Gene table of IL1RN : interleukin 1 receptor antagonist

Gene-disease associations table

Disease ID	Disease name	Source of annotation with IL1RN	OMIM link	Number of associated genes	genes
PS603933	MICROVASCULAR COMPLICATIONS OF DIABETES	ClinVar, OMIM	link to OMIM	7	EPO, ACE, PON1, IL1RN, SOD2, HFE, VEGFA
612852	OSTEOMYELITIS, STERILE MULTIFOCAL, WITH PERIOSTITIS AND PUSTULOSIS	ClinVar, OMIM	link to OMIM	1	IL1RN
137215	GASTRIC CANCER, HEREDITARY DIFFUSE	OMIM	link to OMIM	4	IL1RN, CDH1, KRAS, IL1B

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Signaling by Interleukins	R-HSA-449147	4.71
Immune System	R-HSA-168256	2.37
Interleukin-1 signaling	R-HSA-446652	7.52

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cytokine receptor binding	GO:0005126	4.14
interleukin-1 binding	GO:0019966	7.79
interleukin-1, Type II receptor binding	GO:0005151	9.05
interleukin-1 Type I receptor antagonist activity	GO:0045352	9.74
interleukin-1 receptor binding	GO:0005149	6.85
interleukin-1 receptor antagonist activity	GO:0005152	8.64
cytokine binding	GO:0019955	5.21
receptor regulator activity	GO:0030545	5.91
receptor inhibitor activity	GO:0030547	7.17
growth factor binding	GO:0019838	4.89
receptor antagonist activity	GO:0048019	7.34
interleukin-1, Type I receptor binding	GO:0005150	9.05
cytokine activity	GO:0005125	4.34
binding	GO:0005488	0.18
protein binding	GO:0005515	0.46
growth factor receptor binding	GO:0070851	4.87
receptor binding	GO:0005102	2.43
molecular function regulator	GO:0098772	2.51
interleukin-1 Type II receptor antagonist activity	GO:0045353	9.74