Disease table of CARNEY TRIAD OMIM ID: 604287

Gene-disease associations table

GeneAssociated with CARNEY TRIAD inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SDHAClinVarHGNC link5p15.335252011, 604287, PS115200, PS168000, 256000
SDHCClinVarHGNC link1q23.34604287, 606864, PS168000, 606764
SDHBClinVarHGNC link1p36.136171300, 604287, 606764, 606864, PS168000, PS158350

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
12SDHB, SDHC
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SDHBYES4NRF1, NFE2L2, PLAGL1, HIF1A0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SDHASDHCYes3NDUFS2, XRCC6, SDHB
SDHASDHBYes24NDUFS8, NDUFV2, CUL1, SDHC, UQCRB, CS, UBXN10, MDH2, TIMM50, COPS5, NDUFV1, ITGA4, DLD, OTUB1, PDHA1, SUCLG1, CUL2, ACLY, SUCLA2, CAND1, ACAT1, NDUFA2, UQCRFS1, CUL3
SDHCSDHBYes2MTCH2, SDHA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SDHASDHCYesbinding3UBC, SDHD, SDHB
SDHASDHBYesbinding3UBC, SDHC, SDHD
SDHCSDHBYesbinding3UBC, SDHD, SDHA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SDHASDHBYes4ACAT1, TIMM50, UQCRFS1, NDUFV2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
SDHASDHByes, complexComponents of complex composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
SDHASDHCyes, complexComponents of complex composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
SDHBSDHCyes, complexComponents of complex composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Oxidative phosphorylationhsa001905.693SDHC, SDHB, SDHA
Metabolic pathwayshsa011002.493SDHC, SDHB, SDHA
Carbon metabolismhsa012006.033SDHC, SDHB, SDHA
Citrate cycle (TCA cycle)hsa000207.863SDHC, SDHB, SDHA
Non-alcoholic fatty liver disease (NAFLD)hsa049325.513SDHC, SDHB, SDHA
Huntington's diseasehsa050165.173SDHC, SDHB, SDHA
Alzheimer's diseasehsa050105.343SDHC, SDHB, SDHA
Parkinson's diseasehsa050125.593SDHC, SDHB, SDHA

NET-GE enrichment

Term New enriched termICP valueGenes
Neurodegenerative diseasesNEW4.270.002SDHC, SDHB, SDHA
Endocrine and metabolic diseasesNEW4.750.005SDHC, SDHB, SDHA
Oxidative phosphorylation (hsa00190) -5.690.0SDHC, SDHB, SDHA
Parkinson's disease (hsa05012) -5.590.0SDHC, SDHB, SDHA
Energy metabolismNEW5.420.0SDHC, SDHB, SDHA
Carbohydrate metabolismNEW4.360.002SDHC, SDHB, SDHA
Carbon metabolism (hsa01200) -6.030.0SDHC, SDHB, SDHA
Non-alcoholic fatty liver disease (NAFLD) (hsa04932) -5.510.0SDHC, SDHB, SDHA
Huntington's disease (hsa05016) -5.170.001SDHC, SDHB, SDHA
Alzheimer's disease (hsa05010) -5.340.0SDHC, SDHB, SDHA
Citrate cycle (TCA cycle) (hsa00020) -7.860.0SDHC, SDHB, SDHA
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Respiratory electron transportR-HSA-6111056.443SDHC, SDHB, SDHA
Pyruvate metabolism and Citric Acid (TCA) cycleR-HSA-714067.563SDHC, SDHB, SDHA
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-1632006.123SDHC, SDHB, SDHA
Citric acid cycle (TCA cycle)R-HSA-714038.733SDHC, SDHB, SDHA
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.713SDHC, SDHB, SDHA
MetabolismR-HSA-14307282.343SDHC, SDHB, SDHA

