Disease table of CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC OMIM ID: PS192600

Gene-disease associations table

Gene	Associated with CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
ACTC1	ClinVar, OMIM, HUMSAVAR	HGNC link	15q14	4	PS108800, PS192600, PS115200, PS604169
PRKAG2	ClinVar, OMIM, HUMSAVAR	HGNC link	7q36.1	3	PS192600, 194200, 261740
JPH2	ClinVar, OMIM, HUMSAVAR	HGNC link	20q13.12	2	PS192600, 603829
MYL2	ClinVar, OMIM, HUMSAVAR	HGNC link	12q24.11	1	PS192600
MYL3	ClinVar, OMIM, HUMSAVAR	HGNC link	3p21.31	1	PS192600
TNNI3	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.42	3	PS192600, PS115200, PS115210
CAV3	ClinVar, OMIM, HUMSAVAR	HGNC link	3p25.3	7	PS192600, 272120, PS192500, 123320, 614321, PS159000, 606072
TNNT2	ClinVar, OMIM, HUMSAVAR	HGNC link	1q32.1	5	PS192600, PS604169, 218040, PS115200, PS115210
MYH6	ClinVar, OMIM, HUMSAVAR	HGNC link	14q11.2	6	PS192600, 234750, PS108800, PS115200, 140500, PS608567
MYH7	ClinVar, OMIM, HUMSAVAR	HGNC link	14q11.2	9	PS192600, 160500, PS604169, PS115200, 603829, 255310, 255160, 608358, 181430
TPM1	ClinVar, OMIM, HUMSAVAR	HGNC link	15q22.2	4	PS604169, PS604772, PS115200, PS192600
MYPN	ClinVar, OMIM, HUMSAVAR	HGNC link	10q21.3	3	PS192600, PS115200, PS115210
NEXN	ClinVar, OMIM, HUMSAVAR	HGNC link	1p31.1	2	PS192600, PS115200
TTN	ClinVar, OMIM, HUMSAVAR	HGNC link	2q31.2	8	PS192600, PS253600, 600334, PS115200, 603689, 603829, 611705, PS160150
VCL	ClinVar, OMIM, HUMSAVAR	HGNC link	10q22.2	3	PS192600, PS115200, 603829
MYLK2	ClinVar, OMIM, HUMSAVAR	HGNC link	20q11.21	1	PS192600
LDB3	ClinVar, OMIM, HUMSAVAR	HGNC link	10q23.2	4	PS604169, PS192600, PS601419, PS115200
TCAP	ClinVar, OMIM, HUMSAVAR	HGNC link	17q12	2	PS192600, PS253600
ACTN2	ClinVar, OMIM, HUMSAVAR	HGNC link	1q43	2	PS192600, PS115200
MYBPC3	ClinVar, OMIM, HUMSAVAR	HGNC link	11p11.2	4	PS604169, PS604772, PS115200, PS192600
MYOZ2	ClinVar, OMIM, HUMSAVAR	HGNC link	4q26	1	PS192600
PLN	ClinVar, OMIM	HGNC link	6q22.31	2	PS192600, PS115200
CSRP3	ClinVar, OMIM, HUMSAVAR	HGNC link	11p15.1	2	PS192600, PS115200
CALR3	ClinVar, OMIM, HUMSAVAR	HGNC link	19p13.11	1	PS192600
TNNC1	ClinVar, OMIM, HUMSAVAR	HGNC link	3p21.1	2	PS192600, PS115200

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Common tandem group	Number of genes in this tandem group associated to this disease	Genes in this tandem group associated to this disease
Group 626	2	MYH6, MYH7

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
14q11.2	2	MYH6, MYH7

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
14q11	2	MYH6, MYH7
3p21	2	MYL3, TNNC1

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
3p2	3	MYL3, CAV3, TNNC1
11p1	2	CSRP3, MYBPC3
14q1	2	MYH6, MYH7
20q1	2	JPH2, MYLK2
10q2	3	MYPN, LDB3, VCL

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
15q	2	ACTC1, TPM1
20q	2	JPH2, MYLK2
14q	2	MYH6, MYH7
3p	3	MYL3, CAV3, TNNC1
11p	2	CSRP3, MYBPC3
10q	3	MYPN, LDB3, VCL
1q	2	TNNT2, ACTN2

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	2	CSRP3, MYBPC3
10	3	MYPN, LDB3, VCL
20	2	JPH2, MYLK2
14	2	MYH6, MYH7
19	2	CALR3, TNNI3
1	3	NEXN, TNNT2, ACTN2
3	3	MYL3, CAV3, TNNC1
15	2	ACTC1, TPM1

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs
ACTC1	YES	1	YY1
MYL2	YES	1	ANKRD1
TNNI3	YES	2	SP1, MEF2A
CAV3	YES	1	RORA
MYH6	YES	3	JARID2, TBX5, ELK3

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ACTC1	MYL3	No	1	SP1
ACTC1	TNNI3	No	2	TNNI3K, HSPB2
ACTC1	TNNT2	No	1	TPM1
ACTC1	MYH6	No	3	MCM2, TPM1, HSPB2
ACTC1	TPM1	Yes	4	SP1, TPM1, PAN2, ACTA2
ACTC1	MYPN	No	1	MCM2
ACTC1	NEXN	No	1	PAN2
ACTC1	TTN	No	3	SP1, MCM2, HSPB2
ACTC1	VCL	No	1	ITGA4
ACTC1	MYLK2	No	1	ESR1
ACTC1	TCAP	No	1	HSPB2
ACTC1	ACTN2	No	2	CAPN1, TPM1
ACTC1	MYBPC3	No	3	CAPN1, TNNI3K, HSPB2
ACTC1	MYOZ2	No	1	HSPB2
PRKAG2	TPM1	No	1	ELAVL1
PRKAG2	VCL	No	2	ASNS, PFAS
JPH2	CAV3	Yes	0
MYL2	TNNI3	No	1	TRIM63
MYL2	TTN	No	1	TRIM63
MYL2	TCAP	No	1	TRIM63
MYL2	MYBPC3	No	1	TRIM63
MYL2	TNNC1	No	1	TRIM63
MYL3	MYH7	No	1	YWHAQ
MYL3	TPM1	No	2	SP1, YWHAQ
MYL3	TTN	No	2	SP1, YWHAQ
MYL3	VCL	No	1	YWHAQ
MYL3	MYLK2	No	1	YWHAQ
MYL3	ACTN2	No	1	YWHAQ
TNNI3	TNNT2	Yes	1	TNNC1
TNNI3	MYH6	No	1	HSPB2
TNNI3	TPM1	No	1	TNNT2
TNNI3	TTN	No	3	TRIM55, HSPB2, TRIM63
TNNI3	TCAP	No	3	TRIM55, HSPB2, TRIM63
TNNI3	MYBPC3	No	4	TRIM55, HSPB2, TRIM63, TNNI3K
TNNI3	MYOZ2	No	1	HSPB2
TNNI3	TNNC1	Yes	2	TNNT2, TRIM63
CAV3	TPM1	No	1	EGFR
CAV3	TTN	No	1	ADRB2
CAV3	VCL	No	1	DAG1
CAV3	MYLK2	No	1	ADRB2
TNNT2	MYH6	No	2	TPM1, TNNI1
TNNT2	MYH7	No	1	TNNI1
TNNT2	TPM1	Yes	2	TPM1, TNNI1
TNNT2	ACTN2	No	2	TPM1, TNNI1
TNNT2	TNNC1	Yes	2	TNNI3, TNNI1
MYH6	MYH7	No	3	ACTN2, TNNI1, TPM2
MYH6	TPM1	Yes	4	ACTN2, TPM1, TNNI1, TPM2
MYH6	MYPN	No	2	ACTN2, MCM2
MYH6	TTN	No	2	MCM2, HSPB2
MYH6	LDB3	No	1	ACTN2
MYH6	TCAP	No	1	HSPB2
MYH6	ACTN2	Yes	4	ACTN2, TPM1, TNNI1, TPM2
MYH6	MYBPC3	No	1	HSPB2
MYH6	MYOZ2	No	2	ACTN2, HSPB2
MYH6	CALR3	No	1	TMEM132A
MYH6	TNNC1	No	1	TNNI1
MYH7	TPM1	No	6	ACTN2, TNNI1, KXD1, RBPJ, YWHAQ, TPM2
MYH7	MYPN	No	2	ACTN2, ACTN3
MYH7	TTN	No	1	YWHAQ
MYH7	VCL	No	2	YWHAQ, SPTAN1
MYH7	MYLK2	No	2	TMEM260, YWHAQ
MYH7	LDB3	No	1	ACTN2
MYH7	ACTN2	Yes	6	ACTN2, DISC1, TNNI1, ACTN3, YWHAQ, TPM2
MYH7	MYOZ2	No	1	ACTN2
MYH7	TNNC1	No	1	TNNI1
TPM1	MYPN	No	3	ACTN2, NEB, CAPZA2
TPM1	NEXN	No	18	MYO1C, CORO1C, CALML3, ACTB, ANLN, IQGAP1, MYH9, PPP1CB, MYO19, CAPZA2, SYNPO, TMOD3, MYO18A, MYH10, LIMA1, FLNA, PAN2, DBN1
TPM1	TTN	No	4	SP1, YWHAQ, ACTN1, CDK2
TPM1	VCL	No	3	YWHAQ, CDK2, ABI2
TPM1	MYLK2	No	1	YWHAQ
TPM1	LDB3	No	2	ACTN2, ATP5F1
TPM1	ACTN2	Yes	14	ACTN2, TPM1, MYH2, ACTN1, YWHAQ, MYH4, TNNI1, MYH6, MYH1, TPM3, TPM4, ACTN4, MYH8, TPM2
TPM1	MYOZ2	No	3	ACTN2, ACTN4, ACTN1
TPM1	TNNC1	No	5	TNNI1, TNNT3, TNNT2, CNN1, TNNT1
MYPN	NEXN	No	1	CAPZA2
MYPN	TTN	Yes	4	ANKRD1, MCM2, DLG4, ANKRD23
MYPN	VCL	No	1	XPO1
MYPN	LDB3	No	1	ACTN2
MYPN	TCAP	No	1	TTN
MYPN	ACTN2	Yes	2	ACTN2, ACTN3
MYPN	MYBPC3	No	1	TTN
MYPN	MYOZ2	No	1	ACTN2
NEXN	TTN	No	1	CALM1
NEXN	VCL	No	3	MYO1C, LIMA1, TRIM15
NEXN	ACTN2	No	1	HSPB1
NEXN	MYBPC3	No	1	CUL1
TTN	VCL	No	4	NTRK1, EWSR1, YWHAQ, CDK2
TTN	MYLK2	No	2	ADRB2, YWHAQ
TTN	LDB3	No	1	ALB
TTN	TCAP	Yes	4	ANKRD2, TRIM55, HSPB2, TRIM63
TTN	ACTN2	No	3	YWHAQ, MYPN, ACTN1
TTN	MYBPC3	Yes	3	TRIM55, HSPB2, TRIM63
TTN	MYOZ2	No	4	EWSR1, HSPB2, ACTN1, TCAP
TTN	TNNC1	No	1	TRIM63
VCL	MYLK2	No	1	YWHAQ
VCL	ACTN2	No	1	YWHAQ
VCL	MYOZ2	No	1	EWSR1
VCL	TNNC1	No	1	HSPB2
MYLK2	ACTN2	No	1	YWHAQ
LDB3	ACTN2	Yes	1	ACTN2
LDB3	MYOZ2	No	1	ACTN2
TCAP	ACTN2	No	2	MYOZ2, MYOZ1
TCAP	MYBPC3	No	4	TTN, TRIM55, HSPB2, TRIM63
TCAP	MYOZ2	Yes	2	CRK, HSPB2
TCAP	TNNC1	No	1	TRIM63
ACTN2	MYBPC3	No	1	CAPN1
ACTN2	MYOZ2	Yes	3	ACTN2, ACTN4, ACTN1
ACTN2	TNNC1	No	1	TNNI1
MYBPC3	MYOZ2	No	1	HSPB2
MYBPC3	TNNC1	No	1	TRIM63

