Disease table of PREECLAMPSIA/ECLAMPSIA OMIM ID: PS189800

Gene-disease associations table

GeneAssociated with PREECLAMPSIA/ECLAMPSIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CORINClinVar, OMIM, HUMSAVARHGNC link4p121PS189800
EPHX1OMIMHGNC link1q42.122PS189800, 607748
AGTOMIMHGNC link1q42.23PS189800, 267430, 145500
STOX1ClinVar, OMIM, HUMSAVARHGNC link10q22.11PS189800
NOS3OMIMHGNC link7q36.14145500, PS189800, 104300, 601367

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
1q422EPHX1, AGT
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
1q42EPHX1, AGT
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1q2EPHX1, AGT
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
12EPHX1, AGT
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12NOS3, AGT
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC62NOS3, AGT
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC62NOS3, AGT
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
AGTYES5SP1, YBX1, NFKB1, USF1, RELA0
NOS3YES11SP1, GATA4, HDAC1, DDIT3, ATF2, JUN, RELA, SP3, NFKB1, GATA2, KLF20
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
AGTNOS3No-28EDNRB, EDNRA, BDKRB2, GNG2, OXT, PLCG1, TP53, APLN, KNG1, GNAI1, GCG, INS, CXCL12, ACE, RAF1, GNB1, AVP, AGTR1, CNR1, DNM1, SRC, EDN1, STAT3, GNRH1, GNAI3, IL6, PTGER3, HIF1A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
Renin-angiotensin system (hsa04614) NEW8.680.007NOS3, AGT
Circulatory systemNEW4.630.034AGT, NOS3, EPHX1
VEGF signaling pathway (hsa04370) NEW6.770.041NOS3, AGT
Vascular smooth muscle contraction (hsa04270) NEW5.740.003AGT, NOS3, EPHX1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.342NOS3, AGT
Signal TransductionR-HSA-1625821.782NOS3, AGT

NET-GE enrichment

Term New enriched termICP valueGenes
PI3K/AKT Signaling in Cancer (R-HSA-2219528) NEW6.560.046NOS3, AGT
ECM proteoglycans (R-HSA-3000178) NEW6.750.034NOS3, AGT
Costimulation by the CD28 family (R-HSA-388841) NEW6.560.042NOS3, AGT
VEGFR2 mediated vascular permeability (R-HSA-5218920) NEW8.280.002NOS3, AGT
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.053NOS3, EPHX1, CORIN
binding (GO:0005488) 0.183NOS3, AGT, STOX1
protein binding (GO:0005515) 0.463NOS3, AGT, STOX1
hydrolase activity (GO:0016787) 1.92EPHX1, CORIN
heterocyclic compound binding (GO:1901363) 1.062NOS3, STOX1
organic cyclic compound binding (GO:0097159) 1.052NOS3, STOX1