NET-GE enrichment

Term New enriched termICP valueGenes
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517) -5.710.0SDHC, SDHB, SDHA
Respiratory electron transport (R-HSA-611105) -6.440.0SDHC, SDHB, SDHA
Pyruvate metabolism and Citric Acid (TCA) cycle (R-HSA-71406) -7.560.0SDHC, SDHB, SDHA
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200) -6.120.0SDHC, SDHB, SDHA
Citric acid cycle (TCA cycle) (R-HSA-71403) -8.730.0SDHC, SDHB, SDHA
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.053SDHC, SDHB, SDHA
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) 5.663SDHC, SDHB, SDHA
succinate dehydrogenase activity (GO:0000104) 8.133SDHC, SDHB, SDHA
binding (GO:0005488) 0.183SDHC, SDHB, SDHA
oxidoreductase activity (GO:0016491) 3.123SDHC, SDHB, SDHA
cation binding (GO:0043169) 1.42SDHC, SDHB
organic cyclic compound binding (GO:0097159) 1.052SDHC, SDHA
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor (GO:0016635) 8.642SDHB, SDHA
ion binding (GO:0043167) 1.362SDHC, SDHB
cofactor binding (GO:0048037) 4.162SDHB, SDHA
succinate dehydrogenase (ubiquinone) activity (GO:0008177) 9.052SDHB, SDHA
protein binding (GO:0005515) 0.462SDHB, SDHA
metal ion binding (GO:0046872) 1.412SDHC, SDHB
heterocyclic compound binding (GO:1901363) 1.062SDHC, SDHA
electron carrier activity (GO:0009055) 4.972SDHC, SDHB

NET-GE enrichment

Term New enriched termICP valueGenes
succinate dehydrogenase activity (GO:0000104) -8.130.0SDHC, SDHB, SDHA
tetrapyrrole binding (GO:0046906) NEW4.80.024SDHC, SDHA
oxidoreductase activity, acting on the CH-CH group of donors (GO:0016627) -5.660.0SDHC, SDHB, SDHA
oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor (GO:0016635) -8.640.0SDHB, SDHA
cofactor binding (GO:0048037) -4.160.025SDHB, SDHA
succinate dehydrogenase (ubiquinone) activity (GO:0008177) -9.050.0SDHB, SDHA
oxidoreductase activity (GO:0016491) -3.120.029SDHC, SDHB, SDHA
electron carrier activity (GO:0009055) -4.970.003SDHC, SDHB
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
primary metabolic process (GO:0044238) 0.693SDHC, SDHB, SDHA
single-organism metabolic process (GO:0044710) 1.633SDHC, SDHB, SDHA
organic acid metabolic process (GO:0006082) 3.013SDHC, SDHB, SDHA
cellular process (GO:0009987) 0.263SDHC, SDHB, SDHA
oxidation-reduction process (GO:0055114) 2.913SDHC, SDHB, SDHA
cellular metabolic process (GO:0044237) 0.693SDHC, SDHB, SDHA
organic substance metabolic process (GO:0071704) 0.633SDHC, SDHB, SDHA
tricarboxylic acid cycle (GO:0006099) 6.333SDHC, SDHB, SDHA
electron transport chain (GO:0022900) 5.093SDHC, SDHB, SDHA
single-organism cellular process (GO:0044763) 0.653SDHC, SDHB, SDHA
small molecule metabolic process (GO:0044281) 2.383SDHC, SDHB, SDHA
metabolic process (GO:0008152) 0.583SDHC, SDHB, SDHA
respiratory electron transport chain (GO:0022904) 5.113SDHC, SDHB, SDHA
generation of precursor metabolites and energy (GO:0006091) 4.073SDHC, SDHB, SDHA
single-organism process (GO:0044699) 0.483SDHC, SDHB, SDHA
dicarboxylic acid metabolic process (GO:0043648) 5.32SDHB, SDHA
energy derivation by oxidation of organic compounds (GO:0015980) 4.932SDHC, SDHB
carboxylic acid metabolic process (GO:0019752) 3.122SDHB, SDHA
succinate metabolic process (GO:0006105) 7.432SDHB, SDHA
aerobic respiration (GO:0009060) 6.42SDHC, SDHB
cellular respiration (GO:0045333) 5.92SDHC, SDHB
oxoacid metabolic process (GO:0043436) 3.122SDHB, SDHA

