Disease table of PARAGANGLIOMAS OMIM ID: PS168000

Gene-disease associations table

GeneAssociated with PARAGANGLIOMAS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SDHAClinVar, OMIM, HUMSAVARHGNC link5p15.335252011, 604287, PS115200, PS168000, 256000
SDHAF2ClinVar, OMIM, HUMSAVARHGNC link11q12.21PS168000
SDHBClinVar, OMIM, HUMSAVARHGNC link1p36.136171300, 604287, 606764, 606864, PS168000, PS158350
SDHCClinVar, OMIMHGNC link1q23.34604287, 606864, PS168000, 606764
SDHDClinVar, OMIM, HUMSAVARHGNC link11q23.16252011, PS168000, 606864, 114900, 171300, PS158350

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
11q2SDHD, SDHAF2
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
112SDHD, SDHAF2
12SDHB, SDHC
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SDHBYES4NRF1, NFE2L2, PLAGL1, HIF1A0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SDHASDHAF2Yes4HSPA9, OXCT1, SUCLG2, UQCRFS1
SDHASDHBYes24NDUFS8, NDUFV2, CUL1, SDHC, UQCRB, CS, UBXN10, MDH2, TIMM50, COPS5, NDUFV1, ITGA4, DLD, OTUB1, PDHA1, SUCLG1, CUL2, ACLY, SUCLA2, CAND1, ACAT1, NDUFA2, UQCRFS1, CUL3
SDHASDHCYes3NDUFS2, XRCC6, SDHB
SDHAF2SDHBNo2UQCRFS1, SDHA
SDHAF2SDHCNo1SDHA
SDHBSDHCYes2MTCH2, SDHA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SDHASDHAF2Yesbinding0
SDHASDHBYesbinding3UBC, SDHC, SDHD
SDHASDHCYesbinding3UBC, SDHD, SDHB
SDHASDHDYesbinding2SDHC, SDHB
SDHAF2SDHBNo-1SDHA
SDHAF2SDHCNo-1SDHA
SDHAF2SDHDNo-1SDHA
SDHBSDHCYesbinding3UBC, SDHD, SDHA
SDHBSDHDYesbinding2SDHC, SDHA
SDHCSDHDYesbinding3CYC1, SDHB, SDHA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SDHASDHAF2No3OXCT1, UQCRFS1, SUCLG2
SDHASDHBYes4ACAT1, TIMM50, UQCRFS1, NDUFV2
SDHAF2SDHBNo1UQCRFS1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
SDHASDHByes, complexComponents of complex composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
SDHASDHCyes, complexComponents of complex composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
SDHASDHDyes, complexComponent of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
SDHBSDHCyes, complexComponents of complex composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
SDHBSDHDyes, complexComponents of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
SDHCSDHDyes, complexComponents of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Oxidative phosphorylationhsa001905.694SDHC, SDHD, SDHB, SDHA
Metabolic pathwayshsa011002.494SDHC, SDHD, SDHB, SDHA
Carbon metabolismhsa012006.034SDHC, SDHD, SDHB, SDHA
Citrate cycle (TCA cycle)hsa000207.864SDHC, SDHD, SDHB, SDHA
Non-alcoholic fatty liver disease (NAFLD)hsa049325.514SDHC, SDHD, SDHB, SDHA
Huntington's diseasehsa050165.174SDHC, SDHD, SDHB, SDHA
Alzheimer's diseasehsa050105.344SDHC, SDHD, SDHB, SDHA
Parkinson's diseasehsa050125.594SDHC, SDHD, SDHB, SDHA

