Disease table of PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA OMIM ID: 606864

Gene-disease associations table

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Gene	Associated with PARAGANGLIOMA AND GASTRIC STROMAL SARCOMA in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
SDHB	OMIM	HGNC link	1p36.13	6	171300, 604287, 606764, 606864, PS168000, PS158350
SDHC	OMIM	HGNC link	1q23.3	4	604287, 606864, PS168000, 606764
SDHD	OMIM	HGNC link	11q23.1	6	252011, PS168000, 606864, 114900, 171300, PS158350

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Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
1	2	SDHB, SDHC

Transcription Factors (TF) annotation from TRRUST

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regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
SDHB	YES	4	NRF1, NFE2L2, PLAGL1, HIF1A	0

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Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
SDHC	SDHB	Yes	2	MTCH2, SDHA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

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Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
SDHC	SDHB	Yes	binding	3	UBC, SDHD, SDHA
SDHC	SDHD	Yes	binding	3	CYC1, SDHB, SDHA
SDHB	SDHD	Yes	binding	2	SDHC, SDHA

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Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

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Gene1	Gene2	Direct interaction	More information
SDHB	SDHC	yes, complex	Components of complex composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
SDHB	SDHD	yes, complex	Components of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
SDHC	SDHD	yes, complex	Components of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]

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KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

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KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Citrate cycle (TCA cycle)	hsa00020	7.86	3	SDHC, SDHD, SDHB
Carbon metabolism	hsa01200	6.03	3	SDHC, SDHD, SDHB
Oxidative phosphorylation	hsa00190	5.69	3	SDHC, SDHD, SDHB
Parkinson's disease	hsa05012	5.59	3	SDHC, SDHD, SDHB
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51	3	SDHC, SDHD, SDHB
Alzheimer's disease	hsa05010	5.34	3	SDHC, SDHD, SDHB
Huntington's disease	hsa05016	5.17	3	SDHC, SDHD, SDHB
Metabolic pathways	hsa01100	2.49	3	SDHC, SDHD, SDHB

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
Citrate cycle (TCA cycle) (hsa00020)	-	7.86	0.0	SDHC, SDHD, SDHB
Carbon metabolism (hsa01200)	-	6.03	0.0	SDHC, SDHD, SDHB
Oxidative phosphorylation (hsa00190)	-	5.69	0.0	SDHC, SDHD, SDHB
Parkinson's disease (hsa05012)	-	5.59	0.0	SDHC, SDHD, SDHB
Non-alcoholic fatty liver disease (NAFLD) (hsa04932)	-	5.51	0.0	SDHC, SDHD, SDHB
Energy metabolism	NEW	5.42	0.0	SDHC, SDHD, SDHB
Alzheimer's disease (hsa05010)	-	5.34	0.0	SDHC, SDHD, SDHB
Huntington's disease (hsa05016)	-	5.17	0.001	SDHC, SDHD, SDHB
Endocrine and metabolic diseases	NEW	4.75	0.005	SDHC, SDHD, SDHB
Carbohydrate metabolism	NEW	4.36	0.002	SDHC, SDHD, SDHB

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REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

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REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Citric acid cycle (TCA cycle)	R-HSA-71403	8.73	3	SDHC, SDHD, SDHB
Pyruvate metabolism and Citric Acid (TCA) cycle	R-HSA-71406	7.56	3	SDHC, SDHD, SDHB
Respiratory electron transport	R-HSA-611105	6.44	3	SDHC, SDHD, SDHB
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	R-HSA-163200	6.12	3	SDHC, SDHD, SDHB
The citric acid (TCA) cycle and respiratory electron transport	R-HSA-1428517	5.71	3	SDHC, SDHD, SDHB
Metabolism	R-HSA-1430728	2.34	3	SDHC, SDHD, SDHB

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NET-GE enrichment

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Term	New enriched term	IC	Genes
Citric acid cycle (TCA cycle) (R-HSA-71403)	-	8.73	SDHC, SDHD, SDHB
Pyruvate metabolism and Citric Acid (TCA) cycle (R-HSA-71406)	-	7.56	SDHC, SDHD, SDHB
Respiratory electron transport (R-HSA-611105)	-	6.44	SDHC, SDHD, SDHB
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200)	-	6.12	SDHC, SDHD, SDHB
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517)	-	5.71	SDHC, SDHD, SDHB

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GO - molecular function annotation: shared terms / NET-GE enrichment

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GO	IC	Number of genes with the same GO	Genes
ubiquinone binding (GO:0048039)	8.35	2	SDHD, SDHB
succinate dehydrogenase activity (GO:0000104)	8.13	3	SDHC, SDHD, SDHB
quinone binding (GO:0048038)	6.91	2	SDHD, SDHB
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627)	5.66	3	SDHC, SDHD, SDHB
electron carrier activity (GO:0009055)	4.97	3	SDHC, SDHD, SDHB
heme binding (GO:0020037)	4.86	2	SDHC, SDHD
tetrapyrrole binding (GO:0046906)	4.8	2	SDHC, SDHD
cofactor binding (GO:0048037)	4.16	2	SDHD, SDHB
oxidoreductase activity (GO:0016491)	3.12	3	SDHC, SDHD, SDHB
metal ion binding (GO:0046872)	1.41	3	SDHC, SDHD, SDHB

