Disease table of COWDEN DISEASE OMIM ID: PS158350

Gene-disease associations table

Gene	Associated with COWDEN DISEASE in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
SEC23B	ClinVar, OMIM	HGNC link	20p11.23	2	PS224120, PS158350
AKT1	ClinVar, OMIM, HUMSAVAR	HGNC link	14q32.33	6	167000, 176920, 114480, 181500, 114500, PS158350
PIK3CA	ClinVar, OMIM, HUMSAVAR	HGNC link	3q26.32	11	114550, PS158350, 167000, 612918, 211980, 114480, 602501, 114500, 182000, 162900, 613659
KLLN	ClinVar, OMIM	HGNC link	10q23.31	1	PS158350
PTEN	ClinVar, OMIM, HUMSAVAR	HGNC link	10q23.31	10	276950, 608089, 275355, 176807, PS155600, PS137800, 605309, 607174, 153480, PS158350
SDHB	ClinVar, OMIM	HGNC link	1p36.13	6	171300, 604287, 606764, 606864, PS168000, PS158350
SDHD	ClinVar, OMIM	HGNC link	11q23.1	6	252011, PS168000, 606864, 114900, 171300, PS158350

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
10q23.31	2	KLLN, PTEN

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
10q23	2	KLLN, PTEN

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
10q2	2	KLLN, PTEN

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
10q	2	KLLN, PTEN

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
10	2	KLLN, PTEN

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	2	PTEN, AKT1
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	2	PTEN, AKT1
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	2	PTEN, AKT1
AR	NO	83	UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA1	2	PTEN, AKT1
TP53	NO	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	2	PTEN, AKT1

regulated gene	associated to this disease	# TFs	TFs
AKT1	YES	7	APC, STAT3, GLI1, AR, TP53, RELA, NFKB1
PIK3CA	YES	1	FOXO3
PTEN	YES	15	SP1, STAT3, EGR1, TCF4, NFKB1, MTA1, AR, TP53, HES1, TFAP2A, RELA, RBPJ, MXD1, PPARG, SRF
SDHB	YES	4	NRF1, NFE2L2, PLAGL1, HIF1A

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
SEC23B	AKT1	No	1	NF2
SEC23B	PIK3CA	No	1	NTRK1
SEC23B	PTEN	No	1	PXN
SEC23B	SDHB	No	3	TMED2, CUL3, CAND1
AKT1	PIK3CA	Yes	12	IL13RA2, IL24, AKT1, NOTCH1, IRS1, DDX5, ERBB3, SMAD2, ESR1, SMAD3, THRSP, APPL1
AKT1	PTEN	Yes	26	KAT2B, AR, USP8, XIAP, PPP1CA, HSP90AB1, AKT1, STUB1, USP4, PPL, CTNNB1, PINK1, CALM1, HSP90AA1, SLC9A3R1, PKN2, PPP3CA, IL24, HSPA8, CSNK2A1, OSGIN1, FASN, TUBB, PPP2R4, ESR1, NEDD4
AKT1	SDHB	No	2	IQGAP1, LDHA
PIK3CA	PTEN	No	7	IL24, AKT1, CBL, IRS4, RPS20, ESR1, BEX1
PIK3CA	SDHB	No	1	GSN
PTEN	SDHB	No	1	SLC25A3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
SEC23B	AKT1	No	-	2	UBC, SEC24B
SEC23B	PTEN	No	-	1	UBC
SEC23B	SDHB	No	-	1	UBC
AKT1	PIK3CA	Yes	activation, binding	108	ITGB3, PTEN, PLCG1, TP53, CDC42, SOS1, RAP1A, PDGFB, ACTN4, PDGFRB, ACTA1, CTNNB1, GNGT1, BECN1, BDNF, PIK3CB, RELA, CBLB, RELN, IL2, RRAS2, MTOR, INS, JAK1, PIK3R5, GNB1, ESR1, VAV2, FLT3, BCL2L1, AKT2, ITGA2B, RPTOR, PGF, ANGPT2, ITGA6, RHOA, PREX1, PIK3R1, BCR, RPS6KB2, APPL1, IGF1, PTPN1, CDH1, PIK3R3, PDPK1, ITGB4, GRB2, GAB1, PIK3CD, ZYX, PELP1, VLDLR, AR, CSK, TPTE2, RAP1B, DAB1, INSR, GSK3B, CCND1, CREB1, SMAD3, RAF1, ERBB3, TPTE, LCK, HRAS, NOTCH1, GAB2, DOK1, CDH2, VEGFA, RAC1, RICTOR, PRKCZ, GNAI3, CASP9, IL2RB, EFNA1, RAC3, PTPN11, MAP3K5, PIK3CG, GNAI1, DAB2IP, ANGPT1, RRAS, SHC1, YWHAZ, CSF2, TSC1, S1PR1, SLC9A3R1, SMAD2, SRC, NFKB1, MYC, STAT3, KRAS, IL3, ARF6, RPS6KB1, IRS1, VAV1, IRS2, LAT
AKT1	PTEN	Yes	activation, binding	74	KAT2B, AR, RPS6KB1, PIK3CG, FOXM1, TP53, XIAP, SNAI1, AKT2, SMAD4, NEDD4, PIK3R3, MMP2, EZH2, CREB1, PEA15, RETN, RPTOR, HDAC9, FOS, PDGFB, BCR, GRB2, IL18, PHLPP2, PHLPP1, PDGFRB, PLXNB1, THBS1, PIK3CA, MME, BMI1, PPP3CA, SMAD3, CHUK, MTOR, SOS1, TGFB1, FOXO3, BIRC5, ESR1, CDKN1A, BMP2, TSC2, NOTCH1, CDH1, EGR1, ATF2, SLC9A3R1, JUN, RAC3, TIMP1, SRC, VEGFA, SHC1, PIK3CB, MAP2K4, BAX, INSR, BCL2, CCND1, IKBKB, CAV1, IGF2, INS, LEP, PIK3R1, CDKN1B, MAPK14, UBC, PIK3CD, PIK3R5, PARK7, HIF1A
AKT1	SDHB	No	-	2	UBC, HSPA5
AKT1	SDHD	No	-	1	IL2
PIK3CA	PTEN	Yes	activation, binding	48	EPHB4, AKT1, PIK3CG, AR, VCL, SRC, AKT3, INSR, INSRR, CREB1, EGFR, PDGFB, EPHB1, VEGFA, DLG1, SP1, PDGFRB, PIK3R5, PTK2, IRS4, SMAD3, BCR, SOS1, SHC1, AKT2, NGFR, CDH1, RPS6KB1, PIK3CB, TP53, PIK3R3, PXN, PDGFRA, GRB2, NOTCH1, ITGB1, CBL, RPTOR, MTOR, INS, PIK3R1, BCAR1, ESR1, PIK3CD, CCND1, IGF1R, RAC3, SLC9A3R1
PIK3CA	SDHD	No	-	1	IL2
PTEN	SDHB	No	-	1	UBC
SDHB	SDHD	Yes	binding	2	SDHC, SDHA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

