Disease table of MICROVASCULAR COMPLICATIONS OF DIABETES OMIM ID: PS603933

Gene-disease associations table

GeneAssociated with MICROVASCULAR COMPLICATIONS OF DIABETES inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IL1RNClinVar, OMIMHGNC link2q14.13PS603933, 137215, 612852
SOD2ClinVar, OMIMHGNC link6q25.31PS603933
ACEOMIMHGNC link17q23.35PS603933, 608446, 267430, 614519, 104300
PON1ClinVar, OMIMHGNC link7q21.31PS603933
EPOClinVar, OMIMHGNC link7q22.11PS603933
VEGFAClinVar, OMIMHGNC link6p21.11PS603933
HFEClinVar, OMIMHGNC link6p22.26PS235200, PS603933, 614193, 104300, 176200, 176100

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
6p22VEGFA, HFE
7q22PON1, EPO
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
6p2VEGFA, HFE
7q2PON1, EPO
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
72PON1, EPO
63SOD2, VEGFA, HFE
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
HIF1ANO80RORA, SERPINE1, MICA, MET, WASF3, PLAU, AR, TWIST1, FAM162A, MMP2, SLC2A1, PFKFB4, EDN1, PGK1, LOX, HBEGF, FGF2, SETD2, XPC, ACE, MDK, ACE2, ERCC2, GCK, TLR2, ALOX5AP, LDHA, CXCR4, SOCS1, PPP1R3C, EDNRB, EGLN1, ALDOA, SLC29A1, AGTR1, PFKFB3, LEP, PPARA, ENO1, VHL, TWIST2, E2F3, PTGES, GAPDH, BID, MIF, CA9, CDH1, TIMP2, VIM, ALAS2, ITGB2, NT5E, CTGF, TLR6, CCR7, VEGFB, APEX1, MUC3A, EPO, MUC1, TFRC, BAX, ABCB1, NR3C1, BNIP3, RECK, TGFB3, ASS1, NR4A1, MYOCD, EGLN3, TERT, SDHB, BACE1, ZNF217, CCND1, VEGFA, CXCL12, HIF1A3EPO, VEGFA, ACE
SMAD3NO24SERPINE1, FSHB, EPO, MXD1, BGLAP, POR, BAMBI, CYP17A1, SMAD7, GLI2, TGFB1, CDKN1A, VDR, JUN, VEGFA, MYC, TNC, FSTL3, MMP9, APOC3, TERT, FOXA2, AHR, ZFP362EPO, VEGFA
XBP1NO19ERN1, NOS2, FOXO1, CXCL8, ESR1, EDEM2, ZHX2, GAD1, NPPB, HSPA1A, CCL2, IL6, WFS1, PRNP, PTGER4, ERP29, HSPA5, VEGFA, SOD22VEGFA, SOD2
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP122VEGFA, IL1RN
EGR1NO90ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG2VEGFA, ACE
JUNNO155PTN, TXN, ATF3, MEF2D, SMN1, TP53, MMP2, SPRR1B, EDN1, TNFRSF1B, NQO1, ELN, CYP19A1, GJA1, MAP3K1, ACTA1, STAR, NEIL1, ALOX12, PPARA, LOR, SLC19A1, NOS2, IFNB1, IL1B, MGMT, FGF7, JUN, ETS2, GSTP1, PCK2, BECN1, ITGB8, MMP3, CREM, IL23A, HEY1, FOSL1, CCL2, TERT, NAMPT, FASLG, BCL2L1, EGFR, RUNX2, CDKN1A, EZH2, MYB, DCN, NPY, PLAT, RARG, PTGS2, MAPK8, CCND2, NGF, TFF1, TNF, LBP, NFKB2, CYP2J2, NOX5, BEX2, NOS3, RARA, MMP1, F3, ETS1, ABCB1, STMN1, PLAUR, TNFRSF10A, IBSP, DDX21, TP73, SPRR3, PPARD, UGT2B15, RARB, IFNG, IL12A, AR, OPRM1, REN, NTS, MSR1, SYK, FOS, APP, CDK5R1, ITGAX, CCND1, CCK, PDK1, CYP1A2, BRCA1, CTSL, MMP20, MAT2A, PDHA1, SPP1, TIMP2, OXTR, VEGFA, SOX7, RHOB, CA2, IL24, CXCL8, IL2, EZR, IL1A, APOC3, MMP9, FGL2, NEFL, SOD2, BATF3, POLD2, FIGF, PLAU, DDIT3, PENK, PGR, IL12B, LGALS3, RELB, LDHA, CCL5, FAS, SMAD7, GCLC, MMP7, CD82, CYP11A1, MGP, ATG5, CSF2, SPI1, VDR, MFI2, MMP12, CTGF, IL5RA, VCAM1, CSF1, TNC, APOM, IL3, CD69, IL6, MMP13, CSTA, KRT16, MYC2VEGFA, SOD2
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC63VEGFA, IL1RN, SOD2
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC63VEGFA, IL1RN, SOD2
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC14EPO, VEGFA, SOD2, PON1
SP3NO109DNASE2, ATP2A2, VEGFA, ID4, LPL, BPI, CHRNB4, TFF2, CD14, SLC9A3, IGFBP1, CYP27A1, F2R, IGFBP4, CA9, LCAT, CBS, CENPH, NKX2-1, KLK3, EPAS1, HMGA2, CETP, DNMT3A, HSD17B2, FBLN1, YY1, CD2AP, TGM4, FGFR3, SLC1A3, MYCN, CDKN1A, CD97, IGFBP3, ETF1, CDKN2B, GIPR, SOCS3, CYP2F1, FMR1, HGF, FOXP3, TYMP, COL2A1, MUC2, DMRT1, TIMP1, HDAC4, RASSF1, TCN2, CYP3A7, PLAUR, NOX4, CYP17A1, SOX18, PADI3, UBC, TPMT, ABCA1, ALOX12, COL11A2, OPRM1, PLAT, HBEGF, CDKN2A, BSG, MSH6, RORA, NOS3, MUC4, CCND1, SCTR, FBP1, LTC4S, CTSL, BIRC5, AGTR1, MAT2A, TIMP2, CDH2, COL1A1, TFF1, ITGAV, SLC9A2, LOR, BTK, MET, EAPP, SLC19A3, MMP2, CTSB, TRA, KDR, DNMT3B, ITGA2, MICB, ERBB2, ACE, MAOB, SCT, CD83, HOXB7, UTRN, CYP3A5, ITGAD, LECT1, ALPL, MUC62VEGFA, ACE
EP300NO56ALOX15, PCNA, MDM2, VCAM1, EIF2AK1, PTGS2, BIRC5, IFNG, EPO, PARP1, TBXAS1, BGLAP, CDKN2B, IL12B, RS1, LDHA, CCNE1, ABCB1, TP73, KLF5, LAMA3, HINFP, THBD, ERBB2, DNMT1, BRCA1, WT1, CCNB2, CDKN1A, ZEB1, GFAP, TRIM22, SPP1, CYBB, RELA, NPAS2, CXCL8, VEGFA, NFKB1, CRABP1, CA9, NR0B2, NR1H4, CREBBP, CLOCK, IGFBP3, IL5, IL6, SLC9A2, MMP9, IGF1, KRT16, MYC, CCND1, PML, RAD512EPO, VEGFA
ARNTNO20HIF1A, CA9, CCNE1, CDK2, CYP1A2, EGLN2, FOS, TH, JUN, CTSD, EPO, BHLHE40, GAD1, MFSD2A, ESR1, UGT1A6, AHR, CYP1A1, VEGFA, CYP1B12EPO, VEGFA