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
ubiquinone binding (GO:0048039)	-	8.35	0.0	SDHD, SDHB
succinate dehydrogenase activity (GO:0000104)	-	8.13	0.0	SDHC, SDHD, SDHB
quinone binding (GO:0048038)	-	6.91	0.0	SDHD, SDHB
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627)	-	5.66	0.0	SDHC, SDHD, SDHB
electron carrier activity (GO:0009055)	-	4.97	0.0	SDHC, SDHD, SDHB
heme binding (GO:0020037)	-	4.86	0.028	SDHC, SDHD
tetrapyrrole binding (GO:0046906)	-	4.8	0.033	SDHC, SDHD
cofactor binding (GO:0048037)	-	4.16	0.02	SDHD, SDHB
oxidoreductase activity (GO:0016491)	-	3.12	0.039	SDHC, SDHD, SDHB

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GO - biological process annotation: shared terms / NET-GE enrichment

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GO	IC	Number of genes with the same GO	Genes
aerobic respiration (GO:0009060)	6.4	2	SDHC, SDHB
tricarboxylic acid cycle (GO:0006099)	6.33	3	SDHC, SDHD, SDHB
cellular respiration (GO:0045333)	5.9	2	SDHC, SDHB
respiratory electron transport chain (GO:0022904)	5.11	2	SDHC, SDHB
electron transport chain (GO:0022900)	5.09	2	SDHC, SDHB
energy derivation by oxidation of organic compounds (GO:0015980)	4.93	2	SDHC, SDHB
generation of precursor metabolites and energy (GO:0006091)	4.07	2	SDHC, SDHB
organic acid metabolic process (GO:0006082)	3.01	3	SDHC, SDHD, SDHB
oxidation-reduction process (GO:0055114)	2.91	3	SDHC, SDHD, SDHB
small molecule metabolic process (GO:0044281)	2.38	3	SDHC, SDHD, SDHB

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
aerobic respiration (GO:0009060)	-	6.4	0.0	SDHC, SDHB
tricarboxylic acid cycle (GO:0006099)	-	6.33	0.0	SDHC, SDHD, SDHB
cellular respiration (GO:0045333)	-	5.9	0.001	SDHC, SDHB
respiratory electron transport chain (GO:0022904)	-	5.11	0.0	SDHC, SDHD, SDHB
electron transport chain (GO:0022900)	-	5.09	0.0	SDHC, SDHD, SDHB
energy derivation by oxidation of organic compounds (GO:0015980)	-	4.93	0.008	SDHC, SDHB
generation of precursor metabolites and energy (GO:0006091)	-	4.07	0.0	SDHC, SDHD, SDHB
oxidation-reduction process (GO:0055114)	-	2.91	0.004	SDHC, SDHD, SDHB

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GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

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GO	IC	Number of genes with the same GO	Genes
respiratory chain complex II (GO:0045273)	9.11	2	SDHC, SDHB
fumarate reductase complex (GO:0045283)	8.42	3	SDHC, SDHD, SDHB
succinate dehydrogenase complex (GO:0045281)	8.42	3	SDHC, SDHD, SDHB
succinate dehydrogenase complex (ubiquinone) (GO:0045257)	8.42	3	SDHC, SDHD, SDHB
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) (GO:0005749)	8.42	3	SDHC, SDHD, SDHB
respiratory chain complex (GO:0098803)	5.47	3	SDHC, SDHD, SDHB
oxidoreductase complex (GO:1990204)	5.19	3	SDHC, SDHD, SDHB
inner mitochondrial membrane protein complex (GO:0098800)	5.01	3	SDHC, SDHD, SDHB
mitochondrial protein complex (GO:0098798)	4.78	3	SDHC, SDHD, SDHB
mitochondrial membrane part (GO:0044455)	4.54	3	SDHC, SDHD, SDHB

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
succinate dehydrogenase complex (ubiquinone) (GO:0045257)	-	8.42	0.0	SDHC, SDHD, SDHB
fumarate reductase complex (GO:0045283)	-	8.42	0.0	SDHC, SDHD, SDHB
succinate dehydrogenase complex (GO:0045281)	-	8.42	0.0	SDHC, SDHD, SDHB
mitochondrial respiratory chain complex II (GO:0005749)	-	8.42	0.0	SDHC, SDHD, SDHB
oxidoreductase complex (GO:1990204)	-	5.19	0.0	SDHC, SDHD, SDHB
mitochondrial membrane part (GO:0044455)	-	4.54	0.0	SDHC, SDHD, SDHB
mitochondrial inner membrane (GO:0005743)	-	3.65	0.0	SDHC, SDHD, SDHB
organelle inner membrane (GO:0019866)	-	3.56	0.002	SDHC, SDHD, SDHB
mitochondrial membrane (GO:0031966)	-	3.31	0.006	SDHC, SDHD, SDHB
mitochondrial part (GO:0044429)	-	2.92	0.03	SDHC, SDHD, SDHB

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