Gene1	Gene2	Direct interaction	More information
SDHB	SDHD	yes, complex	Components of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51	4	SDHD, SDHB, AKT1, PIK3CA
Melanoma	hsa05218	6.56	3	AKT1, PIK3CA, PTEN
Focal adhesion	hsa04510	4.92	3	AKT1, PTEN, PIK3CA
Endometrial cancer	hsa05213	6.81	3	AKT1, PIK3CA, PTEN
Pathways in cancer	hsa05200	3.98	3	AKT1, PTEN, PIK3CA
Glioma	hsa05214	6.66	3	AKT1, PTEN, PIK3CA
Prostate cancer	hsa05215	6.11	3	AKT1, PIK3CA, PTEN
Central carbon metabolism in cancer	hsa05230	6.7	3	AKT1, PIK3CA, PTEN
Small cell lung cancer	hsa05222	6.17	3	AKT1, PIK3CA, PTEN
FoxO signaling pathway	hsa04068	5.63	3	AKT1, PIK3CA, PTEN
Hepatitis B	hsa05161	5.52	3	AKT1, PTEN, PIK3CA
mTOR signaling pathway	hsa04150	6.72	3	AKT1, PIK3CA, PTEN
PI3K-Akt signaling pathway	hsa04151	4.21	3	AKT1, PTEN, PIK3CA
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6	2	AKT1, PIK3CA
Platelet activation	hsa04611	5.66	2	PIK3CA, AKT1
Fc gamma R-mediated phagocytosis	hsa04666	6.21	2	PIK3CA, AKT1
cGMP-PKG signaling pathway	hsa04022	5.32	2	AKT1, PIK3CA
Colorectal cancer	hsa05210	6.52	2	PIK3CA, AKT1
Renal cell carcinoma	hsa05211	6.6	2	AKT1, PIK3CA
cAMP signaling pathway	hsa04024	5.05	2	PIK3CA, AKT1
Jak-STAT signaling pathway	hsa04630	5.44	2	AKT1, PIK3CA
Tight junction	hsa04530	5.53	2	AKT1, PTEN
Neurotrophin signaling pathway	hsa04722	5.78	2	PIK3CA, AKT1
Cholinergic synapse	hsa04725	5.88	2	AKT1, PIK3CA
Choline metabolism in cancer	hsa05231	6.09	2	PIK3CA, AKT1
Osteoclast differentiation	hsa04380	5.64	2	PIK3CA, AKT1
HIF-1 signaling pathway	hsa04066	5.9	2	AKT1, PIK3CA
Chemokine signaling pathway	hsa04062	5.19	2	AKT1, PIK3CA
Inositol phosphate metabolism	hsa00562	6.72	2	PIK3CA, PTEN
Progesterone-mediated oocyte maturation	hsa04914	6.18	2	AKT1, PIK3CA
Chagas disease (American trypanosomiasis)	hsa05142	5.99	2	AKT1, PIK3CA
Pancreatic cancer	hsa05212	6.56	2	AKT1, PIK3CA
Epstein-Barr virus infection	hsa05169	4.97	2	AKT1, PIK3CA
Toxoplasmosis	hsa05145	5.71	2	PIK3CA, AKT1
Influenza A	hsa05164	5.21	2	AKT1, PIK3CA
Apoptosis	hsa04210	6.23	2	PIK3CA, AKT1
HTLV-I infection	hsa05166	4.59	2	PIK3CA, AKT1
Hepatitis C	hsa05160	5.68	2	AKT1, PIK3CA
Citrate cycle (TCA cycle)	hsa00020	7.86	2	SDHD, SDHB
VEGF signaling pathway	hsa04370	6.77	2	PIK3CA, AKT1
Proteoglycans in cancer	hsa05205	5.02	2	PIK3CA, AKT1
Estrogen signaling pathway	hsa04915	6.11	2	PIK3CA, AKT1
MicroRNAs in cancer	hsa05206	5.38	2	PIK3CA, PTEN
Toll-like receptor signaling pathway	hsa04620	6.0	2	PIK3CA, AKT1
Rap1 signaling pathway	hsa04015	4.97	2	AKT1, PIK3CA
T cell receptor signaling pathway	hsa04660	6.01	2	AKT1, PIK3CA
Phosphatidylinositol signaling system	hsa04070	6.38	2	PTEN, PIK3CA
B cell receptor signaling pathway	hsa04662	6.52	2	AKT1, PIK3CA
Ras signaling pathway	hsa04014	4.9	2	PIK3CA, AKT1
Non-small cell lung cancer	hsa05223	6.88	2	AKT1, PIK3CA
Prolactin signaling pathway	hsa04917	6.6	2	PIK3CA, AKT1
Acute myeloid leukemia	hsa05221	6.74	2	PIK3CA, AKT1
Chronic myeloid leukemia	hsa05220	6.48	2	AKT1, PIK3CA
TNF signaling pathway	hsa04668	5.96	2	PIK3CA, AKT1
Thyroid hormone signaling pathway	hsa04919	5.82	2	AKT1, PIK3CA
AMPK signaling pathway	hsa04152	5.8	2	AKT1, PIK3CA
Carbohydrate digestion and absorption	hsa04973	7.28	2	PIK3CA, AKT1
Oxidative phosphorylation	hsa00190	5.69	2	SDHD, SDHB
Metabolic pathways	hsa01100	2.49	2	SDHD, SDHB
Insulin signaling pathway	hsa04910	5.55	2	PIK3CA, AKT1
Carbon metabolism	hsa01200	6.03	2	SDHD, SDHB
Measles	hsa05162	5.6	2	PIK3CA, AKT1
Fc epsilon RI signaling pathway	hsa04664	6.6	2	AKT1, PIK3CA
Huntington's disease	hsa05016	5.17	2	SDHD, SDHB
Alzheimer's disease	hsa05010	5.34	2	SDHD, SDHB
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	2	AKT1, PIK3CA
Parkinson's disease	hsa05012	5.59	2	SDHD, SDHB
ErbB signaling pathway	hsa04012	6.15	2	PIK3CA, AKT1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Inositol phosphate metabolism (hsa00562)	-	6.72	0.006	AKT1, PIK3CA, PTEN
Melanoma (hsa05218)	-	6.56	0.011	AKT1, PTEN, PIK3CA
Citrate cycle (TCA cycle) (hsa00020)	-	7.86	0.045	SDHD, SDHB
Endocrine and metabolic diseases	NEW	4.75	0.003	SDHD, AKT1, SDHB, PTEN, PIK3CA
Oxidative phosphorylation (hsa00190)	-	5.69	0.02	SDHD, SDHB, AKT1
Energy metabolism	NEW	5.42	0.049	SDHD, SDHB, AKT1
Toll-like receptor signaling pathway (hsa04620)	-	6.0	0.041	AKT1, PTEN, PIK3CA
Carbohydrate metabolism	NEW	4.36	0.002	SDHD, AKT1, SDHB, PTEN, PIK3CA
Glioma (hsa05214)	-	6.66	0.006	AKT1, PIK3CA, PTEN
Prostate cancer (hsa05215)	-	6.11	0.007	AKT1, PTEN, PIK3CA
Endometrial cancer (hsa05213)	-	6.81	0.001	AKT1, PIK3CA, PTEN
Phosphatidylinositol signaling system (hsa04070)	-	6.38	0.019	AKT1, PTEN, PIK3CA
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.005	AKT1, PIK3CA, PTEN
Non-alcoholic fatty liver disease (NAFLD) (hsa04932)	-	5.51	0.0	SDHB, SDHD, AKT1, PIK3CA, PTEN
FoxO signaling pathway (hsa04068)	-	5.63	0.018	AKT1, PTEN, PIK3CA
Chronic myeloid leukemia (hsa05220)	-	6.48	0.01	AKT1, PIK3CA, PTEN
Hepatitis B (hsa05161)	-	5.52	0.022	AKT1, PTEN, PIK3CA
mTOR signaling pathway (hsa04150)	-	6.72	0.006	AKT1, PIK3CA, PTEN
Small cell lung cancer (hsa05222)	-	6.17	0.006	AKT1, PIK3CA, PTEN

