biological regulation (GO:0065007) | 0.39 | 17 | CFI, CX3CR1, RAX2, APOE, C2, HTRA1, ABCA4, CFHR1, C3, FBLN5, CFH, ERCC6, TLR4, CFB, CST3, C9, ARMS2 |
regulation of biological process (GO:0050789) | 0.45 | 16 | CFI, CX3CR1, ERCC6, RAX2, C2, HTRA1, C9, CFHR1, C3, FBLN5, CFH, CFB, CST3, APOE, ABCA4, TLR4 |
response to stimulus (GO:0050896) | 1.22 | 15 | CFI, CX3CR1, ERCC6, RAX2, C2, C9, CFHR1, HMCN1, C3, CFH, CFB, CST3, APOE, ABCA4, TLR4 |
primary metabolic process (GO:0044238) | 0.69 | 14 | CFI, ERCC6, RAX2, APOE, C2, HTRA1, ABCA4, CFHR1, C3, CFH, CFB, CST3, C9, TLR4 |
metabolic process (GO:0008152) | 0.58 | 14 | CFI, ERCC6, RAX2, APOE, C2, HTRA1, ABCA4, CFHR1, C3, CFH, CFB, CST3, C9, TLR4 |
organic substance metabolic process (GO:0071704) | 0.63 | 14 | CFI, ERCC6, RAX2, APOE, C2, HTRA1, ABCA4, CFHR1, C3, CFH, CFB, CST3, C9, TLR4 |
regulation of response to stimulus (GO:0048583) | 1.54 | 13 | CFI, CX3CR1, CFB, APOE, HTRA1, C9, CFHR1, C3, FBLN5, CFH, ERCC6, C2, TLR4 |
regulation of metabolic process (GO:0019222) | 1.02 | 13 | CFI, ERCC6, APOE, HTRA1, RAX2, C2, C3, FBLN5, CFH, CFB, CST3, C9, TLR4 |
macromolecule metabolic process (GO:0043170) | 0.83 | 13 | CFI, CFB, RAX2, HTRA1, C9, CFHR1, C3, CFH, ERCC6, CST3, APOE, C2, TLR4 |
positive regulation of biological process (GO:0048518) | 1.2 | 12 | CFI, CX3CR1, CFB, APOE, HTRA1, C9, CFHR1, C3, CFH, ERCC6, C2, TLR4 |
regulation of macromolecule metabolic process (GO:0060255) | 1.08 | 12 | CFI, ERCC6, APOE, HTRA1, RAX2, C2, C3, CFH, CFB, CST3, C9, TLR4 |
regulation of response to stress (GO:0080134) | 2.53 | 12 | CFI, CX3CR1, ERCC6, APOE, HTRA1, C9, C3, FBLN5, CFH, CFB, C2, TLR4 |
regulation of primary metabolic process (GO:0080090) | 1.08 | 12 | CFI, ERCC6, APOE, HTRA1, RAX2, C2, C3, CFH, CFB, CST3, C9, TLR4 |
response to stress (GO:0006950) | 1.8 | 11 | CFI, CX3CR1, ERCC6, APOE, C9, C3, CFH, CFB, CST3, C2, TLR4 |
cellular process (GO:0009987) | 0.26 | 11 | CX3CR1, RAX2, APOE, HTRA1, ABCA4, C3, FBLN5, ERCC6, CST3, C9, TLR4 |
regulation of gene expression (GO:0010468) | 1.37 | 11 | CFI, ERCC6, APOE, HTRA1, RAX2, C2, C3, CFH, CFB, C9, TLR4 |
regulation of cellular process (GO:0050794) | 0.5 | 11 | CX3CR1, RAX2, APOE, HTRA1, ABCA4, C2, C3, FBLN5, ERCC6, CST3, TLR4 |
protein metabolic process (GO:0019538) | 1.45 | 10 | CFI, HTRA1, C9, CFHR1, C3, CFH, CFB, CST3, C2, TLR4 |
regulation of protein metabolic process (GO:0051246) | 1.93 | 10 | CFI, CFB, APOE, C9, C2, C3, CFH, ERCC6, CST3, TLR4 |
regulation of defense response (GO:0031347) | 3.11 | 10 | CFI, CX3CR1, APOE, HTRA1, C9, C3, CFH, CFB, C2, TLR4 |
regulation of response to external stimulus (GO:0032101) | 3.06 | 10 | CFI, CX3CR1, APOE, HTRA1, C9, C3, CFH, CFB, C2, TLR4 |
defense response (GO:0006952) | 2.78 | 9 | CFI, CX3CR1, C9, C3, CFH, CFB, CST3, C2, TLR4 |
positive regulation of response to stimulus (GO:0048584) | 2.18 | 9 | CFI, CFB, C9, CFHR1, C3, CFH, ERCC6, C2, TLR4 |
regulation of inflammatory response (GO:0050727) | 4.03 | 9 | CFI, CX3CR1, APOE, C9, C3, CFH, CFB, C2, TLR4 |
immune system process (GO:0002376) | 2.29 | 9 | CFI, CX3CR1, C9, CFHR1, C3, CFH, CFB, C2, TLR4 |
regulation of immune system process (GO:0002682) | 2.5 | 9 | CFI, HTRA1, C9, CFHR1, C3, CFH, CFB, C2, TLR4 |
immune effector process (GO:0002252) | 3.58 | 9 | CFI, CX3CR1, C9, CFHR1, C3, CFH, CFB, C2, TLR4 |
single-organism process (GO:0044699) | 0.48 | 9 | CX3CR1, FBLN5, APOE, HTRA1, ABCA4, C3, ERCC6, CST3, TLR4 |
regulation of immune response (GO:0050776) | 2.98 | 8 | CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4 |
regulation of cellular metabolic process (GO:0031323) | 1.07 | 8 | RAX2, APOE, HTRA1, CST3, C3, FBLN5, ERCC6, TLR4 |
regulation of immune effector process (GO:0002697) | 3.71 | 8 | CFI, HTRA1, C9, C3, CFH, CFB, C2, TLR4 |
positive regulation of immune response (GO:0050778) | 3.4 | 8 | CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4 |
