Disease table of MACULAR DEGENERATION, AGE-RELATED OMIM ID: PS603075

Gene-disease associations table

GeneAssociated with MACULAR DEGENERATION, AGE-RELATED inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CFHR3OMIMHGNC link1q31.32PS235400, PS603075
RAX2ClinVar, OMIM, HUMSAVARHGNC link19p13.32PS603075, 610381
APOEOMIMHGNC link19q13.325PS603075, 608516, 104310, 611771, 269600
CFHClinVar, OMIM, HUMSAVARHGNC link1q31.34PS235400, 126700, 609814, PS603075
CX3CR1ClinVar, OMIMHGNC link3p22.23607339, PS603075, 609423
CFIOMIM, HUMSAVARHGNC link4q253PS235400, 610984, PS603075
CFBClinVar, OMIMHGNC link6p21.333PS235400, 615561, PS603075
ARMS2ClinVar, OMIMHGNC link10q26.131PS603075
C9ClinVar, OMIM, HUMSAVARHGNC link5p13.12613825, PS603075
ERCC6ClinVar, OMIMHGNC link10q11.236211980, PS603075, 133540, PS600630, PS214150, 278800
ABCA4ClinVar, OMIM, HUMSAVARHGNC link1p22.14248200, PS268000, 604116, PS603075
CFHR1OMIMHGNC link1q31.32PS235400, PS603075
TLR4OMIMHGNC link9q33.12114500, PS603075
CST3ClinVar, OMIM, HUMSAVARHGNC link20p11.212105150, PS603075
C3OMIM, HUMSAVARHGNC link19p13.33PS235400, 613779, PS603075
C2ClinVar, OMIMHGNC link6p21.332217000, PS603075
HMCN1OMIM, HUMSAVARHGNC link1q25.31PS603075
HTRA1ClinVar, OMIMHGNC link10q26.133616779, PS603075, 600142
FBLN5ClinVar, OMIM, HUMSAVARHGNC link14q32.124PS603075, 123700, 219100, 614434

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 862CFHR3, CFHR1
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
19p13.32RAX2, C3
10q26.132ARMS2, HTRA1
1q31.33CFH, CFHR3, CFHR1
6p21.332C2, CFB
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
19p132RAX2, C3
1q313CFH, CFHR3, CFHR1
6p212C2, CFB
10q262ARMS2, HTRA1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
1q33CFH, CFHR3, CFHR1
6p22C2, CFB
10q22ARMS2, HTRA1
19p12RAX2, C3
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1q4CFH, HMCN1, CFHR3, CFHR1
19p2RAX2, C3
6p2C2, CFB
10q3ERCC6, ARMS2, HTRA1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
103ERCC6, ARMS2, HTRA1
193RAX2, APOE, C3
15CFH, ABCA4, CFHR3, HMCN1, CFHR1
62C2, CFB
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
APOEYES4SP1, ATF4, NR1H3, FOXM10
CFHYES1SIRT10
CFIYES2NFKB1, RELA0
CFBYES2STAT3, CREB50
TLR4YES4ZNF160, SPI1, IRF3, IRF80
C3YES1CEBPD0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CFHR3CFHNo1C3
CFHR3CFINo1C3
CFHR3CFBNo1C3
CFHR3CFHR1No1PRDX4
CFHR3C3Yes0
APOECFHNo1ALB
APOECFBNo1ALB
APOECST3No1ALB
APOEHTRA1Yes2NOS3, APOE
CFHCFINo1C3
CFHCFBNo2ALB, C3
CFHTLR4No1SMAD3
CFHCST3No1ALB
CFHC3Yes0
CFICFBNo1C3
CFIC3Yes0
CFBC9No2LAMTOR5, FN1
CFBCST3No1ALB
CFBC3Yes4DDX19B, GDPD1, CFP, FN1
C9C3No1FN1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
APOETLR4No-3IL6, HSP90B1, TLR2
APOECST3No-2APOA1, APOA4
APOEFBLN5No-1TGFB1
CX3CR1TLR4No-3IL8, JAK2, CXCL10
ARMS2HMCN1Yesbinding0
ERCC6TLR4No-1UBC
TLR4HTRA1Yesactivation, binding3BIRC2, EGFR, BIRC3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
CFHCFBNo1C3
CFHC3Yes2CFH, C3
CFBC3Yes3CFD, CFB, C3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Complement and coagulation cascadeshsa046106.586CFI, C2, C3, CFH, CFB, C9
Staphylococcus aureus infectionhsa051506.645CFI, C2, CFB, C3, CFH
Pertussishsa051336.463C2, TLR4, C3
Systemic lupus erythematosushsa053225.953C2, C9, C3
Legionellosishsa051346.882TLR4, C3
Chagas disease (American trypanosomiasis)hsa051425.992TLR4, C3
Leishmaniasishsa051406.322TLR4, C3
Amoebiasishsa051465.822C9, TLR4
Tuberculosishsa051525.172TLR4, C3
Phagosomehsa041455.272TLR4, C3

NET-GE enrichment

Term New enriched termICP valueGenes
Pertussis (hsa05133) -6.460.009CFI, C2, TLR4, C3
Complement and coagulation cascades (hsa04610) -6.580.0CFI, C2, C3, CFH, CFB, CST3, C9
Systemic lupus erythematosus (hsa05322) -5.950.043C2, C9, C3
Staphylococcus aureus infection (hsa05150) -6.640.0CFI, C2, CFB, C3, CFH
Immune systemNEW2.920.001CFI, CX3CR1, APOE, C9, C2, C3, CFH, CFB, CST3, TLR4
Infectious diseases: BacterialNEW3.760.005CFI, C2, C3, CFH, CFB, TLR4
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Innate Immune SystemR-HSA-1682493.178CFI, C9, C3, CFH, CFB, CFHR3, C2, TLR4
Immune SystemR-HSA-1682562.378CFI, C9, C3, CFH, CFB, CFHR3, C2, TLR4
Regulation of Complement cascadeR-HSA-9776068.47CFI, C9, C3, CFH, CFB, CFHR3, C2
Complement cascadeR-HSA-1666585.387CFI, C9, C3, CFH, CFB, CFHR3, C2
Signal TransductionR-HSA-1625821.784CX3CR1, ABCA4, APOE, C3
Initial triggering of complementR-HSA-1666635.513C2, CFB, C3
Activation of C3 and C5R-HSA-17457710.183C2, CFB, C3
DiseaseR-HSA-16436853.333CST3, ABCA4, TLR4
Visual phototransductionR-HSA-21873386.442ABCA4, APOE
Signaling by GPCRR-HSA-3727902.682CX3CR1, C3
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.692CX3CR1, C3
Peptide ligand-binding receptorsR-HSA-3752765.412CX3CR1, C3
Alternative complement activationR-HSA-17373610.662CFB, C3
GPCR ligand bindingR-HSA-5007924.192CX3CR1, C3

NET-GE enrichment

Term New enriched termICP valueGenes
Regulation of Complement cascade (R-HSA-977606) -8.40.0CFI, C9, C3, CFH, CFB, CFHR3, C2
Innate Immune System (R-HSA-168249) -3.170.003CFI, C9, C3, CFH, CFB, CFHR3, C2, TLR4
Alternative complement activation (R-HSA-173736) -10.660.003CFB, C3
Complement cascade (R-HSA-166658) -5.380.0CFI, C9, C3, CFH, CFB, CST3, CFHR3, C2
Activation of C3 and C5 (R-HSA-174577) -10.180.0C2, CFB, C3
Initial triggering of complement (R-HSA-166663) -5.510.031C2, CFB, C3, CST3
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1815CFI, CX3CR1, RAX2, APOE, HTRA1, ERCC6, C2, HMCN1, C3, FBLN5, CFH, CFB, CST3, ABCA4, TLR4
protein binding (GO:0005515) 0.4611CFI, CX3CR1, ERCC6, APOE, HTRA1, CST3, C3, FBLN5, CFH, CFB, TLR4
hydrolase activity (GO:0016787) 1.97CFI, CFB, HTRA1, ABCA4, C3, ERCC6, C2
