Disease table of LEFT VENTRICULAR NONCOMPACTION OMIM ID: PS604169

Gene-disease associations table

GeneAssociated with LEFT VENTRICULAR NONCOMPACTION inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PRDM16ClinVar, OMIM, HUMSAVARHGNC link1p36.322PS604169, PS115200
TNNT2ClinVar, OMIM, HUMSAVARHGNC link1q32.15PS192600, PS604169, 218040, PS115200, PS115210
MYH7ClinVar, OMIM, HUMSAVARHGNC link14q11.29PS192600, 160500, PS604169, PS115200, 603829, 255310, 255160, 608358, 181430
ACTC1ClinVar, OMIM, HUMSAVARHGNC link15q144PS108800, PS192600, PS115200, PS604169
MIB1ClinVar, OMIM, HUMSAVARHGNC link18q11.21PS604169
TPM1ClinVar, OMIM, HUMSAVARHGNC link15q22.24PS604169, PS604772, PS115200, PS192600
LDB3ClinVar, OMIM, HUMSAVARHGNC link10q23.24PS604169, PS192600, PS601419, PS115200
MYBPC3ClinVar, OMIM, HUMSAVARHGNC link11p11.24PS604169, PS604772, PS115200, PS192600
DTNAClinVar, OMIM, HUMSAVARHGNC link18q12.11PS604169

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
18q12DTNA, MIB1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
15q2ACTC1, TPM1
18q2DTNA, MIB1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
152ACTC1, TPM1
182DTNA, MIB1
12PRDM16, TNNT2
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
ACTC1YES1YY10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TNNT2MYH7No1TNNI1
TNNT2ACTC1No1TPM1
TNNT2TPM1Yes2TPM1, TNNI1
MYH7TPM1No6ACTN2, TNNI1, KXD1, RBPJ, YWHAQ, TPM2
MYH7LDB3No1ACTN2
ACTC1MIB1No1DAPK1
ACTC1TPM1Yes4SP1, TPM1, PAN2, ACTA2
ACTC1MYBPC3No3CAPN1, TNNI3K, HSPB2
MIB1TPM1No1UBC
TPM1LDB3No2ACTN2, ATP5F1
TPM1DTNANo1SEC23A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TNNT2MYH7Yesbinding18ACTN2, MYL1, MYH6, MYL2, TNNC1, MYH8, TNNI1, MYH14, MYH3, TNNI3, TNNT3, TNNC2, TPM3, TPM1, MYBPC3, TNNI2, TPM2, MYL3
TNNT2ACTC1No-15TPM1, MYH6, MYH7, TNNC1, MYH8, TPM3, TNNI3, MYH14, TNNC2, MYH3, MYL2, TPM4, MYL4, TPM2, MYL3
TNNT2MIB1No-1DLL4
TNNT2TPM1Yesbinding28TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
TNNT2LDB3No-1ACTN2
TNNT2MYBPC3Yesbinding28TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC1, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
TNNT2DTNANo-1ACTN2
MYH7ACTC1Yesbinding18TPM1, MYH11, MYL3, MYL2, TPM2, MYH4, MYH2, MYH14, MYH3, TNNI3, TNNC1, MYH1, TNNC2, TPM3, MYH6, MYH10, MYH8, MYH9
MYH7TPM1Yesbinding27MYH8, TNNT3, TPM3, MYL6B, MYBPC3, TPM2, MYL1, MYH11, MYL3, ACTA1, MYH1, MYH14, TNNC2, ACTG2, MYH6, ACTA2, ACTC1, TNNI3, MYL9, TNNT2, MYL12B, ACTN2, MYL2, TNNC1, TNNI1, MYH3, TNNI2
MYH7LDB3No-1ACTN2
MYH7MYBPC3Yesbinding30TPM1, TNNI1, MYH8, MYOM1, MYH9, TPM3, MYL6B, TPM2, MYLPF, MYL1, MYH11, MYH6, MYH1, MYH14, TNNC2, MYL5, MYH2, MYH4, TNNI3, MYL9, TNNT2, MYL3, ACTN2, MYL2, TNNC1, MYH13, TNNT3, MYH3, TNNI2, MYH10
MYH7DTNANo-1ACTN2
ACTC1MIB1No-1UBC
ACTC1TPM1Yesbinding20TPM2, CFL1, MYH11, MYH6, MYH7, TNNC1, MYL4, TPM3, MYH1, MYH3, TNNI3, MYH14, MYL2, UBC, DSTN, TPM4, ACTN4, MYH8, TNNC2, MYL3