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
ACTC1	MYL2	Yes	binding	18	TPM1, MYH6, MYH7, TNNC1, MYH8, MYH1, MYH3, TNNI3, MYH9, MYL4, TNNC2, TPM3, MYH14, MYH10, MYH7B, TPM4, TPM2, MYL3
ACTC1	MYL3	Yes	binding	21	TPM2, TPM1, MYH11, MYH6, MYH2, TNNC1, MYH9, MYL4, TPM3, MYH1, MYH3, TNNI3, UBC, MYH14, TNNC2, MYH8, MYH7, MYH10, MYH4, TPM4, MYL2
ACTC1	TNNI3	Yes	binding	18	MYL3, TPM1, MYH11, MYH6, MYH7, MYL2, MYH8, MYH14, MYH3, TNNC1, MYH1, TNNC2, TPM3, MYO5B, TPM4, MYL4, TPM2, MYO5C
ACTC1	TNNT2	No	-	15	TPM1, MYH6, MYH7, TNNC1, MYH8, TPM3, TNNI3, MYH14, TNNC2, MYH3, MYL2, TPM4, MYL4, TPM2, MYL3
ACTC1	MYH6	Yes	binding	21	TPM4, TPM1, MYH11, MYH7, MYH2, TNNC1, MYL4, TPM2, TPM3, MYH14, MYH3, TNNI3, MYH9, TNNC2, MYH8, MYH1, UBC, MYH10, MYH4, MYL2, MYL3
ACTC1	MYH7	Yes	binding	18	TPM1, MYH11, MYL3, MYL2, TPM2, MYH4, MYH2, MYH14, MYH3, TNNI3, TNNC1, MYH1, TNNC2, TPM3, MYH6, MYH10, MYH8, MYH9
ACTC1	TPM1	Yes	binding	20	TPM2, CFL1, MYH11, MYH6, MYH7, TNNC1, MYL4, TPM3, MYH1, MYH3, TNNI3, MYH14, MYL2, UBC, DSTN, TPM4, ACTN4, MYH8, TNNC2, MYL3
ACTC1	TTN	No	-	16	TPM1, MYL3, MYL2, TNNC1, MYH8, MYH3, TNNI3, MYH14, MYL4, TNNC2, TPM3, MYH6, UBC, TPM4, WDR1, TPM2
ACTC1	VCL	No	-	14	TPM1, MYH11, PFN1, WDR1, CORO2B, SRF, PFN2, TPM3, PFN4, UBC, TPM4, ACTN4, WASL, TPM2
ACTC1	MYLK2	No	-	2	MYH14, MYL2
ACTC1	LDB3	No	-	1	ACTN4
ACTC1	ACTN2	No	-	16	TPM1, MYH6, MYH7, TNNC1, MYH8, MYH3, TNNI3, TNNC2, TPM3, UBC, MYL2, TPM4, ACTN4, MYL4, TPM2, MYL3
ACTC1	MYBPC3	No	-	21	TPM4, TPM1, MYH11, MYH6, MYH2, TNNC1, MYL4, TPM2, TPM3, MYH14, MYH3, TNNI3, MYH9, TNNC2, MYH8, MYH1, MYH7, MYH10, MYH4, MYL2, MYL3
ACTC1	MYOZ2	No	-	1	ACTN4
ACTC1	PLN	No	-	0
ACTC1	TNNC1	Yes	activation	17	TPM1, MYO5B, MYL3, MYH7, MYH8, TPM3, TNNI3, MYH14, TNNC2, MYH3, MYH6, UBC, MYL2, TPM4, MYL4, TPM2, MYO5C
PRKAG2	TNNI3	No	-	2	PRKACA, PRKACB
PRKAG2	MYLK2	No	-	2	PRKACA, PRKACB
PRKAG2	PLN	No	-	2	PRKACA, PRKACB
MYL2	MYL3	Yes	binding	32	TPM1, TMOD1, TNNI1, MYL4, MYH9, VIM, TPM3, MYH1, MYBPC1, TPM2, MYL1, TNNT2, MYH7, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, ACTC1, TNNI3, MYBPC3, MYH10, ACTN2, TNNC1, DES, TNNT3, MYH3, TTN, TNNI2, TPM4
MYL2	TNNI3	Yes	binding	30	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, TPM3, MYH1, MYBPC1, TPM2, MYL1, TNNT2, MYH7, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, ACTC1, MYBPC3, MYL3, ACTN2, TNNC1, DES, MYH3, TTN, TNNI2, TPM4
MYL2	TNNT2	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, ACTN2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
MYL2	MYH6	Yes	binding	33	TPM1, TMOD1, TNNI1, MYH8, MYH9, VIM, TPM3, MYH1, MYBPC1, TPM2, MYL1, TNNT2, MYH7, MYBPC2, MYH14, NEB, TNNC2, MYL4, TNNT1, ACTC1, TNNI3, CGN, MYBPC3, MYH10, MYL3, ACTN2, TNNC1, DES, TNNT3, MYH3, TTN, TNNI2, TPM4
MYL2	MYH7	Yes	binding	23	TPM1, MYH8, MYH9, TPM3, TPM2, MYL1, TNNT2, MYL3, MYH1, MYH14, MYH3, TNNC2, ACTC1, TNNI3, CGN, MYBPC3, ACTN2, TNNC1, TNNI1, TNNT3, MYH6, TNNI2, MYH10
MYL2	TPM1	Yes	binding	30	TMOD1, TNNI1, MYH8, TNNT3, VIM, TPM3, MYH1, MYBPC1, TPM2, MYL1, TNNT2, MYH7, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYL4, TNNT1, ACTC1, TNNI3, MYBPC3, MYL3, ACTN2, TNNC1, DES, MYH3, TTN, TNNI2, TPM4
MYL2	MYPN	No	-	3	ACTN2, TTN, NEB
MYL2	TTN	Yes	binding	27	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYBPC3, ACTN2, TNNC1, TNNI1, TPM3, TNNI2, TPM4
MYL2	VCL	No	-	6	ACTN2, TPM1, TTN, TPM3, TPM4, TPM2
MYL2	MYLK2	Yes	activation, binding	1	MYH14
MYL2	LDB3	No	-	1	ACTN2
MYL2	ACTN2	Yes	binding	27	TPM1, TMOD1, DES, MYH8, TNNT3, VIM, TPM3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, NEB, TNNC2, MYL4, TNNT1, TNNI3, MYH7, MYBPC3, MYL3, TNNC1, TNNI1, MYH3, TTN, TNNI2, TPM4
MYL2	MYBPC3	Yes	binding	31	TPM1, TMOD1, TNNI1, MYL4, MYH9, VIM, MYL3, MYH1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, NEB, MYH14, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC1, TPM4, ACTN2, TTN, DES, TNNT3, TPM3, TNNC1, TNNI2, MYH10
MYL2	MYOZ2	No	-	1	ACTN2
MYL2	PLN	No	-	3	PPP1CC, PPP1CA, PPP1CB
MYL2	TNNC1	Yes	binding	29	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, ACTC1, TNNI3, MYH7, MYBPC3, ACTN2, TTN, DES, TPM3, TNNI2, TPM4
MYL3	TNNI3	Yes	binding	32	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYH3, MYH1, MYBPC1, TPM2, MYLPF, MYL1, MYH11, MYH7, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, ACTC1, TNNT2, MYBPC3, ACTN2, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
MYL3	TNNT2	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, TPM3, MYBPC1, TPM2, MYL1, MYH6, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TNNC1, TNNI1, MYH3, TTN, TNNI2, TPM4
MYL3	MYH6	Yes	binding	42	TPM1, TMOD1, DES, MYL4, MYOM1, TNNT3, VIM, TPM3, MYH1, MYL6B, MYBPC1, TNNC2, MYLPF, MYL1, MYH11, MYH7, MYBPC2, TNNI1, MYH14, NEB, MYL2, TNNT1, MYH8, TPM2, MYL5, MYH2, MYH4, ACTC1, TNNI3, MYL9, TNNT2, MYBPC3, TPM4, ACTN2, TTN, MYH13, MYH9, MYH3, TNNC1, TNNI2, UBC, MYH10
MYL3	MYH7	Yes	binding	31	TPM1, TNNI1, MYH8, MYOM1, MYH9, TPM3, MYL6B, TPM2, MYLPF, MYL1, MYH11, MYH6, MYH1, MYH14, TNNC2, MYL5, MYH2, MYH4, ACTC1, TNNI3, MYL9, TNNT2, MYBPC3, ACTN2, MYL2, TNNC1, MYH13, TNNT3, MYH3, TNNI2, MYH10
MYL3	TPM1	Yes	binding	34	TMOD1, TNNI1, MYL4, TNNT3, VIM, TPM3, MYH1, MYL6B, MYBPC1, TPM2, MYL1, MYH11, MYH7, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, ACTC1, TNNI3, MYL9, TNNT2, MYBPC3, ACTN2, MYL2, TNNC1, DES, MYH3, TTN, TNNI2, UBC, TPM4
MYL3	MYPN	No	-	3	ACTN2, TTN, NEB
MYL3	TTN	Yes	binding	28	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, TPM3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC3, ACTN2, MYL2, TNNC1, DES, MYH3, TNNI2, UBC, TPM4
MYL3	VCL	No	-	10	ACTN2, TPM1, MYH11, TTN, TPM3, MYL9, UBC, TPM4, MYL6B, TPM2
MYL3	MYLK2	No	-	6	MYLPF, MYL5, MYH14, MYL9, MYL6B, MYL2
MYL3	LDB3	No	-	1	ACTN2
MYL3	ACTN2	Yes	binding	28	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, TPM3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, MYL2, TTN, DES, MYH3, TNNC1, TNNI2, UBC, TPM4
MYL3	MYBPC3	Yes	binding	40	TPM1, TMOD1, MYH13, MYL4, MYOM1, TNNT3, VIM, MYH6, MYH1, MYL6B, TNNC2, MYLPF, MYL1, MYH11, MYH7, MYBPC2, TNNI1, MYH2, MYH14, NEB, MYL2, MYH8, TPM2, MYL5, TPM3, TNNT1, MYH4, TNNI3, MYL9, TNNT2, MYBPC1, TPM4, ACTN2, TTN, DES, MYH9, MYH3, TNNC1, TNNI2, MYH10
MYL3	MYOZ2	No	-	1	ACTN2
MYL3	TNNC1	Yes	binding	30	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYH3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, ACTC1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, DES, TPM3, TNNI2, UBC, TPM4
TNNI3	TNNT2	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, MYH7, MYBPC3, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
TNNI3	MYH6	Yes	binding	33	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYH3, MYH1, MYBPC1, TPM2, MYLPF, MYL1, MYH11, MYH7, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, ACTC1, TNNT2, MYBPC3, MYL3, ACTN2, PROC, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
TNNI3	MYH7	Yes	binding	22	TPM1, MYH8, TNNT3, MYH3, TPM2, MYLPF, MYL1, MYH11, MYL3, MYH1, MYH14, TNNC2, TPM3, ACTC1, TNNT2, MYBPC3, ACTN2, MYL2, TNNC1, TNNI1, MYH6, TNNI2
TNNI3	TPM1	Yes	binding	31	TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYH1, MYBPC1, TPM2, MYL1, MYH11, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, ACTC1, MYH7, TNNT2, MYBPC3, ACTN2, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
TNNI3	MYPN	No	-	3	ACTN2, TTN, NEB
TNNI3	TTN	Yes	binding	27	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, MYBPC3, ACTN2, MYL2, TNNC1, TNNI1, TPM3, TNNI2, TPM4
TNNI3	VCL	No	-	7	ACTN2, TPM1, MYH11, TTN, TPM3, TPM4, TPM2
TNNI3	MYLK2	No	-	8	MYLPF, PRKX, PAK3, PRKACG, MYH14, MYL2, PRKACA, PRKACB
TNNI3	LDB3	No	-	1	ACTN2
TNNI3	ACTN2	Yes	binding	27	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, TPM3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, NEB, TNNC2, MYH8, TNNT1, MYH7, MYBPC3, MYL3, MYL2, TNNC1, TNNI1, MYH3, TTN, TNNI2, TPM4
TNNI3	MYBPC3	Yes	binding	31	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYH1, TPM2, MYLPF, MYL1, MYH11, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, MYH7, TNNT2, MYBPC1, ACTN2, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
TNNI3	MYOZ2	No	-	1	ACTN2
TNNI3	PLN	No	-	4	PRKACA, PRKACB, PRKACG, PRKX
TNNI3	TNNC1	Yes	binding	31	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, ACTC1, MYH7, MYO5B, MYBPC3, ACTN2, MYL2, TTN, MYO5C, DES, TPM3, TNNI2, TPM4
TNNT2	MYH6	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
TNNT2	MYH7	Yes	binding	18	ACTN2, MYL1, MYH6, MYL2, TNNC1, MYH8, TNNI1, MYH14, MYH3, TNNI3, TNNT3, TNNC2, TPM3, TPM1, MYBPC3, TNNI2, TPM2, MYL3
TNNT2	TPM1	Yes	binding	28	TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
TNNT2	MYPN	No	-	3	ACTN2, TTN, NEB
TNNT2	TTN	Yes	binding	28	TPM1, TMOD1, CD2AP, MYL4, TNNT3, VIM, TPM3, DES, TPM2, MYBPC1, MYL1, MYH6, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC3, MYL3, ACTN2, MYL2, TNNC1, TNNI1, MYH3, TNNI2, TPM4
TNNT2	VCL	No	-	6	ACTN2, TPM1, TTN, TPM3, TPM4, TPM2
TNNT2	MYLK2	No	-	2	MYH14, MYL2
TNNT2	LDB3	No	-	1	ACTN2
TNNT2	ACTN2	Yes	binding	27	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
TNNT2	MYBPC3	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC1, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4
TNNT2	MYOZ2	No	-	1	ACTN2
TNNT2	TNNC1	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, TNNI1, TPM3, TNNI2, TPM4
MYH6	MYH7	Yes	binding	54	TPM1, HSP90AB1, RAB11A, TNNI1, MYH8, MYOM1, TNNT3, MYL3, MYL7, MYL12A, MYL6B, MYBPC3, MYL2, MYLPF, MYL1, MYH11, MYH2, KIF3C, ACTA1, MYH1, FCHO1, MYH14, TNNC2, ACTG2, EXOC6, TPM2, KIF3B, MYL5, RABL2A, TPM3, ACTA2, MYH4, ACTC1, RAB11B, HSP90AA1, TNNI3, MYL9, CGN, TNNT2, MYL12B, GAS7, FCHO2, KIF5B, ACTN2, ACTBL2, EXOC6B, RAB25, MYH13, MYH9, MYH3, TNNC1, TNNI2, MYH10, KIF5A
MYH6	TPM1	Yes	binding	38	TMOD1, TNNI1, MYH8, TNNT3, VIM, MYL3, MYH1, MYL6B, MYBPC3, TNNC2, MYBPC1, TNNT1, MYL1, MYH11, MYH7, MYBPC2, ACTA1, MYH14, NEB, MYH3, MYL2, ACTG2, MYL4, TPM2, ACTA2, ACTC1, TNNI3, MYL9, TNNT2, MYL12B, ACTN2, TTN, DES, TPM3, TNNC1, TNNI2, UBC, TPM4
MYH6	MYPN	No	-	3	ACTN2, TTN, NEB
MYH6	TTN	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, TNNI3, MYBPC3, ACTN2, MYL2, TNNC1, TNNI1, TPM3, TNNI2, UBC, TPM4
MYH6	VCL	No	-	15	ACTN2, TPM1, MYH11, ACTA2, TTN, ACTA1, TPM3, MYL9, HSP90AA1, ACTG2, UBC, MYL12B, MYL6B, TPM4, TPM2
MYH6	MYLK2	No	-	9	MYLPF, MYL5, MYL9, MYL12A, MYH14, MYL7, MYL12B, MYL6B, MYL2
MYH6	LDB3	No	-	1	ACTN2
MYH6	ACTN2	Yes	binding	30	TPM1, TMOD1, TNNI1, MYH8, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, ACTA2, MYBPC2, ACTA1, NEB, MYH3, TNNC2, MYL4, TNNT1, TNNI3, MYH7, MYBPC3, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, UBC, TPM4
MYH6	MYBPC3	Yes	binding	40	TPM1, TMOD1, MYH13, MYL4, MYOM1, TNNT3, VIM, MYL3, MYH1, MYL6B, TNNC2, MYLPF, MYL1, MYH11, MYH7, MYBPC2, TNNI1, MYH2, MYH14, NEB, MYL2, MYH8, TPM2, MYL5, TPM3, TNNT1, MYH4, TNNI3, MYL9, TNNT2, MYBPC1, MYH10, ACTN2, TNNC1, DES, MYH9, MYH3, TTN, TNNI2, TPM4
MYH6	MYOZ2	No	-	1	ACTN2
MYH6	CSRP3	No	-	1	MYOD1
MYH6	TNNC1	Yes	binding	30	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNT1, ACTC1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, DES, TPM3, TNNI2, UBC, TPM4
MYH7	TPM1	Yes	binding	27	MYH8, TNNT3, TPM3, MYL6B, MYBPC3, TPM2, MYL1, MYH11, MYL3, ACTA1, MYH1, MYH14, TNNC2, ACTG2, MYH6, ACTA2, ACTC1, TNNI3, MYL9, TNNT2, MYL12B, ACTN2, MYL2, TNNC1, TNNI1, MYH3, TNNI2
MYH7	MYPN	No	-	1	ACTN2
MYH7	TTN	No	-	19	ACTN2, TNNI3, TPM1, TNNT2, MYL3, MYL2, TNNC1, MYH8, MYL1, TNNI1, MYH14, MYH3, TNNI2, TNNT3, TNNC2, TPM3, MYH6, MYBPC3, TPM2
MYH7	VCL	No	-	12	ACTN2, TPM1, MYH11, ACTA2, ACTA1, TPM3, MYL9, HSP90AA1, ACTG2, MYL12B, MYL6B, TPM2
MYH7	MYLK2	No	-	9	MYLPF, MYL5, MYL9, MYL12A, MYH14, MYL7, MYL12B, MYL6B, MYL2
MYH7	LDB3	No	-	1	ACTN2
MYH7	ACTN2	Yes	binding	19	TNNI3, TPM1, TNNT2, TPM3, ACTA2, TNNC1, TNNI1, MYH8, ACTA1, MYL1, MYH3, TNNI2, TNNT3, TNNC2, MYH6, MYL2, MYBPC3, TPM2, MYL3
MYH7	MYBPC3	Yes	binding	30	TPM1, TNNI1, MYH8, MYOM1, MYH9, TPM3, MYL6B, TPM2, MYLPF, MYL1, MYH11, MYH6, MYH1, MYH14, TNNC2, MYL5, MYH2, MYH4, TNNI3, MYL9, TNNT2, MYL3, ACTN2, MYL2, TNNC1, MYH13, TNNT3, MYH3, TNNI2, MYH10
MYH7	MYOZ2	No	-	1	ACTN2
MYH7	TNNC1	Yes	binding	19	ACTN2, TNNI3, TPM1, TNNT2, MYL3, MYL2, TNNI1, MYH8, MYL1, ACTC1, MYH14, MYH3, TNNI2, TNNT3, TNNC2, TPM3, MYH6, MYBPC3, TPM2
TPM1	MYPN	No	-	3	ACTN2, TTN, NEB
TPM1	TTN	Yes	binding	31	TMOD1, TNNI1, MYL4, VCL, ACTN1, TNNT3, VIM, MYL3, TLN1, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYBPC3, ACTN2, MYL2, TNNC1, DES, TPM3, TNNI2, UBC, TPM4
TPM1	VCL	Yes	binding	24	CALD1, ACTN4, TLN1, MYH11, ACTN1, MYL6B, ACTA1, TPM2, ITGB5, SORBS3, ACTG2, ACTA2, MYL9, PXN, MYL12B, ACTN2, MYL6, TTN, SORBS1, TPM3, ITGA1, LMOD1, UBC, TPM4
TPM1	MYLK2	No	-	6	MYL6, MYH14, MYL9, MYL12B, MYL6B, MYL2
TPM1	LDB3	No	-	3	ACTN2, ACTN4, ACTN1
TPM1	ACTN2	Yes	binding	38	TMOD1, TNNI1, MYH8, VCL, ACTN1, PXN, TNNT3, VIM, MYL3, TLN1, ACTN4, MYBPC1, TPM2, MYL1, TNNT2, ACTA2, MYBPC2, ACTA1, NEB, MYH3, TNNC2, ITGB5, MYH6, MYL4, TNNT1, SPTBN1, TNNI3, MYH7, MYBPC3, MYL2, TTN, DES, TPM3, ITGA1, TNNC1, TNNI2, UBC, TPM4
TPM1	MYBPC3	Yes	binding	32	TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYH1, MYL6B, TPM2, MYL1, MYH11, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYL9, MYH7, TNNT2, MYBPC1, ACTN2, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
TPM1	MYOZ2	No	-	3	ACTN2, ACTN4, ACTN1
TPM1	TNNC1	Yes	binding	30	TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, ACTC1, TNNI3, MYH7, MYBPC3, ACTN2, MYL2, TTN, DES, TPM3, TNNI2, UBC, TPM4
MYPN	TTN	Yes	binding	4	ACTN2, ANKRD1, NEB, ANKRD23
MYPN	VCL	No	-	2	ACTN2, TTN
MYPN	LDB3	No	-	1	ACTN2
MYPN	ACTN2	Yes	binding	2	TTN, NEB
MYPN	MYBPC3	No	-	3	ACTN2, TTN, NEB
MYPN	MYOZ2	No	-	1	ACTN2
MYPN	TNNC1	No	-	3	ACTN2, TTN, NEB
TTN	VCL	Yes	reaction, binding	15	ACTN2, TPM1, ACTN1, SOD1, HABP4, WDR1, TPM3, TUBA4A, TLN1, POTEI, PLEK, UBC, BRPF3, TPM4, TPM2
TTN	MYLK2	No	-	3	MYH14, CALM1, MYL2
TTN	LDB3	No	-	3	ACTN2, ANKRD2, ACTN1
TTN	ACTN2	Yes	binding	31	TPM1, TMOD1, TNNI1, MYL4, VCL, ACTN1, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, NEB, TLN1, MYH6, MYH8, TNNC2, TNNT1, MYPN, TNNI3, MYBPC3, MYL2, TNNC1, DES, TPM3, TNNI2, UBC, TPM4
TTN	MYBPC3	Yes	binding	27	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYBPC1, ACTN2, MYL2, TNNC1, DES, TPM3, TNNI2, TPM4
TTN	MYOZ2	No	-	2	ACTN2, ACTN1
TTN	TNNC1	Yes	binding	29	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYBPC3, ACTN2, MYL2, DES, TPM3, TNNI2, OBSCN, UBC, TPM4
VCL	MYLK2	No	-	4	MYL12B, MYL6B, MYL9, MYL6
VCL	LDB3	No	-	3	ACTN2, ACTN4, ACTN1
VCL	ACTN2	Yes	binding	31	ZYX, TNS1, CTNNA1, LPP, PXN, PTK2, ACTN4, TPM2, CTNNA3, ITGB1, RHOA, ACTN1, ACTA1, CSK, TLN1, ITGB5, TRIP6, CAPN1, ACTA2, SRC, TPM1, TTN, CTNNA2, TPM3, ITGA1, PIK3R1, CRKL, PIK3CA, UBC, TPM4, BCAR1
VCL	MYBPC3	No	-	9	ACTN2, TPM1, MYH11, TTN, TPM3, MYL9, TPM4, MYL6B, TPM2
VCL	MYOZ2	No	-	3	ACTN2, ACTN4, ACTN1
VCL	TNNC1	No	-	7	ACTN2, TPM1, TTN, TPM3, UBC, TPM4, TPM2
MYLK2	ACTN2	No	-	1	MYL2
MYLK2	MYBPC3	No	-	6	MYLPF, MYL5, MYH14, MYL9, MYL6B, MYL2
MYLK2	PLN	No	-	4	PRKACG, PRKACB, PRKACA, PRKX
MYLK2	TNNC1	No	-	2	MYH14, MYL2
LDB3	ACTN2	Yes	binding	4	ACTN4, MYOZ2, MYOZ1, ACTN1
LDB3	MYBPC3	No	-	1	ACTN2
LDB3	MYOZ2	Yes	binding	3	ACTN2, ACTN4, ACTN1
LDB3	TNNC1	No	-	1	ACTN2
ACTN2	MYBPC3	Yes	binding	27	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, TPM2, MYL1, TNNT2, MYH3, MYBPC2, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC1, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
ACTN2	MYOZ2	Yes	binding	4	PDLIM5, ACTN4, ACTN1, LDB3
ACTN2	TNNC1	Yes	binding	28	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, TPM2, MYL1, TNNT2, MYH3, MYBPC2, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC3, MYL2, TTN, TNNI1, TPM3, TNNI2, UBC, TPM4
MYBPC3	MYOZ2	No	-	1	ACTN2
MYBPC3	TNNC1	Yes	binding	28	TPM1, TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, TPM2, MYL1, TNNT2, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYH7, MYBPC1, ACTN2, MYL2, TTN, DES, TPM3, TNNI2, TPM4
MYOZ2	TNNC1	No	-	1	ACTN2
PLN	TNNC1	No	-	0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
ACTC1	TPM1	Yes	1	ACTA2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
TNNI3	TNNT2	Yes	3	TNNC1, TNNI3, TNNT2
TNNI3	TNNC1	Yes	3	TNNC1, TNNI3, TNNT2
TNNT2	TNNC1	Yes	3	TNNC1, TNNI3, TNNT2
TTN	TCAP	Yes	2	TTN, TCAP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Hypertrophic cardiomyopathy (HCM)	hsa05410	6.21	12	TPM1, TNNT2, MYL3, MYH7, TNNC1, ACTC1, PRKAG2, TNNI3, TTN, MYH6, MYBPC3, MYL2
Dilated cardiomyopathy	hsa05414	6.08	12	PLN, TPM1, TNNT2, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, MYL3, MYBPC3, MYL2
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	10	PLN, TPM1, TNNT2, MYH7, TNNC1, ACTC1, MYH6, TNNI3, MYL3, MYL2
Cardiac muscle contraction	hsa04260	6.34	9	TPM1, TNNT2, MYH7, TNNC1, ACTC1, MYH6, TNNI3, MYL3, MYL2
Focal adhesion	hsa04510	4.92	5	ACTN2, CAV3, MYL2, VCL, MYLK2
Tight junction	hsa04530	5.53	4	ACTN2, MYL2, MYH7, MYH6
Regulation of actin cytoskeleton	hsa04810	4.9	4	ACTN2, VCL, MYLK2, MYL2
cGMP-PKG signaling pathway	hsa04022	5.32	3	PLN, MYH7, MYLK2
Calcium signaling pathway	hsa04020	5.22	3	PLN, TNNC1, MYLK2
Leukocyte transendothelial migration	hsa04670	5.74	3	ACTN2, VCL, MYL2
Bacterial invasion of epithelial cells	hsa05100	6.34	2	CAV3, VCL
cAMP signaling pathway	hsa04024	5.05	2	PLN, TNNI3
Adherens junction	hsa04520	6.26	2	ACTN2, VCL
Amoebiasis	hsa05146	5.82	2	ACTN2, VCL
Viral myocarditis	hsa05416	6.45	2	MYH7, MYH6
Thyroid hormone signaling pathway	hsa04919	5.82	2	PLN, MYH6
Oxytocin signaling pathway	hsa04921	5.4	2	MYLK2, PRKAG2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Human Diseases	NEW	1.54	0.0	ACTN2, PLN, TPM1, JPH2, TNNT2, TCAP, MYH7, TTN, ACTC1, PRKAG2, CSRP3, MYH6, TNNI3, TNNC1, CAV3, VCL, LDB3, MYBPC3, MYL2, MYL3
Organismal Systems	NEW	1.33	0.021	ACTN2, PLN, TPM1, TNNT2, MYL3, MYH7, TNNC1, ACTC1, PRKAG2, TNNI3, MYLK2, VCL, MYH6, MYL2
Immune system	NEW	2.92	0.032	ACTN2, TPM1, TNNT2, MYL3, ACTC1, CSRP3, MYLK2, TNNI3, CAV3, VCL, MYH6, MYBPC3, MYL2
Cellular Processes	NEW	2.22	0.021	ACTN2, PLN, TPM1, TNNT2, TCAP, MYH7, ACTC1, CSRP3, MYH6, TNNI3, MYLK2, CAV3, VCL, LDB3, MYBPC3, MYL2, MYL3
Cardiovascular diseases	NEW	5.06	0.0	ACTN2, PLN, TPM1, TNNT2, MYL3, MYH7, TNNC1, ACTC1, PRKAG2, VCL, TNNI3, TTN, CAV3, MYH6, MYBPC3, MYL2
cGMP-PKG signaling pathway (hsa04022)	-	5.32	0.022	ACTN2, PLN, CSRP3, MYH7, CAV3, MYLK2
Cardiac muscle contraction (hsa04260)	-	6.34	0.0	ACTN2, TPM1, TNNT2, MYH7, TNNC1, ACTC1, MYH6, TNNI3, MYL3, MYL2
Calcium signaling pathway (hsa04020)	-	5.22	0.0	ACTN2, PLN, TPM1, TNNT2, TNNC1, MYLK2, CAV3, MYL2
Tight junction (hsa04530)	-	5.53	0.021	ACTN2, MYH7, MYL2, MYH6
Signal transduction	NEW	2.06	0.035	ACTN2, PLN, TPM1, TNNT2, TCAP, MYH7, TNNC1, ACTC1, CSRP3, PRKAG2, TNNI3, MYLK2, CAV3, VCL, MYBPC3, MYL2, MYL3
Leukocyte transendothelial migration (hsa04670)	-	5.74	0.003	ACTN2, TNNT2, VCL, MYH6, MYBPC3, MYL2
Circulatory system	NEW	4.63	0.0	ACTN2, PLN, TPM1, TNNT2, MYH7, TNNC1, ACTC1, CSRP3, MYH6, TNNI3, MYLK2, CAV3, MYL3, MYL2
Focal adhesion (hsa04510)	-	4.92	0.001	ACTN2, TPM1, TNNT2, MYH6, MYLK2, CAV3, VCL, MYL2
Cellular community	NEW	3.57	0.02	ACTN2, TPM1, TNNT2, MYH6, MYH7, CSRP3, MYLK2, CAV3, VCL, LDB3, MYL2
Hypertrophic cardiomyopathy (HCM) (hsa05410)	-	6.21	0.0	ACTN2, TPM1, TNNT2, MYL3, MYH7, TNNC1, ACTC1, TTN, PRKAG2, TNNI3, CAV3, MYH6, MYBPC3, MYL2
Dilated cardiomyopathy (hsa05414)	-	6.08	0.0	ACTN2, PLN, TPM1, TNNT2, MYL3, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, CAV3, MYBPC3, MYL2
Adrenergic signaling in cardiomyocytes (hsa04261)	-	5.44	0.0	ACTN2, PLN, TPM1, TNNT2, MYL3, MYH7, TNNC1, ACTC1, MYH6, TNNI3, CAV3, MYL2