catalytic activity (GO:0003824) 1.057CFI, CFB, HTRA1, ABCA4, C3, ERCC6, C2
serine-type endopeptidase activity (GO:0004252) 4.45HTRA1, CFI, C2, CFB, C3
endopeptidase activity (GO:0004175) 3.635HTRA1, CFI, C2, CFB, C3
serine hydrolase activity (GO:0017171) 4.265HTRA1, CFI, C2, CFB, C3
carbohydrate derivative binding (GO:0097367) 2.035ABCA4, ERCC6, TLR4, APOE, CFH
cation binding (GO:0043169) 1.45FBLN5, CFI, C2, HMCN1, APOE
ion binding (GO:0043167) 1.365FBLN5, CFI, C2, HMCN1, APOE
peptidase activity, acting on L-amino acid peptides (GO:0070011) 3.265HTRA1, CFI, C2, CFB, C3
peptidase activity (GO:0008233) 3.235HTRA1, CFI, C2, CFB, C3
metal ion binding (GO:0046872) 1.415FBLN5, CFI, C2, HMCN1, APOE
serine-type peptidase activity (GO:0008236) 4.275HTRA1, CFI, C2, CFB, C3
organic cyclic compound binding (GO:0097159) 1.054ABCA4, ERCC6, APOE, RAX2
enzyme regulator activity (GO:0030234) 2.854CST3, ERCC6, APOE, C3
molecular function regulator (GO:0098772) 2.514CST3, ERCC6, APOE, C3
lipid binding (GO:0008289) 3.263APOE, C3, TLR4
small molecule binding (GO:0036094) 1.893ABCA4, ERCC6, APOE
molecular transducer activity (GO:0060089) 2.323CFI, CX3CR1, TLR4
macromolecular complex binding (GO:0044877) 2.613FBLN5, ERCC6, APOE
receptor activity (GO:0004872) 2.323CFI, CX3CR1, TLR4
receptor binding (GO:0005102) 2.433FBLN5, APOE, C3
heterocyclic compound binding (GO:1901363) 1.063ABCA4, ERCC6, RAX2
identical protein binding (GO:0042802) 2.633CST3, FBLN5, APOE
protein C-terminus binding (GO:0008022) 4.52ERCC6, FBLN5
signaling receptor activity (GO:0038023) 2.492CX3CR1, TLR4
peptidase inhibitor activity (GO:0030414) 4.552CST3, C3
purine ribonucleoside triphosphate binding (GO:0035639) 2.222ABCA4, ERCC6
signal transducer activity (GO:0004871) 2.282CX3CR1, TLR4
enzyme activator activity (GO:0008047) 3.562ERCC6, APOE
ATPase activity (GO:0016887) 3.652ABCA4, ERCC6
DNA binding (GO:0003677) 1.922ERCC6, RAX2
nucleic acid binding (GO:0003676) 1.442ERCC6, RAX2
enzyme inhibitor activity (GO:0004857) 3.782CST3, C3
purine nucleoside binding (GO:0001883) 2.222ABCA4, ERCC6
nucleoside phosphate binding (GO:1901265) 1.962ABCA4, ERCC6
nucleoside binding (GO:0001882) 2.212ABCA4, ERCC6
sulfur compound binding (GO:1901681) 4.322CFH, APOE
peptide binding (GO:0042277) 4.222CST3, APOE
ATPase activity, coupled (GO:0042623) 3.972ABCA4, ERCC6
transporter activity (GO:0005215) 2.572ABCA4, APOE
nucleotide binding (GO:0000166) 1.962ABCA4, ERCC6
calcium ion binding (GO:0005509) 3.172HMCN1, FBLN5
ribonucleoside binding (GO:0032549) 2.222ABCA4, ERCC6
protein complex binding (GO:0032403) 3.092FBLN5, ERCC6
purine nucleotide binding (GO:0017076) 2.192ABCA4, ERCC6
ATP binding (GO:0005524) 2.432ABCA4, ERCC6
protein homodimerization activity (GO:0042803) 3.162FBLN5, APOE
lipid transporter activity (GO:0005319) 5.032ABCA4, APOE
amide binding (GO:0033218) 4.142CST3, APOE
endopeptidase regulator activity (GO:0061135) 4.572CST3, C3
peptidase regulator activity (GO:0061134) 4.372CST3, C3
nucleoside-triphosphatase activity (GO:0017111) 3.092ABCA4, ERCC6
endopeptidase inhibitor activity (GO:0004866) 4.62CST3, C3
beta-amyloid binding (GO:0001540) 6.212CST3, APOE
heparin binding (GO:0008201) 4.682CFH, APOE
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032ABCA4, ERCC6
substrate-specific transporter activity (GO:0022892) 2.722ABCA4, APOE
adenyl nucleotide binding (GO:0030554) 2.42ABCA4, ERCC6
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032ABCA4, ERCC6
glycosaminoglycan binding (GO:0005539) 4.422CFH, APOE
pyrophosphatase activity (GO:0016462) 3.042ABCA4, ERCC6
transmembrane signaling receptor activity (GO:0004888) 2.572CX3CR1, TLR4
adenyl ribonucleotide binding (GO:0032559) 2.412ABCA4, ERCC6
ribonucleotide binding (GO:0032553) 2.192ABCA4, ERCC6
purine ribonucleotide binding (GO:0032555) 2.22ABCA4, ERCC6
protein dimerization activity (GO:0046983) 2.722FBLN5, APOE
purine ribonucleoside binding (GO:0032550) 2.222ABCA4, ERCC6
transmembrane receptor activity (GO:0099600) 2.532CX3CR1, TLR4

NET-GE enrichment

Term New enriched termICP valueGenes
serine-type endopeptidase activity (GO:0004252) -4.40.005HTRA1, CFI, C2, CFB, C3
serine hydrolase activity (GO:0017171) -4.260.0CFI, APOE, HTRA1, C2, C3, CFB
beta-amyloid binding (GO:0001540) -6.210.035CST3, APOE
serine-type peptidase activity (GO:0008236) -4.270.0CFI, APOE, HTRA1, C2, C3, CFB
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
biological regulation (GO:0065007) 0.3917CFI, CX3CR1, RAX2, APOE, C2, HTRA1, ABCA4, CFHR1, C3, FBLN5, CFH, ERCC6, TLR4, CFB, CST3, C9, ARMS2
regulation of biological process (GO:0050789) 0.4516CFI, CX3CR1, ERCC6, RAX2, C2, HTRA1, C9, CFHR1, C3, FBLN5, CFH, CFB, CST3, APOE, ABCA4, TLR4
response to stimulus (GO:0050896) 1.2215CFI, CX3CR1, ERCC6, RAX2, C2, C9, CFHR1, HMCN1, C3, CFH, CFB, CST3, APOE, ABCA4, TLR4
primary metabolic process (GO:0044238) 0.6914CFI, ERCC6, RAX2, APOE, C2, HTRA1, ABCA4, CFHR1, C3, CFH, CFB, CST3, C9, TLR4
metabolic process (GO:0008152) 0.5814CFI, ERCC6, RAX2, APOE, C2, HTRA1, ABCA4, CFHR1, C3, CFH, CFB, CST3, C9, TLR4
organic substance metabolic process (GO:0071704) 0.6314CFI, ERCC6, RAX2, APOE, C2, HTRA1, ABCA4, CFHR1, C3, CFH, CFB, CST3, C9, TLR4
regulation of response to stimulus (GO:0048583) 1.5413CFI, CX3CR1, CFB, APOE, HTRA1, C9, CFHR1, C3, FBLN5, CFH, ERCC6, C2, TLR4
regulation of metabolic process (GO:0019222) 1.0213CFI, ERCC6, APOE, HTRA1, RAX2, C2, C3, FBLN5, CFH, CFB, CST3, C9, TLR4
macromolecule metabolic process (GO:0043170) 0.8313CFI, CFB, RAX2, HTRA1, C9, CFHR1, C3, CFH, ERCC6, CST3, APOE, C2, TLR4
positive regulation of biological process (GO:0048518) 1.212CFI, CX3CR1, CFB, APOE, HTRA1, C9, CFHR1, C3, CFH, ERCC6, C2, TLR4
