Disease table of GASTRIC CANCER, HEREDITARY DIFFUSE OMIM ID: 137215

Gene-disease associations table

Gene	Associated with GASTRIC CANCER, HEREDITARY DIFFUSE in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
CDH1	ClinVar, OMIM, HUMSAVAR	HGNC link	16q22.1	5	608089, 167000, 176807, 137215, 114480
IL1RN	OMIM	HGNC link	2q14.1	3	PS603933, 137215, 612852
IL1B	OMIM	HGNC link	2q14.1	2	608316, 137215
KRAS	OMIM	HGNC link	12p12.1	14	601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
2q14.1	2	IL1B, IL1RN

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
2q14	2	IL1B, IL1RN

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
2q1	2	IL1B, IL1RN

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
2q	2	IL1B, IL1RN

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
2	2	IL1B, IL1RN

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	2	IL1RN, CDH1
KLF4	NO	30	ATF3, IVL, GDF15, KRT19, BIRC5, TP53, MMP2, BDKRB2, IFITM3, GPA33, CCND1, LAMA3, THBD, ALPI, IL1B, CDKN1A, VDR, CDH1, RARA, NANOG, HDC, LXN, CYP1A1, HSPA8, CDKN1C, IL6, CDKN1B, CCNB1, ODC1, CDH5	2	IL1B, CDH1
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	3	IL1RN, IL1B, CDH1
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	3	IL1RN, IL1B, CDH1
SIRT1	NO	43	ACAN, TBX3, ESRRG, EZH2, CFLAR, NR1I2, FOXO3, SELE, HSF1, ABCB1, TP73, CCND1, NR5A2, CFH, HYOU1, IL1B, SHC1, COL1A2, NBN, CDKN1A, CTNNB1, MCL1, TNFRSF10B, BCL11A, CDH1, PARP1, ICAM1, PAX6, DLL4, SIRT6, NOTCH1, WRN, ADAMTS5, NDRG1, PER1, TNF, MMP9, COL10A1, TP53, EGLN1, MYC, PPARG, HIF1A	2	IL1B, CDH1
HMGA1	NO	17	PTGS2, SP1, CXCL1, XPA, POU1F1, INSR, CRYAB, CDC25A, TWIST1, IL1B, CDH1, CD44, TP53, RAG2, SLC2A3, BRCA1, KL	2	IL1B, CDH1

regulated gene	associated to this disease	# TFs	TFs
CDH1	YES	49	AR, MTA2, FOXM1, ZEB2, SNAI1, TWIST2, TWIST1, EZH2, RBBP7, FOXA2, TCF3, LMO2, SPDEF, YBX1, KLF4, MTA1, LCOR, HDAC3, DNMT1, FOXQ1, HOXA7, TCF12, ESR1, SIRT1, WT1, ZEB1, FOSB, SMARCA4, VDR, HDAC1, TFAP2A, RELA, PARP1, HMGA2, NFKB1, KLF8, HDGF, STAT3, GATA3, HDAC2, SNAI2, CBX7, SALL4, RB1, HMGA1, KLF6, ZNF217, SIX1, HIF1A
IL1RN	YES	3	STAT3, NFKB1, RELA
IL1B	YES	18	SUGP1, SPI1, HSF1, IRF8, KLF4, REL, NFIL3, NFKBIA, CEBPB, JUN, HMGA1, SIRT1, RELA, AHR, JUNB, NFKB1, E2F1, STAT1
KRAS	YES	1	MYC

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
CDH1	IL1B	No	1	FYN
IL1RN	IL1B	No	1	IL1R1
IL1B	KRAS	No	2	ELAVL1, APP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
CDH1	IL1B	No	-	24	CTGF, IL8, MMP9, BMP7, FGF2, FOS, PTGS2, IL4, NFKB1, SMAD7, PIK3CA, CD44, LEP, STAT3, PSEN1, JUN, CDH2, EP300, IL24, ITGA6, FGF13, IGF1R, PIK3R1, PPARG
CDH1	KRAS	No	-	31	AKT1, BMP4, MAPK3, RET, TP53, EGFR, CTGF, IGF2BP1, BCL2, CCND1, PIK3CA, EPHA2, ERBB2, ERBB3, KIT, IRS2, SLC3A2, PRMT5, UBC, RPS6KB1, IL8, ABL1, SRC, FYN, YES1, NOTCH1, MAPK1, JUN, CDX1, CDX2, EGF
IL1B	KRAS	No	-	10	MAPK11, LGALS3, PIK3CA, JUN, GAST, IL8, CTGF, MAP3K3, VEGFA, MAPK14

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Melanoma	hsa05218	6.56	2	KRAS, CDH1
Bladder cancer	hsa05219	7.38	2	KRAS, CDH1
Endometrial cancer	hsa05213	6.81	2	KRAS, CDH1
Thyroid cancer	hsa05216	7.48	2	KRAS, CDH1
Pathways in cancer	hsa05200	3.98	2	KRAS, CDH1
Rap1 signaling pathway	hsa04015	4.97	2	KRAS, CDH1
MAPK signaling pathway	hsa04010	4.63	2	KRAS, IL1B