positive regulation of immune system process (GO:0002684) | 2.96 | 8 | CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4 |
multicellular organismal process (GO:0032501) | 1.45 | 8 | CX3CR1, RAX2, APOE, ABCA4, C3, HMCN1, ERCC6, TLR4 |
single-organism cellular process (GO:0044763) | 0.65 | 8 | CX3CR1, APOE, HTRA1, CST3, C3, FBLN5, ABCA4, TLR4 |
activation of immune response (GO:0002253) | 3.67 | 8 | CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4 |
immune response (GO:0006955) | 2.86 | 8 | CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4 |
regulation of proteolysis (GO:0030162) | 3.2 | 8 | CFI, APOE, C2, C3, CFH, CFB, CST3, C9 |
regulation of biological quality (GO:0065008) | 1.68 | 7 | CX3CR1, APOE, ABCA4, C3, ARMS2, C9, TLR4 |
protein activation cascade (GO:0072376) | 5.21 | 7 | CFI, C9, CFHR1, C3, CFH, CFB, C2 |
innate immune response (GO:0045087) | 3.55 | 7 | CFI, C9, C3, CFH, CFB, C2, TLR4 |
cellular metabolic process (GO:0044237) | 0.69 | 7 | RAX2, APOE, ABCA4, C3, ERCC6, CST3, TLR4 |
regulation of cellular component organization (GO:0051128) | 2.01 | 7 | APOE, HTRA1, CST3, C3, FBLN5, C2, TLR4 |
complement activation (GO:0006956) | 5.49 | 7 | CFI, C9, CFHR1, C3, CFH, CFB, C2 |
humoral immune response (GO:0006959) | 4.59 | 7 | CFI, C9, CFHR1, C3, CFH, CFB, C2 |
positive regulation of cellular process (GO:0048522) | 1.3 | 7 | CX3CR1, APOE, HTRA1, C2, C3, ERCC6, TLR4 |
regulation of protein processing (GO:0070613) | 5.35 | 6 | CFI, C2, C3, CFH, CFB, C9 |
regulation of complement activation (GO:0030449) | 6.23 | 6 | CFI, C2, C3, CFH, CFB, C9 |
single-multicellular organism process (GO:0044707) | 1.78 | 6 | CX3CR1, APOE, ABCA4, C3, ERCC6, TLR4 |
regulation of signal transduction (GO:0009966) | 1.84 | 6 | CX3CR1, APOE, HTRA1, C3, ERCC6, TLR4 |
regulation of cellular biosynthetic process (GO:0031326) | 1.38 | 6 | RAX2, APOE, HTRA1, C3, ERCC6, TLR4 |
regulation of signaling (GO:0023051) | 1.72 | 6 | CX3CR1, APOE, HTRA1, C3, ERCC6, TLR4 |
regulation of biosynthetic process (GO:0009889) | 1.37 | 6 | RAX2, APOE, HTRA1, C3, ERCC6, TLR4 |
regulation of protein activation cascade (GO:2000257) | 6.17 | 6 | CFI, C2, C3, CFH, CFB, C9 |
regulation of humoral immune response (GO:0002920) | 5.82 | 6 | CFI, C2, C3, CFH, CFB, C9 |
signal transduction (GO:0007165) | 1.28 | 6 | CX3CR1, APOE, ABCA4, C3, ERCC6, TLR4 |
negative regulation of biological process (GO:0048519) | 1.33 | 6 | CX3CR1, APOE, HTRA1, CST3, C3, TLR4 |
regulation of acute inflammatory response (GO:0002673) | 5.41 | 6 | CFI, C2, C3, CFH, CFB, C9 |
response to chemical (GO:0042221) | 1.98 | 6 | CX3CR1, APOE, C2, C3, ERCC6, TLR4 |
regulation of protein maturation (GO:1903317) | 5.33 | 6 | CFI, C2, C3, CFH, CFB, C9 |
regulation of cell communication (GO:0010646) | 1.73 | 6 | CX3CR1, APOE, HTRA1, C3, ERCC6, TLR4 |
negative regulation of cellular process (GO:0048523) | 1.41 | 6 | CX3CR1, APOE, HTRA1, CST3, C3, TLR4 |
system process (GO:0003008) | 2.3 | 6 | CX3CR1, RAX2, APOE, ABCA4, HMCN1, TLR4 |
response to oxygen-containing compound (GO:1901700) | 2.57 | 5 | CX3CR1, ERCC6, APOE, C3, TLR4 |
transport (GO:0006810) | 1.51 | 5 | FBLN5, CFI, ABCA4, TLR4, APOE |
cellular macromolecule metabolic process (GO:0044260) | 0.93 | 5 | ERCC6, CST3, APOE, RAX2, TLR4 |
response to external stimulus (GO:0009605) | 2.55 | 5 | CX3CR1, C2, ABCA4, APOE, TLR4 |
regulation of molecular function (GO:0065009) | 1.78 | 5 | CST3, ERCC6, APOE, C3, TLR4 |
regulation of nucleobase-containing compound metabolic process (GO:0019219) | 1.43 | 5 | APOE, HTRA1, ERCC6, RAX2, TLR4 |
regulation of catalytic activity (GO:0050790) | 1.97 | 5 | CST3, ERCC6, APOE, C3, TLR4 |
cellular component organization (GO:0016043) | 1.24 | 5 | HTRA1, CST3, ABCA4, APOE, FBLN5 |
regulation of developmental process (GO:0050793) | 2.1 | 5 | CX3CR1, CST3, APOE, C3, TLR4 |