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Metabolism	R-HSA-1430728	2.34	5	SDHB, SDHD, AKT1, PTEN, PIK3CA
PI3K/AKT activation	R-HSA-198203	6.32	3	AKT1, PIK3CA, PTEN
Immune System	R-HSA-168256	2.37	3	AKT1, PTEN, PIK3CA
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	3	AKT1, PTEN, PIK3CA
Downstream signal transduction	R-HSA-186763	4.65	3	AKT1, PTEN, PIK3CA
GAB1 signalosome	R-HSA-180292	6.31	3	AKT1, PTEN, PIK3CA
Signaling by ERBB4	R-HSA-1236394	4.7	3	AKT1, PIK3CA, PTEN
Adaptive Immune System	R-HSA-1280218	3.19	3	AKT1, PIK3CA, PTEN
Disease	R-HSA-1643685	3.33	3	AKT1, PIK3CA, PTEN
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95	3	AKT1, PTEN, PIK3CA
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	3	AKT1, PIK3CA, PTEN
PIP3 activates AKT signaling	R-HSA-1257604	6.37	3	AKT1, PTEN, PIK3CA
PI-3K cascade:FGFR4	R-HSA-5654720	6.37	3	AKT1, PIK3CA, PTEN
PI-3K cascade:FGFR1	R-HSA-5654689	6.37	3	AKT1, PTEN, PIK3CA
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	3	AKT1, PTEN, PIK3CA
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	3	AKT1, PIK3CA, PTEN
Signaling by FGFR4	R-HSA-5654743	4.69	3	AKT1, PTEN, PIK3CA
Signaling by FGFR3	R-HSA-5654741	4.69	3	AKT1, PIK3CA, PTEN
Signaling by FGFR	R-HSA-190236	4.67	3	AKT1, PIK3CA, PTEN
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56	3	AKT1, PTEN, PIK3CA
Diseases of signal transduction	R-HSA-5663202	4.89	3	AKT1, PTEN, PIK3CA
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	3	AKT1, PTEN, PIK3CA
Innate Immune System	R-HSA-168249	3.17	3	AKT1, PIK3CA, PTEN
Signaling by SCF-KIT	R-HSA-1433557	4.73	3	AKT1, PIK3CA, PTEN
Signaling by PDGF	R-HSA-186797	4.53	3	AKT1, PTEN, PIK3CA
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37	3	AKT1, PTEN, PIK3CA
PI-3K cascade:FGFR2	R-HSA-5654695	6.37	3	AKT1, PTEN, PIK3CA
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	3	AKT1, PTEN, PIK3CA
Signaling by EGFR	R-HSA-177929	4.59	3	AKT1, PTEN, PIK3CA
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	3	AKT1, PIK3CA, PTEN
Signalling by NGF	R-HSA-166520	4.23	3	AKT1, PTEN, PIK3CA
Signaling by FGFR2	R-HSA-5654738	4.68	3	AKT1, PIK3CA, PTEN
Signaling by FGFR1	R-HSA-5654736	4.69	3	AKT1, PTEN, PIK3CA
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37	3	AKT1, PTEN, PIK3CA
PI-3K cascade:FGFR3	R-HSA-5654710	6.37	3	AKT1, PIK3CA, PTEN
DAP12 interactions	R-HSA-2172127	4.56	3	AKT1, PIK3CA, PTEN
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	3	AKT1, PTEN, PIK3CA
Signaling by ERBB2	R-HSA-1227986	4.66	3	AKT1, PTEN, PIK3CA
Signal Transduction	R-HSA-162582	1.78	3	AKT1, PTEN, PIK3CA
DAP12 signaling	R-HSA-2424491	4.64	3	AKT1, PTEN, PIK3CA
Synthesis of PIPs at the plasma membrane	R-HSA-1660499	7.94	2	PTEN, PIK3CA
Transcriptional Regulation by TP53	R-HSA-3700989	6.73	2	AKT1, PTEN
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	2	PIK3CA, AKT1
The citric acid (TCA) cycle and respiratory electron transport	R-HSA-1428517	5.71	2	SDHD, SDHB
GPVI-mediated activation cascade	R-HSA-114604	7.18	2	AKT1, PIK3CA
IGF1R signaling cascade	R-HSA-2428924	4.85	2	PIK3CA, AKT1
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	2	AKT1, PIK3CA
PI Metabolism	R-HSA-1483255	7.31	2	PIK3CA, PTEN
Signaling by Insulin receptor	R-HSA-74752	4.73	2	AKT1, PIK3CA
Insulin receptor signalling cascade	R-HSA-74751	4.85	2	AKT1, PIK3CA
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.	R-HSA-163200	6.12	2	SDHD, SDHB
PI3K Cascade	R-HSA-109704	6.68	2	AKT1, PIK3CA
Signaling by VEGF	R-HSA-194138	4.66	2	PIK3CA, AKT1
Gene Expression	R-HSA-74160	2.72	2	PTEN, AKT1
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	2	PIK3CA, AKT1
Phospholipid metabolism	R-HSA-1483257	5.83	2	PTEN, PIK3CA
IRS-mediated signalling	R-HSA-112399	4.87	2	AKT1, PIK3CA
Negative regulation of the PI3K/AKT network	R-HSA-199418	9.98	2	AKT1, PTEN
CD28 co-stimulation	R-HSA-389356	7.98	2	PIK3CA, AKT1
CD28 dependent PI3K/Akt signaling	R-HSA-389357	8.59	2	AKT1, PIK3CA
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	2	PIK3CA, PTEN
TP53 Regulates Metabolic Genes	R-HSA-5628897	6.73	2	AKT1, PTEN
TCR signaling	R-HSA-202403	6.64	2	PTEN, PIK3CA
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	2	PIK3CA, AKT1
Respiratory electron transport	R-HSA-611105	6.44	2	SDHD, SDHB
Pyruvate metabolism and Citric Acid (TCA) cycle	R-HSA-71406	7.56	2	SDHD, SDHB
Downstream TCR signaling	R-HSA-202424	7.01	2	PTEN, PIK3CA
Citric acid cycle (TCA cycle)	R-HSA-71403	8.73	2	SDHD, SDHB
GPCR downstream signaling	R-HSA-388396	3.07	2	PIK3CA, AKT1
G beta:gamma signalling through PI3Kgamma	R-HSA-392451	7.4	2	AKT1, PIK3CA
Costimulation by the CD28 family	R-HSA-388841	6.56	2	PIK3CA, AKT1
Signaling by GPCR	R-HSA-372790	2.68	2	PIK3CA, AKT1
G-protein beta:gamma signalling	R-HSA-397795	7.31	2	AKT1, PIK3CA
Generic Transcription Pathway	R-HSA-212436	3.86	2	AKT1, PTEN
Hemostasis	R-HSA-109582	3.98	2	PIK3CA, AKT1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Synthesis of PIPs at the plasma membrane (R-HSA-1660499)	-	7.94	0.022	AKT1, PIK3CA, PTEN
PI3K/AKT activation (R-HSA-198203)	-	6.32	0.003	AKT1, PIK3CA, PTEN
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)	NEW	7.05	0.006	AKT1, PIK3CA, PTEN
PI3K events in ERBB2 signaling (R-HSA-1963642)	-	6.37	0.04	AKT1, PTEN, PIK3CA
Metabolism (R-HSA-1430728)	-	2.34	0.042	SDHB, SDHD, AKT1, PIK3CA, PTEN
GAB1 signalosome (R-HSA-180292)	-	6.31	0.048	AKT1, PIK3CA, PTEN
Role of LAT2/NTAL/LAB on calcium mobilization (R-HSA-2730905)	-	4.95	0.044	AKT1, PIK3CA, PTEN
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200)	-	6.12	0.024	SDHD, SDHB, AKT1
Citric acid cycle (TCA cycle) (R-HSA-71403)	-	8.73	0.021	SDHD, SDHB
PIP3 activates AKT signaling (R-HSA-1257604)	-	6.37	0.04	AKT1, PTEN, PIK3CA
PI-3K cascade:FGFR3 (R-HSA-5654710)	-	6.37	0.04	AKT1, PTEN, PIK3CA
PI-3K cascade:FGFR4 (R-HSA-5654720)	-	6.37	0.04	AKT1, PTEN, PIK3CA
PI-3K cascade:FGFR1 (R-HSA-5654689)	-	6.37	0.002	AKT1, PIK3CA, PTEN
CTLA4 inhibitory signaling (R-HSA-389513)	NEW	8.52	0.049	PTEN, AKT1
PI Metabolism (R-HSA-1483255)	-	7.31	0.003	AKT1, PIK3CA, PTEN
Negative regulation of the PI3K/AKT network (R-HSA-199418)	-	9.98	0.001	AKT1, PTEN
CD28 co-stimulation (R-HSA-389356)	-	7.98	0.0	AKT1, PTEN, PIK3CA
Downstream signaling events of B Cell Receptor (BCR) (R-HSA-1168372)	-	5.59	0.012	AKT1, PTEN, PIK3CA
Costimulation by the CD28 family (R-HSA-388841)	-	6.56	0.021	AKT1, PTEN, PIK3CA
TCR signaling (R-HSA-202403)	-	6.64	0.014	AKT1, PIK3CA, PTEN
Pyruvate metabolism and Citric Acid (TCA) cycle (R-HSA-71406)	-	7.56	0.038	SDHD, SDHB
Downstream TCR signaling (R-HSA-202424)	-	7.01	0.004	AKT1, PTEN, PIK3CA
PI3K/AKT Signaling in Cancer (R-HSA-2219528)	-	6.56	0.025	AKT1, PTEN, PIK3CA
Diseases of signal transduction (R-HSA-5663202)	-	4.89	0.05	AKT1, PTEN, PIK3CA
CD28 dependent PI3K/Akt signaling (R-HSA-389357)	-	8.59	0.0	AKT1, PTEN, PIK3CA
G beta:gamma signalling through PI3Kgamma (R-HSA-392451)	-	7.4	0.047	AKT1, PIK3CA
PI-3K cascade:FGFR2 (R-HSA-5654695)	-	6.37	0.002	AKT1, PIK3CA, PTEN
Class B/2 (Secretin family receptors) (R-HSA-373080)	NEW	6.52	0.032	AKT1, PTEN, PIK3CA
PI3K events in ERBB4 signaling (R-HSA-1250342)	-	6.37	0.002	AKT1, PTEN, PIK3CA
PI3K Cascade (R-HSA-109704)	-	6.68	0.021	AKT1, PTEN, PIK3CA

