Disease table of PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA OMIM ID: 606864

Gene-disease associations table

GeneAssociated with PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SDHCOMIMHGNC link1q23.34604287, 606864, PS168000, 606764
SDHBOMIMHGNC link1p36.136171300, 604287, 606764, 606864, PS168000, PS158350
SDHDOMIMHGNC link11q23.16252011, PS168000, 606864, 114900, 171300, PS158350

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
12SDHB, SDHC
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SDHBYES4NRF1, NFE2L2, PLAGL1, HIF1A0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SDHCSDHBYes2MTCH2, SDHA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SDHCSDHBYesbinding3UBC, SDHD, SDHA
SDHCSDHDYesbinding3CYC1, SDHB, SDHA
SDHBSDHDYesbinding2SDHC, SDHA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
SDHBSDHCyes, complexComponents of complex composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
SDHBSDHDyes, complexComponents of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
SDHCSDHDyes, complexComponents of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Oxidative phosphorylationhsa001905.693SDHC, SDHD, SDHB
Metabolic pathwayshsa011002.493SDHC, SDHD, SDHB
Carbon metabolismhsa012006.033SDHC, SDHD, SDHB
Citrate cycle (TCA cycle)hsa000207.863SDHC, SDHD, SDHB
Non-alcoholic fatty liver disease (NAFLD)hsa049325.513SDHC, SDHD, SDHB
Huntington's diseasehsa050165.173SDHC, SDHD, SDHB
Alzheimer's diseasehsa050105.343SDHC, SDHD, SDHB
Parkinson's diseasehsa050125.593SDHC, SDHD, SDHB

NET-GE enrichment

Term New enriched termICP valueGenes
Neurodegenerative diseasesNEW4.270.002SDHC, SDHD, SDHB
Endocrine and metabolic diseasesNEW4.750.005SDHC, SDHD, SDHB
Oxidative phosphorylation (hsa00190) -5.690.0SDHC, SDHD, SDHB
Parkinson's disease (hsa05012) -5.590.0SDHC, SDHD, SDHB
Energy metabolismNEW5.420.0SDHC, SDHD, SDHB
Carbohydrate metabolismNEW4.360.002SDHC, SDHD, SDHB
Carbon metabolism (hsa01200) -6.030.0SDHC, SDHD, SDHB
Non-alcoholic fatty liver disease (NAFLD) (hsa04932) -5.510.0SDHC, SDHD, SDHB
Huntington's disease (hsa05016) -5.170.001SDHC, SDHD, SDHB
Alzheimer's disease (hsa05010) -5.340.0SDHC, SDHD, SDHB
Citrate cycle (TCA cycle) (hsa00020) -7.860.0SDHC, SDHD, SDHB
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Respiratory electron transportR-HSA-6111056.443SDHC, SDHD, SDHB
Pyruvate metabolism and Citric Acid (TCA) cycleR-HSA-714067.563SDHC, SDHD, SDHB
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-1632006.123SDHC, SDHD, SDHB
Citric acid cycle (TCA cycle)R-HSA-714038.733SDHC, SDHD, SDHB
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.713SDHC, SDHD, SDHB
MetabolismR-HSA-14307282.343SDHC, SDHD, SDHB