regulation of cellular protein metabolic process (GO:0032268) | 1.99 | 5 | CST3, ERCC6, APOE, C3, TLR4 |
regulation of nitrogen compound metabolic process (GO:0051171) | 1.36 | 5 | APOE, HTRA1, ERCC6, RAX2, TLR4 |
regulation of multicellular organismal process (GO:0051239) | 1.87 | 5 | CX3CR1, CST3, APOE, C3, TLR4 |
proteolysis (GO:0006508) | 2.73 | 5 | HTRA1, CFI, C2, CFB, C3 |
regulation of localization (GO:0032879) | 1.94 | 5 | CX3CR1, C2, APOE, C3, TLR4 |
establishment of localization (GO:0051234) | 1.48 | 5 | FBLN5, CFI, ABCA4, TLR4, APOE |
localization (GO:0051179) | 1.4 | 5 | FBLN5, CFI, ABCA4, TLR4, APOE |
cellular component organization or biogenesis (GO:0071840) | 1.22 | 5 | HTRA1, CST3, ABCA4, APOE, FBLN5 |
developmental process (GO:0032502) | 1.36 | 4 | HTRA1, APOE, ERCC6, TLR4 |
negative regulation of metabolic process (GO:0009892) | 1.93 | 4 | CST3, APOE, C3, TLR4 |
positive regulation of metabolic process (GO:0009893) | 1.74 | 4 | ERCC6, APOE, C3, TLR4 |
regulation of anatomical structure morphogenesis (GO:0022603) | 2.79 | 4 | CX3CR1, CST3, APOE, C3 |
regulation of transport (GO:0051049) | 2.24 | 4 | C2, APOE, C3, TLR4 |
negative regulation of response to stimulus (GO:0048585) | 2.52 | 4 | HTRA1, CX3CR1, TLR4, APOE |
negative regulation of cellular metabolic process (GO:0031324) | 2.01 | 4 | CST3, APOE, C3, TLR4 |
negative regulation of signaling (GO:0023057) | 2.65 | 4 | HTRA1, CX3CR1, TLR4, APOE |
negative regulation of cell communication (GO:0010648) | 2.66 | 4 | HTRA1, CX3CR1, APOE, TLR4 |
regulation of phosphate metabolic process (GO:0019220) | 2.35 | 4 | ERCC6, APOE, C3, TLR4 |
regulation of MAPK cascade (GO:0043408) | 3.22 | 4 | ERCC6, APOE, C3, TLR4 |
cellular response to stimulus (GO:0051716) | 1.97 | 4 | CX3CR1, ERCC6, APOE, TLR4 |
negative regulation of macromolecule metabolic process (GO:0010605) | 2.01 | 4 | CST3, APOE, C3, TLR4 |
positive regulation of macromolecule metabolic process (GO:0010604) | 1.81 | 4 | ERCC6, APOE, C3, TLR4 |
negative regulation of signal transduction (GO:0009968) | 2.75 | 4 | HTRA1, CX3CR1, TLR4, APOE |
positive regulation of phosphorus metabolic process (GO:0010562) | 2.78 | 4 | ERCC6, APOE, C3, TLR4 |
negative regulation of multicellular organismal process (GO:0051241) | 2.84 | 4 | CST3, CX3CR1, APOE, TLR4 |
regulation of cellular macromolecule biosynthetic process (GO:2000112) | 1.46 | 4 | HTRA1, ERCC6, RAX2, TLR4 |
positive regulation of protein metabolic process (GO:0051247) | 2.43 | 4 | ERCC6, APOE, C3, TLR4 |
positive regulation of cellular protein metabolic process (GO:0032270) | 2.49 | 4 | ERCC6, APOE, C3, TLR4 |
regulation of protein modification process (GO:0031399) | 2.32 | 4 | ERCC6, APOE, C3, TLR4 |
positive regulation of cellular metabolic process (GO:0031325) | 1.81 | 4 | ERCC6, APOE, C3, TLR4 |
regulation of cell proliferation (GO:0042127) | 2.41 | 4 | HTRA1, CX3CR1, TLR4, APOE |
negative regulation of developmental process (GO:0051093) | 3.17 | 4 | CST3, CX3CR1, APOE, TLR4 |
positive regulation of phosphate metabolic process (GO:0045937) | 2.78 | 4 | ERCC6, APOE, C3, TLR4 |
positive regulation of transport (GO:0051050) | 2.9 | 4 | C2, APOE, C3, TLR4 |
neurological system process (GO:0050877) | 2.64 | 4 | CX3CR1, HMCN1, ABCA4, RAX2 |
negative regulation of protein metabolic process (GO:0051248) | 2.82 | 4 | CST3, APOE, C3, TLR4 |
regulation of nucleic acid-templated transcription (GO:1903506) | 1.55 | 4 | HTRA1, ERCC6, RAX2, TLR4 |
single-organism developmental process (GO:0044767) | 1.49 | 4 | HTRA1, ERCC6, APOE, TLR4 |
single-organism transport (GO:0044765) | 2.18 | 4 | ABCA4, FBLN5, APOE, TLR4 |
complement activation, alternative pathway (GO:0006957) | 7.16 | 4 | C9, CFB, C3, CFH |
regulation of RNA biosynthetic process (GO:2001141) | 1.55 | 4 | HTRA1, ERCC6, RAX2, TLR4 |
complement activation, classical pathway (GO:0006958) | 5.74 | 4 | CFI, C2, C9, C3 |
