Disease table of DIABETES MELLITUS, INSULIN-DEPENDENT OMIM ID: 222100

Gene-disease associations table

GeneAssociated with DIABETES MELLITUS, INSULIN-DEPENDENT inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
OAS1OMIMHGNC link12q24.131222100
FOXP3OMIMHGNC linkXp11.232304790, 222100
HNF1AClinVar, OMIMHGNC link12q24.316125853, 222100, 144700, 142330, 612520, 600496
PTPN22OMIM, HUMSAVARHGNC link1p13.23180300, 152700, 222100
ITPR3OMIMHGNC link6p21.311222100

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
12q242OAS1, HNF1A
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
12q22OAS1, HNF1A
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
12q2OAS1, HNF1A
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
122OAS1, HNF1A
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
FOXP3YES10CDKN1A, IL2RA, TLR10, IL2, CCR4, ERBB2, SATB1, CTLA4, BRCA1, ZNF2050
HNF1AYES26GPR39, FABP1, CYP1A2, NT5E, SLC22A9, ALB, SLCO1B3, UGT2B7, UGT2B17, SLC22A10, APOM, CDH17, IGFBP1, TM4SF1, CRP, UGT1A1, UGT1A8, LCT, UGT1A7, AKR1C4, UGT1A10, ACAT2, UGT1A9, AFP, CSRP1, MTTP0
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
OAS1YES1STAT30
FOXP3YES9RELA, VDR, IRF1, MSC, NFATC2, PGR, SP3, NFKB1, STAT10
HNF1AYES2RXRA, HNF4A0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
FOXP3HNF1ANo2EP300, SIRT1
HNF1APTPN22No1VCP

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
HNF1AITPR3No-1SRC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.372ITPR3, OAS1
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185FOXP3, ITPR3, PTPN22, HNF1A, OAS1
protein binding (GO:0005515) 0.465FOXP3, ITPR3, PTPN22, HNF1A, OAS1
cation binding (GO:0043169) 1.43FOXP3, ITPR3, OAS1
organic cyclic compound binding (GO:0097159) 1.053FOXP3, HNF1A, OAS1
ion binding (GO:0043167) 1.363FOXP3, ITPR3, OAS1
nucleic acid binding (GO:0003676) 1.443FOXP3, HNF1A, OAS1
metal ion binding (GO:0046872) 1.413FOXP3, ITPR3, OAS1
heterocyclic compound binding (GO:1901363) 1.063FOXP3, HNF1A, OAS1
transcription regulatory region DNA binding (GO:0044212) 3.032FOXP3, HNF1A
sequence-specific DNA binding (GO:0043565) 2.792FOXP3, HNF1A
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652FOXP3, HNF1A
transcription factor binding (GO:0008134) 3.462FOXP3, HNF1A
regulatory region DNA binding (GO:0000975) 3.032FOXP3, HNF1A
regulatory region nucleic acid binding (GO:0001067) 3.032FOXP3, HNF1A
enzyme binding (GO:0019899) 2.272FOXP3, PTPN22
small molecule binding (GO:0036094) 1.892ITPR3, OAS1
catalytic activity (GO:0003824) 1.052PTPN22, OAS1
identical protein binding (GO:0042802) 2.632FOXP3, HNF1A
nucleic acid binding transcription factor activity (GO:0001071) 2.652FOXP3, HNF1A
core promoter binding (GO:0001047) 4.712FOXP3, HNF1A
DNA binding (GO:0003677) 1.922FOXP3, HNF1A
protein dimerization activity (GO:0046983) 2.722FOXP3, HNF1A
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292FOXP3, HNF1A
protein homodimerization activity (GO:0042803) 3.162FOXP3, HNF1A
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism process (GO:0044699) 0.485FOXP3, HNF1A, PTPN22, ITPR3, OAS1
response to stimulus (GO:0050896) 1.225FOXP3, ITPR3, PTPN22, HNF1A, OAS1
cellular process (GO:0009987) 0.265FOXP3, HNF1A, PTPN22, ITPR3, OAS1
regulation of cellular process (GO:0050794) 0.55FOXP3, HNF1A, PTPN22, ITPR3, OAS1
biological regulation (GO:0065007) 0.395FOXP3, HNF1A, PTPN22, ITPR3, OAS1
single-organism cellular process (GO:0044763) 0.655FOXP3, HNF1A, PTPN22, ITPR3, OAS1