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Melanoma (hsa05218)	-	6.56	0.037	KRAS, CDH1
Bladder cancer (hsa05219)	-	7.38	0.012	KRAS, CDH1
Endometrial cancer (hsa05213)	-	6.81	0.026	KRAS, CDH1
MicroRNAs in cancer (hsa05206)	NEW	5.38	0.029	KRAS, IL1B, CDH1
Thyroid cancer (hsa05216)	-	7.48	0.01	KRAS, CDH1
N-Glycan biosynthesis (hsa00510)	NEW	7.07	0.049	KRAS, CDH1
Chemokine signaling pathway (hsa04062)	NEW	5.19	0.045	KRAS, IL1B, CDH1
Hepatitis B (hsa05161)	NEW	5.52	0.016	KRAS, IL1B, CDH1

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Immune System	R-HSA-168256	2.37	4	KRAS, IL1RN, IL1B, CDH1
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	3	IL1RN, KRAS, IL1B
Signaling by Interleukins	R-HSA-449147	4.71	3	IL1RN, KRAS, IL1B
C-type lectin receptors (CLRs)	R-HSA-5621481	6.06	2	KRAS, IL1B
Innate Immune System	R-HSA-168249	3.17	2	KRAS, IL1B
Adaptive Immune System	R-HSA-1280218	3.19	2	KRAS, CDH1
Signal Transduction	R-HSA-162582	1.78	2	KRAS, CDH1
Interleukin-1 signaling	R-HSA-446652	7.52	2	IL1RN, IL1B

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Signaling by FGFR3 in disease (R-HSA-5655332)	NEW	8.52	0.009	KRAS, CDH1
Signaling by Interleukins (R-HSA-449147)	-	4.71	0.025	KRAS, IL1RN, IL1B, CDH1
SHC-mediated cascade:FGFR1 (R-HSA-5654688)	NEW	8.59	0.01	KRAS, CDH1
SHC-mediated cascade:FGFR2 (R-HSA-5654699)	NEW	8.28	0.016	KRAS, CDH1
SHC-mediated cascade:FGFR3 (R-HSA-5654704)	NEW	8.81	0.006	KRAS, CDH1
Transport to the Golgi and subsequent modification (R-HSA-948021)	NEW	7.81	0.046	KRAS, CDH1
Interleukin-1 signaling (R-HSA-446652)	-	7.52	0.02	IL1RN, IL1B
Signaling by FGFR2 in disease (R-HSA-5655253)	NEW	8.23	0.014	KRAS, CDH1
N-glycan antennae elongation in the medial/trans-Golgi (R-HSA-975576)	NEW	8.66	0.015	KRAS, CDH1

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	4	KRAS, IL1RN, IL1B, CDH1
protein binding (GO:0005515)	0.46	4	KRAS, IL1RN, IL1B, CDH1
cytokine receptor binding (GO:0005126)	4.14	2	IL1RN, IL1B
cation binding (GO:0043169)	1.4	2	KRAS, CDH1
cytokine activity (GO:0005125)	4.34	2	IL1RN, IL1B
interleukin-1 receptor binding (GO:0005149)	6.85	2	IL1RN, IL1B
growth factor receptor binding (GO:0070851)	4.87	2	IL1RN, IL1B
carbohydrate derivative binding (GO:0097367)	2.03	2	KRAS, CDH1
ion binding (GO:0043167)	1.36	2	KRAS, CDH1
protein domain specific binding (GO:0019904)	3.32	2	KRAS, IL1B
receptor binding (GO:0005102)	2.43	2	IL1RN, IL1B
metal ion binding (GO:0046872)	1.41	2	KRAS, CDH1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cytokine receptor binding (GO:0005126)	-	4.14	0.049	KRAS, IL1RN, IL1B, CDH1
interleukin-1 receptor binding (GO:0005149)	-	6.85	0.0	IL1RN, IL1B
sequence-specific DNA binding (GO:0043565)	NEW	2.79	0.036	KRAS, IL1RN, IL1B, CDH1
growth factor receptor binding (GO:0070851)	-	4.87	0.004	IL1RN, IL1B, CDH1
glycosaminoglycan binding (GO:0005539)	NEW	4.42	0.041	IL1RN, IL1B, CDH1
protein domain specific binding (GO:0019904)	-	3.32	0.007	KRAS, IL1B, CDH1
transferase activity, transferring glycosyl groups (GO:0016757)	NEW	4.08	0.025	KRAS, IL1B, CDH1
acetylglucosaminyltransferase activity (GO:0008375)	NEW	5.85	0.033	KRAS, CDH1
transferase activity, transferring hexosyl groups (GO:0016758)	NEW	4.43	0.007	KRAS, IL1B, CDH1
UDP-glycosyltransferase activity (GO:0008194)	NEW	4.81	0.002	KRAS, IL1B, CDH1
cytokine receptor activity (GO:0004896)	NEW	5.24	0.002	IL1RN, KRAS, IL1B

