Disease table of DIABETES MELLITUS, NONINSULIN-DEPENDENT OMIM ID: 125853

Gene-disease associations table

Gene	Associated with DIABETES MELLITUS, NONINSULIN-DEPENDENT in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
HMGA1	OMIM	HGNC link	6p21.31	1	125853
LIPC	ClinVar, OMIM	HGNC link	15q21.3	3	614025, 612797, 125853
SLC2A2	ClinVar, OMIM	HGNC link	3q26.2	2	227810, 125853
INSR	ClinVar, HUMSAVAR	HGNC link	19p13.2	5	610549, 125853, PS256450, 246200, 262190
SLC30A8	ClinVar, OMIM	HGNC link	8q24.11	1	125853
GPD2	ClinVar, OMIM	HGNC link	2q24.1	1	125853
PPP1R3A	HUMSAVAR	HGNC link	7q31.1	2	PS151660, 125853
RETN	ClinVar, OMIM	HGNC link	19p13.2	1	125853
HNF1B	ClinVar, OMIM, HUMSAVAR	HGNC link	17q12	3	125853, 137920, 144700
HNF1A	ClinVar, OMIM	HGNC link	12q24.31	6	125853, 222100, 144700, 142330, 612520, 600496
KCNJ11	ClinVar, OMIM	HGNC link	11p15.1	5	610582, 606176, 616329, PS256450, 125853
IRS2	OMIM	HGNC link	13q34	1	125853
GCK	OMIM	HGNC link	7p13	4	125851, PS256450, 606176, 125853
ENPP1	ClinVar, OMIM	HGNC link	6q23.2	5	615522, PS193100, 125853, 601665, PS208000
PAX4	ClinVar, OMIM, HUMSAVAR	HGNC link	7q32.1	3	612225, 612227, 125853
AKT2	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.2	2	240900, 125853
MTNR1B	OMIM	HGNC link	11q14.3	1	125853
GCGR	ClinVar, OMIM	HGNC link	17q25.3	1	125853
PTPN1	OMIM	HGNC link	20q13.13	1	125853
IGF2BP2	ClinVar, OMIM	HGNC link	3q27.2	1	125853
MAPK8IP1	ClinVar, OMIM, HUMSAVAR	HGNC link	11p11.2	1	125853
NEUROD1	ClinVar, OMIM	HGNC link	2q31.3	2	606394, 125853
PPARG	OMIM	HGNC link	3p25.2	5	601665, PS137800, 125853, 609338, PS151660
SLC2A4	ClinVar, HUMSAVAR	HGNC link	17p13.1	1	125853
HNF4A	ClinVar, OMIM, HUMSAVAR	HGNC link	20q13.12	3	125850, PS134600, 125853
IRS1	ClinVar, OMIM, HUMSAVAR	HGNC link	2q36.3	1	125853
TCF7L2	ClinVar, OMIM	HGNC link	10q25.2	1	125853
CAPN10	ClinVar	HGNC link	2q37.3	2	601283, 125853
IL6	ClinVar, OMIM	HGNC link	7p15.3	5	108010, 148000, 604302, 125853, PS266600
ABCC8	ClinVar, OMIM	HGNC link	11p15.1	5	240800, 610374, 606176, PS256450, 125853
PDX1	OMIM	HGNC link	13q12.2	3	606392, PS260370, 125853
WFS1	OMIM	HGNC link	4p16.1	5	PS124900, 222300, PS116200, 614296, 125853
CDKAL1	ClinVar, OMIM	HGNC link	6p22.3	1	125853

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
11p15.1	2	ABCC8, KCNJ11
19p13.2	2	INSR, RETN

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
20q13	2	PTPN1, HNF4A
19p13	2	INSR, RETN
11p15	2	ABCC8, KCNJ11

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
7q3	2	PPP1R3A, PAX4
11p1	3	MAPK8IP1, ABCC8, KCNJ11
2q3	3	IRS1, NEUROD1, CAPN10
6p2	2	HMGA1, CDKAL1
3q2	2	SLC2A2, IGF2BP2
7p1	2	IL6, GCK
19p1	2	INSR, RETN
20q1	2	PTPN1, HNF4A

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
20q	2	PTPN1, HNF4A
2q	4	GPD2, IRS1, NEUROD1, CAPN10
3q	2	SLC2A2, IGF2BP2
19p	2	INSR, RETN
6p	2	HMGA1, CDKAL1
13q	2	IRS2, PDX1
11p	3	MAPK8IP1, ABCC8, KCNJ11
7q	2	PPP1R3A, PAX4
7p	2	IL6, GCK
17q	2	HNF1B, GCGR

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	4	MAPK8IP1, MTNR1B, KCNJ11, ABCC8
13	2	IRS2, PDX1
17	3	HNF1B, SLC2A4, GCGR
19	3	INSR, RETN, AKT2
20	2	PTPN1, HNF4A
3	3	SLC2A2, IGF2BP2, PPARG
2	4	GPD2, IRS1, NEUROD1, CAPN10
7	4	PPP1R3A, PAX4, GCK, IL6
6	3	HMGA1, CDKAL1, ENPP1

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
HMGA1	YES	17	PTGS2, SP1, CXCL1, XPA, POU1F1, INSR, CRYAB, CDC25A, TWIST1, IL1B, CDH1, CD44, TP53, RAG2, SLC2A3, BRCA1, KL	1	INSR