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	7	PTEN, KLLN, SEC23B, PIK3CA, SDHB, SDHD, AKT1
catalytic activity (GO:0003824)	1.05	5	SDHB, SDHD, AKT1, PTEN, PIK3CA
protein binding (GO:0005515)	0.46	5	SDHB, SEC23B, AKT1, PIK3CA, PTEN
ion binding (GO:0043167)	1.36	5	AKT1, SDHD, SEC23B, SDHB, PTEN
organic cyclic compound binding (GO:0097159)	1.05	4	SDHD, AKT1, KLLN, PIK3CA
metal ion binding (GO:0046872)	1.41	4	SDHD, SEC23B, SDHB, PTEN
heterocyclic compound binding (GO:1901363)	1.06	4	SDHD, KLLN, AKT1, PIK3CA
cation binding (GO:0043169)	1.4	4	SDHD, SEC23B, SDHB, PTEN
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	2	PIK3CA, AKT1
enzyme binding (GO:0019899)	2.27	2	PTEN, AKT1
protein kinase activity (GO:0004672)	3.27	2	AKT1, PIK3CA
molecular function regulator (GO:0098772)	2.51	2	PIK3CA, AKT1
nucleoside phosphate binding (GO:1901265)	1.96	2	PIK3CA, AKT1
oxidoreductase activity (GO:0016491)	3.12	2	SDHD, SDHB
succinate dehydrogenase activity (GO:0000104)	8.13	2	SDHD, SDHB
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627)	5.66	2	SDHD, SDHB
nucleotide binding (GO:0000166)	1.96	2	AKT1, PIK3CA
protein serine/threonine kinase activity (GO:0004674)	3.64	2	AKT1, PIK3CA
transferase activity (GO:0016740)	1.95	2	PIK3CA, AKT1
purine nucleoside binding (GO:0001883)	2.22	2	PIK3CA, AKT1
ribonucleoside binding (GO:0032549)	2.22	2	AKT1, PIK3CA
purine nucleotide binding (GO:0017076)	2.19	2	PIK3CA, AKT1
nucleoside binding (GO:0001882)	2.21	2	AKT1, PIK3CA
ATP binding (GO:0005524)	2.43	2	PIK3CA, AKT1
enzyme regulator activity (GO:0030234)	2.85	2	PIK3CA, AKT1
kinase activity (GO:0016301)	2.93	2	AKT1, PIK3CA
lipid binding (GO:0008289)	3.26	2	PTEN, AKT1
small molecule binding (GO:0036094)	1.89	2	AKT1, PIK3CA
kinase binding (GO:0019900)	3.32	2	PTEN, AKT1
cofactor binding (GO:0048037)	4.16	2	SDHD, SDHB
ubiquinone binding (GO:0048039)	8.35	2	SDHD, SDHB
quinone binding (GO:0048038)	6.91	2	SDHD, SDHB
electron carrier activity (GO:0009055)	4.97	2	SDHD, SDHB
protein kinase binding (GO:0019901)	3.44	2	AKT1, PTEN
adenyl nucleotide binding (GO:0030554)	2.4	2	PIK3CA, AKT1
carbohydrate derivative binding (GO:0097367)	2.03	2	AKT1, PIK3CA
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	2	AKT1, PIK3CA
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	2	AKT1, PIK3CA
adenyl ribonucleotide binding (GO:0032559)	2.41	2	PIK3CA, AKT1
identical protein binding (GO:0042802)	2.63	2	PTEN, AKT1
purine ribonucleotide binding (GO:0032555)	2.2	2	PIK3CA, AKT1
purine ribonucleoside binding (GO:0032550)	2.22	2	AKT1, PIK3CA
ribonucleotide binding (GO:0032553)	2.19	2	PIK3CA, AKT1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
phosphatidylinositol phosphate phosphatase activity (GO:0052866)	NEW	6.34	0.028	AKT1, PTEN
succinate dehydrogenase activity (GO:0000104)	-	8.13	0.0	SDHD, SDHB
cytoskeletal adaptor activity (GO:0008093)	NEW	6.97	0.049	AKT1, PTEN
cytokine receptor activity (GO:0004896)	NEW	5.24	0.028	AKT1, PTEN, PIK3CA
lipoprotein particle receptor binding (GO:0070325)	NEW	6.65	0.035	AKT1, PIK3CA
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627)	-	5.66	0.004	SDHD, SDHB, AKT1
cytokine binding (GO:0019955)	NEW	5.21	0.027	AKT1, PIK3CA, PTEN
kinase activator activity (GO:0019209)	NEW	5.58	0.008	AKT1, PTEN, PIK3CA
phosphatidylinositol phosphate kinase activity (GO:0016307)	NEW	6.97	0.016	AKT1, PIK3CA
phosphatase regulator activity (GO:0019208)	NEW	5.26	0.011	AKT1, PIK3CA, PTEN
inositol phosphate phosphatase activity (GO:0052745)	NEW	6.74	0.018	AKT1, PTEN
lipid kinase activity (GO:0001727)	NEW	7.95	0.003	AKT1, PIK3CA
cargo receptor activity (GO:0038024)	NEW	5.53	0.02	AKT1, PIK3CA, PTEN
phosphatidylinositol trisphosphate phosphatase activity (GO:0034594)	NEW	7.79	0.005	AKT1, PTEN
inositol tetrakisphosphate phosphatase activity (GO:0052743)	NEW	7.34	0.002	AKT1, PTEN
ubiquinone binding (GO:0048039)	-	8.35	0.0	SDHD, SDHB
quinone binding (GO:0048038)	-	6.91	0.002	SDHD, SDHB
protein kinase activator activity (GO:0030295)	NEW	5.68	0.006	AKT1, PTEN, PIK3CA
electron carrier activity (GO:0009055)	-	4.97	0.027	SDHD, SDHB, AKT1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	6	PTEN, KLLN, PIK3CA, SDHB, SDHD, AKT1
single-organism cellular process (GO:0044763)	0.65	6	PTEN, KLLN, PIK3CA, SDHB, SDHD, AKT1
single-organism process (GO:0044699)	0.48	6	AKT1, KLLN, PIK3CA, PTEN, SDHB, SDHD
primary metabolic process (GO:0044238)	0.69	5	SDHD, AKT1, SDHB, PTEN, PIK3CA
single-organism metabolic process (GO:0044710)	1.63	5	SDHD, PTEN, AKT1, SDHB, PIK3CA
cellular metabolic process (GO:0044237)	0.69	5	SDHB, SDHD, AKT1, PTEN, PIK3CA
organic substance metabolic process (GO:0071704)	0.63	5	SDHD, PTEN, AKT1, SDHB, PIK3CA
small molecule metabolic process (GO:0044281)	2.38	5	SDHB, SDHD, AKT1, PTEN, PIK3CA
metabolic process (GO:0008152)	0.58	5	SDHD, AKT1, SDHB, PTEN, PIK3CA
negative regulation of biological process (GO:0048519)	1.33	4	PTEN, KLLN, AKT1, PIK3CA
biological regulation (GO:0065007)	0.39	4	PTEN, AKT1, KLLN, PIK3CA
regulation of biological process (GO:0050789)	0.45	4	PIK3CA, AKT1, PTEN, KLLN
negative regulation of cellular process (GO:0048523)	1.41	4	PTEN, KLLN, AKT1, PIK3CA
regulation of cellular process (GO:0050794)	0.5	4	AKT1, KLLN, PTEN, PIK3CA
regulation of phosphate metabolic process (GO:0019220)	2.35	3	AKT1, PTEN, PIK3CA
regulation of primary metabolic process (GO:0080090)	1.08	3	PTEN, PIK3CA, AKT1
regulation of metabolic process (GO:0019222)	1.02	3	PTEN, PIK3CA, AKT1
positive regulation of response to stimulus (GO:0048584)	2.18	3	AKT1, PTEN, PIK3CA
regulation of response to stimulus (GO:0048583)	1.54	3	AKT1, PTEN, PIK3CA
signal transduction (GO:0007165)	1.28	3	PTEN, PIK3CA, AKT1
cell surface receptor signaling pathway (GO:0007166)	2.09	3	AKT1, PTEN, PIK3CA
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	3	PTEN, PIK3CA, AKT1
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	3	PTEN, AKT1, PIK3CA
cellular component organization or biogenesis (GO:0071840)	1.22	3	AKT1, PTEN, PIK3CA
cellular response to stimulus (GO:0051716)	1.97	3	AKT1, PTEN, PIK3CA
single-organism biosynthetic process (GO:0044711)	2.8	3	PTEN, PIK3CA, AKT1
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	3	AKT1, PTEN, PIK3CA
regulation of signal transduction (GO:0009966)	1.84	3	AKT1, PTEN, PIK3CA
animal organ development (GO:0048513)	2.53	3	PTEN, AKT1, PIK3CA
positive regulation of molecular function (GO:0044093)	2.23	3	AKT1, PTEN, PIK3CA
positive regulation of biological process (GO:0048518)	1.2	3	PTEN, PIK3CA, AKT1
regulation of macromolecule metabolic process (GO:0060255)	1.08	3	AKT1, PTEN, PIK3CA
negative regulation of cell death (GO:0060548)	2.95	3	PTEN, AKT1, PIK3CA
regulation of protein kinase activity (GO:0045859)	3.15	3	AKT1, PTEN, PIK3CA
response to organic substance (GO:0010033)	2.2	3	PTEN, AKT1, PIK3CA
oxidation-reduction process (GO:0055114)	2.91	3	SDHD, SDHB, AKT1
system process (GO:0003008)	2.3	3	PTEN, AKT1, PIK3CA
regulation of phosphorylation (GO:0042325)	2.5	3	PTEN, PIK3CA, AKT1
positive regulation of phosphorylation (GO:0042327)	2.9	3	AKT1, PTEN, PIK3CA
single-multicellular organism process (GO:0044707)	1.78	3	PTEN, AKT1, PIK3CA
protein metabolic process (GO:0019538)	1.45	3	PTEN, AKT1, PIK3CA
immune system process (GO:0002376)	2.29	3	AKT1, PTEN, PIK3CA
positive regulation of metabolic process (GO:0009893)	1.74	3	AKT1, PTEN, PIK3CA
intracellular signal transduction (GO:0035556)	2.39	3	PTEN, PIK3CA, AKT1
regulation of apoptotic process (GO:0042981)	2.5	3	PTEN, PIK3CA, AKT1
cellular protein metabolic process (GO:0044267)	1.63	3	PTEN, AKT1, PIK3CA
positive regulation of transferase activity (GO:0051347)	3.31	3	AKT1, PTEN, PIK3CA
cellular macromolecule metabolic process (GO:0044260)	0.93	3	PTEN, PIK3CA, AKT1
regulation of kinase activity (GO:0043549)	3.07	3	PTEN, PIK3CA, AKT1
cellular component organization (GO:0016043)	1.24	3	PTEN, AKT1, PIK3CA
positive regulation of immune system process (GO:0002684)	2.96	3	PTEN, PIK3CA, AKT1
regulation of immune system process (GO:0002682)	2.5	3	AKT1, PTEN, PIK3CA
regulation of molecular function (GO:0065009)	1.78	3	PTEN, PIK3CA, AKT1
regulation of biological quality (GO:0065008)	1.68	3	AKT1, PTEN, PIK3CA
regulation of catalytic activity (GO:0050790)	1.97	3	AKT1, PTEN, PIK3CA
regulation of developmental process (GO:0050793)	2.1	3	AKT1, PTEN, PIK3CA
transport (GO:0006810)	1.51	3	SEC23B, AKT1, PIK3CA
programmed cell death (GO:0012501)	3.1	3	PTEN, KLLN, AKT1
macromolecule modification (GO:0043412)	1.73	3	AKT1, PTEN, PIK3CA
protein modification process (GO:0036211)	1.79	3	PTEN, AKT1, PIK3CA
regulation of multicellular organismal process (GO:0051239)	1.87	3	AKT1, PTEN, PIK3CA
single-organism carbohydrate metabolic process (GO:0044723)	3.42	3	PTEN, PIK3CA, AKT1
establishment of localization (GO:0051234)	1.48	3	SEC23B, AKT1, PIK3CA
phosphatidylinositol-mediated signaling (GO:0048015)	4.93	3	AKT1, PTEN, PIK3CA
inositol lipid-mediated signaling (GO:0048017)	4.91	3	AKT1, PTEN, PIK3CA
single-organism developmental process (GO:0044767)	1.49	3	AKT1, PTEN, PIK3CA
protein kinase B signaling (GO:0043491)	6.2	3	PTEN, AKT1, PIK3CA
response to stimulus (GO:0050896)	1.22	3	AKT1, PTEN, PIK3CA
positive regulation of protein modification process (GO:0031401)	2.7	3	AKT1, PTEN, PIK3CA
regulation of transferase activity (GO:0051338)	2.88	3	AKT1, PTEN, PIK3CA
regulation of cell adhesion (GO:0030155)	3.27	3	PTEN, AKT1, PIK3CA
cellular biosynthetic process (GO:0044249)	1.37	3	PTEN, PIK3CA, AKT1
cellular response to chemical stimulus (GO:0070887)	2.57	3	PTEN, AKT1, PIK3CA
regulation of signaling (GO:0023051)	1.72	3	PTEN, PIK3CA, AKT1
regulation of cell communication (GO:0010646)	1.73	3	AKT1, PTEN, PIK3CA
positive regulation of catalytic activity (GO:0043085)	2.4	3	PTEN, PIK3CA, AKT1
regulation of intracellular signal transduction (GO:1902531)	2.31	3	AKT1, PTEN, PIK3CA
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	3	AKT1, PTEN, PIK3CA
regulation of protein metabolic process (GO:0051246)	1.93	3	AKT1, PTEN, PIK3CA
positive regulation of protein metabolic process (GO:0051247)	2.43	3	PTEN, AKT1, PIK3CA
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	3	AKT1, PTEN, PIK3CA
regulation of protein modification process (GO:0031399)	2.32	3	AKT1, PTEN, PIK3CA
developmental process (GO:0032502)	1.36	3	PTEN, AKT1, PIK3CA
organelle organization (GO:0006996)	2.02	3	PTEN, AKT1, PIK3CA
multicellular organismal process (GO:0032501)	1.45	3	AKT1, PTEN, PIK3CA
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)	4.79	3	PTEN, AKT1, PIK3CA
regulation of cellular protein metabolic process (GO:0032268)	1.99	3	PTEN, AKT1, PIK3CA
macromolecule metabolic process (GO:0043170)	0.83	3	AKT1, PTEN, PIK3CA
system development (GO:0048731)	2.92	3	AKT1, PTEN, PIK3CA
positive regulation of cellular metabolic process (GO:0031325)	1.81	3	PTEN, PIK3CA, AKT1
regulation of cellular metabolic process (GO:0031323)	1.07	3	PTEN, PIK3CA, AKT1
cell death (GO:0008219)	3.05	3	PTEN, KLLN, AKT1
regulation of cell death (GO:0010941)	2.43	3	AKT1, PTEN, PIK3CA
regulation of growth (GO:0040008)	3.26	3	AKT1, PTEN, PIK3CA
regulation of programmed cell death (GO:0043067)	2.49	3	PTEN, PIK3CA, AKT1
negative regulation of apoptotic process (GO:0043066)	3.04	3	AKT1, PTEN, PIK3CA
negative regulation of programmed cell death (GO:0043069)	3.02	3	PTEN, PIK3CA, AKT1
regulation of gene expression (GO:0010468)	1.37	3	AKT1, PTEN, PIK3CA
positive regulation of phosphate metabolic process (GO:0045937)	2.78	3	PTEN, AKT1, PIK3CA
organic substance biosynthetic process (GO:1901576)	1.34	3	AKT1, PTEN, PIK3CA
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	3	AKT1, PTEN, PIK3CA
apoptotic process (GO:0006915)	3.14	3	AKT1, KLLN, PTEN
cellular protein modification process (GO:0006464)	1.79	3	AKT1, PTEN, PIK3CA
regulation of phosphorus metabolic process (GO:0051174)	2.35	3	AKT1, PTEN, PIK3CA
biosynthetic process (GO:0009058)	1.32	3	AKT1, PTEN, PIK3CA
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	3	PTEN, PIK3CA, AKT1
response to chemical (GO:0042221)	1.98	3	PTEN, PIK3CA, AKT1
localization (GO:0051179)	1.4	3	SEC23B, AKT1, PIK3CA
response to oxygen-containing compound (GO:1901700)	2.57	3	PTEN, PIK3CA, AKT1
carbohydrate metabolic process (GO:0005975)	3.26	3	AKT1, PTEN, PIK3CA
regulation of cell cycle (GO:0051726)	2.93	3	AKT1, KLLN, PTEN
anatomical structure development (GO:0048856)	1.58	3	AKT1, PTEN, PIK3CA
phosphate-containing compound metabolic process (GO:0006796)	2.16	3	AKT1, PTEN, PIK3CA
phosphorus metabolic process (GO:0006793)	2.15	3	AKT1, PTEN, PIK3CA
regulation of protein phosphorylation (GO:0001932)	2.57	3	AKT1, PTEN, PIK3CA
positive regulation of protein phosphorylation (GO:0001934)	2.95	3	PTEN, AKT1, PIK3CA
positive regulation of cellular process (GO:0048522)	1.3	3	AKT1, PTEN, PIK3CA
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	4.69	2	AKT1, PTEN
protein localization (GO:0008104)	2.36	2	SEC23B, AKT1
regulation of apoptotic signaling pathway (GO:2001233)	3.83	2	AKT1, PTEN
regulation of transport (GO:0051049)	2.24	2	AKT1, PTEN
negative regulation of response to stimulus (GO:0048585)	2.52	2	PTEN, AKT1
membrane organization (GO:0061024)	3.04	2	AKT1, PTEN
plasma membrane organization (GO:0007009)	4.8	2	PTEN, AKT1
regulation of anatomical structure size (GO:0090066)	3.78	2	PTEN, AKT1
regulation of cell projection organization (GO:0031344)	3.38	2	AKT1, PTEN
mitochondrion organization (GO:0007005)	3.69	2	PIK3CA, AKT1
negative regulation of cell communication (GO:0010648)	2.66	2	AKT1, PTEN
negative regulation of cell cycle (GO:0045786)	3.67	2	KLLN, PTEN
negative regulation of signal transduction (GO:0009968)	2.75	2	PTEN, AKT1
positive regulation of cell adhesion (GO:0045785)	3.79	2	PIK3CA, AKT1
positive regulation of signal transduction (GO:0009967)	2.5	2	AKT1, PTEN