ACTC1LDB3No-1ACTN4
ACTC1MYBPC3No-21TPM4, TPM1, MYH11, MYH6, MYH2, TNNC1, MYL4, TPM2, TPM3, MYH14, MYH3, TNNI3, MYH9, TNNC2, MYH8, MYH1, MYH7, MYH10, MYH4, MYL2, MYL3
ACTC1DTNANo-0
MIB1TPM1No-1UBC
TPM1LDB3No-3ACTN2, ACTN4, ACTN1
TPM1MYBPC3Yesbinding32TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYH1, MYL6B, TPM2, MYL1, MYH11, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYL9, MYH7, TNNT2, MYBPC1, ACTN2, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
TPM1DTNANo-1ACTN2
LDB3MYBPC3No-1ACTN2
LDB3DTNANo-2ACTN2, DLG5
MYBPC3DTNANo-1ACTN2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ACTC1TPM1Yes1ACTA2
TPM1DTNANo1SEC23A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Hypertrophic cardiomyopathy (HCM)hsa054106.215TNNT2, MYBPC3, ACTC1, TPM1, MYH7
Dilated cardiomyopathyhsa054146.085TNNT2, MYBPC3, ACTC1, TPM1, MYH7
Cardiac muscle contractionhsa042606.344TNNT2, TPM1, ACTC1, MYH7
Adrenergic signaling in cardiomyocyteshsa042615.444TNNT2, TPM1, ACTC1, MYH7

NET-GE enrichment

Term New enriched termICP valueGenes
Cardiovascular diseasesNEW5.060.0TNNT2, MYBPC3, ACTC1, TPM1, MYH7
Dilated cardiomyopathy (hsa05414) -6.080.0TNNT2, MYBPC3, ACTC1, TPM1, MYH7
Circulatory systemNEW4.630.0TNNT2, TPM1, ACTC1, MYH7
Hypertrophic cardiomyopathy (HCM) (hsa05410) -6.210.0TNNT2, MYBPC3, ACTC1, TPM1, MYH7
Cardiac muscle contraction (hsa04260) -6.340.0TNNT2, TPM1, ACTC1, MYH7
Adrenergic signaling in cardiomyocytes (hsa04261) -5.440.0TNNT2, TPM1, ACTC1, MYH7
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Muscle contractionR-HSA-3970146.964TNNT2, MYBPC3, ACTC1, TPM1
Striated Muscle ContractionR-HSA-3905227.814TNNT2, MYBPC3, ACTC1, TPM1

NET-GE enrichment

Term New enriched termICP valueGenes
Muscle contraction (R-HSA-397014) -6.960.0TNNT2, MYBPC3, ACTC1, TPM1
Striated Muscle Contraction (R-HSA-390522) -7.810.0TNNT2, MYBPC3, ACTC1, TPM1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.189TPM1, TNNT2, LDB3, MYH7, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
protein binding (GO:0005515) 0.469TPM1, TNNT2, LDB3, MYH7, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
cytoskeletal protein binding (GO:0008092) 3.026TPM1, TNNT2, MYH7, ACTC1, LDB3, MYBPC3
catalytic activity (GO:0003824) 1.055TNNT2, MIB1, ACTC1, MYH7, PRDM16
ion binding (GO:0043167) 1.365MIB1, MYBPC3, DTNA, LDB3, PRDM16
metal ion binding (GO:0046872) 1.415MIB1, MYBPC3, DTNA, LDB3, PRDM16
cation binding (GO:0043169) 1.45MIB1, MYBPC3, DTNA, LDB3, PRDM16
actin binding (GO:0003779) 3.744MYBPC3, TNNT2, TPM1, MYH7
hydrolase activity (GO:0016787) 1.93TNNT2, ACTC1, MYH7
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.033TNNT2, ACTC1, MYH7
transition metal ion binding (GO:0046914) 2.483MIB1, DTNA, LDB3
organic cyclic compound binding (GO:0097159) 1.053ACTC1, MYH7, PRDM16