regulation of intracellular signal transduction (GO:1902531) | 2.31 | 4 | ERCC6, APOE, C3, TLR4 |
single-organism localization (GO:1902578) | 2.09 | 4 | ABCA4, FBLN5, APOE, TLR4 |
multi-organism process (GO:0051704) | 2.65 | 4 | C9, CX3CR1, APOE, TLR4 |
regulation of phosphorylation (GO:0042325) | 2.5 | 4 | ERCC6, APOE, C3, TLR4 |
regulation of phosphorus metabolic process (GO:0051174) | 2.35 | 4 | ERCC6, APOE, C3, TLR4 |
negative regulation of cellular protein metabolic process (GO:0032269) | 2.88 | 4 | CST3, APOE, C3, TLR4 |
regulation of RNA metabolic process (GO:0051252) | 1.52 | 4 | HTRA1, ERCC6, RAX2, TLR4 |
regulation of growth (GO:0040008) | 3.26 | 4 | HTRA1, APOE, C3, FBLN5 |
regulation of transcription, DNA-templated (GO:0006355) | 1.56 | 4 | HTRA1, ERCC6, RAX2, TLR4 |
regulation of macromolecule biosynthetic process (GO:0010556) | 1.43 | 4 | HTRA1, ERCC6, RAX2, TLR4 |
regulation of multicellular organismal development (GO:2000026) | 2.31 | 4 | CX3CR1, APOE, C3, TLR4 |
regulation of protein phosphorylation (GO:0001932) | 2.57 | 4 | ERCC6, APOE, C3, TLR4 |
positive regulation of cellular component organization (GO:0051130) | 2.68 | 4 | C2, APOE, C3, TLR4 |
positive regulation of multicellular organismal process (GO:0051240) | 2.49 | 4 | CX3CR1, APOE, C3, TLR4 |
protein localization (GO:0008104) | 2.36 | 3 | FBLN5, TLR4, APOE |
negative regulation of response to external stimulus (GO:0032102) | 4.18 | 3 | HTRA1, CX3CR1, APOE |
positive regulation of biosynthetic process (GO:0009891) | 2.29 | 3 | ERCC6, TLR4, APOE |
negative regulation of molecular function (GO:0044092) | 2.74 | 3 | CST3, APOE, C3 |
homeostatic process (GO:0042592) | 2.61 | 3 | ARMS2, APOE, TLR4 |
negative regulation of defense response (GO:0031348) | 4.75 | 3 | HTRA1, CX3CR1, APOE |
regulation of MAP kinase activity (GO:0043405) | 3.95 | 3 | ERCC6, APOE, TLR4 |
positive regulation of gene expression (GO:0010628) | 2.35 | 3 | ERCC6, C3, TLR4 |
positive regulation of cellular biosynthetic process (GO:0031328) | 2.3 | 3 | ERCC6, APOE, TLR4 |
cellular macromolecule biosynthetic process (GO:0034645) | 1.66 | 3 | ERCC6, APOE, RAX2 |
intracellular signal transduction (GO:0035556) | 2.39 | 3 | ERCC6, TLR4, APOE |
regulation of protein serine/threonine kinase activity (GO:0071900) | 3.58 | 3 | ERCC6, TLR4, APOE |
positive regulation of cell communication (GO:0010647) | 2.41 | 3 | ERCC6, TLR4, C3 |
organic cyclic compound metabolic process (GO:1901360) | 1.26 | 3 | ERCC6, APOE, RAX2 |
positive regulation of developmental process (GO:0051094) | 2.77 | 3 | CX3CR1, APOE, C3 |
organic substance biosynthetic process (GO:1901576) | 1.34 | 3 | ERCC6, APOE, RAX2 |
single-organism metabolic process (GO:0044710) | 1.63 | 3 | ABCA4, APOE, C3 |
negative regulation of catalytic activity (GO:0043086) | 3.0 | 3 | CST3, APOE, C3 |
regulation of cellular response to stress (GO:0080135) | 3.4 | 3 | ERCC6, FBLN5, TLR4 |
response to lipid (GO:0033993) | 3.11 | 3 | CX3CR1, TLR4, C3 |
regulation of kinase activity (GO:0043549) | 3.07 | 3 | ERCC6, TLR4, APOE |
positive regulation of protein modification process (GO:0031401) | 2.7 | 3 | ERCC6, TLR4, C3 |
interspecies interaction between organisms (GO:0044419) | 3.08 | 3 | C9, CX3CR1, APOE |
extracellular matrix organization (GO:0030198) | 4.01 | 3 | HTRA1, CST3, FBLN5 |
positive regulation of catalytic activity (GO:0043085) | 2.4 | 3 | ERCC6, TLR4, APOE |
positive regulation of molecular function (GO:0044093) | 2.23 | 3 | ERCC6, APOE, TLR4 |
extracellular structure organization (GO:0043062) | 4.0 | 3 | HTRA1, CST3, FBLN5 |
macromolecule localization (GO:0033036) | 2.34 | 3 | FBLN5, APOE, TLR4 |
G-protein coupled receptor signaling pathway (GO:0007186) | 2.64 | 3 | CX3CR1, APOE, C3 |
positive regulation of cell proliferation (GO:0008284) | 3.01 | 3 | HTRA1, CX3CR1, TLR4 |
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) | 2.35 | 3 | ERCC6, TLR4, APOE |