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
response to endogenous stimulus (GO:0009719)	2.79	4	KRAS, IL1RN, IL1B, CDH1
response to stimulus (GO:0050896)	1.22	4	KRAS, IL1RN, IL1B, CDH1
cellular process (GO:0009987)	0.26	4	KRAS, IL1RN, IL1B, CDH1
negative regulation of biological process (GO:0048519)	1.33	4	KRAS, IL1RN, IL1B, CDH1
regulation of cellular process (GO:0050794)	0.5	4	KRAS, IL1RN, IL1B, CDH1
negative regulation of cellular process (GO:0048523)	1.41	4	KRAS, IL1RN, IL1B, CDH1
response to organic cyclic compound (GO:0014070)	3.07	4	KRAS, IL1RN, IL1B, CDH1
single-organism cellular process (GO:0044763)	0.65	4	KRAS, IL1RN, IL1B, CDH1
single-organism process (GO:0044699)	0.48	4	KRAS, IL1RN, IL1B, CDH1
response to chemical (GO:0042221)	1.98	4	KRAS, IL1RN, IL1B, CDH1
biological regulation (GO:0065007)	0.39	4	KRAS, IL1RN, IL1B, CDH1
regulation of biological process (GO:0050789)	0.45	4	KRAS, IL1RN, IL1B, CDH1
response to organic substance (GO:0010033)	2.2	4	KRAS, IL1RN, IL1B, CDH1
response to glucocorticoid (GO:0051384)	4.63	3	IL1RN, KRAS, IL1B
positive regulation of metabolic process (GO:0009893)	1.74	3	KRAS, IL1B, CDH1
regulation of metabolic process (GO:0019222)	1.02	3	KRAS, IL1B, CDH1
regulation of cellular biosynthetic process (GO:0031326)	1.38	3	KRAS, IL1B, CDH1
regulation of cell adhesion (GO:0030155)	3.27	3	IL1RN, IL1B, CDH1
regulation of response to stimulus (GO:0048583)	1.54	3	IL1RN, KRAS, IL1B
regulation of cell-cell adhesion (GO:0022407)	3.79	3	IL1RN, IL1B, CDH1
positive regulation of gene expression (GO:0010628)	2.35	3	KRAS, IL1B, CDH1
regulation of signaling (GO:0023051)	1.72	3	IL1RN, KRAS, IL1B
regulation of cell communication (GO:0010646)	1.73	3	IL1RN, KRAS, IL1B
regulation of primary metabolic process (GO:0080090)	1.08	3	KRAS, IL1B, CDH1
single-organism metabolic process (GO:0044710)	1.63	3	IL1RN, KRAS, IL1B
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	3	KRAS, IL1B, CDH1
regulation of signal transduction (GO:0009966)	1.84	3	IL1RN, KRAS, IL1B
response to lipid (GO:0033993)	3.11	3	IL1RN, KRAS, IL1B
regulation of cellular metabolic process (GO:0031323)	1.07	3	KRAS, IL1B, CDH1
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	3	KRAS, IL1B, CDH1
organic substance metabolic process (GO:0071704)	0.63	3	IL1RN, KRAS, IL1B
positive regulation of biological process (GO:0048518)	1.2	3	KRAS, IL1B, CDH1
regulation of biological quality (GO:0065008)	1.68	3	IL1RN, KRAS, IL1B
positive regulation of cellular metabolic process (GO:0031325)	1.81	3	KRAS, IL1B, CDH1
developmental process (GO:0032502)	1.36	3	KRAS, IL1B, CDH1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	3	KRAS, IL1B, CDH1
response to corticosteroid (GO:0031960)	4.56	3	IL1RN, KRAS, IL1B
regulation of biosynthetic process (GO:0009889)	1.37	3	KRAS, IL1B, CDH1
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	3	KRAS, IL1B, CDH1
single-organism developmental process (GO:0044767)	1.49	3	KRAS, IL1B, CDH1
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	3	KRAS, IL1B, CDH1
metabolic process (GO:0008152)	0.58	3	IL1RN, KRAS, IL1B
regulation of RNA biosynthetic process (GO:2001141)	1.55	3	KRAS, IL1B, CDH1
localization (GO:0051179)	1.4	3	IL1RN, IL1B, CDH1
primary metabolic process (GO:0044238)	0.69	3	IL1RN, KRAS, IL1B
regulation of macromolecule metabolic process (GO:0060255)	1.08	3	KRAS, IL1B, CDH1
response to hormone (GO:0009725)	3.33	3	IL1RN, KRAS, IL1B
regulation of RNA metabolic process (GO:0051252)	1.52	3	KRAS, IL1B, CDH1
regulation of gene expression (GO:0010468)	1.37	3	KRAS, IL1B, CDH1
immune system process (GO:0002376)	2.29	3	IL1RN, KRAS, IL1B
regulation of transcription, DNA-templated (GO:0006355)	1.56	3	KRAS, IL1B, CDH1
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	3	KRAS, IL1B, CDH1
response to steroid hormone (GO:0048545)	4.24	3	IL1RN, KRAS, IL1B
positive regulation of cellular process (GO:0048522)	1.3	3	KRAS, IL1B, CDH1
regulation of intracellular protein transport (GO:0033157)	3.8	2	IL1B, CDH1
protein localization (GO:0008104)	2.36	2	IL1RN, CDH1
regulation of phosphate metabolic process (GO:0019220)	2.35	2	KRAS, IL1B
