Disease table of RENAL CELL CARCINOMA, NONPAPILLARY OMIM ID: 144700

Gene-disease associations table

GeneAssociated with RENAL CELL CARCINOMA, NONPAPILLARY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
FLCNOMIM, HUMSAVARHGNC link17p11.24135150, 144700, 173600, 114500
DIRC2OMIMHGNC link3q21.11144700
HNF1BOMIMHGNC link17q123125853, 137920, 144700
VHLOMIM, HUMSAVARHGNC link3p25.34193300, 144700, PS133100, 171300
HNF1AOMIMHGNC link12q24.316125853, 222100, 144700, 142330, 612520, 600496
RNF139OMIMHGNC link8q24.131144700
OGG1OMIMHGNC link3p25.31144700

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
3p25.32OGG1, VHL
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
3p252OGG1, VHL
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
3p22OGG1, VHL
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
3p2OGG1, VHL
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
33OGG1, DIRC2, VHL
172FLCN, HNF1B
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
VHLYES18CA9, STRA13, TCF4, TFRC, ANGPT2, CXCR4, CCND1, DAB2, KLF10, CDKN1C, CA12, TP53, NMU, HIF1A, SPARC, VEGFA, IGF1R, CDKN1B0
HNF1AYES26GPR39, FABP1, CYP1A2, NT5E, SLC22A9, ALB, SLCO1B3, UGT2B7, UGT2B17, SLC22A10, APOM, CDH17, IGFBP1, TM4SF1, CRP, UGT1A1, UGT1A8, LCT, UGT1A7, AKR1C4, UGT1A10, ACAT2, UGT1A9, AFP, CSRP1, MTTP0
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
VHLYES1HIF1A0
HNF1AYES2RXRA, HNF4A0
OGG1YES2NFYA, TP530
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
FLCNVHLNo2GAG-POL, APP
HNF1BHNF1AYes2HNF1A, PCBD1
VHLHNF1ANo5KAT2B, ACTB, EP300, CBX3, SIRT1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
FLCNVHLNo-1CCND1
FLCNHNF1ANo-1CCND1
HNF1BHNF1ANo-4ONECUT1, PCBD1, CREBBP, DPP4
VHLHNF1ANo-4MYC, HDAC1, EP300, CCND1
VHLRNF139No-2UBC, COPS5
VHLOGG1No-1TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Renal cell carcinomahsa052116.62VHL, FLCN
Maturity onset diabetes of the younghsa049508.072HNF1B, HNF1A

NET-GE enrichment

Term New enriched termICP valueGenes
Renal cell carcinoma (hsa05211) -6.60.02VHL, FLCN
Maturity onset diabetes of the young (hsa04950) -8.070.003HNF1B, HNF1A
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Regulation of beta-cell developmentR-HSA-1867127.982HNF1B, HNF1A
Developmental BiologyR-HSA-12667383.482HNF1B, HNF1A

NET-GE enrichment

Term New enriched termICP valueGenes
Regulation of beta-cell development (R-HSA-186712) -7.980.002HNF1B, HNF1A
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.186VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
protein binding (GO:0005515) 0.466VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
catalytic activity (GO:0003824) 1.053VHL, RNF139, OGG1
organic cyclic compound binding (GO:0097159) 1.053HNF1B, HNF1A, OGG1
heterocyclic compound binding (GO:1901363) 1.063HNF1B, HNF1A, OGG1
nucleic acid binding (GO:0003676) 1.443HNF1B, HNF1A, OGG1
DNA binding (GO:0003677) 1.923HNF1B, HNF1A, OGG1
ubiquitin-like protein transferase activity (GO:0019787) 3.692VHL, RNF139
sequence-specific DNA binding (GO:0043565) 2.792HNF1B, HNF1A
protein heterodimerization activity (GO:0046982) 3.642HNF1B, HNF1A
nucleic acid binding transcription factor activity (GO:0001071) 2.652HNF1B, HNF1A
transcription regulatory region DNA binding (GO:0044212) 3.032HNF1B, HNF1A
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652HNF1B, HNF1A
ubiquitin protein ligase activity (GO:0061630) 4.472VHL, RNF139
transcription factor binding (GO:0008134) 3.462VHL, HNF1A
regulatory region nucleic acid binding (GO:0001067) 3.032HNF1B, HNF1A
enzyme binding (GO:0019899) 2.272VHL, RNF139
transferase activity (GO:0016740) 1.952VHL, RNF139
macromolecular complex binding (GO:0044877) 2.612HNF1B, FLCN
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292HNF1B, HNF1A