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
IL1RNYES3STAT3, NFKB1, RELA0
SOD2YES10SP1, XBP1, NFKB1, JUN, NFE2L2, FOXO4, RELA, REL, PPARA, DDB20
ACEYES4SP3, HIF1A, CREM, EGR10
PON1YES2SP1, SREBF20
EPOYES11SP1, GATA3, ARNT, GATA2, NCOA3, SMAD4, NCOA1, SMAD3, EP300, GATA1, HIF1A0
VEGFAYES53ATM, WT1, AR, FOXM1, ID3, ATF4, COPS5, TFAP2A, EPAS1, PGR, RUNX1, SP1, NKX3-1, TEAD4, ARNT, EGR1, EP300, KLF5, MYC, SMAD3, HDGF, HTATIP2, DNMT1, FOXO3, HIPK2, ZFP36, HEXIM1, VHL, ZFP36L1, XBP1, ESR2, NR1H4, HOXB7, JUN, ZNF24, TP53, RELA, HDAC4, RUNX2, NFKB1, BRCA1, FOXQ1, E2F1, STAT3, UHRF1, TCF4, PTTG1, ZNRD1, HIF1A, ESR1, SP3, MEF2C, E2F30
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SOD2ACENo-1SOD3
SOD2PON1No-1IL6
SOD2EPONo-2FOXO3, SIRT1
SOD2VEGFANo-4FOXO3, AKT1, IL6, FOXO1
ACEEPONo-1NOS3
ACEVEGFANo-1NOS3
PON1VEGFANo-3CLU, IL6, PPARG
EPOVEGFANo-22PLCG1, BMP4, SOS1, PDGFB, HIF3A, MAPK8, CREB1, COPS5, SHC1, KIT, ARNT, NOS3, JUN, EPAS1, EP300, FOXO3, EDN1, STAT3, CBL, GRB2, CREBBP, HIF1A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
HIF-1 signaling pathwayhsa040665.92EPO, VEGFA
Cytokine-cytokine receptor interactionhsa040604.672EPO, VEGFA
PI3K-Akt signaling pathwayhsa041514.212EPO, VEGFA
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Cellular responses to stressR-HSA-22627524.563EPO, VEGFA, SOD2
Cellular response to hypoxiaR-HSA-22627498.42EPO, VEGFA
Regulation of gene expression by Hypoxia-inducible FactorR-HSA-12341589.812EPO, VEGFA
Regulation of Hypoxia-inducible Factor (HIF) by oxygenR-HSA-12341748.42EPO, VEGFA

NET-GE enrichment

Term New enriched termICP valueGenes
Cellular response to hypoxia (R-HSA-2262749) -8.40.023EPO, VEGFA
Cellular responses to stress (R-HSA-2262752) -4.560.019EPO, VEGFA, SOD2
Regulation of gene expression by Hypoxia-inducible Factor (R-HSA-1234158) -9.810.0EPO, VEGFA
Regulation of Hypoxia-inducible Factor (HIF) by oxygen (R-HSA-1234174) -8.40.023EPO, VEGFA
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.187IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
protein binding (GO:0005515) 0.467IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
receptor binding (GO:0005102) 2.435EPO, VEGFA, IL1RN, HFE, ACE
cytokine receptor binding (GO:0005126) 4.143EPO, VEGFA, IL1RN
cation binding (GO:0043169) 1.43ACE, SOD2, PON1
molecular function regulator (GO:0098772) 2.513EPO, VEGFA, IL1RN
ion binding (GO:0043167) 1.363ACE, SOD2, PON1
catalytic activity (GO:0003824) 1.053ACE, PON1, SOD2
metal ion binding (GO:0046872) 1.413ACE, PON1, SOD2
identical protein binding (GO:0042802) 2.633VEGFA, PON1, SOD2
hydrolase activity (GO:0016787) 1.92ACE, PON1
cytokine activity (GO:0005125) 4.342VEGFA, IL1RN
transition metal ion binding (GO:0046914) 2.482ACE, SOD2
growth factor receptor binding (GO:0070851) 4.872VEGFA, IL1RN
receptor regulator activity (GO:0030545) 5.912VEGFA, IL1RN
enzyme binding (GO:0019899) 2.272ACE, SOD2
protein dimerization activity (GO:0046983) 2.722VEGFA, PON1
protein homodimerization activity (GO:0042803) 3.162VEGFA, PON1

NET-GE enrichment

Term New enriched termICP valueGenes
cytokine receptor binding (GO:0005126) -4.140.006EPO, VEGFA, IL1RN
endopeptidase activity (GO:0004175) NEW3.630.0IL1RN, PON1, SOD2, HFE, VEGFA, ACE
interleukin-1 receptor binding (GO:0005149) NEW6.850.019VEGFA, IL1RN
growth factor receptor binding (GO:0070851) -4.870.001VEGFA, IL1RN, ACE, SOD2
receptor regulator activity (GO:0030545) -5.910.009VEGFA, IL1RN
alcohol binding (GO:0043178) NEW5.530.039VEGFA, SOD2, PON1
interleukin-1, Type II receptor binding (GO:0005151) NEW9.050.0VEGFA, IL1RN
carboxylic ester hydrolase activity (GO:0052689) NEW4.810.029VEGFA, PON1, SOD2
peptidase activity, acting on L-amino acid peptides (GO:0070011) NEW3.260.002IL1RN, PON1, SOD2, HFE, VEGFA, ACE
glycosaminoglycan binding (GO:0005539) NEW4.420.016VEGFA, IL1RN, ACE, SOD2
exopeptidase activity (GO:0008238) NEW5.070.032VEGFA, ACE, SOD2
peptidase activity (GO:0008233) NEW3.230.002IL1RN, PON1, SOD2, HFE, VEGFA, ACE
receptor binding (GO:0005102) -2.430.003EPO, VEGFA, IL1RN, ACE, HFE
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.267IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
regulation of cellular process (GO:0050794) 0.57IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
biological regulation (GO:0065007) 0.397IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
single-organism cellular process (GO:0044763) 0.657IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
