Disease table of INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED OMIM ID: PS610799

Gene-disease associations table

GeneAssociated with INVASIVE PNEUMOCOCCAL DISEASE, RECURRENT ISOLATED inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IKBKGClinVar, OMIM, HUMSAVARHGNC linkXq286300301, 300636, 308300, PS610799, 300291, 300584
IRAK4ClinVar, OMIMHGNC link12q122PS610799, 607676
TIRAPOMIMHGNC link11q24.24611162, PS610799, 607948, 614382

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
IKBKGIRAK4Yes5MYD88, SASH1, IRAK1, TRAF6, IKBKG
IKBKGTIRAPNo9IRAK4, IRAK1, MAP3K7, TRAF6, RPTOR, NTMT1, TAB2, MYD88, TAB1
IRAK4TIRAPYes6IRAK2, IRAK1, TIRAP, TRAF6, MYD88, TLR4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
IRAK4TIRAPyes, they interactIRAK4 phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
NF-kappa B signaling pathwayhsa040646.213TIRAP, IKBKG, IRAK4
Toll-like receptor signaling pathwayhsa046206.03TIRAP, IKBKG, IRAK4
Pertussishsa051336.462TIRAP, IRAK4
Toxoplasmosishsa051455.712IKBKG, IRAK4
Chagas disease (American trypanosomiasis)hsa051425.992IKBKG, IRAK4
Tuberculosishsa051525.172TIRAP, IRAK4
Apoptosishsa042106.232IKBKG, IRAK4
Hepatitis Bhsa051615.522TIRAP, IKBKG

NET-GE enrichment

Term New enriched termICP valueGenes
Pertussis (hsa05133) -6.460.021TIRAP, IKBKG, IRAK4
Infectious diseases: ParasiticNEW4.460.046TIRAP, IKBKG, IRAK4
Infectious diseases: BacterialNEW3.760.022TIRAP, IKBKG, IRAK4
Tuberculosis (hsa05152) -5.170.01TIRAP, IKBKG, IRAK4
Toll-like receptor signaling pathway (hsa04620) -6.00.001TIRAP, IKBKG, IRAK4
Chagas disease (American trypanosomiasis) (hsa05142) -5.990.04IKBKG, IRAK4
Toxoplasmosis (hsa05145) -5.710.002TIRAP, IKBKG, IRAK4
Apoptosis (hsa04210) -6.230.029IKBKG, IRAK4
NF-kappa B signaling pathway (hsa04064) -6.210.0TIRAP, IKBKG, IRAK4
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.563TIRAP, IKBKG, IRAK4
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.113TIRAP, IKBKG, IRAK4
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.513TIRAP, IKBKG, IRAK4
Innate Immune SystemR-HSA-1682493.173TIRAP, IKBKG, IRAK4
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.513TIRAP, IKBKG, IRAK4
Immune SystemR-HSA-1682562.373TIRAP, IKBKG, IRAK4
Toll-Like Receptors CascadesR-HSA-1688985.913TIRAP, IKBKG, IRAK4
Diseases associated with the TLR signaling cascadeR-HSA-56023588.343TIRAP, IKBKG, IRAK4
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.563TIRAP, IKBKG, IRAK4
Diseases of Immune SystemR-HSA-52602718.343TIRAP, IKBKG, IRAK4
Activated TLR4 signallingR-HSA-1660546.273TIRAP, IKBKG, IRAK4
DiseaseR-HSA-16436853.333TIRAP, IKBKG, IRAK4
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.732IKBKG, IRAK4
Signaling by InterleukinsR-HSA-4491474.712IKBKG, IRAK4
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.722IKBKG, IRAK4
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.682IKBKG, IRAK4
MyD88 cascade initiated on plasma membraneR-HSA-9758716.732IKBKG, IRAK4
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.732IKBKG, IRAK4
Cytokine Signaling in Immune systemR-HSA-12802153.742IKBKG, IRAK4
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.682IKBKG, IRAK4
MyD88 deficiency (TLR2/4)R-HSA-56024989.522TIRAP, IRAK4
IRAK4 deficiency (TLR2/4)R-HSA-56030419.522TIRAP, IRAK4
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.622IKBKG, IRAK4
Interleukin-1 signalingR-HSA-4466527.522IKBKG, IRAK4