regulatory region DNA binding (GO:0000975) 3.032HNF1B, HNF1A
protein complex binding (GO:0032403) 3.092HNF1B, FLCN
protein dimerization activity (GO:0046983) 2.722HNF1B, HNF1A
ubiquitin-like protein ligase activity (GO:0061659) 4.442VHL, RNF139
ubiquitin-protein transferase activity (GO:0004842) 3.732VHL, RNF139
identical protein binding (GO:0042802) 2.632HNF1B, HNF1A
protein homodimerization activity (GO:0042803) 3.162HNF1B, HNF1A

NET-GE enrichment

Term New enriched termICP valueGenes
protein complex binding (GO:0032403) -3.090.001VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
negative regulation of metabolic process (GO:0009892) 1.936VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of primary metabolic process (GO:0080090) 1.086VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of metabolic process (GO:0019222) 1.026VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of cellular biosynthetic process (GO:0031326) 1.386VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
negative regulation of cellular metabolic process (GO:0031324) 2.016VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of cellular metabolic process (GO:0031323) 1.076VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of biological process (GO:0050789) 0.456VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
single-organism process (GO:0044699) 0.486VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
negative regulation of macromolecule metabolic process (GO:0010605) 2.016VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.466VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
biological regulation (GO:0065007) 0.396VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
negative regulation of biological process (GO:0048519) 1.336VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of gene expression (GO:0010468) 1.376VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of macromolecule metabolic process (GO:0060255) 1.086VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
cellular process (GO:0009987) 0.266VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of biosynthetic process (GO:0009889) 1.376VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of cellular process (GO:0050794) 0.56VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
single-organism cellular process (GO:0044763) 0.656VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of nitrogen compound metabolic process (GO:0051171) 1.366VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.476VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
regulation of macromolecule biosynthetic process (GO:0010556) 1.436VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
negative regulation of cellular process (GO:0048523) 1.416VHL, HNF1A, OGG1, HNF1B, RNF139, FLCN
positive regulation of metabolic process (GO:0009893) 1.745VHL, HNF1B, HNF1A, RNF139, FLCN
negative regulation of biosynthetic process (GO:0009890) 2.475VHL, HNF1B, HNF1A, RNF139, FLCN
negative regulation of cellular biosynthetic process (GO:0031327) 2.495VHL, RNF139, HNF1A, HNF1B, FLCN
positive regulation of cellular metabolic process (GO:0031325) 1.815VHL, HNF1B, HNF1A, RNF139, FLCN
negative regulation of gene expression (GO:0010629) 2.485VHL, HNF1B, HNF1A, RNF139, FLCN
positive regulation of macromolecule metabolic process (GO:0010604) 1.815VHL, HNF1B, HNF1A, RNF139, FLCN
cellular macromolecule metabolic process (GO:0044260) 0.935VHL, HNF1B, HNF1A, RNF139, OGG1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.65VHL, HNF1B, HNF1A, RNF139, FLCN
organic substance metabolic process (GO:0071704) 0.635VHL, HNF1B, HNF1A, RNF139, OGG1
positive regulation of biological process (GO:0048518) 1.25VHL, HNF1B, HNF1A, RNF139, FLCN