negative regulation of kinase activity (GO:0033673)	4.22	2	PTEN, AKT1
regulation of neuron differentiation (GO:0045664)	3.39	2	AKT1, PTEN
negative regulation of molecular function (GO:0044092)	2.74	2	PTEN, AKT1
phosphatidylinositol biosynthetic process (GO:0006661)	4.94	2	PTEN, PIK3CA
macromolecule localization (GO:0033036)	2.34	2	SEC23B, AKT1
T cell costimulation (GO:0031295)	5.35	2	AKT1, PIK3CA
lymphocyte costimulation (GO:0031294)	5.33	2	AKT1, PIK3CA
regulation of cell proliferation (GO:0042127)	2.41	2	AKT1, PTEN
regulation of DNA metabolic process (GO:0051052)	3.87	2	PIK3CA, AKT1
negative regulation of transport (GO:0051051)	3.6	2	AKT1, PTEN
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	2	AKT1, PTEN
establishment of protein localization (GO:0045184)	2.53	2	SEC23B, AKT1
developmental process involved in reproduction (GO:0003006)	3.36	2	AKT1, PTEN
regulation of cell size (GO:0008361)	5.42	2	AKT1, PTEN
negative regulation of cell size (GO:0045792)	7.53	2	PTEN, AKT1
phosphatidylinositol metabolic process (GO:0046488)	4.46	2	PTEN, PIK3CA
regulation of neuron projection development (GO:0010975)	3.69	2	PTEN, AKT1
regulation of RNA biosynthetic process (GO:2001141)	1.55	2	PTEN, AKT1
aging (GO:0007568)	4.16	2	PTEN, AKT1
glycerolipid metabolic process (GO:0046486)	3.91	2	PTEN, PIK3CA
response to abiotic stimulus (GO:0009628)	2.8	2	AKT1, PTEN
platelet activation (GO:0030168)	4.96	2	AKT1, PIK3CA
vesicle-mediated transport (GO:0016192)	2.72	2	SEC23B, PIK3CA
immune response-activating cell surface receptor signaling pathway (GO:0002429)	4.06	2	PIK3CA, PTEN
epithelial cell migration (GO:0010631)	5.42	2	PTEN, PIK3CA
response to external stimulus (GO:0009605)	2.55	2	PTEN, AKT1
response to monosaccharide (GO:0034284)	4.77	2	PTEN, PIK3CA
response to organonitrogen compound (GO:0010243)	3.2	2	AKT1, PTEN
cell motility (GO:0048870)	3.02	2	PIK3CA, PTEN
response to nutrient levels (GO:0031667)	3.77	2	PTEN, AKT1
chemical homeostasis (GO:0048878)	2.97	2	PIK3CA, AKT1
cellular response to stress (GO:0033554)	2.51	2	AKT1, PTEN
organophosphate metabolic process (GO:0019637)	3.04	2	PIK3CA, PTEN
regulation of cyclin-dependent protein kinase activity (GO:1904029)	5.21	2	AKT1, PTEN
regulation of cellular component size (GO:0032535)	4.21	2	PTEN, AKT1
regulation of mitotic cell cycle phase transition (GO:1901990)	4.23	2	PTEN, AKT1
positive regulation of catabolic process (GO:0009896)	3.94	2	AKT1, PTEN
regulation of catabolic process (GO:0009894)	3.52	2	PTEN, AKT1
negative regulation of metabolic process (GO:0009892)	1.93	2	PTEN, AKT1
positive regulation of kinase activity (GO:0033674)	3.54	2	PIK3CA, AKT1
positive regulation of cell communication (GO:0010647)	2.41	2	PTEN, AKT1
T cell receptor signaling pathway (GO:0050852)	4.71	2	PIK3CA, PTEN
movement of cell or subcellular component (GO:0006928)	2.61	2	PTEN, PIK3CA
regulation of cell migration (GO:0030334)	3.23	2	PTEN, AKT1
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	2	AKT1, PTEN
ERBB2 signaling pathway (GO:0038128)	6.09	2	AKT1, PIK3CA
endothelial cell migration (GO:0043542)	5.69	2	PIK3CA, PTEN
regulation of mitotic cell cycle (GO:0007346)	3.71	2	AKT1, PTEN
cellular carbohydrate metabolic process (GO:0044262)	4.74	2	PTEN, AKT1
immune response-regulating signaling pathway (GO:0002764)	3.72	2	PIK3CA, PTEN
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	3.96	2	PTEN, PIK3CA
intracellular protein transport (GO:0006886)	3.2	2	SEC23B, AKT1
negative regulation of transferase activity (GO:0051348)	3.87	2	PTEN, AKT1
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114)	3.79	2	AKT1, PTEN
cellular response to oxygen levels (GO:0071453)	4.97	2	AKT1, PTEN
negative regulation of MAPK cascade (GO:0043409)	4.74	2	PTEN, AKT1
cellular response to hypoxia (GO:0071456)	5.11	2	AKT1, PTEN
cell migration (GO:0016477)	3.12	2	PIK3CA, PTEN
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	2	PTEN, PIK3CA
single organism reproductive process (GO:0044702)	2.73	2	AKT1, PTEN
lipid metabolic process (GO:0006629)	2.68	2	PTEN, PIK3CA
hexose metabolic process (GO:0019318)	4.64	2	PIK3CA, AKT1
regulation of biosynthetic process (GO:0009889)	1.37	2	AKT1, PTEN
tissue development (GO:0009888)	3.27	2	PTEN, PIK3CA
regulation of cell cycle phase transition (GO:1901987)	4.15	2	AKT1, PTEN
cell activation (GO:0001775)	3.47	2	AKT1, PIK3CA
regulation of lymphocyte activation (GO:0051249)	3.73	2	AKT1, PIK3CA
single-organism membrane organization (GO:0044802)	3.19	2	AKT1, PTEN
positive regulation of proteolysis (GO:0045862)	3.86	2	AKT1, PTEN
negative regulation of intracellular signal transduction (GO:1902532)	3.63	2	AKT1, PTEN
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	2	AKT1, PTEN
regulation of neuron death (GO:1901214)	4.19	2	PIK3CA, AKT1
negative regulation of neuron death (GO:1901215)	4.57	2	PIK3CA, AKT1
organophosphate biosynthetic process (GO:0090407)	3.67	2	PIK3CA, PTEN
immune response-activating signal transduction (GO:0002757)	3.8	2	PIK3CA, PTEN
energy derivation by oxidation of organic compounds (GO:0015980)	4.93	2	SDHB, AKT1
intracellular transport (GO:0046907)	2.67	2	SEC23B, AKT1
phospholipid biosynthetic process (GO:0008654)	4.39	2	PTEN, PIK3CA
response to decreased oxygen levels (GO:0036293)	4.09	2	PTEN, AKT1
regulation of response to stress (GO:0080134)	2.53	2	AKT1, PTEN
regulation of cellular response to stress (GO:0080135)	3.4	2	PTEN, AKT1
response to stress (GO:0006950)	1.8	2	AKT1, PTEN
cellular response to decreased oxygen levels (GO:0036294)	5.05	2	AKT1, PTEN
regulation of leukocyte activation (GO:0002694)	3.6	2	PIK3CA, AKT1
positive regulation of leukocyte activation (GO:0002696)	4.0	2	PIK3CA, AKT1
regulation of cell motility (GO:2000145)	3.16	2	PTEN, AKT1
cellular developmental process (GO:0048869)	1.82	2	PTEN, AKT1
regulation of developmental growth (GO:0048638)	4.04	2	PIK3CA, PTEN
phosphorylation (GO:0016310)	2.63	2	AKT1, PIK3CA
negative regulation of cellular component organization (GO:0051129)	3.35	2	AKT1, PTEN
regulation of cellular component organization (GO:0051128)	2.01	2	AKT1, PTEN
positive regulation of signaling (GO:0023056)	2.41	2	AKT1, PTEN
negative regulation of signaling (GO:0023057)	2.65	2	AKT1, PTEN
regulation of protein catabolic process (GO:0042176)	3.83	2	AKT1, PTEN
ERBB signaling pathway (GO:0038127)	5.36	2	AKT1, PIK3CA
regulation of nervous system development (GO:0051960)	3.1	2	PTEN, AKT1
ameboidal-type cell migration (GO:0001667)	4.71	2	PTEN, PIK3CA
response to hypoxia (GO:0001666)	4.13	2	AKT1, PTEN
negative regulation of catalytic activity (GO:0043086)	3.0	2	AKT1, PTEN
response to organic cyclic compound (GO:0014070)	3.07	2	PTEN, AKT1
regulation of MAPK cascade (GO:0043408)	3.22	2	AKT1, PTEN
response to endogenous stimulus (GO:0009719)	2.79	2	PTEN, AKT1
regulation of neurogenesis (GO:0050767)	3.21	2	AKT1, PTEN
negative regulation of protein metabolic process (GO:0051248)	2.82	2	PTEN, AKT1
negative regulation of phosphorylation (GO:0042326)	3.7	2	PTEN, AKT1
regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle (GO:0031657)	7.53	2	PTEN, AKT1
regulation of cellular catabolic process (GO:0031329)	3.83	2	PTEN, AKT1
regulation of system process (GO:0044057)	3.53	2	AKT1, PTEN
response to nitrogen compound (GO:1901698)	3.12	2	AKT1, PTEN
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	2	PTEN, AKT1
regulation of cell cycle process (GO:0010564)	3.5	2	AKT1, PTEN
regulation of cell development (GO:0060284)	3.01	2	AKT1, PTEN
positive regulation of leukocyte cell-cell adhesion (GO:1903039)	4.35	2	AKT1, PIK3CA
regulation of cellular biosynthetic process (GO:0031326)	1.38	2	PTEN, AKT1
cellular localization (GO:0051641)	2.32	2	SEC23B, AKT1
regulation of leukocyte cell-cell adhesion (GO:1903037)	4.01	2	AKT1, PIK3CA
positive regulation of cell proliferation (GO:0008284)	3.01	2	AKT1, PTEN
response to hexose (GO:0009746)	4.82	2	PIK3CA, PTEN
insulin receptor signaling pathway (GO:0008286)	5.33	2	PIK3CA, AKT1
multicellular organismal reproductive process (GO:0048609)	3.35	2	AKT1, PTEN
lipid biosynthetic process (GO:0008610)	3.49	2	PTEN, PIK3CA
cell proliferation (GO:0008283)	3.23	2	PTEN, AKT1
positive regulation of proteolysis involved in cellular protein catabolic process (GO:1903052)	4.6	2	PTEN, AKT1
positive regulation of cellular catabolic process (GO:0031331)	4.15	2	AKT1, PTEN
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050)	4.32	2	PTEN, AKT1
regulation of immune response (GO:0050776)	2.98	2	PTEN, PIK3CA
positive regulation of T cell activation (GO:0050870)	4.39	2	AKT1, PIK3CA
regulation of cell differentiation (GO:0045595)	2.42	2	PTEN, AKT1
regulation of locomotion (GO:0040012)	3.12	2	AKT1, PTEN
cellular lipid metabolic process (GO:0044255)	2.92	2	PTEN, PIK3CA
regulation of localization (GO:0032879)	1.94	2	PTEN, AKT1
lipid modification (GO:0030258)	4.37	2	PIK3CA, PTEN
myelin maintenance (GO:0043217)	7.24	2	AKT1, PTEN
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	2	AKT1, PTEN
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	2	AKT1, PTEN
regulation of epithelial cell proliferation (GO:0050678)	4.06	2	PTEN, AKT1
regulation of G1/S transition of mitotic cell cycle (GO:2000045)	4.81	2	PTEN, AKT1
organic acid metabolic process (GO:0006082)	3.01	2	SDHD, SDHB
regulation of cell-cell adhesion (GO:0022407)	3.79	2	AKT1, PIK3CA
positive regulation of lymphocyte activation (GO:0051251)	4.07	2	AKT1, PIK3CA
monosaccharide metabolic process (GO:0005996)	4.57	2	AKT1, PIK3CA
regulation of RNA metabolic process (GO:0051252)	1.52	2	PTEN, AKT1
positive regulation of immune response (GO:0050778)	3.4	2	PIK3CA, PTEN
glycerophospholipid biosynthetic process (GO:0046474)	4.62	2	PTEN, PIK3CA
glucose metabolic process (GO:0006006)	4.94	2	PIK3CA, AKT1
positive regulation of protein catabolic process (GO:0045732)	4.18	2	AKT1, PTEN
negative regulation of protein modification process (GO:0031400)	3.4	2	AKT1, PTEN
response to extracellular stimulus (GO:0009991)	3.71	2	PTEN, AKT1
positive regulation of peptidyl-serine phosphorylation (GO:0033138)	5.26	2	PIK3CA, AKT1
glycerophospholipid metabolic process (GO:0006650)	4.13	2	PTEN, PIK3CA
regulation of cellular localization (GO:0060341)	3.03	2	PTEN, AKT1
cell projection organization (GO:0030030)	3.14	2	AKT1, PTEN
regulation of peptidyl-serine phosphorylation (GO:0033135)	4.98	2	AKT1, PIK3CA
positive regulation of cell activation (GO:0050867)	3.97	2	PIK3CA, AKT1
negative regulation of cellular metabolic process (GO:0031324)	2.01	2	PTEN, AKT1
regulation of cell activation (GO:0050865)	3.53	2	AKT1, PIK3CA
regulation of T cell activation (GO:0050863)	4.05	2	PIK3CA, AKT1
regulation of myelination (GO:0031641)	6.23	2	AKT1, PTEN
homeostatic process (GO:0042592)	2.61	2	PIK3CA, AKT1
glucose homeostasis (GO:0042593)	4.6	2	PIK3CA, AKT1
tricarboxylic acid cycle (GO:0006099)	6.33	2	SDHD, SDHB
positive regulation of cell death (GO:0010942)	3.32	2	AKT1, PTEN
generation of precursor metabolites and energy (GO:0006091)	4.07	2	SDHB, AKT1
angiogenesis (GO:0001525)	4.15	2	PIK3CA, PTEN
positive regulation of cell-cell adhesion (GO:0022409)	4.23	2	AKT1, PIK3CA
glycerolipid biosynthetic process (GO:0045017)	4.53	2	PTEN, PIK3CA
regulation of generation of precursor metabolites and energy (GO:0043467)	5.24	2	AKT1, PIK3CA
regulation of transcription, DNA-templated (GO:0006355)	1.56	2	AKT1, PTEN
positive regulation of protein kinase activity (GO:0045860)	3.61	2	PIK3CA, AKT1
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	2	PTEN, AKT1
carbohydrate homeostasis (GO:0033500)	4.6	2	AKT1, PIK3CA
positive regulation of apoptotic process (GO:0043065)	3.38	2	PTEN, AKT1
cellular response to organic substance (GO:0071310)	2.78	2	AKT1, PIK3CA
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	2	PTEN, AKT1
organic substance transport (GO:0071702)	2.15	2	SEC23B, AKT1
positive regulation of programmed cell death (GO:0043068)	3.38	2	PTEN, AKT1
positive regulation of cellular protein catabolic process (GO:1903364)	4.52	2	AKT1, PTEN
antigen receptor-mediated signaling pathway (GO:0050851)	4.43	2	PIK3CA, PTEN
protein phosphorylation (GO:0006468)	2.89	2	PIK3CA, AKT1
negative regulation of protein kinase activity (GO:0006469)	4.29	2	AKT1, PTEN
regulation of cellular protein catabolic process (GO:1903362)	4.23	2	PTEN, AKT1
negative regulation of phosphate metabolic process (GO:0045936)	3.45	2	PTEN, AKT1
organic substance catabolic process (GO:1901575)	2.45	2	AKT1, PTEN
reproductive process (GO:0022414)	2.55	2	PTEN, AKT1
single-organism transport (GO:0044765)	2.18	2	PIK3CA, AKT1
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	2	AKT1, PTEN
establishment of localization in cell (GO:0051649)	2.47	2	SEC23B, AKT1
catabolic process (GO:0009056)	2.38	2	PTEN, AKT1
single-organism localization (GO:1902578)	2.09	2	PIK3CA, AKT1
response to oxygen levels (GO:0070482)	4.02	2	PTEN, AKT1
locomotion (GO:0040011)	2.91	2	PTEN, PIK3CA
cellular response to oxygen-containing compound (GO:1901701)	3.22	2	PIK3CA, AKT1
regulation of cellular component movement (GO:0051270)	3.08	2	PTEN, AKT1
response to carbohydrate (GO:0009743)	4.62	2	PTEN, PIK3CA
nervous system development (GO:0007399)	3.53	2	PTEN, AKT1
regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079)	5.26	2	AKT1, PTEN
phospholipid metabolic process (GO:0006644)	3.88	2	PTEN, PIK3CA
response to glucose (GO:0009749)	4.86	2	PIK3CA, PTEN
regulation of cell cycle G1/S phase transition (GO:1902806)	4.74	2	PTEN, AKT1
regulation of multicellular organismal development (GO:2000026)	2.31	2	AKT1, PTEN
activation of immune response (GO:0002253)	3.67	2	PTEN, PIK3CA
protein transport (GO:0015031)	2.62	2	SEC23B, AKT1
regulation of proteolysis (GO:0030162)	3.2	2	PTEN, AKT1
negative regulation of protein phosphorylation (GO:0001933)	3.79	2	AKT1, PTEN