negative regulation of cellular process (GO:0048523) 1.417IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
negative regulation of biological process (GO:0048519) 1.337IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
regulation of biological process (GO:0050789) 0.457IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
single-organism process (GO:0044699) 0.487IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
regulation of metabolic process (GO:0019222) 1.026PON1, EPO, SOD2, HFE, VEGFA, ACE
regulation of macromolecule metabolic process (GO:0060255) 1.086PON1, EPO, SOD2, HFE, VEGFA, ACE
response to stimulus (GO:0050896) 1.226IL1RN, PON1, EPO, HFE, VEGFA, SOD2
regulation of cellular metabolic process (GO:0031323) 1.076PON1, EPO, SOD2, HFE, VEGFA, ACE
metabolic process (GO:0008152) 0.586IL1RN, PON1, EPO, SOD2, HFE, ACE
positive regulation of biological process (GO:0048518) 1.26PON1, EPO, SOD2, HFE, VEGFA, ACE
response to chemical (GO:0042221) 1.986IL1RN, PON1, EPO, HFE, VEGFA, SOD2
regulation of molecular function (GO:0065009) 1.786PON1, EPO, SOD2, HFE, VEGFA, ACE
regulation of biological quality (GO:0065008) 1.686IL1RN, EPO, SOD2, HFE, VEGFA, ACE
developmental process (GO:0032502) 1.365EPO, ACE, VEGFA, HFE, SOD2
regulation of cell communication (GO:0010646) 1.735EPO, VEGFA, IL1RN, HFE, SOD2
positive regulation of metabolic process (GO:0009893) 1.745EPO, ACE, VEGFA, HFE, SOD2
regulation of primary metabolic process (GO:0080090) 1.085EPO, VEGFA, ACE, SOD2, HFE
regulation of signal transduction (GO:0009966) 1.845EPO, VEGFA, IL1RN, HFE, SOD2
positive regulation of cellular metabolic process (GO:0031325) 1.815EPO, VEGFA, ACE, SOD2, HFE
regulation of response to stimulus (GO:0048583) 1.545EPO, VEGFA, IL1RN, HFE, SOD2
single-organism developmental process (GO:0044767) 1.495EPO, ACE, VEGFA, HFE, SOD2
organic substance metabolic process (GO:0071704) 0.635EPO, ACE, IL1RN, PON1, SOD2
response to stress (GO:0006950) 1.85EPO, VEGFA, IL1RN, HFE, SOD2
regulation of multicellular organismal process (GO:0051239) 1.875EPO, VEGFA, IL1RN, ACE, HFE
positive regulation of molecular function (GO:0044093) 2.235EPO, VEGFA, ACE, PON1, HFE
regulation of signaling (GO:0023051) 1.725EPO, VEGFA, IL1RN, HFE, SOD2
regulation of localization (GO:0032879) 1.945EPO, VEGFA, ACE, PON1, HFE
response to organic substance (GO:0010033) 2.25EPO, VEGFA, IL1RN, PON1, SOD2
multicellular organismal process (GO:0032501) 1.455EPO, ACE, VEGFA, HFE, SOD2
positive regulation of cellular process (GO:0048522) 1.35EPO, ACE, VEGFA, HFE, SOD2
response to extracellular stimulus (GO:0009991) 3.714EPO, PON1, SOD2, HFE
positive regulation of protein modification process (GO:0031401) 2.74EPO, VEGFA, ACE, HFE
negative regulation of metabolic process (GO:0009892) 1.934EPO, VEGFA, HFE, PON1
regulation of protein metabolic process (GO:0051246) 1.934EPO, VEGFA, ACE, HFE
regulation of transport (GO:0051049) 2.244EPO, VEGFA, PON1, HFE
negative regulation of response to stimulus (GO:0048585) 2.524EPO, IL1RN, HFE, SOD2
cell differentiation (GO:0030154) 2.144EPO, VEGFA, ACE, SOD2
negative regulation of cellular metabolic process (GO:0031324) 2.014EPO, VEGFA, HFE, PON1
regulation of cellular biosynthetic process (GO:0031326) 1.384EPO, VEGFA, HFE, SOD2
regulation of cellular component organization (GO:0051128) 2.014EPO, VEGFA, ACE, HFE
circulatory system process (GO:0003013) 4.384EPO, VEGFA, ACE, SOD2
signal transduction (GO:0007165) 1.284EPO, VEGFA, HFE, SOD2
regulation of phosphate metabolic process (GO:0019220) 2.354EPO, VEGFA, HFE, ACE
single-organism metabolic process (GO:0044710) 1.634ACE, IL1RN, PON1, SOD2
negative regulation of macromolecule metabolic process (GO:0010605) 2.014EPO, VEGFA, PON1, HFE
positive regulation of macromolecule metabolic process (GO:0010604) 1.814EPO, VEGFA, ACE, HFE
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.244EPO, VEGFA, HFE, SOD2
cellular developmental process (GO:0048869) 1.824EPO, VEGFA, ACE, SOD2
positive regulation of phosphorus metabolic process (GO:0010562) 2.784EPO, VEGFA, HFE, ACE
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464EPO, VEGFA, HFE, SOD2
positive regulation of protein metabolic process (GO:0051247) 2.434EPO, VEGFA, ACE, HFE
regulation of developmental process (GO:0050793) 2.14EPO, VEGFA, IL1RN, ACE
animal organ development (GO:0048513) 2.534ACE, VEGFA, HFE, SOD2
regulation of immune system process (GO:0002682) 2.54EPO, VEGFA, ACE, HFE
