Gene table of ERBB4 : erb-b2 receptor tyrosine kinase 4

Gene-disease associations table

Disease IDDisease nameSource of annotation with ERBB4OMIM linkNumber of associated genesgenes
PS105400AMYOTROPHIC LATERAL SCLEROSISClinVar, OMIM, HUMSAVAR link to OMIM 27CHCHD10, FIG4, ERBB4, SQSTM1, ATXN2, UBQLN2, DCTN1, FUS, NEFH, PFN1, VAPB, MATR3, ALS2, TBK1, SPG11, TARDBP, TUBA4A, SIGMAR1, SOD1, CHMP2B, PRPH, ANG, VCP, OPTN, C9orf72, HNRNPA1, SETX

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Annotation of the gene ERBB4

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Proteoglycans in cancerhsa052055.02
Calcium signaling pathwayhsa040205.22
ErbB signaling pathwayhsa040126.15
Endocytosishsa041444.92
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
NCAM signaling for neurite out-growthR-HSA-3751654.9
PI3K/AKT activationR-HSA-1982036.32
Signaling by InterleukinsR-HSA-4491474.71
PI3K events in ERBB4 signalingR-HSA-12503426.37
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
Signaling by LeptinR-HSA-25865525.1
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.05
PI3K events in ERBB2 signalingR-HSA-19636426.37
Cytokine Signaling in Immune systemR-HSA-12802153.74
IGF1R signaling cascadeR-HSA-24289244.85
Downstream signal transductionR-HSA-1867634.65
GAB1 signalosomeR-HSA-1802926.31
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by ERBB4R-HSA-12363944.7
IRS-mediated signallingR-HSA-1123994.87
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
DiseaseR-HSA-16436853.33
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
Downstream signaling of activated FGFR1R-HSA-56546874.71
MAPK family signaling cascadesR-HSA-56830574.89
PIP3 activates AKT signalingR-HSA-12576046.37
PI-3K cascade:FGFR3R-HSA-56547106.37
Signaling by VEGFR-HSA-1941384.66
Signalling to p38 via RIT and RINR-HSA-1877065.12
PI-3K cascade:FGFR1R-HSA-56546896.37
FCERI mediated MAPK activationR-HSA-28717964.32
Signaling by EGFRR-HSA-1779294.59
FRS-mediated FGFR2 signalingR-HSA-56547005.14
DAP12 interactionsR-HSA-21721274.56
FRS-mediated FGFR3 signalingR-HSA-56547065.14
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Signaling by Insulin receptorR-HSA-747524.73
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
Downstream signaling of activated FGFR3R-HSA-56547084.71
RAF/MAP kinase cascadeR-HSA-56730015.15
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Interleukin receptor SHC signalingR-HSA-9125265.09
Downregulation of ERBB4 signalingR-HSA-12532889.98
Signaling by FGFRR-HSA-1902364.67
PI3K/AKT Signaling in CancerR-HSA-22195286.56
Diseases of signal transductionR-HSA-56632024.89
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Immune SystemR-HSA-1682562.37
Downstream signaling of activated FGFR4R-HSA-56547164.71
Innate Immune SystemR-HSA-1682493.17
Signaling by SCF-KITR-HSA-14335574.73
Interleukin-2 signalingR-HSA-4519275.05
SHC1 events in ERBB2 signalingR-HSA-12501965.15
Developmental BiologyR-HSA-12667383.48
Signaling by ERBB2R-HSA-12279864.66
Signalling to RASR-HSA-1670445.08
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
PI-3K cascade:FGFR2R-HSA-56546956.37
Downstream signaling of activated FGFR2R-HSA-56546964.71
Signaling by FGFR1R-HSA-56547364.69
SHC1 events in EGFR signalingR-HSA-1803365.15
Nuclear signaling by ERBB4R-HSA-12519857.7
FRS-mediated FGFR1 signalingR-HSA-56546935.14
Prolonged ERK activation eventsR-HSA-1698935.11
FRS-mediated FGFR4 signalingR-HSA-56547125.14
Signalling by NGFR-HSA-1665204.23
Signaling by GPCRR-HSA-3727902.68
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signalling to ERKsR-HSA-1876875.04
Insulin receptor signalling cascadeR-HSA-747514.85
ARMS-mediated activationR-HSA-1709845.12
Frs2-mediated activationR-HSA-1709685.12
PI-3K cascade:FGFR4R-HSA-56547206.37
SOS-mediated signallingR-HSA-1124125.15
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Axon guidanceR-HSA-4224753.93
VEGFR2 mediated cell proliferationR-HSA-52189215.07
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
Ras guanyl-nucleotide exchange factor activityGO:00050884.31
signaling receptor activityGO:00380232.49
nucleic acid bindingGO:00036761.44
regulatory region DNA bindingGO:00009753.03
purine ribonucleoside triphosphate bindingGO:00356392.22
guanyl-nucleotide exchange factor activityGO:00050854.02
heterocyclic compound bindingGO:19013631.06
molecular transducer activityGO:00600892.32
bindingGO:00054880.18
phosphatidylinositol 3-kinase activityGO:00350045.49
DNA bindingGO:00036771.92
molecular function regulatorGO:00987722.51
transmembrane receptor activityGO:00996002.53
purine nucleoside bindingGO:00018832.22
nucleoside bindingGO:00018822.21
phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469345.61
protein tyrosine kinase activityGO:00047134.54
receptor signaling protein activityGO:00050574.76
transmembrane receptor protein tyrosine kinase activityGO:00047145.55
nucleotide bindingGO:00001661.96
receptor signaling protein tyrosine kinase activityGO:00047167.44
phosphatidylinositol bisphosphate kinase activityGO:00528135.56
transferase activityGO:00167401.95
nucleoside phosphate bindingGO:19012651.96
protein kinase activityGO:00046723.27
purine nucleotide bindingGO:00170762.19
ATP bindingGO:00055242.43
protein homodimerization activityGO:00428033.16
kinase activityGO:00163012.93
epidermal growth factor receptor bindingGO:00051546.34
ribonucleoside bindingGO:00325492.22
regulatory region nucleic acid bindingGO:00010673.03
small molecule bindingGO:00360941.89
catalytic activityGO:00038241.05
signal transducer activityGO:00048712.28
receptor bindingGO:00051022.43
transcription regulatory region DNA bindingGO:00442123.03
adenyl nucleotide bindingGO:00305542.4
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
growth factor receptor bindingGO:00708514.87
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
transmembrane signaling receptor activityGO:00048882.57
adenyl ribonucleotide bindingGO:00325592.41
identical protein bindingGO:00428022.63
protein bindingGO:00055150.46
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
purine ribonucleotide bindingGO:00325552.2
protein dimerization activityGO:00469832.72
transmembrane receptor protein kinase activityGO:00191995.32
purine ribonucleoside bindingGO:00325502.22
ribonucleotide bindingGO:00325532.19
receptor activityGO:00048722.32