Disease table of GASTROINTESTINAL STROMAL TUMOR OMIM ID: 606764

Gene-disease associations table

Gene	Associated with GASTROINTESTINAL STROMAL TUMOR in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
PDGFRA	ClinVar, OMIM, HUMSAVAR	HGNC link	4q12	3	119540, 606764, 607685
MTHFR	ClinVar	HGNC link	1p36.22	5	181500, PS188050, 606764, 236250, 601634
KIT	ClinVar, OMIM, HUMSAVAR	HGNC link	4q12	5	601626, 172800, 273300, 606764, 154800
MTR	ClinVar	HGNC link	1q43	3	601634, 250940, 606764
MTRR	ClinVar	HGNC link	5p15.31	3	601634, 236270, 606764
SDHC	ClinVar, OMIM	HGNC link	1q23.3	4	604287, 606864, PS168000, 606764
SDHB	ClinVar, OMIM	HGNC link	1p36.13	6	171300, 604287, 606764, 606864, PS168000, PS158350
FOLR1	ClinVar	HGNC link	11q13.4	2	613068, 606764
SHMT1	ClinVar	HGNC link	17p11.2	1	606764
SLC19A1	ClinVar	HGNC link	21q22.3	1	606764

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Common tandem group	Number of genes in this tandem group associated to this disease	Genes in this tandem group associated to this disease
Group 212	2	KIT, PDGFRA

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
4q12	2	KIT, PDGFRA

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
4q12	2	KIT, PDGFRA
1p36	2	SDHB, MTHFR

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
4q1	2	KIT, PDGFRA
1p3	2	SDHB, MTHFR

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1q	2	MTR, SDHC
1p	2	SDHB, MTHFR
4q	2	KIT, PDGFRA

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
1	4	MTR, SDHC, MTHFR, SDHB
4	2	KIT, PDGFRA

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
NFE2L2	NO	17	SDHB, GSTA1, MTHFR, SOD1, GSS, CFTR, HBB, GCLC, NQO1, CAT, HMOX1, KRT16, CXCL8, BRCA1, MGST1, UGT2B7, SOD2	2	SDHB, MTHFR
TFAP2A	NO	69	SLC19A1, POLD2, L1CAM, MCAM, GALNT3, CRYAB, KISS1, CGB, EGFR, HTT, GAST, COL1A1, NME3, PTGS2, SPRY2, ACHE, MUC4, DBH, FOXA1, GUSB, DCBLD2, IGFBP5, CFTR, HSD17B1, ERBB2, ETS1, CD82, CYP11A1, PVR, ADM, KRT5, KIT, CCNB1, HGF, F2R, ECM1, APP, MPG, CRABP2, CDH1, PTEN, KLF12, VEGFA, GPX4, SULT1E1, CGA, LNPEP, TIMP2, MMP9, HOXA4, TAF7, NR3C1, BCL2, PLAUR, TH, ADRA2B, MMP2, CDKN1A, FAS, ADRA1A, IMPDH2, SNAP91, PRKCA, HMOX1, BACE1, CRX, BRS3, HIP1, CSH1	2	SLC19A1, KIT
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	3	SLC19A1, FOLR1, KIT

regulated gene	associated to this disease	# TFs	TFs
PDGFRA	YES	5	CEBPD, PAX1, SMAD4, GLI2, GLI1
MTHFR	YES	1	NFE2L2
KIT	YES	4	SP1, TFAP2A, MITF, RBMX
SDHB	YES	4	NRF1, NFE2L2, PLAGL1, HIF1A
FOLR1	YES	1	SP1
SHMT1	YES	1	MYC
SLC19A1	YES	7	SP1, CREB1, CEBPB, JUN, TFAP2A, USF1, USF2

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
PDGFRA	KIT	Yes	8	PLCG1, CRK, CBL, PIK3R1, CRKL, PDGFRA, GRB2, STAT1
PDGFRA	MTR	No	1	NTRK1
PDGFRA	SHMT1	No	3	SNX2, SNX6, STAT1
KIT	SHMT1	No	1	STAT1
MTR	MTRR	No	1	ELAVL1
SDHC	SDHB	Yes	2	MTCH2, SDHA
SDHB	FOLR1	No	1	CUL3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
PDGFRA	KIT	No	-	89	KITLG, SH3GLB1, SOS1, PDGFB, EFNA2, WWP1, PLCB3, SH3GL2, PDGFA, FGF7, PHLPP2, CBLB, FGF18, FGF17, CBL, INS, PIK3R1, FGF12, ITCH, RNF41, FGF1, FGF10, SMURF1, SH3KBP1, NEDD4L, EFNA4, PGF, FGF2, PHLPP1, EPN2, FGF23, EPS15, ANGPT4, SHC3, FGF9, FGF22, IGF1, PIK3CB, GRB2, PIK3R3, PLCB1, PIK3CD, FGF19, FGF21, SH3GLB2, NEDD4, EGF, VEGFC, PLCB2, PLCG1, PLCB4, FGF14, FIGF, PIK3R5, SHC2, HRAS, SH3GL3, FGF20, VEGFA, VEGFB, EFNA5, FGF5, EFNA1, PDGFC, PDGFD, MDM2, FGF6, FGF4, CBLC, PIK3CG, ANGPT2, CRKL, ANGPT1, CRK, PIK3CA, SHC4, SHC1, EPN1, FGF11, TRAF6, UBC, SRC, SH3GL1, CSF1, FGF13, FGF8, IRS1, HGF, EPN3
PDGFRA	MTR	No	-	1	UBC
PDGFRA	SDHC	No	-	1	UBC
PDGFRA	SDHB	No	-	1	UBC
PDGFRA	SHMT1	No	-	1	UBC
PDGFRA	SLC19A1	No	-	1	UBC
KIT	MTR	No	-	1	UBC
KIT	SDHC	No	-	1	UBC
KIT	SDHB	No	-	1	UBC
KIT	SHMT1	No	-	2	UBC, MYC
KIT	SLC19A1	No	-	1	UBC
MTR	MTRR	Yes	binding	0
MTR	SDHC	No	-	1	UBC
MTR	SDHB	No	-	1	UBC
MTR	SHMT1	No	-	1	UBC
MTR	SLC19A1	No	-	1	UBC
SDHC	SDHB	Yes	binding	3	UBC, SDHD, SDHA
SDHC	SHMT1	No	-	1	UBC
SDHC	SLC19A1	No	-	1	UBC
SDHB	SHMT1	No	-	1	UBC
SDHB	SLC19A1	No	-	1	UBC
SHMT1	SLC19A1	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
SDHB	SDHC	yes, complex	Components of complex composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Metabolic pathways	hsa01100	2.49	5	SHMT1, SDHB, MTR, SDHC, MTHFR
Carbon metabolism	hsa01200	6.03	4	SHMT1, SDHC, SDHB, MTHFR
Endocytosis	hsa04144	4.92	3	FOLR1, PDGFRA, KIT
One carbon pool by folate	hsa00670	8.52	3	MTR, SHMT1, MTHFR
Parkinson's disease	hsa05012	5.59	2	SDHC, SDHB
Oxidative phosphorylation	hsa00190	5.69	2	SDHC, SDHB
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51	2	SDHC, SDHB
Pathways in cancer	hsa05200	3.98	2	PDGFRA, KIT
Rap1 signaling pathway	hsa04015	4.97	2	PDGFRA, KIT
Ras signaling pathway	hsa04014	4.9	2	PDGFRA, KIT
Central carbon metabolism in cancer	hsa05230	6.7	2	PDGFRA, KIT
Cytokine-cytokine receptor interaction	hsa04060	4.67	2	PDGFRA, KIT
Biosynthesis of amino acids	hsa01230	6.58	2	MTR, SHMT1
Huntington's disease	hsa05016	5.17	2	SDHC, SDHB
Alzheimer's disease	hsa05010	5.34	2	SDHC, SDHB
Citrate cycle (TCA cycle)	hsa00020	7.86	2	SDHC, SDHB
PI3K-Akt signaling pathway	hsa04151	4.21	2	PDGFRA, KIT