HNF1A	YES	26	GPR39, FABP1, CYP1A2, NT5E, SLC22A9, ALB, SLCO1B3, UGT2B7, UGT2B17, SLC22A10, APOM, CDH17, IGFBP1, TM4SF1, CRP, UGT1A1, UGT1A8, LCT, UGT1A7, AKR1C4, UGT1A10, ACAT2, UGT1A9, AFP, CSRP1, MTTP	0
PAX4	YES	3	INS, GCG, ISL1	0
NEUROD1	YES	3	INS, INSM1, MGAT5B	0
PPARG	YES	69	BCL2L1, EGFR, PLIN2, TNFRSF11B, CPT1B, DEFB103A, NOTCH4, VLDLR, SAT1, TP53, DBI, CAV1, CIDEA, PDK2, SERPINE1, CFLAR, ATP2A2, STAT6, ICAM1, TXNIP, FABP4, PTGS2, JAG1, CCNE1, GDF15, CEBPA, KLF5, GK, APOBR, ERO1L, RETN, CD83, TG, AGER, CAT, CSF1, POU2F1, BCL2, REN, UGT1A9, CDKN1A, CLDN2, ERP44, RARB, ANGPTL4, ADIPOQ, SOCS7, PTEN, BAD, SLC2A4, FGF1, SLC9A1, CD36, ABCG2, MMP1, BRS3, NR1H3, TSHR, LIPE, SLC5A5, ACAT1, MMP9, APOB, HMOX1, CIITA, MYC, CCND1, KLF4, FASLG	2	SLC2A4, RETN
HNF4A	YES	43	GPR39, TBP, CYP2C9, CEACAM1, KCNJ11, LDLR, SHBG, APOA1, UGT2B7, MMP7, CYP7A1, HNF1A, ABCC6, SERPINC1, GH1, PCSK9, CYP2B6, NR1I2, CYP2D6, ABCG8, PPARA, APOB, ABCG5, CDKN1A, AFP, CYP27A1, ACMSD, SLC26A3, RNASE2, SLC22A6, UGT1A7, AKR1C4, GCK, NPC1L1, C1QTNF5, APOA2, APOC3, ACAT2, CYP2C8, FABP2, GFER, MYC, LIPC	4	KCNJ11, HNF1A, LIPC, GCK
TCF7L2	YES	9	PTGS2, STAT3, ABCB1, STARD7, GLCE, BIRC5, HECA, ACVRL1, SNAI2	0
PDX1	YES	3	INS, SLC2A2, GCK	2	SLC2A2, GCK
FOXO1	NO	19	STAT3, RAG1, EDN1, CDKN1B, FABP4, TNFSF10, LHB, NKX6-1, CXCR4, IL6, EGR1, PRL, NEUROG3, HYOU1, TXNIP, IRS2, ADIPOR1, KLF2, IGFBP1	2	IL6, IRS2
MAFA	NO	7	PDX1, PCSK1, PC, INS, GLP1R, SLC2A2, NKX6-1	2	PDX1, SLC2A2
XBP1	NO	19	ERN1, NOS2, FOXO1, CXCL8, ESR1, EDEM2, ZHX2, GAD1, NPPB, HSPA1A, CCL2, IL6, WFS1, PRNP, PTGER4, ERP29, HSPA5, VEGFA, SOD2	2	IL6, WFS1
CEBPB	NO	60	GADD45G, BCL2L1, IRF4, GOT1, PRL, DDIT3, CDKN1A, SMAD4, S100A9, SAA2, PTPN13, MMP1, F8, IL5RA, TFF3, ADM, CYP19A1, INSR, SFTPD, IL6, STAR, TNF, SMAD3, PCK2, IL1B, GNLY, FURIN, SAA1, SLC19A1, PTGS2, XBP1, HSF1, PRDM1, TNFAIP6, HP, IL24, IL10, SLC10A1, DAPK1, CSH2, OXTR, IL13, MAD1L1, CRP, CXCL8, SLC5A8, CSH1, HBB, ASNS, ALB, CSF3R, IL5, IL3, PRSS50, ABCB1, TOP1, GFER, IL4, CSRP1, FASLG	2	IL6, INSR
CEBPA	NO	50	FN1, PRL, CXCR2, VLDLR, SLC2A4, TLR9, S100A9, CSF3R, MSR1, CSF1, AFP, ICAM1, SFTPD, ITGAX, INSR, HAMP, ELANE, STAR, SOCS3, DEFA1, CSF2RA, ID1, CYP3A4, SAA1, HOMER3, IGF1, GAPDH, PCK1, SLC10A1, CD163, SPP1, IL10, DEFA3, PCK2, F9, MAD1L1, SERPINC1, CDK2, BCL2, IL3, HSPA4, ALB, IGF2, IL5, IL6, HSD17B11, CRMP1, MYC, LEP, PRTN3	3	IL6, SLC2A4, INSR
STAT1	NO	79	CFTR, IFNG, NOS2, MET, TP53, CTSB, STRA13, TNFSF13B, S100A10, FCGR1A, FGF2, NOX1, EGFR, IL1B, GAST, ICAM1, TBX21, MVP, PTGS2, FGFR3, OPRM1, STAT2, XAF1, IRF8, HMOX1, FAS, UPP1, CXCL9, IRF7, PIM1, SOCS1, EDN1, KRT17, TLR3, IRF1, IL27, CEBPD, CTSL, CCL2, CDKN1A, IFNB1, CXCL10, CEBPE, PSMB9, FOXP3, IFNA1, NR1H4, FCGRT, TAP1, EGR1, HSP90AA1, PDCD1, JAK2, IVL, IL2RA, CD40, CCL3, CCR1, GLS, STAT3, MMP9, BAX, CD40LG, CD86, IL1R1, SCARB1, NOX4, NOX5, ACAT1, IL6, MUC4, MMP13, LY96, IFIT3, CD22, CIITA, IFNLR1, PPARG, PML	2	IL6, PPARG
EGR1	NO	90	ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG	2	IL6, PPARG
USF2	NO	42	PF4, FCER1A, CTSB, IGF2R, NR5A1, CEACAM1, MYH9, TRAP, ASPH, CEACAM5, TOP3A, PTGS2, PDX1, CYP19A1, HOXB4, THBS1, CFTR, TCN2, TGFB1, PKLR, FMR1, SLC19A1, APC, CD2, TGFB2, PIGR, CTSD, ASCL2, PTPN6, CXCR4, BRCA1, FBP1, BRCA2, CXCR2, ATP5A1, APOA2, APOA5, B2M, HMOX1, TERT, ABCA1, LIPC	2	PDX1, LIPC
USF1	NO	58	PF4, FCER1A, CEACAM5, FMO3, ID4, SCN9A, ASCL2, CEACAM1, MYH9, AGT, APOA2, SERPINE1, TBX21, TOP3A, PTGS2, CYP19A1, ISG20, GCK, CTSB, CXCR4, EXT1, TCN2, SLC22A2, TGFB1, PKLR, FMR1, SLC19A1, APC, SLC16A1, TYMS, CCNB1, TGFB2, PIGR, CYP1A1, CTSD, HOXB7, TRAP, IFNG, PTPN6, NPHS2, GATA5, FBP1, S100A6, BRCA2, HOXB4, ABCA1, SERBP1, TERT, ASPH, APOA5, B2M, HMOX1, CD2, CIITA, APEX1, PTGDS, SLC1A3, LIPC	2	GCK, LIPC