NET-GE enrichment

Term New enriched termICP valueGenes
serine-type endopeptidase activity (GO:0004252) NEW4.40.039NOS3, AGT, CORIN
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.265AGT, STOX1, EPHX1, NOS3, CORIN
metabolic process (GO:0008152) 0.585AGT, NOS3, EPHX1, STOX1, CORIN
cellular metabolic process (GO:0044237) 0.695AGT, STOX1, EPHX1, NOS3, CORIN
primary metabolic process (GO:0044238) 0.694STOX1, AGT, NOS3, CORIN
response to stimulus (GO:0050896) 1.224EPHX1, NOS3, AGT, STOX1
organic substance metabolic process (GO:0071704) 0.634NOS3, AGT, STOX1, CORIN
cellular nitrogen compound metabolic process (GO:0034641) 1.224NOS3, AGT, STOX1, CORIN
nitrogen compound metabolic process (GO:0006807) 1.134STOX1, AGT, NOS3, CORIN
biological regulation (GO:0065007) 0.394STOX1, AGT, NOS3, CORIN
regulation of multicellular organismal process (GO:0051239) 1.874STOX1, AGT, NOS3, CORIN
regulation of signaling (GO:0023051) 1.724NOS3, AGT, STOX1, CORIN
regulation of biological quality (GO:0065008) 1.684NOS3, AGT, STOX1, CORIN
regulation of biological process (GO:0050789) 0.454NOS3, AGT, STOX1, CORIN
developmental process (GO:0032502) 1.363NOS3, AGT, STOX1
regulation of phosphate metabolic process (GO:0019220) 2.353NOS3, AGT, STOX1
positive regulation of metabolic process (GO:0009893) 1.743NOS3, AGT, STOX1
regulation of metabolic process (GO:0019222) 1.023NOS3, AGT, STOX1
regulation of anatomical structure morphogenesis (GO:0022603) 2.793NOS3, AGT, STOX1
regulation of transport (GO:0051049) 2.243NOS3, AGT, CORIN
positive regulation of cellular metabolic process (GO:0031325) 1.813NOS3, AGT, STOX1
regulation of response to stimulus (GO:0048583) 1.543STOX1, AGT, NOS3
multicellular organismal process (GO:0032501) 1.453NOS3, AGT, CORIN
regulation of blood pressure (GO:0008217) 4.723NOS3, AGT, CORIN
regulation of cell communication (GO:0010646) 1.733NOS3, AGT, STOX1
single-organism process (GO:0044699) 0.483STOX1, AGT, NOS3
regulation of primary metabolic process (GO:0080090) 1.083NOS3, AGT, STOX1
regulation of systemic arterial blood pressure (GO:0003073) 5.993NOS3, AGT, CORIN
regulation of systemic arterial blood pressure by hormone (GO:0001990) 6.433NOS3, AGT, CORIN
endocrine process (GO:0050886) 6.433NOS3, AGT, CORIN
regulation of system process (GO:0044057) 3.533NOS3, AGT, CORIN
regulation of signal transduction (GO:0009966) 1.843NOS3, AGT, STOX1
positive regulation of multicellular organismal process (GO:0051240) 2.493NOS3, AGT, STOX1
cellular component organization (GO:0016043) 1.243STOX1, AGT, NOS3
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433STOX1, AGT, NOS3
cellular component organization or biogenesis (GO:0071840) 1.223NOS3, AGT, STOX1
positive regulation of molecular function (GO:0044093) 2.233NOS3, AGT, STOX1
regulation of cellular biosynthetic process (GO:0031326) 1.383STOX1, AGT, NOS3
positive regulation of biological process (GO:0048518) 1.23STOX1, AGT, NOS3
negative regulation of biological process (GO:0048519) 1.333STOX1, AGT, NOS3
regulation of molecular function (GO:0065009) 1.783NOS3, AGT, STOX1
system process (GO:0003008) 2.33NOS3, AGT, CORIN
regulation of cell proliferation (GO:0042127) 2.413NOS3, AGT, STOX1
positive regulation of catalytic activity (GO:0043085) 2.43NOS3, AGT, STOX1
regulation of heart contraction (GO:0008016) 4.353NOS3, AGT, CORIN
positive regulation of phosphate metabolic process (GO:0045937) 2.783NOS3, AGT, STOX1
regulation of developmental process (GO:0050793) 2.13NOS3, AGT, STOX1
regulation of cellular metabolic process (GO:0031323) 1.073STOX1, AGT, NOS3
regulation of catalytic activity (GO:0050790) 1.973STOX1, AGT, NOS3
regulation of biosynthetic process (GO:0009889) 1.373STOX1, AGT, NOS3
regulation of cellular process (GO:0050794) 0.53STOX1, AGT, NOS3
single-organism developmental process (GO:0044767) 1.493NOS3, AGT, STOX1
reproductive process (GO:0022414) 2.553NOS3, AGT, CORIN
response to stress (GO:0006950) 1.83NOS3, AGT, STOX1
single-organism cellular process (GO:0044763) 0.653NOS3, AGT, STOX1
regulation of nitrogen compound metabolic process (GO:0051171) 1.363STOX1, AGT, NOS3
regulation of localization (GO:0032879) 1.943NOS3, AGT, CORIN
regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) 6.363NOS3, AGT, CORIN
regulation of phosphorus metabolic process (GO:0051174) 2.353NOS3, AGT, STOX1