regulation of macromolecule metabolic process (GO:0060255) 1.0812CFI, ERCC6, APOE, HTRA1, RAX2, C2, C3, CFH, CFB, CST3, C9, TLR4
regulation of response to stress (GO:0080134) 2.5312CFI, CX3CR1, ERCC6, APOE, HTRA1, C9, C3, FBLN5, CFH, CFB, C2, TLR4
regulation of primary metabolic process (GO:0080090) 1.0812CFI, ERCC6, APOE, HTRA1, RAX2, C2, C3, CFH, CFB, CST3, C9, TLR4
response to stress (GO:0006950) 1.811CFI, CX3CR1, ERCC6, APOE, C9, C3, CFH, CFB, CST3, C2, TLR4
cellular process (GO:0009987) 0.2611CX3CR1, RAX2, APOE, HTRA1, ABCA4, C3, FBLN5, ERCC6, CST3, C9, TLR4
regulation of gene expression (GO:0010468) 1.3711CFI, ERCC6, APOE, HTRA1, RAX2, C2, C3, CFH, CFB, C9, TLR4
regulation of cellular process (GO:0050794) 0.511CX3CR1, RAX2, APOE, HTRA1, ABCA4, C2, C3, FBLN5, ERCC6, CST3, TLR4
protein metabolic process (GO:0019538) 1.4510CFI, HTRA1, C9, CFHR1, C3, CFH, CFB, CST3, C2, TLR4
regulation of protein metabolic process (GO:0051246) 1.9310CFI, CFB, APOE, C9, C2, C3, CFH, ERCC6, CST3, TLR4
regulation of defense response (GO:0031347) 3.1110CFI, CX3CR1, APOE, HTRA1, C9, C3, CFH, CFB, C2, TLR4
regulation of response to external stimulus (GO:0032101) 3.0610CFI, CX3CR1, APOE, HTRA1, C9, C3, CFH, CFB, C2, TLR4
defense response (GO:0006952) 2.789CFI, CX3CR1, C9, C3, CFH, CFB, CST3, C2, TLR4
positive regulation of response to stimulus (GO:0048584) 2.189CFI, CFB, C9, CFHR1, C3, CFH, ERCC6, C2, TLR4
regulation of inflammatory response (GO:0050727) 4.039CFI, CX3CR1, APOE, C9, C3, CFH, CFB, C2, TLR4
immune system process (GO:0002376) 2.299CFI, CX3CR1, C9, CFHR1, C3, CFH, CFB, C2, TLR4
regulation of immune system process (GO:0002682) 2.59CFI, HTRA1, C9, CFHR1, C3, CFH, CFB, C2, TLR4
immune effector process (GO:0002252) 3.589CFI, CX3CR1, C9, CFHR1, C3, CFH, CFB, C2, TLR4
single-organism process (GO:0044699) 0.489CX3CR1, FBLN5, APOE, HTRA1, ABCA4, C3, ERCC6, CST3, TLR4
regulation of immune response (GO:0050776) 2.988CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4
regulation of cellular metabolic process (GO:0031323) 1.078RAX2, APOE, HTRA1, CST3, C3, FBLN5, ERCC6, TLR4
regulation of immune effector process (GO:0002697) 3.718CFI, HTRA1, C9, C3, CFH, CFB, C2, TLR4
positive regulation of immune response (GO:0050778) 3.48CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4
positive regulation of immune system process (GO:0002684) 2.968CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4
multicellular organismal process (GO:0032501) 1.458CX3CR1, RAX2, APOE, ABCA4, C3, HMCN1, ERCC6, TLR4
single-organism cellular process (GO:0044763) 0.658CX3CR1, APOE, HTRA1, CST3, C3, FBLN5, ABCA4, TLR4
activation of immune response (GO:0002253) 3.678CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4
immune response (GO:0006955) 2.868CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4
regulation of proteolysis (GO:0030162) 3.28CFI, APOE, C2, C3, CFH, CFB, CST3, C9
regulation of biological quality (GO:0065008) 1.687CX3CR1, APOE, ABCA4, C3, ARMS2, C9, TLR4
protein activation cascade (GO:0072376) 5.217CFI, C9, CFHR1, C3, CFH, CFB, C2
innate immune response (GO:0045087) 3.557CFI, C9, C3, CFH, CFB, C2, TLR4
cellular metabolic process (GO:0044237) 0.697RAX2, APOE, ABCA4, C3, ERCC6, CST3, TLR4
regulation of cellular component organization (GO:0051128) 2.017APOE, HTRA1, CST3, C3, FBLN5, C2, TLR4
complement activation (GO:0006956) 5.497CFI, C9, CFHR1, C3, CFH, CFB, C2
humoral immune response (GO:0006959) 4.597CFI, C9, CFHR1, C3, CFH, CFB, C2
positive regulation of cellular process (GO:0048522) 1.37CX3CR1, APOE, HTRA1, C2, C3, ERCC6, TLR4
regulation of protein processing (GO:0070613) 5.356CFI, C2, C3, CFH, CFB, C9
regulation of complement activation (GO:0030449) 6.236CFI, C2, C3, CFH, CFB, C9
single-multicellular organism process (GO:0044707) 1.786CX3CR1, APOE, ABCA4, C3, ERCC6, TLR4
regulation of signal transduction (GO:0009966) 1.846CX3CR1, APOE, HTRA1, C3, ERCC6, TLR4
regulation of cellular biosynthetic process (GO:0031326) 1.386RAX2, APOE, HTRA1, C3, ERCC6, TLR4
regulation of signaling (GO:0023051) 1.726CX3CR1, APOE, HTRA1, C3, ERCC6, TLR4
regulation of biosynthetic process (GO:0009889) 1.376RAX2, APOE, HTRA1, C3, ERCC6, TLR4
regulation of protein activation cascade (GO:2000257) 6.176CFI, C2, C3, CFH, CFB, C9
regulation of humoral immune response (GO:0002920) 5.826CFI, C2, C3, CFH, CFB, C9
signal transduction (GO:0007165) 1.286CX3CR1, APOE, ABCA4, C3, ERCC6, TLR4
negative regulation of biological process (GO:0048519) 1.336CX3CR1, APOE, HTRA1, CST3, C3, TLR4
regulation of acute inflammatory response (GO:0002673) 5.416CFI, C2, C3, CFH, CFB, C9
response to chemical (GO:0042221) 1.986CX3CR1, APOE, C2, C3, ERCC6, TLR4
regulation of protein maturation (GO:1903317) 5.336CFI, C2, C3, CFH, CFB, C9
regulation of cell communication (GO:0010646) 1.736CX3CR1, APOE, HTRA1, C3, ERCC6, TLR4
negative regulation of cellular process (GO:0048523) 1.416CX3CR1, APOE, HTRA1, CST3, C3, TLR4
system process (GO:0003008) 2.36CX3CR1, RAX2, APOE, ABCA4, HMCN1, TLR4
response to oxygen-containing compound (GO:1901700) 2.575CX3CR1, ERCC6, APOE, C3, TLR4
transport (GO:0006810) 1.515FBLN5, CFI, ABCA4, TLR4, APOE
cellular macromolecule metabolic process (GO:0044260) 0.935ERCC6, CST3, APOE, RAX2, TLR4
response to external stimulus (GO:0009605) 2.555CX3CR1, C2, ABCA4, APOE, TLR4
regulation of molecular function (GO:0065009) 1.785CST3, ERCC6, APOE, C3, TLR4
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.435APOE, HTRA1, ERCC6, RAX2, TLR4
regulation of catalytic activity (GO:0050790) 1.975CST3, ERCC6, APOE, C3, TLR4
cellular component organization (GO:0016043) 1.245HTRA1, CST3, ABCA4, APOE, FBLN5