regulation of biological quality (GO:0065008) 1.685VHL, HNF1B, HNF1A, RNF139, FLCN
developmental process (GO:0032502) 1.365VHL, HNF1B, HNF1A, FLCN, OGG1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.555VHL, HNF1B, HNF1A, OGG1, FLCN
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.435VHL, HNF1B, HNF1A, OGG1, FLCN
regulation of nucleic acid-templated transcription (GO:1903506) 1.555VHL, HNF1B, HNF1A, OGG1, FLCN
single-organism developmental process (GO:0044767) 1.495VHL, HNF1B, HNF1A, FLCN, OGG1
metabolic process (GO:0008152) 0.585VHL, HNF1B, HNF1A, RNF139, OGG1
regulation of RNA biosynthetic process (GO:2001141) 1.555VHL, HNF1B, HNF1A, FLCN, OGG1
primary metabolic process (GO:0044238) 0.695VHL, HNF1B, HNF1A, RNF139, OGG1
response to stimulus (GO:0050896) 1.225VHL, HNF1B, HNF1A, RNF139, OGG1
regulation of RNA metabolic process (GO:0051252) 1.525VHL, HNF1B, HNF1A, FLCN, OGG1
cellular metabolic process (GO:0044237) 0.695VHL, HNF1B, HNF1A, RNF139, OGG1
macromolecule metabolic process (GO:0043170) 0.835VHL, HNF1B, HNF1A, RNF139, OGG1
regulation of transcription, DNA-templated (GO:0006355) 1.565VHL, HNF1B, HNF1A, FLCN, OGG1
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.535VHL, HNF1B, HNF1A, RNF139, FLCN
positive regulation of cellular process (GO:0048522) 1.35VHL, HNF1B, HNF1A, RNF139, FLCN
positive regulation of biosynthetic process (GO:0009891) 2.294VHL, HNF1B, HNF1A, FLCN
response to stress (GO:0006950) 1.84VHL, RNF139, HNF1A, OGG1
regulation of response to stimulus (GO:0048583) 1.544HNF1B, HNF1A, OGG1, FLCN
positive regulation of gene expression (GO:0010628) 2.354VHL, HNF1B, HNF1A, FLCN
regulation of cell death (GO:0010941) 2.434VHL, HNF1B, FLCN, OGG1
regulation of apoptotic process (GO:0042981) 2.54VHL, HNF1B, FLCN, OGG1
cellular component organization or biogenesis (GO:0071840) 1.224VHL, HNF1B, HNF1A, FLCN
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.124VHL, HNF1B, HNF1A, FLCN
positive regulation of cellular biosynthetic process (GO:0031328) 2.34VHL, HNF1B, HNF1A, FLCN
cellular component organization (GO:0016043) 1.244VHL, HNF1B, HNF1A, FLCN
regulation of programmed cell death (GO:0043067) 2.494VHL, HNF1B, OGG1, FLCN
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.564VHL, HNF1B, HNF1A, FLCN
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354VHL, HNF1B, HNF1A, FLCN
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.714VHL, HNF1B, HNF1A, FLCN
negative regulation of RNA biosynthetic process (GO:1902679) 2.74VHL, HNF1B, HNF1A, FLCN
macromolecule modification (GO:0043412) 1.734VHL, RNF139, HNF1A, OGG1
negative regulation of transcription, DNA-templated (GO:0045892) 2.754VHL, HNF1B, HNF1A, FLCN
positive regulation of transcription, DNA-templated (GO:0045893) 2.564VHL, HNF1B, HNF1A, FLCN
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.294VHL, HNF1B, HNF1A, FLCN
response to chemical (GO:0042221) 1.984HNF1B, HNF1A, RNF139, OGG1
regulation of localization (GO:0032879) 1.944RNF139, HNF1A, FLCN, OGG1
response to organic substance (GO:0010033) 2.24HNF1B, HNF1A, RNF139, OGG1
negative regulation of RNA metabolic process (GO:0051253) 2.664VHL, HNF1B, HNF1A, FLCN
positive regulation of RNA metabolic process (GO:0051254) 2.514VHL, HNF1B, HNF1A, FLCN
positive regulation of RNA biosynthetic process (GO:1902680) 2.544VHL, HNF1B, HNF1A, FLCN
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.394VHL, HNF1B, HNF1A, FLCN
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.244VHL, HNF1B, HNF1A, FLCN
regulation of cellular localization (GO:0060341) 3.033RNF139, OGG1, FLCN
regulation of transport (GO:0051049) 2.243RNF139, HNF1A, OGG1
regulation of cellular component organization (GO:0051128) 2.013HNF1B, HNF1A, FLCN