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Muscle contraction	R-HSA-397014	6.96	14	ACTN2, TPM1, TNNT2, MYL3, TCAP, TTN, ACTC1, MYH6, TNNI3, TNNC1, CAV3, VCL, MYBPC3, MYL2
Striated Muscle Contraction	R-HSA-390522	7.81	12	ACTN2, TPM1, TNNT2, TCAP, TNNC1, ACTC1, MYH6, TNNI3, TTN, MYL3, MYBPC3, MYL2
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	3	ACTN2, VCL, PRKAG2
Platelet degranulation	R-HSA-114608	6.68	3	ACTN2, TTN, VCL
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	3	ACTN2, TTN, VCL
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.59	3	ACTN2, TTN, VCL
IRS-mediated signalling	R-HSA-112399	4.87	3	ACTN2, VCL, PRKAG2
Membrane Trafficking	R-HSA-199991	5.26	3	MYH7, MYH6, PRKAG2
IGF1R signaling cascade	R-HSA-2428924	4.85	3	ACTN2, VCL, PRKAG2
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	3	ACTN2, VCL, PRKAG2
Translocation of GLUT4 to the plasma membrane	R-HSA-1445148	6.77	3	MYH7, MYH6, PRKAG2
Insulin receptor signalling cascade	R-HSA-74751	4.85	3	ACTN2, VCL, PRKAG2
Signaling by Insulin receptor	R-HSA-74752	4.73	3	ACTN2, VCL, PRKAG2
Hemostasis	R-HSA-109582	3.98	3	ACTN2, TTN, VCL
Signal Transduction	R-HSA-162582	1.78	3	ACTN2, VCL, PRKAG2
Vesicle-mediated transport	R-HSA-5653656	4.33	3	MYH7, MYH6, PRKAG2
Immune System	R-HSA-168256	2.37	2	ACTN2, VCL
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	2	ACTN2, VCL
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	ACTN2, VCL
Signaling by Interleukins	R-HSA-449147	4.71	2	ACTN2, VCL
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	2	ACTN2, VCL
Frs2-mediated activation	R-HSA-170968	5.12	2	ACTN2, VCL
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	2	ACTN2, VCL
SOS-mediated signalling	R-HSA-112412	5.15	2	ACTN2, VCL
Downstream signal transduction	R-HSA-186763	4.65	2	ACTN2, VCL
Signaling by ERBB4	R-HSA-1236394	4.7	2	ACTN2, VCL
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	2	ACTN2, VCL
Developmental Biology	R-HSA-1266738	3.48	2	ACTN2, VCL
RAF/MAP kinase cascade	R-HSA-5673001	5.15	2	ACTN2, VCL
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	2	ACTN2, VCL
MAPK family signaling cascades	R-HSA-5683057	4.89	2	ACTN2, VCL
Signaling by Leptin	R-HSA-2586552	5.1	2	ACTN2, VCL
Signaling by VEGF	R-HSA-194138	4.66	2	ACTN2, VCL
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	2	ACTN2, VCL
FCERI mediated MAPK activation	R-HSA-2871796	4.32	2	ACTN2, VCL
SHC1 events in EGFR signaling	R-HSA-180336	5.15	2	ACTN2, VCL
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	2	ACTN2, VCL
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	2	ACTN2, VCL
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	2	ACTN2, VCL
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	2	ACTN2, VCL
Signaling by FGFR4	R-HSA-5654743	4.69	2	ACTN2, VCL
Signaling by FGFR3	R-HSA-5654741	4.69	2	ACTN2, VCL
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	2	ACTN2, VCL
Signaling by FGFR	R-HSA-190236	4.67	2	ACTN2, VCL
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	2	ACTN2, VCL
Interleukin-2 signaling	R-HSA-451927	5.05	2	ACTN2, VCL
Interleukin receptor SHC signaling	R-HSA-912526	5.09	2	ACTN2, VCL
Innate Immune System	R-HSA-168249	3.17	2	ACTN2, VCL
Signaling by SCF-KIT	R-HSA-1433557	4.73	2	ACTN2, VCL
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	2	ACTN2, VCL
Signaling by PDGF	R-HSA-186797	4.53	2	ACTN2, VCL
Signalling to RAS	R-HSA-167044	5.08	2	ACTN2, VCL
DAP12 signaling	R-HSA-2424491	4.64	2	ACTN2, VCL
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	2	ACTN2, VCL
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	2	ACTN2, VCL
Signaling by FGFR1	R-HSA-5654736	4.69	2	ACTN2, VCL
Signaling by EGFR	R-HSA-177929	4.59	2	ACTN2, VCL
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	2	ACTN2, VCL
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	2	ACTN2, VCL
Prolonged ERK activation events	R-HSA-169893	5.11	2	ACTN2, VCL
Signalling to ERKs	R-HSA-187687	5.04	2	ACTN2, VCL
Signalling by NGF	R-HSA-166520	4.23	2	ACTN2, VCL
Signaling by GPCR	R-HSA-372790	2.68	2	ACTN2, VCL
Signaling by FGFR2	R-HSA-5654738	4.68	2	ACTN2, VCL
GRB2 events in EGFR signaling	R-HSA-179812	5.15	2	ACTN2, VCL
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	2	ACTN2, VCL
ARMS-mediated activation	R-HSA-170984	5.12	2	ACTN2, VCL
DAP12 interactions	R-HSA-2172127	4.56	2	ACTN2, VCL
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	2	ACTN2, VCL
Signaling by ERBB2	R-HSA-1227986	4.66	2	ACTN2, VCL
Axon guidance	R-HSA-422475	3.93	2	ACTN2, VCL
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	2	ACTN2, VCL
Smooth Muscle Contraction	R-HSA-445355	8.23	2	TPM1, VCL

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Muscle contraction (R-HSA-397014)	-	6.96	0.0	ACTN2, TPM1, TNNT2, MYL3, TCAP, TNNC1, ACTC1, TTN, VCL, TNNI3, CAV3, MYH6, MYBPC3, MYL2
Smooth Muscle Contraction (R-HSA-445355)	-	8.23	0.006	TPM1, MYH6, VCL
Striated Muscle Contraction (R-HSA-390522)	-	7.81	0.0	ACTN2, TPM1, TNNT2, TCAP, TNNC1, ACTC1, MYH6, TNNI3, TTN, MYL3, MYBPC3, MYL2
Translocation of GLUT4 to the plasma membrane (R-HSA-1445148)	-	6.77	0.049	ACTN2, MYH7, MYH6, PRKAG2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	25	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, JPH2, TNNI3, MYLK2, PRKAG2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
protein binding (GO:0005515)	0.46	25	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, PRKAG2, TNNI3, MYLK2, JPH2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
cytoskeletal protein binding (GO:0008092)	3.02	20	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYPN, CSRP3, MYH6, TNNI3, TNNC1, MYOZ2, CAV3, VCL, LDB3, MYL2, MYBPC3, NEXN, MYL3
actin binding (GO:0003779)	3.74	15	ACTN2, TPM1, NEXN, TNNT2, MYL3, MYH7, TTN, MYPN, VCL, TNNI3, TNNC1, MYOZ2, MYH6, MYBPC3, MYL2
structural molecule activity (GO:0005198)	3.1	11	ACTN2, TPM1, MYL3, TCAP, TTN, CSRP3, VCL, CAV3, MYL2, MYBPC3, NEXN
ion binding (GO:0043167)	1.36	11	ACTN2, CSRP3, TNNC1, CALR3, JPH2, TNNI3, TTN, MYL3, LDB3, MYBPC3, MYL2
cation binding (GO:0043169)	1.4	10	ACTN2, CSRP3, TNNC1, CALR3, MYL3, TNNI3, TTN, LDB3, MYBPC3, MYL2
metal ion binding (GO:0046872)	1.41	10	ACTN2, CSRP3, TNNC1, CALR3, MYL3, TNNI3, TTN, LDB3, MYBPC3, MYL2
structural constituent of muscle (GO:0008307)	6.02	9	ACTN2, TPM1, TCAP, TTN, CSRP3, MYL3, NEXN, MYBPC3, MYL2
enzyme binding (GO:0019899)	2.27	9	PLN, MYH6, TTN, VCL, TNNI3, CAV3, MYOZ2, PRKAG2, LDB3
catalytic activity (GO:0003824)	1.05	8	TNNT2, MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2, MYL3
carbohydrate derivative binding (GO:0097367)	2.03	7	MYH6, MYH7, TTN, ACTC1, MYLK2, VCL, PRKAG2
identical protein binding (GO:0042802)	2.63	6	ACTN2, PLN, MYH7, TNNC1, TTN, MYBPC3
adenyl ribonucleotide binding (GO:0032559)	2.41	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
adenyl nucleotide binding (GO:0030554)	2.4	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
organic cyclic compound binding (GO:0097159)	1.05	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
nucleoside binding (GO:0001882)	2.21	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
nucleotide binding (GO:0000166)	1.96	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
small molecule binding (GO:0036094)	1.89	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
ribonucleotide binding (GO:0032553)	2.19	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
purine ribonucleoside binding (GO:0032550)	2.22	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
macromolecular complex binding (GO:0044877)	2.61	6	ACTN2, TTN, CAV3, TNNC1, VCL, NEXN
ATP binding (GO:0005524)	2.43	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
purine nucleoside binding (GO:0001883)	2.22	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
ribonucleoside binding (GO:0032549)	2.22	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
protein complex binding (GO:0032403)	3.09	6	ACTN2, TTN, CAV3, TNNC1, VCL, NEXN
purine nucleotide binding (GO:0017076)	2.19	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
molecular function regulator (GO:0098772)	2.51	6	ACTN2, PLN, CAV3, TNNI3, PRKAG2, MYBPC3
purine ribonucleotide binding (GO:0032555)	2.2	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
heterocyclic compound binding (GO:1901363)	1.06	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
nucleoside phosphate binding (GO:1901265)	1.96	6	MYH6, MYH7, TTN, ACTC1, MYLK2, PRKAG2
calcium ion binding (GO:0005509)	3.17	6	ACTN2, CALR3, TTN, MYL3, TNNC1, MYL2
hydrolase activity (GO:0016787)	1.9	5	MYH7, TNNT2, ACTC1, MYL3, MYH6
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	5	TNNT2, ACTC1, MYH7, MYH6, MYL3
pyrophosphatase activity (GO:0016462)	3.04	5	TNNT2, ACTC1, MYH7, MYH6, MYL3
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	5	MYH7, TNNT2, ACTC1, MYL3, MYH6
actin filament binding (GO:0051015)	4.93	5	ACTN2, TTN, VCL, NEXN, TNNC1
nucleoside-triphosphatase activity (GO:0017111)	3.09	5	TNNT2, ACTC1, MYH7, MYH6, MYL3
protein kinase binding (GO:0019901)	3.44	5	TTN, TNNI3, PRKAG2, LDB3, MYH6
kinase binding (GO:0019900)	3.32	5	TNNI3, TTN, PRKAG2, LDB3, MYH6
actinin binding (GO:0042805)	6.3	4	TTN, CSRP3, MYPN, LDB3
protein domain specific binding (GO:0019904)	3.32	4	ACTN2, TNNI3, MYPN, TCAP
ATPase activity (GO:0016887)	3.65	4	TNNT2, ACTC1, MYH7, MYH6
myosin binding (GO:0017022)	5.66	4	MYBPC3, ACTC1, MYL3, MYL2
calmodulin binding (GO:0005516)	4.55	4	MYH7, TTN, MYLK2, MYH6
telethonin binding (GO:0031433)	8.13	3	TTN, MYOZ2, CSRP3
titin binding (GO:0031432)	7.25	3	ACTN2, MYBPC3, TCAP
alpha-actinin binding (GO:0051393)	6.6	3	TTN, MYPN, LDB3
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	3	TTN, MYLK2, PRKAG2
protein dimerization activity (GO:0046983)	2.72	3	ACTN2, TNNC1, MYH7
enzyme regulator activity (GO:0030234)	2.85	3	PLN, MYBPC3, PRKAG2
kinase activity (GO:0016301)	2.93	3	TTN, MYLK2, PRKAG2
muscle alpha-actinin binding (GO:0051371)	7.54	3	TTN, MYPN, LDB3
protein serine/threonine kinase activity (GO:0004674)	3.64	3	TTN, MYLK2, PRKAG2
transferase activity (GO:0016740)	1.95	3	TTN, MYLK2, PRKAG2
myosin heavy chain binding (GO:0032036)	7.25	3	MYBPC3, MYL3, MYL2
protein kinase activity (GO:0004672)	3.27	3	TTN, MYLK2, PRKAG2
channel regulator activity (GO:0016247)	4.88	3	PLN, TNNI3, CAV3
calcium channel regulator activity (GO:0005246)	6.15	3	PLN, TNNI3, CAV3
ion channel binding (GO:0044325)	5.02	3	ACTN2, CAV3, TCAP
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	3	TTN, MYLK2, PRKAG2
motor activity (GO:0003774)	4.81	3	MYH7, MYH6, MYL3
protein homodimerization activity (GO:0042803)	3.16	3	ACTN2, TNNC1, MYH7
calcium-dependent protein binding (GO:0048306)	5.68	2	TNNI3, TNNC1
troponin T binding (GO:0031014)	8.35	2	TNNI3, TNNC1
troponin I binding (GO:0031013)	8.13	2	TNNC1, TNNT2
zinc ion binding (GO:0008270)	2.66	2	CSRP3, LDB3
ATPase regulator activity (GO:0060590)	6.34	2	PLN, MYBPC3
troponin C binding (GO:0030172)	8.64	2	TNNI3, TNNT2
enzyme inhibitor activity (GO:0004857)	3.78	2	PLN, PRKAG2
microfilament motor activity (GO:0000146)	6.65	2	MYH7, MYH6
transition metal ion binding (GO:0046914)	2.48	2	CSRP3, LDB3
ATPase activity, coupled (GO:0042623)	3.97	2	MYH7, MYH6
ion channel inhibitor activity (GO:0008200)	6.15	2	TNNI3, CAV3
phospholipid binding (GO:0005543)	3.91	2	ACTN2, JPH2
phosphatidylinositol-4,5-bisphosphate binding (GO:0005546)	5.81	2	ACTN2, JPH2
phosphatidylinositol bisphosphate binding (GO:1902936)	5.79	2	ACTN2, JPH2
channel inhibitor activity (GO:0016248)	6.13	2	TNNI3, CAV3
titin Z domain binding (GO:0070080)	9.05	2	ACTN2, TCAP
lipid binding (GO:0008289)	3.26	2	ACTN2, JPH2
actin-dependent ATPase activity (GO:0030898)	7.17	2	MYH7, MYH6
actin monomer binding (GO:0003785)	6.48	2	MYL3, MYL2
phosphatidylinositol phosphate binding (GO:1901981)	5.05	2	ACTN2, JPH2
cell adhesion molecule binding (GO:0050839)	4.5	2	ACTN2, VCL
nucleoside-triphosphatase regulator activity (GO:0060589)	3.92	2	PLN, MYBPC3
binding, bridging (GO:0060090)	4.57	2	TNNT2, TCAP
protein binding, bridging (GO:0030674)	4.68	2	TNNT2, TCAP
phosphatidylinositol binding (GO:0035091)	4.47	2	ACTN2, JPH2
FATZ binding (GO:0051373)	8.64	2	ACTN2, TCAP
enzyme activator activity (GO:0008047)	3.56	2	MYBPC3, PRKAG2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
structural constituent of cytoskeleton (GO:0005200)	NEW	5.12	0.034	ACTN2, TPM1, TNNT2, VCL
calcium-dependent protein binding (GO:0048306)	-	5.68	0.011	ACTN2, TNNI3, TPM1, TNNC1
troponin T binding (GO:0031014)	-	8.35	0.002	TNNI3, TNNC1
myosin binding (GO:0017022)	-	5.66	0.0	ACTN2, ACTC1, MYL3, MYH6, MYBPC3, MYL2
troponin C binding (GO:0030172)	-	8.64	0.002	TNNI3, TNNT2
ion channel binding (GO:0044325)	-	5.02	0.037	ACTN2, TPM1, CAV3, TCAP
ankyrin binding (GO:0030506)	NEW	6.74	0.01	ACTN2, TTN, CAV3
telethonin binding (GO:0031433)	-	8.13	0.0	ACTN2, TTN, MYOZ2, CSRP3, MYH6
titin binding (GO:0031432)	-	7.25	0.0	ACTN2, MYBPC3, MYPN, TCAP
microfilament motor activity (GO:0000146)	-	6.65	0.0	ACTN2, ACTC1, MYH7, MYH6
structural molecule activity (GO:0005198)	-	3.1	0.0	ACTN2, TPM1, JPH2, MYH6, TCAP, NEXN, ACTC1, CSRP3, VCL, CAV3, TTN, MYPN, TNNT2, MYBPC3, MYL2, MYL3
actin binding (GO:0003779)	-	3.74	0.0	ACTN2, TPM1, NEXN, TNNT2, TCAP, MYH7, TTN, ACTC1, CSRP3, MYH6, TNNI3, TNNC1, MYOZ2, CAV3, VCL, LDB3, MYPN, MYBPC3, MYL2, MYL3
protein serine/threonine kinase activity (GO:0004674)	-	3.64	0.009	ACTN2, TTN, ACTC1, MYLK2, TNNI3, TNNC1, CAV3, MYH6, NEXN
transferase activity (GO:0016740)	-	1.95	0.014	ACTN2, PLN, CSRP3, TNNT2, MYH7, TTN, ACTC1, NEXN, MYLK2, TNNI3, TNNC1, VCL, CAV3, MYH6, LDB3, MYBPC3, MYL2
calcium ion binding (GO:0005509)	-	3.17	0.0	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, CSRP3, MYH6, TNNI3, TNNC1, CAV3, CALR3, MYPN, MYBPC3, MYL2, MYL3
channel inhibitor activity (GO:0016248)	-	6.13	0.044	ACTN2, TNNI3, CAV3
protein complex binding (GO:0032403)	-	3.09	0.013	ACTN2, TPM1, TNNC1, ACTC1, VCL, TNNI3, TTN, CAV3, PRKAG2, MYPN, MYBPC3, NEXN
actinin binding (GO:0042805)	-	6.3	0.0	ACTN2, CSRP3, TTN, MYPN, VCL, LDB3
motor activity (GO:0003774)	-	4.81	0.009	ACTN2, MYH7, ACTC1, MYL3, MYH6
ATP binding (GO:0005524)	-	2.43	0.012	ACTN2, PLN, CSRP3, TNNT2, MYH7, TNNC1, ACTC1, TTN, PRKAG2, TNNI3, MYLK2, VCL, CAV3, MYH6, MYBPC3
protein homodimerization activity (GO:0042803)	-	3.16	0.031	ACTN2, TPM1, MYH7, TNNC1, ACTC1, CALR3, VCL, TNNI3, CAV3, MYH6, MYL2
myosin heavy chain binding (GO:0032036)	-	7.25	0.0	MYBPC3, MYL3, MYL2
alpha-actinin binding (GO:0051393)	-	6.6	0.0	TTN, ACTN2, VCL, MYPN, LDB3
titin Z domain binding (GO:0070080)	-	9.05	0.0	ACTN2, TCAP
kinase activity (GO:0016301)	-	2.93	0.032	ACTN2, PLN, CSRP3, TNNC1, ACTC1, TTN, MYLK2, TNNI3, CAV3, MYH6, NEXN
actin filament binding (GO:0051015)	-	4.93	0.0	ACTN2, TTN, ACTC1, MYPN, TNNC1, VCL, MYBPC3, NEXN
protein kinase binding (GO:0019901)	-	3.44	0.0	ACTN2, PLN, TPM1, MYH6, TCAP, TTN, VCL, TNNI3, CAV3, PRKAG2, LDB3
kinase binding (GO:0019900)	-	3.32	0.001	ACTN2, PLN, TPM1, MYH6, TCAP, TTN, VCL, TNNI3, CAV3, PRKAG2, LDB3
troponin I binding (GO:0031013)	-	8.13	0.0	TNNI3, TNNC1, TNNT2
phosphatase binding (GO:0019902)	NEW	4.63	0.047	ACTN2, MYOZ2, ACTC1, TPM1, VCL
actin monomer binding (GO:0003785)	-	6.48	0.034	MYL3, MYL2
tropomyosin binding (GO:0005523)	NEW	7.1	0.0	ACTN2, TPM1, TNNT2, MYPN
ion channel inhibitor activity (GO:0008200)	-	6.15	0.042	ACTN2, TNNI3, CAV3
binding, bridging (GO:0060090)	-	4.57	0.009	ACTN2, TPM1, TCAP, CAV3, VCL, MYBPC3
actin-dependent ATPase activity (GO:0030898)	-	7.17	0.015	ACTN2, ACTC1, MYH7, MYH6
protein binding, bridging (GO:0030674)	-	4.68	0.005	ACTN2, TPM1, TCAP, CAV3, VCL, MYBPC3
cytoskeletal protein binding (GO:0008092)	-	3.02	0.0	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, PRKAG2, CSRP3, MYH6, TNNI3, TNNC1, MYOZ2, CAV3, VCL, LDB3, MYL2, MYPN, MYBPC3, NEXN, MYL3
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	-	3.08	0.011	ACTN2, PLN, CSRP3, TNNC1, ACTC1, TTN, MYLK2, TNNI3, CAV3, MYH6, NEXN
FATZ binding (GO:0051373)	-	8.64	0.002	ACTN2, TCAP
muscle alpha-actinin binding (GO:0051371)	-	7.54	0.0	ACTN2, TTN, VCL, MYPN, LDB3
structural constituent of muscle (GO:0008307)	-	6.02	0.0	ACTN2, TPM1, TCAP, MYH7, TTN, CSRP3, MYPN, NEXN, MYBPC3, MYL2, MYL3
adenyl nucleotide binding (GO:0030554)	-	2.4	0.017	ACTN2, PLN, CSRP3, TNNT2, MYH7, TTN, ACTC1, PRKAG2, TNNI3, MYLK2, VCL, CAV3, MYH6, TNNC1, MYBPC3
calmodulin binding (GO:0005516)	-	4.55	0.0	ACTN2, TPM1, MYH7, TTN, MYLK2, CAV3, MYH6
protein binding (GO:0005515)	-	0.46	0.0	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, PRKAG2, TNNI3, MYLK2, JPH2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
calcium channel regulator activity (GO:0005246)	-	6.15	0.002	PLN, TNNI3, CAV3
protein dimerization activity (GO:0046983)	-	2.72	0.012	ACTN2, TPM1, MYH6, MYH7, TNNC1, ACTC1, CSRP3, VCL, TNNI3, CAV3, CALR3, PRKAG2, LDB3, MYL2
protein domain specific binding (GO:0019904)	-	3.32	0.011	ACTN2, TPM1, MYL3, TCAP, ACTC1, VCL, TNNI3, CAV3, MYPN, MYBPC3, MYL2