NET-GE enrichment

Term New enriched termICP valueGenes
Neurodegenerative diseasesNEW4.270.0SDHC, SDHD, SDHB, SDHA
Global and overview mapsNEW2.470.017SDHC, SDHD, SDHB, SDHA
Endocrine and metabolic diseasesNEW4.750.0SDHC, SDHD, SDHB, SDHA
Oxidative phosphorylation (hsa00190) -5.690.0SDHC, SDHD, SDHB, SDHA
Metabolic pathways (hsa01100) -2.490.016SDHC, SDHD, SDHB, SDHA
Energy metabolismNEW5.420.0SDHC, SDHD, SDHB, SDHA
Carbohydrate metabolismNEW4.360.0SDHC, SDHD, SDHB, SDHA
Citrate cycle (TCA cycle) (hsa00020) -7.860.0SDHC, SDHD, SDHB, SDHA
Carbon metabolism (hsa01200) -6.030.0SDHC, SDHD, SDHB, SDHA
Parkinson's disease (hsa05012) -5.590.0SDHC, SDHD, SDHB, SDHA
Huntington's disease (hsa05016) -5.170.0SDHC, SDHD, SDHB, SDHA
Alzheimer's disease (hsa05010) -5.340.0SDHC, SDHD, SDHB, SDHA
Non-alcoholic fatty liver disease (NAFLD) (hsa04932) -5.510.0SDHC, SDHD, SDHB, SDHA
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Respiratory electron transportR-HSA-6111056.444SDHC, SDHD, SDHB, SDHA
Pyruvate metabolism and Citric Acid (TCA) cycleR-HSA-714067.564SDHC, SDHD, SDHB, SDHA
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-1632006.124SDHC, SDHD, SDHB, SDHA
Citric acid cycle (TCA cycle)R-HSA-714038.734SDHC, SDHD, SDHB, SDHA
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.714SDHC, SDHD, SDHB, SDHA
MetabolismR-HSA-14307282.344SDHC, SDHD, SDHB, SDHA

NET-GE enrichment

Term New enriched termICP valueGenes
Respiratory electron transport (R-HSA-611105) -6.440.0SDHC, SDHD, SDHB, SDHA
Pyruvate metabolism and Citric Acid (TCA) cycle (R-HSA-71406) -7.560.0SDHC, SDHD, SDHB, SDHA
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200) -6.120.0SDHC, SDHD, SDHB, SDHA
Citric acid cycle (TCA cycle) (R-HSA-71403) -8.730.0SDHC, SDHD, SDHB, SDHA
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517) -5.710.0SDHC, SDHD, SDHB, SDHA
Metabolism (R-HSA-1430728) -2.340.011SDHC, SDHD, SDHB, SDHA
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185SDHAF2, SDHC, SDHD, SDHB, SDHA
catalytic activity (GO:0003824) 1.054SDHC, SDHD, SDHB, SDHA
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) 5.664SDHC, SDHD, SDHB, SDHA
succinate dehydrogenase activity (GO:0000104) 8.134SDHC, SDHD, SDHB, SDHA
oxidoreductase activity (GO:0016491) 3.124SDHC, SDHD, SDHB, SDHA
cation binding (GO:0043169) 1.43SDHC, SDHD, SDHB
organic cyclic compound binding (GO:0097159) 1.053SDHC, SDHD, SDHA
ion binding (GO:0043167) 1.363SDHC, SDHD, SDHB
cofactor binding (GO:0048037) 4.163SDHD, SDHB, SDHA
protein binding (GO:0005515) 0.463SDHAF2, SDHB, SDHA
metal ion binding (GO:0046872) 1.413SDHC, SDHD, SDHB
heterocyclic compound binding (GO:1901363) 1.063SDHC, SDHD, SDHA
electron carrier activity (GO:0009055) 4.973SDHC, SDHD, SDHB
heme binding (GO:0020037) 4.862SDHC, SDHD
tetrapyrrole binding (GO:0046906) 4.82SDHC, SDHD
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor (GO:0016635) 8.642SDHB, SDHA
succinate dehydrogenase (ubiquinone) activity (GO:0008177) 9.052SDHB, SDHA
ubiquinone binding (GO:0048039) 8.352SDHD, SDHB
quinone binding (GO:0048038) 6.912SDHD, SDHB