regulation of protein modification process (GO:0031399) 2.324EPO, VEGFA, ACE, HFE
positive regulation of cellular protein metabolic process (GO:0032270) 2.494EPO, VEGFA, ACE, HFE
regulation of cell adhesion (GO:0030155) 3.274EPO, VEGFA, IL1RN, HFE
regulation of cell proliferation (GO:0042127) 2.414EPO, VEGFA, ACE, SOD2
transport (GO:0006810) 1.514VEGFA, IL1RN, ACE, HFE
positive regulation of phosphate metabolic process (GO:0045937) 2.784EPO, VEGFA, ACE, HFE
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434EPO, VEGFA, HFE, SOD2
regulation of catalytic activity (GO:0050790) 1.974EPO, VEGFA, ACE, SOD2
regulation of biosynthetic process (GO:0009889) 1.374EPO, VEGFA, HFE, SOD2
cellular response to stimulus (GO:0051716) 1.974EPO, VEGFA, HFE, SOD2
regulation of nucleic acid-templated transcription (GO:1903506) 1.554EPO, VEGFA, HFE, SOD2
regulation of phosphorus metabolic process (GO:0051174) 2.354EPO, VEGFA, HFE, ACE
reproductive process (GO:0022414) 2.554EPO, VEGFA, HFE, ACE
regulation of nitrogen compound metabolic process (GO:0051171) 1.364EPO, VEGFA, HFE, SOD2
regulation of RNA biosynthetic process (GO:2001141) 1.554EPO, VEGFA, HFE, SOD2
establishment of localization (GO:0051234) 1.484VEGFA, IL1RN, ACE, HFE
localization (GO:0051179) 1.44VEGFA, IL1RN, ACE, HFE
system process (GO:0003008) 2.34EPO, VEGFA, ACE, SOD2
regulation of phosphorylation (GO:0042325) 2.54EPO, VEGFA, ACE, HFE
primary metabolic process (GO:0044238) 0.694EPO, IL1RN, ACE, PON1
positive regulation of phosphorylation (GO:0042327) 2.94EPO, VEGFA, ACE, HFE
regulation of cellular protein metabolic process (GO:0032268) 1.994EPO, VEGFA, ACE, HFE
single-multicellular organism process (GO:0044707) 1.784ACE, VEGFA, HFE, SOD2
response to external stimulus (GO:0009605) 2.554EPO, PON1, SOD2, HFE
anatomical structure development (GO:0048856) 1.584VEGFA, ACE, SOD2, HFE
response to nutrient levels (GO:0031667) 3.774EPO, PON1, SOD2, HFE
cellular metabolic process (GO:0044237) 0.694EPO, ACE, PON1, SOD2
regulation of gene expression (GO:0010468) 1.374EPO, VEGFA, HFE, SOD2
immune system process (GO:0002376) 2.294VEGFA, IL1RN, HFE, ACE
regulation of transcription, DNA-templated (GO:0006355) 1.564EPO, VEGFA, HFE, SOD2
regulation of macromolecule biosynthetic process (GO:0010556) 1.434EPO, VEGFA, HFE, SOD2
regulation of multicellular organismal development (GO:2000026) 2.314EPO, VEGFA, IL1RN, ACE
cellular response to stress (GO:0033554) 2.514EPO, VEGFA, HFE, SOD2
response to lipid (GO:0033993) 3.114EPO, IL1RN, PON1, SOD2
regulation of protein phosphorylation (GO:0001932) 2.574EPO, VEGFA, ACE, HFE
regulation of RNA metabolic process (GO:0051252) 1.524EPO, VEGFA, HFE, SOD2
positive regulation of protein phosphorylation (GO:0001934) 2.954EPO, VEGFA, ACE, HFE
regulation of kinase activity (GO:0043549) 3.073EPO, VEGFA, ACE
regulation of cellular localization (GO:0060341) 3.033EPO, VEGFA, HFE
positive regulation of biosynthetic process (GO:0009891) 2.293EPO, VEGFA, SOD2
positive regulation of response to stimulus (GO:0048584) 2.183EPO, VEGFA, HFE
positive regulation of signaling (GO:0023056) 2.413EPO, VEGFA, HFE
negative regulation of signaling (GO:0023057) 2.653EPO, IL1RN, SOD2
nitrogen compound metabolic process (GO:0006807) 1.133ACE, SOD2, PON1
positive regulation of cellular biosynthetic process (GO:0031328) 2.33EPO, VEGFA, SOD2
negative regulation of cell communication (GO:0010648) 2.663EPO, IL1RN, SOD2
cellular response to chemical stimulus (GO:0070887) 2.573VEGFA, HFE, SOD2
vascular process in circulatory system (GO:0003018) 4.653VEGFA, ACE, SOD2
positive regulation of cell communication (GO:0010647) 2.413EPO, VEGFA, HFE
response to hypoxia (GO:0001666) 4.133EPO, VEGFA, SOD2
regulation of apoptotic process (GO:0042981) 2.53EPO, VEGFA, SOD2
positive regulation of catalytic activity (GO:0043085) 2.43EPO, VEGFA, ACE
regulation of intracellular signal transduction (GO:1902531) 2.313EPO, VEGFA, SOD2
positive regulation of transferase activity (GO:0051347) 3.313EPO, VEGFA, ACE
negative regulation of signal transduction (GO:0009968) 2.753EPO, IL1RN, SOD2
positive regulation of signal transduction (GO:0009967) 2.53EPO, VEGFA, HFE
positive regulation of kinase activity (GO:0033674) 3.543EPO, VEGFA, ACE
regulation of programmed cell death (GO:0043067) 2.493EPO, VEGFA, SOD2
negative regulation of apoptotic process (GO:0043066) 3.043EPO, VEGFA, SOD2
negative regulation of molecular function (GO:0044092) 2.743EPO, VEGFA, HFE