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.033TNNT2, ACTC1, MYH7
nucleoside-triphosphatase activity (GO:0017111) 3.093TNNT2, ACTC1, MYH7
pyrophosphatase activity (GO:0016462) 3.043TNNT2, ACTC1, MYH7
zinc ion binding (GO:0008270) 2.663MIB1, DTNA, LDB3
ATPase activity (GO:0016887) 3.653TNNT2, ACTC1, MYH7
heterocyclic compound binding (GO:1901363) 1.063ACTC1, MYH7, PRDM16
adenyl nucleotide binding (GO:0030554) 2.42ACTC1, MYH7
carbohydrate derivative binding (GO:0097367) 2.032ACTC1, MYH7
purine ribonucleoside triphosphate binding (GO:0035639) 2.222ACTC1, MYH7
structural constituent of muscle (GO:0008307) 6.022MYBPC3, TPM1
myosin binding (GO:0017022) 5.662MYBPC3, ACTC1
nucleotide binding (GO:0000166) 1.962ACTC1, MYH7
small molecule binding (GO:0036094) 1.892ACTC1, MYH7
ribonucleotide binding (GO:0032553) 2.192ACTC1, MYH7
transferase activity (GO:0016740) 1.952MIB1, PRDM16
identical protein binding (GO:0042802) 2.632MYBPC3, MYH7
adenyl ribonucleotide binding (GO:0032559) 2.412ACTC1, MYH7
ATP binding (GO:0005524) 2.432ACTC1, MYH7
purine nucleoside binding (GO:0001883) 2.222ACTC1, MYH7
ribonucleoside binding (GO:0032549) 2.222ACTC1, MYH7
purine ribonucleotide binding (GO:0032555) 2.22ACTC1, MYH7
purine nucleotide binding (GO:0017076) 2.192ACTC1, MYH7
structural molecule activity (GO:0005198) 3.12MYBPC3, TPM1
purine ribonucleoside binding (GO:0032550) 2.222ACTC1, MYH7
nucleoside phosphate binding (GO:1901265) 1.962ACTC1, MYH7
nucleoside binding (GO:0001882) 2.212ACTC1, MYH7

NET-GE enrichment

Term New enriched termICP valueGenes
actin-dependent ATPase activity (GO:0030898) NEW7.170.005ACTC1, MYH7
microfilament motor activity (GO:0000146) NEW6.650.017ACTC1, MYH7
cytoskeletal protein binding (GO:0008092) -3.020.0TPM1, TNNT2, MYH7, ACTC1, MIB1, LDB3, MYBPC3, DTNA
myosin binding (GO:0017022) -5.660.01MYBPC3, ACTC1
actin binding (GO:0003779) -3.740.0TPM1, TNNT2, MYH7, ACTC1, MIB1, LDB3, MYBPC3, DTNA
structural constituent of muscle (GO:0008307) -6.020.013MYBPC3, TPM1, MYH7
calcium ion binding (GO:0005509) NEW3.170.002TPM1, TNNT2, MYH7, ACTC1, MIB1, MYBPC3, DTNA
tropomyosin binding (GO:0005523) NEW7.10.009TPM1, TNNT2
motor activity (GO:0003774) NEW4.810.046MIB1, ACTC1, MYH7
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.269TPM1, TNNT2, LDB3, MYH7, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
single-organism process (GO:0044699) 0.489TPM1, TNNT2, LDB3, MYH7, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
biological regulation (GO:0065007) 0.398TPM1, TNNT2, MYH7, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
multicellular organismal process (GO:0032501) 1.458TPM1, TNNT2, MYH7, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
single-organism cellular process (GO:0044763) 0.658TPM1, TNNT2, LDB3, MYH7, ACTC1, PRDM16, MYBPC3, DTNA
regulation of biological process (GO:0050789) 0.458TPM1, TNNT2, MYH7, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