signal transduction (GO:0007165) 1.285FOXP3, HNF1A, PTPN22, ITPR3, OAS1
negative regulation of biological process (GO:0048519) 1.335FOXP3, ITPR3, PTPN22, HNF1A, OAS1
regulation of biological process (GO:0050789) 0.455FOXP3, HNF1A, PTPN22, ITPR3, OAS1
negative regulation of cellular process (GO:0048523) 1.415FOXP3, HNF1A, PTPN22, ITPR3, OAS1
regulation of primary metabolic process (GO:0080090) 1.084FOXP3, PTPN22, HNF1A, OAS1
regulation of metabolic process (GO:0019222) 1.024FOXP3, PTPN22, HNF1A, OAS1
macromolecular complex subunit organization (GO:0043933) 2.144FOXP3, HNF1A, ITPR3, OAS1
regulation of transport (GO:0051049) 2.244FOXP3, HNF1A, PTPN22, ITPR3
regulation of cellular metabolic process (GO:0031323) 1.074FOXP3, PTPN22, HNF1A, OAS1
homeostatic process (GO:0042592) 2.614FOXP3, ITPR3, HNF1A, OAS1
regulation of secretion by cell (GO:1903530) 3.284FOXP3, ITPR3, PTPN22, HNF1A
regulation of protein transport (GO:0051223) 3.124FOXP3, ITPR3, PTPN22, HNF1A
cellular component organization or biogenesis (GO:0071840) 1.224FOXP3, HNF1A, ITPR3, OAS1
regulation of protein localization (GO:0032880) 2.884FOXP3, HNF1A, PTPN22, ITPR3
regulation of protein secretion (GO:0050708) 3.774FOXP3, ITPR3, PTPN22, HNF1A
regulation of secretion (GO:0051046) 3.24FOXP3, ITPR3, PTPN22, HNF1A
cellular component organization (GO:0016043) 1.244FOXP3, ITPR3, HNF1A, OAS1
organic substance metabolic process (GO:0071704) 0.634FOXP3, PTPN22, HNF1A, OAS1
positive regulation of biological process (GO:0048518) 1.24FOXP3, HNF1A, PTPN22, ITPR3
regulation of biological quality (GO:0065008) 1.684FOXP3, HNF1A, ITPR3, OAS1
regulation of establishment of protein localization (GO:0070201) 3.024FOXP3, ITPR3, PTPN22, HNF1A
regulation of macromolecule metabolic process (GO:0060255) 1.084FOXP3, PTPN22, HNF1A, OAS1
metabolic process (GO:0008152) 0.584FOXP3, PTPN22, HNF1A, OAS1
response to chemical (GO:0042221) 1.984HNF1A, PTPN22, ITPR3, OAS1
regulation of localization (GO:0032879) 1.944FOXP3, HNF1A, PTPN22, ITPR3
response to organic substance (GO:0010033) 2.24HNF1A, PTPN22, ITPR3, OAS1
primary metabolic process (GO:0044238) 0.694FOXP3, PTPN22, HNF1A, OAS1
cellular metabolic process (GO:0044237) 0.694FOXP3, PTPN22, HNF1A, OAS1
positive regulation of cellular process (GO:0048522) 1.34FOXP3, ITPR3, PTPN22, HNF1A
negative regulation of metabolic process (GO:0009892) 1.933FOXP3, PTPN22, HNF1A
positive regulation of metabolic process (GO:0009893) 1.743FOXP3, PTPN22, HNF1A
positive regulation of cellular metabolic process (GO:0031325) 1.813FOXP3, PTPN22, HNF1A
negative regulation of cellular metabolic process (GO:0031324) 2.013FOXP3, PTPN22, HNF1A
regulation of response to stimulus (GO:0048583) 1.543FOXP3, PTPN22, HNF1A
cellular biosynthetic process (GO:0044249) 1.373FOXP3, HNF1A, OAS1
negative regulation of gene expression (GO:0010629) 2.483FOXP3, PTPN22, HNF1A
positive regulation of gene expression (GO:0010628) 2.353FOXP3, PTPN22, HNF1A
cellular response to chemical stimulus (GO:0070887) 2.573PTPN22, ITPR3, OAS1
regulation of signaling (GO:0023051) 1.723HNF1A, PTPN22, ITPR3
regulation of cell communication (GO:0010646) 1.733HNF1A, PTPN22, ITPR3
organic cyclic compound biosynthetic process (GO:1901362) 1.663FOXP3, HNF1A, OAS1
single-multicellular organism process (GO:0044707) 1.783FOXP3, ITPR3, HNF1A
organic cyclic compound metabolic process (GO:1901360) 1.263FOXP3, HNF1A, OAS1
nucleobase-containing compound metabolic process (GO:0006139) 1.353FOXP3, HNF1A, OAS1