negative regulation of programmed cell death (GO:0043069) 3.023EPO, VEGFA, SOD2
positive regulation of cellular component organization (GO:0051130) 2.683EPO, VEGFA, HFE
positive regulation of transport (GO:0051050) 2.93VEGFA, HFE, PON1
negative regulation of cell death (GO:0060548) 2.953EPO, VEGFA, SOD2
regulation of protein kinase activity (GO:0045859) 3.153EPO, VEGFA, ACE
regulation of hormone levels (GO:0010817) 3.563IL1RN, ACE, HFE
defense response (GO:0006952) 2.783EPO, IL1RN, HFE
acute-phase response (GO:0006953) 5.943EPO, IL1RN, HFE
single-organism transport (GO:0044765) 2.183VEGFA, IL1RN, ACE
inflammatory response (GO:0006954) 3.643EPO, IL1RN, HFE
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293EPO, VEGFA, SOD2
acute inflammatory response (GO:0002526) 5.483EPO, IL1RN, HFE
response to inorganic substance (GO:0010035) 3.563PON1, SOD2, HFE
response to abiotic stimulus (GO:0009628) 2.83EPO, VEGFA, SOD2
single-organism localization (GO:1902578) 2.093VEGFA, IL1RN, ACE
response to oxygen levels (GO:0070482) 4.023EPO, VEGFA, SOD2
response to oxygen-containing compound (GO:1901700) 2.573EPO, SOD2, PON1
homeostatic process (GO:0042592) 2.613VEGFA, HFE, SOD2
secretion (GO:0046903) 3.383VEGFA, IL1RN, ACE
single organism reproductive process (GO:0044702) 2.733EPO, VEGFA, ACE
regulation of cell-cell adhesion (GO:0022407) 3.793EPO, IL1RN, HFE
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 4.623EPO, VEGFA, ACE
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.353EPO, VEGFA, ACE
regulation of response to stress (GO:0080134) 2.533EPO, VEGFA, SOD2
regulation of cellular response to stress (GO:0080135) 3.43EPO, VEGFA, SOD2
regulation of cell death (GO:0010941) 2.433EPO, VEGFA, SOD2
biosynthetic process (GO:0009058) 1.323EPO, HFE, SOD2
regulation of transferase activity (GO:0051338) 2.883EPO, VEGFA, ACE
chemical homeostasis (GO:0048878) 2.973VEGFA, HFE, SOD2
regulation of cell differentiation (GO:0045595) 2.423EPO, VEGFA, SOD2
positive regulation of gene expression (GO:0010628) 2.353EPO, VEGFA, HFE
response to decreased oxygen levels (GO:0036293) 4.093EPO, VEGFA, SOD2
positive regulation of protein kinase activity (GO:0045860) 3.613EPO, VEGFA, ACE
negative regulation of apoptotic signaling pathway (GO:2001234) 4.422EPO, SOD2
regulation of intrinsic apoptotic signaling pathway (GO:2001242) 4.742EPO, SOD2
regulation of neuron projection development (GO:0010975) 3.692EPO, VEGFA
regulation of apoptotic signaling pathway (GO:2001233) 3.832EPO, SOD2
cell development (GO:0048468) 3.282VEGFA, SOD2
cell maturation (GO:0048469) 4.982EPO, VEGFA
negative regulation of cell adhesion (GO:0007162) 4.332IL1RN, HFE
iron ion homeostasis (GO:0055072) 5.492SOD2, HFE
cell surface receptor signaling pathway (GO:0007166) 2.092VEGFA, HFE
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242VEGFA, HFE
inorganic ion homeostasis (GO:0098771) 3.432SOD2, HFE
positive regulation of receptor-mediated endocytosis (GO:0048260) 5.842VEGFA, HFE
activation of protein kinase activity (GO:0032147) 4.082EPO, VEGFA
regulation of cell projection organization (GO:0031344) 3.382EPO, VEGFA
cellular component organization or biogenesis (GO:0071840) 1.222HFE, SOD2
positive regulation of cell projection organization (GO:0031346) 3.992EPO, VEGFA
single-organism catabolic process (GO:0044712) 3.212ACE, PON1
hormone metabolic process (GO:0042445) 4.642ACE, HFE
response to external biotic stimulus (GO:0043207) 3.132EPO, SOD2
positive regulation of cell adhesion (GO:0045785) 3.792EPO, VEGFA
kidney development (GO:0001822) 4.792VEGFA, ACE
regulation of neuron differentiation (GO:0045664) 3.392EPO, VEGFA
positive regulation of neuron differentiation (GO:0045666) 3.982EPO, VEGFA
positive regulation of cell development (GO:0010720) 3.572EPO, VEGFA
regulation of cell junction assembly (GO:1901888) 5.492VEGFA, ACE
erythrocyte differentiation (GO:0030218) 5.882EPO, VEGFA
response to axon injury (GO:0048678) 5.862EPO, SOD2
regulation of proteolysis (GO:0030162) 3.22VEGFA, HFE
positive regulation of neuron projection development (GO:0010976) 4.262EPO, VEGFA
response to metal ion (GO:0010038) 3.912SOD2, HFE
organonitrogen compound metabolic process (GO:1901564) 2.322ACE, SOD2
cellular catabolic process (GO:0044248) 2.622ACE, PON1
response to biotic stimulus (GO:0009607) 3.092EPO, SOD2
protein metabolic process (GO:0019538) 1.452EPO, ACE
regulation of STAT cascade (GO:1904892) 4.782EPO, VEGFA