single-organism developmental process (GO:0044767) 1.497TPM1, TNNT2, MYH7, ACTC1, MIB1, PRDM16, MYBPC3
developmental process (GO:0032502) 1.367TPM1, TNNT2, MYH7, ACTC1, MIB1, PRDM16, MYBPC3
regulation of cellular process (GO:0050794) 0.57TPM1, TNNT2, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
muscle contraction (GO:0006936) 4.376TPM1, TNNT2, MYH7, ACTC1, MYBPC3, DTNA
actin filament-based process (GO:0030029) 3.946TPM1, TNNT2, MYH7, ACTC1, LDB3, MYBPC3
tissue morphogenesis (GO:0048729) 3.876TPM1, TNNT2, MYH7, ACTC1, MIB1, MYBPC3
striated muscle contraction (GO:0006941) 5.376TPM1, TNNT2, MYH7, ACTC1, MYBPC3, DTNA
muscle system process (GO:0003012) 4.186TPM1, TNNT2, MYH7, ACTC1, MYBPC3, DTNA
regulation of multicellular organismal process (GO:0051239) 1.876TPM1, TNNT2, MYH7, MIB1, PRDM16, MYBPC3
anatomical structure morphogenesis (GO:0009653) 2.536TPM1, TNNT2, MYH7, ACTC1, MIB1, MYBPC3
system process (GO:0003008) 2.36TPM1, TNNT2, MYH7, ACTC1, MYBPC3, DTNA
cardiac muscle tissue morphogenesis (GO:0055008) 5.85TNNT2, MYBPC3, ACTC1, TPM1, MYH7
cellular component organization (GO:0016043) 1.245TNNT2, TPM1, ACTC1, LDB3, PRDM16
movement of cell or subcellular component (GO:0006928) 2.615TNNT2, MYBPC3, ACTC1, TPM1, MYH7
muscle filament sliding (GO:0030049) 6.095TNNT2, MYBPC3, ACTC1, TPM1, MYH7
actin filament-based movement (GO:0030048) 5.545TNNT2, MYBPC3, ACTC1, TPM1, MYH7
actin-myosin filament sliding (GO:0033275) 6.095TNNT2, MYBPC3, ACTC1, TPM1, MYH7
muscle tissue morphogenesis (GO:0060415) 5.625TNNT2, MYBPC3, ACTC1, TPM1, MYH7
actin-mediated cell contraction (GO:0070252) 5.885TNNT2, MYBPC3, ACTC1, TPM1, MYH7
cardiac muscle contraction (GO:0060048) 5.885TNNT2, MYBPC3, ACTC1, TPM1, MYH7
cellular component organization or biogenesis (GO:0071840) 1.225ACTC1, TPM1, TNNT2, LDB3, PRDM16
single-multicellular organism process (GO:0044707) 1.784MIB1, ACTC1, TPM1, PRDM16
regulation of system process (GO:0044057) 3.534MYBPC3, TNNT2, TPM1, MYH7
ventricular cardiac muscle tissue morphogenesis (GO:0055010) 6.074MYBPC3, TNNT2, TPM1, MYH7
regulation of muscle contraction (GO:0006937) 4.754MYBPC3, TNNT2, TPM1, MYH7
anatomical structure development (GO:0048856) 1.584MIB1, TPM1, MYH7, PRDM16
regulation of muscle system process (GO:0090257) 4.514MYBPC3, TNNT2, TPM1, MYH7
positive regulation of biological process (GO:0048518) 1.24MIB1, ACTC1, TPM1, PRDM16
negative regulation of biological process (GO:0048519) 1.334MIB1, ACTC1, TPM1, PRDM16
regulation of localization (GO:0032879) 1.944MYBPC3, TNNT2, MIB1, TPM1
negative regulation of cellular process (GO:0048523) 1.414MIB1, ACTC1, TPM1, PRDM16
actomyosin structure organization (GO:0031032) 5.43TPM1, ACTC1, LDB3
regulation of transport (GO:0051049) 2.243MYBPC3, TNNT2, MIB1
actin cytoskeleton organization (GO:0030036) 4.13TPM1, ACTC1, LDB3