lipid metabolic process (GO:0006629) | 2.68 | 3 | ABCA4, APOE, C3 |
regulation of body fluid levels (GO:0050878) | 3.76 | 3 | APOE, C3, TLR4 |
response to abiotic stimulus (GO:0009628) | 2.8 | 3 | ABCA4, TLR4, ERCC6 |
regulation of protein kinase activity (GO:0045859) | 3.15 | 3 | ERCC6, APOE, TLR4 |
visual perception (GO:0007601) | 4.41 | 3 | ABCA4, HMCN1, RAX2 |
sensory perception (GO:0007600) | 2.93 | 3 | ABCA4, HMCN1, RAX2 |
sensory perception of light stimulus (GO:0050953) | 4.4 | 3 | ABCA4, HMCN1, RAX2 |
positive regulation of MAPK cascade (GO:0043410) | 3.57 | 3 | ERCC6, TLR4, C3 |
biosynthetic process (GO:0009058) | 1.32 | 3 | ERCC6, APOE, RAX2 |
multi-organism cellular process (GO:0044764) | 3.14 | 3 | C9, CX3CR1, APOE |
positive regulation of nitrogen compound metabolic process (GO:0051173) | 2.29 | 3 | ERCC6, APOE, TLR4 |
positive regulation of intracellular signal transduction (GO:1902533) | 2.95 | 3 | ERCC6, TLR4, C3 |
cellular lipid metabolic process (GO:0044255) | 2.92 | 3 | ABCA4, APOE, C3 |
macromolecule biosynthetic process (GO:0009059) | 1.61 | 3 | ERCC6, APOE, RAX2 |
response to organic substance (GO:0010033) | 2.2 | 3 | CX3CR1, TLR4, C3 |
positive regulation of signaling (GO:0023056) | 2.41 | 3 | ERCC6, C3, TLR4 |
positive regulation of phosphorylation (GO:0042327) | 2.9 | 3 | ERCC6, TLR4, C3 |
organic substance transport (GO:0071702) | 2.15 | 3 | ABCA4, TLR4, APOE |
cellular biosynthetic process (GO:0044249) | 1.37 | 3 | ERCC6, APOE, RAX2 |
anatomical structure development (GO:0048856) | 1.58 | 3 | HTRA1, TLR4, APOE |
regulation of cell differentiation (GO:0045595) | 2.42 | 3 | CX3CR1, TLR4, APOE |
regulation of transferase activity (GO:0051338) | 2.88 | 3 | ERCC6, APOE, TLR4 |
regulation of cell growth (GO:0001558) | 3.75 | 3 | HTRA1, FBLN5, APOE |
positive regulation of signal transduction (GO:0009967) | 2.5 | 3 | ERCC6, C3, TLR4 |
positive regulation of protein phosphorylation (GO:0001934) | 2.95 | 3 | ERCC6, C3, TLR4 |
regulation of synaptic plasticity (GO:0048167) | 4.78 | 2 | CX3CR1, APOE |
anatomical structure homeostasis (GO:0060249) | 4.25 | 2 | TLR4, ARMS2 |
activation of protein kinase activity (GO:0032147) | 4.08 | 2 | ERCC6, TLR4 |
positive regulation of defense response (GO:0031349) | 3.83 | 2 | TLR4, C3 |
membrane organization (GO:0061024) | 3.04 | 2 | ABCA4, APOE |
regulation of leukocyte mediated immunity (GO:0002703) | 4.7 | 2 | TLR4, C3 |
small molecule metabolic process (GO:0044281) | 2.38 | 2 | APOE, C3 |
cell surface receptor signaling pathway (GO:0007166) | 2.09 | 2 | CX3CR1, TLR4 |
organic cyclic compound biosynthetic process (GO:1901362) | 1.66 | 2 | ERCC6, RAX2 |
RNA biosynthetic process (GO:0032774) | 1.84 | 2 | ERCC6, RAX2 |
negative regulation of inflammatory response (GO:0050728) | 5.11 | 2 | CX3CR1, APOE |
positive regulation of inflammatory response (GO:0050729) | 4.98 | 2 | TLR4, C3 |
response to external biotic stimulus (GO:0043207) | 3.13 | 2 | CX3CR1, TLR4 |
cellular macromolecule localization (GO:0070727) | 3.1 | 2 | FBLN5, APOE |
cellular developmental process (GO:0048869) | 1.82 | 2 | HTRA1, TLR4 |
cell activation involved in immune response (GO:0002263) | 4.86 | 2 | CX3CR1, TLR4 |
cellular response to organic substance (GO:0071310) | 2.78 | 2 | CX3CR1, TLR4 |
negative regulation of apoptotic process (GO:0043066) | 3.04 | 2 | CX3CR1, APOE |
modification of morphology or physiology of other organism involved in symbiotic interaction (GO:0051817) | 5.27 | 2 | C9, APOE |
positive regulation of cell development (GO:0010720) | 3.57 | 2 | CX3CR1, APOE |
diterpenoid metabolic process (GO:0016101) | 5.17 | 2 | ABCA4, APOE |
regulation of apoptotic cell clearance (GO:2000425) | 7.43 | 2 | C2, C3 |
regulation of platelet activation (GO:0010543) | 6.26 | 2 | TLR4, APOE |
negative regulation of cell death (GO:0060548) | 2.95 | 2 | CX3CR1, APOE |
establishment of protein localization (GO:0045184) | 2.53 | 2 | TLR4, APOE |