NET-GE enrichment

Term New enriched termICP valueGenes
Toll Like Receptor TLR6:TLR2 Cascade (R-HSA-168188) -6.560.0TIRAP, IKBKG, IRAK4
Toll Like Receptor 7/8 (TLR7/8) Cascade (R-HSA-168181) -6.680.017IKBKG, IRAK4
Toll Like Receptor 10 (TLR10) Cascade (R-HSA-168142) -6.730.015IKBKG, IRAK4
MyD88 dependent cascade initiated on endosome (R-HSA-975155) -6.680.017IKBKG, IRAK4
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (R-HSA-975138) -6.720.016IKBKG, IRAK4
Toll Like Receptor 2 (TLR2) Cascade (R-HSA-181438) -6.510.0TIRAP, IKBKG, IRAK4
Toll Like Receptor 4 (TLR4) Cascade (R-HSA-166016) -6.110.001TIRAP, IKBKG, IRAK4
Toll Like Receptor TLR1:TLR2 Cascade (R-HSA-168179) -6.510.0TIRAP, IKBKG, IRAK4
MyD88 cascade initiated on plasma membrane (R-HSA-975871) -6.730.015IKBKG, IRAK4
Toll-Like Receptors Cascades (R-HSA-168898) -5.910.0TIRAP, IKBKG, IRAK4
Diseases of Immune System (R-HSA-5260271) -8.340.0TIRAP, IKBKG, IRAK4
Diseases associated with the TLR signaling cascade (R-HSA-5602358) -8.340.0TIRAP, IKBKG, IRAK4
Toll Like Receptor 9 (TLR9) Cascade (R-HSA-168138) -6.620.018IKBKG, IRAK4
MyD88:Mal cascade initiated on plasma membrane (R-HSA-166058) -6.560.0TIRAP, IKBKG, IRAK4
MyD88 deficiency (TLR2/4) (R-HSA-5602498) -9.520.0TIRAP, IRAK4
IRAK4 deficiency (TLR2/4) (R-HSA-5603041) -9.520.0TIRAP, IRAK4
Activated TLR4 signalling (R-HSA-166054) -6.270.0TIRAP, IKBKG, IRAK4
Interleukin-1 signaling (R-HSA-446652) -7.520.005IKBKG, IRAK4
Toll Like Receptor 5 (TLR5) Cascade (R-HSA-168176) -6.730.015IKBKG, IRAK4
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
receptor binding (GO:0005102) 2.433TIRAP, IKBKG, IRAK4
binding (GO:0005488) 0.183TIRAP, IKBKG, IRAK4
protein binding (GO:0005515) 0.463TIRAP, IKBKG, IRAK4
cation binding (GO:0043169) 1.42IKBKG, IRAK4
protein heterodimerization activity (GO:0046982) 3.642TIRAP, IKBKG
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772IKBKG, IRAK4
kinase activity (GO:0016301) 2.932IKBKG, IRAK4
enzyme binding (GO:0019899) 2.272TIRAP, IKBKG
ion binding (GO:0043167) 1.362IKBKG, IRAK4
catalytic activity (GO:0003824) 1.052IKBKG, IRAK4
transferase activity (GO:0016740) 1.952IKBKG, IRAK4
protein dimerization activity (GO:0046983) 2.722TIRAP, IKBKG
metal ion binding (GO:0046872) 1.412IKBKG, IRAK4
identical protein binding (GO:0042802) 2.632TIRAP, IKBKG
protein homodimerization activity (GO:0042803) 3.162TIRAP, IKBKG