positive regulation of catalytic activity (GO:0043085) 2.43MYBPC3, TNNT2, TPM1
regulation of ATPase activity (GO:0043462) 5.593MYBPC3, TNNT2, TPM1
positive regulation of hydrolase activity (GO:0051345) 2.913MYBPC3, TNNT2, TPM1
organic substance metabolic process (GO:0071704) 0.633MIB1, MYH7, PRDM16
animal organ development (GO:0048513) 2.533MIB1, MYH7, PRDM16
positive regulation of molecular function (GO:0044093) 2.233MYBPC3, TNNT2, TPM1
regulation of molecular function (GO:0065009) 1.783MYBPC3, TNNT2, TPM1
regulation of biological quality (GO:0065008) 1.683TPM1, TNNT2, MYH7
organelle organization (GO:0006996) 2.023TPM1, ACTC1, LDB3
regulation of actin filament-based process (GO:0032970) 3.973MYBPC3, TNNT2, TPM1
regulation of heart contraction (GO:0008016) 4.353TPM1, TNNT2, MYH7
regulation of developmental process (GO:0050793) 2.13MIB1, TPM1, PRDM16
positive regulation of ATPase activity (GO:0032781) 5.993MYBPC3, TNNT2, TPM1
regulation of catalytic activity (GO:0050790) 1.973MYBPC3, TNNT2, TPM1
regulation of blood circulation (GO:1903522) 4.053TPM1, TNNT2, MYH7
metabolic process (GO:0008152) 0.583MIB1, MYH7, PRDM16
response to chemical (GO:0042221) 1.983TNNT2, TPM1, ACTC1
regulation of hydrolase activity (GO:0051336) 2.533MYBPC3, TNNT2, TPM1
primary metabolic process (GO:0044238) 0.693MIB1, MYH7, PRDM16
regulation of cellular component movement (GO:0051270) 3.083MYBPC3, TNNT2, TPM1
cytoskeleton organization (GO:0007010) 3.223TPM1, ACTC1, LDB3
response to stimulus (GO:0050896) 1.223TNNT2, TPM1, ACTC1
cellular metabolic process (GO:0044237) 0.693MIB1, MYH7, PRDM16
single-organism organelle organization (GO:1902589) 2.683TPM1, ACTC1, LDB3
positive regulation of cellular process (GO:0048522) 1.33MIB1, TPM1, PRDM16
cellular component assembly (GO:0022607) 2.142TNNT2, ACTC1
positive regulation of metabolic process (GO:0009893) 1.742ACTC1, PRDM16
regulation of cellular localization (GO:0060341) 3.032MYBPC3, TNNT2
macromolecular complex subunit organization (GO:0043933) 2.142TNNT2, PRDM16
regulation of intracellular transport (GO:0032386) 3.582MYBPC3, TNNT2
regulation of response to stimulus (GO:0048583) 1.542MYH7, PRDM16
positive regulation of macromolecule metabolic process (GO:0010604) 1.812ACTC1, PRDM16
regulation of cellular component organization (GO:0051128) 2.012MIB1, TPM1
embryo development (GO:0009790) 4.22MIB1, TPM1
cellular nitrogen compound metabolic process (GO:0034641) 1.222MYH7, PRDM16
positive regulation of gene expression (GO:0010628) 2.352ACTC1, PRDM16
nitrogen compound metabolic process (GO:0006807) 1.132MYH7, PRDM16
signal transduction (GO:0007165) 1.282MIB1, DTNA
multicellular organism development (GO:0007275) 2.542MIB1, TPM1
organic cyclic compound metabolic process (GO:1901360) 1.262MYH7, PRDM16
cellular protein metabolic process (GO:0044267) 1.632MIB1, PRDM16