cytokine-mediated signaling pathway (GO:0019221)	3.6	2	KRAS, IL1B
regulation of transport (GO:0051049)	2.24	2	IL1B, CDH1
regulation of intracellular transport (GO:0032386)	3.58	2	IL1B, CDH1
positive regulation of response to stimulus (GO:0048584)	2.18	2	KRAS, IL1B
behavior (GO:0007610)	3.47	2	KRAS, IL1B
learning or memory (GO:0007611)	4.33	2	KRAS, IL1B
positive regulation of defense response (GO:0031349)	3.83	2	KRAS, IL1B
negative regulation of cell adhesion (GO:0007162)	4.33	2	IL1RN, CDH1
regulation of heterotypic cell-cell adhesion (GO:0034114)	6.84	2	IL1RN, IL1B
signal transduction (GO:0007165)	1.28	2	KRAS, IL1B
cell surface receptor signaling pathway (GO:0007166)	2.09	2	KRAS, IL1B
positive regulation of intracellular transport (GO:0032388)	4.08	2	IL1B, CDH1
regulation of defense response (GO:0031347)	3.11	2	KRAS, IL1B
cellular response to stimulus (GO:0051716)	1.97	2	IL1B, CDH1
negative regulation of signal transduction (GO:0009968)	2.75	2	IL1RN, IL1B
positive regulation of signal transduction (GO:0009967)	2.5	2	KRAS, IL1B
MAPK cascade (GO:0000165)	3.91	2	KRAS, IL1B
cellular response to organic substance (GO:0071310)	2.78	2	IL1B, CDH1
positive regulation of protein import (GO:1904591)	5.08	2	IL1B, CDH1
regulation of transcription factor import into nucleus (GO:0042990)	5.16	2	IL1B, CDH1
positive regulation of molecular function (GO:0044093)	2.23	2	KRAS, IL1B
phosphorylation (GO:0016310)	2.63	2	KRAS, IL1B
macromolecule localization (GO:0033036)	2.34	2	IL1RN, CDH1
negative regulation of response to stimulus (GO:0048585)	2.52	2	IL1RN, IL1B
regulation of cell proliferation (GO:0042127)	2.41	2	KRAS, IL1B
positive regulation of transport (GO:0051050)	2.9	2	IL1B, CDH1
social behavior (GO:0035176)	5.9	2	KRAS, IL1B
negative regulation of cell death (GO:0060548)	2.95	2	KRAS, IL1B
regulation of protein kinase activity (GO:0045859)	3.15	2	KRAS, IL1B
establishment of protein localization (GO:0045184)	2.53	2	IL1RN, CDH1
regulation of immune response (GO:0050776)	2.98	2	KRAS, IL1B
cell adhesion (GO:0007155)	2.82	2	IL1B, CDH1
intraspecies interaction between organisms (GO:0051703)	5.9	2	KRAS, IL1B
response to inorganic substance (GO:0010035)	3.56	2	IL1B, CDH1
response to abiotic stimulus (GO:0009628)	2.8	2	KRAS, IL1B
positive regulation of transcription factor import into nucleus (GO:0042993)	5.78	2	IL1B, CDH1
multi-organism behavior (GO:0051705)	5.6	2	KRAS, IL1B
multi-organism process (GO:0051704)	2.65	2	KRAS, IL1B
regulation of phosphorylation (GO:0042325)	2.5	2	KRAS, IL1B
single organism signaling (GO:0044700)	3.25	2	KRAS, IL1B
positive regulation of phosphorylation (GO:0042327)	2.9	2	KRAS, IL1B
cell migration (GO:0016477)	3.12	2	KRAS, IL1B
single-multicellular organism process (GO:0044707)	1.78	2	KRAS, IL1B
cell motility (GO:0048870)	3.02	2	KRAS, IL1B
protein metabolic process (GO:0019538)	1.45	2	KRAS, IL1B
single-organism behavior (GO:0044708)	3.79	2	KRAS, IL1B
response to organonitrogen compound (GO:0010243)	3.2	2	IL1B, CDH1
positive regulation of oxidoreductase activity (GO:0051353)	5.94	2	KRAS, IL1B
regulation of protein import (GO:1904589)	4.52	2	IL1B, CDH1
cellular response to chemical stimulus (GO:0070887)	2.57	2	IL1B, CDH1
positive regulation of biosynthetic process (GO:0009891)	2.29	2	IL1B, CDH1
movement of cell or subcellular component (GO:0006928)	2.61	2	KRAS, IL1B
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	2	KRAS, IL1B
positive regulation of protein transport (GO:0051222)	3.61	2	IL1B, CDH1
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	2	KRAS, IL1B
regulation of apoptotic process (GO:0042981)	2.5	2	KRAS, IL1B
cellular protein metabolic process (GO:0044267)	1.63	2	KRAS, IL1B
regulation of oxidoreductase activity (GO:0051341)	5.27	2	KRAS, IL1B
positive regulation of transferase activity (GO:0051347)	3.31	2	KRAS, IL1B
cellular macromolecule metabolic process (GO:0044260)	0.93	2	KRAS, IL1B
regulation of kinase activity (GO:0043549)	3.07	2	KRAS, IL1B
cellular component organization (GO:0016043)	1.24	2	KRAS, CDH1
cell-cell adhesion (GO:0098609)	3.34	2	IL1B, CDH1