cellular response to stimulus (GO:0051716) 1.973PTPN22, ITPR3, OAS1
negative regulation of macromolecule metabolic process (GO:0010605) 2.013FOXP3, PTPN22, HNF1A
positive regulation of macromolecule metabolic process (GO:0010604) 1.813FOXP3, PTPN22, HNF1A
response to external biotic stimulus (GO:0043207) 3.133FOXP3, PTPN22, OAS1
cell surface receptor signaling pathway (GO:0007166) 2.093FOXP3, PTPN22, OAS1
cellular response to organic substance (GO:0071310) 2.783PTPN22, ITPR3, OAS1
regulation of molecular function (GO:0065009) 1.783FOXP3, PTPN22, OAS1
regulation of gene expression (GO:0010468) 1.373FOXP3, PTPN22, HNF1A
heterocycle biosynthetic process (GO:0018130) 1.73FOXP3, HNF1A, OAS1
multicellular organismal process (GO:0032501) 1.453FOXP3, ITPR3, HNF1A
organic substance biosynthetic process (GO:1901576) 1.343FOXP3, HNF1A, OAS1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433FOXP3, HNF1A, OAS1
cellular aromatic compound metabolic process (GO:0006725) 1.33FOXP3, HNF1A, OAS1
cell activation (GO:0001775) 3.473FOXP3, PTPN22, ITPR3
regulation of nitrogen compound metabolic process (GO:0051171) 1.363FOXP3, HNF1A, OAS1
regulation of multicellular organismal process (GO:0051239) 1.873FOXP3, PTPN22, ITPR3
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723FOXP3, HNF1A, OAS1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593FOXP3, HNF1A, OAS1
cellular nitrogen compound metabolic process (GO:0034641) 1.223FOXP3, HNF1A, OAS1
heterocycle metabolic process (GO:0046483) 1.313FOXP3, HNF1A, OAS1
response to oxygen-containing compound (GO:1901700) 2.573HNF1A, PTPN22, ITPR3
macromolecule metabolic process (GO:0043170) 0.833FOXP3, PTPN22, HNF1A
response to biotic stimulus (GO:0009607) 3.093FOXP3, PTPN22, OAS1
cellular macromolecule metabolic process (GO:0044260) 0.933FOXP3, PTPN22, HNF1A
response to external stimulus (GO:0009605) 2.553FOXP3, PTPN22, OAS1
regulation of RNA metabolic process (GO:0051252) 1.523FOXP3, HNF1A, OAS1
biosynthetic process (GO:0009058) 1.323FOXP3, HNF1A, OAS1
chemical homeostasis (GO:0048878) 2.973HNF1A, ITPR3, OAS1
immune system process (GO:0002376) 2.293FOXP3, PTPN22, OAS1
nitrogen compound metabolic process (GO:0006807) 1.133FOXP3, HNF1A, OAS1
aromatic compound biosynthetic process (GO:0019438) 1.73FOXP3, HNF1A, OAS1
regulation of peptide transport (GO:0090087) 4.372HNF1A, ITPR3
regulation of tumor necrosis factor production (GO:0032680) 5.132FOXP3, PTPN22
regulation of mononuclear cell proliferation (GO:0032944) 4.452FOXP3, PTPN22
negative regulation of secretion (GO:0051048) 4.442FOXP3, PTPN22
negative regulation of response to stimulus (GO:0048585) 2.522FOXP3, PTPN22
positive regulation of response to stimulus (GO:0048584) 2.182FOXP3, PTPN22
carbohydrate homeostasis (GO:0033500) 4.62HNF1A, OAS1
negative regulation of cell adhesion (GO:0007162) 4.332FOXP3, PTPN22
small molecule metabolic process (GO:0044281) 2.382HNF1A, OAS1
regulation of production of molecular mediator of immune response (GO:0002700) 5.12FOXP3, PTPN22
regulation of defense response (GO:0031347) 3.112FOXP3, PTPN22
single-organism metabolic process (GO:0044710) 1.632HNF1A, OAS1
single-organism biosynthetic process (GO:0044711) 2.82HNF1A, OAS1
positive regulation of cell adhesion (GO:0045785) 3.792FOXP3, PTPN22
regulation of signal transduction (GO:0009966) 1.842PTPN22, HNF1A
cellular developmental process (GO:0048869) 1.822FOXP3, PTPN22
interspecies interaction between organisms (GO:0044419) 3.082FOXP3, OAS1
immune effector process (GO:0002252) 3.582FOXP3, OAS1