organonitrogen compound metabolic process (GO:1901564) 2.323NOS3, AGT, CORIN
positive regulation of developmental process (GO:0051094) 2.773NOS3, AGT, STOX1
regulation of response to stress (GO:0080134) 2.533NOS3, AGT, STOX1
anatomical structure development (GO:0048856) 1.583STOX1, AGT, NOS3
macromolecule metabolic process (GO:0043170) 0.833STOX1, AGT, CORIN
regulation of multicellular organismal development (GO:2000026) 2.313NOS3, AGT, STOX1
regulation of blood circulation (GO:1903522) 4.053NOS3, AGT, CORIN
positive regulation of phosphorus metabolic process (GO:0010562) 2.783STOX1, AGT, NOS3
positive regulation of cellular process (GO:0048522) 1.33STOX1, AGT, NOS3
regulation of extrinsic apoptotic signaling pathway (GO:2001236) 4.692NOS3, AGT
regulation of secretion (GO:0051046) 3.22AGT, CORIN
regulation of apoptotic signaling pathway (GO:2001233) 3.832NOS3, AGT
negative regulation of response to stimulus (GO:0048585) 2.522NOS3, AGT
positive regulation of response to stimulus (GO:0048584) 2.182STOX1, AGT
tissue remodeling (GO:0048771) 5.542NOS3, AGT
regulation of homeostatic process (GO:0032844) 3.652AGT, CORIN
muscle system process (GO:0003012) 4.182NOS3, AGT
circulatory system process (GO:0003013) 4.382NOS3, AGT
signal transduction (GO:0007165) 1.282NOS3, AGT
cell surface receptor signaling pathway (GO:0007166) 2.092NOS3, AGT
vascular process in circulatory system (GO:0003018) 4.652NOS3, AGT
hormone metabolic process (GO:0042445) 4.642AGT, CORIN
single-organism metabolic process (GO:0044710) 1.632NOS3, AGT
negative regulation of macromolecule metabolic process (GO:0010605) 2.012STOX1, AGT
regulation of cardiac conduction (GO:1903779) 5.572AGT, CORIN
negative regulation of signal transduction (GO:0009968) 2.752NOS3, AGT
positive regulation of signal transduction (GO:0009967) 2.52STOX1, AGT
animal organ development (GO:0048513) 2.532NOS3, AGT
negative regulation of molecular function (GO:0044092) 2.742NOS3, AGT
cellular homeostasis (GO:0019725) 3.232NOS3, AGT
negative regulation of transport (GO:0051051) 3.62NOS3, AGT
regulation of macromolecule metabolic process (GO:0060255) 1.082STOX1, AGT
regulation of protein kinase activity (GO:0045859) 3.152STOX1, AGT
positive regulation of phosphorylation (GO:0042327) 2.92STOX1, AGT
positive regulation of vasodilation (GO:0045909) 6.262NOS3, AGT
regulation of RNA biosynthetic process (GO:2001141) 1.552STOX1, AGT
multi-organism process (GO:0051704) 2.652AGT, CORIN
regulation of phosphorylation (GO:0042325) 2.52STOX1, AGT
positive regulation of signaling (GO:0023056) 2.412STOX1, AGT
multi-organism reproductive process (GO:0044703) 4.822AGT, CORIN
cellular amide metabolic process (GO:0043603) 3.232AGT, CORIN
single-multicellular organism process (GO:0044707) 1.782NOS3, AGT
multi-multicellular organism process (GO:0044706) 4.922AGT, CORIN
protein metabolic process (GO:0019538) 1.452AGT, CORIN
cellular response to stress (GO:0033554) 2.512STOX1, AGT
regulation of membrane potential (GO:0042391) 3.892STOX1, AGT
negative regulation of metabolic process (GO:0009892) 1.932STOX1, AGT
positive regulation of kinase activity (GO:0033674) 3.542STOX1, AGT
regulation of vasculature development (GO:1901342) 4.262NOS3, AGT
positive regulation of gene expression (GO:0010628) 2.352STOX1, AGT
(GO:1905330) 4.562STOX1, AGT
second-messenger-mediated signaling (GO:0019932) 4.652NOS3, AGT
(GO:1905332) 6.362STOX1, AGT
intracellular signal transduction (GO:0035556) 2.392NOS3, AGT
regulation of apoptotic process (GO:0042981) 2.52NOS3, AGT
regulation of oxidoreductase activity (GO:0051341) 5.272NOS3, AGT
positive regulation of transferase activity (GO:0051347) 3.312STOX1, AGT
negative regulation of hydrolase activity (GO:0051346) 3.742NOS3, AGT
cellular macromolecule metabolic process (GO:0044260) 0.932STOX1, AGT
regulation of kinase activity (GO:0043549) 3.072STOX1, AGT
regulation of anatomical structure size (GO:0090066) 3.782NOS3, AGT
regulation of tube size (GO:0035150) 4.792NOS3, AGT
cellular response to stimulus (GO:0051716) 1.972STOX1, AGT
positive regulation of blood circulation (GO:1903524) 5.162NOS3, AGT
positive regulation of intracellular signal transduction (GO:1902533) 2.952STOX1, AGT
regulation of intracellular signal transduction (GO:1902531) 2.312STOX1, AGT