in utero embryonic development (GO:0001701) 4.42MIB1, TPM1
regulation of metabolic process (GO:0019222) 1.022ACTC1, PRDM16
cellular macromolecule metabolic process (GO:0044260) 0.932MIB1, PRDM16
negative regulation of multicellular organismal process (GO:0051241) 2.842MIB1, PRDM16
regulation of heart rate (GO:0002027) 5.292TPM1, MYH7
embryo development ending in birth or egg hatching (GO:0009792) 4.352MIB1, TPM1
chordate embryonic development (GO:0043009) 4.382MIB1, TPM1
regulation of gene expression (GO:0010468) 1.372ACTC1, PRDM16
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012MIB1, ACTC1
positive regulation of cellular component organization (GO:0051130) 2.682MIB1, TPM1
negative regulation of developmental process (GO:0051093) 3.172MIB1, PRDM16
regulation of actin filament-based movement (GO:1903115) 6.332MYBPC3, TNNT2
nucleobase-containing compound metabolic process (GO:0006139) 1.352MYH7, PRDM16
regulation of macromolecule metabolic process (GO:0060255) 1.082ACTC1, PRDM16
regulation of muscle filament sliding (GO:0032971) 8.342MYBPC3, TNNT2
cellular aromatic compound metabolic process (GO:0006725) 1.32MYH7, PRDM16
cellular protein modification process (GO:0006464) 1.792MIB1, PRDM16
negative regulation of cell differentiation (GO:0045596) 3.332MIB1, PRDM16
macromolecule modification (GO:0043412) 1.732MIB1, PRDM16
protein modification process (GO:0036211) 1.792MIB1, PRDM16
sarcomere organization (GO:0045214) 6.42TPM1, LDB3
heterocycle metabolic process (GO:0046483) 1.312MYH7, PRDM16
response to oxygen-containing compound (GO:1901700) 2.572TPM1, ACTC1
heart development (GO:0007507) 4.242MIB1, MYH7
actin filament organization (GO:0007015) 4.542TNNT2, ACTC1
protein metabolic process (GO:0019538) 1.452MIB1, PRDM16
regulation of cell differentiation (GO:0045595) 2.422MIB1, PRDM16
macromolecule metabolic process (GO:0043170) 0.832MIB1, PRDM16
regulation of striated muscle contraction (GO:0006942) 5.382MYBPC3, MYH7
regulation of multicellular organismal development (GO:2000026) 2.312MIB1, PRDM16

NET-GE enrichment

Term New enriched termICP valueGenes
myosin filament assembly (GO:0031034) NEW8.630.004MYBPC3, TPM1
myosin filament organization (GO:0031033) NEW8.630.004MYBPC3, TPM1
actomyosin structure organization (GO:0031032) -5.40.0ACTC1, MYBPC3, TNNT2, TPM1, LDB3
ventricular cardiac muscle tissue morphogenesis (GO:0055010) -6.070.0MYBPC3, TNNT2, TPM1, MYH7
actin cytoskeleton organization (GO:0030036) -4.10.01ACTC1, MYBPC3, TNNT2, TPM1, LDB3
striated muscle contraction (GO:0006941) -5.370.0DTNA, MYBPC3, ACTC1, TPM1, MYH7
muscle system process (GO:0003012) -4.180.01DTNA, MYBPC3, ACTC1, TPM1, MYH7
anatomical structure morphogenesis (GO:0009653) -2.530.003TPM1, TNNT2, MYH7, ACTC1, MIB1, MYBPC3
cardiac muscle contraction (GO:0060048) -5.880.007MYBPC3, ACTC1, TPM1
regulation of ATPase activity (GO:0043462) -5.590.007MYBPC3, TNNT2, TPM1