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Carbon metabolism (hsa01200)	-	6.03	0.003	SHMT1, SDHC, SDHB, MTHFR
Citrate cycle (TCA cycle) (hsa00020)	-	7.86	0.039	SDHC, SDHB
One carbon pool by folate (hsa00670)	-	8.52	0.001	MTR, SHMT1, MTHFR

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Metabolism	R-HSA-1430728	2.34	7	SLC19A1, MTR, MTHFR, SDHC, SHMT1, MTRR, SDHB
Metabolism of vitamins and cofactors	R-HSA-196854	6.54	5	SLC19A1, MTR, MTRR, SHMT1, MTHFR
Metabolism of water-soluble vitamins and cofactors	R-HSA-196849	6.54	5	SLC19A1, MTR, MTRR, SHMT1, MTHFR
Disease	R-HSA-1643685	3.33	4	MTR, KIT, PDGFRA, MTRR
Metabolism of amino acids and derivatives	R-HSA-71291	5.4	3	MTR, MTRR, SHMT1
Metabolism of folate and pterines	R-HSA-196757	9.81	3	SLC19A1, SHMT1, MTHFR
Interleukin-2 signaling	R-HSA-451927	5.05	2	PDGFRA, KIT
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	2	PDGFRA, KIT
GAB1 signalosome	R-HSA-180292	6.31	2	PDGFRA, KIT
Developmental Biology	R-HSA-1266738	3.48	2	PDGFRA, KIT
Signaling by VEGF	R-HSA-194138	4.66	2	PDGFRA, KIT
FCERI mediated MAPK activation	R-HSA-2871796	4.32	2	PDGFRA, KIT
IRS-mediated signalling	R-HSA-112399	4.87	2	PDGFRA, KIT
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	2	PDGFRA, KIT
Pyruvate metabolism and Citric Acid (TCA) cycle	R-HSA-71406	7.56	2	SDHC, SDHB
Citric acid cycle (TCA cycle)	R-HSA-71403	8.73	2	SDHC, SDHB
Cobalamin (Cbl, vitamin B12) transport and metabolism	R-HSA-196741	8.73	2	MTR, MTRR
Signaling by EGFR	R-HSA-177929	4.59	2	PDGFRA, KIT
Methylation	R-HSA-156581	9.66	2	MTR, MTRR
Phase II conjugation	R-HSA-156580	6.52	2	MTR, MTRR
PI-3K cascade:FGFR3	R-HSA-5654710	6.37	2	PDGFRA, KIT
Defects in cobalamin (B12) metabolism	R-HSA-3296469	9.28	2	MTR, MTRR
DAP12 interactions	R-HSA-2172127	4.56	2	PDGFRA, KIT
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	2	PDGFRA, KIT
Signaling by ERBB2	R-HSA-1227986	4.66	2	PDGFRA, KIT
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	2	PDGFRA, KIT
PI3K/AKT activation	R-HSA-198203	6.32	2	PDGFRA, KIT
Immune System	R-HSA-168256	2.37	2	PDGFRA, KIT
Frs2-mediated activation	R-HSA-170968	5.12	2	PDGFRA, KIT
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37	2	PDGFRA, KIT
Downstream signal transduction	R-HSA-186763	4.65	2	PDGFRA, KIT
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE	R-HSA-3359467	11.98	2	MTR, MTRR
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	R-HSA-3359469	11.98	2	MTR, MTRR
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95	2	PDGFRA, KIT
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	2	PDGFRA, KIT
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	2	PDGFRA, KIT
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	2	PDGFRA, KIT
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	2	PDGFRA, KIT
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	2	PDGFRA, KIT
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	2	PDGFRA, KIT
Interleukin receptor SHC signaling	R-HSA-912526	5.09	2	PDGFRA, KIT
Innate Immune System	R-HSA-168249	3.17	2	PDGFRA, KIT
Defects in vitamin and cofactor metabolism	R-HSA-3296482	8.52	2	MTR, MTRR
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	2	PDGFRA, KIT
Prolonged ERK activation events	R-HSA-169893	5.11	2	PDGFRA, KIT
Signaling by FGFR2	R-HSA-5654738	4.68	2	PDGFRA, KIT
GRB2 events in EGFR signaling	R-HSA-179812	5.15	2	PDGFRA, KIT
Signaling by FGFR1	R-HSA-5654736	4.69	2	PDGFRA, KIT
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37	2	PDGFRA, KIT
Diseases of metabolism	R-HSA-5668914	6.57	2	MTR, MTRR
Axon guidance	R-HSA-422475	3.93	2	PDGFRA, KIT
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	2	PDGFRA, KIT
Biological oxidations	R-HSA-211859	5.55	2	MTR, MTRR
The citric acid (TCA) cycle and respiratory electron transport	R-HSA-1428517	5.71	2	SDHC, SDHB
Signaling by Leptin	R-HSA-2586552	5.1	2	PDGFRA, KIT
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.05	2	PDGFRA, KIT
IGF1R signaling cascade	R-HSA-2428924	4.85	2	PDGFRA, KIT
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	2	PDGFRA, KIT
Signaling by Insulin receptor	R-HSA-74752	4.73	2	PDGFRA, KIT
Insulin receptor signalling cascade	R-HSA-74751	4.85	2	PDGFRA, KIT
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	2	PDGFRA, KIT
PI-3K cascade:FGFR4	R-HSA-5654720	6.37	2	PDGFRA, KIT
PI-3K cascade:FGFR1	R-HSA-5654689	6.37	2	PDGFRA, KIT
Sulfur amino acid metabolism	R-HSA-1614635	8.46	2	MTR, MTRR
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	2	PDGFRA, KIT
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56	2	PDGFRA, KIT
Diseases of signal transduction	R-HSA-5663202	4.89	2	PDGFRA, KIT
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	2	PDGFRA, KIT
Signalling to RAS	R-HSA-167044	5.08	2	PDGFRA, KIT
PI-3K cascade:FGFR2	R-HSA-5654695	6.37	2	PDGFRA, KIT
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	2	PDGFRA, KIT
SHC1 events in EGFR signaling	R-HSA-180336	5.15	2	PDGFRA, KIT
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	2	PDGFRA, KIT
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	2	PDGFRA, KIT
ARMS-mediated activation	R-HSA-170984	5.12	2	PDGFRA, KIT
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	2	PDGFRA, KIT
Signaling by PDGF	R-HSA-186797	4.53	2	PDGFRA, KIT
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	2	PDGFRA, KIT
Signaling by Interleukins	R-HSA-449147	4.71	2	PDGFRA, KIT
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	2	PDGFRA, KIT
SOS-mediated signalling	R-HSA-112412	5.15	2	PDGFRA, KIT
Signaling by ERBB4	R-HSA-1236394	4.7	2	PDGFRA, KIT
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	2	PDGFRA, KIT
Adaptive Immune System	R-HSA-1280218	3.19	2	PDGFRA, KIT
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	R-HSA-163200	6.12	2	SDHC, SDHB
MAPK family signaling cascades	R-HSA-5683057	4.89	2	PDGFRA, KIT
PIP3 activates AKT signaling	R-HSA-1257604	6.37	2	PDGFRA, KIT
RAF/MAP kinase cascade	R-HSA-5673001	5.15	2	PDGFRA, KIT
Signaling by FGFR4	R-HSA-5654743	4.69	2	PDGFRA, KIT
Signaling by FGFR3	R-HSA-5654741	4.69	2	PDGFRA, KIT
Respiratory electron transport	R-HSA-611105	6.44	2	SDHC, SDHB
Signaling by FGFR	R-HSA-190236	4.67	2	PDGFRA, KIT
Signaling by SCF-KIT	R-HSA-1433557	4.73	2	PDGFRA, KIT
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	PDGFRA, KIT
DAP12 signaling	R-HSA-2424491	4.64	2	PDGFRA, KIT
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	2	PDGFRA, KIT
Signalling by NGF	R-HSA-166520	4.23	2	PDGFRA, KIT
Signaling by GPCR	R-HSA-372790	2.68	2	PDGFRA, KIT
Signalling to ERKs	R-HSA-187687	5.04	2	PDGFRA, KIT
Signal Transduction	R-HSA-162582	1.78	2	PDGFRA, KIT