negative regulation of molecular function (GO:0044092) 2.742FOXP3, PTPN22
system process (GO:0003008) 2.32HNF1A, ITPR3
positive regulation of alpha-beta T cell activation (GO:0046635) 5.762FOXP3, PTPN22
negative regulation of tumor necrosis factor production (GO:0032720) 5.992FOXP3, PTPN22
regulation of cell proliferation (GO:0042127) 2.412FOXP3, PTPN22
regulation of alpha-beta T cell activation (GO:0046634) 5.482FOXP3, PTPN22
negative regulation of transport (GO:0051051) 3.62FOXP3, PTPN22
T cell differentiation (GO:0030217) 5.112FOXP3, PTPN22
regulation of T cell proliferation (GO:0042129) 4.742FOXP3, PTPN22
regulation of peptide hormone secretion (GO:0090276) 4.412HNF1A, ITPR3
lymphocyte activation (GO:0046649) 3.962FOXP3, PTPN22
regulation of RNA biosynthetic process (GO:2001141) 1.552FOXP3, HNF1A
response to other organism (GO:0051707) 3.482FOXP3, OAS1
multi-organism process (GO:0051704) 2.652FOXP3, OAS1
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062FOXP3, PTPN22
organonitrogen compound metabolic process (GO:1901564) 2.322HNF1A, OAS1
organonitrogen compound biosynthetic process (GO:1901566) 2.852HNF1A, OAS1
protein metabolic process (GO:0019538) 1.452PTPN22, HNF1A
response to organonitrogen compound (GO:0010243) 3.22PTPN22, ITPR3
negative regulation of cellular biosynthetic process (GO:0031327) 2.492FOXP3, HNF1A
response to nitrogen compound (GO:1901698) 3.122PTPN22, ITPR3
cellular component assembly (GO:0022607) 2.142ITPR3, OAS1
negative regulation of biosynthetic process (GO:0009890) 2.472FOXP3, HNF1A
positive regulation of biosynthetic process (GO:0009891) 2.292FOXP3, HNF1A
response to stress (GO:0006950) 1.82HNF1A, OAS1
regulation of interferon-gamma production (GO:0032649) 5.212FOXP3, PTPN22
positive regulation of lymphocyte proliferation (GO:0050671) 4.852FOXP3, PTPN22
leukocyte activation (GO:0045321) 3.762FOXP3, PTPN22
positive regulation of mononuclear cell proliferation (GO:0032946) 4.842FOXP3, PTPN22
negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556) 5.942FOXP3, PTPN22
regulation of tumor necrosis factor superfamily cytokine production (GO:1903555) 5.12FOXP3, PTPN22
activation of immune response (GO:0002253) 3.672FOXP3, PTPN22
negative regulation of protein transport (GO:0051224) 4.442FOXP3, PTPN22
positive regulation of cell communication (GO:0010647) 2.412PTPN22, ITPR3
nucleic acid-templated transcription (GO:0097659) 1.912FOXP3, HNF1A
cellular protein metabolic process (GO:0044267) 1.632PTPN22, HNF1A
immune response-regulating signaling pathway (GO:0002764) 3.722FOXP3, PTPN22
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242FOXP3, HNF1A
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962FOXP3, PTPN22
regulation of cytokine secretion (GO:0050707) 4.742FOXP3, PTPN22
macromolecular complex assembly (GO:0065003) 2.552ITPR3, OAS1
positive regulation of immune system process (GO:0002684) 2.962FOXP3, PTPN22
regulation of immune system process (GO:0002682) 2.52FOXP3, PTPN22
negative regulation of immune system process (GO:0002683) 3.852FOXP3, PTPN22
positive regulation of RNA metabolic process (GO:0051254) 2.512FOXP3, HNF1A
lymphocyte aggregation (GO:0071593) 4.442FOXP3, PTPN22
positive regulation of cellular component organization (GO:0051130) 2.682FOXP3, HNF1A
single organism cell adhesion (GO:0098602) 3.632FOXP3, PTPN22
cell-cell adhesion (GO:0098609) 3.342FOXP3, PTPN22
regulation of viral process (GO:0050792) 3.892PTPN22, OAS1
ion transport (GO:0006811) 2.662HNF1A, ITPR3