muscle contraction (GO:0006936) -4.370.003DTNA, MYBPC3, ACTC1, TPM1, MYH7
regulation of system process (GO:0044057) -3.530.008MYBPC3, TNNT2, TPM1, MYH7
regulation of heart rate (GO:0002027) -5.290.002MYBPC3, TPM1, MYH7
actin-myosin filament sliding (GO:0033275) -6.090.0TNNT2, MYBPC3, ACTC1, TPM1, MYH7
tissue morphogenesis (GO:0048729) -3.870.0TPM1, TNNT2, MYH7, ACTC1, MIB1, MYBPC3, DTNA
multicellular organismal process (GO:0032501) -1.450.041TPM1, MYH7, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
actin filament-based process (GO:0030029) -3.940.001TPM1, TNNT2, MYH7, ACTC1, LDB3, MYBPC3
regulation of muscle contraction (GO:0006937) -4.750.008MYBPC3, TNNT2, TPM1
cardiac muscle tissue morphogenesis (GO:0055008) -5.80.0TNNT2, MYBPC3, ACTC1, TPM1, MYH7
positive regulation of ATPase activity (GO:0032781) -5.990.0MYBPC3, TNNT2, TPM1
regulation of heart contraction (GO:0008016) -4.350.032MYBPC3, TNNT2, TPM1, MYH7
muscle filament sliding (GO:0030049) -6.090.0TNNT2, MYBPC3, ACTC1, TPM1, MYH7
actin filament-based movement (GO:0030048) -5.540.0TNNT2, MYBPC3, ACTC1, TPM1, MYH7
sarcomere organization (GO:0045214) -6.40.0MYBPC3, TNNT2, TPM1, LDB3
regulation of muscle system process (GO:0090257) -4.510.016MYBPC3, TNNT2, TPM1
system process (GO:0003008) -2.30.033DTNA, MYBPC3, ACTC1, TPM1, MYH7
actin filament organization (GO:0007015) -4.540.028MYBPC3, ACTC1, TPM1, MYH7
cytoskeleton organization (GO:0007010) -3.220.002ACTC1, MYBPC3, TNNT2, TPM1, LDB3
single-multicellular organism process (GO:0044707) -1.780.035TPM1, MYH7, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
actin-mediated cell contraction (GO:0070252) -5.880.0TNNT2, MYBPC3, ACTC1, TPM1, MYH7
muscle tissue morphogenesis (GO:0060415) -5.620.0TNNT2, MYBPC3, ACTC1, TPM1, MYH7
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.289TPM1, TNNT2, LDB3, MYH7, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
cell part (GO:0044464) 0.119TPM1, TNNT2, LDB3, MYH7, ACTC1, MIB1, PRDM16, MYBPC3, DTNA
cytoplasmic part (GO:0044444) 0.828TPM1, TNNT2, LDB3, MYH7, ACTC1, MIB1, PRDM16, MYBPC3
intracellular organelle (GO:0043229) 0.517TPM1, TNNT2, LDB3, MYH7, ACTC1, MIB1, PRDM16
organelle (GO:0043226) 0.47TPM1, TNNT2, LDB3, MYH7, ACTC1, MIB1, PRDM16
organelle part (GO:0044422) 0.797TPM1, TNNT2, MYH7, ACTC1, MIB1, LDB3, MYBPC3
protein complex (GO:0043234) 1.516TPM1, TNNT2, MYH7, PRDM16, MYBPC3, DTNA
cytoplasm (GO:0005737) 1.016TPM1, MYH7, ACTC1, MIB1, LDB3, DTNA
macromolecular complex (GO:0032991) 1.356TPM1, TNNT2, MYH7, PRDM16, MYBPC3, DTNA
intracellular non-membrane-bounded organelle (GO:0043232) 1.766TPM1, TNNT2, MYH7, ACTC1, MIB1, LDB3
cytosol (GO:0005829) 1.686TPM1, TNNT2, ACTC1, MIB1, PRDM16, MYBPC3
intracellular organelle part (GO:0044446) 0.816TPM1, TNNT2, MYH7, ACTC1, MIB1, MYBPC3