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Defects in vitamin and cofactor metabolism (R-HSA-3296482)	-	8.52	0.026	MTR, MTRR
Metabolism of folate and pterines (R-HSA-196757)	-	9.81	0.0	SLC19A1, SHMT1, MTHFR
Citric acid cycle (TCA cycle) (R-HSA-71403)	-	8.73	0.019	SDHC, SDHB
Metabolism of vitamins and cofactors (R-HSA-196854)	-	6.54	0.0	SLC19A1, SHMT1, MTR, MTRR, MTHFR
Sulfur amino acid metabolism (R-HSA-1614635)	-	8.46	0.028	MTR, MTRR
Methylation (R-HSA-156581)	-	9.66	0.008	MTR, MTRR
Defects in cobalamin (B12) metabolism (R-HSA-3296469)	-	9.28	0.009	MTR, MTRR
Metabolism (R-HSA-1430728)	-	2.34	0.03	SLC19A1, MTR, MTHFR, SDHC, SHMT1, MTRR, SDHB
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE (R-HSA-3359467)	-	11.98	0.0	MTR, MTRR
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG (R-HSA-3359469)	-	11.98	0.0	MTR, MTRR
Metabolism of water-soluble vitamins and cofactors (R-HSA-196849)	-	6.54	0.0	SLC19A1, MTR, MTRR, SHMT1, MTHFR
Cobalamin (Cbl, vitamin B12) transport and metabolism (R-HSA-196741)	-	8.73	0.034	MTR, MTRR

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	10	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
small molecule binding (GO:0036094)	1.89	8	FOLR1, SLC19A1, MTR, KIT, MTHFR, MTRR, SHMT1, PDGFRA
catalytic activity (GO:0003824)	1.05	8	MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
heterocyclic compound binding (GO:1901363)	1.06	8	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, PDGFRA
organic cyclic compound binding (GO:0097159)	1.05	8	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, PDGFRA
protein binding (GO:0005515)	0.46	7	MTR, KIT, MTHFR, MTRR, SHMT1, SDHB, PDGFRA
ion binding (GO:0043167)	1.36	6	FOLR1, MTR, KIT, SDHC, SHMT1, SDHB
cation binding (GO:0043169)	1.4	4	MTR, KIT, SDHC, SDHB
nucleotide binding (GO:0000166)	1.96	4	PDGFRA, KIT, MTRR, MTHFR
transferase activity (GO:0016740)	1.95	4	MTR, KIT, PDGFRA, SHMT1
cofactor binding (GO:0048037)	4.16	4	SHMT1, MTRR, SDHB, MTHFR
metal ion binding (GO:0046872)	1.41	4	MTR, KIT, SDHC, SDHB
nucleoside phosphate binding (GO:1901265)	1.96	4	PDGFRA, KIT, MTRR, MTHFR
oxidoreductase activity (GO:0016491)	3.12	4	SDHC, MTRR, SDHB, MTHFR
modified amino acid binding (GO:0072341)	5.56	3	FOLR1, SLC19A1, MTHFR
carbohydrate derivative binding (GO:0097367)	2.03	3	PDGFRA, KIT, MTRR
vitamin binding (GO:0019842)	5.34	3	FOLR1, SLC19A1, MTR
molecular transducer activity (GO:0060089)	2.32	3	FOLR1, PDGFRA, KIT
ribonucleotide binding (GO:0032553)	2.19	3	PDGFRA, KIT, MTRR
organic acid binding (GO:0043177)	6.6	3	FOLR1, SLC19A1, SHMT1
receptor activity (GO:0004872)	2.32	3	FOLR1, PDGFRA, KIT
protein dimerization activity (GO:0046983)	2.72	3	PDGFRA, KIT, SHMT1
identical protein binding (GO:0042802)	2.63	3	PDGFRA, KIT, SHMT1
protein homodimerization activity (GO:0042803)	3.16	3	PDGFRA, KIT, SHMT1
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	4.31	2	PDGFRA, KIT
folic acid transporter activity (GO:0008517)	7.79	2	FOLR1, SLC19A1
signaling receptor activity (GO:0038023)	2.49	2	PDGFRA, KIT
signal transducer activity (GO:0004871)	2.28	2	PDGFRA, KIT
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	2	PDGFRA, KIT
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	2	PDGFRA, KIT
protein kinase activity (GO:0004672)	3.27	2	PDGFRA, KIT
phosphatidylinositol 3-kinase activity (GO:0035004)	5.49	2	PDGFRA, KIT
methyltransferase activity (GO:0008168)	4.35	2	MTR, SHMT1
molecular function regulator (GO:0098772)	2.51	2	PDGFRA, KIT
purine nucleoside binding (GO:0001883)	2.22	2	PDGFRA, KIT
nucleoside binding (GO:0001882)	2.21	2	PDGFRA, KIT
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)	5.61	2	PDGFRA, KIT
cofactor transporter activity (GO:0051184)	6.69	2	FOLR1, SLC19A1
NADP binding (GO:0050661)	5.93	2	MTRR, MTHFR
succinate dehydrogenase activity (GO:0000104)	8.13	2	SDHC, SDHB
vitamin transporter activity (GO:0051183)	6.56	2	FOLR1, SLC19A1
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627)	5.66	2	SDHC, SDHB
transporter activity (GO:0005215)	2.57	2	FOLR1, SLC19A1
phosphatidylinositol bisphosphate kinase activity (GO:0052813)	5.56	2	PDGFRA, KIT
transmembrane receptor protein tyrosine kinase activity (GO:0004714)	5.55	2	PDGFRA, KIT
transferase activity, transferring one-carbon groups (GO:0016741)	4.3	2	MTR, SHMT1
protein tyrosine kinase activity (GO:0004713)	4.54	2	PDGFRA, KIT
ribonucleoside binding (GO:0032549)	2.22	2	PDGFRA, KIT
purine nucleotide binding (GO:0017076)	2.19	2	PDGFRA, KIT
ATP binding (GO:0005524)	2.43	2	PDGFRA, KIT
anion binding (GO:0043168)	4.17	2	FOLR1, SHMT1
folic acid binding (GO:0005542)	7.17	2	FOLR1, SLC19A1
coenzyme binding (GO:0050662)	4.53	2	MTRR, MTHFR
amide binding (GO:0033218)	4.14	2	FOLR1, SLC19A1
kinase activity (GO:0016301)	2.93	2	PDGFRA, KIT
flavin adenine dinucleotide binding (GO:0050660)	5.41	2	MTRR, MTHFR
electron carrier activity (GO:0009055)	4.97	2	SDHC, SDHB
tetrapyrrole binding (GO:0046906)	4.8	2	MTR, SDHC
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	2	PDGFRA, KIT
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	2	PDGFRA, KIT
adenyl nucleotide binding (GO:0030554)	2.4	2	PDGFRA, KIT
carboxylic acid binding (GO:0031406)	4.64	2	FOLR1, SHMT1
transmembrane signaling receptor activity (GO:0004888)	2.57	2	PDGFRA, KIT
adenyl ribonucleotide binding (GO:0032559)	2.41	2	PDGFRA, KIT
purine ribonucleotide binding (GO:0032555)	2.2	2	PDGFRA, KIT
transmembrane receptor protein kinase activity (GO:0019199)	5.32	2	PDGFRA, KIT
purine ribonucleoside binding (GO:0032550)	2.22	2	PDGFRA, KIT
transmembrane receptor activity (GO:0099600)	2.53	2	PDGFRA, KIT