NET-GE enrichment

Term New enriched termICP valueGenes
dicarboxylic acid metabolic process (GO:0043648) -5.30.005SDHB, SDHA
aerobic respiration (GO:0009060) -6.40.0SDHC, SDHB
energy derivation by oxidation of organic compounds (GO:0015980) -4.930.043SDHC, SDHB
succinate metabolic process (GO:0006105) -7.430.0SDHB, SDHA
tricarboxylic acid cycle (GO:0006099) -6.330.0SDHC, SDHB, SDHA
electron transport chain (GO:0022900) -5.090.0SDHC, SDHB, SDHA
cellular respiration (GO:0045333) -5.90.001SDHC, SDHB
respiratory electron transport chain (GO:0022904) -5.110.0SDHC, SDHB, SDHA
generation of precursor metabolites and energy (GO:0006091) -4.070.0SDHC, SDHB, SDHA
oxidation-reduction process (GO:0055114) -2.910.005SDHC, SDHB, SDHA
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
respiratory chain complex (GO:0098803) 5.473SDHC, SDHB, SDHA
oxidoreductase complex (GO:1990204) 5.193SDHC, SDHB, SDHA
intracellular organelle (GO:0043229) 0.513SDHC, SDHB, SDHA
succinate dehydrogenase complex (GO:0045281) 8.423SDHC, SDHB, SDHA
membrane-bounded organelle (GO:0043227) 0.473SDHC, SDHB, SDHA
organelle (GO:0043226) 0.43SDHC, SDHB, SDHA
organelle membrane (GO:0031090) 1.973SDHC, SDHB, SDHA
membrane protein complex (GO:0098796) 2.843SDHC, SDHB, SDHA
membrane (GO:0016020) 0.683SDHC, SDHB, SDHA
fumarate reductase complex (GO:0045283) 8.423SDHC, SDHB, SDHA
mitochondrion (GO:0005739) 2.423SDHC, SDHB, SDHA
inner mitochondrial membrane protein complex (GO:0098800) 5.013SDHC, SDHB, SDHA
mitochondrial membrane part (GO:0044455) 4.543SDHC, SDHB, SDHA
catalytic complex (GO:1902494) 2.93SDHC, SDHB, SDHA
mitochondrial membrane (GO:0031966) 3.313SDHC, SDHB, SDHA
membrane part (GO:0044425) 0.953SDHC, SDHB, SDHA
protein complex (GO:0043234) 1.513SDHC, SDHB, SDHA
succinate dehydrogenase complex (ubiquinone) (GO:0045257) 8.423SDHC, SDHB, SDHA
macromolecular complex (GO:0032991) 1.353SDHC, SDHB, SDHA
intracellular membrane-bounded organelle (GO:0043231) 0.63SDHC, SDHB, SDHA
cell part (GO:0044464) 0.113SDHC, SDHB, SDHA
intracellular organelle part (GO:0044446) 0.813SDHC, SDHB, SDHA
mitochondrial inner membrane (GO:0005743) 3.653SDHC, SDHB, SDHA
cytoplasmic part (GO:0044444) 0.823SDHC, SDHB, SDHA
mitochondrial part (GO:0044429) 2.923SDHC, SDHB, SDHA
intracellular part (GO:0044424) 0.283SDHC, SDHB, SDHA
organelle inner membrane (GO:0019866) 3.563SDHC, SDHB, SDHA
mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) (GO:0005749) 8.423SDHC, SDHB, SDHA
organelle part (GO:0044422) 0.793SDHC, SDHB, SDHA
mitochondrial protein complex (GO:0098798) 4.783SDHC, SDHB, SDHA
respiratory chain complex II (GO:0045273) 9.112SDHC, SDHB

NET-GE enrichment

Term New enriched termICP valueGenes
succinate dehydrogenase complex (ubiquinone) (GO:0045257) -8.420.0SDHC, SDHB, SDHA
catalytic complex (GO:1902494) -2.90.028SDHC, SDHB, SDHA
fumarate reductase complex (GO:0045283) -8.420.0SDHC, SDHB, SDHA
organelle inner membrane (GO:0019866) -3.560.002SDHC, SDHB, SDHA
succinate dehydrogenase complex (GO:0045281) -8.420.0SDHC, SDHB, SDHA
oxidoreductase complex (GO:1990204) -5.190.0SDHC, SDHB, SDHA
mitochondrial membrane part (GO:0044455) -4.540.0SDHC, SDHB, SDHA
mitochondrial inner membrane (GO:0005743) -3.650.001SDHC, SDHB, SDHA
mitochondrion (GO:0005739) -2.420.01SDHC, SDHB, SDHA
mitochondrial respiratory chain complex II (GO:0005749) -8.420.0SDHC, SDHB, SDHA
mitochondrial membrane (GO:0031966) -3.310.001SDHC, SDHB, SDHA
mitochondrial part (GO:0044429) -2.920.025SDHC, SDHB, SDHA