positive regulation of immune system process (GO:0002684)	2.96	2	KRAS, IL1B
regulation of immune system process (GO:0002682)	2.5	2	KRAS, IL1B
cellular component organization or biogenesis (GO:0071840)	1.22	2	KRAS, CDH1
positive regulation of RNA metabolic process (GO:0051254)	2.51	2	IL1B, CDH1
regulation of molecular function (GO:0065009)	1.78	2	KRAS, IL1B
regulation of MAPK cascade (GO:0043408)	3.22	2	KRAS, IL1B
regulation of establishment of protein localization (GO:0070201)	3.02	2	IL1B, CDH1
single organism cell adhesion (GO:0098602)	3.63	2	IL1B, CDH1
lipid metabolic process (GO:0006629)	2.68	2	IL1RN, IL1B
regulation of developmental process (GO:0050793)	2.1	2	IL1RN, IL1B
regulation of monooxygenase activity (GO:0032768)	5.69	2	KRAS, IL1B
regulation of catalytic activity (GO:0050790)	1.97	2	KRAS, IL1B
positive regulation of MAPK cascade (GO:0043410)	3.57	2	KRAS, IL1B
acute-phase response (GO:0006953)	5.94	2	IL1RN, IL1B
macromolecule modification (GO:0043412)	1.73	2	KRAS, IL1B
protein modification process (GO:0036211)	1.79	2	KRAS, IL1B
regulation of multicellular organismal process (GO:0051239)	1.87	2	IL1RN, IL1B
immune response (GO:0006955)	2.86	2	IL1RN, IL1B
positive regulation of protein import into nucleus (GO:0042307)	5.11	2	IL1B, CDH1
acute inflammatory response (GO:0002526)	5.48	2	IL1RN, IL1B
positive regulation of intracellular signal transduction (GO:1902533)	2.95	2	KRAS, IL1B
establishment of localization (GO:0051234)	1.48	2	IL1RN, CDH1
defense response (GO:0006952)	2.78	2	IL1RN, IL1B
positive regulation of protein localization to nucleus (GO:1900182)	4.87	2	IL1B, CDH1
regulation of response to stress (GO:0080134)	2.53	2	KRAS, IL1B
positive regulation of protein modification process (GO:0031401)	2.7	2	KRAS, IL1B
cognition (GO:0050890)	4.2	2	KRAS, IL1B
response to stress (GO:0006950)	1.8	2	IL1RN, IL1B
regulation of transferase activity (GO:0051338)	2.88	2	KRAS, IL1B
positive regulation of nucleocytoplasmic transport (GO:0046824)	4.93	2	IL1B, CDH1
regulation of nucleocytoplasmic transport (GO:0046822)	4.33	2	IL1B, CDH1
cellular developmental process (GO:0048869)	1.82	2	KRAS, IL1B
positive regulation of kinase activity (GO:0033674)	3.54	2	KRAS, IL1B
positive regulation of monooxygenase activity (GO:0032770)	6.47	2	KRAS, IL1B
positive regulation of catalytic activity (GO:0043085)	2.4	2	KRAS, IL1B
inflammatory response (GO:0006954)	3.64	2	IL1RN, IL1B
response to radiation (GO:0009314)	3.69	2	KRAS, IL1B
regulation of cellular protein localization (GO:1903827)	3.43	2	IL1B, CDH1
positive regulation of MAP kinase activity (GO:0043406)	4.39	2	KRAS, IL1B
regulation of MAP kinase activity (GO:0043405)	3.95	2	KRAS, IL1B
signaling (GO:0023052)	3.25	2	KRAS, IL1B
negative regulation of cell communication (GO:0010648)	2.66	2	IL1RN, IL1B
regulation of protein targeting (GO:1903533)	4.0	2	IL1B, CDH1
regulation of protein import into nucleus (GO:0042306)	4.54	2	IL1B, CDH1
positive regulation of cell communication (GO:0010647)	2.41	2	KRAS, IL1B
positive regulation of establishment of protein localization (GO:1904951)	3.49	2	IL1B, CDH1
positive regulation of cellular protein localization (GO:1903829)	3.85	2	IL1B, CDH1
regulation of protein localization (GO:0032880)	2.88	2	IL1B, CDH1
regulation of intracellular signal transduction (GO:1902531)	2.31	2	KRAS, IL1B
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	KRAS, IL1B
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	IL1RN, IL1B
regulation of protein metabolic process (GO:0051246)	1.93	2	KRAS, IL1B
positive regulation of protein metabolic process (GO:0051247)	2.43	2	KRAS, IL1B
system process (GO:0003008)	2.3	2	KRAS, IL1B
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	KRAS, IL1B
regulation of protein modification process (GO:0031399)	2.32	2	KRAS, IL1B
signal transduction by protein phosphorylation (GO:0023014)	3.79	2	KRAS, IL1B
biological adhesion (GO:0022610)	2.81	2	IL1B, CDH1
positive regulation of cell proliferation (GO:0008284)	3.01	2	KRAS, IL1B
regulation of nitric-oxide synthase activity (GO:0050999)	5.9	2	KRAS, IL1B
multicellular organismal process (GO:0032501)	1.45	2	KRAS, IL1B