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cellular response to fibroblast growth factor stimulus (GO:0044344)	NEW	6.4	0.028	AKT1, PIK3CA, PTEN
negative regulation of fibroblast apoptotic process (GO:2000270)	NEW	7.78	0.031	AKT1, PIK3CA
regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle (GO:0031657)	-	7.53	0.036	AKT1, PTEN
myelin maintenance (GO:0043217)	-	7.24	0.041	AKT1, PTEN
protein kinase B signaling (GO:0043491)	-	6.2	0.007	AKT1, PIK3CA, PTEN
peptidyl-tyrosine modification (GO:0018212)	NEW	4.47	0.018	SEC23B, AKT1, PTEN, PIK3CA
fibroblast growth factor receptor signaling pathway (GO:0008543)	NEW	5.3	0.02	AKT1, PIK3CA, PTEN
peptidyl-tyrosine phosphorylation (GO:0018108)	NEW	4.48	0.017	SEC23B, AKT1, PTEN, PIK3CA
negative regulation of small GTPase mediated signal transduction (GO:0051058)	NEW	6.04	0.016	AKT1, PTEN, PIK3CA
response to fibroblast growth factor (GO:0071774)	NEW	6.17	0.03	AKT1, PIK3CA, PTEN
tricarboxylic acid cycle (GO:0006099)	-	6.33	0.043	SDHD, SDHB
negative regulation of cell size (GO:0045792)	-	7.53	0.005	AKT1, PTEN
epidermal growth factor receptor signaling pathway (GO:0007173)	NEW	5.72	0.032	AKT1, PIK3CA, PTEN
ERBB signaling pathway (GO:0038127)	-	5.36	0.034	AKT1, PIK3CA, PTEN
negative regulation of cytokine-mediated signaling pathway (GO:0001960)	NEW	6.07	0.011	AKT1, PTEN, PIK3CA
negative regulation of response to cytokine stimulus (GO:0060761)	NEW	5.97	0.018	AKT1, PIK3CA, PTEN
negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)	NEW	7.43	0.0	AKT1, PIK3CA, PTEN
phosphatidylinositol-mediated signaling (GO:0048015)	-	4.93	0.012	AKT1, PTEN, PIK3CA
inositol lipid-mediated signaling (GO:0048017)	-	4.91	0.012	AKT1, PTEN, PIK3CA
positive regulation of JAK-STAT cascade (GO:0046427)	NEW	5.44	0.037	AKT1, PIK3CA, PTEN