regulation of developmental process (GO:0050793) 2.15CX3CR1, CST3, APOE, C3, TLR4
regulation of cellular protein metabolic process (GO:0032268) 1.995CST3, ERCC6, APOE, C3, TLR4
regulation of nitrogen compound metabolic process (GO:0051171) 1.365APOE, HTRA1, ERCC6, RAX2, TLR4
regulation of multicellular organismal process (GO:0051239) 1.875CX3CR1, CST3, APOE, C3, TLR4
proteolysis (GO:0006508) 2.735HTRA1, CFI, C2, CFB, C3
regulation of localization (GO:0032879) 1.945CX3CR1, C2, APOE, C3, TLR4
establishment of localization (GO:0051234) 1.485FBLN5, CFI, ABCA4, TLR4, APOE
localization (GO:0051179) 1.45FBLN5, CFI, ABCA4, TLR4, APOE
cellular component organization or biogenesis (GO:0071840) 1.225HTRA1, CST3, ABCA4, APOE, FBLN5
developmental process (GO:0032502) 1.364HTRA1, APOE, ERCC6, TLR4
negative regulation of metabolic process (GO:0009892) 1.934CST3, APOE, C3, TLR4
positive regulation of metabolic process (GO:0009893) 1.744ERCC6, APOE, C3, TLR4
regulation of anatomical structure morphogenesis (GO:0022603) 2.794CX3CR1, CST3, APOE, C3
regulation of transport (GO:0051049) 2.244C2, APOE, C3, TLR4
negative regulation of response to stimulus (GO:0048585) 2.524HTRA1, CX3CR1, TLR4, APOE
negative regulation of cellular metabolic process (GO:0031324) 2.014CST3, APOE, C3, TLR4
negative regulation of signaling (GO:0023057) 2.654HTRA1, CX3CR1, TLR4, APOE
negative regulation of cell communication (GO:0010648) 2.664HTRA1, CX3CR1, APOE, TLR4
regulation of phosphate metabolic process (GO:0019220) 2.354ERCC6, APOE, C3, TLR4
regulation of MAPK cascade (GO:0043408) 3.224ERCC6, APOE, C3, TLR4
cellular response to stimulus (GO:0051716) 1.974CX3CR1, ERCC6, APOE, TLR4
negative regulation of macromolecule metabolic process (GO:0010605) 2.014CST3, APOE, C3, TLR4
positive regulation of macromolecule metabolic process (GO:0010604) 1.814ERCC6, APOE, C3, TLR4
negative regulation of signal transduction (GO:0009968) 2.754HTRA1, CX3CR1, TLR4, APOE
positive regulation of phosphorus metabolic process (GO:0010562) 2.784ERCC6, APOE, C3, TLR4
negative regulation of multicellular organismal process (GO:0051241) 2.844CST3, CX3CR1, APOE, TLR4
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464HTRA1, ERCC6, RAX2, TLR4
positive regulation of protein metabolic process (GO:0051247) 2.434ERCC6, APOE, C3, TLR4
positive regulation of cellular protein metabolic process (GO:0032270) 2.494ERCC6, APOE, C3, TLR4
regulation of protein modification process (GO:0031399) 2.324ERCC6, APOE, C3, TLR4
positive regulation of cellular metabolic process (GO:0031325) 1.814ERCC6, APOE, C3, TLR4
regulation of cell proliferation (GO:0042127) 2.414HTRA1, CX3CR1, TLR4, APOE
negative regulation of developmental process (GO:0051093) 3.174CST3, CX3CR1, APOE, TLR4
positive regulation of phosphate metabolic process (GO:0045937) 2.784ERCC6, APOE, C3, TLR4
positive regulation of transport (GO:0051050) 2.94C2, APOE, C3, TLR4
neurological system process (GO:0050877) 2.644CX3CR1, HMCN1, ABCA4, RAX2
negative regulation of protein metabolic process (GO:0051248) 2.824CST3, APOE, C3, TLR4
regulation of nucleic acid-templated transcription (GO:1903506) 1.554HTRA1, ERCC6, RAX2, TLR4
single-organism developmental process (GO:0044767) 1.494HTRA1, ERCC6, APOE, TLR4
single-organism transport (GO:0044765) 2.184ABCA4, FBLN5, APOE, TLR4
complement activation, alternative pathway (GO:0006957) 7.164C9, CFB, C3, CFH
regulation of RNA biosynthetic process (GO:2001141) 1.554HTRA1, ERCC6, RAX2, TLR4
complement activation, classical pathway (GO:0006958) 5.744CFI, C2, C9, C3
regulation of intracellular signal transduction (GO:1902531) 2.314ERCC6, APOE, C3, TLR4
single-organism localization (GO:1902578) 2.094ABCA4, FBLN5, APOE, TLR4
multi-organism process (GO:0051704) 2.654C9, CX3CR1, APOE, TLR4
regulation of phosphorylation (GO:0042325) 2.54ERCC6, APOE, C3, TLR4
regulation of phosphorus metabolic process (GO:0051174) 2.354ERCC6, APOE, C3, TLR4
negative regulation of cellular protein metabolic process (GO:0032269) 2.884CST3, APOE, C3, TLR4
regulation of RNA metabolic process (GO:0051252) 1.524HTRA1, ERCC6, RAX2, TLR4
regulation of growth (GO:0040008) 3.264HTRA1, APOE, C3, FBLN5
regulation of transcription, DNA-templated (GO:0006355) 1.564HTRA1, ERCC6, RAX2, TLR4
regulation of macromolecule biosynthetic process (GO:0010556) 1.434HTRA1, ERCC6, RAX2, TLR4
regulation of multicellular organismal development (GO:2000026) 2.314CX3CR1, APOE, C3, TLR4
regulation of protein phosphorylation (GO:0001932) 2.574ERCC6, APOE, C3, TLR4
positive regulation of cellular component organization (GO:0051130) 2.684C2, APOE, C3, TLR4
positive regulation of multicellular organismal process (GO:0051240) 2.494CX3CR1, APOE, C3, TLR4
protein localization (GO:0008104) 2.363FBLN5, TLR4, APOE
negative regulation of response to external stimulus (GO:0032102) 4.183HTRA1, CX3CR1, APOE
positive regulation of biosynthetic process (GO:0009891) 2.293ERCC6, TLR4, APOE
negative regulation of molecular function (GO:0044092) 2.743CST3, APOE, C3
homeostatic process (GO:0042592) 2.613ARMS2, APOE, TLR4
negative regulation of defense response (GO:0031348) 4.753HTRA1, CX3CR1, APOE
regulation of MAP kinase activity (GO:0043405) 3.953ERCC6, APOE, TLR4
positive regulation of gene expression (GO:0010628) 2.353ERCC6, C3, TLR4
positive regulation of cellular biosynthetic process (GO:0031328) 2.33ERCC6, APOE, TLR4
cellular macromolecule biosynthetic process (GO:0034645) 1.663ERCC6, APOE, RAX2
intracellular signal transduction (GO:0035556) 2.393ERCC6, TLR4, APOE
regulation of protein serine/threonine kinase activity (GO:0071900) 3.583ERCC6, TLR4, APOE
positive regulation of cell communication (GO:0010647) 2.413ERCC6, TLR4, C3