positive regulation of macromolecule metabolic process (GO:0010604) 1.812STOX1, AGT
regulation of hydrolase activity (GO:0051336) 2.532NOS3, AGT
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592NOS3, STOX1
protein maturation (GO:0051604) 4.482AGT, CORIN
positive regulation of protein modification process (GO:0031401) 2.72STOX1, AGT
regulation of transferase activity (GO:0051338) 2.882STOX1, AGT
regulation of transcription, DNA-templated (GO:0006355) 1.562STOX1, AGT
regulation of macromolecule biosynthetic process (GO:0010556) 1.432STOX1, AGT
peptide metabolic process (GO:0006518) 3.442AGT, CORIN
regulation of response to external stimulus (GO:0032101) 3.062NOS3, AGT
regulation of cellular component organization (GO:0051128) 2.012STOX1, AGT
cellular catabolic process (GO:0044248) 2.622NOS3, EPHX1
cellular biosynthetic process (GO:0044249) 1.372NOS3, STOX1
negative regulation of cell communication (GO:0010648) 2.662NOS3, AGT
positive regulation of cell communication (GO:0010647) 2.412STOX1, AGT
negative regulation of catalytic activity (GO:0043086) 3.02NOS3, AGT
regulation of blood vessel size (GO:0050880) 4.82NOS3, AGT
catabolic process (GO:0009056) 2.382NOS3, EPHX1
negative regulation of multicellular organismal process (GO:0051241) 2.842NOS3, AGT
regulation of protein metabolic process (GO:0051246) 1.932STOX1, AGT
positive regulation of protein metabolic process (GO:0051247) 2.432STOX1, AGT
positive regulation of cellular protein metabolic process (GO:0032270) 2.492STOX1, AGT
regulation of protein modification process (GO:0031399) 2.322STOX1, AGT
proteolysis (GO:0006508) 2.732AGT, CORIN
regulation of sodium ion transport (GO:0002028) 5.42NOS3, AGT
positive regulation of cell proliferation (GO:0008284) 3.012STOX1, AGT
cellular aromatic compound metabolic process (GO:0006725) 1.32STOX1, EPHX1
regulation of nucleic acid-templated transcription (GO:1903506) 1.552STOX1, AGT
negative regulation of ion transport (GO:0043271) 4.942NOS3, AGT
protein processing (GO:0016485) 4.622AGT, CORIN
peptide hormone processing (GO:0016486) 6.292AGT, CORIN
positive regulation of biosynthetic process (GO:0009891) 2.292NOS3, AGT
regulation of cellular protein metabolic process (GO:0032268) 1.992STOX1, AGT
regulation of excretion (GO:0044062) 6.362AGT, CORIN
female pregnancy (GO:0007565) 5.082AGT, CORIN
regulation of RNA metabolic process (GO:0051252) 1.522STOX1, AGT
negative regulation of gene expression (GO:0010629) 2.482STOX1, AGT
positive regulation of protein kinase activity (GO:0045860) 3.612STOX1, AGT
positive regulation of cellular biosynthetic process (GO:0031328) 2.32NOS3, AGT
homeostatic process (GO:0042592) 2.612NOS3, AGT
regulation of cell death (GO:0010941) 2.432NOS3, AGT
regulation of muscle adaptation (GO:0043502) 5.782NOS3, AGT
regulation of vasodilation (GO:0042312) 5.862NOS3, AGT
regulation of ion transport (GO:0043269) 3.42NOS3, AGT
blood vessel remodeling (GO:0001974) 6.232NOS3, AGT
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462STOX1, AGT
regulation of angiogenesis (GO:0045765) 4.362NOS3, AGT
regulation of renal system process (GO:0098801) 6.122AGT, CORIN
regulation of programmed cell death (GO:0043067) 2.492NOS3, AGT
regulation of renal sodium excretion (GO:0035813) 6.552AGT, CORIN
regulation of gene expression (GO:0010468) 1.372STOX1, AGT
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352NOS3, AGT
regulation of hormone levels (GO:0010817) 3.562AGT, CORIN
regulation of metal ion transport (GO:0010959) 3.942NOS3, AGT
biosynthetic process (GO:0009058) 1.322NOS3, STOX1
regulation of muscle system process (GO:0090257) 4.512NOS3, AGT
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292NOS3, AGT
nitric oxide mediated signal transduction (GO:0007263) 6.782NOS3, AGT
organelle organization (GO:0006996) 2.022NOS3, STOX1
response to abiotic stimulus (GO:0009628) 2.82NOS3, AGT
regulation of calcium ion transport (GO:0051924) 4.382NOS3, AGT
regulation of ion homeostasis (GO:2000021) 4.442AGT, CORIN
regulation of organ morphogenesis (GO:2000027) 4.222STOX1, AGT
regulation of protein phosphorylation (GO:0001932) 2.572STOX1, AGT
negative regulation of signaling (GO:0023057) 2.652NOS3, AGT
positive regulation of protein phosphorylation (GO:0001934) 2.952STOX1, AGT
negative regulation of cellular process (GO:0048523) 1.412NOS3, AGT