RELA	NO	302	NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC6	3	IL6, IGF2BP2, AKT2
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	7	SLC2A2, INSR, RETN, IL6, HMGA1, IRS2, HNF4A
HMGA2	NO	5	HNF4A, IGF2BP2, SNAI1, POU1F1, CDH1	2	IGF2BP2, HNF4A
RXRA	NO	17	IL2RA, HSD17B2, SERPINC1, ABCC3, IL2RG, CPT1B, ABCB11, THBD, IL2RB, CGB, GNRH2, NOL7, HNF1A, CXCR5, ABCA1, CYP3A4, HNF4A	2	HNF1A, HNF4A
NFKB1	NO	306	NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC6	3	IL6, IGF2BP2, AKT2
TP53	NO	159	ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING1	2	TCF7L2, HNF4A
E2F1	NO	123	WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B	2	HMGA1, PPARG
SREBF2	NO	20	ABCG5, ACOT7, LRP1, NPC1L1, FABP6, FAS, ABCA1, FDFT1, PCSK9, LDLR, PRSS8, HMGCR, FDPS, PON2, ABCG8, HNF4A, MTTP, PPARG, PON1, LIPC	3	PPARG, HNF4A, LIPC
SREBF1	NO	27	AR, FABP6, LPIN1, BCL2L1, CAV1, ACACB, SCD, THRSP, CIC, PDX1, SCD5, FAS, PCSK9, LDLR, FDPS, LRP1, IRS2, PCK1, FDFT1, HK2, NR0B2, ACLY, FASN, APOA5, CETP, HMOX1, PPARG	3	PDX1, PPARG, IRS2
AR	NO	83	UGT2B15, PTPN1, CDH11, AKR1C3, USP26, FOLH1, CCR2, CDK20, CDK6, PNRC1, ARG1, XIAP, VIM, ARG2, EGFR, CFLAR, ETV1, BSG, IGF1R, MUC1, WEE1, PTGS2, NKX3-1, AKT1, NRAS, CDH1, EP300, KLF5, ACTA1, CLK3, FN1, TNF, PRL, ERBB2, ERBB3, CRISP3, CTNNB1, PTEN, CRISP1, SERPINB5, TSC2, NAT1, CDKN1A, GREB1, SEPT7, IFI16, PIGR, KLK3, PC, STIM1, SRD5A3, TCF7L2, JUN, TMPRSS2, RELA, TJP1, BTG1, VEGFA, NFKB1, HMMR, FKBP5, KLK4, CRH, CDH2, BTG2, TGFA, SESN1, CDC6, TH, ALDH1A3, KISS1, KISS1R, PEBP1, KLK2, ATAD2, HMOX1, TSC1, WNT7B, PEG10, TRPS1, CCND1, PIP, FOXA1	2	PTPN1, TCF7L2

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
HMGA1	YES	2	SP1, E2F1	0
LIPC	YES	4	HNF4A, SREBF2, USF1, USF2	1	HNF4A
SLC2A2	YES	4	SP1, MAFA, PDX1, HMGN3	1	PDX1
INSR	YES	5	CEBPB, SP1, HMGA1, ESR2, CEBPA	1	HMGA1
RETN	YES	3	SP1, PPARG, ATF2	1	PPARG
HNF1A	YES	2	RXRA, HNF4A	1	HNF4A
KCNJ11	YES	1	HNF4A	1	HNF4A
IRS2	YES	8	SP1, EIF2AK2, DLX5, FOXO1, SREBF1, NFIC, ZNF148, PGR	0
GCK	YES	5	HNF4A, HIF1A, PDX1, PAX6, USF1	2	PDX1, HNF4A
AKT2	YES	3	NFKB1, RELA, TWIST1	0
GCGR	YES	1	ECD	0
PTPN1	YES	1	AR	0
IGF2BP2	YES	3	HMGA2, NFKB1, RELA	0
NEUROD1	YES	1	NEUROG3	0
PPARG	YES	14	NCOR1, UHRF1, SREBF1, EGR1, SREBF2, CDX1, RB1, CEBPD, SIRT1, NR4A3, KLF2, E2F1, GATA2, STAT1	0
SLC2A4	YES	6	MEF2A, CEBPA, SLC2A4RG, HDAC4, HDAC5, PPARG	1	PPARG
HNF4A	YES	10	SP1, NR1I3, SREBF2, SOX17, TP53, HHEX, RARA, NR0B1, HMGA2, RXRA	0
TCF7L2	YES	2	AR, TP53	0
CAPN10	YES	1	RUNX3	0
IL6	YES	29	OTX2, TBP, ATF4, DDIT3, JUND, REL, SP1, EGR1, EP300, KLF4, CREB1, ZMYND11, FOXO1, PPARA, XBP1, ZNF300, VDR, JUN, RELA, NFKB1, AHR, STAT1, STAT3, CEBPA, RBPJ, CEBPB, GBX2, MYC, ZFP36	0
PDX1	YES	7	ATF3, BTG2, SREBF1, USF2, MAFA, KLF11, ATF6	0
WFS1	YES	1	XBP1	0
PTGS2	NO	41	AR, ING4, TFAP2A, TCF7L2, CREB1, PGR, JUND, FOS, NFATC4, SP1, ETV4, STAT2, EGR1, STAT6, USF2, DR1, CTNNB1, HMGA1, PPARA, APC, EP300, HDAC1, STAT3, ATF2, JUN, RELA, HDAC4, SETBP1, NFKB1, STAT1, ELF3, NR0B2, CREBBP, NFIL3, CDX1, CEBPB, CEBPD, CDX2, JUNB, PPARG, USF1	3	HMGA1, TCF7L2, PPARG
GPR39	NO	3	SP1, HNF1A, HNF4A	2	HNF1A, HNF4A