NET-GE enrichment

Term New enriched termICP valueGenes
cytokine receptor binding (GO:0005126) NEW4.140.007TIRAP, IKBKG, IRAK4
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
positive regulation of response to stimulus (GO:0048584) 2.183TIRAP, IKBKG, IRAK4
regulation of response to stimulus (GO:0048583) 1.543TIRAP, IKBKG, IRAK4
positive regulation of defense response (GO:0031349) 3.833TIRAP, IKBKG, IRAK4
signal transduction (GO:0007165) 1.283TIRAP, IKBKG, IRAK4
cell surface receptor signaling pathway (GO:0007166) 2.093TIRAP, IKBKG, IRAK4
regulation of signaling (GO:0023051) 1.723TIRAP, IKBKG, IRAK4
positive regulation of cell communication (GO:0010647) 2.413TIRAP, IKBKG, IRAK4
regulation of cell communication (GO:0010646) 1.733TIRAP, IKBKG, IRAK4
regulation of biological process (GO:0050789) 0.453TIRAP, IKBKG, IRAK4
single-organism process (GO:0044699) 0.483TIRAP, IKBKG, IRAK4
cellular response to stimulus (GO:0051716) 1.973TIRAP, IKBKG, IRAK4
immune response-regulating signaling pathway (GO:0002764) 3.723TIRAP, IKBKG, IRAK4
regulation of signal transduction (GO:0009966) 1.843TIRAP, IKBKG, IRAK4
positive regulation of signal transduction (GO:0009967) 2.53TIRAP, IKBKG, IRAK4
positive regulation of immune system process (GO:0002684) 2.963TIRAP, IKBKG, IRAK4
regulation of immune system process (GO:0002682) 2.53TIRAP, IKBKG, IRAK4
regulation of defense response (GO:0031347) 3.113TIRAP, IKBKG, IRAK4
toll-like receptor signaling pathway (GO:0002224) 5.263TIRAP, IKBKG, IRAK4
biological regulation (GO:0065007) 0.393TIRAP, IKBKG, IRAK4
pattern recognition receptor signaling pathway (GO:0002221) 5.023TIRAP, IKBKG, IRAK4
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 4.273TIRAP, IKBKG, IRAK4
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 4.543TIRAP, IKBKG, IRAK4
positive regulation of innate immune response (GO:0045089) 4.223TIRAP, IKBKG, IRAK4
regulation of innate immune response (GO:0045088) 3.863TIRAP, IKBKG, IRAK4
innate immune response (GO:0045087) 3.553TIRAP, IKBKG, IRAK4
cellular process (GO:0009987) 0.263TIRAP, IKBKG, IRAK4
regulation of cellular process (GO:0050794) 0.53TIRAP, IKBKG, IRAK4
defense response (GO:0006952) 2.783TIRAP, IKBKG, IRAK4
positive regulation of biological process (GO:0048518) 1.23TIRAP, IKBKG, IRAK4
response to stress (GO:0006950) 1.83TIRAP, IKBKG, IRAK4
regulation of immune response (GO:0050776) 2.983TIRAP, IKBKG, IRAK4
single-organism cellular process (GO:0044763) 0.653TIRAP, IKBKG, IRAK4
immune response (GO:0006955) 2.863TIRAP, IKBKG, IRAK4
positive regulation of intracellular signal transduction (GO:1902533) 2.953TIRAP, IKBKG, IRAK4
regulation of intracellular signal transduction (GO:1902531) 2.313TIRAP, IKBKG, IRAK4
positive regulation of signaling (GO:0023056) 2.413TIRAP, IKBKG, IRAK4
immune response-activating signal transduction (GO:0002757) 3.83TIRAP, IKBKG, IRAK4