positive regulation of signaling (GO:0023056)	2.41	2	KRAS, IL1B
regulation of protein localization to nucleus (GO:1900180)	4.34	2	IL1B, CDH1
neurological system process (GO:0050877)	2.64	2	KRAS, IL1B
negative regulation of cell differentiation (GO:0045596)	3.33	2	KRAS, IL1B
regulation of cell differentiation (GO:0045595)	2.42	2	KRAS, IL1B
locomotion (GO:0040011)	2.91	2	KRAS, IL1B
regulation of localization (GO:0032879)	1.94	2	IL1B, CDH1
positive regulation of NF-kappaB transcription factor activity (GO:0051092)	4.85	2	KRAS, IL1B
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	2	KRAS, IL1B
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	2	KRAS, IL1B
regulation of cellular protein metabolic process (GO:0032268)	1.99	2	KRAS, IL1B
cellular response to organic cyclic compound (GO:0071407)	3.93	2	IL1B, CDH1
response to drug (GO:0042493)	3.71	2	IL1B, CDH1
positive regulation of immune response (GO:0050778)	3.4	2	KRAS, IL1B
macromolecule metabolic process (GO:0043170)	0.83	2	KRAS, IL1B
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	2	IL1B, CDH1
positive regulation of protein kinase activity (GO:0045860)	3.61	2	KRAS, IL1B
response to nitrogen compound (GO:1901698)	3.12	2	IL1B, CDH1
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	2	IL1B, CDH1
cellular response to nitrogen compound (GO:1901699)	3.79	2	IL1B, CDH1
single organismal cell-cell adhesion (GO:0016337)	3.69	2	IL1B, CDH1
regulation of cellular localization (GO:0060341)	3.03	2	IL1B, CDH1
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	2	IL1B, CDH1
homeostatic process (GO:0042592)	2.61	2	KRAS, IL1B
leukocyte migration (GO:0050900)	4.19	2	KRAS, IL1B
regulation of cell death (GO:0010941)	2.43	2	KRAS, IL1B
intracellular signal transduction (GO:0035556)	2.39	2	KRAS, IL1B
negative regulation of cell-cell adhesion (GO:0022408)	4.84	2	IL1RN, CDH1
regulation of protein transport (GO:0051223)	3.12	2	IL1B, CDH1
cellular response to organonitrogen compound (GO:0071417)	3.87	2	IL1B, CDH1
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	2	IL1B, CDH1
regulation of programmed cell death (GO:0043067)	2.49	2	KRAS, IL1B
negative regulation of apoptotic process (GO:0043066)	3.04	2	KRAS, IL1B
negative regulation of programmed cell death (GO:0043069)	3.02	2	KRAS, IL1B
protein phosphorylation (GO:0006468)	2.89	2	KRAS, IL1B
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	2	IL1B, CDH1
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	KRAS, IL1B
positive regulation of intracellular protein transport (GO:0090316)	4.19	2	IL1B, CDH1
cellular protein modification process (GO:0006464)	1.79	2	KRAS, IL1B
regulation of hormone levels (GO:0010817)	3.56	2	IL1RN, IL1B
regulation of phosphorus metabolic process (GO:0051174)	2.35	2	KRAS, IL1B
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	2	IL1B, CDH1
cell-cell signaling (GO:0007267)	3.35	2	KRAS, IL1B
cell communication (GO:0007154)	3.04	2	KRAS, IL1B
single-organism localization (GO:1902578)	2.09	2	IL1RN, CDH1
response to oxygen-containing compound (GO:1901700)	2.57	2	IL1B, CDH1
cellular response to oxygen-containing compound (GO:1901701)	3.22	2	IL1B, CDH1
response to alcohol (GO:0097305)	4.58	2	IL1B, CDH1
anatomical structure development (GO:0048856)	1.58	2	KRAS, CDH1
cellular metabolic process (GO:0044237)	0.69	2	KRAS, IL1B
cellular response to endogenous stimulus (GO:0071495)	3.33	2	IL1B, CDH1
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	KRAS, IL1B
regulation of multicellular organismal development (GO:2000026)	2.31	2	IL1RN, IL1B
phosphorus metabolic process (GO:0006793)	2.15	2	KRAS, IL1B
regulation of protein phosphorylation (GO:0001932)	2.57	2	KRAS, IL1B
negative regulation of signaling (GO:0023057)	2.65	2	IL1RN, IL1B
positive regulation of protein phosphorylation (GO:0001934)	2.95	2	KRAS, IL1B
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	2	IL1B, CDH1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
positive regulation of monooxygenase activity (GO:0032770)	-	6.47	0.005	KRAS, IL1B, CDH1
regulation of heterotypic cell-cell adhesion (GO:0034114)	-	6.84	0.038	IL1RN, IL1B