MYC	NO	66	E2F4, LEF1, PGR, FOXM1, TBP, FUBP1, TP53, MYBL2, SMAD4, MXI1, MYB, AATF, ZNF382, FOS, ZBTB7A, SP1, E2F5, RBL1, TCF4, TBL1X, EP300, SMAD7, HDAC3, TCF3, SRSF1, SMAD3, CNBP, TLX1, ESR1, SIRT1, WT1, APC, CTNNB1, CEBPE, PRDM1, IFI16, DLX5, HDAC10, ZNF300, JUN, ETS2, RELA, BCL6, NFKB1, BRCA1, E2F1, STAT3, HDAC11, CEBPA, HOXA1, PTTG1, PPARG, YY1, MTA1, HDAC2, NF1, SNIP1, RUNX3, RB1, CTCF, ENO1, BDP1, AHR, STAT4, RFX1, HNF4A	2	PPARG, HNF4A
UGT2B7	NO	4	NFE2L2, HNF1A, POU2F1, HNF4A	2	HNF1A, HNF4A
CDKN1A	NO	118	ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING1	2	PPARG, HNF4A
AKR1C4	NO	3	HNF4G, HNF1A, HNF4A	2	HNF1A, HNF4A
APOB	NO	6	PPARA, NR2F6, NR2F1, HNF4A, PPARG, FOXA1	2	PPARG, HNF4A
AFP	NO	11	ZFHX3, HNF1A, CEBPA, ING1, TP53, SIRT2, NF1, ZHX2, NANOG, HNF4G, HNF4A	2	HNF1A, HNF4A
TP53	NO	50	ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN	2	HMGA1, PPARG
ACAT2	NO	3	HNF1A, HNF4A, CDX2	2	HNF1A, HNF4A
INS	NO	9	GLIS3, PAX4, NEUROD1, NR1H4, KLF11, PDX1, TCF3, MAFA, ATF2	3	PAX4, NEUROD1, PDX1
UGT1A9	NO	3	HNF1A, PPARG, PPARA	2	HNF1A, PPARG
UGT1A7	NO	2	HNF1A, HNF4A	2	HNF1A, HNF4A

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
HMGA1	SLC2A2	No	1	APP
HMGA1	INSR	No	1	SYNCRIP
HMGA1	GPD2	No	1	CUL7
HMGA1	PPP1R3A	No	1	PPP1R8
HMGA1	HNF1B	No	1	CREB1
HMGA1	HNF1A	No	4	KAT2B, HMGB1, ANXA2, CREBBP
HMGA1	IRS2	No	1	SRPK2
HMGA1	AKT2	No	4	APP, HSP90AA1, RACGAP1, AP4M1
HMGA1	PTPN1	No	2	CSNK2A1, ATF2
HMGA1	IGF2BP2	No	4	PA2G4, HNRNPD, HNRNPA1, FN1
HMGA1	MAPK8IP1	No	2	JUN, APP
HMGA1	NEUROD1	No	1	HTT
HMGA1	PPARG	Yes	11	SP1, NCOR2, NFKB1, CREBBP, XRCC6, CEBPB, JUN, PRKCA, UBE2I, PPARG, APP
HMGA1	SLC2A4	No	1	HSP90AA1
HMGA1	HNF4A	No	5	SP1, NCOR2, UBE2I, CREBBP, TP53
HMGA1	IRS1	No	2	HDAC2, APP
HMGA1	TCF7L2	No	3	PARP1, UBE2I, XRCC6
HMGA1	PDX1	No	1	XRCC6
LIPC	AKT2	No	1	APOB
LIPC	MAPK8IP1	No	1	LRP1
SLC2A2	AKT2	No	1	APP
SLC2A2	MAPK8IP1	No	1	APP
SLC2A2	PPARG	No	1	APP
SLC2A2	IRS1	No	1	APP
INSR	GPD2	No	1	NTRK1
INSR	IRS2	Yes	9	PTPN11, PLCG1, IRS1, GRB10, SOCS1, SOCS3, NTRK1, GRB2, JAK1
INSR	ENPP1	Yes	2	PON2, SQSTM1
INSR	AKT2	No	3	SNX27, CSK, TMEM17
INSR	PTPN1	Yes	8	CAV1, TMEM17, STAT5A, IRS1, STAT5B, JAK2, NTRK1, GRB2
INSR	MAPK8IP1	No	1	SOCS3
INSR	PPARG	No	6	PRKAA2, PRKAA1, MAPK1, STAT5A, SMAD2, CAV1
INSR	HNF4A	No	2	MAPK1, MAPK3
INSR	IRS1	Yes	12	PTPN11, PRKCD, PTPN1, SH2B1, JAK1, SOCS3, KHDRBS1, GRB10, SOCS1, JAK2, IRS2, GRB2
INSR	CDKAL1	No	1	TMEM17
GPD2	IRS2	No	1	NTRK1
GPD2	PTPN1	No	2	NTRK1, SLC39A4
GPD2	CDKAL1	No	1	FAF2
PPP1R3A	PPARG	No	1	ZFYVE9
HNF1B	HNF1A	Yes	2	HNF1A, PCBD1
HNF1B	AKT2	No	1	HIST1H3A
HNF1B	HNF4A	No	1	PCBD1
HNF1A	KCNJ11	No	2	LDHA, YWHAB
HNF1A	IRS2	No	5	YWHAE, SIRT1, YWHAG, YWHAB, YWHAZ
HNF1A	AKT2	No	1	VIM
HNF1A	PTPN1	No	1	STAT3
HNF1A	NEUROD1	No	1	EP300
HNF1A	PPARG	No	6	CREBBP, NCOA3, NCOA1, YWHAG, EP300, YWHAB
HNF1A	HNF4A	No	4	PCBD1, CREBBP, NCOA1, SIRT1
HNF1A	IRS1	No	3	YWHAE, SIRT1, YWHAB
HNF1A	TCF7L2	No	1	EP300
KCNJ11	IRS2	No	1	YWHAB
KCNJ11	PPARG	No	1	YWHAB
KCNJ11	IRS1	No	1	YWHAB
KCNJ11	ABCC8	Yes	0
IRS2	ENPP1	No	1	INSR
IRS2	AKT2	No	2	ESR1, EGFR
IRS2	PTPN1	No	6	TYK2, INSR, IRS1, EGFR, NTRK1, GRB2
IRS2	IGF2BP2	No	1	ELAVL1
IRS2	MAPK8IP1	No	2	SOCS3, EGFR
IRS2	PPARG	No	5	YWHAG, EGFR, XPO1, NEDD4, YWHAB
IRS2	HNF4A	No	2	SIRT1, XPO1
IRS2	IRS1	Yes	23	UBTF, YWHAE, PTPN11, NISCH, SOCS3, EGFR, YWHAB, INSR, YWHAH, PIK3R1, PIK3CA, SOCS1, SIRT1, ESR1, PIK3R3, BCL2, RPTOR, DVL2, GRB10, JAK1, SFN, GRB2, NEDD4
IRS2	TCF7L2	No	1	ELAVL1
IRS2	CDKAL1	No	1	ELAVL1
ENPP1	PTPN1	No	3	DLG4, HERC2, INSR
ENPP1	IRS1	No	1	INSR
ENPP1	PDX1	No	1	DLG4
AKT2	PTPN1	No	4	GSK3B, SNAI1, TMEM17, EGFR
AKT2	MAPK8IP1	No	2	EGFR, APP
AKT2	PPARG	No	2	EGFR, APP
AKT2	SLC2A4	No	1	HSP90AA1
AKT2	IRS1	No	5	PIK3CB, ESR1, CHUK, EGFR, APP
AKT2	PDX1	No	1	PRKDC