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
anion binding (GO:0043168)	-	4.17	0.024	FOLR1, SLC19A1, KIT, MTHFR, SHMT1, MTRR, PDGFRA
cofactor transporter activity (GO:0051184)	-	6.69	0.006	FOLR1, SLC19A1
NADP binding (GO:0050661)	-	5.93	0.041	MTRR, MTHFR
modified amino acid binding (GO:0072341)	-	5.56	0.005	FOLR1, SLC19A1, MTHFR
vitamin transporter activity (GO:0051183)	-	6.56	0.018	FOLR1, SLC19A1
organic acid binding (GO:0043177)	-	6.6	0.0	FOLR1, SLC19A1, SHMT1, MTHFR
folic acid binding (GO:0005542)	-	7.17	0.001	FOLR1, SLC19A1
folic acid transporter activity (GO:0008517)	-	7.79	0.0	FOLR1, SLC19A1
carboxylic acid binding (GO:0031406)	-	4.64	0.0	FOLR1, SLC19A1, SHMT1, MTHFR
vitamin binding (GO:0019842)	-	5.34	0.028	FOLR1, SLC19A1, MTR
ion binding (GO:0043167)	-	1.36	0.006	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
small molecule binding (GO:0036094)	-	1.89	0.002	FOLR1, SLC19A1, MTR, KIT, MTHFR, MTRR, SHMT1, PDGFRA
cofactor binding (GO:0048037)	-	4.16	0.002	SHMT1, MTRR, SDHB, MTHFR
succinate dehydrogenase activity (GO:0000104)	-	8.13	0.0	SDHC, SDHB
amino acid binding (GO:0016597)	NEW	5.71	0.002	FOLR1, SLC19A1, SHMT1, MTHFR