negative regulation of gene expression (GO:0010629) 2.482EPO, VEGFA
negative regulation of cellular biosynthetic process (GO:0031327) 2.492EPO, VEGFA
positive regulation of binding (GO:0051099) 4.882PON1, HFE
cellular component assembly (GO:0022607) 2.142SOD2, HFE
negative regulation of biosynthetic process (GO:0009890) 2.472EPO, VEGFA
regulation of anatomical structure morphogenesis (GO:0022603) 2.792VEGFA, IL1RN
positive regulation of protein autophosphorylation (GO:0031954) 6.732VEGFA, ACE
transition metal ion homeostasis (GO:0055076) 5.092HFE, SOD2
regulation of protein autophosphorylation (GO:0031952) 6.172VEGFA, ACE
secretion by cell (GO:0032940) 3.592VEGFA, IL1RN
antigen processing and presentation of peptide antigen (GO:0048002) 4.562ACE, HFE
response to lipopolysaccharide (GO:0032496) 4.032EPO, SOD2
regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418) 6.262EPO, VEGFA
positive regulation of JAK-STAT cascade (GO:0046427) 5.442EPO, VEGFA
organic substance catabolic process (GO:1901575) 2.452ACE, PON1
cellular component organization (GO:0016043) 1.242HFE, SOD2
regulation of anatomical structure size (GO:0090066) 3.782ACE, SOD2
macromolecular complex assembly (GO:0065003) 2.552SOD2, HFE
positive regulation of immune system process (GO:0002684) 2.962EPO, VEGFA
regulation of protein localization (GO:0032880) 2.882VEGFA, HFE
regulation of tube size (GO:0035150) 4.792ACE, SOD2
antigen processing and presentation (GO:0019882) 4.362ACE, HFE
lipid metabolic process (GO:0006629) 2.682IL1RN, PON1
ion transport (GO:0006811) 2.662ACE, HFE
positive regulation of MAPK cascade (GO:0043410) 3.572EPO, VEGFA
regulation of blood vessel size (GO:0050880) 4.82ACE, SOD2
immune response (GO:0006955) 2.862IL1RN, HFE
negative regulation of intracellular signal transduction (GO:1902532) 3.632EPO, SOD2
positive regulation of intracellular signal transduction (GO:1902533) 2.952EPO, VEGFA
regulation of neuron death (GO:1901214) 4.192EPO, SOD2
negative regulation of neuron death (GO:1901215) 4.572EPO, SOD2
negative regulation of proteolysis (GO:0045861) 3.982VEGFA, HFE
response to electrical stimulus (GO:0051602) 5.92EPO, SOD2
negative regulation of RNA biosynthetic process (GO:1902679) 2.72EPO, VEGFA
response to increased oxygen levels (GO:0036296) 6.42EPO, SOD2
regulation of leukocyte activation (GO:0002694) 3.62EPO, HFE
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392EPO, VEGFA
regulation of nervous system development (GO:0051960) 3.12EPO, VEGFA
regulation of cell motility (GO:2000145) 3.162VEGFA, ACE
peptide metabolic process (GO:0006518) 3.442ACE, SOD2
response to wounding (GO:0009611) 4.392EPO, SOD2
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532EPO, VEGFA
ion homeostasis (GO:0050801) 3.422SOD2, HFE
positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531) 5.632EPO, VEGFA
regulation of cellular protein localization (GO:1903827) 3.432VEGFA, HFE
cellular biosynthetic process (GO:0044249) 1.372EPO, SOD2
cellular nitrogen compound metabolic process (GO:0034641) 1.222ACE, SOD2
regulation of transcription from RNA polymerase II promoter in response to stress (GO:0043618) 5.62EPO, VEGFA
regulation of receptor-mediated endocytosis (GO:0048259) 5.352VEGFA, HFE
response to organic cyclic compound (GO:0014070) 3.072EPO, IL1RN
regulation of MAPK cascade (GO:0043408) 3.222EPO, VEGFA
regulation of neurogenesis (GO:0050767) 3.212EPO, VEGFA
negative regulation of protein metabolic process (GO:0051248) 2.822VEGFA, HFE
regulation of lymphocyte activation (GO:0051249) 3.732EPO, HFE
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122EPO, VEGFA
catabolic process (GO:0009056) 2.382ACE, PON1
positive regulation of multicellular organismal process (GO:0051240) 2.492EPO, VEGFA
regulation of cell development (GO:0060284) 3.012EPO, VEGFA
positive regulation of neurogenesis (GO:0050769) 3.772EPO, VEGFA
regulation of cell activation (GO:0050865) 3.532EPO, HFE
regulation of transporter activity (GO:0032409) 4.452EPO, PON1
response to vitamin (GO:0033273) 5.112EPO, SOD2
regulation of stem cell proliferation (GO:0072091) 5.62VEGFA, ACE
negative regulation of intrinsic apoptotic signaling pathway (GO:2001243) 5.212EPO, SOD2
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.012EPO, HFE
positive regulation of cell proliferation (GO:0008284) 3.012EPO, VEGFA
regulation of vesicle-mediated transport (GO:0060627) 3.632VEGFA, HFE
positive regulation of cell differentiation (GO:0045597) 3.012EPO, VEGFA