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	7	PTEN, KLLN, SEC23B, PIK3CA, SDHB, SDHD, AKT1
cell part (GO:0044464)	0.11	7	PTEN, KLLN, SEC23B, PIK3CA, SDHB, SDHD, AKT1
intracellular membrane-bounded organelle (GO:0043231)	0.6	6	PTEN, KLLN, SEC23B, SDHB, SDHD, AKT1
membrane (GO:0016020)	0.68	6	PTEN, SEC23B, PIK3CA, SDHB, SDHD, AKT1
cytoplasmic part (GO:0044444)	0.82	6	PTEN, SEC23B, PIK3CA, SDHB, SDHD, AKT1
intracellular organelle part (GO:0044446)	0.81	6	AKT1, KLLN, SEC23B, PTEN, SDHB, SDHD
intracellular organelle (GO:0043229)	0.51	6	PTEN, KLLN, SEC23B, SDHB, SDHD, AKT1
membrane-bounded organelle (GO:0043227)	0.47	6	PTEN, KLLN, SEC23B, SDHB, SDHD, AKT1
organelle (GO:0043226)	0.4	6	PTEN, KLLN, SEC23B, SDHB, SDHD, AKT1
organelle part (GO:0044422)	0.79	6	PTEN, KLLN, SEC23B, SDHB, SDHD, AKT1
protein complex (GO:0043234)	1.51	5	SDHD, SEC23B, SDHB, AKT1, PIK3CA
membrane part (GO:0044425)	0.95	5	SDHD, PTEN, SEC23B, SDHB, PIK3CA
macromolecular complex (GO:0032991)	1.35	5	SDHD, SEC23B, SDHB, AKT1, PIK3CA
membrane protein complex (GO:0098796)	2.84	4	SDHD, SEC23B, SDHB, PIK3CA
nuclear part (GO:0044428)	1.55	4	SDHB, AKT1, KLLN, PTEN
mitochondrion (GO:0005739)	2.42	4	SDHD, PTEN, SDHB, AKT1
plasma membrane (GO:0005886)	1.39	4	AKT1, SDHB, PTEN, PIK3CA
nucleoplasm (GO:0005654)	1.89	3	PTEN, SDHB, AKT1
cytosol (GO:0005829)	1.68	3	AKT1, PIK3CA, PTEN
nucleus (GO:0005634)	1.07	3	PTEN, KLLN, AKT1
catalytic complex (GO:1902494)	2.9	3	SDHD, SDHB, PIK3CA
organelle membrane (GO:0031090)	1.97	3	SDHD, SEC23B, SDHB
cytoplasm (GO:0005737)	1.01	2	AKT1, PTEN
mitochondrial membrane part (GO:0044455)	4.54	2	SDHD, SDHB
succinate dehydrogenase complex (ubiquinone) (GO:0045257)	8.42	2	SDHD, SDHB
vesicle (GO:0031982)	1.64	2	SDHB, AKT1
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	2	KLLN, AKT1
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) (GO:0005749)	8.42	2	SDHD, SDHB
organelle inner membrane (GO:0019866)	3.56	2	SDHD, SDHB
respiratory chain complex (GO:0098803)	5.47	2	SDHD, SDHB
cell projection part (GO:0044463)	2.97	2	PTEN, AKT1
fumarate reductase complex (GO:0045283)	8.42	2	SDHD, SDHB
succinate dehydrogenase complex (GO:0045281)	8.42	2	SDHD, SDHB
mitochondrial membrane (GO:0031966)	3.31	2	SDHD, SDHB
oxidoreductase complex (GO:1990204)	5.19	2	SDHD, SDHB
mitochondrial inner membrane (GO:0005743)	3.65	2	SDHD, SDHB
mitochondrial protein complex (GO:0098798)	4.78	2	SDHD, SDHB
non-membrane-bounded organelle (GO:0043228)	1.76	2	KLLN, AKT1
mitochondrial part (GO:0044429)	2.92	2	SDHD, SDHB
synapse part (GO:0044456)	3.42	2	AKT1, PTEN
cell projection (GO:0042995)	2.47	2	PIK3CA, PTEN
inner mitochondrial membrane protein complex (GO:0098800)	5.01	2	SDHD, SDHB
postsynapse (GO:0098794)	4.87	2	AKT1, PTEN