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
single-organism metabolic process (GO:0044710)	1.63	10	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
cellular process (GO:0009987)	0.26	10	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
cellular metabolic process (GO:0044237)	0.69	10	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
organic substance metabolic process (GO:0071704)	0.63	10	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
single-organism cellular process (GO:0044763)	0.65	10	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
metabolic process (GO:0008152)	0.58	10	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
single-organism process (GO:0044699)	0.48	10	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
primary metabolic process (GO:0044238)	0.69	8	MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
small molecule metabolic process (GO:0044281)	2.38	8	FOLR1, SLC19A1, MTR, MTHFR, SDHC, MTRR, SHMT1, SDHB
organic acid metabolic process (GO:0006082)	3.01	8	FOLR1, SLC19A1, MTR, MTHFR, SDHC, MTRR, SHMT1, SDHB
nitrogen compound metabolic process (GO:0006807)	1.13	7	FOLR1, SLC19A1, MTR, KIT, MTHFR, SHMT1, MTRR
organonitrogen compound metabolic process (GO:1901564)	2.32	7	FOLR1, SLC19A1, MTR, KIT, MTHFR, SHMT1, MTRR
water-soluble vitamin metabolic process (GO:0006767)	5.29	6	FOLR1, SLC19A1, MTR, MTHFR, SHMT1, MTRR
vitamin metabolic process (GO:0006766)	4.97	6	FOLR1, SLC19A1, MTR, MTHFR, SHMT1, MTRR
response to stimulus (GO:0050896)	1.22	6	FOLR1, MTR, KIT, MTHFR, SHMT1, PDGFRA
cellular aromatic compound metabolic process (GO:0006725)	1.3	6	FOLR1, SLC19A1, MTR, MTHFR, SHMT1, MTRR
pteridine-containing compound metabolic process (GO:0042558)	6.17	6	FOLR1, SLC19A1, MTR, MTHFR, SHMT1, MTRR
cellular component organization (GO:0016043)	1.24	6	FOLR1, MTR, KIT, MTHFR, SHMT1, PDGFRA
organic cyclic compound metabolic process (GO:1901360)	1.26	6	FOLR1, SLC19A1, MTR, MTHFR, SHMT1, MTRR
response to chemical (GO:0042221)	1.98	6	FOLR1, MTR, KIT, MTHFR, SHMT1, PDGFRA
cellular component organization or biogenesis (GO:0071840)	1.22	6	FOLR1, MTR, KIT, MTHFR, SHMT1, PDGFRA
heterocycle metabolic process (GO:0046483)	1.31	6	FOLR1, SLC19A1, MTR, MTHFR, SHMT1, MTRR
response to oxygen-containing compound (GO:1901700)	2.57	5	FOLR1, SHMT1, MTR, PDGFRA, MTHFR
cellular response to stimulus (GO:0051716)	1.97	5	FOLR1, MTR, KIT, PDGFRA, SHMT1
cofactor metabolic process (GO:0051186)	3.91	5	FOLR1, SHMT1, SLC19A1, MTRR, MTHFR
cellular modified amino acid metabolic process (GO:0006575)	4.69	5	FOLR1, SHMT1, SLC19A1, MTRR, MTHFR
cellular amide metabolic process (GO:0043603)	3.23	5	SLC19A1, FOLR1, MTRR, SHMT1, MTHFR
coenzyme metabolic process (GO:0006732)	4.14	5	FOLR1, SHMT1, SLC19A1, MTRR, MTHFR
cellular nitrogen compound metabolic process (GO:0034641)	1.22	5	FOLR1, SHMT1, SLC19A1, MTRR, MTHFR
carboxylic acid metabolic process (GO:0019752)	3.12	5	SHMT1, MTR, MTRR, SDHB, MTHFR
response to stress (GO:0006950)	1.8	5	FOLR1, MTR, KIT, PDGFRA, MTHFR
biological regulation (GO:0065007)	0.39	5	FOLR1, PDGFRA, KIT, MTRR, MTHFR
cellular response to chemical stimulus (GO:0070887)	2.57	5	FOLR1, MTR, KIT, PDGFRA, SHMT1
oxoacid metabolic process (GO:0043436)	3.12	5	SHMT1, MTR, MTRR, SDHB, MTHFR
folic acid metabolic process (GO:0046655)	6.9	5	FOLR1, SHMT1, SLC19A1, MTRR, MTHFR
folic acid-containing compound metabolic process (GO:0006760)	6.4	5	FOLR1, SHMT1, SLC19A1, MTRR, MTHFR
developmental process (GO:0032502)	1.36	4	FOLR1, MTR, KIT, PDGFRA
cellular response to oxygen-containing compound (GO:1901701)	3.22	4	FOLR1, MTR, PDGFRA, SHMT1
anatomical structure development (GO:0048856)	1.58	4	FOLR1, MTR, KIT, PDGFRA
multicellular organismal process (GO:0032501)	1.45	4	SLC19A1, PDGFRA, KIT, MTHFR
cellular amino acid metabolic process (GO:0006520)	4.22	4	MTR, MTRR, SHMT1, MTHFR
regulation of cellular process (GO:0050794)	0.5	4	FOLR1, PDGFRA, KIT, MTHFR
single-organism developmental process (GO:0044767)	1.49	4	FOLR1, MTR, KIT, PDGFRA
cellular component assembly (GO:0022607)	2.14	4	FOLR1, PDGFRA, KIT, SHMT1
oxidation-reduction process (GO:0055114)	2.91	4	SDHC, MTRR, SDHB, MTHFR
macromolecule metabolic process (GO:0043170)	0.83	4	PDGFRA, KIT, SHMT1, MTRR
alpha-amino acid metabolic process (GO:1901605)	4.5	4	MTR, MTRR, SHMT1, MTHFR
regulation of biological process (GO:0050789)	0.45	4	FOLR1, PDGFRA, KIT, MTHFR
response to organic substance (GO:0010033)	2.2	4	FOLR1, KIT, SHMT1, MTHFR
regulation of primary metabolic process (GO:0080090)	1.08	3	PDGFRA, KIT, MTHFR
regulation of metabolic process (GO:0019222)	1.02	3	PDGFRA, KIT, MTHFR
cell projection organization (GO:0030030)	3.14	3	FOLR1, MTR, KIT
regulation of signaling (GO:0023051)	1.72	3	FOLR1, PDGFRA, KIT
regulation of response to stimulus (GO:0048583)	1.54	3	FOLR1, PDGFRA, KIT
regulation of cellular component organization (GO:0051128)	2.01	3	PDGFRA, KIT, MTHFR
cellular biosynthetic process (GO:0044249)	1.37	3	MTR, MTRR, SHMT1
aspartate family amino acid metabolic process (GO:0009066)	5.72	3	MTR, MTRR, MTHFR
small molecule biosynthetic process (GO:0044283)	3.79	3	MTR, MTRR, SHMT1
regulation of cell communication (GO:0010646)	1.73	3	FOLR1, PDGFRA, KIT
cell migration (GO:0016477)	3.12	3	FOLR1, PDGFRA, KIT
response to endogenous stimulus (GO:0009719)	2.79	3	FOLR1, KIT, MTHFR
organic substance biosynthetic process (GO:1901576)	1.34	3	MTR, MTRR, SHMT1
single-organism biosynthetic process (GO:0044711)	2.8	3	MTR, MTRR, SHMT1
cellular macromolecule metabolic process (GO:0044260)	0.93	3	PDGFRA, KIT, MTRR
regulation of signal transduction (GO:0009966)	1.84	3	FOLR1, PDGFRA, KIT
regulation of protein metabolic process (GO:0051246)	1.93	3	PDGFRA, KIT, MTHFR
response to wounding (GO:0009611)	4.39	3	FOLR1, MTR, PDGFRA
macromolecular complex subunit organization (GO:0043933)	2.14	3	FOLR1, SHMT1, MTHFR
transport (GO:0006810)	1.51	3	FOLR1, SLC19A1, KIT
regulation of protein modification process (GO:0031399)	2.32	3	PDGFRA, KIT, MTHFR
regulation of molecular function (GO:0065009)	1.78	3	PDGFRA, KIT, MTRR
methylation (GO:0032259)	4.06	3	MTR, MTRR, SHMT1
alpha-amino acid biosynthetic process (GO:1901607)	5.51	3	MTR, MTRR, SHMT1
organelle organization (GO:0006996)	2.02	3	FOLR1, PDGFRA, KIT
sulfur amino acid metabolic process (GO:0000096)	6.47	3	MTR, MTRR, MTHFR
biosynthetic process (GO:0009058)	1.32	3	MTR, MTRR, SHMT1
regulation of macromolecule metabolic process (GO:0060255)	1.08	3	PDGFRA, KIT, MTHFR
regulation of cellular metabolic process (GO:0031323)	1.07	3	PDGFRA, KIT, MTHFR
regulation of catalytic activity (GO:0050790)	1.97	3	PDGFRA, KIT, MTRR
movement of cell or subcellular component (GO:0006928)	2.61	3	FOLR1, PDGFRA, KIT
reproductive process (GO:0022414)	2.55	3	SLC19A1, PDGFRA, KIT
single-organism transport (GO:0044765)	2.18	3	FOLR1, SLC19A1, KIT
establishment of localization (GO:0051234)	1.48	3	FOLR1, SLC19A1, KIT
localization (GO:0051179)	1.4	3	SLC19A1, FOLR1, KIT
single-organism localization (GO:1902578)	2.09	3	FOLR1, SLC19A1, KIT
locomotion (GO:0040011)	2.91	3	FOLR1, PDGFRA, KIT
cellular amino acid biosynthetic process (GO:0008652)	5.49	3	MTR, MTRR, SHMT1
regulation of cellular protein metabolic process (GO:0032268)	1.99	3	PDGFRA, KIT, MTHFR
response to external stimulus (GO:0009605)	2.55	3	FOLR1, KIT, MTHFR
organonitrogen compound biosynthetic process (GO:1901566)	2.85	3	MTR, MTRR, SHMT1
cell motility (GO:0048870)	3.02	3	FOLR1, PDGFRA, KIT
protein metabolic process (GO:0019538)	1.45	3	PDGFRA, KIT, SHMT1
carbohydrate derivative metabolic process (GO:1901135)	3.07	3	KIT, MTRR, SHMT1
methionine metabolic process (GO:0006555)	6.84	3	MTR, MTRR, MTHFR
macromolecule modification (GO:0043412)	1.73	3	PDGFRA, KIT, MTRR
organic acid biosynthetic process (GO:0016053)	4.26	3	MTR, MTRR, SHMT1
carboxylic acid biosynthetic process (GO:0046394)	4.32	3	MTR, MTRR, SHMT1
phosphate-containing compound metabolic process (GO:0006796)	2.16	3	PDGFRA, KIT, SHMT1
sulfur compound metabolic process (GO:0006790)	3.87	3	MTR, MTRR, MTHFR
cellular response to stress (GO:0033554)	2.51	3	FOLR1, MTR, PDGFRA
phosphorus metabolic process (GO:0006793)	2.15	3	PDGFRA, KIT, SHMT1
organophosphate metabolic process (GO:0019637)	3.04	3	PDGFRA, KIT, SHMT1
response to nitrogen compound (GO:1901698)	3.12	3	FOLR1, MTR, MTHFR
regulation of phosphate metabolic process (GO:0019220)	2.35	2	PDGFRA, KIT
positive regulation of response to stimulus (GO:0048584)	2.18	2	PDGFRA, KIT
response to axon injury (GO:0048678)	5.86	2	FOLR1, MTR
signal transduction (GO:0007165)	1.28	2	PDGFRA, KIT
small molecule catabolic process (GO:0044282)	3.99	2	MTRR, SHMT1
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	2	PDGFRA, KIT
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	2	PDGFRA, KIT
signal transduction by protein phosphorylation (GO:0023014)	3.79	2	PDGFRA, KIT
single-organism catabolic process (GO:0044712)	3.21	2	MTRR, SHMT1
regulation of localization (GO:0032879)	1.94	2	PDGFRA, KIT
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	2	PDGFRA, KIT
taxis (GO:0042330)	4.03	2	PDGFRA, KIT
positive regulation of signal transduction (GO:0009967)	2.5	2	PDGFRA, KIT
MAPK cascade (GO:0000165)	3.91	2	PDGFRA, KIT
peptidyl-amino acid modification (GO:0018193)	2.98	2	PDGFRA, KIT
rhythmic process (GO:0048511)	4.02	2	PDGFRA, KIT
electron transport chain (GO:0022900)	5.09	2	SDHC, SDHB
positive regulation of lipid metabolic process (GO:0045834)	4.88	2	PDGFRA, KIT
positive regulation of molecular function (GO:0044093)	2.23	2	PDGFRA, KIT
respiratory electron transport chain (GO:0022904)	5.11	2	SDHC, SDHB
positive regulation of biological process (GO:0048518)	1.2	2	PDGFRA, KIT
negative regulation of biological process (GO:0048519)	1.33	2	PDGFRA, KIT
system process (GO:0003008)	2.3	2	KIT, MTHFR
S-adenosylmethionine metabolic process (GO:0046500)	6.84	2	MTRR, MTHFR
regulation of cell proliferation (GO:0042127)	2.41	2	PDGFRA, KIT
aspartate family amino acid biosynthetic process (GO:0009067)	6.59	2	MTR, MTRR
axon regeneration (GO:0031103)	6.64	2	FOLR1, MTR
neuron projection regeneration (GO:0031102)	6.29	2	FOLR1, MTR
organic acid transport (GO:0015849)	4.93	2	FOLR1, SLC19A1
tetrahydrofolate metabolic process (GO:0046653)	6.73	2	SHMT1, MTHFR
response to folic acid (GO:0051593)	7.02	2	FOLR1, MTHFR
regulation of phospholipase C activity (GO:1900274)	6.07	2	PDGFRA, KIT