organic cyclic compound metabolic process (GO:1901360) 1.263ERCC6, APOE, RAX2
positive regulation of developmental process (GO:0051094) 2.773CX3CR1, APOE, C3
organic substance biosynthetic process (GO:1901576) 1.343ERCC6, APOE, RAX2
single-organism metabolic process (GO:0044710) 1.633ABCA4, APOE, C3
negative regulation of catalytic activity (GO:0043086) 3.03CST3, APOE, C3
regulation of cellular response to stress (GO:0080135) 3.43ERCC6, FBLN5, TLR4
response to lipid (GO:0033993) 3.113CX3CR1, TLR4, C3
regulation of kinase activity (GO:0043549) 3.073ERCC6, TLR4, APOE
positive regulation of protein modification process (GO:0031401) 2.73ERCC6, TLR4, C3
interspecies interaction between organisms (GO:0044419) 3.083C9, CX3CR1, APOE
extracellular matrix organization (GO:0030198) 4.013HTRA1, CST3, FBLN5
positive regulation of catalytic activity (GO:0043085) 2.43ERCC6, TLR4, APOE
positive regulation of molecular function (GO:0044093) 2.233ERCC6, APOE, TLR4
extracellular structure organization (GO:0043062) 4.03HTRA1, CST3, FBLN5
macromolecule localization (GO:0033036) 2.343FBLN5, APOE, TLR4
G-protein coupled receptor signaling pathway (GO:0007186) 2.643CX3CR1, APOE, C3
positive regulation of cell proliferation (GO:0008284) 3.013HTRA1, CX3CR1, TLR4
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353ERCC6, TLR4, APOE
lipid metabolic process (GO:0006629) 2.683ABCA4, APOE, C3
regulation of body fluid levels (GO:0050878) 3.763APOE, C3, TLR4
response to abiotic stimulus (GO:0009628) 2.83ABCA4, TLR4, ERCC6
regulation of protein kinase activity (GO:0045859) 3.153ERCC6, APOE, TLR4
visual perception (GO:0007601) 4.413ABCA4, HMCN1, RAX2
sensory perception (GO:0007600) 2.933ABCA4, HMCN1, RAX2
sensory perception of light stimulus (GO:0050953) 4.43ABCA4, HMCN1, RAX2
positive regulation of MAPK cascade (GO:0043410) 3.573ERCC6, TLR4, C3
biosynthetic process (GO:0009058) 1.323ERCC6, APOE, RAX2
multi-organism cellular process (GO:0044764) 3.143C9, CX3CR1, APOE
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293ERCC6, APOE, TLR4
positive regulation of intracellular signal transduction (GO:1902533) 2.953ERCC6, TLR4, C3
cellular lipid metabolic process (GO:0044255) 2.923ABCA4, APOE, C3
macromolecule biosynthetic process (GO:0009059) 1.613ERCC6, APOE, RAX2
response to organic substance (GO:0010033) 2.23CX3CR1, TLR4, C3
positive regulation of signaling (GO:0023056) 2.413ERCC6, C3, TLR4
positive regulation of phosphorylation (GO:0042327) 2.93ERCC6, TLR4, C3
organic substance transport (GO:0071702) 2.153ABCA4, TLR4, APOE
cellular biosynthetic process (GO:0044249) 1.373ERCC6, APOE, RAX2
anatomical structure development (GO:0048856) 1.583HTRA1, TLR4, APOE
regulation of cell differentiation (GO:0045595) 2.423CX3CR1, TLR4, APOE
regulation of transferase activity (GO:0051338) 2.883ERCC6, APOE, TLR4
regulation of cell growth (GO:0001558) 3.753HTRA1, FBLN5, APOE
positive regulation of signal transduction (GO:0009967) 2.53ERCC6, C3, TLR4
positive regulation of protein phosphorylation (GO:0001934) 2.953ERCC6, C3, TLR4
regulation of synaptic plasticity (GO:0048167) 4.782CX3CR1, APOE
anatomical structure homeostasis (GO:0060249) 4.252TLR4, ARMS2
activation of protein kinase activity (GO:0032147) 4.082ERCC6, TLR4
positive regulation of defense response (GO:0031349) 3.832TLR4, C3
membrane organization (GO:0061024) 3.042ABCA4, APOE
regulation of leukocyte mediated immunity (GO:0002703) 4.72TLR4, C3
small molecule metabolic process (GO:0044281) 2.382APOE, C3
cell surface receptor signaling pathway (GO:0007166) 2.092CX3CR1, TLR4
organic cyclic compound biosynthetic process (GO:1901362) 1.662ERCC6, RAX2
RNA biosynthetic process (GO:0032774) 1.842ERCC6, RAX2
negative regulation of inflammatory response (GO:0050728) 5.112CX3CR1, APOE
positive regulation of inflammatory response (GO:0050729) 4.982TLR4, C3
response to external biotic stimulus (GO:0043207) 3.132CX3CR1, TLR4
cellular macromolecule localization (GO:0070727) 3.12FBLN5, APOE
cellular developmental process (GO:0048869) 1.822HTRA1, TLR4
cell activation involved in immune response (GO:0002263) 4.862CX3CR1, TLR4
cellular response to organic substance (GO:0071310) 2.782CX3CR1, TLR4
negative regulation of apoptotic process (GO:0043066) 3.042CX3CR1, APOE
modification of morphology or physiology of other organism involved in symbiotic interaction (GO:0051817) 5.272C9, APOE
positive regulation of cell development (GO:0010720) 3.572CX3CR1, APOE
diterpenoid metabolic process (GO:0016101) 5.172ABCA4, APOE
regulation of apoptotic cell clearance (GO:2000425) 7.432C2, C3
regulation of platelet activation (GO:0010543) 6.262TLR4, APOE
negative regulation of cell death (GO:0060548) 2.952CX3CR1, APOE
establishment of protein localization (GO:0045184) 2.532TLR4, APOE
positive regulation of JNK cascade (GO:0046330) 4.982TLR4, ERCC6
cell adhesion (GO:0007155) 2.822CX3CR1, FBLN5
response to inorganic substance (GO:0010035) 3.562ERCC6, C3
heterocycle metabolic process (GO:0046483) 1.312ERCC6, RAX2
negative regulation of phosphorylation (GO:0042326) 3.72TLR4, APOE
response to biotic stimulus (GO:0009607) 3.092CX3CR1, TLR4
vesicle-mediated transport (GO:0016192) 2.722CFI, APOE
myeloid leukocyte activation (GO:0002274) 5.152CX3CR1, TLR4
response to nutrient levels (GO:0031667) 3.772C2, APOE
cellular response to stress (GO:0033554) 2.512ERCC6, APOE
regulation of blood coagulation (GO:0030193) 5.262TLR4, APOE
aromatic compound biosynthetic process (GO:0019438) 1.72ERCC6, RAX2
negative regulation of peptidase activity (GO:0010466) 4.222CST3, C3
photoreceptor cell maintenance (GO:0045494) 6.172ABCA4, ERCC6
regulation of catabolic process (GO:0009894) 3.522CST3, APOE