nucleic acid metabolic process (GO:0090304) 1.463HNF1B, HNF1A, OGG1
cellular nitrogen compound metabolic process (GO:0034641) 1.223HNF1B, HNF1A, OGG1
nitrogen compound metabolic process (GO:0006807) 1.133HNF1B, HNF1A, OGG1
signal transduction (GO:0007165) 1.283HNF1B, HNF1A, FLCN
regulation of signaling (GO:0023051) 1.723HNF1B, HNF1A, FLCN
anatomical structure morphogenesis (GO:0009653) 2.533VHL, HNF1B, HNF1A
organic cyclic compound metabolic process (GO:1901360) 1.263HNF1B, HNF1A, OGG1
regulation of protein localization (GO:0032880) 2.883HNF1A, OGG1, FLCN
cellular protein metabolic process (GO:0044267) 1.633VHL, RNF139, HNF1A
cellular response to stimulus (GO:0051716) 1.973VHL, RNF139, OGG1
regulation of cell communication (GO:0010646) 1.733HNF1B, HNF1A, FLCN
regulation of signal transduction (GO:0009966) 1.843HNF1B, HNF1A, FLCN
animal organ development (GO:0048513) 2.533HNF1B, HNF1A, FLCN
negative regulation of programmed cell death (GO:0043069) 3.023VHL, HNF1B, OGG1
regulation of cell proliferation (GO:0042127) 2.413VHL, RNF139, FLCN
negative regulation of cell proliferation (GO:0008285) 3.263VHL, RNF139, FLCN
multicellular organismal process (GO:0032501) 1.453HNF1B, HNF1A, FLCN
nucleobase-containing compound metabolic process (GO:0006139) 1.353HNF1B, HNF1A, OGG1
negative regulation of cell death (GO:0060548) 2.953VHL, HNF1B, OGG1
transport (GO:0006810) 1.513HNF1A, HNF1B, DIRC2
cellular aromatic compound metabolic process (GO:0006725) 1.33HNF1B, HNF1A, OGG1
single-organism metabolic process (GO:0044710) 1.633RNF139, HNF1A, OGG1
cellular protein modification process (GO:0006464) 1.793VHL, RNF139, HNF1A
regulation of cell differentiation (GO:0045595) 2.423VHL, HNF1B, FLCN
protein modification process (GO:0036211) 1.793VHL, RNF139, HNF1A
negative regulation of apoptotic process (GO:0043066) 3.043VHL, HNF1B, OGG1
establishment of localization (GO:0051234) 1.483HNF1A, HNF1B, DIRC2
localization (GO:0051179) 1.43HNF1A, HNF1B, DIRC2
heterocycle metabolic process (GO:0046483) 1.313HNF1B, HNF1A, OGG1
response to oxygen-containing compound (GO:1901700) 2.573HNF1B, HNF1A, OGG1
single-multicellular organism process (GO:0044707) 1.783HNF1B, HNF1A, FLCN
protein metabolic process (GO:0019538) 1.453VHL, RNF139, HNF1A
anatomical structure development (GO:0048856) 1.583HNF1B, HNF1A, FLCN
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813HNF1B, HNF1A, FLCN
cellular response to stress (GO:0033554) 2.513VHL, RNF139, OGG1
protein localization (GO:0008104) 2.362HNF1B, HNF1A
negative regulation of response to stimulus (GO:0048585) 2.522OGG1, FLCN
regulation of Wnt signaling pathway (GO:0030111) 3.982HNF1B, HNF1A
small molecule metabolic process (GO:0044281) 2.382HNF1A, OGG1
organic cyclic compound biosynthetic process (GO:1901362) 1.662HNF1B, HNF1A
endocrine pancreas development (GO:0031018) 6.362HNF1B, HNF1A
single-organism catabolic process (GO:0044712) 3.212RNF139, OGG1
cellular developmental process (GO:0048869) 1.822VHL, HNF1B
protein modification by small protein conjugation or removal (GO:0070647) 2.952VHL, RNF139
hormone secretion (GO:0046879) 5.482HNF1B, HNF1A
protein modification by small protein conjugation (GO:0032446) 3.12VHL, RNF139
macromolecule localization (GO:0033036) 2.342HNF1B, HNF1A
regulation of intracellular transport (GO:0032386) 3.582RNF139, OGG1
establishment of protein localization (GO:0045184) 2.532HNF1B, HNF1A
developmental process involved in reproduction (GO:0003006) 3.362HNF1B, HNF1A
regulation of pronephros size (GO:0035565) 9.042HNF1B, HNF1A
regulation of kidney size (GO:0035564) 8.122HNF1B, HNF1A
cellular catabolic process (GO:0044248) 2.622RNF139, OGG1
single organism reproductive process (GO:0044702) 2.732HNF1B, HNF1A