AKT2	CDKAL1	No	1	TMEM17
PTPN1	MAPK8IP1	No	1	EGFR
PTPN1	PPARG	No	5	CAV1, STAT5A, EGFR, CTNNB1, PHB2
PTPN1	SLC2A4	No	1	MVP
PTPN1	HNF4A	No	1	CTNNB1
PTPN1	IRS1	Yes	5	JAK2, IGF1R, INSR, GRB2, EGFR
PTPN1	TCF7L2	No	1	CTNNB1
PTPN1	CAPN10	No	1	FLOT1
PTPN1	PDX1	No	1	DLG4
PTPN1	WFS1	No	2	TCTN3, LYPD3
PTPN1	CDKAL1	No	5	TCTN3, TMEM216, TMEM17, TCTN2, EVC2
IGF2BP2	TCF7L2	No	1	ELAVL1
IGF2BP2	CDKAL1	No	1	ELAVL1
MAPK8IP1	NEUROD1	No	1	MAP3K10
MAPK8IP1	PPARG	No	3	JUN, EGFR, APP
MAPK8IP1	IRS1	No	6	MAPK8, EGFR, SOCS3, ERBB2, AKT1, APP
NEUROD1	PPARG	No	4	NR0B2, EP300, SMARCA4, TCF4
NEUROD1	HNF4A	No	1	NR0B2
NEUROD1	TCF7L2	No	1	EP300
NEUROD1	PDX1	No	1	MAFA
PPARG	SLC2A4	No	1	SERPINH1
PPARG	HNF4A	No	24	NRIP1, NCOA6, MED24, XPO1, SP1, MDM2, NCOR2, HDAC3, COPS5, NCOA2, SMAD3, PPARGC1A, CTNNB1, VDR, ZNHIT3, MED1, NCOA1, HDAC4, UBE2I, MED14, NR0B2, CREBBP, MAPK1, PPARGC1B
PPARG	IRS1	No	7	IKBKB, SMAD3, NEDD4, EGFR, UBC, YWHAB, APP
PPARG	TCF7L2	No	6	PML, XRCC6, CTNNB1, UBE2I, EP300, XRCC5
PPARG	PDX1	No	2	XRCC6, XRCC5
SLC2A4	TCF7L2	No	1	DAXX
HNF4A	IRS1	No	2	SMAD3, SIRT1
HNF4A	TCF7L2	No	3	UBE2I, AR, CTNNB1
IRS1	PDX1	No	1	ALK
TCF7L2	PDX1	No	2	XRCC6, XRCC5
TCF7L2	CDKAL1	No	1	ELAVL1
WFS1	CDKAL1	No	1	TCTN3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
HMGA1	SLC2A2	No	-	2	INS, INSR
HMGA1	INSR	Yes	binding, activation, expression	4	INS, UBC, RPS6KB1, KITLG
HMGA1	PPP1R3A	No	-	2	INS, INSR
HMGA1	RETN	No	-	3	SP1, INS, INSR
HMGA1	HNF1B	No	-	1	CREBBP
HMGA1	HNF1A	No	-	3	INS, MYC, CREBBP
HMGA1	IRS2	No	-	3	INS, PPARG, INSR
HMGA1	GCK	No	-	2	INS, CREBBP
HMGA1	ENPP1	No	-	1	INSR
HMGA1	PAX4	No	-	1	INS
HMGA1	AKT2	No	-	6	CDKN1A, INSR, INS, RPS6KB1, ESR1, UBC
HMGA1	PTPN1	No	-	2	INS, INSR
HMGA1	IGF2BP2	No	-	1	UBC
HMGA1	NEUROD1	No	-	2	INS, TP53
HMGA1	PPARG	Yes	binding	8	SP1, CREBBP, RPS6KB1, TP53, INS, RB1, ESR1, UBC
HMGA1	SLC2A4	No	-	5	INS, UBC, UBE2I, PPARG, TP53
HMGA1	HNF4A	No	-	9	SP1, TBP, PPARG, CREBBP, TP53, JUN, ESR1, MYC, HIPK2
HMGA1	IRS1	No	-	6	INSR, JUN, INS, RPS6KB1, ESR1, UBC
HMGA1	TCF7L2	No	-	4	INS, CREBBP, MYC, JUN
HMGA1	CAPN10	No	-	2	INS, PPARG
HMGA1	IL6	No	-	8	SP1, CDKN1A, TP53, INS, JUN, ESR1, UBC, MYC
HMGA1	ABCC8	No	-	1	INS
HMGA1	PDX1	No	-	4	UBC, SP1, HIPK2, INS
HMGA1	WFS1	No	-	1	UBC
HMGA1	CDKAL1	No	-	1	UBC
LIPC	PPARG	No	-	1	APOE
LIPC	IL6	No	-	2	APOB, APOE
SLC2A2	INSR	Yes	activation, binding	1	INS
SLC2A2	PPP1R3A	No	-	2	INS, INSR
SLC2A2	RETN	No	-	3	INS, LEP, INSR
SLC2A2	HNF1A	Yes	activation, binding	1	INS
SLC2A2	KCNJ11	No	-	1	FOXA2
SLC2A2	IRS2	No	-	4	INS, LEP, IGF1R, INSR
SLC2A2	GCK	No	-	2	INS, FOXA2
SLC2A2	ENPP1	No	-	1	INSR
SLC2A2	PAX4	No	-	2	INS, GCG
SLC2A2	AKT2	No	-	3	INS, FOXA2, INSR
SLC2A2	GCGR	No	-	1	GCG
SLC2A2	PTPN1	No	-	4	INS, LEP, IGF1R, INSR
SLC2A2	MAPK8IP1	Yes	expression, binding	0
SLC2A2	NEUROD1	No	-	1	INS
SLC2A2	PPARG	No	-	2	INS, LEP
SLC2A2	SLC2A4	No	-	3	INS, LEP, GCG
SLC2A2	HNF4A	No	-	2	HNF1A, FOXA2
SLC2A2	IRS1	No	-	5	INS, LEP, FOXA2, IGF1R, INSR
SLC2A2	TCF7L2	No	-	2	INS, GCG
SLC2A2	CAPN10	No	-	1	INS
SLC2A2	IL6	No	-	2	INS, LEP
SLC2A2	ABCC8	No	-	2	INS, FOXA2
SLC2A2	PDX1	No	-	4	INS, HNF1A, FOXA2, GCG
INSR	PPP1R3A	Yes	activation	2	INS, PPP1CC
INSR	RETN	Yes	binding, activation, expression	5	IGF1, INS, AKT1, PTEN, SOCS3
INSR	HNF1A	No	-	3	INS, SLC2A2, IGF1
INSR	KCNJ11	No	-	1	HSP90AA1
INSR	IRS2	Yes	activation	28	PLCG1, DOK1, PTPRF, YWHAE, PTPN1, JAK2, SOCS3, AKT1, CRK, SOCS2, SOCS4, PIK3R1, PIK3CA, IRS4, SOCS1, SOS1, INPP5D, HRAS, HSP90AA1, PIK3R3, MAPK3, IRS1, INS, PRKCD, JAK1, IGF1, GRB2, PTPN11
INSR	GCK	No	-	2	INS, INPPL1