phosphatidylinositol metabolic process (GO:0046488)	4.46	2	PDGFRA, KIT
glycerolipid metabolic process (GO:0046486)	3.91	2	PDGFRA, KIT
multi-organism process (GO:0051704)	2.65	2	SLC19A1, PDGFRA
regulation of phosphorylation (GO:0042325)	2.5	2	PDGFRA, KIT
cellular catabolic process (GO:0044248)	2.62	2	MTRR, SHMT1
positive regulation of phosphorylation (GO:0042327)	2.9	2	PDGFRA, KIT
single organism reproductive process (GO:0044702)	2.73	2	PDGFRA, KIT
organonitrogen compound catabolic process (GO:1901565)	3.91	2	MTRR, SHMT1
single-multicellular organism process (GO:0044707)	1.78	2	PDGFRA, KIT
response to organonitrogen compound (GO:0010243)	3.2	2	FOLR1, MTHFR
response to nutrient levels (GO:0031667)	3.77	2	FOLR1, MTHFR
organic acid catabolic process (GO:0016054)	4.44	2	MTRR, SHMT1
response to acid chemical (GO:0001101)	4.05	2	FOLR1, MTHFR
positive regulation of GTPase activity (GO:0043547)	3.28	2	PDGFRA, KIT
positive regulation of metabolic process (GO:0009893)	1.74	2	PDGFRA, KIT
ovulation cycle process (GO:0022602)	5.25	2	PDGFRA, KIT
positive regulation of kinase activity (GO:0033674)	3.54	2	PDGFRA, KIT
cell chemotaxis (GO:0060326)	4.63	2	PDGFRA, KIT
positive regulation of cell migration (GO:0030335)	3.77	2	PDGFRA, KIT
response to reactive oxygen species (GO:0000302)	4.5	2	MTR, PDGFRA
aerobic respiration (GO:0009060)	6.4	2	SDHC, SDHB
vesicle-mediated transport (GO:0016192)	2.72	2	FOLR1, KIT
positive regulation of phospholipase C activity (GO:0010863)	6.15	2	PDGFRA, KIT
neuron projection development (GO:0031175)	4.58	2	FOLR1, MTR
actin filament-based process (GO:0030029)	3.94	2	PDGFRA, KIT
intracellular signal transduction (GO:0035556)	2.39	2	PDGFRA, KIT
ameboidal-type cell migration (GO:0001667)	4.71	2	FOLR1, KIT
cellular protein metabolic process (GO:0044267)	1.63	2	PDGFRA, KIT
organic substance catabolic process (GO:1901575)	2.45	2	MTRR, SHMT1
positive regulation of transferase activity (GO:0051347)	3.31	2	PDGFRA, KIT
vitamin transport (GO:0051180)	6.2	2	FOLR1, SLC19A1
positive regulation of hydrolase activity (GO:0051345)	2.91	2	PDGFRA, KIT
regulation of kinase activity (GO:0043549)	3.07	2	PDGFRA, KIT
tetrahydrofolate interconversion (GO:0035999)	7.33	2	SHMT1, MTHFR
macromolecular complex assembly (GO:0065003)	2.55	2	FOLR1, SHMT1
tetrapyrrole metabolic process (GO:0033013)	5.65	2	MTR, MTRR
positive regulation of catalytic activity (GO:0043085)	2.4	2	PDGFRA, KIT
phosphatidylinositol phosphorylation (GO:0046854)	5.19	2	PDGFRA, KIT
regulation of biological quality (GO:0065008)	1.68	2	PDGFRA, KIT
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	2	FOLR1, PDGFRA
single organism cell adhesion (GO:0098602)	3.63	2	PDGFRA, KIT
axon development (GO:0061564)	6.36	2	FOLR1, MTR
lipid metabolic process (GO:0006629)	2.68	2	PDGFRA, KIT
positive regulation of lipid kinase activity (GO:0090218)	6.23	2	PDGFRA, KIT
cell-cell adhesion (GO:0098609)	3.34	2	PDGFRA, KIT
regulation of biosynthetic process (GO:0009889)	1.37	2	PDGFRA, KIT
positive regulation of MAPK cascade (GO:0043410)	3.57	2	PDGFRA, KIT
cell activation (GO:0001775)	3.47	2	PDGFRA, KIT
protein modification process (GO:0036211)	1.79	2	PDGFRA, KIT
cellular respiration (GO:0045333)	5.9	2	SDHC, SDHB
regulation of multicellular organismal process (GO:0051239)	1.87	2	PDGFRA, KIT
positive regulation of intracellular signal transduction (GO:1902533)	2.95	2	PDGFRA, KIT
regulation of intracellular signal transduction (GO:1902531)	2.31	2	PDGFRA, KIT
phosphatidylinositol-mediated signaling (GO:0048015)	4.93	2	PDGFRA, KIT
inositol lipid-mediated signaling (GO:0048017)	4.91	2	PDGFRA, KIT
regulation of hydrolase activity (GO:0051336)	2.53	2	PDGFRA, KIT
regulation of lipid kinase activity (GO:0043550)	5.84	2	PDGFRA, KIT
positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)	6.29	2	PDGFRA, KIT
energy derivation by oxidation of organic compounds (GO:0015980)	4.93	2	SDHC, SDHB
intracellular transport (GO:0046907)	2.67	2	FOLR1, KIT
positive regulation of protein modification process (GO:0031401)	2.7	2	PDGFRA, KIT
regulation of transferase activity (GO:0051338)	2.88	2	PDGFRA, KIT
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	2	PDGFRA, KIT
regulation of cell motility (GO:2000145)	3.16	2	PDGFRA, KIT
positive regulation of cell motility (GO:2000147)	3.74	2	PDGFRA, KIT
positive regulation of lipase activity (GO:0060193)	5.54	2	PDGFRA, KIT
regulation of lipase activity (GO:0060191)	5.31	2	PDGFRA, KIT
regulation of organelle organization (GO:0033043)	2.72	2	PDGFRA, MTHFR
peptidyl-tyrosine modification (GO:0018212)	4.47	2	PDGFRA, KIT
one-carbon metabolic process (GO:0006730)	6.15	2	SHMT1, MTHFR
positive regulation of signaling (GO:0023056)	2.41	2	PDGFRA, KIT
positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068)	5.59	2	PDGFRA, KIT
regulation of phospholipid metabolic process (GO:1903725)	5.69	2	PDGFRA, KIT
positive regulation of cell communication (GO:0010647)	2.41	2	PDGFRA, KIT
anatomical structure morphogenesis (GO:0009653)	2.53	2	FOLR1, PDGFRA
regulation of GTPase activity (GO:0043087)	3.21	2	PDGFRA, KIT
protein autophosphorylation (GO:0046777)	4.46	2	PDGFRA, KIT
response to organic cyclic compound (GO:0014070)	3.07	2	FOLR1, MTHFR
regulation of MAPK cascade (GO:0043408)	3.22	2	PDGFRA, KIT
nucleobase-containing compound metabolic process (GO:0006139)	1.35	2	MTRR, SHMT1
amide transport (GO:0042886)	5.19	2	FOLR1, SLC19A1
positive regulation of phospholipid metabolic process (GO:1903727)	5.99	2	PDGFRA, KIT
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	PDGFRA, KIT
regeneration (GO:0031099)	4.7	2	FOLR1, MTR
positive regulation of protein metabolic process (GO:0051247)	2.43	2	PDGFRA, KIT
lipid phosphorylation (GO:0046834)	5.13	2	PDGFRA, KIT
response to vitamin (GO:0033273)	5.11	2	FOLR1, MTHFR
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	PDGFRA, KIT
biological adhesion (GO:0022610)	2.81	2	PDGFRA, KIT
alpha-amino acid catabolic process (GO:1901606)	5.54	2	MTRR, SHMT1
positive regulation of cell proliferation (GO:0008284)	3.01	2	PDGFRA, KIT
regulation of phosphatidylinositol 3-kinase activity (GO:0043551)	6.02	2	PDGFRA, KIT
phospholipid metabolic process (GO:0006644)	3.88	2	PDGFRA, KIT
response to abiotic stimulus (GO:0009628)	2.8	2	KIT, MTHFR
regulation of cell differentiation (GO:0045595)	2.42	2	PDGFRA, KIT
regulation of locomotion (GO:0040012)	3.12	2	PDGFRA, KIT
actin cytoskeleton organization (GO:0030036)	4.1	2	PDGFRA, KIT
cellular lipid metabolic process (GO:0044255)	2.92	2	PDGFRA, KIT
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)	4.79	2	PDGFRA, KIT
lipid modification (GO:0030258)	4.37	2	PDGFRA, KIT
response to oxidative stress (GO:0006979)	3.9	2	MTR, PDGFRA
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	2	MTRR, SHMT1
folic acid transport (GO:0015884)	7.65	2	FOLR1, SLC19A1
phosphorylation (GO:0016310)	2.63	2	PDGFRA, KIT
system development (GO:0048731)	2.92	2	MTR, PDGFRA
methionine biosynthetic process (GO:0009086)	7.09	2	MTR, MTRR
cellular response to endogenous stimulus (GO:0071495)	3.33	2	FOLR1, KIT
response to extracellular stimulus (GO:0009991)	3.71	2	FOLR1, MTHFR
cellular response to nitrogen compound (GO:1901699)	3.79	2	FOLR1, MTR
single organismal cell-cell adhesion (GO:0016337)	3.69	2	PDGFRA, KIT
glycerophospholipid metabolic process (GO:0006650)	4.13	2	PDGFRA, KIT
regulation of cellular biosynthetic process (GO:0031326)	1.38	2	PDGFRA, KIT
positive regulation of cellular metabolic process (GO:0031325)	1.81	2	PDGFRA, KIT
cobalamin metabolic process (GO:0009235)	6.68	2	MTR, MTRR
peptidyl-tyrosine phosphorylation (GO:0018108)	4.48	2	PDGFRA, KIT
tricarboxylic acid cycle (GO:0006099)	6.33	2	SDHC, SDHB
purine-containing compound metabolic process (GO:0072521)	4.0	2	MTRR, SHMT1
generation of precursor metabolites and energy (GO:0006091)	4.07	2	SDHC, SDHB
modified amino acid transport (GO:0072337)	6.51	2	FOLR1, SLC19A1
chemotaxis (GO:0006935)	4.04	2	PDGFRA, KIT
homocysteine metabolic process (GO:0050667)	7.33	2	MTRR, MTHFR
protein complex subunit organization (GO:0071822)	2.6	2	FOLR1, SHMT1
cell surface receptor signaling pathway (GO:0007166)	2.09	2	PDGFRA, KIT
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	2	PDGFRA, KIT
nitrogen compound transport (GO:0071705)	3.54	2	FOLR1, SLC19A1
cellular response to organic substance (GO:0071310)	2.78	2	FOLR1, KIT
organic substance transport (GO:0071702)	2.15	2	FOLR1, SLC19A1
embryonic morphogenesis (GO:0048598)	3.72	2	FOLR1, PDGFRA
protein phosphorylation (GO:0006468)	2.89	2	PDGFRA, KIT
regulation of cell migration (GO:0030334)	3.23	2	PDGFRA, KIT
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	PDGFRA, KIT
regulation of lipid metabolic process (GO:0019216)	4.08	2	PDGFRA, KIT
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	2	PDGFRA, KIT
response to nutrient (GO:0007584)	4.49	2	FOLR1, MTHFR
protein complex assembly (GO:0006461)	2.78	2	FOLR1, SHMT1
cellular response to reactive oxygen species (GO:0034614)	5.22	2	MTR, PDGFRA
cellular protein modification process (GO:0006464)	1.79	2	PDGFRA, KIT
regulation of phosphorus metabolic process (GO:0051174)	2.35	2	PDGFRA, KIT
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	2	PDGFRA, KIT
establishment of localization in cell (GO:0051649)	2.47	2	FOLR1, KIT
cell adhesion (GO:0007155)	2.82	2	PDGFRA, KIT
cofactor transport (GO:0051181)	6.47	2	FOLR1, SLC19A1
cellular response to oxidative stress (GO:0034599)	4.7	2	MTR, PDGFRA
catabolic process (GO:0009056)	2.38	2	MTRR, SHMT1
cellular localization (GO:0051641)	2.32	2	FOLR1, KIT
positive regulation of cellular component movement (GO:0051272)	3.71	2	PDGFRA, KIT
regulation of cellular component movement (GO:0051270)	3.08	2	PDGFRA, KIT
cytoskeleton organization (GO:0007010)	3.22	2	PDGFRA, KIT
positive regulation of locomotion (GO:0040017)	3.71	2	PDGFRA, KIT
positive regulation of phospholipase activity (GO:0010518)	5.76	2	PDGFRA, KIT
single-organism organelle organization (GO:1902589)	2.68	2	PDGFRA, KIT
regulation of phospholipase activity (GO:0010517)	5.57	2	PDGFRA, KIT
serine family amino acid metabolic process (GO:0009069)	6.02	2	MTRR, SHMT1
regulation of protein phosphorylation (GO:0001932)	2.57	2	PDGFRA, KIT
positive regulation of protein phosphorylation (GO:0001934)	2.95	2	PDGFRA, KIT
negative regulation of cellular process (GO:0048523)	1.41	2	PDGFRA, KIT
positive regulation of cellular process (GO:0048522)	1.3	2	PDGFRA, KIT