NET-GE enrichment

Term New enriched termICP valueGenes
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517) -5.710.0SDHC, SDHD, SDHB
Respiratory electron transport (R-HSA-611105) -6.440.0SDHC, SDHD, SDHB
Pyruvate metabolism and Citric Acid (TCA) cycle (R-HSA-71406) -7.560.0SDHC, SDHD, SDHB
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200) -6.120.0SDHC, SDHD, SDHB
Citric acid cycle (TCA cycle) (R-HSA-71403) -8.730.0SDHC, SDHD, SDHB
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cation binding (GO:0043169) 1.43SDHC, SDHD, SDHB
metal ion binding (GO:0046872) 1.413SDHC, SDHD, SDHB
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) 5.663SDHC, SDHD, SDHB
ion binding (GO:0043167) 1.363SDHC, SDHD, SDHB
catalytic activity (GO:0003824) 1.053SDHC, SDHD, SDHB
binding (GO:0005488) 0.183SDHC, SDHD, SDHB
electron carrier activity (GO:0009055) 4.973SDHC, SDHD, SDHB
succinate dehydrogenase activity (GO:0000104) 8.133SDHC, SDHD, SDHB
oxidoreductase activity (GO:0016491) 3.123SDHC, SDHD, SDHB
heme binding (GO:0020037) 4.862SDHC, SDHD
tetrapyrrole binding (GO:0046906) 4.82SDHC, SDHD
organic cyclic compound binding (GO:0097159) 1.052SDHC, SDHD
cofactor binding (GO:0048037) 4.162SDHD, SDHB
ubiquinone binding (GO:0048039) 8.352SDHD, SDHB
quinone binding (GO:0048038) 6.912SDHD, SDHB
heterocyclic compound binding (GO:1901363) 1.062SDHC, SDHD

NET-GE enrichment

Term New enriched termICP valueGenes
oxidoreductase activity (GO:0016491) -3.120.039SDHC, SDHD, SDHB
succinate dehydrogenase activity (GO:0000104) -8.130.0SDHC, SDHD, SDHB
heme binding (GO:0020037) -4.860.028SDHC, SDHD
tetrapyrrole binding (GO:0046906) -4.80.033SDHC, SDHD
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) -5.660.0SDHC, SDHD, SDHB
cofactor binding (GO:0048037) -4.160.02SDHD, SDHB
ubiquinone binding (GO:0048039) -8.350.0SDHD, SDHB
quinone binding (GO:0048038) -6.910.0SDHD, SDHB
electron carrier activity (GO:0009055) -4.970.0SDHC, SDHD, SDHB
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
primary metabolic process (GO:0044238) 0.693SDHC, SDHD, SDHB
single-organism metabolic process (GO:0044710) 1.633SDHC, SDHD, SDHB
organic acid metabolic process (GO:0006082) 3.013SDHC, SDHD, SDHB
cellular process (GO:0009987) 0.263SDHC, SDHD, SDHB
oxidation-reduction process (GO:0055114) 2.913SDHC, SDHD, SDHB
cellular metabolic process (GO:0044237) 0.693SDHC, SDHD, SDHB
organic substance metabolic process (GO:0071704) 0.633SDHC, SDHD, SDHB
tricarboxylic acid cycle (GO:0006099) 6.333SDHC, SDHD, SDHB
single-organism cellular process (GO:0044763) 0.653SDHC, SDHD, SDHB
small molecule metabolic process (GO:0044281) 2.383SDHC, SDHD, SDHB
metabolic process (GO:0008152) 0.583SDHC, SDHD, SDHB
single-organism process (GO:0044699) 0.483SDHC, SDHD, SDHB
aerobic respiration (GO:0009060) 6.42SDHC, SDHB
energy derivation by oxidation of organic compounds (GO:0015980) 4.932SDHC, SDHB
electron transport chain (GO:0022900) 5.092SDHC, SDHB
cellular respiration (GO:0045333) 5.92SDHC, SDHB
respiratory electron transport chain (GO:0022904) 5.112SDHC, SDHB
generation of precursor metabolites and energy (GO:0006091) 4.072SDHC, SDHB