NET-GE enrichment

Term New enriched termICP valueGenes
oxidoreductase activity (GO:0016491) -3.120.005SDHC, SDHD, SDHB, SDHA
succinate dehydrogenase activity (GO:0000104) -8.130.0SDHC, SDHD, SDHB, SDHA
heme binding (GO:0020037) -4.860.021SDHC, SDHD
tetrapyrrole binding (GO:0046906) -4.80.001SDHC, SDHD, SDHA
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) -5.660.0SDHC, SDHD, SDHB, SDHA
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor (GO:0016635) -8.640.0SDHB, SDHA
cofactor binding (GO:0048037) -4.160.001SDHD, SDHB, SDHA
succinate dehydrogenase (ubiquinone) activity (GO:0008177) -9.050.0SDHB, SDHA
ubiquinone binding (GO:0048039) -8.350.0SDHD, SDHB
quinone binding (GO:0048038) -6.910.001SDHD, SDHB
electron carrier activity (GO:0009055) -4.970.0SDHC, SDHD, SDHB
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
primary metabolic process (GO:0044238) 0.695SDHAF2, SDHC, SDHD, SDHB, SDHA
single-organism metabolic process (GO:0044710) 1.635SDHAF2, SDHC, SDHD, SDHB, SDHA
cellular process (GO:0009987) 0.265SDHB, SDHC, SDHD, SDHAF2, SDHA
cellular metabolic process (GO:0044237) 0.695SDHAF2, SDHC, SDHD, SDHB, SDHA
organic substance metabolic process (GO:0071704) 0.635SDHAF2, SDHC, SDHD, SDHB, SDHA
single-organism cellular process (GO:0044763) 0.655SDHAF2, SDHD, SDHB, SDHA, SDHC
single-organism process (GO:0044699) 0.485SDHAF2, SDHD, SDHB, SDHA, SDHC
metabolic process (GO:0008152) 0.585SDHAF2, SDHD, SDHB, SDHA, SDHC
oxidation-reduction process (GO:0055114) 2.915SDHB, SDHC, SDHD, SDHAF2, SDHA
organic acid metabolic process (GO:0006082) 3.014SDHC, SDHD, SDHB, SDHA
tricarboxylic acid cycle (GO:0006099) 6.334SDHC, SDHD, SDHB, SDHA
electron transport chain (GO:0022900) 5.094SDHAF2, SDHC, SDHB, SDHA
small molecule metabolic process (GO:0044281) 2.384SDHC, SDHD, SDHB, SDHA
respiratory electron transport chain (GO:0022904) 5.114SDHAF2, SDHB, SDHA, SDHC
generation of precursor metabolites and energy (GO:0006091) 4.074SDHAF2, SDHC, SDHB, SDHA
dicarboxylic acid metabolic process (GO:0043648) 5.32SDHB, SDHA
energy derivation by oxidation of organic compounds (GO:0015980) 4.932SDHC, SDHB
mitochondrial electron transport, succinate to ubiquinone (GO:0006121) 9.042SDHAF2, SDHC
succinate metabolic process (GO:0006105) 7.432SDHB, SDHA
aerobic respiration (GO:0009060) 6.42SDHC, SDHB
cellular respiration (GO:0045333) 5.92SDHC, SDHB
carboxylic acid metabolic process (GO:0019752) 3.122SDHB, SDHA
oxoacid metabolic process (GO:0043436) 3.122SDHB, SDHA

