GO:0060071) 5.123VANGL2, CELSR1, VANGL1
regionalization (GO:0003002) 4.243VANGL2, T, CELSR1
regulation of embryonic development (GO:0045995) 4.983CELSR1, VANGL2, FUZ
cell adhesion (GO:0007155) 2.823CELSR1, CCL2, SCRIB
regulation of intracellular signal transduction (GO:1902531) 2.313VANGL2, DACT1, CCL2
establishment of planar polarity (GO:0001736) 6.93CELSR1, VANGL2, FUZ
non-canonical Wnt signaling pathway (GO:0035567) 4.793VANGL2, CELSR1, VANGL1
multi-organism process (GO:0051704) 2.653T, CCL2, SCRIB
regulation of phosphorylation (GO:0042325) 2.53VANGL2, DACT1, CCL2
regulation of phosphorus metabolic process (GO:0051174) 2.353VANGL2, DACT1, CCL2
regulation of cellular protein metabolic process (GO:0032268) 1.993VANGL2, DACT1, CCL2
anterior/posterior pattern specification (GO:0009952) 4.713VANGL2, T, CELSR1
regulation of response to stress (GO:0080134) 2.533VANGL2, DACT1, CCL2
regulation of Wnt signaling pathway (GO:0030111) 3.983FUZ, VANGL2, DACT1
cellular metabolic process (GO:0044237) 0.693VANGL2, T, CCL2
macromolecule metabolic process (GO:0043170) 0.833VANGL2, T, CCL2
regulation of macromolecule biosynthetic process (GO:0010556) 1.433T, DACT1, CCL2
cellular developmental process (GO:0048869) 1.823VANGL2, T, SCRIB
system development (GO:0048731) 2.923CELSR1, T, DACT1
regulation of protein phosphorylation (GO:0001932) 2.573VANGL2, DACT1, CCL2
regulation of intracellular protein transport (GO:0033157) 3.82DACT1, CCL2
positive regulation of intracellular transport (GO:0032388) 4.082DACT1, CCL2
regulation of transport (GO:0051049) 2.242DACT1, CCL2
regulation of intracellular transport (GO:0032386) 3.582DACT1, CCL2
Rho protein signal transduction (GO:0007266) 5.82VANGL2, CELSR1
establishment or maintenance of cell polarity (GO:0007163) 5.02VANGL2, SCRIB
establishment of body hair planar orientation (GO:0048105) 9.042VANGL2, CELSR1
establishment of body hair or bristle planar orientation (GO:0048104) 9.042VANGL2, CELSR1
cellular response to stimulus (GO:0051716) 1.972T, CCL2
negative regulation of cell cycle (GO:0045786) 3.672DACT1, SCRIB
negative regulation of signal transduction (GO:0009968) 2.752FUZ, DACT1
regulation of cytoskeleton organization (GO:0051493) 3.722VANGL2, CELSR1
cellular response to organic substance (GO:0071310) 2.782T, CCL2
interspecies interaction between organisms (GO:0044419) 3.082CCL2, SCRIB
animal organ development (GO:0048513) 2.532T, CCL2
cell differentiation (GO:0030154) 2.142T, SCRIB
chemotaxis (GO:0006935) 4.042SCRIB, CCL2
positive regulation of transport (GO:0051050) 2.92DACT1, CCL2
regulation of RNA biosynthetic process (GO:2001141) 1.552T, DACT1
response to organic substance (GO:0010033) 2.22T, CCL2
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 4.62T, CCL2
positive regulation of phosphorylation (GO:0042327) 2.92VANGL2, CCL2
establishment of planar polarity of embryonic epithelium (GO:0042249) 8.122VANGL2, CELSR1
negative regulation of signaling (GO:0023057) 2.652FUZ, DACT1
planar cell polarity pathway involved in neural tube closure (GO:0090179) 7.162VANGL2, CELSR1
regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) 7.022VANGL2, CELSR1
lateral sprouting involved in lung morphogenesis (GO:0060490) 9.042VANGL2, CELSR1
cilium organization (GO:0044782) 4.672VANGL2, FUZ