positive regulation of JNK cascade (GO:0046330) | 4.98 | 2 | TLR4, ERCC6 |
cell adhesion (GO:0007155) | 2.82 | 2 | CX3CR1, FBLN5 |
response to inorganic substance (GO:0010035) | 3.56 | 2 | ERCC6, C3 |
heterocycle metabolic process (GO:0046483) | 1.31 | 2 | ERCC6, RAX2 |
negative regulation of phosphorylation (GO:0042326) | 3.7 | 2 | TLR4, APOE |
response to biotic stimulus (GO:0009607) | 3.09 | 2 | CX3CR1, TLR4 |
vesicle-mediated transport (GO:0016192) | 2.72 | 2 | CFI, APOE |
myeloid leukocyte activation (GO:0002274) | 5.15 | 2 | CX3CR1, TLR4 |
response to nutrient levels (GO:0031667) | 3.77 | 2 | C2, APOE |
cellular response to stress (GO:0033554) | 2.51 | 2 | ERCC6, APOE |
regulation of blood coagulation (GO:0030193) | 5.26 | 2 | TLR4, APOE |
aromatic compound biosynthetic process (GO:0019438) | 1.7 | 2 | ERCC6, RAX2 |
negative regulation of peptidase activity (GO:0010466) | 4.22 | 2 | CST3, C3 |
photoreceptor cell maintenance (GO:0045494) | 6.17 | 2 | ABCA4, ERCC6 |
regulation of catabolic process (GO:0009894) | 3.52 | 2 | CST3, APOE |
cellular component assembly (GO:0022607) | 2.14 | 2 | FBLN5, APOE |
positive regulation of kinase activity (GO:0033674) | 3.54 | 2 | TLR4, ERCC6 |
phospholipid transport (GO:0015914) | 5.67 | 2 | ABCA4, APOE |
response to reactive oxygen species (GO:0000302) | 4.5 | 2 | ERCC6, APOE |
leukocyte activation (GO:0045321) | 3.76 | 2 | CX3CR1, TLR4 |
regulation of vasculature development (GO:1901342) | 4.26 | 2 | CX3CR1, C3 |
nitrogen compound metabolic process (GO:0006807) | 1.13 | 2 | ERCC6, RAX2 |
regulation of JNK cascade (GO:0046328) | 4.65 | 2 | ERCC6, TLR4 |
response to lipopolysaccharide (GO:0032496) | 4.03 | 2 | CX3CR1, TLR4 |
regulation of apoptotic process (GO:0042981) | 2.5 | 2 | CX3CR1, APOE |
nucleic acid-templated transcription (GO:0097659) | 1.91 | 2 | ERCC6, RAX2 |
cellular protein metabolic process (GO:0044267) | 1.63 | 2 | CST3, TLR4 |
positive regulation of transferase activity (GO:0051347) | 3.31 | 2 | TLR4, ERCC6 |
negative regulation of hydrolase activity (GO:0051346) | 3.74 | 2 | CST3, C3 |
regulation of peptidase activity (GO:0052547) | 3.75 | 2 | CST3, C3 |
regulation of hemostasis (GO:1900046) | 5.26 | 2 | TLR4, APOE |
leukocyte activation involved in immune response (GO:0002366) | 4.88 | 2 | CX3CR1, TLR4 |
negative regulation of immune system process (GO:0002683) | 3.85 | 2 | HTRA1, TLR4 |
cellular response to molecule of bacterial origin (GO:0071219) | 4.88 | 2 | CX3CR1, TLR4 |
cellular response to biotic stimulus (GO:0071216) | 4.76 | 2 | CX3CR1, TLR4 |
heterocycle biosynthetic process (GO:0018130) | 1.7 | 2 | ERCC6, RAX2 |
response to endogenous stimulus (GO:0009719) | 2.79 | 2 | CX3CR1, C3 |
nucleobase-containing compound metabolic process (GO:0006139) | 1.35 | 2 | ERCC6, RAX2 |
regulation of viral process (GO:0050792) | 3.89 | 2 | HTRA1, APOE |
regulation of reactive oxygen species metabolic process (GO:2000377) | 4.71 | 2 | FBLN5, TLR4 |
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903) | 3.82 | 2 | HTRA1, APOE |
cell activation (GO:0001775) | 3.47 | 2 | CX3CR1, TLR4 |
single-organism membrane organization (GO:0044802) | 3.19 | 2 | ABCA4, APOE |
inflammatory response (GO:0006954) | 3.64 | 2 | TLR4, C3 |
negative regulation of intracellular signal transduction (GO:1902532) | 3.63 | 2 | TLR4, APOE |
regulation of coagulation (GO:0050818) | 5.22 | 2 | TLR4, APOE |
regulation of hydrolase activity (GO:0051336) | 2.53 | 2 | CST3, C3 |
secretion (GO:0046903) | 3.38 | 2 | TLR4, FBLN5 |
positive regulation of protein kinase activity (GO:0045860) | 3.61 | 2 | TLR4, ERCC6 |
endocytosis (GO:0006897) | 3.69 | 2 | CFI, APOE |
negative regulation of protein modification process (GO:0031400) | 3.4 | 2 | TLR4, APOE |
receptor-mediated endocytosis (GO:0006898) | 4.31 | 2 | CFI, APOE |
regulation of multi-organism process (GO:0043900) | 3.6 | 2 | HTRA1, APOE |