cellular component assembly (GO:0022607) 2.142FBLN5, APOE
positive regulation of kinase activity (GO:0033674) 3.542TLR4, ERCC6
phospholipid transport (GO:0015914) 5.672ABCA4, APOE
response to reactive oxygen species (GO:0000302) 4.52ERCC6, APOE
leukocyte activation (GO:0045321) 3.762CX3CR1, TLR4
regulation of vasculature development (GO:1901342) 4.262CX3CR1, C3
nitrogen compound metabolic process (GO:0006807) 1.132ERCC6, RAX2
regulation of JNK cascade (GO:0046328) 4.652ERCC6, TLR4
response to lipopolysaccharide (GO:0032496) 4.032CX3CR1, TLR4
regulation of apoptotic process (GO:0042981) 2.52CX3CR1, APOE
nucleic acid-templated transcription (GO:0097659) 1.912ERCC6, RAX2
cellular protein metabolic process (GO:0044267) 1.632CST3, TLR4
positive regulation of transferase activity (GO:0051347) 3.312TLR4, ERCC6
negative regulation of hydrolase activity (GO:0051346) 3.742CST3, C3
regulation of peptidase activity (GO:0052547) 3.752CST3, C3
regulation of hemostasis (GO:1900046) 5.262TLR4, APOE
leukocyte activation involved in immune response (GO:0002366) 4.882CX3CR1, TLR4
negative regulation of immune system process (GO:0002683) 3.852HTRA1, TLR4
cellular response to molecule of bacterial origin (GO:0071219) 4.882CX3CR1, TLR4
cellular response to biotic stimulus (GO:0071216) 4.762CX3CR1, TLR4
heterocycle biosynthetic process (GO:0018130) 1.72ERCC6, RAX2
response to endogenous stimulus (GO:0009719) 2.792CX3CR1, C3
nucleobase-containing compound metabolic process (GO:0006139) 1.352ERCC6, RAX2
regulation of viral process (GO:0050792) 3.892HTRA1, APOE
regulation of reactive oxygen species metabolic process (GO:2000377) 4.712FBLN5, TLR4
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903) 3.822HTRA1, APOE
cell activation (GO:0001775) 3.472CX3CR1, TLR4
single-organism membrane organization (GO:0044802) 3.192ABCA4, APOE
inflammatory response (GO:0006954) 3.642TLR4, C3
negative regulation of intracellular signal transduction (GO:1902532) 3.632TLR4, APOE
regulation of coagulation (GO:0050818) 5.222TLR4, APOE
regulation of hydrolase activity (GO:0051336) 2.532CST3, C3
secretion (GO:0046903) 3.382TLR4, FBLN5
positive regulation of protein kinase activity (GO:0045860) 3.612TLR4, ERCC6
endocytosis (GO:0006897) 3.692CFI, APOE
negative regulation of protein modification process (GO:0031400) 3.42TLR4, APOE
receptor-mediated endocytosis (GO:0006898) 4.312CFI, APOE
regulation of multi-organism process (GO:0043900) 3.62HTRA1, APOE
positive regulation of nervous system development (GO:0051962) 3.642CX3CR1, APOE
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392TLR4, ERCC6
regulation of nervous system development (GO:0051960) 3.12CX3CR1, APOE
regulation of cell motility (GO:2000145) 3.162CX3CR1, APOE
transcription, DNA-templated (GO:0006351) 1.912ERCC6, RAX2
negative regulation of cell motility (GO:2000146) 4.362CX3CR1, APOE
positive regulation of immune effector process (GO:0002699) 4.692TLR4, C3
regulation of developmental growth (GO:0048638) 4.042APOE, C3
positive regulation of response to external stimulus (GO:0032103) 4.172TLR4, C3
lipid transport (GO:0006869) 4.242ABCA4, APOE
regulation of synapse structure or activity (GO:0050803) 4.772CX3CR1, APOE
response to radiation (GO:0009314) 3.692ABCA4, ERCC6
negative regulation of cellular component organization (GO:0051129) 3.352CST3, APOE
modulation of synaptic transmission (GO:0050804) 4.092CX3CR1, APOE
positive regulation of MAP kinase activity (GO:0043406) 4.392ERCC6, TLR4
cellular nitrogen compound metabolic process (GO:0034641) 1.222ERCC6, RAX2
response to light stimulus (GO:0009416) 4.082ABCA4, ERCC6
cellular response to chemical stimulus (GO:0070887) 2.572CX3CR1, TLR4
anatomical structure morphogenesis (GO:0009653) 2.532HTRA1, APOE
negative regulation of MAPK cascade (GO:0043409) 4.742TLR4, APOE
positive regulation of phagocytosis (GO:0050766) 5.92C2, C3
regulation of neurogenesis (GO:0050767) 3.212CX3CR1, APOE
regulation of phagocytosis (GO:0050764) 5.492C2, C3
positive regulation of vasculature development (GO:1904018) 4.832CX3CR1, C3
negative regulation of phosphorus metabolic process (GO:0010563) 3.452TLR4, APOE
regulation of cell development (GO:0060284) 3.012CX3CR1, APOE
positive regulation of neurogenesis (GO:0050769) 3.772CX3CR1, APOE
macrophage activation (GO:0042116) 6.292CX3CR1, TLR4
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.062ERCC6, TLR4
biological adhesion (GO:0022610) 2.812CX3CR1, FBLN5
regulation of response to wounding (GO:1903034) 4.742TLR4, APOE
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562TLR4, ERCC6
RNA metabolic process (GO:0016070) 1.592ERCC6, RAX2
regulation of stress-activated protein kinase signaling cascade (GO:0070302) 4.442TLR4, ERCC6
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592ERCC6, RAX2
cellular response to lipid (GO:0071396) 3.962CX3CR1, TLR4
negative regulation of cellular component movement (GO:0051271) 4.222CX3CR1, APOE
positive regulation of stress-activated protein kinase signaling cascade (GO:0070304) 4.822TLR4, ERCC6
regulation of vesicle-mediated transport (GO:0060627) 3.632C2, C3
positive regulation of cell differentiation (GO:0045597) 3.012CX3CR1, APOE
negative regulation of cell differentiation (GO:0045596) 3.332TLR4, APOE
regulation of cellular component movement (GO:0051270) 3.082CX3CR1, APOE
positive regulation of transcription, DNA-templated (GO:0045893) 2.562ERCC6, TLR4
positive regulation of stress-activated MAPK cascade (GO:0032874) 4.822TLR4, ERCC6
positive regulation of apoptotic cell clearance (GO:2000427) 7.782C2, C3
detection of stimulus (GO:0051606) 3.222ABCA4, TLR4
tissue homeostasis (GO:0001894) 4.782TLR4, ARMS2
response to oxidative stress (GO:0006979) 3.92ERCC6, APOE