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	24	TPM1, TCAP, VCL, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, JPH2, TNNI3, MYLK2, PRKAG2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
single-organism cellular process (GO:0044763)	0.65	24	TPM1, TCAP, VCL, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, PRKAG2, TNNI3, MYLK2, JPH2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
single-organism process (GO:0044699)	0.48	24	TPM1, TCAP, VCL, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, JPH2, TNNI3, MYLK2, PRKAG2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
biological regulation (GO:0065007)	0.39	20	ACTN2, PLN, TPM1, JPH2, TNNT2, MYL3, MYH7, TNNC1, PRKAG2, ACTC1, CSRP3, VCL, TNNI3, MYLK2, TTN, CAV3, MYH6, MYL2, MYBPC3, NEXN
regulation of biological process (GO:0050789)	0.45	20	ACTN2, PLN, TPM1, JPH2, TNNT2, MYL3, MYH7, TTN, ACTC1, NEXN, PRKAG2, CSRP3, MYH6, TNNI3, TNNC1, VCL, CAV3, MYLK2, MYBPC3, MYL2
developmental process (GO:0032502)	1.36	19	ACTN2, PLN, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, CSRP3, VCL, TNNC1, TNNI3, MYLK2, CAV3, MYH6, MYL2, MYBPC3, NEXN, MYL3
single-organism developmental process (GO:0044767)	1.49	18	ACTN2, TPM1, TTN, TNNT2, TCAP, MYH7, TNNC1, ACTC1, CSRP3, MYH6, TNNI3, CAV3, VCL, MYLK2, MYL2, MYBPC3, NEXN, MYL3
muscle system process (GO:0003012)	4.18	18	ACTN2, PLN, TPM1, TTN, TNNT2, TCAP, MYH7, TNNC1, ACTC1, CSRP3, MYH6, TNNI3, CAV3, VCL, MYLK2, MYBPC3, MYL2, MYL3
multicellular organismal process (GO:0032501)	1.45	18	ACTN2, PLN, TPM1, TTN, TNNT2, TCAP, MYH7, TNNC1, ACTC1, CSRP3, MYH6, TNNI3, CAV3, VCL, MYLK2, MYBPC3, MYL2, MYL3
system process (GO:0003008)	2.3	18	ACTN2, PLN, TPM1, TNNT2, TCAP, MYH7, TNNC1, ACTC1, CSRP3, VCL, TNNI3, MYLK2, TTN, CAV3, MYH6, MYBPC3, MYL2, MYL3
muscle contraction (GO:0006936)	4.37	17	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, CSRP3, MYLK2, TNNI3, CAV3, VCL, MYH6, TNNC1, MYBPC3, MYL2, MYL3
regulation of cellular process (GO:0050794)	0.5	17	ACTN2, PLN, CSRP3, JPH2, TNNT2, TNNC1, NEXN, ACTC1, TPM1, MYH6, MYLK2, TTN, CAV3, PRKAG2, VCL, MYBPC3, MYL2
actin filament-based process (GO:0030029)	3.94	16	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, CSRP3, MYH6, TNNI3, TNNC1, MYPN, LDB3, MYBPC3, MYL2, MYL3
regulation of multicellular organismal process (GO:0051239)	1.87	14	PLN, TPM1, TNNT2, MYL3, MYH7, TNNC1, CSRP3, MYLK2, TNNI3, JPH2, CAV3, MYH6, MYBPC3, MYL2
cellular component organization (GO:0016043)	1.24	14	ACTN2, PLN, TPM1, TNNT2, TCAP, TTN, ACTC1, CSRP3, MYPN, CAV3, VCL, MYH6, LDB3, MYL2
movement of cell or subcellular component (GO:0006928)	2.61	14	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYH6, TNNI3, TNNC1, VCL, MYBPC3, MYL2, MYL3
striated muscle contraction (GO:0006941)	5.37	14	TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, CSRP3, MYH6, TNNI3, TNNC1, MYLK2, MYBPC3, MYL2, MYL3
tissue morphogenesis (GO:0048729)	3.87	14	TPM1, TNNT2, TCAP, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, VCL, MYLK2, MYBPC3, MYL2, MYL3
anatomical structure morphogenesis (GO:0009653)	2.53	14	TPM1, TNNT2, TCAP, MYH7, TNNC1, ACTC1, MYLK2, TNNI3, TTN, VCL, MYH6, MYBPC3, MYL2, MYL3
cardiac muscle contraction (GO:0060048)	5.88	14	TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, CSRP3, MYH6, TNNI3, TNNC1, MYLK2, MYBPC3, MYL2, MYL3
cellular component organization or biogenesis (GO:0071840)	1.22	14	ACTN2, PLN, TPM1, TNNT2, TCAP, TTN, ACTC1, CSRP3, VCL, CAV3, MYH6, LDB3, MYPN, MYL2
regulation of system process (GO:0044057)	3.53	13	PLN, TPM1, TNNT2, MYL3, MYH7, TNNC1, CSRP3, MYLK2, TNNI3, CAV3, MYH6, MYBPC3, MYL2
cardiac muscle tissue morphogenesis (GO:0055008)	5.8	13	TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYH6, TNNI3, TNNC1, MYLK2, MYBPC3, MYL2, MYL3
anatomical structure development (GO:0048856)	1.58	13	ACTN2, PLN, TPM1, TCAP, MYH7, TTN, CSRP3, MYH6, TNNI3, CAV3, MYL2, NEXN, MYL3
muscle filament sliding (GO:0030049)	6.09	13	ACTN2, TPM1, TNNT2, TCAP, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, MYL3, MYBPC3, MYL2
actin filament-based movement (GO:0030048)	5.54	13	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYH6, TNNI3, TNNC1, MYL3, MYBPC3, MYL2
actin-myosin filament sliding (GO:0033275)	6.09	13	ACTN2, TPM1, TNNT2, TCAP, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, MYL3, MYBPC3, MYL2
regulation of molecular function (GO:0065009)	1.78	13	ACTN2, PLN, TPM1, TNNT2, MYH6, TNNC1, TTN, JPH2, TNNI3, CAV3, PRKAG2, MYBPC3, MYL3
regulation of biological quality (GO:0065008)	1.68	13	ACTN2, PLN, TPM1, TNNT2, MYL3, MYH7, TNNC1, CSRP3, MYH6, TNNI3, CAV3, JPH2, MYL2
actin-mediated cell contraction (GO:0070252)	5.88	13	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYH6, TNNI3, TNNC1, MYL3, MYBPC3, MYL2
muscle tissue morphogenesis (GO:0060415)	5.62	13	TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYH6, TNNI3, TNNC1, MYLK2, MYBPC3, MYL2, MYL3
regulation of localization (GO:0032879)	1.94	12	ACTN2, PLN, TPM1, TNNT2, TNNC1, MYLK2, JPH2, VCL, CAV3, PRKAG2, MYBPC3, NEXN
regulation of catalytic activity (GO:0050790)	1.97	12	ACTN2, PLN, TPM1, TNNT2, MYL3, TTN, PRKAG2, TNNI3, TNNC1, CAV3, MYH6, MYBPC3
organelle organization (GO:0006996)	2.02	11	ACTN2, TPM1, TCAP, TTN, ACTC1, CSRP3, MYH6, CAV3, MYPN, LDB3, MYL2
cellular component assembly (GO:0022607)	2.14	11	ACTN2, PLN, CSRP3, TNNT2, TCAP, TTN, ACTC1, VCL, CAV3, MYH6, MYL2
cytoskeleton organization (GO:0007010)	3.22	11	ACTN2, TPM1, TCAP, TTN, ACTC1, CSRP3, MYH6, CAV3, MYPN, LDB3, MYL2
regulation of muscle contraction (GO:0006937)	4.75	11	PLN, TPM1, TNNT2, MYH7, TNNC1, MYLK2, TNNI3, CAV3, MYL3, MYBPC3, MYL2
cellular developmental process (GO:0048869)	1.82	11	ACTN2, CSRP3, MYH6, TCAP, TTN, CALR3, MYLK2, TNNI3, CAV3, NEXN, MYL2
single-organism organelle organization (GO:1902589)	2.68	11	ACTN2, TPM1, TCAP, TTN, ACTC1, CSRP3, MYH6, CAV3, MYPN, LDB3, MYL2
regulation of muscle system process (GO:0090257)	4.51	11	PLN, TPM1, TNNT2, MYH7, TNNC1, MYLK2, TNNI3, CAV3, MYL3, MYBPC3, MYL2
negative regulation of biological process (GO:0048519)	1.33	10	ACTN2, PLN, TPM1, PRKAG2, ACTC1, CSRP3, JPH2, CAV3, VCL, MYL2
regulation of heart contraction (GO:0008016)	4.35	10	PLN, TPM1, TNNT2, MYL3, MYH7, CSRP3, MYH6, TNNI3, CAV3, MYL2
regulation of blood circulation (GO:1903522)	4.05	10	PLN, TPM1, TNNT2, MYH7, CSRP3, MYH6, TNNI3, CAV3, MYL3, MYL2
actomyosin structure organization (GO:0031032)	5.4	10	ACTN2, TPM1, TCAP, TTN, ACTC1, CSRP3, MYH6, MYPN, LDB3, MYL2
actin cytoskeleton organization (GO:0030036)	4.1	10	ACTN2, TPM1, TCAP, TTN, ACTC1, CSRP3, MYH6, MYPN, LDB3, MYL2
regulation of hydrolase activity (GO:0051336)	2.53	9	ACTN2, PLN, TPM1, TNNT2, TNNC1, MYH6, TNNI3, MYL3, MYBPC3
ventricular cardiac muscle tissue morphogenesis (GO:0055010)	6.07	9	TPM1, TNNT2, MYH7, TNNC1, MYL3, TNNI3, MYH6, MYBPC3, MYL2
regulation of transport (GO:0051049)	2.24	9	ACTN2, PLN, TNNT2, TNNC1, PRKAG2, JPH2, CAV3, MYLK2, MYBPC3
response to stimulus (GO:0050896)	1.22	9	PLN, TPM1, TNNT2, TCAP, TTN, ACTC1, CSRP3, CAV3, TNNC1
regulation of actin filament-based process (GO:0032970)	3.97	9	ACTN2, PLN, TPM1, TNNT2, TNNC1, CSRP3, MYLK2, CAV3, MYBPC3
negative regulation of cellular process (GO:0048523)	1.41	9	ACTN2, TPM1, PRKAG2, ACTC1, CSRP3, JPH2, CAV3, VCL, MYL2
regulation of ATPase activity (GO:0043462)	5.59	8	PLN, TPM1, TNNT2, TNNC1, MYH6, TNNI3, MYL3, MYBPC3
single-multicellular organism process (GO:0044707)	1.78	8	PLN, TPM1, TCAP, TNNC1, ACTC1, CSRP3, MYH6, MYL2
regulation of metabolic process (GO:0019222)	1.02	8	ACTN2, CSRP3, MYH6, TTN, ACTC1, MYLK2, CAV3, PRKAG2
regulation of macromolecule metabolic process (GO:0060255)	1.08	8	ACTN2, CSRP3, MYH6, TTN, ACTC1, MYLK2, CAV3, PRKAG2
regulation of cellular localization (GO:0060341)	3.03	8	ACTN2, PLN, TNNT2, TNNC1, JPH2, CAV3, MYLK2, MYBPC3
regulation of cellular component movement (GO:0051270)	3.08	8	PLN, TPM1, TNNT2, TNNC1, VCL, MYLK2, MYBPC3, NEXN
positive regulation of biological process (GO:0048518)	1.2	8	ACTN2, TPM1, PRKAG2, ACTC1, CSRP3, JPH2, CAV3, MYLK2
localization (GO:0051179)	1.4	8	ACTN2, PLN, CSRP3, PRKAG2, TTN, JPH2, CAV3, VCL
muscle cell development (GO:0055001)	5.29	7	ACTN2, TCAP, TTN, NEXN, CAV3, MYH6, MYL2
striated muscle cell development (GO:0055002)	5.42	7	ACTN2, TCAP, TTN, NEXN, CAV3, MYH6, MYL2
metabolic process (GO:0008152)	0.58	7	ACTN2, MYH6, MYH7, TTN, MYLK2, CAV3, PRKAG2
primary metabolic process (GO:0044238)	0.69	7	ACTN2, MYH6, MYH7, TTN, MYLK2, CAV3, PRKAG2
cell development (GO:0048468)	3.28	7	ACTN2, MYH6, TCAP, TTN, CAV3, NEXN, MYL2
transport (GO:0006810)	1.51	7	ACTN2, PLN, PRKAG2, TTN, JPH2, CAV3, VCL
regulation of response to stimulus (GO:0048583)	1.54	7	ACTN2, PLN, MYH7, TNNC1, JPH2, CAV3, PRKAG2
cellular metabolic process (GO:0044237)	0.69	7	ACTN2, MYH6, MYH7, TTN, MYLK2, CAV3, PRKAG2
organic substance metabolic process (GO:0071704)	0.63	7	ACTN2, MYH6, MYH7, TTN, MYLK2, CAV3, PRKAG2
animal organ development (GO:0048513)	2.53	7	CSRP3, TCAP, MYH7, MYH6, TNNI3, CAV3, MYL2
sarcomere organization (GO:0045214)	6.4	7	ACTN2, TPM1, TCAP, TTN, MYPN, MYH6, LDB3
positive regulation of molecular function (GO:0044093)	2.23	7	ACTN2, TPM1, TNNT2, MYL3, JPH2, PRKAG2, MYBPC3
establishment of localization (GO:0051234)	1.48	7	ACTN2, PLN, PRKAG2, TTN, JPH2, CAV3, VCL
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	7	CSRP3, TCAP, TTN, ACTC1, MYH6, CAV3, MYL2
regulation of signaling (GO:0023051)	1.72	6	ACTN2, PLN, PRKAG2, CAV3, TNNI3, JPH2
macromolecule metabolic process (GO:0043170)	0.83	6	ACTN2, PRKAG2, MYH6, TTN, MYLK2, CAV3
cardiac muscle cell development (GO:0055013)	6.4	6	ACTN2, TCAP, TTN, CAV3, MYH6, NEXN
cellular macromolecule metabolic process (GO:0044260)	0.93	6	ACTN2, PRKAG2, MYH6, TTN, MYLK2, CAV3
cardiac cell development (GO:0055006)	6.33	6	ACTN2, TCAP, TTN, CAV3, MYH6, NEXN
myofibril assembly (GO:0030239)	6.43	6	CSRP3, TCAP, TTN, ACTC1, MYH6, MYL2
regulation of cellular metabolic process (GO:0031323)	1.07	6	ACTN2, CSRP3, MYH6, TTN, CAV3, PRKAG2
phosphorus metabolic process (GO:0006793)	2.15	6	ACTN2, MYH6, MYH7, TTN, MYLK2, PRKAG2
regulation of primary metabolic process (GO:0080090)	1.08	6	ACTN2, CSRP3, MYH6, TTN, CAV3, PRKAG2
phosphate-containing compound metabolic process (GO:0006796)	2.16	6	ACTN2, MYH6, MYH7, TTN, MYLK2, PRKAG2
cellular component assembly involved in morphogenesis (GO:0010927)	4.29	6	CSRP3, TCAP, TTN, ACTC1, MYH6, MYL2
regulation of the force of heart contraction (GO:0002026)	6.4	6	PLN, CSRP3, MYH7, MYH6, MYL3, MYL2
single-organism transport (GO:0044765)	2.18	6	ACTN2, PRKAG2, TTN, CAV3, VCL, JPH2
regulation of striated muscle contraction (GO:0006942)	5.38	6	PLN, MYH7, CAV3, MYL3, MYBPC3, MYL2
positive regulation of catalytic activity (GO:0043085)	2.4	6	ACTN2, TPM1, TNNT2, PRKAG2, MYL3, MYBPC3
negative regulation of molecular function (GO:0044092)	2.74	6	ACTN2, PLN, TNNT2, CAV3, TNNI3, PRKAG2
response to chemical (GO:0042221)	1.98	6	PLN, TPM1, TNNT2, TNNC1, ACTC1, TTN
organelle assembly (GO:0070925)	3.75	6	CSRP3, TCAP, TTN, ACTC1, MYH6, MYL2
single-organism localization (GO:1902578)	2.09	6	ACTN2, PRKAG2, TTN, CAV3, VCL, JPH2
positive regulation of cellular process (GO:0048522)	1.3	6	ACTN2, CSRP3, PRKAG2, TPM1, CAV3, JPH2
cellular metal ion homeostasis (GO:0006875)	3.75	5	PLN, TNNI3, CSRP3, CAV3, JPH2
heart development (GO:0007507)	4.24	5	MYH7, MYL2, TNNI3, MYH6, TCAP
positive regulation of metabolic process (GO:0009893)	1.74	5	CAV3, CSRP3, ACTC1, MYLK2, PRKAG2
macromolecular complex subunit organization (GO:0043933)	2.14	5	PLN, TTN, TNNT2, ACTN2, TCAP
regulation of intracellular transport (GO:0032386)	3.58	5	PLN, TNNC1, MYBPC3, TNNT2, MYLK2
cell differentiation (GO:0030154)	2.14	5	TNNI3, CAV3, CSRP3, CALR3, MYLK2
regulation of cellular component organization (GO:0051128)	2.01	5	ACTN2, TPM1, NEXN, CAV3, MYL2
homeostatic process (GO:0042592)	2.61	5	PLN, TNNI3, CSRP3, CAV3, JPH2
calcium ion homeostasis (GO:0055074)	3.97	5	PLN, TNNI3, CSRP3, CAV3, JPH2
inorganic ion homeostasis (GO:0098771)	3.43	5	PLN, TNNI3, CSRP3, CAV3, JPH2
regulation of cell communication (GO:0010646)	1.73	5	PLN, CAV3, ACTN2, PRKAG2, JPH2
negative regulation of catalytic activity (GO:0043086)	3.0	5	PLN, TNNI3, TNNT2, CAV3, PRKAG2
cellular protein metabolic process (GO:0044267)	1.63	5	ACTN2, TTN, MYLK2, PRKAG2, MYH6
single-organism metabolic process (GO:0044710)	1.63	5	ACTN2, CAV3, MYH7, MYH6, PRKAG2
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	5	CAV3, CSRP3, ACTC1, MYLK2, PRKAG2
positive regulation of hydrolase activity (GO:0051345)	2.91	5	ACTN2, MYBPC3, TNNT2, TPM1, MYL3
regulation of signal transduction (GO:0009966)	1.84	5	PLN, CAV3, ACTN2, PRKAG2, JPH2
macromolecular complex assembly (GO:0065003)	2.55	5	ACTN2, TTN, TNNT2, TCAP, PLN
regulation of heart rate (GO:0002027)	5.29	5	PLN, CAV3, TPM1, MYH7, MYH6
muscle fiber development (GO:0048747)	5.8	5	TTN, NEXN, MYL2, TCAP, MYH6
ion homeostasis (GO:0050801)	3.42	5	PLN, TNNI3, CSRP3, CAV3, JPH2
cellular homeostasis (GO:0019725)	3.23	5	PLN, TNNI3, CSRP3, CAV3, JPH2
cardiac myofibril assembly (GO:0055003)	7.02	5	TTN, CSRP3, ACTC1, MYL2, TCAP
regulation of actin filament-based movement (GO:1903115)	6.33	5	PLN, TNNC1, MYBPC3, TNNT2, MYLK2
divalent inorganic cation homeostasis (GO:0072507)	3.9	5	PLN, TNNI3, CSRP3, CAV3, JPH2
regulation of developmental process (GO:0050793)	2.1	5	CAV3, CSRP3, MYH6, JPH2, TPM1
cellular calcium ion homeostasis (GO:0006874)	4.01	5	PLN, TNNI3, CSRP3, CAV3, JPH2
protein complex assembly (GO:0006461)	2.78	5	PLN, TTN, TNNT2, ACTN2, TCAP
cellular ion homeostasis (GO:0006873)	3.57	5	PLN, TNNI3, CSRP3, CAV3, JPH2
macromolecule modification (GO:0043412)	1.73	5	TTN, ACTN2, PRKAG2, MYLK2, MYH6
protein modification process (GO:0036211)	1.79	5	ACTN2, TTN, MYLK2, PRKAG2, MYH6
cellular protein modification process (GO:0006464)	1.79	5	TTN, ACTN2, PRKAG2, MYLK2, MYH6
cellular cation homeostasis (GO:0030003)	3.6	5	PLN, TNNI3, CSRP3, CAV3, JPH2
metal ion homeostasis (GO:0055065)	3.61	5	PLN, TNNI3, CSRP3, CAV3, JPH2
cation homeostasis (GO:0055080)	3.46	5	PLN, TNNI3, CSRP3, CAV3, JPH2
cellular chemical homeostasis (GO:0055082)	3.4	5	PLN, TNNI3, CSRP3, CAV3, JPH2
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	5	PLN, TNNI3, CSRP3, CAV3, JPH2
actin filament organization (GO:0007015)	4.54	5	TTN, TNNT2, ACTC1, CAV3, TCAP
protein complex subunit organization (GO:0071822)	2.6	5	PLN, TTN, TNNT2, ACTN2, TCAP
protein metabolic process (GO:0019538)	1.45	5	ACTN2, TTN, MYLK2, PRKAG2, MYH6
chemical homeostasis (GO:0048878)	2.97	5	PLN, TNNI3, CSRP3, CAV3, JPH2
regulation of ion transmembrane transporter activity (GO:0032412)	4.55	4	ACTN2, PLN, CAV3, JPH2
regulation of organelle organization (GO:0033043)	2.72	4	ACTN2, TPM1, CAV3, NEXN
phosphorylation (GO:0016310)	2.63	4	ACTN2, TTN, MYLK2, PRKAG2
detection of abiotic stimulus (GO:0009582)	4.96	4	TTN, CSRP3, CAV3, TCAP
circulatory system process (GO:0003013)	4.38	4	TNNI3, PLN, ACTC1, MYL2
signal transduction (GO:0007165)	1.28	4	PLN, ACTN2, MYH6, PRKAG2
regulation of ion transmembrane transport (GO:0034765)	3.77	4	PLN, ACTN2, CAV3, JPH2
regulation of ion transport (GO:0043269)	3.4	4	PLN, ACTN2, CAV3, JPH2
response to muscle stretch (GO:0035994)	6.78	4	TTN, CSRP3, CAV3, TCAP
detection of muscle stretch (GO:0035995)	8.34	4	TTN, CSRP3, CAV3, TCAP
regulation of intracellular signal transduction (GO:1902531)	2.31	4	PLN, CAV3, PRKAG2, JPH2
detection of mechanical stimulus (GO:0050982)	5.94	4	TTN, CSRP3, CAV3, TCAP
regulation of cytoskeleton organization (GO:0051493)	3.72	4	ACTN2, TPM1, NEXN, CAV3
response to mechanical stimulus (GO:0009612)	4.41	4	TTN, CSRP3, CAV3, TCAP
regulation of transporter activity (GO:0032409)	4.45	4	PLN, ACTN2, CAV3, JPH2
regulation of transmembrane transport (GO:0034762)	3.74	4	PLN, ACTN2, CAV3, JPH2
regulation of cellular biosynthetic process (GO:0031326)	1.38	4	ACTN2, CSRP3, MYH6, PRKAG2
regulation of receptor activity (GO:0010469)	4.98	4	ACTN2, PLN, CAV3, JPH2
regulation of gene expression (GO:0010468)	1.37	4	CSRP3, ACTC1, MYH6, MYLK2
detection of external stimulus (GO:0009581)	4.98	4	TTN, CSRP3, CAV3, TCAP
protein phosphorylation (GO:0006468)	2.89	4	ACTN2, TTN, MYLK2, PRKAG2
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	4	ACTN2, CSRP3, MYH6, PRKAG2
positive regulation of ATPase activity (GO:0032781)	5.99	4	MYBPC3, TNNT2, TPM1, MYL3
regulation of muscle filament sliding (GO:0032971)	8.34	4	TNNC1, MYBPC3, TNNT2, MYLK2
regulation of biosynthetic process (GO:0009889)	1.37	4	ACTN2, CSRP3, MYH6, PRKAG2