regulation of canonical Wnt signaling pathway (GO:0060828) 4.262FUZ, DACT1
regulation of cell morphogenesis (GO:0022604) 3.42FUZ, CCL2
cellular component assembly (GO:0022607) 2.142VANGL2, FUZ
negative regulation of metabolic process (GO:0009892) 1.932T, DACT1
regulation of protein targeting (GO:1903533) 4.02DACT1, CCL2
negative regulation of biosynthetic process (GO:0009890) 2.472T, DACT1
positive regulation of biosynthetic process (GO:0009891) 2.292T, CCL2
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242T, CCL2
negative regulation of gene expression (GO:0010629) 2.482T, DACT1
regulation of JNK cascade (GO:0046328) 4.652VANGL2, DACT1
positive regulation of protein transport (GO:0051222) 3.612DACT1, CCL2
regulation of protein transport (GO:0051223) 3.122DACT1, CCL2
regulation of apoptotic process (GO:0042981) 2.52CCL2, SCRIB
negative regulation of Wnt signaling pathway (GO:0030178) 4.442FUZ, DACT1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552T, DACT1
organic substance biosynthetic process (GO:1901576) 1.342VANGL2, T
establishment or maintenance of apical/basal cell polarity (GO:0035088) 6.152VANGL2, SCRIB
positive regulation of GTPase activity (GO:0043547) 3.282SCRIB, CCL2
positive regulation of hydrolase activity (GO:0051345) 2.912SCRIB, CCL2
post-anal tail morphogenesis (GO:0036342) 6.842VANGL2, T
regulation of biological quality (GO:0065008) 1.682DACT1, CCL2
G-protein coupled receptor signaling pathway (GO:0007186) 2.642CELSR1, CCL2
positive regulation of cellular component organization (GO:0051130) 2.682FUZ, CCL2
regulation of establishment of protein localization (GO:0070201) 3.022DACT1, CCL2
cilium assembly (GO:0042384) 4.772VANGL2, FUZ
cell-cell adhesion (GO:0098609) 3.342CELSR1, SCRIB
transport (GO:0006810) 1.512FUZ, SCRIB
tissue development (GO:0009888) 3.272T, DACT1
positive regulation of MAPK cascade (GO:0043410) 3.572VANGL2, CCL2
apical protein localization (GO:0045176) 7.242VANGL2, CELSR1
dichotomous subdivision of an epithelial terminal unit (GO:0060600) 7.432VANGL2, CELSR1
lateral sprouting from an epithelium (GO:0060601) 7.652VANGL2, CELSR1
negative regulation of macromolecule metabolic process (GO:0010605) 2.012T, DACT1
establishment of localization (GO:0051234) 1.482FUZ, SCRIB
regulation of hydrolase activity (GO:0051336) 2.532SCRIB, CCL2
taxis (GO:0042330) 4.032SCRIB, CCL2
inner ear receptor stereocilium organization (GO:0060122) 6.472VANGL2, SCRIB
regulation of cellular response to stress (GO:0080135) 3.42VANGL2, DACT1
regulation of transcription, DNA-templated (GO:0006355) 1.562T, DACT1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392T, CCL2
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242T, DACT1
regulation of cell motility (GO:2000145) 3.162FUZ, CCL2
negative regulation of cell motility (GO:2000146) 4.362FUZ, CCL2
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532T, DACT1
regulation of nitrogen compound metabolic process (GO:0051171) 1.362T, DACT1
regulation of actin cytoskeleton organization (GO:0032956) 4.092VANGL2, CELSR1
negative regulation of cellular component organization (GO:0051129) 3.352FUZ, DACT1
cellular component assembly involved in morphogenesis (GO:0010927) 4.292VANGL2, FUZ