response to stimulus (GO:0050896) 1.223TIRAP, IKBKG, IRAK4
innate immune response-activating signal transduction (GO:0002758) 4.453TIRAP, IKBKG, IRAK4
positive regulation of immune response (GO:0050778) 3.43TIRAP, IKBKG, IRAK4
immune system process (GO:0002376) 2.293TIRAP, IKBKG, IRAK4
activation of innate immune response (GO:0002218) 4.413TIRAP, IKBKG, IRAK4
activation of immune response (GO:0002253) 3.673TIRAP, IKBKG, IRAK4
regulation of response to stress (GO:0080134) 2.533TIRAP, IKBKG, IRAK4
positive regulation of cellular process (GO:0048522) 1.33TIRAP, IKBKG, IRAK4
regulation of cell proliferation (GO:0042127) 2.412TIRAP, IRAK4
stress-activated MAPK cascade (GO:0051403) 5.452IKBKG, IRAK4
positive regulation of protein modification process (GO:0031401) 2.72TIRAP, IKBKG
regulation of phosphate metabolic process (GO:0019220) 2.352TIRAP, IKBKG
positive regulation of metabolic process (GO:0009893) 1.742TIRAP, IKBKG
regulation of metabolic process (GO:0019222) 1.022TIRAP, IKBKG
positive regulation of biosynthetic process (GO:0009891) 2.292TIRAP, IKBKG
MAPK cascade (GO:0000165) 3.912IKBKG, IRAK4
positive regulation of cellular metabolic process (GO:0031325) 1.812TIRAP, IKBKG
regulation of cellular metabolic process (GO:0031323) 1.072TIRAP, IKBKG
regulation of cellular biosynthetic process (GO:0031326) 1.382TIRAP, IKBKG
positive regulation of protein metabolic process (GO:0051247) 2.432TIRAP, IKBKG
metabolic process (GO:0008152) 0.582IKBKG, IRAK4
regulation of phosphorus metabolic process (GO:0051174) 2.352TIRAP, IKBKG
positive regulation of protein phosphorylation (GO:0001934) 2.952TIRAP, IKBKG
intracellular signal transduction (GO:0035556) 2.392IKBKG, IRAK4
regulation of cellular protein metabolic process (GO:0032268) 1.992TIRAP, IKBKG
signal transduction by protein phosphorylation (GO:0023014) 3.792IKBKG, IRAK4
regulation of MAPK cascade (GO:0043408) 3.222TIRAP, IKBKG
cellular protein metabolic process (GO:0044267) 1.632IKBKG, IRAK4
single-organism metabolic process (GO:0044710) 1.632IKBKG, IRAK4
positive regulation of macromolecule metabolic process (GO:0010604) 1.812TIRAP, IKBKG
response to external biotic stimulus (GO:0043207) 3.132TIRAP, IKBKG
positive regulation of phosphorus metabolic process (GO:0010562) 2.782TIRAP, IKBKG
positive regulation of cellular biosynthetic process (GO:0031328) 2.32TIRAP, IKBKG
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462TIRAP, IKBKG
phosphate-containing compound metabolic process (GO:0006796) 2.162IKBKG, IRAK4
organic substance metabolic process (GO:0071704) 0.632IKBKG, IRAK4
regulation of protein metabolic process (GO:0051246) 1.932TIRAP, IKBKG
positive regulation of cellular protein metabolic process (GO:0032270) 2.492TIRAP, IKBKG
positive regulation of molecular function (GO:0044093) 2.232TIRAP, IKBKG
regulation of protein modification process (GO:0031399) 2.322TIRAP, IKBKG