regulation of catalytic activity (GO:0050790) 1.972PTPN22, OAS1
regulation of biosynthetic process (GO:0009889) 1.372FOXP3, HNF1A
regulation of insulin secretion (GO:0050796) 4.572HNF1A, ITPR3
regulation of symbiosis, encompassing mutualism through parasitism (GO:0043903) 3.822PTPN22, OAS1
macromolecule modification (GO:0043412) 1.732PTPN22, HNF1A
protein modification process (GO:0036211) 1.792PTPN22, HNF1A
immune response (GO:0006955) 2.862FOXP3, OAS1
establishment of localization (GO:0051234) 1.482HNF1A, ITPR3
leukocyte differentiation (GO:0002521) 4.132FOXP3, PTPN22
RNA metabolic process (GO:0016070) 1.592FOXP3, HNF1A
negative regulation of cytokine secretion (GO:0050710) 5.922FOXP3, PTPN22
regulation of response to stress (GO:0080134) 2.532FOXP3, PTPN22
positive regulation of protein modification process (GO:0031401) 2.72FOXP3, PTPN22
regulation of multi-organism process (GO:0043900) 3.62PTPN22, OAS1
negative regulation of leukocyte activation (GO:0002695) 4.792FOXP3, PTPN22
regulation of leukocyte activation (GO:0002694) 3.62FOXP3, PTPN22
negative regulation of interleukin-6 production (GO:0032715) 6.172FOXP3, PTPN22
positive regulation of leukocyte activation (GO:0002696) 4.02FOXP3, PTPN22
transcription, DNA-templated (GO:0006351) 1.912FOXP3, HNF1A
response to virus (GO:0009615) 4.212FOXP3, OAS1
regulation of immune effector process (GO:0002697) 3.712FOXP3, PTPN22
positive regulation of immune effector process (GO:0002699) 4.692FOXP3, PTPN22
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532FOXP3, HNF1A
RNA biosynthetic process (GO:0032774) 1.842FOXP3, HNF1A
regulation of response to external stimulus (GO:0032101) 3.062FOXP3, PTPN22
regulation of cell adhesion (GO:0030155) 3.272FOXP3, PTPN22
cell differentiation (GO:0030154) 2.142FOXP3, PTPN22
regulation of cellular component organization (GO:0051128) 2.012FOXP3, HNF1A
positive regulation of signaling (GO:0023056) 2.412PTPN22, ITPR3
negative regulation of secretion by cell (GO:1903531) 4.552FOXP3, PTPN22
cellular macromolecule biosynthetic process (GO:0034645) 1.662FOXP3, HNF1A
negative regulation of establishment of protein localization (GO:1904950) 4.392FOXP3, PTPN22
regulation of cellular protein metabolic process (GO:0032268) 1.992FOXP3, PTPN22
response to endogenous stimulus (GO:0009719) 2.792PTPN22, ITPR3
negative regulation of protein metabolic process (GO:0051248) 2.822FOXP3, PTPN22
regulation of lymphocyte activation (GO:0051249) 3.732FOXP3, PTPN22
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122FOXP3, HNF1A
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392FOXP3, HNF1A
positive regulation of multicellular organismal process (GO:0051240) 2.492FOXP3, PTPN22
negative regulation of multicellular organismal process (GO:0051241) 2.842FOXP3, PTPN22
regulation of protein metabolic process (GO:0051246) 1.932FOXP3, PTPN22
positive regulation of protein metabolic process (GO:0051247) 2.432FOXP3, PTPN22
negative regulation of leukocyte cell-cell adhesion (GO:1903038) 5.192FOXP3, PTPN22
positive regulation of leukocyte cell-cell adhesion (GO:1903039) 4.352FOXP3, PTPN22
positive regulation of cellular protein metabolic process (GO:0032270) 2.492FOXP3, PTPN22
transport (GO:0006810) 1.512HNF1A, ITPR3
regulation of protein modification process (GO:0031399) 2.322FOXP3, PTPN22
biological adhesion (GO:0022610) 2.812FOXP3, PTPN22
regulation of interleukin-6 production (GO:0032675) 5.082FOXP3, PTPN22