INSR	ENPP1	Yes	activation, binding	3	FGF23, FGF2, FGF13
INSR	PAX4	No	-	1	INS
INSR	AKT2	Yes	activation, binding	15	PIK3R3, BCL2L1, PHLPP2, AKT1, PHLPP1, HRAS, INPPL1, PIK3CA, INS, PDPK1, RPS6KB1, HSP90AA1, PTEN, GRB14, UBC
INSR	GCGR	No	-	1	FGF21
INSR	PTPN1	Yes	activation, binding	25	IRS4, JAK2, CAV1, PDGFB, AKT1, CRK, JAK1, PIK3CA, STAT5A, CSF1, SHC1, NCK2, IGF1, HGF, ADIPOQ, DOK1, GRB14, NCK1, STAT5B, IRS1, INS, PIK3R1, IRS2, EGF, GRB2
INSR	IGF2BP2	No	-	1	UBC
INSR	MAPK8IP1	No	-	2	SLC2A2, AKT1
INSR	NEUROD1	No	-	1	INS
INSR	PPARG	No	-	10	AR, IRS2, ADIPOQ, STAT5A, INS, RPS6KB1, HMGA1, PTEN, UBC, VEGFA
INSR	SLC2A4	No	-	7	IGF1, PRKCI, YWHAE, PRKCZ, INS, AKT1, UBC
INSR	HNF4A	No	-	1	AR
INSR	IRS1	Yes	activation, binding	43	BCL2L1, AKT1, ANXA2, YWHAE, PTPN1, JAK2, CAV1, SOS1, SOCS2, CRKL, INS, CRK, SOCS4, JAK1, PIK3CA, SOCS3, IRS4, KHDRBS1, SHC1, INPP5D, NCK2, IRS2, SH2B1, HRAS, RPS6KB1, DOK1, PIK3R3, GRB14, VEGFA, SOCS1, NCK1, SOCS7, CBL, MAPK3, SORBS1, GRB10, PRKCD, PIK3R1, PTPRF, IGF1, UBC, GRB2, PTPN11
INSR	TCF7L2	No	-	2	INS, AR
INSR	CAPN10	No	-	1	INS
INSR	IL6	No	-	29	BCL2L1, AR, JAK2, SOS1, PGF, FGF2, PTPN2, HSP90AA1, ANGPT1, STAT5A, SOCS3, SOCS1, SHC1, HGF, PTPN1, VAV1, ADIPOQ, GRB2, AKT1, VEGFA, GAB1, STAT5B, IRS1, INS, JAK1, IGF1, UBC, VEGFC, PTPN11
INSR	ABCC8	No	-	2	INS, HSP90AA1
INSR	PDX1	No	-	3	UBC, INS, FGF10
INSR	WFS1	No	-	1	UBC
INSR	CDKAL1	No	-	1	UBC
GPD2	PPARG	No	-	1	GPD1
PPP1R3A	RETN	No	-	2	INS, INSR
PPP1R3A	HNF1A	No	-	1	INS
PPP1R3A	IRS2	No	-	2	INS, INSR
PPP1R3A	GCK	No	-	1	INS
PPP1R3A	ENPP1	No	-	1	INSR
PPP1R3A	PAX4	No	-	1	INS
PPP1R3A	AKT2	No	-	3	INS, GSK3B, INSR
PPP1R3A	PTPN1	No	-	2	INS, INSR
PPP1R3A	NEUROD1	No	-	1	INS
PPP1R3A	PPARG	No	-	1	INS
PPP1R3A	SLC2A4	No	-	2	INS, GSK3B
PPP1R3A	IRS1	No	-	3	INS, GSK3B, INSR
PPP1R3A	TCF7L2	No	-	1	INS
PPP1R3A	CAPN10	No	-	1	INS
PPP1R3A	IL6	No	-	1	INS
PPP1R3A	ABCC8	No	-	1	INS
PPP1R3A	PDX1	No	-	1	INS
RETN	HNF1A	No	-	4	INS, FOS, IGF1, SIRT1
RETN	IRS2	No	-	8	IGF1, INSR, GH1, SOCS3, INS, AKT1, LEP, PPARA
RETN	GCK	No	-	1	INS
RETN	ENPP1	No	-	1	INSR
RETN	PAX4	No	-	1	INS
RETN	AKT2	No	-	5	INS, NOS3, INSR, AKT1, PTEN
RETN	MTNR1B	No	-	2	CXCL12, NPY
RETN	GCGR	No	-	1	EDN1
RETN	PTPN1	No	-	6	IGF1, INSR, GH1, INS, AKT1, LEP
RETN	MAPK8IP1	No	-	1	AKT1
RETN	NEUROD1	No	-	1	INS
RETN	PPARG	No	-	13	SP1, CD36, CEBPA, SERPINE1, PPARA, SPP1, INS, UCP1, PTEN, LEP, FOS, SIRT1, PNPLA2
RETN	SLC2A4	No	-	6	IGF1, CEBPA, GH1, INS, AKT1, LEP
RETN	HNF4A	No	-	3	SP1, PPARA, SIRT1
RETN	IRS1	No	-	10	AKT1, INSR, GH1, STK11, SOCS3, INS, UCP1, IGF1, LEP, SIRT1
RETN	TCF7L2	No	-	2	INS, FOS
RETN	CAPN10	No	-	1	INS
RETN	IL6	No	-	16	SP1, NOS3, UCP1, AKT1, SERPINE1, PPARA, CXCL12, STK11, SOCS3, INS, EDN1, IGF1, LEP, FOS, NPY, TLR2
RETN	ABCC8	No	-	1	INS
RETN	PDX1	No	-	2	SP1, INS
HNF1B	HNF1A	No	-	4	ONECUT1, PCBD1, CREBBP, DPP4
HNF1B	GCK	No	-	1	CREBBP
HNF1B	PPARG	No	-	1	CREBBP
HNF1B	HNF4A	No	-	2	ONECUT1, CREBBP
HNF1B	TCF7L2	No	-	1	CREBBP
HNF1B	PDX1	No	-	1	ONECUT1
HNF1A	IRS2	No	-	4	INS, MAPK8, IGF1, CDX2
HNF1A	GCK	No	-	5	INS, PDX1, EP300, CREBBP, HNF4A
HNF1A	PAX4	No	-	1	INS
HNF1A	AKT2	No	-	2	INS, CTNNB1
HNF1A	GCGR	No	-	2	IAPP, HNF4A
HNF1A	PTPN1	No	-	6	STAT3, IGF1, MAPK1, INS, CTNNB1, SRC
HNF1A	MAPK8IP1	No	-	2	MAPK8, SLC2A2
HNF1A	NEUROD1	No	-	3	INS, CCND1, EP300
HNF1A	PPARG	No	-	12	CREBBP, MAPK8, EP300, HDAC1, FABP1, NLK, INS, SIRT1, HNF4G, FOS, PPARD, HNF4A
HNF1A	SLC2A4	No	-	4	NR5A2, INS, MAPK8, IGF1
HNF1A	HNF4A	Yes	activation, binding	11	MYC, MAPK8, CTNNB1, CCND1, CREBBP, SMAD4, ONECUT1, CDX2, HNF4G, PPARD, SIRT1