positive regulation of nervous system development (GO:0051962) | 3.64 | 2 | CX3CR1, APOE |
positive regulation of macromolecule biosynthetic process (GO:0010557) | 2.39 | 2 | TLR4, ERCC6 |
regulation of nervous system development (GO:0051960) | 3.1 | 2 | CX3CR1, APOE |
regulation of cell motility (GO:2000145) | 3.16 | 2 | CX3CR1, APOE |
transcription, DNA-templated (GO:0006351) | 1.91 | 2 | ERCC6, RAX2 |
negative regulation of cell motility (GO:2000146) | 4.36 | 2 | CX3CR1, APOE |
positive regulation of immune effector process (GO:0002699) | 4.69 | 2 | TLR4, C3 |
regulation of developmental growth (GO:0048638) | 4.04 | 2 | APOE, C3 |
positive regulation of response to external stimulus (GO:0032103) | 4.17 | 2 | TLR4, C3 |
lipid transport (GO:0006869) | 4.24 | 2 | ABCA4, APOE |
regulation of synapse structure or activity (GO:0050803) | 4.77 | 2 | CX3CR1, APOE |
response to radiation (GO:0009314) | 3.69 | 2 | ABCA4, ERCC6 |
negative regulation of cellular component organization (GO:0051129) | 3.35 | 2 | CST3, APOE |
modulation of synaptic transmission (GO:0050804) | 4.09 | 2 | CX3CR1, APOE |
positive regulation of MAP kinase activity (GO:0043406) | 4.39 | 2 | ERCC6, TLR4 |
cellular nitrogen compound metabolic process (GO:0034641) | 1.22 | 2 | ERCC6, RAX2 |
response to light stimulus (GO:0009416) | 4.08 | 2 | ABCA4, ERCC6 |
cellular response to chemical stimulus (GO:0070887) | 2.57 | 2 | CX3CR1, TLR4 |
anatomical structure morphogenesis (GO:0009653) | 2.53 | 2 | HTRA1, APOE |
negative regulation of MAPK cascade (GO:0043409) | 4.74 | 2 | TLR4, APOE |
positive regulation of phagocytosis (GO:0050766) | 5.9 | 2 | C2, C3 |
regulation of neurogenesis (GO:0050767) | 3.21 | 2 | CX3CR1, APOE |
regulation of phagocytosis (GO:0050764) | 5.49 | 2 | C2, C3 |
positive regulation of vasculature development (GO:1904018) | 4.83 | 2 | CX3CR1, C3 |
negative regulation of phosphorus metabolic process (GO:0010563) | 3.45 | 2 | TLR4, APOE |
regulation of cell development (GO:0060284) | 3.01 | 2 | CX3CR1, APOE |
positive regulation of neurogenesis (GO:0050769) | 3.77 | 2 | CX3CR1, APOE |
macrophage activation (GO:0042116) | 6.29 | 2 | CX3CR1, TLR4 |
positive regulation of protein serine/threonine kinase activity (GO:0071902) | 4.06 | 2 | ERCC6, TLR4 |
biological adhesion (GO:0022610) | 2.81 | 2 | CX3CR1, FBLN5 |
regulation of response to wounding (GO:1903034) | 4.74 | 2 | TLR4, APOE |
positive regulation of nucleic acid-templated transcription (GO:1903508) | 2.56 | 2 | TLR4, ERCC6 |
RNA metabolic process (GO:0016070) | 1.59 | 2 | ERCC6, RAX2 |
regulation of stress-activated protein kinase signaling cascade (GO:0070302) | 4.44 | 2 | TLR4, ERCC6 |
cellular nitrogen compound biosynthetic process (GO:0044271) | 1.59 | 2 | ERCC6, RAX2 |
cellular response to lipid (GO:0071396) | 3.96 | 2 | CX3CR1, TLR4 |
negative regulation of cellular component movement (GO:0051271) | 4.22 | 2 | CX3CR1, APOE |
positive regulation of stress-activated protein kinase signaling cascade (GO:0070304) | 4.82 | 2 | TLR4, ERCC6 |
regulation of vesicle-mediated transport (GO:0060627) | 3.63 | 2 | C2, C3 |
positive regulation of cell differentiation (GO:0045597) | 3.01 | 2 | CX3CR1, APOE |
negative regulation of cell differentiation (GO:0045596) | 3.33 | 2 | TLR4, APOE |
regulation of cellular component movement (GO:0051270) | 3.08 | 2 | CX3CR1, APOE |
positive regulation of transcription, DNA-templated (GO:0045893) | 2.56 | 2 | ERCC6, TLR4 |
positive regulation of stress-activated MAPK cascade (GO:0032874) | 4.82 | 2 | TLR4, ERCC6 |
positive regulation of apoptotic cell clearance (GO:2000427) | 7.78 | 2 | C2, C3 |
detection of stimulus (GO:0051606) | 3.22 | 2 | ABCA4, TLR4 |
tissue homeostasis (GO:0001894) | 4.78 | 2 | TLR4, ARMS2 |
response to oxidative stress (GO:0006979) | 3.9 | 2 | ERCC6, APOE |
regulation of epithelial cell proliferation (GO:0050678) | 4.06 | 2 | HTRA1, APOE |