regulation of vitamin D biosynthetic process (GO:0060556)	NEW	7.53	0.011	IL1B, CDH1
cytokine-mediated signaling pathway (GO:0019221)	-	3.6	0.019	KRAS, IL1RN, IL1B, CDH1
regulation of peptidyl-serine phosphorylation (GO:0033135)	NEW	4.98	0.027	KRAS, IL1B, CDH1
regulation of cell adhesion (GO:0030155)	-	3.27	0.018	KRAS, IL1RN, IL1B, CDH1
tissue remodeling (GO:0048771)	NEW	5.54	0.014	KRAS, IL1B, CDH1
regulation of T cell activation (GO:0050863)	NEW	4.05	0.008	KRAS, IL1RN, IL1B, CDH1
chronic inflammatory response (GO:0002544)	NEW	7.16	0.036	IL1RN, IL1B
regulation of T cell differentiation (GO:0045580)	NEW	5.07	0.043	IL1RN, IL1B, CDH1
regulation of cell-cell adhesion (GO:0022407)	-	3.79	0.027	IL1RN, IL1B, CDH1
response to organic cyclic compound (GO:0014070)	-	3.07	0.002	KRAS, IL1RN, IL1B, CDH1
response to magnesium ion (GO:0032026)	NEW	6.55	0.036	KRAS, CDH1
regulation of response to cytokine stimulus (GO:0060759)	NEW	4.77	0.035	IL1RN, KRAS, IL1B
acute inflammatory response (GO:0002526)	-	5.48	0.049	IL1RN, IL1B
positive regulation of protein serine/threonine kinase activity (GO:0071902)	-	4.06	0.008	KRAS, IL1RN, IL1B, CDH1
response to lipopolysaccharide (GO:0032496)	NEW	4.03	0.004	KRAS, IL1RN, IL1B, CDH1
regulation of anion transport (GO:0044070)	NEW	5.25	0.016	IL1RN, IL1B, CDH1
regulation of apoptotic process (GO:0042981)	-	2.5	0.019	KRAS, IL1RN, IL1B, CDH1
fever generation (GO:0001660)	NEW	9.04	0.0	IL1RN, IL1B
peptide hormone secretion (GO:0030072)	NEW	5.69	0.006	IL1RN, KRAS, IL1B
response to endogenous stimulus (GO:0009719)	-	2.79	0.017	KRAS, IL1RN, IL1B, CDH1
regulation of oxidoreductase activity (GO:0051341)	-	5.27	0.018	KRAS, IL1B, CDH1
regulation of lymphocyte activation (GO:0051249)	NEW	3.73	0.03	KRAS, IL1RN, IL1B, CDH1
response to interleukin-1 (GO:0070555)	NEW	5.07	0.013	IL1RN, KRAS, IL1B
multicellular organismal homeostasis (GO:0048871)	NEW	5.07	0.027	IL1RN, IL1B
hormone secretion (GO:0046879)	NEW	5.48	0.014	IL1RN, KRAS, CDH1
epithelial tube branching involved in lung morphogenesis (GO:0060441)	NEW	6.9	0.04	KRAS, CDH1
regulation of programmed cell death (GO:0043067)	-	2.49	0.02	KRAS, IL1RN, IL1B, CDH1
positive regulation of leukocyte activation (GO:0002696)	NEW	4.0	0.01	KRAS, IL1RN, IL1B, CDH1
negative regulation of cell-cell adhesion (GO:0022408)	-	4.84	0.023	IL1RN, IL1B, CDH1
SMAD protein signal transduction (GO:0060395)	NEW	5.65	0.04	IL1B, CDH1
positive regulation of lymphocyte differentiation (GO:0045621)	NEW	5.35	0.016	IL1RN, IL1B, CDH1
positive regulation of cell activation (GO:0050867)	NEW	3.97	0.013	KRAS, IL1RN, IL1B, CDH1
cyclooxygenase pathway (GO:0019371)	NEW	7.33	0.022	KRAS, IL1B
negative regulation of cell migration (GO:0030336)	NEW	4.41	0.002	KRAS, IL1RN, IL1B, CDH1
negative regulation of transport (GO:0051051)	NEW	3.6	0.046	KRAS, IL1RN, IL1B, CDH1
T cell differentiation (GO:0030217)	NEW	5.11	0.049	KRAS, IL1B, CDH1
response to corticosteroid (GO:0031960)	-	4.56	0.001	KRAS, IL1RN, IL1B, CDH1
regulation of monooxygenase activity (GO:0032768)	-	5.69	0.032	KRAS, IL1B, CDH1
negative regulation of locomotion (GO:0040013)	NEW	4.22	0.005	KRAS, IL1RN, IL1B, CDH1
positive regulation of T cell activation (GO:0050870)	NEW	4.39	0.002	KRAS, IL1RN, IL1B, CDH1
positive regulation of T cell proliferation (GO:0042102)	NEW	5.16	0.022	KRAS, IL1B, CDH1
positive regulation of MAPK cascade (GO:0043410)	-	3.57	0.028	KRAS, IL1RN, IL1B, CDH1
negative regulation of ion transport (GO:0043271)	NEW	4.94	0.009	IL1RN, IL1B, CDH1
acute-phase response (GO:0006953)	-	5.94	0.021	IL1RN, IL1B
astrocyte cell migration (GO:0043615)	NEW	7.94	0.004	IL1B, CDH1
inflammatory response (GO:0006954)	-	3.64	0.042	KRAS, IL1RN, IL1B, CDH1
hormone transport (GO:0009914)	NEW	5.33	0.0	KRAS, IL1RN, IL1B, CDH1
regulation of organic acid transport (GO:0032890)	NEW	7.78	0.025	IL1RN, IL1B
temperature homeostasis (GO:0001659)	NEW	6.47	0.01	IL1RN, IL1B
response to drug (GO:0042493)	-	3.71	0.04	KRAS, IL1RN, IL1B, CDH1
regulation of hormone levels (GO:0010817)	-	3.56	0.007	KRAS, IL1RN, IL1B, CDH1