regulation of metal ion transport (GO:0010959)	3.94	4	PLN, ACTN2, CAV3, JPH2
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	ACTN2, CSRP3, MYH6, PRKAG2
response to metal ion (GO:0010038)	3.91	4	PLN, TTN, TNNT2, TNNC1
response to inorganic substance (GO:0010035)	3.56	4	PLN, TNNC1, TNNT2, TTN
skeletal muscle contraction (GO:0003009)	6.33	4	TNNI3, TNNC1, MYH7, TCAP
cellular localization (GO:0051641)	2.32	4	CAV3, CSRP3, VCL, PRKAG2
response to abiotic stimulus (GO:0009628)	2.8	4	TTN, CSRP3, CAV3, TCAP
detection of stimulus (GO:0051606)	3.22	4	TTN, CSRP3, CAV3, TCAP
vesicle-mediated transport (GO:0016192)	2.72	4	ACTN2, TTN, CAV3, VCL
response to external stimulus (GO:0009605)	2.55	4	TTN, CSRP3, CAV3, TCAP
regulation of transmembrane transporter activity (GO:0022898)	4.52	4	PLN, ACTN2, CAV3, JPH2
regulation of cation transmembrane transport (GO:1904062)	4.4	4	PLN, ACTN2, CAV3, JPH2
cardiac muscle fiber development (GO:0048739)	7.65	4	TTN, NEXN, MYH6, TCAP
protein localization (GO:0008104)	2.36	3	CSRP3, CAV3, VCL
regulation of phosphate metabolic process (GO:0019220)	2.35	3	TTN, CAV3, PRKAG2
regulation of homeostatic process (GO:0032844)	3.65	3	PLN, CAV3, JPH2
purine ribonucleoside monophosphate metabolic process (GO:0009167)	4.7	3	MYH7, MYH6, PRKAG2
small molecule metabolic process (GO:0044281)	2.38	3	MYH7, MYH6, PRKAG2
ribonucleoside monophosphate metabolic process (GO:0009161)	4.62	3	MYH7, MYH6, PRKAG2
negative regulation of ion transmembrane transport (GO:0034766)	5.47	3	ACTN2, PLN, CAV3
organic cyclic compound metabolic process (GO:1901360)	1.26	3	MYH7, MYH6, PRKAG2
negative regulation of transmembrane transport (GO:0034763)	5.38	3	ACTN2, PLN, CAV3
muscle organ development (GO:0007517)	4.98	3	CSRP3, CAV3, MYH6
cellular macromolecule localization (GO:0070727)	3.1	3	CSRP3, CAV3, VCL
positive regulation of cytoskeleton organization (GO:0051495)	4.58	3	ACTN2, TPM1, CAV3
ribonucleoside triphosphate metabolic process (GO:0009199)	4.77	3	MYH7, MYH6, PRKAG2
macromolecule localization (GO:0033036)	2.34	3	CSRP3, CAV3, VCL
purine ribonucleoside triphosphate metabolic process (GO:0009205)	4.81	3	MYH7, MYH6, PRKAG2
negative regulation of transport (GO:0051051)	3.6	3	ACTN2, PLN, CAV3
positive regulation of transport (GO:0051050)	2.9	3	ACTN2, CAV3, JPH2
negative regulation of ATPase activity (GO:0032780)	7.16	3	PLN, TNNI3, TNNT2
ATP metabolic process (GO:0046034)	4.98	3	MYH7, MYH6, PRKAG2
regulation of protein kinase activity (GO:0045859)	3.15	3	TTN, CAV3, PRKAG2
regulation of RNA biosynthetic process (GO:2001141)	1.55	3	ACTN2, CSRP3, MYH6
purine ribonucleoside metabolic process (GO:0046128)	4.33	3	MYH7, MYH6, PRKAG2
regulation of calcium ion import (GO:0090279)	5.08	3	PLN, CAV3, JPH2
heterocycle metabolic process (GO:0046483)	1.31	3	MYH7, MYH6, PRKAG2
regulation of phosphorylation (GO:0042325)	2.5	3	TTN, CAV3, PRKAG2
organonitrogen compound metabolic process (GO:1901564)	2.32	3	MYH7, MYH6, PRKAG2
positive regulation of organelle organization (GO:0010638)	3.38	3	ACTN2, TPM1, CAV3
purine nucleotide metabolic process (GO:0006163)	4.09	3	MYH7, MYH6, PRKAG2
organophosphate metabolic process (GO:0019637)	3.04	3	MYH7, MYH6, PRKAG2
heart process (GO:0003015)	7.02	3	TNNI3, ACTC1, MYL2
regulation of membrane potential (GO:0042391)	3.89	3	PLN, ACTN2, CAV3
negative regulation of transporter activity (GO:0032410)	5.59	3	PLN, ACTN2, CAV3
negative regulation of ion transmembrane transporter activity (GO:0032413)	5.74	3	ACTN2, PLN, CAV3
nucleoside triphosphate metabolic process (GO:0009141)	4.61	3	MYH7, MYH6, PRKAG2
purine nucleoside triphosphate metabolic process (GO:0009144)	4.76	3	MYH7, MYH6, PRKAG2
secretion by cell (GO:0032940)	3.59	3	ACTN2, TTN, VCL
positive regulation of gene expression (GO:0010628)	2.35	3	CSRP3, ACTC1, MYLK2
intracellular signal transduction (GO:0035556)	2.39	3	PLN, ACTN2, PRKAG2
negative regulation of hydrolase activity (GO:0051346)	3.74	3	PLN, TNNI3, TNNT2
exocytosis (GO:0006887)	4.11	3	ACTN2, TTN, VCL
regulated exocytosis (GO:0045055)	4.44	3	ACTN2, TTN, VCL
positive regulation of cellular component organization (GO:0051130)	2.68	3	ACTN2, TPM1, CAV3
ion transport (GO:0006811)	2.66	3	PLN, PRKAG2, JPH2
tissue development (GO:0009888)	3.27	3	PLN, CSRP3, MYL3
purine ribonucleotide metabolic process (GO:0009150)	4.16	3	MYH7, MYH6, PRKAG2
regulation of actin cytoskeleton organization (GO:0032956)	4.09	3	ACTN2, TPM1, CAV3
secretion (GO:0046903)	3.38	3	ACTN2, TTN, VCL
adult heart development (GO:0007512)	7.16	3	MYH7, MYH6, TCAP
regulation of transferase activity (GO:0051338)	2.88	3	TTN, CAV3, PRKAG2
muscle hypertrophy (GO:0014896)	6.68	3	TTN, CSRP3, TCAP
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	3	ACTN2, CSRP3, MYH6
regulation of cell motility (GO:2000145)	3.16	3	TPM1, NEXN, VCL
regulation of cation channel activity (GO:2001257)	5.27	3	ACTN2, PLN, JPH2
nucleoside phosphate metabolic process (GO:0006753)	3.71	3	MYH7, MYH6, PRKAG2
regulation of protein metabolic process (GO:0051246)	1.93	3	TTN, CAV3, PRKAG2
cellular nitrogen compound metabolic process (GO:0034641)	1.22	3	MYH7, MYH6, PRKAG2
heart contraction (GO:0060047)	7.02	3	TNNI3, ACTC1, MYL2
muscle structure development (GO:0061061)	4.96	3	CSRP3, CAV3, MYH6
nucleoside monophosphate metabolic process (GO:0009123)	4.54	3	MYH7, MYH6, PRKAG2
purine nucleoside monophosphate metabolic process (GO:0009126)	4.69	3	MYH7, MYH6, PRKAG2
ribonucleotide metabolic process (GO:0009259)	4.11	3	MYH7, MYH6, PRKAG2
nucleobase-containing compound metabolic process (GO:0006139)	1.35	3	MYH7, MYH6, PRKAG2
purine nucleoside metabolic process (GO:0042278)	4.32	3	MYH7, MYH6, PRKAG2
cardiac muscle hypertrophy (GO:0003300)	6.84	3	TTN, CSRP3, TCAP
regulation of kinase activity (GO:0043549)	3.07	3	TTN, CAV3, PRKAG2
regulation of protein modification process (GO:0031399)	2.32	3	TTN, CAV3, PRKAG2
biological adhesion (GO:0022610)	2.81	3	ACTN2, MYBPC3, VCL
cellular aromatic compound metabolic process (GO:0006725)	1.3	3	MYH7, MYH6, PRKAG2
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	3	ACTN2, CSRP3, MYH6
negative regulation of ion transport (GO:0043271)	4.94	3	PLN, ACTN2, CAV3
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	3	MYH7, MYH6, PRKAG2
protein oligomerization (GO:0051259)	3.71	3	PLN, ACTN2, TNNT2
regulation of cellular protein metabolic process (GO:0032268)	1.99	3	TTN, CAV3, PRKAG2
carbohydrate derivative metabolic process (GO:1901135)	3.07	3	MYH7, MYH6, PRKAG2
regulation of RNA metabolic process (GO:0051252)	1.52	3	ACTN2, CSRP3, MYH6
negative regulation of cation transmembrane transport (GO:1904063)	5.65	3	PLN, ACTN2, CAV3
nitrogen compound metabolic process (GO:0006807)	1.13	3	MYH7, MYH6, PRKAG2
cell projection organization (GO:0030030)	3.14	3	ACTN2, TPM1, VCL
positive regulation of cellular metabolic process (GO:0031325)	1.81	3	CSRP3, CAV3, PRKAG2
skeletal muscle thin filament assembly (GO:0030240)	8.12	3	TTN, ACTC1, TCAP
regulation of calcium ion transmembrane transport (GO:1903169)	4.98	3	PLN, CAV3, JPH2
striated muscle tissue development (GO:0014706)	5.23	3	PLN, CSRP3, MYL3
purine-containing compound metabolic process (GO:0072521)	4.0	3	MYH7, MYH6, PRKAG2
regulation of muscle adaptation (GO:0043502)	5.78	3	TNNC1, MYH7, CAV3
multicellular organism development (GO:0007275)	2.54	3	CSRP3, TPM1, MYH6
platelet degranulation (GO:0002576)	5.12	3	ACTN2, TTN, VCL
striated muscle hypertrophy (GO:0014897)	6.78	3	TTN, CSRP3, TCAP
regulation of cell migration (GO:0030334)	3.23	3	TPM1, NEXN, VCL
cellular protein localization (GO:0034613)	3.11	3	CSRP3, CAV3, VCL
regulation of phosphorus metabolic process (GO:0051174)	2.35	3	TTN, CAV3, PRKAG2
nucleotide metabolic process (GO:0009117)	3.73	3	MYH7, MYH6, PRKAG2
nucleoside metabolic process (GO:0009116)	4.12	3	MYH7, MYH6, PRKAG2
cell adhesion (GO:0007155)	2.82	3	ACTN2, MYBPC3, VCL
ribonucleoside metabolic process (GO:0009119)	4.21	3	MYH7, MYH6, PRKAG2
response to oxygen-containing compound (GO:1901700)	2.57	3	PLN, TPM1, ACTC1
regulation of calcium ion transmembrane transporter activity (GO:1901019)	5.49	3	PLN, CAV3, JPH2
regulation of locomotion (GO:0040012)	3.12	3	TPM1, NEXN, VCL
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	3	PLN, CAV3, JPH2
regulation of calcium ion transport (GO:0051924)	4.38	3	PLN, CAV3, JPH2
ribose phosphate metabolic process (GO:0019693)	4.06	3	MYH7, MYH6, PRKAG2
glycosyl compound metabolic process (GO:1901657)	4.04	3	MYH7, MYH6, PRKAG2
regulation of ion homeostasis (GO:2000021)	4.44	3	PLN, CAV3, JPH2
regulation of multicellular organismal development (GO:2000026)	2.31	3	CAV3, MYH6, JPH2
muscle tissue development (GO:0060537)	5.1	3	PLN, CSRP3, MYL3
regulation of protein phosphorylation (GO:0001932)	2.57	3	TTN, CAV3, PRKAG2
regulation of growth (GO:0040008)	3.26	3	CAV3, MYL2, MYH6
regulation of cardiac conduction (GO:1903779)	5.57	2	PLN, TNNI3
protein homooligomerization (GO:0051260)	4.21	2	PLN, ACTN2
regulation of sequestering of calcium ion (GO:0051282)	5.07	2	PLN, JPH2
regulation of calcium-mediated signaling (GO:0050848)	5.41	2	PLN, JPH2
cell surface receptor signaling pathway (GO:0007166)	2.09	2	PLN, MYH6
positive regulation of transmembrane transport (GO:0034764)	4.99	2	ACTN2, JPH2
positive regulation of ion transmembrane transport (GO:0034767)	5.05	2	ACTN2, JPH2
establishment of protein localization to plasma membrane (GO:0090002)	5.2	2	ACTN2, CAV3
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	2	CAV3, PRKAG2
striated muscle myosin thick filament assembly (GO:0071688)	8.63	2	TTN, TCAP
peptidyl-amino acid modification (GO:0018193)	2.98	2	TTN, MYLK2
response to organic substance (GO:0010033)	2.2	2	PLN, ACTC1
regulation of calcium ion transport into cytosol (GO:0010522)	5.23	2	PLN, JPH2
regulation of cell proliferation (GO:0042127)	2.41	2	TPM1, CAV3
regulation of striated muscle tissue development (GO:0016202)	5.09	2	CAV3, JPH2
sarcomerogenesis (GO:0048769)	8.63	2	TTN, TCAP
heart morphogenesis (GO:0003007)	5.84	2	MYBPC3, MYL2
regulation of potassium ion transmembrane transport (GO:1901379)	5.62	2	ACTN2, CAV3
divalent inorganic cation transport (GO:0072511)	4.13	2	PLN, JPH2
regulation of cardiac muscle contraction (GO:0055117)	5.57	2	PLN, CAV3
single organism signaling (GO:0044700)	3.25	2	PLN, MYLK2
negative regulation of phosphorylation (GO:0042326)	3.7	2	CAV3, PRKAG2
transmembrane transport (GO:0055085)	2.72	2	PRKAG2, JPH2
positive regulation of cytosolic calcium ion concentration (GO:0007204)	4.56	2	CAV3, JPH2
regulation of protein localization to cell surface (GO:2000008)	6.43	2	ACTN2, CAV3
negative regulation of protein localization to cell surface (GO:2000009)	7.53	2	ACTN2, CAV3
regulation of cellular component size (GO:0032535)	4.21	2	ACTN2, CAV3
negative regulation of kinase activity (GO:0033673)	4.22	2	CAV3, PRKAG2
positive regulation of receptor activity (GO:2000273)	5.97	2	ACTN2, JPH2
regulation of catabolic process (GO:0009894)	3.52	2	CAV3, PRKAG2
negative regulation of metabolic process (GO:0009892)	1.93	2	CAV3, PRKAG2
regulation of skeletal muscle contraction (GO:0014819)	7.33	2	MYH7, CAV3
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	TPM1, CAV3
negative regulation of protein serine/threonine kinase activity (GO:0071901)	4.92	2	CAV3, PRKAG2
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	2	CAV3, PRKAG2
regulation of apoptotic process (GO:0042981)	2.5	2	ACTN2, ACTC1
cell growth (GO:0016049)	4.83	2	CAV3, VCL
negative regulation of transferase activity (GO:0051348)	3.87	2	CAV3, PRKAG2
regulation of anatomical structure size (GO:0090066)	3.78	2	ACTN2, CAV3
regulation of protein localization (GO:0032880)	2.88	2	ACTN2, CAV3
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	2	ACTN2, PLN
regulation of muscle tissue development (GO:1901861)	5.07	2	CAV3, JPH2
organ morphogenesis (GO:0009887)	3.55	2	MYBPC3, MYL2
lipid metabolic process (GO:0006629)	2.68	2	CAV3, PRKAG2
cation transport (GO:0006812)	3.11	2	PLN, JPH2
regulation of cardiac muscle tissue development (GO:0055024)	5.86	2	CAV3, JPH2
calcium ion transport (GO:0006816)	4.33	2	PLN, JPH2
response to stress (GO:0006950)	1.8	2	TPM1, TCAP
negative regulation of protein modification process (GO:0031400)	3.4	2	CAV3, PRKAG2
positive regulation of protein modification process (GO:0031401)	2.7	2	CAV3, PRKAG2
regulation of transcription, DNA-templated (GO:0006355)	1.56	2	CSRP3, MYH6
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	2	CSRP3, MYH6
negative regulation of cell motility (GO:2000146)	4.36	2	TPM1, VCL
regulation of developmental growth (GO:0048638)	4.04	2	CAV3, MYH6
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	2	CAV3, PRKAG2
negative regulation of cell growth (GO:0030308)	4.58	2	CAV3, MYL2
skeletal muscle tissue development (GO:0007519)	5.65	2	CSRP3, MYL3
regulation of muscle organ development (GO:0048634)	5.07	2	CAV3, JPH2
regulation of cellular protein localization (GO:1903827)	3.43	2	ACTN2, CAV3
embryo development (GO:0009790)	4.2	2	TPM1, MYH6
embryo development ending in birth or egg hatching (GO:0009792)	4.35	2	TPM1, MYH6
signaling (GO:0023052)	3.25	2	PLN, MYLK2
response to calcium ion (GO:0051592)	4.98	2	TTN, TNNT2
negative regulation of growth (GO:0045926)	4.24	2	CAV3, MYL2
negative regulation of cellular protein localization (GO:1903828)	4.82	2	ACTN2, CAV3
negative regulation of protein metabolic process (GO:0051248)	2.82	2	CAV3, PRKAG2
in utero embryonic development (GO:0001701)	4.4	2	TPM1, MYH6
transition between fast and slow fiber (GO:0014883)	7.78	2	TNNC1, MYH7
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	PLN, CAV3
positive regulation of protein metabolic process (GO:0051247)	2.43	2	CAV3, PRKAG2
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	CAV3, PRKAG2
adherens junction organization (GO:0034332)	5.48	2	ACTN2, VCL
chordate embryonic development (GO:0043009)	4.38	2	TPM1, MYH6
regulation of heart growth (GO:0060420)	5.97	2	CAV3, MYH6
negative regulation of cellular metabolic process (GO:0031324)	2.01	2	CAV3, PRKAG2
establishment of protein localization (GO:0045184)	2.53	2	ACTN2, CAV3
regulation of muscle filament sliding speed (GO:0032972)	9.04	2	TNNC1, TNNT2
positive regulation of ion transmembrane transporter activity (GO:0032414)	5.55	2	ACTN2, JPH2
negative regulation of locomotion (GO:0040013)	4.22	2	TPM1, VCL
regulation of vesicle-mediated transport (GO:0060627)	3.63	2	ACTN2, CAV3
positive regulation of ion transport (GO:0043270)	4.36	2	ACTN2, JPH2
negative regulation of cell differentiation (GO:0045596)	3.33	2	CSRP3, CAV3
regulation of cell differentiation (GO:0045595)	2.42	2	CSRP3, CAV3
regulation of cell growth (GO:0001558)	3.75	2	CAV3, MYL2
metal ion transport (GO:0030001)	3.36	2	PLN, JPH2
cell-cell junction organization (GO:0045216)	4.66	2	ACTN2, VCL
cellular lipid metabolic process (GO:0044255)	2.92	2	CAV3, PRKAG2
cell junction assembly (GO:0034329)	4.86	2	ACTN2, VCL
negative regulation of developmental process (GO:0051093)	3.17	2	CSRP3, CAV3
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	2	CAV3, PRKAG2
divalent metal ion transport (GO:0070838)	4.15	2	PLN, JPH2
positive regulation of developmental process (GO:0051094)	2.77	2	CSRP3, CAV3
positive regulation of cation transmembrane transport (GO:1904064)	5.17	2	ACTN2, JPH2
cardiac muscle tissue development (GO:0048738)	6.33	2	PLN, CSRP3
establishment of protein localization to membrane (GO:0090150)	4.14	2	ACTN2, CAV3
myosin filament assembly (GO:0031034)	8.63	2	TTN, TCAP
myosin filament organization (GO:0031033)	8.63	2	TTN, TCAP
adherens junction assembly (GO:0034333)	6.2	2	ACTN2, VCL
cell projection assembly (GO:0030031)	4.19	2	ACTN2, VCL
skeletal muscle myosin thick filament assembly (GO:0030241)	8.63	2	TTN, TCAP
cell junction organization (GO:0034330)	4.51	2	ACTN2, VCL
negative regulation of potassium ion transport (GO:0043267)	6.26	2	ACTN2, CAV3
regulation of potassium ion transport (GO:0043266)	5.31	2	ACTN2, CAV3
cell cycle process (GO:0022402)	2.75	2	TTN, PRKAG2
regulation of muscle cell differentiation (GO:0051147)	4.68	2	CSRP3, CAV3
cellular macromolecular complex assembly (GO:0034622)	3.18	2	TTN, TCAP
positive regulation of muscle cell differentiation (GO:0051149)	5.26	2	CSRP3, CAV3
negative regulation of muscle cell differentiation (GO:0051148)	5.7	2	CSRP3, CAV3
regulation of cell death (GO:0010941)	2.43	2	ACTN2, ACTC1
growth (GO:0040007)	3.8	2	CAV3, VCL
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	2	CSRP3, MYH6
regulation of programmed cell death (GO:0043067)	2.49	2	ACTN2, ACTC1
negative regulation of potassium ion transmembrane transport (GO:1901380)	6.68	2	ACTN2, CAV3