NET-GE enrichment

Term New enriched termICP valueGenes
dicarboxylic acid metabolic process (GO:0043648) -5.30.016SDHB, SDHA
electron transport chain (GO:0022900) -5.090.0SDHAF2, SDHC, SDHD, SDHB, SDHA
succinate metabolic process (GO:0006105) -7.430.0SDHB, SDHA
tricarboxylic acid cycle (GO:0006099) -6.330.0SDHC, SDHD, SDHB, SDHA
aerobic respiration (GO:0009060) -6.40.001SDHC, SDHB
cellular respiration (GO:0045333) -5.90.003SDHC, SDHB
respiratory electron transport chain (GO:0022904) -5.110.0SDHB, SDHC, SDHD, SDHAF2, SDHA
generation of precursor metabolites and energy (GO:0006091) -4.070.0SDHAF2, SDHC, SDHD, SDHB, SDHA
oxidation-reduction process (GO:0055114) -2.910.0SDHB, SDHC, SDHD, SDHAF2, SDHA
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.65SDHAF2, SDHC, SDHD, SDHB, SDHA
cell part (GO:0044464) 0.115SDHAF2, SDHD, SDHB, SDHA, SDHC
cytoplasmic part (GO:0044444) 0.825SDHAF2, SDHC, SDHD, SDHB, SDHA
mitochondrion (GO:0005739) 2.425SDHAF2, SDHD, SDHB, SDHA, SDHC
intracellular organelle part (GO:0044446) 0.815SDHAF2, SDHD, SDHB, SDHA, SDHC
intracellular organelle (GO:0043229) 0.515SDHB, SDHC, SDHD, SDHAF2, SDHA
mitochondrial part (GO:0044429) 2.925SDHAF2, SDHC, SDHD, SDHB, SDHA
intracellular part (GO:0044424) 0.285SDHAF2, SDHD, SDHB, SDHA, SDHC
membrane-bounded organelle (GO:0043227) 0.475SDHAF2, SDHC, SDHD, SDHB, SDHA
organelle (GO:0043226) 0.45SDHAF2, SDHC, SDHD, SDHB, SDHA
organelle part (GO:0044422) 0.795SDHB, SDHC, SDHD, SDHAF2, SDHA
protein complex (GO:0043234) 1.514SDHC, SDHD, SDHB, SDHA
succinate dehydrogenase complex (ubiquinone) (GO:0045257) 8.424SDHC, SDHD, SDHB, SDHA
macromolecular complex (GO:0032991) 1.354SDHC, SDHD, SDHB, SDHA
catalytic complex (GO:1902494) 2.94SDHC, SDHD, SDHB, SDHA
membrane protein complex (GO:0098796) 2.844SDHC, SDHD, SDHB, SDHA
organelle inner membrane (GO:0019866) 3.564SDHC, SDHD, SDHB, SDHA
membrane (GO:0016020) 0.684SDHC, SDHD, SDHB, SDHA
fumarate reductase complex (GO:0045283) 8.424SDHC, SDHD, SDHB, SDHA
succinate dehydrogenase complex (GO:0045281) 8.424SDHC, SDHD, SDHB, SDHA
inner mitochondrial membrane protein complex (GO:0098800) 5.014SDHC, SDHD, SDHB, SDHA
mitochondrial membrane part (GO:0044455) 4.544SDHC, SDHD, SDHB, SDHA
mitochondrial inner membrane (GO:0005743) 3.654SDHC, SDHD, SDHB, SDHA
mitochondrial protein complex (GO:0098798) 4.784SDHC, SDHD, SDHB, SDHA
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) (GO:0005749) 8.424SDHC, SDHD, SDHB, SDHA
membrane part (GO:0044425) 0.954SDHC, SDHD, SDHB, SDHA
respiratory chain complex (GO:0098803) 5.474SDHC, SDHD, SDHB, SDHA
mitochondrial membrane (GO:0031966) 3.314SDHC, SDHD, SDHB, SDHA
oxidoreductase complex (GO:1990204) 5.194SDHC, SDHD, SDHB, SDHA
organelle membrane (GO:0031090) 1.974SDHC, SDHD, SDHB, SDHA
respiratory chain complex II (GO:0045273) 9.112SDHC, SDHB
integral component of membrane (GO:0016021) 1.142SDHC, SDHD
intrinsic component of membrane (GO:0031224) 1.132SDHC, SDHD

NET-GE enrichment

Term New enriched termICP valueGenes
succinate dehydrogenase complex (ubiquinone) (GO:0045257) -8.420.0SDHC, SDHD, SDHB, SDHA
catalytic complex (GO:1902494) -2.90.001SDHC, SDHD, SDHB, SDHA
mitochondrial respiratory chain complex II (GO:0005749) -8.420.0SDHC, SDHD, SDHB, SDHA
fumarate reductase complex (GO:0045283) -8.420.0SDHC, SDHD, SDHB, SDHA
organelle inner membrane (GO:0019866) -3.560.0SDHC, SDHD, SDHB, SDHA
mitochondrion (GO:0005739) -2.420.005SDHB, SDHC, SDHD, SDHAF2, SDHA
mitochondrial membrane (GO:0031966) -3.310.0SDHC, SDHD, SDHB, SDHA
mitochondrial membrane part (GO:0044455) -4.540.0SDHC, SDHD, SDHB, SDHA
mitochondrial inner membrane (GO:0005743) -3.650.0SDHC, SDHD, SDHB, SDHA
mitochondrial envelope (GO:0005740) NEW6.910.0SDHD, SDHA
mitochondrial part (GO:0044429) -2.920.015SDHC, SDHD, SDHB, SDHA
succinate dehydrogenase complex (GO:0045281) -8.420.0SDHC, SDHD, SDHB, SDHA
oxidoreductase complex (GO:1990204) -5.190.0SDHC, SDHD, SDHB, SDHA