organonitrogen compound metabolic process (GO:1901564) 2.322HNF1A, OGG1
response to monosaccharide (GO:0034284) 4.772HNF1B, HNF1A
protein ubiquitination (GO:0016567) 3.282VHL, RNF139
aromatic compound biosynthetic process (GO:0019438) 1.72HNF1B, HNF1A
regulation of transcription initiation from RNA polymerase II promoter (GO:0060260) 6.592HNF1B, HNF1A
positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261) 6.92HNF1B, HNF1A
cellular component assembly (GO:0022607) 2.142HNF1B, FLCN
negative regulation of kidney development (GO:0090185) 6.92HNF1B, FLCN
regulation of kidney development (GO:0090183) 5.722HNF1B, FLCN
secretion by cell (GO:0032940) 3.592HNF1B, HNF1A
regulation of protein transport (GO:0051223) 3.122HNF1A, OGG1
nucleic acid-templated transcription (GO:0097659) 1.912HNF1B, HNF1A
insulin secretion (GO:0030073) 6.092HNF1B, HNF1A
organic substance biosynthetic process (GO:1901576) 1.342HNF1B, HNF1A
organic substance catabolic process (GO:1901575) 2.452RNF139, OGG1
regulation of anatomical structure size (GO:0090066) 3.782HNF1B, HNF1A
protein secretion (GO:0009306) 4.972HNF1B, HNF1A
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012HNF1B, HNF1A
heterocycle biosynthetic process (GO:0018130) 1.72HNF1B, HNF1A
positive regulation of cellular component organization (GO:0051130) 2.682HNF1B, HNF1A
regulation of establishment of protein localization (GO:0070201) 3.022HNF1A, OGG1
regulation of developmental process (GO:0050793) 2.12HNF1B, FLCN
amide transport (GO:0042886) 5.192HNF1B, HNF1A
regulation of multicellular organismal process (GO:0051239) 1.872HNF1B, FLCN
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722HNF1B, HNF1A
regulation of protein complex assembly (GO:0043254) 3.832HNF1B, HNF1A
RNA metabolic process (GO:0016070) 1.592HNF1B, HNF1A
regulation of protein localization to nucleus (GO:1900180) 4.342OGG1, FLCN
secretion (GO:0046903) 3.382HNF1B, HNF1A
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592HNF1B, HNF1A
regulation of protein stability (GO:0031647) 4.332VHL, RNF139
single-organism transport (GO:0044765) 2.182HNF1B, HNF1A
regulation of DNA-templated transcription, initiation (GO:2000142) 6.292HNF1B, HNF1A
transcription, DNA-templated (GO:0006351) 1.912HNF1B, HNF1A
RNA biosynthetic process (GO:0032774) 1.842HNF1B, HNF1A
regulation of cellular protein localization (GO:1903827) 3.432OGG1, FLCN
cellular biosynthetic process (GO:0044249) 1.372HNF1B, HNF1A
peptide transport (GO:0015833) 5.442HNF1B, HNF1A
cellular macromolecule biosynthetic process (GO:0034645) 1.662HNF1B, HNF1A
response to organic cyclic compound (GO:0014070) 3.072HNF1B, OGG1
negative regulation of protein metabolic process (GO:0051248) 2.822RNF139, FLCN
negative regulation of multicellular organismal process (GO:0051241) 2.842HNF1B, FLCN
regulation of protein metabolic process (GO:0051246) 1.932RNF139, FLCN
positive regulation of protein metabolic process (GO:0051247) 2.432RNF139, FLCN
positive regulation of cellular protein metabolic process (GO:0032270) 2.492RNF139, FLCN
regulation of protein modification process (GO:0031399) 2.322RNF139, FLCN
proteolysis (GO:0006508) 2.732VHL, RNF139
reproductive structure development (GO:0048608) 4.082HNF1B, HNF1A
positive regulation of protein complex assembly (GO:0031334) 4.442HNF1B, HNF1A
response to oxidative stress (GO:0006979) 3.92HNF1A, OGG1
negative regulation of developmental process (GO:0051093) 3.172HNF1B, FLCN
negative regulation of cellular protein metabolic process (GO:0032269) 2.882RNF139, FLCN
regulation of cellular protein metabolic process (GO:0032268) 1.992RNF139, FLCN
response to drug (GO:0042493) 3.712HNF1B, OGG1
gland development (GO:0048732) 4.152HNF1B, HNF1A