positive regulation of RNA metabolic process (GO:0051254) | 2.51 | 2 | TLR4, ERCC6 |
positive regulation of RNA biosynthetic process (GO:1902680) | 2.54 | 2 | TLR4, ERCC6 |
regulation of cytokine production (GO:0001817) | 3.4 | 2 | TLR4, C3 |
response to molecule of bacterial origin (GO:0002237) | 3.99 | 2 | CX3CR1, TLR4 |
positive regulation of proteolysis (GO:0045862) | 3.86 | 2 | APOE, C3 |
negative regulation of proteolysis (GO:0045861) | 3.98 | 2 | CST3, C3 |
positive regulation of ERK1 and ERK2 cascade (GO:0070374) | 4.56 | 2 | TLR4, C3 |
regulation of ERK1 and ERK2 cascade (GO:0070372) | 4.23 | 2 | TLR4, C3 |
positive regulation of cytokine production (GO:0001819) | 3.82 | 2 | TLR4, C3 |
activation of MAPK activity (GO:0000187) | 4.79 | 2 | TLR4, ERCC6 |
response to extracellular stimulus (GO:0009991) | 3.71 | 2 | C2, APOE |
cellular response to lipopolysaccharide (GO:0071222) | 4.94 | 2 | CX3CR1, TLR4 |
regulation of cellular catabolic process (GO:0031329) | 3.83 | 2 | CST3, APOE |
regulation of cell activation (GO:0050865) | 3.53 | 2 | TLR4, APOE |
apoptotic signaling pathway (GO:0097190) | 4.12 | 2 | ERCC6, TLR4 |
nucleic acid metabolic process (GO:0090304) | 1.46 | 2 | ERCC6, RAX2 |
regulation of wound healing (GO:0061041) | 4.88 | 2 | TLR4, APOE |
regulation of lipid biosynthetic process (GO:0046890) | 4.87 | 2 | APOE, C3 |
regulation of cell death (GO:0010941) | 2.43 | 2 | CX3CR1, APOE |
retinoid metabolic process (GO:0001523) | 5.25 | 2 | ABCA4, APOE |
regulation of angiogenesis (GO:0045765) | 4.36 | 2 | CX3CR1, C3 |
positive regulation of angiogenesis (GO:0045766) | 4.93 | 2 | CX3CR1, C3 |
terpenoid metabolic process (GO:0006721) | 5.07 | 2 | ABCA4, APOE |
regulation of programmed cell death (GO:0043067) | 2.49 | 2 | CX3CR1, APOE |
regulation of transcription from RNA polymerase II promoter (GO:0006357) | 2.24 | 2 | HTRA1, TLR4 |
negative regulation of phosphate metabolic process (GO:0045936) | 3.45 | 2 | TLR4, APOE |
isoprenoid metabolic process (GO:0006720) | 4.89 | 2 | ABCA4, APOE |
negative regulation of programmed cell death (GO:0043069) | 3.02 | 2 | CX3CR1, APOE |
negative regulation of cell migration (GO:0030336) | 4.41 | 2 | CX3CR1, APOE |
regulation of cell migration (GO:0030334) | 3.23 | 2 | CX3CR1, APOE |
regulation of lipid metabolic process (GO:0019216) | 4.08 | 2 | APOE, C3 |
regulation of endopeptidase activity (GO:0052548) | 3.8 | 2 | CST3, C3 |
cellular aromatic compound metabolic process (GO:0006725) | 1.3 | 2 | ERCC6, RAX2 |
cellular protein localization (GO:0034613) | 3.11 | 2 | FBLN5, APOE |
regulation of stress-activated MAPK cascade (GO:0032872) | 4.45 | 2 | TLR4, ERCC6 |
negative regulation of endopeptidase activity (GO:0010951) | 4.26 | 2 | CST3, C3 |
regulation of endocytosis (GO:0030100) | 4.42 | 2 | C2, C3 |
negative regulation of protein phosphorylation (GO:0001933) | 3.79 | 2 | TLR4, APOE |
cellular localization (GO:0051641) | 2.32 | 2 | FBLN5, APOE |
cellular response to oxygen-containing compound (GO:1901701) | 3.22 | 2 | CX3CR1, TLR4 |
negative regulation of locomotion (GO:0040013) | 4.22 | 2 | CX3CR1, APOE |
regulation of locomotion (GO:0040012) | 3.12 | 2 | CX3CR1, APOE |
regulation of cellular component biogenesis (GO:0044087) | 3.08 | 2 | TLR4, APOE |
viral process (GO:0016032) | 3.15 | 2 | CX3CR1, APOE |
organophosphate ester transport (GO:0015748) | 5.33 | 2 | ABCA4, APOE |
protein transport (GO:0015031) | 2.62 | 2 | TLR4, APOE |
symbiosis, encompassing mutualism through parasitism (GO:0044403) | 3.15 | 2 | CX3CR1, APOE |
positive regulation of endocytosis (GO:0045807) | 4.98 | 2 | C2, C3 |
nucleobase-containing compound biosynthetic process (GO:0034654) | 1.72 | 2 | ERCC6, RAX2 |
modification of morphology or physiology of other organism (GO:0035821) | 5.12 | 2 | C9, APOE |
positive regulation of cellular component biogenesis (GO:0044089) | 3.71 | 2 | TLR4, APOE |