regulation of epithelial cell proliferation (GO:0050678) 4.062HTRA1, APOE
positive regulation of RNA metabolic process (GO:0051254) 2.512TLR4, ERCC6
positive regulation of RNA biosynthetic process (GO:1902680) 2.542TLR4, ERCC6
regulation of cytokine production (GO:0001817) 3.42TLR4, C3
response to molecule of bacterial origin (GO:0002237) 3.992CX3CR1, TLR4
positive regulation of proteolysis (GO:0045862) 3.862APOE, C3
negative regulation of proteolysis (GO:0045861) 3.982CST3, C3
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562TLR4, C3
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232TLR4, C3
positive regulation of cytokine production (GO:0001819) 3.822TLR4, C3
activation of MAPK activity (GO:0000187) 4.792TLR4, ERCC6
response to extracellular stimulus (GO:0009991) 3.712C2, APOE
cellular response to lipopolysaccharide (GO:0071222) 4.942CX3CR1, TLR4
regulation of cellular catabolic process (GO:0031329) 3.832CST3, APOE
regulation of cell activation (GO:0050865) 3.532TLR4, APOE
apoptotic signaling pathway (GO:0097190) 4.122ERCC6, TLR4
nucleic acid metabolic process (GO:0090304) 1.462ERCC6, RAX2
regulation of wound healing (GO:0061041) 4.882TLR4, APOE
regulation of lipid biosynthetic process (GO:0046890) 4.872APOE, C3
regulation of cell death (GO:0010941) 2.432CX3CR1, APOE
retinoid metabolic process (GO:0001523) 5.252ABCA4, APOE
regulation of angiogenesis (GO:0045765) 4.362CX3CR1, C3
positive regulation of angiogenesis (GO:0045766) 4.932CX3CR1, C3
terpenoid metabolic process (GO:0006721) 5.072ABCA4, APOE
regulation of programmed cell death (GO:0043067) 2.492CX3CR1, APOE
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242HTRA1, TLR4
negative regulation of phosphate metabolic process (GO:0045936) 3.452TLR4, APOE
isoprenoid metabolic process (GO:0006720) 4.892ABCA4, APOE
negative regulation of programmed cell death (GO:0043069) 3.022CX3CR1, APOE
negative regulation of cell migration (GO:0030336) 4.412CX3CR1, APOE
regulation of cell migration (GO:0030334) 3.232CX3CR1, APOE
regulation of lipid metabolic process (GO:0019216) 4.082APOE, C3
regulation of endopeptidase activity (GO:0052548) 3.82CST3, C3
cellular aromatic compound metabolic process (GO:0006725) 1.32ERCC6, RAX2
cellular protein localization (GO:0034613) 3.112FBLN5, APOE
regulation of stress-activated MAPK cascade (GO:0032872) 4.452TLR4, ERCC6
negative regulation of endopeptidase activity (GO:0010951) 4.262CST3, C3
regulation of endocytosis (GO:0030100) 4.422C2, C3
negative regulation of protein phosphorylation (GO:0001933) 3.792TLR4, APOE
cellular localization (GO:0051641) 2.322FBLN5, APOE
cellular response to oxygen-containing compound (GO:1901701) 3.222CX3CR1, TLR4
negative regulation of locomotion (GO:0040013) 4.222CX3CR1, APOE
regulation of locomotion (GO:0040012) 3.122CX3CR1, APOE
regulation of cellular component biogenesis (GO:0044087) 3.082TLR4, APOE
viral process (GO:0016032) 3.152CX3CR1, APOE
organophosphate ester transport (GO:0015748) 5.332ABCA4, APOE
protein transport (GO:0015031) 2.622TLR4, APOE
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152CX3CR1, APOE
positive regulation of endocytosis (GO:0045807) 4.982C2, C3
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722ERCC6, RAX2
modification of morphology or physiology of other organism (GO:0035821) 5.122C9, APOE
positive regulation of cellular component biogenesis (GO:0044089) 3.712TLR4, APOE

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of complement activation (GO:0030449) -6.230.0CFI, C2, C3, CFH, CFB, C9
regulation of response to external stimulus (GO:0032101) -3.060.008CFI, APOE, ABCA4, C2, C3, CFH, CFB, CST3, C9, TLR4
positive regulation of response to stimulus (GO:0048584) -2.180.01CFI, CFB, C9, CFHR1, C3, CFH, ERCC6, C2, TLR4
regulation of response to stimulus (GO:0048583) -1.540.0CFI, CX3CR1, CFB, APOE, HTRA1, C9, CFHR1, C3, FBLN5, CFH, ERCC6, C2, TLR4
regulation of humoral immune response (GO:0002920) -5.820.0CFI, C2, C3, CFH, CFB, C9
regulation of defense response (GO:0031347) -3.110.0CFI, APOE, C9, C3, CFH, CFB, CST3, C2, TLR4
regulation of phagocytosis (GO:0050764) -5.490.027CFI, C2, TLR4, C3
protein activation cascade (GO:0072376) -5.210.0CFI, C2, C9, CFHR1, C3, CFH, CFB, CST3
regulation of protein metabolic process (GO:0051246) -1.930.005CFI, CFB, APOE, C9, C3, CFH, ERCC6, CST3, C2, TLR4
regulation of inflammatory response (GO:0050727) -4.030.0CFI, APOE, C9, C3, CFH, CFB, CST3, C2, TLR4
positive regulation of immune system process (GO:0002684) -2.960.015CFI, APOE, C2, C9, CFHR1, C3, CFH, CFB, CST3, TLR4
regulation of immune system process (GO:0002682) -2.50.018CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4
positive regulation of apoptotic cell clearance (GO:2000427) -7.780.015C2, C3
regulation of response to wounding (GO:1903034) -4.740.001CFI, APOE, C9, C2, C3, CFH, CFB, CST3, TLR4
regulation of activation of membrane attack complex (GO:0001969) NEW8.630.01C9, C3
innate immune response (GO:0045087) -3.550.006CFI, C9, C3, CFH, CFB, C2, TLR4
regulation of protein activation cascade (GO:2000257) -6.170.0CFI, C9, C2, C3, CFH, CFB, CST3
defense response (GO:0006952) -2.780.001CFI, CX3CR1, C9, C2, C3, CFH, CFB, CST3, TLR4
response to stress (GO:0006950) -1.80.012CFI, CX3CR1, ERCC6, APOE, C9, C2, C3, CFH, CFB, CST3, TLR4
regulation of protein processing (GO:0070613) -5.350.0CFI, APOE, CST3, C2, C3, CFH, CFB, C9
complement activation (GO:0006956) -5.490.0CFI, C9, CFHR1, C3, CFH, CFB, CST3, C2
complement activation, alternative pathway (GO:0006957) -7.160.0C9, CFB, C3, CFH
immune response (GO:0006955) -2.860.008CFI, C9, CFHR1, C3, CFH, CFB, C2, TLR4