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
coenzyme metabolic process (GO:0006732)	-	4.14	0.001	FOLR1, SHMT1, SLC19A1, MTRR, MTHFR
cobalamin metabolic process (GO:0009235)	-	6.68	0.032	MTR, MTRR
carboxylic acid metabolic process (GO:0019752)	-	3.12	0.0	FOLR1, SLC19A1, MTR, MTHFR, MTRR, SHMT1, SDHB
aerobic respiration (GO:0009060)	-	6.4	0.039	SDHC, SDHB
aspartate family amino acid biosynthetic process (GO:0009067)	-	6.59	0.0	MTR, MTRR, MTHFR
small molecule metabolic process (GO:0044281)	-	2.38	0.006	FOLR1, SLC19A1, MTR, MTHFR, SDHC, MTRR, SHMT1, SDHB
small molecule biosynthetic process (GO:0044283)	-	3.79	0.027	MTR, MTRR, SHMT1, MTHFR
modified amino acid transport (GO:0072337)	-	6.51	0.029	FOLR1, SLC19A1
folic acid metabolic process (GO:0046655)	-	6.9	0.0	SLC19A1, FOLR1, MTRR, SHMT1, MTHFR
tetrahydrofolate metabolic process (GO:0046653)	-	6.73	0.029	SHMT1, MTHFR
single-organism metabolic process (GO:0044710)	-	1.63	0.001	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
cofactor metabolic process (GO:0051186)	-	3.91	0.007	FOLR1, SHMT1, SLC19A1, MTRR, MTHFR
cofactor transport (GO:0051181)	-	6.47	0.043	FOLR1, SLC19A1
cellular amino acid metabolic process (GO:0006520)	-	4.22	0.006	FOLR1, SLC19A1, MTR, MTHFR, SHMT1, MTRR
tetrahydrofolate interconversion (GO:0035999)	-	7.33	0.034	SHMT1, MTHFR
pteridine-containing compound metabolic process (GO:0042558)	-	6.17	0.0	FOLR1, SLC19A1, MTR, MTHFR, SHMT1, MTRR
alpha-amino acid metabolic process (GO:1901605)	-	4.5	0.0	FOLR1, SLC19A1, MTR, MTHFR, SHMT1, MTRR
alpha-amino acid biosynthetic process (GO:1901607)	-	5.51	0.0	MTR, MTRR, SHMT1, MTHFR
water-soluble vitamin metabolic process (GO:0006767)	-	5.29	0.0	FOLR1, SLC19A1, MTR, MTHFR, SHMT1, MTRR
vitamin metabolic process (GO:0006766)	-	4.97	0.0	FOLR1, SLC19A1, MTR, MTHFR, SHMT1, MTRR
folic acid-containing compound metabolic process (GO:0006760)	-	6.4	0.0	SLC19A1, FOLR1, MTRR, SHMT1, MTHFR
cellular amino acid biosynthetic process (GO:0008652)	-	5.49	0.003	MTR, MTRR, SHMT1, MTHFR
sulfur amino acid biosynthetic process (GO:0000097)	NEW	8.34	0.0	MTR, MTRR, MTHFR
sulfur amino acid metabolic process (GO:0000096)	-	6.47	0.001	MTR, MTRR, MTHFR
oxoacid metabolic process (GO:0043436)	-	3.12	0.0	FOLR1, SLC19A1, MTR, MTHFR, MTRR, SHMT1, SDHB
dicarboxylic acid metabolic process (GO:0043648)	NEW	5.3	0.0	FOLR1, SLC19A1, MTHFR, MTRR, SHMT1, SDHB
organonitrogen compound metabolic process (GO:1901564)	-	2.32	0.006	FOLR1, SLC19A1, MTR, KIT, MTHFR, SHMT1, MTRR
cellular modified amino acid metabolic process (GO:0006575)	-	4.69	0.0	SLC19A1, FOLR1, MTRR, SHMT1, MTHFR
organic acid metabolic process (GO:0006082)	-	3.01	0.0	FOLR1, SLC19A1, MTR, MTHFR, MTRR, SHMT1, SDHB
sulfur compound biosynthetic process (GO:0044272)	NEW	4.5	0.037	MTR, MTRR, MTHFR
folic acid transport (GO:0015884)	-	7.65	0.004	FOLR1, SLC19A1
methionine metabolic process (GO:0006555)	-	6.84	0.0	MTR, MTRR, MTHFR
organic acid biosynthetic process (GO:0016053)	-	4.26	0.006	MTR, MTRR, SHMT1, MTHFR
carboxylic acid biosynthetic process (GO:0046394)	-	4.32	0.006	MTR, MTRR, SHMT1, MTHFR
methionine biosynthetic process (GO:0009086)	-	7.09	0.0	MTR, MTRR, MTHFR
aspartate family amino acid metabolic process (GO:0009066)	-	5.72	0.004	MTR, MTRR, MTHFR