regulation of cellular protein localization (GO:1903827) 3.432DACT1, CCL2
cellular biosynthetic process (GO:0044249) 1.372VANGL2, T
negative regulation of cell communication (GO:0010648) 2.662FUZ, DACT1
cellular response to chemical stimulus (GO:0070887) 2.572T, CCL2
positive regulation of intracellular signal transduction (GO:1902533) 2.952VANGL2, CCL2
establishment or maintenance of bipolar cell polarity (GO:0061245) 6.152VANGL2, SCRIB
positive regulation of establishment of protein localization (GO:1904951) 3.492DACT1, CCL2
regulation of GTPase activity (GO:0043087) 3.212SCRIB, CCL2
positive regulation of cellular protein localization (GO:1903829) 3.852DACT1, CCL2
regulation of protein localization (GO:0032880) 2.882DACT1, CCL2
astrocyte cell migration (GO:0043615) 7.942SCRIB, CCL2
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122T, DACT1
positive regulation of phosphorus metabolic process (GO:0010562) 2.782VANGL2, CCL2
negative regulation of multicellular organismal process (GO:0051241) 2.842FUZ, CCL2
regulation of cellular biosynthetic process (GO:0031326) 1.382T, DACT1
dichotomous subdivision of terminal units involved in lung branching (GO:0060448) 8.632VANGL2, CELSR1
epithelial tube morphogenesis (GO:0060562) 5.122VANGL2, SCRIB
positive regulation of cell proliferation (GO:0008284) 3.012T, CCL2
tube morphogenesis (GO:0035239) 4.352VANGL2, SCRIB
multicellular organismal reproductive process (GO:0048609) 3.352T, CCL2
cellular response to oxygen-containing compound (GO:1901701) 3.222T, CCL2
regulation of stress-activated protein kinase signaling cascade (GO:0070302) 4.442VANGL2, DACT1
regulation of actin filament-based process (GO:0032970) 3.972VANGL2, CELSR1
cellular response to lipid (GO:0071396) 3.962T, CCL2
negative regulation of locomotion (GO:0040013) 4.222FUZ, CCL2
regulation of nucleic acid-templated transcription (GO:1903506) 1.552T, DACT1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712T, DACT1
regulation of stress-activated MAPK cascade (GO:0032872) 4.452VANGL2, DACT1
cellular macromolecule biosynthetic process (GO:0034645) 1.662VANGL2, T
regulation of locomotion (GO:0040012) 3.122FUZ, CCL2
negative regulation of transcription, DNA-templated (GO:0045892) 2.752T, DACT1
response to acid chemical (GO:0001101) 4.052T, CCL2
viral process (GO:0016032) 3.152CCL2, SCRIB
multi-organism cellular process (GO:0044764) 3.142SCRIB, CCL2
organelle assembly (GO:0070925) 3.752VANGL2, FUZ
negative regulation of developmental process (GO:0051093) 3.172FUZ, CCL2
negative regulation of RNA metabolic process (GO:0051253) 2.662T, DACT1
regulation of RNA metabolic process (GO:0051252) 1.522T, DACT1
morphogenesis of embryonic epithelium (GO:0016331) 6.472T, SCRIB
positive regulation of protein modification process (GO:0031401) 2.72VANGL2, CCL2
regulation of cellular localization (GO:0060341) 3.032DACT1, CCL2
negative regulation of cellular biosynthetic process (GO:0031327) 2.492T, DACT1
cell projection assembly (GO:0030031) 4.192VANGL2, FUZ
negative regulation of cellular metabolic process (GO:0031324) 2.012T, DACT1
cellular response to acid chemical (GO:0071229) 4.672T, CCL2
negative regulation of cell migration (GO:0030336) 4.412FUZ, CCL2
regulation of mitotic cell cycle (GO:0007346) 3.712DACT1, SCRIB