positive regulation of protein modification process (GO:0031401) 2.72RNF139, FLCN
macromolecular complex subunit organization (GO:0043933) 2.142HNF1B, HNF1A
liver development (GO:0001889) 4.982HNF1B, HNF1A
hormone transport (GO:0009914) 5.332HNF1B, HNF1A
regulation of growth (GO:0040008) 3.262HNF1B, FLCN
nitrogen compound transport (GO:0071705) 3.542HNF1B, HNF1A
peptide hormone secretion (GO:0030072) 5.692HNF1B, HNF1A
organic substance transport (GO:0071702) 2.152HNF1B, HNF1A
positive regulation of DNA-templated transcription, initiation (GO:2000144) 6.552HNF1B, HNF1A
embryonic morphogenesis (GO:0048598) 3.722HNF1B, HNF1A
signal release (GO:0023061) 4.652HNF1B, HNF1A
regulation of hormone levels (GO:0010817) 3.562HNF1B, HNF1A
reproductive process (GO:0022414) 2.552HNF1B, HNF1A
biosynthetic process (GO:0009058) 1.322HNF1B, HNF1A
macromolecule biosynthetic process (GO:0009059) 1.612HNF1B, HNF1A
catabolic process (GO:0009056) 2.382RNF139, OGG1
single-organism localization (GO:1902578) 2.092HNF1B, HNF1A
response to hexose (GO:0009746) 4.822HNF1B, HNF1A
response to carbohydrate (GO:0009743) 4.622HNF1B, HNF1A
peptide secretion (GO:0002790) 5.672HNF1B, HNF1A
response to glucose (GO:0009749) 4.862HNF1B, HNF1A
regulation of cellular component biogenesis (GO:0044087) 3.082HNF1B, HNF1A
regulation of multicellular organismal development (GO:2000026) 2.312HNF1B, FLCN
protein transport (GO:0015031) 2.622HNF1B, HNF1A
positive regulation of cellular component biogenesis (GO:0044089) 3.712HNF1B, HNF1A

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of transcription initiation from RNA polymerase II promoter (GO:0060260) -6.590.045HNF1B, HNF1A
positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261) -6.90.008HNF1B, HNF1A
regulation of kidney development (GO:0090183) -5.720.01VHL, HNF1B, FLCN
regulation of DNA-templated transcription, initiation (GO:2000142) -6.290.008HNF1B, HNF1A
positive regulation of DNA-templated transcription, initiation (GO:2000144) -6.550.002HNF1B, HNF1A
insulin secretion (GO:0030073) -6.090.036HNF1B, HNF1A
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.67VHL, HNF1A, DIRC2, OGG1, HNF1B, RNF139, FLCN
cell part (GO:0044464) 0.117VHL, HNF1A, DIRC2, OGG1, HNF1B, RNF139, FLCN
intracellular organelle (GO:0043229) 0.517VHL, HNF1A, DIRC2, OGG1, HNF1B, RNF139, FLCN
intracellular part (GO:0044424) 0.287VHL, HNF1A, DIRC2, OGG1, HNF1B, RNF139, FLCN
membrane-bounded organelle (GO:0043227) 0.477VHL, HNF1A, DIRC2, OGG1, HNF1B, RNF139, FLCN
organelle (GO:0043226) 0.47VHL, HNF1A, DIRC2, OGG1, HNF1B, RNF139, FLCN
intracellular organelle part (GO:0044446) 0.816VHL, HNF1A, DIRC2, OGG1, HNF1B, RNF139
organelle part (GO:0044422) 0.796VHL, HNF1A, DIRC2, OGG1, HNF1B, RNF139
protein complex (GO:0043234) 1.515VHL, HNF1B, HNF1A, RNF139, OGG1
nucleus (GO:0005634) 1.075VHL, HNF1B, HNF1A, OGG1, FLCN
macromolecular complex (GO:0032991) 1.355VHL, HNF1B, HNF1A, RNF139, OGG1
cytoplasmic part (GO:0044444) 0.825VHL, RNF139, DIRC2, FLCN, OGG1
nucleoplasm (GO:0005654) 1.894VHL, HNF1B, HNF1A, OGG1
membrane (GO:0016020) 0.684VHL, RNF139, DIRC2, FLCN
nuclear part (GO:0044428) 1.554VHL, HNF1B, HNF1A, OGG1
cytoplasm (GO:0005737) 1.013VHL, HNF1A, FLCN
primary cilium (GO:0072372) 4.642HNF1A, FLCN
lytic vacuole (GO:0000323) 3.892DIRC2, FLCN
endoplasmic reticulum (GO:0005783) 2.562VHL, RNF139
vacuole (GO:0005773) 2.922DIRC2, FLCN
integral component of membrane (GO:0016021) 1.142RNF139, DIRC2
mitochondrion (GO:0005739) 2.422VHL, OGG1
lysosome (GO:0005764) 3.892DIRC2, FLCN
transcription factor complex (GO:0005667) 4.12HNF1B, HNF1A
cilium (GO:0005929) 3.892HNF1A, FLCN
membrane part (GO:0044425) 0.952RNF139, DIRC2
cell projection (GO:0042995) 2.472HNF1A, FLCN
intrinsic component of membrane (GO:0031224) 1.132RNF139, DIRC2