negative regulation of cell migration (GO:0030336)	4.41	2	TPM1, VCL
negative regulation of protein kinase activity (GO:0006469)	4.29	2	CAV3, PRKAG2
negative regulation of phosphate metabolic process (GO:0045936)	3.45	2	CAV3, PRKAG2
regulation of organ growth (GO:0046620)	5.41	2	CAV3, MYH6
positive regulation of cation channel activity (GO:2001259)	6.17	2	ACTN2, JPH2
ion transmembrane transport (GO:0034220)	3.08	2	PRKAG2, JPH2
establishment of localization in cell (GO:0051649)	2.47	2	PRKAG2, JPH2
regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	6.51	2	PLN, JPH2
cellular protein complex assembly (GO:0043623)	3.9	2	TTN, TCAP
positive regulation of transporter activity (GO:0032411)	5.44	2	ACTN2, JPH2
positive regulation of cell differentiation (GO:0045597)	3.01	2	CSRP3, CAV3
negative regulation of cellular component movement (GO:0051271)	4.22	2	TPM1, VCL
negative regulation of calcium ion transport (GO:0051926)	5.84	2	PLN, CAV3
regulation of release of sequestered calcium ion into cytosol (GO:0051279)	5.44	2	PLN, JPH2
regulation of skeletal muscle adaptation (GO:0014733)	7.16	2	TNNC1, MYH7
regulation of potassium ion transmembrane transporter activity (GO:1901016)	6.02	2	ACTN2, CAV3
negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	6.96	2	ACTN2, CAV3
regulation of cellular component biogenesis (GO:0044087)	3.08	2	TPM1, CAV3
negative regulation of protein phosphorylation (GO:0001933)	3.79	2	CAV3, PRKAG2
single-organism cellular localization (GO:1902580)	3.16	2	CAV3, PRKAG2
positive regulation of cellular component biogenesis (GO:0044089)	3.71	2	TPM1, CAV3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
response to abiotic stimulus (GO:0009628)	-	2.8	0.016	ACTN2, TPM1, TNNT2, TCAP, TTN, ACTC1, CSRP3, MYPN, TNNI3, CAV3, VCL, MYH6, MYBPC3, MYL2
regulation of phosphate metabolic process (GO:0019220)	-	2.35	0.011	PLN, TPM1, TNNT2, MYL3, TTN, PRKAG2, TNNI3, TNNC1, CAV3, MYH6, MYBPC3
regulation of intracellular transport (GO:0032386)	-	3.58	0.009	ACTN2, PLN, TPM1, TCAP, TNNC1, MYLK2, CAV3, VCL, MYBPC3, NEXN
cell development (GO:0048468)	-	3.28	0.05	ACTN2, TPM1, TCAP, TTN, NEXN, VCL, CAV3, MYOZ2, MYH6, MYBPC3, MYL2
behavior (GO:0007610)	NEW	3.47	0.012	ACTN2, TPM1, TCAP, ACTC1, VCL, TNNI3, CAV3, MYH6, LDB3, MYBPC3, MYL2
regulation of relaxation of cardiac muscle (GO:1901897)	NEW	7.78	0.031	PLN, TTN
muscle system process (GO:0003012)	-	4.18	0.0	ACTN2, PLN, TPM1, TTN, TCAP, MYH7, TNNC1, ACTC1, CSRP3, MYLK2, TNNI3, CAV3, VCL, MYH6, MYBPC3, MYL2, MYL3
circulatory system process (GO:0003013)	-	4.38	0.021	ACTN2, PLN, TPM1, ACTC1, VCL, TNNI3, CAV3, MYH6, MYL2
heart process (GO:0003015)	-	7.02	0.0	TNNI3, ACTC1, CAV3, MYL2
cellular component organization or biogenesis (GO:0071840)	-	1.22	0.009	ACTN2, PLN, TPM1, TNNT2, TCAP, TTN, ACTC1, CSRP3, PRKAG2, CAV3, VCL, MYH6, LDB3, MYPN, MYBPC3, MYL2
muscle organ development (GO:0007517)	-	4.98	0.0	ACTN2, TNNT2, TCAP, MYH7, MYH6, CAV3, MYPN, MYBPC3
adult heart development (GO:0007512)	-	7.16	0.0	ACTN2, MYH7, TTN, MYH6, TCAP
striated muscle myosin thick filament assembly (GO:0071688)	-	8.63	0.004	TTN, MYBPC3, TCAP
response to mechanical stimulus (GO:0009612)	-	4.41	0.0	ACTN2, TPM1, MYH6, TCAP, TTN, CSRP3, VCL, TNNI3, MYPN
cellular homeostasis (GO:0019725)	-	3.23	0.049	ACTN2, PLN, CSRP3, MYH6, ACTC1, JPH2, TNNI3, CAV3, VCL, MYBPC3
muscle contraction (GO:0006936)	-	4.37	0.0	ACTN2, TPM1, MYH6, MYH7, TTN, TCAP, ACTC1, CSRP3, VCL, TNNI3, CAV3, MYLK2, TNNC1, MYBPC3, MYL2, MYL3
regulation of muscle contraction (GO:0006937)	-	4.75	0.0	ACTN2, PLN, TPM1, TNNT2, MYH6, TNNC1, MYLK2, TNNI3, CAV3, VCL, MYBPC3, MYL2, MYL3
negative regulation of ATPase activity (GO:0032780)	-	7.16	0.002	PLN, TNNI3, TNNT2
positive regulation of ATPase activity (GO:0032781)	-	5.99	0.0	ACTN2, MYBPC3, TNNT2, TPM1, MYL3
sarcomerogenesis (GO:0048769)	-	8.63	0.004	TTN, TCAP
muscle filament sliding (GO:0030049)	-	6.09	0.0	ACTN2, TPM1, TNNT2, TCAP, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, MYL3, MYBPC3, MYL2
actin filament-based movement (GO:0030048)	-	5.54	0.0	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYH6, TNNI3, TNNC1, MYL3, MYBPC3, MYL2
skeletal muscle contraction (GO:0003009)	-	6.33	0.0	ACTN2, TNNC1, MYBPC3, MYL3, TCAP
system process (GO:0003008)	-	2.3	0.0	ACTN2, PLN, TPM1, TCAP, MYH7, TNNC1, ACTC1, CSRP3, MYLK2, TNNI3, TTN, VCL, MYH6, MYBPC3, MYL2, MYL3
single-multicellular organism process (GO:0044707)	-	1.78	0.0	ACTN2, PLN, TPM1, TCAP, MYH7, TTN, ACTC1, CSRP3, MYH6, TNNI3, TNNC1, VCL, MYLK2, MYBPC3, MYL2, MYL3
heart contraction (GO:0060047)	-	7.02	0.0	TNNI3, ACTC1, CAV3, MYL2
negative regulation of protein localization to cell surface (GO:2000009)	-	7.53	0.042	ACTN2, CAV3
muscle tissue morphogenesis (GO:0060415)	-	5.62	0.0	ACTN2, TPM1, TNNT2, TCAP, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, MYLK2, MYPN, MYBPC3, MYL2, MYL3
calcium ion homeostasis (GO:0055074)	-	3.97	0.024	PLN, TNNI3, CSRP3, CAV3, JPH2
positive regulation of ion transmembrane transporter activity (GO:0032414)	-	5.55	0.037	ACTN2, PLN, CAV3, JPH2
regulation of catabolic process (GO:0009894)	-	3.52	0.005	ACTN2, PLN, TPM1, TNNT2, TCAP, MYH7, TNNC1, PRKAG2, TNNI3, CAV3, VCL, MYH6, MYBPC3, MYL3
cellular component assembly (GO:0022607)	-	2.14	0.002	ACTN2, PLN, CSRP3, TCAP, TTN, ACTC1, VCL, CAV3, MYH6, MYBPC3, MYL2
negative regulation of transporter activity (GO:0032410)	-	5.59	0.019	PLN, ACTN2, CAV3
regulation of ion transmembrane transporter activity (GO:0032412)	-	4.55	0.029	ACTN2, PLN, CAV3, JPH2
negative regulation of ion transmembrane transporter activity (GO:0032413)	-	5.74	0.01	PLN, ACTN2, CAV3
regulation of purine nucleotide catabolic process (GO:0033121)	NEW	8.34	0.001	ACTN2, PLN, TPM1, TNNT2, MYL3, MYH7, TNNC1, VCL, TNNI3, CAV3, MYH6, MYBPC3
cellular component movement (GO:0006928)	-	2.61	0.0	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYH6, TNNI3, TNNC1, VCL, MYBPC3, MYL2, MYL3
response to muscle stretch (GO:0035994)	-	6.78	0.0	TTN, CSRP3, TCAP
detection of muscle stretch (GO:0035995)	-	8.34	0.0	TTN, CSRP3, TCAP
cardiac conduction (GO:0061337)	NEW	5.54	0.049	ACTN2, PLN, CAV3
cellular component organization (GO:0016043)	-	1.24	0.008	ACTN2, PLN, TPM1, TNNT2, TCAP, TTN, PRKAG2, ACTC1, CSRP3, MYPN, CAV3, VCL, MYH6, LDB3, MYBPC3, MYL2
regulation of molecular function (GO:0065009)	-	1.78	0.006	ACTN2, PLN, TPM1, TNNT2, MYH6, TTN, JPH2, TNNI3, CAV3, PRKAG2, TNNC1, MYBPC3, MYL3
regulation of biological quality (GO:0065008)	-	1.68	0.001	ACTN2, PLN, TPM1, JPH2, MYL3, MYH7, TTN, CSRP3, VCL, TNNI3, TNNC1, CAV3, MYH6, MYBPC3
anatomical structure formation involved in morphogenesis (GO:0048646)	-	3.01	0.029	ACTN2, TPM1, TNNT2, TCAP, TTN, ACTC1, CSRP3, MYLK2, TNNI3, CAV3, MYH6, LDB3, MYBPC3, MYL2
regulation of catalytic activity (GO:0050790)	-	1.97	0.041	PLN, TPM1, TNNT2, MYL3, TNNC1, TTN, PRKAG2, TNNI3, CAV3, MYH6, MYBPC3
ion transport (GO:0006811)	-	2.66	0.04	ACTN2, PLN, TPM1, TNNT2, TCAP, NEXN, ACTC1, PRKAG2, TNNI3, JPH2, CAV3, MYH6, MYL2
regulation of heart contraction (GO:0008016)	-	4.35	0.0	ACTN2, PLN, TPM1, TNNT2, MYH7, CSRP3, MYH6, CAV3, MYL3, MYBPC3, MYL2
tissue development (GO:0009888)	-	3.27	0.027	ACTN2, PLN, TPM1, TNNT2, MYH7, CSRP3, MYH6, CAV3, MYL3, LDB3, MYBPC3, MYL2
regulation of multicellular organismal process (GO:0051239)	-	1.87	0.0	PLN, TPM1, TNNT2, MYH6, MYH7, TNNC1, CSRP3, MYLK2, TNNI3, CAV3, TTN, JPH2, MYBPC3, MYL2, MYL3
single-organism developmental process (GO:0044767)	-	1.49	0.0	TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, CSRP3, MYL3, TNNI3, MYLK2, VCL, CAV3, CALR3, MYH6, TNNC1, MYBPC3, MYL2, NEXN
detection of stimulus (GO:0051606)	-	3.22	0.002	ACTN2, TPM1, TNNT2, TCAP, TTN, CSRP3, MYH6, TNNI3, CAV3, MYBPC3, NEXN
regulation of transmembrane transporter activity (GO:0022898)	-	4.52	0.033	ACTN2, PLN, CAV3, JPH2
muscle hypertrophy (GO:0014896)	-	6.68	0.002	TTN, CSRP3, MYL2, TCAP
striated muscle hypertrophy (GO:0014897)	-	6.78	0.002	TTN, CSRP3, MYL2, TCAP
skeletal muscle tissue development (GO:0007519)	-	5.65	0.009	MYL3, CSRP3, MYH7, MYL2, TPM1
cellular component assembly involved in morphogenesis (GO:0010927)	-	4.29	0.0	ACTN2, CSRP3, TCAP, TTN, ACTC1, MYH6, LDB3, MYBPC3, MYL2
striated muscle contraction (GO:0006941)	-	5.37	0.0	ACTN2, TPM1, TCAP, MYH7, TTN, ACTC1, CSRP3, MYH6, TNNI3, TNNC1, CAV3, MYLK2, MYBPC3, MYL2, MYL3
regulation of smooth muscle contraction (GO:0006940)	NEW	5.63	0.049	TNNI3, MYBPC3, TPM1, VCL
regulation of striated muscle contraction (GO:0006942)	-	5.38	0.0	ACTN2, PLN, MYL3, CAV3, MYH6, MYBPC3, MYL2
muscle structure development (GO:0061061)	-	4.96	0.0	ACTN2, TNNT2, TCAP, MYH7, MYPN, CAV3, MYH6, MYBPC3
myosin filament organization (GO:0031033)	-	8.63	0.0	TTN, MYBPC3, TPM1, TCAP
anatomical structure morphogenesis (GO:0009653)	-	2.53	0.0	TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYH6, TNNI3, TNNC1, VCL, MYLK2, MYBPC3, MYL2, MYL3
cardiac muscle contraction (GO:0060048)	-	5.88	0.0	TPM1, MYL3, TCAP, TNNC1, ACTC1, CSRP3, MYLK2, TNNI3, CAV3, TTN, MYH6, MYBPC3, MYL2
divalent inorganic cation homeostasis (GO:0072507)	-	3.9	0.032	PLN, TNNI3, CSRP3, CAV3, JPH2
organelle assembly (GO:0070925)	-	3.75	0.002	ACTN2, CSRP3, TCAP, TTN, ACTC1, MYH6, LDB3, MYBPC3, MYL2
cellular divalent inorganic cation homeostasis (GO:0072503)	-	3.96	0.023	ACTN2, PLN, CSRP3, MYH7, JPH2, TNNI3, CAV3
regulation of system process (GO:0044057)	-	3.53	0.0	ACTN2, PLN, TPM1, TNNT2, MYH6, MYH7, TNNC1, CSRP3, MYLK2, TNNI3, CAV3, TTN, VCL, MYBPC3, MYL2, MYL3
cardiac muscle hypertrophy (GO:0003300)	-	6.84	0.002	TTN, CSRP3, TPM1, TCAP
actin-myosin filament sliding (GO:0033275)	-	6.09	0.0	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYH6, TNNI3, TNNC1, MYL3, MYBPC3, MYL2
regulation of nucleotide catabolic process (GO:0030811)	NEW	8.34	0.001	ACTN2, PLN, TPM1, TNNT2, MYL3, MYH7, TNNC1, VCL, TNNI3, CAV3, MYH6, MYBPC3
regulation of the force of heart contraction (GO:0002026)	-	6.4	0.0	ACTN2, PLN, CSRP3, MYH7, MYH6, CAV3, MYL3, MYBPC3
regulation of heart rate (GO:0002027)	-	5.29	0.0	ACTN2, PLN, TPM1, MYH7, MYH6, CAV3, MYBPC3, MYL2
regulation of transporter activity (GO:0032409)	-	4.45	0.045	PLN, ACTN2, CAV3, JPH2
developmental process (GO:0032502)	-	1.36	0.0	PLN, TPM1, TTN, TNNT2, TCAP, MYH7, TNNC1, ACTC1, CSRP3, MYL3, TNNI3, MYLK2, VCL, CAV3, CALR3, MYH6, MYL2, MYBPC3, NEXN
muscle cell development (GO:0055001)	-	5.29	0.0	ACTN2, TPM1, TCAP, TTN, NEXN, MYH6, MYOZ2, CAV3, MYL2
striated muscle cell development (GO:0055002)	-	5.42	0.0	ACTN2, TPM1, TCAP, TTN, MYH6, CAV3, MYOZ2, NEXN, MYL2
multicellular organismal process (GO:0032501)	-	1.45	0.0	ACTN2, PLN, TPM1, TCAP, MYH7, TNNC1, ACTC1, CSRP3, MYLK2, TNNI3, TTN, VCL, MYH6, MYBPC3, MYL2, MYL3
regulation of actin filament-based movement (GO:1903115)	-	6.33	0.0	ACTN2, PLN, TNNC1, MYLK2, MYH6, MYBPC3
heart development (GO:0007507)	-	4.24	0.002	TTN, MYH7, TNNI3, MYH6, TCAP
cardiac muscle tissue morphogenesis (GO:0055008)	-	5.8	0.0	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYH6, TNNI3, MYLK2, MYPN, TNNC1, MYBPC3, MYL2, MYL3
cellular calcium ion homeostasis (GO:0006874)	-	4.01	0.039	ACTN2, PLN, CSRP3, MYH7, JPH2, TNNI3, CAV3
regulation of muscle filament sliding (GO:0032971)	-	8.34	0.0	TNNC1, MYBPC3, MYLK2
regulation of actin filament-based process (GO:0032970)	-	3.97	0.001	ACTN2, PLN, TPM1, TNNC1, ACTC1, VCL, CAV3, MYLK2, MYBPC3, MYL2
regulation of purine nucleotide metabolic process (GO:1900542)	NEW	4.41	0.001	ACTN2, PLN, TPM1, TNNT2, MYL3, MYH7, TNNC1, PRKAG2, TNNI3, CAV3, VCL, MYH6, MYBPC3
sarcomere organization (GO:0045214)	-	6.4	0.0	ACTN2, TPM1, TNNT2, TCAP, TTN, MYPN, MYH6, LDB3, MYBPC3, MYL2
regulation of localization (GO:0032879)	-	1.94	0.012	ACTN2, PLN, TPM1, PRKAG2, TNNC1, VCL, MYLK2, CAV3, JPH2, MYBPC3, NEXN
regulation of calcium ion transmembrane transporter activity (GO:1901019)	-	5.49	0.029	PLN, CAV3, JPH2
cardiac muscle fiber development (GO:0048739)	-	7.65	0.0	TNNI3, TTN, NEXN, TCAP, MYH6
regulation of cellular catabolic process (GO:0031329)	NEW	3.83	0.0	ACTN2, PLN, TPM1, TNNT2, MYL3, TCAP, TNNC1, PRKAG2, TNNI3, CAV3, VCL, MYH6, MYBPC3
myosin filament assembly (GO:0031034)	-	8.63	0.0	TTN, MYBPC3, TPM1, TCAP
cardiac muscle cell development (GO:0055013)	-	6.4	0.0	TCAP, TTN, CAV3, TNNI3, MYH6, NEXN
actomyosin structure organization (GO:0031032)	-	5.4	0.0	ACTN2, TPM1, TNNT2, TCAP, TNNC1, ACTC1, CSRP3, MYH6, TTN, MYPN, LDB3, MYBPC3, MYL2
regulation of cellular localization (GO:0060341)	-	3.03	0.0	ACTN2, PLN, TPM1, TNNT2, TCAP, TNNC1, ACTC1, CSRP3, VCL, MYLK2, CAV3, MYH6, LDB3, MYPN, MYL2, MYBPC3, NEXN
ventricular cardiac muscle tissue morphogenesis (GO:0055010)	-	6.07	0.0	TPM1, TNNT2, MYH7, TNNC1, MYL3, TNNI3, MYH6, MYBPC3, MYL2
skeletal muscle myosin thick filament assembly (GO:0030241)	-	8.63	0.004	TTN, MYBPC3, TCAP
skeletal muscle thin filament assembly (GO:0030240)	-	8.12	0.0	TTN, ACTC1, TCAP
actin cytoskeleton organization (GO:0030036)	-	4.1	0.0	ACTN2, TPM1, TNNT2, TCAP, TNNC1, ACTC1, CSRP3, MYPN, TTN, VCL, MYH6, LDB3, MYBPC3, MYL2
regulation of calcium ion transmembrane transport (GO:1903169)	-	4.98	0.029	PLN, CAV3, JPH2
striated muscle tissue development (GO:0014706)	-	5.23	0.004	PLN, CSRP3, MYH7, TPM1, MYL3, MYL2
cardiac myofibril assembly (GO:0055003)	-	7.02	0.0	CSRP3, TCAP, TTN, ACTC1, TPM1, MYL2
regulation of ATPase activity (GO:0043462)	-	5.59	0.0	PLN, TPM1, TNNT2, TNNC1, MYH6, TNNI3, MYL3, MYBPC3
cardiac cell development (GO:0055006)	-	6.33	0.0	TCAP, TTN, CAV3, TNNI3, MYH6, NEXN
detection of mechanical stimulus (GO:0050982)	-	5.94	0.0	ACTN2, CSRP3, TCAP, TTN, MYH6, TNNI3
tissue morphogenesis (GO:0048729)	-	3.87	0.0	ACTN2, TPM1, TNNT2, TCAP, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, VCL, MYLK2, MYPN, MYBPC3, MYL2, MYL3
atrial cardiac muscle tissue morphogenesis (GO:0055009)	NEW	8.12	0.022	TNNT2, MYH6
detection of external stimulus (GO:0009581)	-	4.98	0.0	ACTN2, TPM1, TNNT2, TCAP, TTN, CSRP3, MYH6, TNNI3, CAV3, MYBPC3
detection of abiotic stimulus (GO:0009582)	-	4.96	0.0	ACTN2, TPM1, TNNT2, TCAP, TTN, CSRP3, MYH6, TNNI3, CAV3, MYBPC3
negative regulation of muscle contraction (GO:0045932)	NEW	6.68	0.001	PLN, MYBPC3, MYH6, VCL
actin filament-based process (GO:0030029)	-	3.94	0.0	ACTN2, TPM1, TNNT2, TCAP, MYH7, TNNC1, ACTC1, CSRP3, MYH6, TNNI3, TTN, VCL, LDB3, MYPN, MYBPC3, MYL2, MYL3
myofibril assembly (GO:0030239)	-	6.43	0.0	CSRP3, TCAP, TTN, ACTC1, MYH6, MYBPC3, MYL2
muscle fiber development (GO:0048747)	-	5.8	0.0	ACTN2, TCAP, TTN, MYH6, CAV3, MYOZ2, NEXN, MYL2
regulation of phosphorus metabolic process (GO:0051174)	-	2.35	0.012	PLN, TPM1, TNNT2, MYL3, TTN, PRKAG2, TNNI3, TNNC1, CAV3, MYH6, MYBPC3
single-organism cellular process (GO:0044763)	-	0.65	0.001	TPM1, TCAP, VCL, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, PRKAG2, TNNI3, MYLK2, JPH2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
regulation of muscle system process (GO:0090257)	-	4.51	0.0	ACTN2, PLN, TPM1, TNNT2, MYH6, TTN, MYLK2, TNNI3, CAV3, VCL, TNNC1, MYBPC3, MYL2, MYL3
regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	-	6.51	0.022	PLN, CAV3, JPH2
regulation of nucleoside metabolic process (GO:0009118)	NEW	5.82	0.0	ACTN2, PLN, TPM1, TNNT2, MYH6, MYH7, TNNC1, VCL, TNNI3, CAV3, PRKAG2, MYBPC3, MYL3
cellular protein complex assembly (GO:0043623)	-	3.9	0.008	ACTN2, TPM1, TCAP, TTN, ACTC1, TNNI3, MYBPC3, MYL2
organelle organization (GO:0006996)	-	2.02	0.001	TPM1, TNNT2, TCAP, TTN, ACTC1, CSRP3, MYPN, CAV3, MYH6, LDB3, MYBPC3, MYL2
actin filament organization (GO:0007015)	-	4.54	0.0	ACTN2, TPM1, TCAP, MYH7, TTN, ACTC1, CSRP3, VCL, CAV3, MYPN, MYBPC3
regulation of cellular component movement (GO:0051270)	-	3.08	0.0	ACTN2, PLN, TPM1, TNNT2, MYL2, TNNC1, ACTC1, CSRP3, VCL, TNNI3, MYLK2, LDB3, MYBPC3, NEXN
cytoskeleton organization (GO:0007010)	-	3.22	0.0	ACTN2, TPM1, TNNT2, TCAP, TTN, ACTC1, CSRP3, PRKAG2, CAV3, VCL, MYH6, LDB3, TNNC1, MYPN, MYBPC3, MYL2
negative regulation of potassium ion transmembrane transporter activity (GO:1901017)	-	6.96	0.031	ACTN2, CAV3
single-organism organelle organization (GO:1902589)	-	2.68	0.0	TPM1, TNNT2, TCAP, TTN, ACTC1, CSRP3, MYH6, CAV3, MYPN, LDB3, MYBPC3, MYL2
muscle tissue development (GO:0060537)	-	5.1	0.0	ACTN2, PLN, TPM1, MYH7, CSRP3, MYL3, MYL2
regulation of nucleotide metabolic process (GO:0006140)	NEW	4.38	0.001	ACTN2, PLN, TPM1, TNNT2, MYH6, MYH7, TNNC1, VCL, TNNI3, CAV3, PRKAG2, MYBPC3, MYL3
actin-mediated cell contraction (GO:0070252)	-	5.88	0.0	ACTN2, TPM1, TNNT2, TCAP, MYH7, TTN, ACTC1, MYH6, TNNI3, TNNC1, MYL3, MYBPC3, MYL2