NET-GE enrichment

Term New enriched termICP valueGenes
negative regulation of muscle hypertrophy (GO:0014741) NEW7.090.021NOS3, AGT
response to oxygen radical (GO:0000305) NEW7.650.033NOS3, AGT
response to superoxide (GO:0000303) NEW7.780.031NOS3, AGT
regulation of cholesterol metabolic process (GO:0090181) NEW6.640.037NOS3, AGT
regulation of superoxide metabolic process (GO:0090322) NEW6.640.016NOS3, AGT
regulation of blood pressure (GO:0008217) -4.720.001NOS3, AGT, CORIN
positive regulation of striated muscle contraction (GO:0045989) NEW6.960.005NOS3, AGT
regulation of muscle adaptation (GO:0043502) -5.780.015NOS3, AGT
regulation of systemic arterial blood pressure (GO:0003073) -5.990.0NOS3, AGT, CORIN
superoxide anion generation (GO:0042554) NEW7.090.021NOS3, AGT
peptide hormone processing (GO:0016486) -6.290.011NOS3, AGT, CORIN
endocrine process (GO:0050886) -6.430.0NOS3, AGT, CORIN
regulation of system process (GO:0044057) -3.530.02NOS3, AGT, CORIN
angiotensin maturation (GO:0002003) NEW7.330.033NOS3, AGT
mesonephros development (GO:0001823) NEW7.160.021NOS3, AGT
regulation of renal sodium excretion (GO:0035813) -6.550.0NOS3, AGT, CORIN
epoxygenase P450 pathway (GO:0019373) NEW6.840.019NOS3, AGT
regulation of sodium ion transport (GO:0002028) -5.40.034NOS3, AGT
regulation of tube size (GO:0035150) -4.790.041NOS3, AGT
smooth muscle adaptation (GO:0014805) NEW8.340.001NOS3, AGT
regulation of blood vessel size (GO:0050880) -4.80.039NOS3, AGT
regulation of systemic arterial blood pressure by hormone (GO:0001990) -6.430.0NOS3, AGT, CORIN
nitric oxide mediated signal transduction (GO:0007263) -6.780.003NOS3, AGT
regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044) -6.360.0NOS3, AGT, CORIN
regulation of excretion (GO:0044062) -6.360.0NOS3, AGT, CORIN
positive regulation of systemic arterial blood pressure (GO:0003084) NEW7.430.027NOS3, AGT
blood vessel remodeling (GO:0001974) -6.230.014NOS3, AGT
positive regulation of cardiac muscle contraction (GO:0060452) NEW7.240.002NOS3, AGT
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.115AGT, STOX1, EPHX1, NOS3, CORIN
intracellular part (GO:0044424) 0.284EPHX1, NOS3, AGT, STOX1
membrane-bounded organelle (GO:0043227) 0.474AGT, STOX1, EPHX1, NOS3
organelle (GO:0043226) 0.44AGT, STOX1, EPHX1, NOS3
cytoplasm (GO:0005737) 1.013STOX1, AGT, NOS3
intracellular membrane-bounded organelle (GO:0043231) 0.63NOS3, EPHX1, STOX1
membrane (GO:0016020) 0.683NOS3, EPHX1, CORIN
cytoplasmic part (GO:0044444) 0.823NOS3, EPHX1, STOX1
intracellular organelle part (GO:0044446) 0.813NOS3, EPHX1, STOX1
intracellular organelle (GO:0043229) 0.513NOS3, EPHX1, STOX1
membrane part (GO:0044425) 0.953NOS3, EPHX1, CORIN
organelle part (GO:0044422) 0.793NOS3, EPHX1, STOX1
cytoskeleton (GO:0005856) 2.552NOS3, STOX1
organelle membrane (GO:0031090) 1.972NOS3, EPHX1
intracellular non-membrane-bounded organelle (GO:0043232) 1.762NOS3, STOX1
integral component of membrane (GO:0016021) 1.142EPHX1, CORIN
non-membrane-bounded organelle (GO:0043228) 1.762NOS3, STOX1
plasma membrane (GO:0005886) 1.392NOS3, CORIN
plasma membrane part (GO:0044459) 1.952NOS3, CORIN
nucleus (GO:0005634) 1.072NOS3, STOX1
intrinsic component of membrane (GO:0031224) 1.132EPHX1, CORIN
extracellular region (GO:0005576) 2.182AGT, CORIN