regulation of cell death (GO:0010941) 2.432SCRIB, CCL2
cellular response to retinoic acid (GO:0071300) 5.522T, CCL2
response to lipid (GO:0033993) 3.112T, CCL2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462T, DACT1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62T, DACT1
regulation of programmed cell death (GO:0043067) 2.492CCL2, SCRIB
regulation of nervous system development (GO:0051960) 3.12VANGL2, CELSR1
regulation of gene expression (GO:0010468) 1.372T, DACT1
negative regulation of canonical Wnt signaling pathway (GO:0090090) 4.632FUZ, DACT1
negative regulation of mitotic cell cycle (GO:0045930) 4.452DACT1, SCRIB
response to retinoic acid (GO:0032526) 5.022T, CCL2
regulation of cell migration (GO:0030334) 3.232FUZ, CCL2
nonmotile primary cilium assembly (GO:0035058) 6.512VANGL2, FUZ
positive regulation of phosphate metabolic process (GO:0045937) 2.782VANGL2, CCL2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432T, DACT1
positive regulation of intracellular protein transport (GO:0090316) 4.192DACT1, CCL2
negative regulation of RNA biosynthetic process (GO:1902679) 2.72T, DACT1
reproductive process (GO:0022414) 2.552T, CCL2
biosynthetic process (GO:0009058) 1.322VANGL2, T
macromolecule biosynthetic process (GO:0009059) 1.612VANGL2, T
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis (GO:0060488) 9.042VANGL2, CELSR1
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis (GO:0060489) 9.042VANGL2, CELSR1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472T, DACT1
response to chemical (GO:0042221) 1.982T, CCL2
Ras protein signal transduction (GO:0007265) 4.762VANGL2, CELSR1
small GTPase mediated signal transduction (GO:0007264) 3.852VANGL2, CELSR1
glial cell migration (GO:0008347) 6.682SCRIB, CCL2
response to oxygen-containing compound (GO:1901700) 2.572T, CCL2
primary metabolic process (GO:0044238) 0.692T, CCL2
negative regulation of cellular component movement (GO:0051271) 4.222FUZ, CCL2
regulation of cellular component movement (GO:0051270) 3.082FUZ, CCL2
regulation of cell cycle (GO:0051726) 2.932DACT1, SCRIB
regulation of cellular component biogenesis (GO:0044087) 3.082FUZ, DACT1
single-organism organelle organization (GO:1902589) 2.682VANGL2, FUZ
(GO:1905276) 6.782VANGL2, CELSR1
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152CCL2, SCRIB
positive regulation of protein phosphorylation (GO:0001934) 2.952VANGL2, CCL2

NET-GE enrichment

Term New enriched termICP valueGenes
developmental process (GO:0032502) -1.360.009VANGL2, DACT1, SCRIB, CELSR1, CCL2, FUZ, T, VANGL1
asymmetric protein localization (GO:0008105) -6.840.0VANGL2, CELSR1, SCRIB
Wnt signaling pathway (GO:0016055) -3.880.005CELSR1, VANGL2, T, DACT1, SCRIB
establishment or maintenance of bipolar cell polarity (GO:0061245) -6.150.035VANGL2, SCRIB
dichotomous subdivision of an epithelial terminal unit (GO:0060600) -7.430.008VANGL2, CELSR1
convergent extension involved in axis elongation (GO:0060028) NEW7.940.008VANGL2, DACT1
convergent extension involved in organogenesis (GO:0060029) NEW8.120.005VANGL2, DACT1
cell projection organization (GO:0030030) -3.140.049DACT1, FUZ, VANGL2, SCRIB
tube formation (GO:0035148) -4.980.0CELSR1, VANGL2, T, FUZ, SCRIB
regulation of Wnt signaling pathway (GO:0030111) -3.980.005DACT1, FUZ, T, VANGL2, SCRIB