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
succinate dehydrogenase complex (ubiquinone) (GO:0045257)	-	8.42	0.0	SDHD, SDHB
catalytic complex (GO:1902494)	-	2.9	0.021	SDHD, AKT1, SDHB, PTEN, PIK3CA
oxidoreductase complex (GO:1990204)	-	5.19	0.043	SDHD, SDHB, AKT1
fumarate reductase complex (GO:0045283)	-	8.42	0.0	SDHD, SDHB
succinate dehydrogenase complex (GO:0045281)	-	8.42	0.0	SDHD, SDHB
Golgi membrane (GO:0000139)	NEW	3.28	0.005	AKT1, SDHD, SEC23B, PIK3CA, PTEN
mitochondrial membrane part (GO:0044455)	-	4.54	0.013	SDHD, SDHB, AKT1
endosome lumen (GO:0031904)	NEW	6.54	0.007	AKT1, PIK3CA
Golgi apparatus part (GO:0044431)	NEW	3.0	0.038	AKT1, SDHD, SEC23B, PIK3CA, PTEN
cytosolic part (GO:0044445)	NEW	4.34	0.032	AKT1, PIK3CA, PTEN
endomembrane system (GO:0012505)	NEW	4.84	0.003	SEC23B, PTEN, AKT1
mitochondrial respiratory chain complex II (GO:0005749)	-	8.42	0.0	SDHD, SDHB