HNF1A	IRS1	No	-	7	STAT3, MAPK1, MAPK8, INS, IGF1, SRC, SIRT1
HNF1A	TCF7L2	No	-	13	CREBBP, EP300, CTBP1, HDAC1, SMAD4, INS, AES, NLK, CTNNB1, MYC, CCND1, FOS, TLE1
HNF1A	CAPN10	No	-	1	INS
HNF1A	IL6	No	-	9	STAT3, CCND1, INS, IGF1, SRC, MYC, FOS, CLDN2, IGFBP1
HNF1A	ABCC8	No	-	1	INS
HNF1A	PDX1	Yes	activation, binding	5	INS, NR5A2, ONECUT1, IAPP, NKX6-1
KCNJ11	IRS2	No	-	1	HSP90AA1
KCNJ11	GCK	No	-	1	FOXA2
KCNJ11	AKT2	No	-	3	GAPDH, FOXA2, HSP90AA1
KCNJ11	SLC2A4	No	-	1	GAPDH
KCNJ11	HNF4A	No	-	1	FOXA2
KCNJ11	IRS1	No	-	1	FOXA2
KCNJ11	IL6	No	-	1	HSP90AA1
KCNJ11	ABCC8	Yes	binding	8	RAPGEF4, HSP90AA1, PRKACG, FOXA2, RAPGEF3, PRKACA, KCNJ8, PRKACB
KCNJ11	PDX1	No	-	4	PRKACG, FOXA2, PRKACA, PRKACB
IRS2	GCK	No	-	2	INS, ATF3
IRS2	ENPP1	No	-	1	INSR
IRS2	PAX4	No	-	2	INS, BTC
IRS2	AKT2	No	-	20	PIK3R3, HSP90AA1, KRAS, AKT1, PIK3CG, BCL2, HRAS, IKBKB, PIK3CA, INS, RPTOR, INSR, PIK3CB, CREB1, FOXO1, MTOR, FOXO3, PIK3CD, PIK3R5, CHUK
IRS2	PTPN1	Yes	inhibition, binding	21	TYK2, CRK, EGFR, IGF1, GHR, GH1, IGF1R, JAK1, PIK3CA, INS, JAK2, PIK3R1, INSR, DOK1, IRS1, IRS4, IL4, GRB2, AKT1, LEP, EPOR
IRS2	IGF2BP2	No	-	1	IGF2
IRS2	MAPK8IP1	No	-	3	MAPK8, MAPK10, AKT1
IRS2	NEUROD1	No	-	1	INS
IRS2	PPARG	Yes	activation, binding	10	IL2, IL4, MAPK8, MTOR, INS, RPTOR, CDH1, FOXO1, LEP, PPARA
IRS2	SLC2A4	No	-	12	MAPK8, FOXO1, IGF1, SREBF1, GH1, YWHAH, YWHAE, INS, AKT1, LEP, PPARG, YWHAZ
IRS2	HNF4A	No	-	6	MAPK8, CDX2, SREBF1, PPARG, FOXO1, PPARA
IRS2	IRS1	Yes	activation, binding	56	PIK3R3, PTPN1, PIK3CG, BCL2, PTPRF, GH1, YWHAE, PTPN11, JAK2, MAPK10, INSRR, PIK3R2, EGFR, AKT1, CHUK, MAPK8, INSR, PRKCE, CRK, SOCS2, PIK3R5, SOCS4, JAK1, SOS1, SOCS3, IRS4, IL4, SOCS1, IL4R, LEP, MTOR, YWHAZ, FOXO1, LCK, HRAS, IKBKB, DOK1, GRB2, IL2, KRAS, GHR, RPTOR, FES, IGF1R, MAPK3, PIK3CB, IGF2, INS, PRKCD, PIK3R1, IL2RB, IGF1, PIK3CA, INPP5D, PIK3CD, YWHAH
IRS2	TCF7L2	No	-	1	INS
IRS2	CAPN10	No	-	2	INS, PPARG
IRS2	IL6	No	-	28	TYK2, PTPN1, JAK2, SOS1, EGFR, ATF3, GHR, IL2RB, SOCS3, SOCS1, FOXO1, LEP, PPARA, IL4R, HSP90AA1, IKBKB, AKT1, IL2, IL4, BCL2, MTOR, INS, JAK1, EPOR, IGF1, IRS1, GRB2, PTPN11
IRS2	ABCC8	No	-	2	INS, HSP90AA1
IRS2	PDX1	No	-	3	INS, ATF3, FOXO1
GCK	PAX4	No	-	1	INS
GCK	AKT2	No	-	5	INS, MAP3K8, FOXA2, PFKFB2, INPPL1
GCK	GCGR	No	-	1	HNF4A
GCK	PTPN1	No	-	1	INS
GCK	NEUROD1	Yes	activation, binding	2	INS, EP300
GCK	PPARG	No	-	4	INS, CREBBP, EP300, HNF4A
GCK	SLC2A4	No	-	1	INS
GCK	HNF4A	Yes	activation, binding	3	CREBBP, FOXA2, HIF1A
GCK	IRS1	No	-	2	INS, FOXA2
GCK	TCF7L2	No	-	3	INS, CREBBP, EP300
GCK	CAPN10	No	-	1	INS
GCK	IL6	No	-	2	INS, ATF3
GCK	ABCC8	No	-	2	INS, FOXA2
GCK	PDX1	Yes	activation, binding	3	INS, ATF3, FOXA2
ENPP1	AKT2	No	-	1	INSR
ENPP1	PTPN1	No	-	1	INSR
ENPP1	IRS1	No	-	1	INSR
ENPP1	IL6	No	-	1	FGF2
PAX4	AKT2	No	-	1	INS
PAX4	GCGR	No	-	1	GCG
PAX4	PTPN1	No	-	1	INS
PAX4	NEUROD1	No	-	2	INS, NEUROG3
PAX4	PPARG	No	-	1	INS
PAX4	SLC2A4	No	-	2	INS, GCG
PAX4	IRS1	No	-	1	INS
PAX4	TCF7L2	No	-	2	INS, GCG
PAX4	CAPN10	No	-	1	INS
PAX4	IL6	No	-	1	INS
PAX4	ABCC8	No	-	1	INS
PAX4	PDX1	No	-	2	INS, GCG
AKT2	PTPN1	No	-	7	CTNNB1, INSR, ATF4, PIK3CA, INS, AKT1, GRB14
AKT2	IGF2BP2	No	-	1	UBC
AKT2	MAPK8IP1	No	-	1	AKT1
AKT2	NEUROD1	No	-	2	INS, NR4A1
AKT2	PPARG	No	-	13	AKT1S1, FOXO1, PTEN, RPS6KB1, MTOR, INS, RPTOR, NR4A1, ATF2, ESR1, UBC, TRIB3, FOXA1
AKT2	SLC2A4	No	-	11	STXBP4, AKT1, TBC1D4, GAPDH, RAB14, RHOQ, INS, LNPEP, FOXO1, UBC, GSK3B
AKT2	HNF4A	No	-	6	CTNNB1, SNAI1, FOXA2, FOXO1, NR4A1, ESR1