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	25	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, JPH2, TNNI3, MYLK2, PRKAG2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
cytoplasmic part (GO:0044444)	0.82	25	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, JPH2, TNNI3, MYLK2, PRKAG2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
cell part (GO:0044464)	0.11	25	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, PLN, TNNT2, MYH6, MYPN, CALR3, MYH7, ACTC1, JPH2, TNNI3, MYLK2, PRKAG2, MYBPC3, NEXN, ACTN2, CSRP3, TTN, MYL3, TNNC1, LDB3
organelle part (GO:0044422)	0.79	25	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, PLN, TNNT2, MYH6, MYPN, CALR3, MYH7, ACTC1, PRKAG2, TNNI3, MYLK2, JPH2, MYBPC3, NEXN, ACTN2, CSRP3, TTN, MYL3, TNNC1, LDB3
contractile fiber part (GO:0044449)	4.53	22	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, TNNT2, MYL3, MYPN, MYH7, ACTC1, JPH2, TNNI3, MYLK2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
intracellular organelle (GO:0043229)	0.51	21	ACTN2, PLN, TPM1, JPH2, TNNT2, MYH7, TNNC1, TTN, ACTC1, CSRP3, MYH6, TNNI3, MYLK2, MYOZ2, CAV3, CALR3, VCL, LDB3, MYL2, MYPN, NEXN
organelle (GO:0043226)	0.4	21	ACTN2, PLN, TPM1, TTN, JPH2, MYH6, MYH7, TNNC1, ACTC1, CSRP3, MYPN, TNNI3, MYLK2, MYOZ2, CAV3, CALR3, VCL, LDB3, TNNT2, MYL2, NEXN
intracellular organelle part (GO:0044446)	0.81	18	ACTN2, PLN, TPM1, TNNT2, MYH7, TTN, PRKAG2, ACTC1, CALR3, MYH6, TNNI3, JPH2, VCL, CAV3, MYL3, TNNC1, MYBPC3, MYL2
cytoplasm (GO:0005737)	1.01	17	ACTN2, CSRP3, TPM1, TCAP, MYH7, TTN, ACTC1, MYOZ2, MYLK2, TNNI3, CAV3, VCL, MYH6, LDB3, MYL2, MYPN, NEXN
cytosol (GO:0005829)	1.68	16	ACTN2, TPM1, TNNT2, MYL3, TCAP, TNNC1, ACTC1, PRKAG2, TTN, VCL, TNNI3, JPH2, CAV3, MYH6, MYBPC3, MYL2
protein complex (GO:0043234)	1.51	15	PLN, TPM1, JPH2, TNNT2, MYL3, MYH7, TTN, PRKAG2, TNNI3, TNNC1, VCL, CAV3, MYH6, MYBPC3, MYL2
non-membrane-bounded organelle (GO:0043228)	1.76	15	ACTN2, TPM1, TNNT2, MYH7, TTN, ACTC1, CSRP3, MYH6, TNNI3, TNNC1, MYOZ2, NEXN, LDB3, VCL, MYL2
macromolecular complex (GO:0032991)	1.35	15	PLN, TPM1, JPH2, TNNT2, MYL3, MYH7, TTN, PRKAG2, VCL, TNNI3, TNNC1, CAV3, MYH6, MYBPC3, MYL2
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	15	ACTN2, TPM1, NEXN, TNNT2, MYH7, TTN, ACTC1, CSRP3, VCL, TNNI3, TNNC1, MYOZ2, MYH6, LDB3, MYL2
sarcomere (GO:0030017)	5.95	14	ACTN2, TPM1, TNNT2, TCAP, MYH7, ACTC1, MYH6, TNNI3, MYOZ2, MYLK2, MYPN, MYBPC3, MYL2, MYL3
cytoskeletal part (GO:0044430)	2.49	13	ACTN2, TPM1, TNNT2, MYL3, MYH7, TNNC1, ACTC1, MYH6, TNNI3, TTN, VCL, MYBPC3, MYL2
membrane-bounded organelle (GO:0043227)	0.47	12	ACTN2, PLN, CSRP3, TTN, ACTC1, CALR3, JPH2, MYLK2, VCL, CAV3, MYPN, TNNC1
Z disc (GO:0030018)	5.11	12	ACTN2, CSRP3, TCAP, MYH7, TTN, MYPN, JPH2, CAV3, MYOZ2, MYH6, LDB3, NEXN
cytoskeleton (GO:0005856)	2.55	10	ACTN2, TPM1, TNNC1, ACTC1, CSRP3, VCL, MYOZ2, NEXN, LDB3, MYL2
intracellular membrane-bounded organelle (GO:0043231)	0.6	9	PLN, CSRP3, TNNC1, CALR3, MYPN, MYLK2, TTN, CAV3, JPH2
contractile fiber (GO:0043292)	5.81	7	TPM1, TNNT2, MYH7, TNNC1, MYH6, TNNI3, MYL2
membrane (GO:0016020)	0.68	7	ACTN2, PLN, TPM1, ACTC1, JPH2, CAV3, VCL
myofibril (GO:0030016)	6.14	6	TPM1, TNNT2, MYH7, MYH6, TNNI3, MYL2
myosin complex (GO:0016459)	5.55	6	MYH7, TTN, MYH6, MYL3, MYBPC3, MYL2
vesicle (GO:0031982)	1.64	6	ACTN2, PLN, TTN, ACTC1, CAV3, VCL
I band (GO:0031674)	6.67	5	TTN, ACTC1, MYPN, TCAP, MYL3
muscle myosin complex (GO:0005859)	6.86	5	MYH7, TTN, MYBPC3, MYL3, MYH6
myosin II complex (GO:0016460)	6.54	5	MYH7, TTN, MYBPC3, MYL3, MYH6
membrane part (GO:0044425)	0.95	5	PLN, CAV3, TPM1, VCL, JPH2
extracellular region part (GO:0044421)	1.57	5	ACTN2, TTN, ACTC1, VCL, PRKAG2
cell junction (GO:0030054)	2.75	5	ACTN2, CAV3, ACTC1, VCL, NEXN
focal adhesion (GO:0005925)	3.83	4	ACTN2, ACTC1, NEXN, VCL
extracellular organelle (GO:0043230)	1.89	4	ACTN2, TTN, ACTC1, VCL
actin cytoskeleton (GO:0015629)	4.39	4	TNNC1, MYOZ2, VCL, MYL2
extracellular exosome (GO:0070062)	1.89	4	TTN, ACTN2, ACTC1, VCL
integral component of membrane (GO:0016021)	1.14	4	PLN, TPM1, CAV3, JPH2
anchoring junction (GO:0070161)	3.61	4	ACTN2, ACTC1, NEXN, VCL
extracellular vesicle (GO:1903561)	1.89	4	ACTN2, TTN, ACTC1, VCL
membrane-bounded vesicle (GO:0031988)	1.71	4	ACTN2, TTN, ACTC1, VCL
adherens junction (GO:0005912)	3.66	4	ACTN2, ACTC1, NEXN, VCL
plasma membrane (GO:0005886)	1.39	4	ACTN2, CAV3, VCL, JPH2
cell-substrate adherens junction (GO:0005924)	3.83	4	ACTN2, ACTC1, NEXN, VCL
cell projection (GO:0042995)	2.47	4	ACTN2, TPM1, ACTC1, LDB3
endoplasmic reticulum (GO:0005783)	2.56	4	PLN, CALR3, CAV3, JPH2
nucleus (GO:0005634)	1.07	4	TTN, CSRP3, MYPN, MYLK2
intrinsic component of membrane (GO:0031224)	1.13	4	PLN, TPM1, CAV3, JPH2
cell-substrate junction (GO:0030055)	3.82	4	ACTN2, ACTC1, NEXN, VCL
actin filament bundle (GO:0032432)	5.74	3	TPM1, MYH7, MYH6
myofilament (GO:0036379)	7.16	3	TTN, MYBPC3, TNNT2
myosin filament (GO:0032982)	6.71	3	MYBPC3, MYH7, MYH6
organelle membrane (GO:0031090)	1.97	3	PLN, CAV3, JPH2
stress fiber (GO:0001725)	5.81	3	TPM1, MYH7, MYH6
bounding membrane of organelle (GO:0098588)	2.39	3	PLN, CAV3, JPH2
A band (GO:0031672)	7.09	3	MYBPC3, MYL3, MYL2
contractile actin filament bundle (GO:0097517)	5.81	3	TPM1, MYH7, MYH6
endoplasmic reticulum part (GO:0044432)	2.73	3	PLN, CALR3, JPH2
extracellular region (GO:0005576)	2.18	3	ACTN2, TTN, VCL
nuclear part (GO:0044428)	1.55	3	TNNC1, TTN, PRKAG2
troponin complex (GO:0005861)	7.72	3	TNNI3, TNNC1, TNNT2
actomyosin (GO:0042641)	5.66	3	TPM1, MYH7, MYH6
plasma membrane region (GO:0098590)	2.97	2	TPM1, CAV3
membrane raft (GO:0045121)	4.18	2	CAV3, VCL
supramolecular fiber (GO:0099512)	3.31	2	ACTN2, ACTC1
polymeric cytoskeletal fiber (GO:0099513)	3.31	2	ACTN2, ACTC1
membrane-enclosed lumen (GO:0031974)	3.05	2	ACTN2, CALR3
endoplasmic reticulum membrane (GO:0005789)	2.95	2	PLN, JPH2
filopodium (GO:0030175)	5.48	2	ACTN2, ACTC1
nucleoplasm (GO:0005654)	1.89	2	TNNC1, PRKAG2
extracellular space (GO:0005615)	2.63	2	ACTC1, PRKAG2
membrane protein complex (GO:0098796)	2.84	2	PLN, CAV3
mitochondrion (GO:0005739)	2.42	2	PLN, TNNC1
sarcoplasmic reticulum membrane (GO:0033017)	6.14	2	PLN, JPH2
perinuclear region of cytoplasm (GO:0048471)	3.35	2	PLN, LDB3
plasma membrane part (GO:0044459)	1.95	2	TPM1, CAV3
catalytic complex (GO:1902494)	2.9	2	PLN, PRKAG2
pseudopodium (GO:0031143)	6.97	2	ACTN2, LDB3
membrane region (GO:0098589)	3.95	2	CAV3, VCL
actin filament (GO:0005884)	5.81	2	ACTN2, ACTC1
cell-cell junction (GO:0005911)	3.85	2	CAV3, VCL
striated muscle thin filament (GO:0005865)	7.4	2	TTN, TNNT2
organelle lumen (GO:0043233)	3.05	2	ACTN2, CALR3
cortical cytoskeleton (GO:0030863)	5.58	2	ACTN2, VCL
cell projection part (GO:0044463)	2.97	2	ACTN2, TPM1
cortical actin cytoskeleton (GO:0030864)	6.11	2	ACTN2, VCL
intracellular organelle lumen (GO:0070013)	3.05	2	ACTN2, CALR3
sarcoplasmic reticulum (GO:0016529)	5.81	2	PLN, JPH2
actin-based cell projection (GO:0098858)	4.83	2	ACTN2, ACTC1
membrane microdomain (GO:0098857)	4.17	2	CAV3, VCL
cell cortex part (GO:0044448)	5.01	2	ACTN2, VCL