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.012FOXP3, PTPN22
positive regulation of cell proliferation (GO:0008284) 3.012FOXP3, PTPN22
regulation of nucleic acid-templated transcription (GO:1903506) 1.552FOXP3, HNF1A
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712FOXP3, HNF1A
regulation of hormone secretion (GO:0046883) 4.182HNF1A, ITPR3
negative regulation of transcription, DNA-templated (GO:0045892) 2.752FOXP3, HNF1A
T cell activation (GO:0042110) 4.452FOXP3, PTPN22
protein oligomerization (GO:0051259) 3.712ITPR3, OAS1
negative regulation of cellular protein metabolic process (GO:0032269) 2.882FOXP3, PTPN22
regulation of immune response (GO:0050776) 2.982FOXP3, PTPN22
chromatin remodeling (GO:0006338) 4.782FOXP3, HNF1A
glucose homeostasis (GO:0042593) 4.62HNF1A, OAS1
positive regulation of lymphocyte activation (GO:0051251) 4.072FOXP3, PTPN22
negative regulation of lymphocyte activation (GO:0051250) 4.952FOXP3, PTPN22
negative regulation of RNA metabolic process (GO:0051253) 2.662FOXP3, HNF1A
regulation of lymphocyte proliferation (GO:0050670) 4.462FOXP3, PTPN22
positive regulation of immune response (GO:0050778) 3.42FOXP3, PTPN22
macromolecule biosynthetic process (GO:0009059) 1.612FOXP3, HNF1A
positive regulation of RNA biosynthetic process (GO:1902680) 2.542FOXP3, HNF1A
regulation of cytokine production (GO:0001817) 3.42FOXP3, PTPN22
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812FOXP3, HNF1A
lymphocyte differentiation (GO:0030098) 4.492FOXP3, PTPN22
negative regulation of protein modification process (GO:0031400) 3.42FOXP3, PTPN22
negative regulation of cytokine production (GO:0001818) 4.42FOXP3, PTPN22
positive regulation of cytokine production (GO:0001819) 3.822FOXP3, PTPN22
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562FOXP3, HNF1A
cellular response to nitrogen compound (GO:1901699) 3.792PTPN22, ITPR3
single organismal cell-cell adhesion (GO:0016337) 3.692FOXP3, PTPN22
negative regulation of T cell activation (GO:0050868) 5.262FOXP3, PTPN22
positive regulation of cellular biosynthetic process (GO:0031328) 2.32FOXP3, HNF1A
regulation of cell activation (GO:0050865) 3.532FOXP3, PTPN22
regulation of cellular biosynthetic process (GO:0031326) 1.382FOXP3, HNF1A
positive regulation of cell activation (GO:0050867) 3.972FOXP3, PTPN22
negative regulation of cell activation (GO:0050866) 4.672FOXP3, PTPN22
regulation of T cell activation (GO:0050863) 4.052FOXP3, PTPN22
nucleic acid metabolic process (GO:0090304) 1.462FOXP3, HNF1A
regulation of cell-cell adhesion (GO:0022407) 3.792FOXP3, PTPN22
negative regulation of cell-cell adhesion (GO:0022408) 4.842FOXP3, PTPN22
positive regulation of cell-cell adhesion (GO:0022409) 4.232FOXP3, PTPN22
protein complex subunit organization (GO:0071822) 2.62ITPR3, OAS1
regulation of transcription, DNA-templated (GO:0006355) 1.562FOXP3, HNF1A
chromatin organization (GO:0006325) 3.282FOXP3, HNF1A
cellular response to organonitrogen compound (GO:0071417) 3.872PTPN22, ITPR3
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462FOXP3, HNF1A
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62FOXP3, HNF1A
regulation of leukocyte proliferation (GO:0070663) 4.42FOXP3, PTPN22
regulation of macromolecule biosynthetic process (GO:0010556) 1.432FOXP3, HNF1A
positive regulation of leukocyte proliferation (GO:0070665) 4.792FOXP3, PTPN22
antigen receptor-mediated signaling pathway (GO:0050851) 4.432FOXP3, PTPN22
T cell receptor signaling pathway (GO:0050852) 4.712FOXP3, PTPN22