regulation of macromolecule metabolic process (GO:0060255) 1.082TIRAP, IKBKG
negative regulation of biological process (GO:0048519) 1.332TIRAP, IKBKG
regulation of molecular function (GO:0065009) 1.782TIRAP, IKBKG
positive regulation of NF-kappaB transcription factor activity (GO:0051092) 4.852TIRAP, IKBKG
regulation of gene expression (GO:0010468) 1.372TIRAP, IKBKG
stress-activated protein kinase signaling cascade (GO:0031098) 5.412IKBKG, IRAK4
positive regulation of cell proliferation (GO:0008284) 3.012TIRAP, IRAK4
protein phosphorylation (GO:0006468) 2.892IKBKG, IRAK4
positive regulation of phosphate metabolic process (GO:0045937) 2.782TIRAP, IKBKG
MyD88-dependent toll-like receptor signaling pathway (GO:0002755) 6.22TIRAP, IRAK4
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432TIRAP, IKBKG
regulation of biosynthetic process (GO:0009889) 1.372TIRAP, IKBKG
JNK cascade (GO:0007254) 5.742IKBKG, IRAK4
cellular protein modification process (GO:0006464) 1.792IKBKG, IRAK4
positive regulation of MAPK cascade (GO:0043410) 3.572TIRAP, IKBKG
macromolecule modification (GO:0043412) 1.732IKBKG, IRAK4
protein modification process (GO:0036211) 1.792IKBKG, IRAK4
regulation of nucleic acid-templated transcription (GO:1903506) 1.552TIRAP, IKBKG
inflammatory response (GO:0006954) 3.642TIRAP, IKBKG
regulation of RNA biosynthetic process (GO:2001141) 1.552TIRAP, IKBKG
response to other organism (GO:0051707) 3.482TIRAP, IKBKG
regulation of primary metabolic process (GO:0080090) 1.082TIRAP, IKBKG
multi-organism process (GO:0051704) 2.652TIRAP, IKBKG
regulation of phosphorylation (GO:0042325) 2.52TIRAP, IKBKG
primary metabolic process (GO:0044238) 0.692IKBKG, IRAK4
positive regulation of phosphorylation (GO:0042327) 2.92TIRAP, IKBKG
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832TIRAP, IKBKG
response to biotic stimulus (GO:0009607) 3.092TIRAP, IKBKG
cellular macromolecule metabolic process (GO:0044260) 0.932IKBKG, IRAK4
response to external stimulus (GO:0009605) 2.552TIRAP, IKBKG
protein metabolic process (GO:0019538) 1.452IKBKG, IRAK4
phosphorylation (GO:0016310) 2.632IKBKG, IRAK4
regulation of RNA metabolic process (GO:0051252) 1.522TIRAP, IKBKG
cellular metabolic process (GO:0044237) 0.692IKBKG, IRAK4
macromolecule metabolic process (GO:0043170) 0.832IKBKG, IRAK4
regulation of transcription, DNA-templated (GO:0006355) 1.562TIRAP, IKBKG
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392TIRAP, IKBKG
regulation of macromolecule biosynthetic process (GO:0010556) 1.432TIRAP, IKBKG
cellular response to stress (GO:0033554) 2.512IKBKG, IRAK4
phosphorus metabolic process (GO:0006793) 2.152IKBKG, IRAK4
regulation of protein phosphorylation (GO:0001932) 2.572TIRAP, IKBKG
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.292TIRAP, IKBKG
regulation of nitrogen compound metabolic process (GO:0051171) 1.362TIRAP, IKBKG