regulation of locomotion (GO:0040012) 3.122VEGFA, ACE
negative regulation of transcription, DNA-templated (GO:0045892) 2.752EPO, VEGFA
positive regulation of transcription, DNA-templated (GO:0045893) 2.562EPO, VEGFA
cation homeostasis (GO:0055080) 3.462HFE, SOD2
negative regulation of cellular protein metabolic process (GO:0032269) 2.882VEGFA, HFE
aging (GO:0007568) 4.162EPO, SOD2
cellular amide metabolic process (GO:0043603) 3.232ACE, SOD2
positive regulation of developmental process (GO:0051094) 2.772EPO, VEGFA
negative regulation of RNA metabolic process (GO:0051253) 2.662EPO, VEGFA
regulation of binding (GO:0051098) 4.082HFE, PON1
positive regulation of RNA metabolic process (GO:0051254) 2.512EPO, VEGFA
macromolecule metabolic process (GO:0043170) 0.832EPO, ACE
positive regulation of RNA biosynthetic process (GO:1902680) 2.542EPO, VEGFA
response to molecule of bacterial origin (GO:0002237) 3.992EPO, SOD2
myeloid cell differentiation (GO:0030099) 4.632EPO, VEGFA
liver development (GO:0001889) 4.982SOD2, HFE
gland development (GO:0048732) 4.152HFE, SOD2
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562EPO, VEGFA
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232EPO, VEGFA
positive regulation of STAT cascade (GO:1904894) 5.442EPO, VEGFA
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562EPO, VEGFA
macromolecular complex subunit organization (GO:0043933) 2.142SOD2, HFE
response to transition metal nanoparticle (GO:1990267) 4.72HFE, SOD2
regulation of T cell activation (GO:0050863) 4.052EPO, HFE
regulation of blood pressure (GO:0008217) 4.722ACE, SOD2
response to hyperoxia (GO:0055093) 6.42EPO, SOD2
negative regulation of cell-cell adhesion (GO:0022408) 4.842IL1RN, HFE
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) 5.192ACE, HFE
protein complex subunit organization (GO:0071822) 2.62HFE, SOD2
positive regulation of nervous system development (GO:0051962) 3.642EPO, VEGFA
developmental maturation (GO:0021700) 4.72EPO, VEGFA
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62EPO, VEGFA
cellular response to organic substance (GO:0071310) 2.782VEGFA, SOD2
regulation of ion transport (GO:0043269) 3.42EPO, HFE
organic substance transport (GO:0071702) 2.152IL1RN, ACE
regulation of peptidyl-tyrosine autophosphorylation (GO:1900084) 8.342VEGFA, ACE
positive regulation of peptidyl-tyrosine autophosphorylation (GO:1900086) 8.632VEGFA, ACE
neuron development (GO:0048666) 4.82VEGFA, SOD2
regulation of cell migration (GO:0030334) 3.232VEGFA, ACE
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352EPO, VEGFA
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552EPO, VEGFA
regulation of JAK-STAT cascade (GO:0046425) 4.782EPO, VEGFA
response to nutrient (GO:0007584) 4.492EPO, SOD2
protein complex assembly (GO:0006461) 2.782HFE, SOD2
regulation of metal ion transport (GO:0010959) 3.942EPO, HFE
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472EPO, VEGFA
metal ion homeostasis (GO:0055065) 3.612SOD2, HFE
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712EPO, VEGFA
regulation of endocytosis (GO:0030100) 4.422VEGFA, HFE
regulation of DNA-templated transcription in response to stress (GO:0043620) 5.522EPO, VEGFA
regulation of tyrosine phosphorylation of STAT protein (GO:0042509) 5.492EPO, VEGFA
regulation of cellular component movement (GO:0051270) 3.082VEGFA, ACE
regulation of cellular component biogenesis (GO:0044087) 3.082VEGFA, ACE
phosphate-containing compound metabolic process (GO:0006796) 2.162EPO, PON1
phosphorus metabolic process (GO:0006793) 2.152EPO, PON1
positive regulation of endocytosis (GO:0045807) 4.982VEGFA, HFE
response to acid chemical (GO:0001101) 4.052PON1, SOD2

NET-GE enrichment

Term New enriched termICP valueGenes
negative regulation of apoptotic signaling pathway (GO:2001234) -4.420.026EPO, VEGFA, SOD2
negative regulation of heterotypic cell-cell adhesion (GO:0034115) NEW7.780.031VEGFA, IL1RN
cell proliferation in hindbrain (GO:0021534) NEW7.780.019VEGFA, ACE
response to L-ascorbic acid (GO:0033591) NEW7.780.012VEGFA, SOD2
response to axon injury (GO:0048678) -5.860.025EPO, VEGFA, SOD2
negative regulation of homeostatic process (GO:0032845) NEW4.910.049EPO, VEGFA
response to reactive oxygen species (GO:0000302) NEW4.50.028EPO, VEGFA, ACE, SOD2
circulatory system process (GO:0003013) -4.380.01EPO, VEGFA, SOD2
response to lipopolysaccharide (GO:0032496) -4.030.005EPO, VEGFA, IL1RN, ACE, SOD2