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352FOXP3, HNF1A
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552FOXP3, HNF1A
positive regulation of T cell proliferation (GO:0042102) 5.162FOXP3, PTPN22
protein complex assembly (GO:0006461) 2.782ITPR3, OAS1
cellular protein modification process (GO:0006464) 1.792PTPN22, HNF1A
regulation of hormone levels (GO:0010817) 3.562HNF1A, ITPR3
negative regulation of RNA biosynthetic process (GO:1902679) 2.72FOXP3, HNF1A
single-organism transport (GO:0044765) 2.182HNF1A, ITPR3
multi-organism cellular process (GO:0044764) 3.142FOXP3, OAS1
T cell aggregation (GO:0070489) 4.452FOXP3, PTPN22
positive regulation of T cell activation (GO:0050870) 4.392FOXP3, PTPN22
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472FOXP3, HNF1A
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292FOXP3, HNF1A
cell adhesion (GO:0007155) 2.822FOXP3, PTPN22
leukocyte aggregation (GO:0070486) 4.412FOXP3, PTPN22
leukocyte cell-cell adhesion (GO:0007159) 4.262FOXP3, PTPN22
localization (GO:0051179) 1.42HNF1A, ITPR3
single-organism localization (GO:1902578) 2.092HNF1A, ITPR3
immune response-activating signal transduction (GO:0002757) 3.82FOXP3, PTPN22
cellular response to oxygen-containing compound (GO:1901701) 3.222PTPN22, ITPR3
regulation of peptide secretion (GO:0002791) 4.382HNF1A, ITPR3
cellular response to endogenous stimulus (GO:0071495) 3.332PTPN22, ITPR3
negative regulation of protein secretion (GO:0050709) 5.062FOXP3, PTPN22
phosphate-containing compound metabolic process (GO:0006796) 2.162PTPN22, OAS1
viral process (GO:0016032) 3.152FOXP3, OAS1
phosphorus metabolic process (GO:0006793) 2.152PTPN22, OAS1
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152FOXP3, OAS1
positive regulation of transcription, DNA-templated (GO:0045893) 2.562FOXP3, HNF1A

NET-GE enrichment

Term New enriched termICP valueGenes
homeostatic process (GO:0042592) -2.610.033FOXP3, ITPR3, HNF1A, OAS1
immune response-activating cell surface receptor signaling pathway (GO:0002429) -4.060.033FOXP3, PTPN22, ITPR3
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.015FOXP3, ITPR3, PTPN22, HNF1A, OAS1
intracellular membrane-bounded organelle (GO:0043231) 0.65FOXP3, HNF1A, PTPN22, ITPR3, OAS1
nucleus (GO:0005634) 1.075FOXP3, HNF1A, PTPN22, ITPR3, OAS1
cell part (GO:0044464) 0.115FOXP3, HNF1A, PTPN22, ITPR3, OAS1
intracellular organelle (GO:0043229) 0.515FOXP3, ITPR3, PTPN22, HNF1A, OAS1
intracellular part (GO:0044424) 0.285FOXP3, HNF1A, PTPN22, ITPR3, OAS1
membrane-bounded organelle (GO:0043227) 0.475FOXP3, HNF1A, PTPN22, ITPR3, OAS1
organelle (GO:0043226) 0.45FOXP3, HNF1A, PTPN22, ITPR3, OAS1
protein complex (GO:0043234) 1.513FOXP3, HNF1A, ITPR3
cytoplasmic part (GO:0044444) 0.823PTPN22, ITPR3, OAS1
macromolecular complex (GO:0032991) 1.353FOXP3, HNF1A, ITPR3
intracellular organelle part (GO:0044446) 0.812HNF1A, ITPR3
endoplasmic reticulum (GO:0005783) 2.562ITPR3, OAS1
cytosol (GO:0005829) 1.682ITPR3, OAS1
nucleoplasm (GO:0005654) 1.892HNF1A, ITPR3
neuron part (GO:0097458) 2.642HNF1A, ITPR3
nuclear part (GO:0044428) 1.552HNF1A, ITPR3
membrane part (GO:0044425) 0.952PTPN22, ITPR3
perinuclear region of cytoplasm (GO:0048471) 3.352PTPN22, ITPR3
cell projection (GO:0042995) 2.472HNF1A, ITPR3
plasma membrane part (GO:0044459) 1.952PTPN22, ITPR3
organelle part (GO:0044422) 0.792HNF1A, ITPR3

NET-GE enrichment

Term New enriched termICP valueGenes
cytoplasm (GO:0005737) -1.010.043FOXP3, HNF1A, PTPN22, ITPR3, OAS1