regulation of acute inflammatory response (GO:0002673) -5.410.0CFI, C2, C3, CFH, CFB, C9
complement activation, classical pathway (GO:0006958) -5.740.003CFI, CST3, C2, C9, C3
humoral immune response (GO:0006959) -4.590.0CFI, C2, C9, CFHR1, C3, CFH, CFB, CST3
regulation of endocytosis (GO:0030100) -4.420.033CFI, APOE, C2, C3, CST3, TLR4
regulation of immune response (GO:0050776) -2.980.022CFI, APOE, C9, CFHR1, C3, CFH, CFB, CST3, C2, TLR4
regulation of response to stress (GO:0080134) -2.530.022CFI, CFB, APOE, C9, C2, C3, FBLN5, CFH, ERCC6, CST3, TLR4
positive regulation of immune response (GO:0050778) -3.40.0CFI, C2, C9, CFHR1, C3, CFH, CFB, CST3, TLR4
immune system process (GO:0002376) -2.290.027CFI, CX3CR1, C9, CFHR1, C3, CFH, CFB, C2, TLR4
regulation of immune effector process (GO:0002697) -3.710.0CFI, APOE, C9, C2, C3, CFH, CFB, CST3, TLR4
activation of immune response (GO:0002253) -3.670.0CFI, C9, CFHR1, C3, CFH, CFB, CST3, C2, TLR4
immune effector process (GO:0002252) -3.580.0CFI, CX3CR1, C9, CFHR1, C3, CFH, CFB, CST3, C2, TLR4
regulation of protein maturation (GO:1903317) -5.330.0CFI, APOE, C2, C3, CFH, CFB, CST3, C9
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
membrane-bounded organelle (GO:0043227) 0.4717CFI, ERCC6, RAX2, C2, HTRA1, ABCA4, CFHR1, HMCN1, C3, FBLN5, CFH, CFB, CST3, APOE, CFHR3, C9, ARMS2
organelle (GO:0043226) 0.417CFI, ERCC6, RAX2, C2, HTRA1, ABCA4, CFHR1, HMCN1, C3, FBLN5, CFH, CFB, CST3, APOE, CFHR3, C9, ARMS2
extracellular organelle (GO:0043230) 1.8913CFI, FBLN5, APOE, C2, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CFHR3, CST3
extracellular exosome (GO:0070062) 1.8913CFI, FBLN5, APOE, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CST3, CFHR3, C2
membrane-bounded vesicle (GO:0031988) 1.7113CFI, FBLN5, APOE, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CST3, CFHR3, C2
extracellular region (GO:0005576) 2.1813CFI, FBLN5, APOE, C2, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CFHR3, CST3
extracellular vesicle (GO:1903561) 1.8913CFI, FBLN5, APOE, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CST3, CFHR3, C2
extracellular region part (GO:0044421) 1.5713CFI, FBLN5, APOE, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CST3, CFHR3, C2
vesicle (GO:0031982) 1.6413CFI, FBLN5, APOE, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CST3, CFHR3, C2
cell part (GO:0044464) 0.1112CX3CR1, RAX2, APOE, HTRA1, C9, C3, HMCN1, ERCC6, TLR4, CFB, ABCA4, ARMS2
extracellular space (GO:0005615) 2.6311CFI, FBLN5, APOE, HTRA1, CST3, CFHR1, C3, CFH, CFB, CFHR3, C2
intracellular part (GO:0044424) 0.2810CX3CR1, RAX2, APOE, HTRA1, ABCA4, HMCN1, TLR4, ERCC6, C9, ARMS2
membrane (GO:0016020) 0.689CFI, CX3CR1, APOE, HTRA1, ABCA4, C3, CFB, C9, TLR4
blood microparticle (GO:0072562) 4.887APOE, C9, CFHR1, C3, CFH, CFB, CFHR3
plasma membrane (GO:0005886) 1.397CX3CR1, APOE, HTRA1, C9, C3, CFB, TLR4
cytoplasm (GO:0005737) 1.016APOE, HTRA1, C9, HMCN1, TLR4, ARMS2
cytoplasmic part (GO:0044444) 0.826CX3CR1, APOE, HTRA1, HMCN1, TLR4, ARMS2
intracellular organelle (GO:0043229) 0.515ARMS2, ABCA4, ERCC6, APOE, RAX2
intracellular membrane-bounded organelle (GO:0043231) 0.65ARMS2, ABCA4, ERCC6, APOE, RAX2
extracellular matrix (GO:0031012) 3.815HTRA1, CST3, HMCN1, APOE, FBLN5
macromolecular complex (GO:0032991) 1.354C9, ERCC6, APOE, TLR4
plasma membrane part (GO:0044459) 1.954CX3CR1, ABCA4, C9, TLR4
integral component of membrane (GO:0016021) 1.144CX3CR1, ABCA4, C9, TLR4
neuron part (GO:0097458) 2.644CX3CR1, ABCA4, ARMS2, APOE
organelle part (GO:0044422) 0.794ABCA4, ERCC6, APOE, TLR4
integral component of plasma membrane (GO:0005887) 2.574CX3CR1, ABCA4, C9, TLR4
membrane part (GO:0044425) 0.954CX3CR1, C9, ABCA4, TLR4
intrinsic component of plasma membrane (GO:0031226) 2.534CX3CR1, ABCA4, C9, TLR4
intrinsic component of membrane (GO:0031224) 1.134CX3CR1, C9, ABCA4, TLR4
protein complex (GO:0043234) 1.513C9, TLR4, ERCC6
intracellular organelle part (GO:0044446) 0.813ERCC6, TLR4, APOE
nucleus (GO:0005634) 1.073ERCC6, APOE, RAX2
cell projection (GO:0042995) 2.473ABCA4, CX3CR1, APOE
organelle membrane (GO:0031090) 1.972ABCA4, TLR4
bounding membrane of organelle (GO:0098588) 2.392ABCA4, TLR4
membrane protein complex (GO:0098796) 2.842C9, TLR4
neuron projection (GO:0043005) 3.122CX3CR1, APOE
perinuclear region of cytoplasm (GO:0048471) 3.352CX3CR1, TLR4
extracellular matrix component (GO:0044420) 4.972HMCN1, FBLN5
proteinaceous extracellular matrix (GO:0005578) 4.012HMCN1, FBLN5

NET-GE enrichment

Term New enriched termICP valueGenes
extracellular organelle (GO:0043230) -1.890.0CFI, FBLN5, APOE, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CST3, CFHR3, C2
extracellular space (GO:0005615) -2.630.0CFI, FBLN5, APOE, HTRA1, C9, CFHR1, C3, CFH, CFB, CST3, CFHR3, C2, TLR4
extracellular vesicular exosome (GO:0070062) -1.890.0CFI, FBLN5, APOE, C2, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CFHR3, CST3
blood microparticle (GO:0072562) -4.880.0CFI, APOE, C9, CFHR1, C3, CFH, CFB, CST3, CFHR3, C2
membrane-bounded vesicle (GO:0031988) -1.710.0CFI, FBLN5, APOE, C2, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CFHR3, CST3
extracellular matrix part (GO:0044420) -4.970.028CST3, HMCN1, FBLN5
extracellular region (GO:0005576) -2.180.033CFI, FBLN5, APOE, HTRA1, C9, C2, C3, CFH, CFB, CST3, TLR4
extracellular membrane-bounded organelle (GO:0065010) NEW8.70.0CFI, FBLN5, APOE, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CST3, CFHR3, C2
extracellular region part (GO:0044421) -1.570.0CFI, FBLN5, APOE, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CST3, CFHR3, C2
vesicle (GO:0031982) -1.640.0CFI, FBLN5, APOE, C2, HTRA1, C9, CFHR1, HMCN1, C3, CFH, CFB, CFHR3, CST3