non-membrane-bounded organelle (GO:0043228) 1.766TPM1, TNNT2, MYH7, ACTC1, MIB1, LDB3
cytoskeletal part (GO:0044430) 2.496TPM1, TNNT2, MYH7, ACTC1, MIB1, MYBPC3
contractile fiber part (GO:0044449) 4.536TPM1, TNNT2, MYH7, ACTC1, LDB3, MYBPC3
sarcomere (GO:0030017) 5.955TNNT2, MYBPC3, ACTC1, TPM1, MYH7
cytoskeleton (GO:0005856) 2.554MIB1, ACTC1, TPM1, LDB3
cell projection (GO:0042995) 2.474TPM1, ACTC1, DTNA, LDB3
membrane (GO:0016020) 0.684MIB1, ACTC1, TPM1, DTNA
myofibril (GO:0030016) 6.143TPM1, TNNT2, MYH7
contractile fiber (GO:0043292) 5.813TPM1, TNNT2, MYH7
membrane-bounded organelle (GO:0043227) 0.473MIB1, ACTC1, PRDM16
actin filament bundle (GO:0032432) 5.742TPM1, MYH7
myofilament (GO:0036379) 7.162MYBPC3, TNNT2
myosin filament (GO:0032982) 6.712MYBPC3, MYH7
vesicle (GO:0031982) 1.642MIB1, ACTC1
stress fiber (GO:0001725) 5.812TPM1, MYH7
integral component of membrane (GO:0016021) 1.142TPM1, DTNA
plasma membrane (GO:0005886) 1.392MIB1, DTNA
muscle myosin complex (GO:0005859) 6.862MYBPC3, MYH7
neuron part (GO:0097458) 2.642MIB1, DTNA
intrinsic component of membrane (GO:0031224) 1.132TPM1, DTNA
myosin complex (GO:0016459) 5.552MYBPC3, MYH7
Z disc (GO:0030018) 5.112MYH7, LDB3
myosin II complex (GO:0016460) 6.542MYBPC3, MYH7
membrane part (GO:0044425) 0.952TPM1, DTNA
contractile actin filament bundle (GO:0097517) 5.812TPM1, MYH7
plasma membrane part (GO:0044459) 1.952TPM1, DTNA
cell junction (GO:0030054) 2.752ACTC1, DTNA
actomyosin (GO:0042641) 5.662TPM1, MYH7

NET-GE enrichment

Term New enriched termICP valueGenes
actin filament bundle (GO:0032432) -5.740.019TPM1, ACTC1, MYH7
cytoskeletal part (GO:0044430) -2.490.001TPM1, TNNT2, MYH7, ACTC1, MIB1, MYBPC3
cell-substrate adherens junction (GO:0005924) NEW3.830.0TPM1, MYH7, ACTC1, MIB1, LDB3, DTNA
focal adhesion (GO:0005925) NEW3.830.0TPM1, MYH7, ACTC1, MIB1, LDB3, DTNA
Z disc (GO:0030018) -5.110.0DTNA, MYBPC3, ACTC1, LDB3, MYH7
cell-substrate junction (GO:0030055) NEW3.820.0TPM1, MYH7, ACTC1, MIB1, LDB3, DTNA
stress fiber (GO:0001725) -5.810.017TPM1, ACTC1, MYH7
myosin filament (GO:0032982) -6.710.003MYBPC3, MYH7
I band (GO:0031674) NEW6.670.04TPM1, ACTC1
muscle myosin complex (GO:0005859) -6.860.002MYBPC3, MYH7
myosin complex (GO:0016459) -5.550.036MYBPC3, MYH7
cell junction (GO:0030054) -2.750.012TPM1, MYH7, ACTC1, MIB1, LDB3, MYBPC3, DTNA
actomyosin (GO:0042641) -5.660.005TPM1, ACTC1, MYH7
protein complex (GO:0043234) -1.510.036TPM1, TNNT2, MYH7, ACTC1, PRDM16, MYBPC3, DTNA
anchoring junction (GO:0070161) NEW3.610.001TPM1, MYH7, ACTC1, MIB1, LDB3, DTNA
adherens junction (GO:0005912) NEW3.660.001TPM1, MYH7, ACTC1, MIB1, LDB3, DTNA
myofilament (GO:0036379) -7.160.001MYBPC3, TNNT2
sarcomere (GO:0030017) -5.950.0TNNT2, MYBPC3, ACTC1, TPM1, MYH7
myosin II complex (GO:0016460) -6.540.014MYBPC3, MYH7
contractile fiber part (GO:0044449) -4.530.0TPM1, TNNT2, MYH7, ACTC1, LDB3, MYBPC3, DTNA