lateral sprouting involved in lung morphogenesis (GO:0060490) -9.040.002VANGL2, CELSR1
establishment of tissue polarity (GO:0007164) -6.840.0CELSR1, VANGL2, FUZ, DACT1
establishment of body hair planar orientation (GO:0048105) -9.040.002VANGL2, CELSR1
establishment of body hair or bristle planar orientation (GO:0048104) -9.040.002VANGL2, CELSR1
epidermis development (GO:0008544) NEW5.040.011CELSR1, VANGL2, FUZ
anatomical structure morphogenesis (GO:0009653) -2.530.0DACT1, CELSR1, SCRIB, VANGL2, CCL2, FUZ, T
negative regulation of Wnt signaling pathway (GO:0030178) -4.440.013FUZ, T, DACT1, SCRIB
regionalization (GO:0003002) -4.240.002CELSR1, VANGL2, T, FUZ, DACT1
morphogenesis of an epithelium (GO:0002009) -4.080.001SCRIB, DACT1, VANGL2, CCL2, CELSR1, T
establishment or maintenance of apical/basal cell polarity (GO:0035088) -6.150.035VANGL2, SCRIB
apical protein localization (GO:0045176) -7.240.038VANGL2, CELSR1
hair follicle development (GO:0001942) -6.020.0CELSR1, VANGL2, FUZ
response to wounding (GO:0009611) -4.390.002DACT1, VANGL2, CELSR1, CCL2, SCRIB
post-anal tail morphogenesis (GO:0036342) -6.840.022VANGL2, T, DACT1
glial cell migration (GO:0008347) -6.680.016SCRIB, CCL2
tissue morphogenesis (GO:0048729) -3.870.007SCRIB, DACT1, VANGL2, CCL2, CELSR1, T
dichotomous subdivision of terminal units involved in lung branching (GO:0060448) -8.630.0VANGL2, CELSR1, DACT1
positive regulation of apoptotic cell clearance (GO:2000427) NEW7.780.019T, CCL2
neural tube closure (GO:0001843) -5.380.0CELSR1, VANGL2, T, FUZ, SCRIB
anatomical structure formation involved in morphogenesis (GO:0048646) -3.010.008DACT1, CELSR1, SCRIB, VANGL2, CCL2, FUZ, T
embryonic morphogenesis (GO:0048598) -3.720.0CELSR1, FUZ, T, VANGL2, DACT1
organ morphogenesis (GO:0009887) -3.550.011VANGL2, T, FUZ, CCL2
nonmotile primary cilium assembly (GO:0035058) -6.510.014VANGL2, FUZ
pattern specification process (GO:0007389) -3.790.009CELSR1, VANGL2, T, FUZ
epithelium development (GO:0060429) NEW4.570.017CELSR1, VANGL2, T, FUZ, DACT1
wound healing (GO:0042060) -5.130.001CELSR1, VANGL2, SCRIB, CCL2
membranous septum morphogenesis (GO:0003149) NEW7.940.014VANGL2, DACT1
tube closure (GO:0060606) -5.360.0CELSR1, VANGL2, T, FUZ, SCRIB
inner ear receptor stereocilium organization (GO:0060122) -6.470.02VANGL2, SCRIB
astrocyte cell migration (GO:0043615) -7.940.002SCRIB, CCL2
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis (GO:0060488) -9.040.002VANGL2, CELSR1
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis (GO:0060489) -9.040.002VANGL2, CELSR1
regulation of embryonic development (GO:0045995) -4.980.006CELSR1, VANGL2, FUZ
lateral sprouting from an epithelium (GO:0060601) -7.650.003VANGL2, CELSR1
establishment of planar polarity (GO:0001736) -6.90.0CELSR1, FUZ, VANGL2, DACT1
non-canonical Wnt signaling pathway (GO:0035567) -4.790.044VANGL2, CELSR1, DACT1
single-organism developmental process (GO:0044767) -1.490.004VANGL2, DACT1, SCRIB, CELSR1, CCL2, FUZ, T, VANGL1
establishment of planar polarity of embryonic epithelium (GO:0042249) -8.120.001VANGL2, CELSR1, DACT1
anterior/posterior pattern specification (GO:0009952) -4.710.02VANGL2, T, CELSR1, DACT1
regulation of establishment of planar polarity (GO:0090175) -5.020.027VANGL2, CELSR1