positive regulation of transcription factor import into nucleus (GO:0042993)	-	5.78	0.017	IL1B, CDH1
regulation of vitamin metabolic process (GO:0030656)	NEW	7.24	0.02	IL1B, CDH1
system process (GO:0003008)	-	2.3	0.011	KRAS, IL1RN, IL1B, CDH1
response to oxygen-containing compound (GO:1901700)	-	2.57	0.012	KRAS, IL1RN, IL1B, CDH1
positive regulation of NF-kappaB transcription factor activity (GO:0051092)	-	4.85	0.032	KRAS, IL1B, CDH1
negative regulation of cellular component movement (GO:0051271)	NEW	4.22	0.003	KRAS, IL1RN, IL1B, CDH1
heat generation (GO:0031649)	NEW	8.12	0.001	IL1RN, IL1B
regulation of cytokine-mediated signaling pathway (GO:0001959)	NEW	4.82	0.025	IL1RN, KRAS, IL1B
positive regulation of MAP kinase activity (GO:0043406)	-	4.39	0.004	KRAS, IL1RN, IL1B, CDH1
positive regulation of lymphocyte activation (GO:0051251)	NEW	4.07	0.008	KRAS, IL1RN, IL1B, CDH1
female pregnancy (GO:0007565)	NEW	5.08	0.025	IL1RN, IL1B, CDH1
response to organonitrogen compound (GO:0010243)	-	3.2	0.002	KRAS, IL1RN, IL1B, CDH1
regulation of cell death (GO:0010941)	-	2.43	0.023	KRAS, IL1RN, IL1B, CDH1
regulation of MAP kinase activity (GO:0043405)	-	3.95	0.01	KRAS, IL1RN, IL1B, CDH1
positive regulation of oxidoreductase activity (GO:0051353)	-	5.94	0.018	KRAS, IL1B, CDH1
peptide secretion (GO:0002790)	NEW	5.67	0.0	KRAS, IL1RN, IL1B, CDH1
amide transport (GO:0042886)	NEW	5.19	0.0	KRAS, IL1RN, IL1B, CDH1
positive regulation of myeloid cell differentiation (GO:0045639)	NEW	5.33	0.011	KRAS, IL1B, CDH1
response to molecule of bacterial origin (GO:0002237)	NEW	3.99	0.006	KRAS, IL1RN, IL1B, CDH1
negative regulation of cell motility (GO:2000146)	NEW	4.36	0.002	KRAS, IL1RN, IL1B, CDH1
peptide transport (GO:0015833)	NEW	5.44	0.0	KRAS, IL1RN, IL1B, CDH1
regulation of protein serine/threonine kinase activity (GO:0071900)	-	3.58	0.037	IL1RN, KRAS, IL1B
positive regulation of protein kinase activity (GO:0045860)	-	3.61	0.047	IL1RN, KRAS, IL1B
response to glucocorticoid (GO:0051384)	-	4.63	0.001	KRAS, IL1RN, IL1B, CDH1
response to nitrogen compound (GO:1901698)	-	3.12	0.002	KRAS, IL1RN, IL1B, CDH1
response to steroid hormone (GO:0048545)	-	4.24	0.047	KRAS, IL1RN, IL1B, CDH1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cytoplasm (GO:0005737)	1.01	4	KRAS, IL1RN, IL1B, CDH1
cell part (GO:0044464)	0.11	4	KRAS, IL1RN, IL1B, CDH1
intracellular part (GO:0044424)	0.28	4	KRAS, IL1RN, IL1B, CDH1
membrane-bounded organelle (GO:0043227)	0.47	4	KRAS, IL1RN, IL1B, CDH1
organelle (GO:0043226)	0.4	4	KRAS, IL1RN, IL1B, CDH1
extracellular organelle (GO:0043230)	1.89	3	IL1RN, IL1B, CDH1
vesicle (GO:0031982)	1.64	3	IL1RN, IL1B, CDH1
extracellular exosome (GO:0070062)	1.89	3	IL1RN, IL1B, CDH1
membrane (GO:0016020)	0.68	3	IL1RN, KRAS, CDH1
cytoplasmic part (GO:0044444)	0.82	3	KRAS, IL1B, CDH1
membrane-bounded vesicle (GO:0031988)	1.71	3	IL1RN, IL1B, CDH1
intracellular organelle (GO:0043229)	0.51	3	KRAS, IL1B, CDH1
extracellular region (GO:0005576)	2.18	3	IL1RN, IL1B, CDH1
plasma membrane (GO:0005886)	1.39	3	IL1RN, KRAS, CDH1
extracellular vesicle (GO:1903561)	1.89	3	IL1RN, IL1B, CDH1
extracellular region part (GO:0044421)	1.57	3	IL1RN, IL1B, CDH1
intracellular membrane-bounded organelle (GO:0043231)	0.6	3	KRAS, IL1B, CDH1
extracellular space (GO:0005615)	2.63	2	IL1RN, IL1B
vacuole (GO:0005773)	2.92	2	IL1B, CDH1
cytosol (GO:0005829)	1.68	2	KRAS, IL1B
anchoring junction (GO:0070161)	3.61	2	KRAS, CDH1
intracellular (GO:0005622)	2.37	2	IL1RN, KRAS
adherens junction (GO:0005912)	3.66	2	KRAS, CDH1
membrane part (GO:0044425)	0.95	2	KRAS, CDH1
cell-substrate adherens junction (GO:0005924)	3.83	2	KRAS, CDH1
focal adhesion (GO:0005925)	3.83	2	KRAS, CDH1
plasma membrane part (GO:0044459)	1.95	2	KRAS, CDH1
cell junction (GO:0030054)	2.75	2	KRAS, CDH1
cell-substrate junction (GO:0030055)	3.82	2	KRAS, CDH1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
T-tubule (GO:0030315)	NEW	6.09	0.031	IL1B, CDH1
external side of plasma membrane (GO:0009897)	NEW	4.46	0.033	KRAS, IL1B, CDH1
early endosome (GO:0005769)	NEW	4.34	0.013	KRAS, IL1B, CDH1
vacuolar membrane (GO:0005774)	NEW	3.45	0.041	KRAS, IL1B, CDH1