NET-GE enrichment

Term New enriched termICP valueGenes
macrophage activation (GO:0042116) NEW6.290.031TIRAP, IKBKG
toll-like receptor 2 signaling pathway (GO:0034134) NEW7.940.0TIRAP, IKBKG, IRAK4
regulation of interferon-beta production (GO:0032648) NEW5.920.028TIRAP, IKBKG
positive regulation of defense response (GO:0031349) -3.830.001TIRAP, IKBKG, IRAK4
toll-like receptor TLR1:TLR2 signaling pathway (GO:0038123) NEW8.630.0TIRAP, IKBKG, IRAK4
regulation of response to cytokine stimulus (GO:0060759) NEW4.770.003TIRAP, IKBKG, IRAK4
toll-like receptor TLR6:TLR2 signaling pathway (GO:0038124) NEW8.340.0TIRAP, IKBKG, IRAK4
regulation of defense response (GO:0031347) -3.110.007TIRAP, IKBKG, IRAK4
JNK cascade (GO:0007254) -5.740.009IKBKG, IRAK4
immune response-regulating signaling pathway (GO:0002764) -3.720.009TIRAP, IKBKG, IRAK4
response to virus (GO:0009615) NEW4.210.044TIRAP, IKBKG, IRAK4
stress-activated protein kinase signaling cascade (GO:0031098) -5.410.024IKBKG, IRAK4
positive regulation of immune system process (GO:0002684) -2.960.034TIRAP, IKBKG, IRAK4
toll-like receptor signaling pathway (GO:0002224) -5.260.0TIRAP, IKBKG, IRAK4
pattern recognition receptor signaling pathway (GO:0002221) -5.020.003TIRAP, IKBKG, IRAK4
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) -4.270.022TIRAP, IKBKG, IRAK4
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) -4.540.005TIRAP, IKBKG, IRAK4
positive regulation of innate immune response (GO:0045089) -4.220.012TIRAP, IKBKG, IRAK4
regulation of innate immune response (GO:0045088) -3.860.001TIRAP, IKBKG, IRAK4
immune response-activating signal transduction (GO:0002757) -3.80.005TIRAP, IKBKG, IRAK4
innate immune response (GO:0045087) -3.550.027TIRAP, IKBKG, IRAK4
positive regulation of toll-like receptor signaling pathway (GO:0034123) NEW6.780.01TIRAP, IRAK4
toll-like receptor 9 signaling pathway (GO:0034162) NEW7.020.015IKBKG, IRAK4
positive regulation of toll-like receptor 4 signaling pathway (GO:0034145) NEW7.430.001TIRAP, IRAK4
toll-like receptor 5 signaling pathway (GO:0034146) NEW9.730.012IKBKG, IRAK4
stress-activated MAPK cascade (GO:0051403) -5.450.023IKBKG, IRAK4
toll-like receptor 10 signaling pathway (GO:0034166) NEW9.730.012IKBKG, IRAK4
innate immune response-activating signal transduction (GO:0002758) -4.450.003TIRAP, IKBKG, IRAK4
toll-like receptor 4 signaling pathway (GO:0034142) NEW6.840.001TIRAP, IKBKG, IRAK4
positive regulation of intracellular signal transduction (GO:1902533) -2.950.018TIRAP, IKBKG, IRAK4
positive regulation of NF-kappaB transcription factor activity (GO:0051092) -4.850.045TIRAP, IKBKG
MyD88-dependent toll-like receptor signaling pathway (GO:0002755) -6.20.0TIRAP, IKBKG, IRAK4
regulation of immune response (GO:0050776) -2.980.044TIRAP, IKBKG, IRAK4
regulation of cytokine-mediated signaling pathway (GO:0001959) NEW4.820.002TIRAP, IKBKG, IRAK4
regulation of response to stress (GO:0080134) -2.530.045TIRAP, IKBKG, IRAK4
I-kappaB kinase/NF-kappaB signaling (GO:0007249) NEW5.670.031TIRAP, IKBKG
positive regulation of immune response (GO:0050778) -3.40.014TIRAP, IKBKG, IRAK4
activation of innate immune response (GO:0002218) -4.410.004TIRAP, IKBKG, IRAK4
activation of immune response (GO:0002253) -3.670.007TIRAP, IKBKG, IRAK4
regulation of type I interferon production (GO:0032479) NEW5.030.034TIRAP, IKBKG
positive regulation of interleukin-12 production (GO:0032735) NEW6.230.03TIRAP, IKBKG
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.013TIRAP, IKBKG, IRAK4
intracellular membrane-bounded organelle (GO:0043231) 0.63TIRAP, IKBKG, IRAK4
cytosol (GO:0005829) 1.683TIRAP, IKBKG, IRAK4
cell part (GO:0044464) 0.113TIRAP, IKBKG, IRAK4
cytoplasmic part (GO:0044444) 0.823TIRAP, IKBKG, IRAK4
intracellular organelle part (GO:0044446) 0.813TIRAP, IKBKG, IRAK4
intracellular organelle (GO:0043229) 0.513TIRAP, IKBKG, IRAK4
intracellular part (GO:0044424) 0.283TIRAP, IKBKG, IRAK4
membrane-bounded organelle (GO:0043227) 0.473TIRAP, IKBKG, IRAK4
organelle (GO:0043226) 0.43TIRAP, IKBKG, IRAK4
organelle part (GO:0044422) 0.793TIRAP, IKBKG, IRAK4
nucleus (GO:0005634) 1.072IKBKG, IRAK4
membrane (GO:0016020) 0.682TIRAP, IRAK4
extracellular region part (GO:0044421) 1.572TIRAP, IRAK4
intracellular (GO:0005622) 2.372IKBKG, IRAK4
plasma membrane (GO:0005886) 1.392TIRAP, IRAK4