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
actin filament bundle (GO:0032432)	-	5.74	0.0	MYH7, TPM1, ACTC1, MYH6, MYPN
actin cytoskeleton (GO:0015629)	-	4.39	0.016	ACTN2, TPM1, TNNC1, CSRP3, VCL, MYOZ2
myofibril (GO:0030016)	-	6.14	0.0	ACTN2, CAV3, MYBPC3, MYH6, MYL2
sarcomere (GO:0030017)	-	5.95	0.0	ACTN2, TPM1, TNNT2, MYL3, MYH7, ACTC1, MYLK2, TNNI3, MYOZ2, MYH6, VCL, MYBPC3, MYL2
non-membrane-bounded organelle (GO:0043228)	-	1.76	0.014	ACTN2, TPM1, TNNC1, NEXN, CSRP3, VCL, TTN, MYOZ2, MYH6, LDB3, MYL2
cytoskeletal part (GO:0044430)	-	2.49	0.0	ACTN2, TPM1, TNNT2, MYL3, MYH7, TTN, PRKAG2, ACTC1, CSRP3, MYPN, TNNI3, CAV3, VCL, MYH6, TNNC1, MYBPC3, MYL2
cell-substrate adherens junction (GO:0005924)	-	3.83	0.001	ACTN2, TPM1, MYH7, TNNC1, ACTC1, VCL, CAV3, MYH6, LDB3, NEXN
focal adhesion (GO:0005925)	-	3.83	0.001	ACTN2, TPM1, MYH7, TNNC1, ACTC1, VCL, CAV3, MYH6, LDB3, NEXN
Z disc (GO:0030018)	-	5.11	0.0	ACTN2, CSRP3, TCAP, MYH7, TTN, ACTC1, JPH2, CAV3, MYOZ2, MYH6, LDB3, MYPN, MYBPC3, NEXN
cell-substrate junction (GO:0030055)	-	3.82	0.001	ACTN2, TPM1, MYH7, TNNC1, ACTC1, VCL, CAV3, MYH6, LDB3, NEXN
cytoskeleton (GO:0005856)	-	2.55	0.0	ACTN2, TPM1, NEXN, TCAP, TNNC1, ACTC1, CSRP3, VCL, TNNI3, CAV3, MYOZ2, MYH6, LDB3, MYL2
stress fiber (GO:0001725)	-	5.81	0.004	TPM1, ACTC1, MYH7, MYPN, MYH6
myosin filament (GO:0032982)	-	6.71	0.001	MYBPC3, MYH7, MYH6
A band (GO:0031672)	-	7.09	0.0	MYBPC3, CSRP3, MYL2, MYL3
I band (GO:0031674)	-	6.67	0.0	ACTN2, TPM1, TCAP, TTN, ACTC1, MYPN, MYL3
muscle myosin complex (GO:0005859)	-	6.86	0.0	MYH7, MYBPC3, MYL3, MYH6
pseudopodium (GO:0031143)	-	6.97	0.022	ACTN2, LDB3
myosin complex (GO:0016459)	-	5.55	0.0	ACTN2, MYH7, MYH6, MYL3, MYBPC3, MYL2
cell junction (GO:0030054)	-	2.75	0.045	ACTN2, TPM1, MYH7, TNNC1, ACTC1, VCL, CAV3, MYH6, LDB3, MYPN, MYBPC3, NEXN
myosin II complex (GO:0016460)	-	6.54	0.0	MYBPC3, MYH7, MYH6, MYL3
actomyosin (GO:0042641)	-	5.66	0.0	TPM1, ACTC1, MYH7, MYPN, MYH6
myofilament (GO:0036379)	-	7.16	0.0	TTN, MYBPC3, TNNT2
apical plasma membrane (GO:0016324)	NEW	4.13	0.035	ACTN2, PLN, CSRP3, VCL, CAV3, MYH6, MYBPC3
anchoring junction (GO:0070161)	-	3.61	0.003	ACTN2, TPM1, MYH7, TNNC1, ACTC1, VCL, CAV3, MYH6, LDB3, NEXN
intracellular part (GO:0044424)	-	0.28	0.032	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, PRKAG2, TNNI3, MYLK2, JPH2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
cell-cell adherens junction (GO:0005913)	NEW	5.81	0.002	ACTN2, ACTC1, CAV3, VCL
adherens junction (GO:0005912)	-	3.66	0.0	ACTN2, TPM1, MYH7, TNNC1, ACTC1, VCL, CAV3, MYH6, LDB3, NEXN
striated muscle thin filament (GO:0005865)	-	7.4	0.021	TTN, TNNT2
troponin complex (GO:0005861)	-	7.72	0.0	TNNI3, TNNC1, TNNT2
protein complex (GO:0043234)	-	1.51	0.002	TPM1, TCAP, VCL, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, PRKAG2, TNNI3, JPH2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, LDB3
macromolecular complex (GO:0032991)	-	1.35	0.012	TPM1, TCAP, VCL, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, PRKAG2, TNNI3, JPH2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, LDB3
intracellular non-membrane-bounded organelle (GO:0043232)	-	1.76	0.014	ACTN2, TPM1, TNNC1, NEXN, CSRP3, VCL, TTN, MYOZ2, MYH6, LDB3, MYL2
cytosol (GO:0005829)	-	1.68	0.0	ACTN2, TPM1, TNNT2, MYL3, TCAP, TTN, ACTC1, MYH6, TNNI3, TNNC1, VCL, PRKAG2, MYBPC3, MYL2
cytoplasmic part (GO:0044444)	-	0.82	0.0	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, PLN, TNNT2, MYL3, MYPN, CALR3, MYH7, ACTC1, PRKAG2, TNNI3, MYLK2, JPH2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3
sarcoplasmic reticulum (GO:0016529)	-	5.81	0.016	PLN, ACTC1, CAV3
contractile fiber (GO:0043292)	-	5.81	0.0	ACTN2, TPM1, TNNC1, MYH6, CAV3, MYBPC3, MYL2
organelle part (GO:0044422)	-	0.79	0.0	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, PLN, TNNT2, MYH6, MYPN, CALR3, MYH7, ACTC1, JPH2, TNNI3, MYLK2, PRKAG2, MYBPC3, NEXN, ACTN2, CSRP3, TTN, MYL3, TNNC1, LDB3
contractile fiber part (GO:0044449)	-	4.53	0.0	TPM1, TCAP, VCL, MYOZ2, CAV3, MYL2, TNNT2, MYL3, MYPN, MYH7, ACTC1, JPH2, TNNI3, MYLK2, MYBPC3, NEXN, ACTN2, CSRP3, TNNC1, MYH6, TTN, LDB3