regulation of transcription from RNA polymerase II promoter in response to hypoxia (GO:0061418) -6.260.043EPO, VEGFA
response to external biotic stimulus (GO:0043207) -3.130.018IL1RN, EPO, SOD2, HFE, VEGFA, ACE
response to hyperoxia (GO:0055093) -6.40.017EPO, SOD2
lipid transport (GO:0006869) NEW4.240.046ACE, VEGFA, SOD2, PON1
regulation of transporter activity (GO:0032409) -4.450.041EPO, VEGFA, PON1, SOD2
negative regulation of calcium ion transport into cytosol (GO:0010523) NEW6.90.019EPO, VEGFA
regulation of hormone levels (GO:0010817) -3.560.008VEGFA, IL1RN, ACE, SOD2, HFE
cellular response to oxidative stress (GO:0034599) NEW4.70.023EPO, VEGFA, ACE, SOD2
phosphatidylinositol-mediated signaling (GO:0048015) NEW4.930.007EPO, VEGFA, ACE, SOD2
response to oxidative stress (GO:0006979) NEW3.90.017EPO, ACE, VEGFA, HFE, SOD2
inositol lipid-mediated signaling (GO:0048017) NEW4.910.007EPO, VEGFA, ACE, SOD2
system process (GO:0003008) -2.30.015EPO, VEGFA, IL1RN, ACE, SOD2
response to electrical stimulus (GO:0051602) -5.90.046EPO, VEGFA, SOD2
regulation of cell-cell adhesion involved in gastrulation (GO:0070587) NEW7.780.031VEGFA, IL1RN
response to biotic stimulus (GO:0009607) -3.090.027IL1RN, EPO, SOD2, HFE, VEGFA, ACE
response to external stimulus (GO:0009605) -2.550.001IL1RN, PON1, EPO, HFE, VEGFA, SOD2
multicellular organismal homeostasis (GO:0048871) NEW5.070.024VEGFA, IL1RN, HFE
multi-multicellular organism process (GO:0044706) NEW4.920.031EPO, VEGFA, IL1RN, HFE
regulation of cellular response to stress (GO:0080135) -3.40.006EPO, VEGFA, IL1RN, SOD2
response to increased oxygen levels (GO:0036296) -6.40.017EPO, SOD2
response to molecule of bacterial origin (GO:0002237) -3.990.007EPO, VEGFA, IL1RN, ACE, SOD2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.117IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
extracellular region part (GO:0044421) 1.577IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
intracellular part (GO:0044424) 0.286IL1RN, PON1, SOD2, HFE, VEGFA, ACE
extracellular space (GO:0005615) 2.636IL1RN, PON1, EPO, HFE, VEGFA, ACE
membrane-bounded organelle (GO:0043227) 0.476IL1RN, PON1, SOD2, HFE, VEGFA, ACE
vesicle (GO:0031982) 1.646IL1RN, PON1, SOD2, HFE, VEGFA, ACE
organelle (GO:0043226) 0.46IL1RN, PON1, SOD2, HFE, VEGFA, ACE
extracellular region (GO:0005576) 2.185EPO, VEGFA, IL1RN, ACE, PON1
intracellular organelle (GO:0043229) 0.515ACE, VEGFA, PON1, SOD2, HFE
membrane (GO:0016020) 0.685VEGFA, IL1RN, ACE, SOD2, HFE
intracellular membrane-bounded organelle (GO:0043231) 0.65ACE, VEGFA, SOD2, PON1, HFE
membrane-bounded vesicle (GO:0031988) 1.715ACE, VEGFA, IL1RN, PON1, SOD2
cytoplasm (GO:0005737) 1.014VEGFA, IL1RN, ACE, SOD2
cytoplasmic part (GO:0044444) 0.824ACE, VEGFA, SOD2, HFE
extracellular vesicle (GO:1903561) 1.894ACE, IL1RN, PON1, SOD2
extracellular organelle (GO:0043230) 1.894ACE, IL1RN, PON1, SOD2
extracellular exosome (GO:0070062) 1.894ACE, IL1RN, SOD2, PON1
intracellular organelle part (GO:0044446) 0.813VEGFA, HFE, SOD2
organelle part (GO:0044422) 0.793VEGFA, HFE, SOD2
plasma membrane (GO:0005886) 1.393IL1RN, ACE, HFE
endosome (GO:0005768) 3.252ACE, HFE
external side of plasma membrane (GO:0009897) 4.462ACE, HFE
macromolecular complex (GO:0032991) 1.352PON1, HFE
intracellular non-membrane-bounded organelle (GO:0043232) 1.762HFE, SOD2
organelle lumen (GO:0043233) 3.052VEGFA, SOD2
vacuole (GO:0005773) 2.922ACE, HFE
cytoplasmic vesicle (GO:0031410) 2.872VEGFA, HFE
integral component of membrane (GO:0016021) 1.142ACE, HFE
membrane-enclosed lumen (GO:0031974) 3.052VEGFA, SOD2
intracellular organelle lumen (GO:0070013) 3.052VEGFA, SOD2
non-membrane-bounded organelle (GO:0043228) 1.762SOD2, HFE
intracellular vesicle (GO:0097708) 2.862VEGFA, HFE
side of membrane (GO:0098552) 4.222ACE, HFE
membrane part (GO:0044425) 0.952ACE, HFE
plasma membrane part (GO:0044459) 1.952ACE, HFE
cell surface (GO:0009986) 3.442EPO, VEGFA
intrinsic component of membrane (GO:0031224) 1.132ACE, HFE

NET-GE enrichment

Term New enriched termICP valueGenes
vesicle (GO:0031982) -1.640.01IL1RN, PON1, SOD2, HFE, VEGFA, ACE
extracellular region (GO:0005576) -2.180.003IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE
organelle lumen (GO:0043233) -3.050.049EPO, ACE, VEGFA, HFE, SOD2
extracellular region part (GO:0044421) -1.570.02IL1RN, PON1, EPO, SOD2, VEGFA, ACE
extracellular space (GO:0005615) -2.630.001IL1RN, PON1, EPO, SOD2, HFE, VEGFA, ACE