NET-GE enrichment

Term New enriched termICP valueGenes
aerobic respiration (GO:0009060) -6.40.0SDHC, SDHB
energy derivation by oxidation of organic compounds (GO:0015980) -4.930.008SDHC, SDHB
tricarboxylic acid cycle (GO:0006099) -6.330.0SDHC, SDHD, SDHB
electron transport chain (GO:0022900) -5.090.0SDHC, SDHD, SDHB
cellular respiration (GO:0045333) -5.90.001SDHC, SDHB
respiratory electron transport chain (GO:0022904) -5.110.0SDHC, SDHD, SDHB
generation of precursor metabolites and energy (GO:0006091) -4.070.0SDHC, SDHD, SDHB
oxidation-reduction process (GO:0055114) -2.910.004SDHC, SDHD, SDHB
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
respiratory chain complex (GO:0098803) 5.473SDHC, SDHD, SDHB
oxidoreductase complex (GO:1990204) 5.193SDHC, SDHD, SDHB
intracellular organelle (GO:0043229) 0.513SDHC, SDHD, SDHB
mitochondrion (GO:0005739) 2.423SDHC, SDHD, SDHB
membrane-bounded organelle (GO:0043227) 0.473SDHC, SDHD, SDHB
organelle (GO:0043226) 0.43SDHC, SDHD, SDHB
organelle membrane (GO:0031090) 1.973SDHC, SDHD, SDHB
membrane protein complex (GO:0098796) 2.843SDHC, SDHD, SDHB
membrane (GO:0016020) 0.683SDHC, SDHD, SDHB
fumarate reductase complex (GO:0045283) 8.423SDHC, SDHD, SDHB
succinate dehydrogenase complex (GO:0045281) 8.423SDHC, SDHD, SDHB
inner mitochondrial membrane protein complex (GO:0098800) 5.013SDHC, SDHD, SDHB
mitochondrial membrane part (GO:0044455) 4.543SDHC, SDHD, SDHB
cell part (GO:0044464) 0.113SDHC, SDHD, SDHB
catalytic complex (GO:1902494) 2.93SDHC, SDHD, SDHB
mitochondrial membrane (GO:0031966) 3.313SDHC, SDHD, SDHB
protein complex (GO:0043234) 1.513SDHC, SDHD, SDHB
succinate dehydrogenase complex (ubiquinone) (GO:0045257) 8.423SDHC, SDHD, SDHB
macromolecular complex (GO:0032991) 1.353SDHC, SDHD, SDHB
intracellular membrane-bounded organelle (GO:0043231) 0.63SDHC, SDHD, SDHB
organelle inner membrane (GO:0019866) 3.563SDHC, SDHD, SDHB
intracellular organelle part (GO:0044446) 0.813SDHC, SDHD, SDHB
mitochondrial inner membrane (GO:0005743) 3.653SDHC, SDHD, SDHB
cytoplasmic part (GO:0044444) 0.823SDHC, SDHD, SDHB
mitochondrial part (GO:0044429) 2.923SDHC, SDHD, SDHB
intracellular part (GO:0044424) 0.283SDHC, SDHD, SDHB
membrane part (GO:0044425) 0.953SDHC, SDHD, SDHB
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) (GO:0005749) 8.423SDHC, SDHD, SDHB
organelle part (GO:0044422) 0.793SDHC, SDHD, SDHB
mitochondrial protein complex (GO:0098798) 4.783SDHC, SDHD, SDHB
respiratory chain complex II (GO:0045273) 9.112SDHC, SDHB
integral component of membrane (GO:0016021) 1.142SDHC, SDHD
intrinsic component of membrane (GO:0031224) 1.132SDHC, SDHD

NET-GE enrichment

Term New enriched termICP valueGenes
mitochondrial membrane part (GO:0044455) -4.540.0SDHC, SDHD, SDHB
succinate dehydrogenase complex (ubiquinone) (GO:0045257) -8.420.0SDHC, SDHD, SDHB
catalytic complex (GO:1902494) -2.90.003SDHC, SDHD, SDHB
fumarate reductase complex (GO:0045283) -8.420.0SDHC, SDHD, SDHB
organelle inner membrane (GO:0019866) -3.560.002SDHC, SDHD, SDHB
succinate dehydrogenase complex (GO:0045281) -8.420.0SDHC, SDHD, SDHB
oxidoreductase complex (GO:1990204) -5.190.0SDHC, SDHD, SDHB
mitochondrial respiratory chain complex II (GO:0005749) -8.420.0SDHC, SDHD, SDHB
mitochondrial inner membrane (GO:0005743) -3.650.0SDHC, SDHD, SDHB
mitochondrion (GO:0005739) -2.420.011SDHC, SDHD, SDHB
mitochondrial part (GO:0044429) -2.920.03SDHC, SDHD, SDHB
mitochondrial membrane (GO:0031966) -3.310.006SDHC, SDHD, SDHB