planar cell polarity pathway involved in neural tube closure (GO:0090179) -7.160.0VANGL2, CELSR1, DACT1
regulation of establishment of planar polarity involved in neural tube closure (GO:0090178) -7.020.011VANGL2, CELSR1, DACT1
molting cycle process (GO:0022404) -5.540.002CELSR1, VANGL2, T, FUZ
hair cycle process (GO:0022405) -5.540.002CELSR1, VANGL2, T, FUZ
regulation of organ morphogenesis (GO:2000027) -4.220.042VANGL2, T, CELSR1, DACT1
Wnt signaling pathway, planar cell polarity pathway (GO:0060071) -5.120.024VANGL2, CELSR1
regulation of canonical Wnt signaling pathway (GO:0060828) -4.260.035FUZ, T, DACT1, SCRIB
convergent extension involved in neural plate elongation (GO:0022007) NEW8.630.001VANGL2, DACT1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.118VANGL2, DACT1, SCRIB, CELSR1, CCL2, FUZ, T, VANGL1
intracellular part (GO:0044424) 0.287DACT1, CELSR1, SCRIB, VANGL2, CCL2, FUZ, T
membrane-bounded organelle (GO:0043227) 0.476SCRIB, DACT1, VANGL2, CCL2, FUZ, T
organelle (GO:0043226) 0.46SCRIB, DACT1, VANGL2, CCL2, FUZ, T
intracellular organelle part (GO:0044446) 0.815CELSR1, VANGL2, T, DACT1, SCRIB
cytoplasm (GO:0005737) 1.015DACT1, FUZ, T, SCRIB, CCL2
intracellular organelle (GO:0043229) 0.515VANGL2, T, DACT1, CCL2, FUZ
organelle part (GO:0044422) 0.795CELSR1, VANGL2, T, DACT1, SCRIB
intracellular membrane-bounded organelle (GO:0043231) 0.64VANGL2, T, DACT1, CCL2
membrane (GO:0016020) 0.684CELSR1, VANGL2, VANGL1, SCRIB
membrane-bounded vesicle (GO:0031988) 1.714VANGL2, SCRIB, CCL2, FUZ
cytoplasmic part (GO:0044444) 0.824DACT1, VANGL2, CCL2, SCRIB
nuclear part (GO:0044428) 1.554CELSR1, T, DACT1, SCRIB
plasma membrane (GO:0005886) 1.394CELSR1, VANGL2, VANGL1, SCRIB
membrane part (GO:0044425) 0.954CELSR1, VANGL2, VANGL1, SCRIB
plasma membrane part (GO:0044459) 1.954CELSR1, VANGL2, VANGL1, SCRIB
vesicle (GO:0031982) 1.644VANGL2, SCRIB, CCL2, FUZ
macromolecular complex (GO:0032991) 1.353T, DACT1, SCRIB
integral component of membrane (GO:0016021) 1.143VANGL2, CELSR1, VANGL1
nucleoplasm (GO:0005654) 1.893CELSR1, DACT1, SCRIB
intrinsic component of membrane (GO:0031224) 1.133VANGL2, CELSR1, VANGL1
extracellular region part (GO:0044421) 1.573FUZ, CCL2, SCRIB
cell junction (GO:0030054) 2.753VANGL2, DACT1, SCRIB
protein complex (GO:0043234) 1.512DACT1, SCRIB
plasma membrane region (GO:0098590) 2.972VANGL2, SCRIB
extracellular vesicle (GO:1903561) 1.892FUZ, SCRIB
extracellular organelle (GO:0043230) 1.892FUZ, SCRIB
extracellular exosome (GO:0070062) 1.892FUZ, SCRIB
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122VANGL2, CCL2
cytoplasmic vesicle (GO:0031410) 2.872VANGL2, CCL2
cytosol (GO:0005829) 1.682DACT1, SCRIB
basolateral plasma membrane (GO:0016323) 4.562VANGL2, SCRIB
neuron part (GO:0097458) 2.642SCRIB, CCL2
intracellular vesicle (GO:0097708) 2.862VANGL2, CCL2
cell-cell junction (GO:0005911) 3.852VANGL2, SCRIB
lateral plasma membrane (GO:0016328) 5.892VANGL2, VANGL1
cell projection (GO:0042995) 2.472CCL2, SCRIB
nucleus (GO:0005634) 1.072T, DACT1
synapse (GO:0045202) 3.582DACT1, CCL2

NET-GE enrichment

Term New enriched termICP valueGenes
lateral plasma membrane (GO:0016328) -5.890.008VANGL2, VANGL1
cell pole (GO:0060187) NEW9.110.003VANGL2, DACT1