| Disease ID | Disease name | Source of annotation with TBK1 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS105400 | AMYOTROPHIC LATERAL SCLEROSIS | ClinVar, OMIM, HUMSAVAR | link to OMIM | 27 | CHCHD10, FIG4, ERBB4, SQSTM1, ATXN2, UBQLN2, DCTN1, FUS, NEFH, PFN1, VAPB, MATR3, ALS2, TBK1, SPG11, TARDBP, TUBA4A, SIGMAR1, SOD1, CHMP2B, PRPH, ANG, VCP, OPTN, C9orf72, HNRNPA1, SETX |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Toll-like receptor signaling pathway | hsa04620 | 6.0 |
| RIG-I-like receptor signaling pathway | hsa04622 | 6.62 |
| Cytosolic DNA-sensing pathway | hsa04623 | 6.79 |
| Ras signaling pathway | hsa04014 | 4.9 |
| Herpes simplex infection | hsa05168 | 5.08 |
| Epstein-Barr virus infection | hsa05169 | 4.97 |
| Influenza A | hsa05164 | 5.21 |
| Hepatitis C | hsa05160 | 5.68 |
| Hepatitis B | hsa05161 | 5.52 |
| Measles | hsa05162 | 5.6 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| TRIF-mediated TLR3/TLR4 signaling | R-HSA-937061 | 6.47 |
| IRF3-mediated induction of type I IFN | R-HSA-3270619 | 9.28 |
| Immune System | R-HSA-168256 | 2.37 |
| TRAF6 mediated IRF7 activation | R-HSA-933541 | 7.98 |
| Regulation of innate immune responses to cytosolic DNA | R-HSA-3134975 | 9.08 |
| TRAF3-dependent IRF activation pathway | R-HSA-918233 | 9.18 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.11 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 6.47 |
| Toll-Like Receptors Cascades | R-HSA-168898 | 5.91 |
| STAT6-mediated induction of chemokines | R-HSA-3249367 | 11.4 |
| Negative regulators of RIG-I/MDA5 signaling | R-HSA-936440 | 7.98 |
| Cytosolic sensors of pathogen-associated DNA | R-HSA-1834949 | 6.94 |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | R-HSA-168928 | 6.7 |
| MyD88-independent TLR3/TLR4 cascade | R-HSA-166166 | 6.47 |
| ZBP1(DAI) mediated induction of type I IFNs | R-HSA-1606322 | 8.28 |
| Activated TLR4 signalling | R-HSA-166054 | 6.27 |
| Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | R-HSA-936964 | 8.81 |
| STING mediated induction of host immune responses | R-HSA-1834941 | 8.98 |
| IRF3 mediated activation of type 1 IFN | R-HSA-1606341 | 10.4 |
| GO term | GO ID | GO IC |
|---|---|---|
| purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
| binding | GO:0005488 | 0.18 |
| nucleic acid binding | GO:0003676 | 1.44 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| purine nucleoside binding | GO:0001883 | 2.22 |
| nucleoside binding | GO:0001882 | 2.21 |
| nucleotide binding | GO:0000166 | 1.96 |
| protein serine/threonine kinase activity | GO:0004674 | 3.64 |
| transferase activity | GO:0016740 | 1.95 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| ribonucleoside binding | GO:0032549 | 2.22 |
| purine nucleotide binding | GO:0017076 | 2.19 |
| ATP binding | GO:0005524 | 2.43 |
| kinase activity | GO:0016301 | 2.93 |
| protein kinase activity | GO:0004672 | 3.27 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| adenyl nucleotide binding | GO:0030554 | 2.4 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| phosphoprotein binding | GO:0051219 | 5.64 |
| phosphotransferase activity, alcohol group as acceptor | GO:0016773 | 3.08 |
| adenyl ribonucleotide binding | GO:0032559 | 2.41 |
| protein binding | GO:0005515 | 0.46 |
| transferase activity, transferring phosphorus-containing groups | GO:0016772 | 2.77 |
| purine ribonucleotide binding | GO:0032555 | 2.2 |
| purine ribonucleoside binding | GO:0032550 | 2.22 |
| ribonucleotide binding | GO:0032553 | 2.19 |