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	10	FOLR1, SLC19A1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
intracellular part (GO:0044424)	0.28	9	FOLR1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB, PDGFRA
cytoplasmic part (GO:0044444)	0.82	8	FOLR1, MTR, KIT, MTHFR, SDHC, MTRR, SHMT1, SDHB
intracellular organelle (GO:0043229)	0.51	7	FOLR1, SDHC, KIT, MTRR, SHMT1, SDHB, PDGFRA
organelle (GO:0043226)	0.4	7	FOLR1, SDHC, KIT, MTRR, SHMT1, SDHB, PDGFRA
membrane part (GO:0044425)	0.95	6	FOLR1, SLC19A1, SDHC, KIT, SDHB, PDGFRA
membrane (GO:0016020)	0.68	6	FOLR1, SLC19A1, SDHC, KIT, SDHB, PDGFRA
membrane-bounded organelle (GO:0043227)	0.47	6	FOLR1, SDHC, KIT, SHMT1, SDHB, PDGFRA
intracellular membrane-bounded organelle (GO:0043231)	0.6	6	FOLR1, SDHC, KIT, SHMT1, SDHB, PDGFRA
cytoplasm (GO:0005737)	1.01	5	SHMT1, MTR, KIT, PDGFRA, MTRR
integral component of membrane (GO:0016021)	1.14	5	SLC19A1, FOLR1, SDHC, KIT, PDGFRA
intrinsic component of membrane (GO:0031224)	1.13	5	FOLR1, SLC19A1, SDHC, KIT, PDGFRA
plasma membrane (GO:0005886)	1.39	5	FOLR1, SLC19A1, PDGFRA, KIT, SDHB
vesicle (GO:0031982)	1.64	4	FOLR1, KIT, SHMT1, SDHB
cytosol (GO:0005829)	1.68	4	MTR, MTRR, SHMT1, MTHFR
membrane-bounded vesicle (GO:0031988)	1.71	4	FOLR1, KIT, SHMT1, SDHB
intracellular organelle part (GO:0044446)	0.81	4	FOLR1, SDHC, MTRR, SDHB
plasma membrane part (GO:0044459)	1.95	4	FOLR1, SLC19A1, PDGFRA, KIT
extracellular region part (GO:0044421)	1.57	4	FOLR1, KIT, SHMT1, SDHB
organelle part (GO:0044422)	0.79	4	FOLR1, SDHC, MTRR, SDHB
protein complex (GO:0043234)	1.51	3	PDGFRA, SDHC, SDHB
extracellular organelle (GO:0043230)	1.89	3	FOLR1, SHMT1, SDHB
organelle membrane (GO:0031090)	1.97	3	FOLR1, SDHC, SDHB
nucleus (GO:0005634)	1.07	3	FOLR1, PDGFRA, SHMT1
mitochondrion (GO:0005739)	2.42	3	SDHC, SHMT1, SDHB
integral component of plasma membrane (GO:0005887)	2.57	3	FOLR1, SLC19A1, PDGFRA
macromolecular complex (GO:0032991)	1.35	3	PDGFRA, SDHC, SDHB
extracellular vesicle (GO:1903561)	1.89	3	FOLR1, SHMT1, SDHB
intrinsic component of plasma membrane (GO:0031226)	2.53	3	FOLR1, SLC19A1, PDGFRA
extracellular exosome (GO:0070062)	1.89	3	FOLR1, SHMT1, SDHB
plasma membrane region (GO:0098590)	2.97	2	FOLR1, SLC19A1
respiratory chain complex (GO:0098803)	5.47	2	SDHC, SDHB
oxidoreductase complex (GO:1990204)	5.19	2	SDHC, SDHB
mitochondrial membrane part (GO:0044455)	4.54	2	SDHC, SDHB
membrane protein complex (GO:0098796)	2.84	2	SDHC, SDHB
vacuole (GO:0005773)	2.92	2	FOLR1, KIT
cytoplasmic vesicle (GO:0031410)	2.87	2	FOLR1, KIT
fumarate reductase complex (GO:0045283)	8.42	2	SDHC, SDHB
succinate dehydrogenase complex (GO:0045281)	8.42	2	SDHC, SDHB
inner mitochondrial membrane protein complex (GO:0098800)	5.01	2	SDHC, SDHB
nucleoplasm (GO:0005654)	1.89	2	MTRR, SDHB
catalytic complex (GO:1902494)	2.9	2	SDHC, SDHB
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	2	FOLR1, KIT
apical plasma membrane (GO:0016324)	4.13	2	FOLR1, SLC19A1
cell surface (GO:0009986)	3.44	2	FOLR1, KIT
cell projection membrane (GO:0031253)	4.11	2	FOLR1, SLC19A1
mitochondrial membrane (GO:0031966)	3.31	2	SDHC, SDHB
intracellular vesicle (GO:0097708)	2.86	2	FOLR1, KIT
basolateral plasma membrane (GO:0016323)	4.56	2	FOLR1, SLC19A1
respiratory chain complex II (GO:0045273)	9.11	2	SDHC, SDHB
succinate dehydrogenase complex (ubiquinone) (GO:0045257)	8.42	2	SDHC, SDHB
cell projection part (GO:0044463)	2.97	2	FOLR1, SLC19A1
organelle inner membrane (GO:0019866)	3.56	2	SDHC, SDHB
brush border membrane (GO:0031526)	5.78	2	FOLR1, SLC19A1
mitochondrial inner membrane (GO:0005743)	3.65	2	SDHC, SDHB
nuclear part (GO:0044428)	1.55	2	MTRR, SDHB
mitochondrial part (GO:0044429)	2.92	2	SDHC, SDHB
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) (GO:0005749)	8.42	2	SDHC, SDHB
mitochondrial protein complex (GO:0098798)	4.78	2	SDHC, SDHB

NET-GE enrichment

Term	New enriched term	IC	Genes
succinate dehydrogenase complex (ubiquinone) (GO:0045257)	-	8.42	SDHC, SDHB
mitochondrial respiratory chain complex II (GO:0005749)	-	8.42	SDHC, SDHB
fumarate reductase complex (GO:0045283)	-	8.42	SDHC, SDHB
succinate dehydrogenase complex (GO:0045281)	-	8.42	SDHC, SDHB