AKT2	IRS1	No	-	27	BCL2L1, AKT1, RPTOR, FOXA2, PIK3CA, PIK3CG, CHUK, AKT1S1, INSR, PIK3R5, MLST8, KRAS, FOXO1, RPS6KB2, HRAS, RPS6KB1, PIK3CB, PIK3R3, GRB14, GSK3B, BCL2, IKBKB, MTOR, INS, ESR1, UBC, PIK3CD
AKT2	TCF7L2	No	-	4	INS, BTRC, CTNNB1, FOXA1
AKT2	CAPN10	No	-	1	INS
AKT2	IL6	No	-	17	CDKN1A, FOXO1, TBC1D4, HSP90B1, BCL2, ILK, BCL2L1, MTOR, INS, ATF2, IKBKB, KHSRP, HSP90AA1, ESR1, UBC, NOS3, AKT1
AKT2	ABCC8	No	-	3	INS, FOXA2, HSP90AA1
AKT2	PDX1	No	-	4	UBC, INS, FOXA2, FOXO1
AKT2	WFS1	No	-	1	UBC
AKT2	CDKAL1	No	-	1	UBC
MTNR1B	GCGR	No	-	37	GNAQ, GNG2, LPAR2, GNG10, GNG13, FPR2, AGT, BDKRB2, CASR, LPAR3, KNG1, APP, GNG11, ANXA1, POMC, GNG12, GNB1, MCHR2, NMUR1, MTRNR2L2, LPAR5, GNG3, GNG4, GNB2, NMU, GPR17, LPAR1, GNG8, NMS, GNB4, NMUR2, GNG5, SAA1, BDKRB1, PMCH, GNG7, MCHR1
MTNR1B	MAPK8IP1	No	-	2	APP, BDKRB1
MTNR1B	NEUROD1	No	-	1	POMC
MTNR1B	PPARG	No	-	1	CCR2
MTNR1B	SLC2A4	No	-	1	CNR1
MTNR1B	TCF7L2	No	-	1	IL8
MTNR1B	IL6	No	-	15	P2RY12, KNG1, ADORA1, ANXA1, CCR7, IL8, POMC, CXCL12, AGT, PPBP, APLN, CASR, GAL, NPY, APP
MTNR1B	PDX1	No	-	2	SST, SSTR5
GCGR	MAPK8IP1	No	-	3	TRH, APP, BDKRB1
GCGR	NEUROD1	No	-	1	POMC
GCGR	PPARG	No	-	3	ADRB3, HNF4A, AGTR1
GCGR	SLC2A4	No	-	1	GCG
GCGR	HNF4A	Yes	activation, binding	0
GCGR	TCF7L2	No	-	1	GCG
GCGR	IL6	No	-	15	NMB, CRH, CASR, TSHR, ANXA1, VIP, PTH, POMC, EDN1, APP, OXTR, AGT, KNG1, P2RY2, ADORA2B
GCGR	PDX1	No	-	2	IAPP, GCG
PTPN1	MAPK8IP1	No	-	1	AKT1
PTPN1	NEUROD1	No	-	1	INS
PTPN1	PPARG	No	-	8	IL4, STAT5A, NOX4, INS, NFATC2, ADIPOQ, IRS2, LEP
PTPN1	SLC2A4	No	-	5	GH1, INS, LEP, IGF1, AKT1
PTPN1	HNF4A	No	-	1	CTNNB1
PTPN1	IRS1	Yes	binding	35	ITGB3, IRS4, MET, IL4, FN1, JAK2, GRB14, CAV1, EGFR, INSR, CRK, JAK1, PIK3CA, NCK1, SHC1, NCK2, IRS2, CSF1R, DOK1, AKT1, SRC, LEP, PIK3R1, STAT3, PDGFRB, IGF1R, MAPK1, INS, GH1, IL6, IGF1, KDR, GRB2, BCAR1, GHR
PTPN1	TCF7L2	No	-	2	INS, CTNNB1
PTPN1	CAPN10	No	-	1	INS
PTPN1	IL6	Yes	activation, binding	29	TYK2, MET, JAK2, IFNGR2, EGFR, GHR, ERBB2, STAT5A, ADIPOQ, SHC1, IFNAR1, HGF, CSF1R, STAT5B, AKT1, SRC, CNTF, MAPK14, STAT3, KDR, NFATC2, IRS1, INS, JAK1, IGF1, IL4, GRB2, LEP, EPOR
PTPN1	ABCC8	No	-	1	INS
PTPN1	PDX1	No	-	3	INS, MAPK14, EGR1
IGF2BP2	PPARG	No	-	1	UBC
IGF2BP2	SLC2A4	No	-	1	UBC
IGF2BP2	IRS1	No	-	2	UBC, IGF2
IGF2BP2	IL6	No	-	1	UBC
IGF2BP2	PDX1	No	-	1	UBC
IGF2BP2	WFS1	No	-	1	UBC
IGF2BP2	CDKAL1	No	-	1	UBC
MAPK8IP1	PPARG	No	-	1	MAPK8
MAPK8IP1	SLC2A4	No	-	2	MAPK8, AKT1
MAPK8IP1	HNF4A	No	-	1	MAPK8
MAPK8IP1	IRS1	No	-	6	MAPK8, MAPK9, MAPK10, MAPK8IP2, AKT1, FYN
MAPK8IP1	IL6	No	-	2	APP, AKT1
NEUROD1	PPARG	No	-	4	INS, NR4A1, EP300, TP53
NEUROD1	SLC2A4	No	-	2	INS, TP53
NEUROD1	HNF4A	No	-	4	CCND1, NR4A1, TP53, GCK
NEUROD1	IRS1	No	-	1	INS
NEUROD1	TCF7L2	No	-	4	INS, CCND1, EP300, SMARCA4
NEUROD1	CAPN10	No	-	1	INS
NEUROD1	IL6	No	-	4	INS, CCND1, POMC, TP53
NEUROD1	ABCC8	No	-	1	INS
NEUROD1	PDX1	No	-	3	INS, MAFA, GCK
PPARG	SLC2A4	Yes	binding, expression	15	NCOR2, PRKAA2, NRIP1, CEBPA, MAPK8, KLF4, NFE2L2, TP53, INS, HDAC3, UCP3, FOXO1, UBC, LEP, NCOR1
PPARG	HNF4A	Yes	binding	50	RARB, RORC, NCOA6, NR5A1, ESRRG, NR2F1, PGR, NR1H2, RXRG, RORA, NR2C2AP, MAPK8, FOXO1, NR2C2, PPARD, NR2C1, MED25, THRB, NCOR2, RORB, RARG, IL1B, HNF4G, NRBP1, PPARA, SIRT1, SP1, PPARGC1A, NCOA2, THRA, VDR, AR, NR4A2, RARA, ESR2, MED1, NR4A1, TP53, NR2E1, NR0B2, ESRRB, MED14, NR1D1, SREBF2, NR2F6, SCARB1, ESRRA, ESR1, NR1D2, CREBBP
PPARG	IRS1	No	-	17	AKT1S1, FOXO1, IRS2, IL4, MAPK8, RPTOR, MTOR, INS, RPS6KB1, UCP1, ESR1, UBC, IL2, VEGFA, LEP, RARRES2, SIRT1
PPARG	TCF7L2	No	-	14	CREBBP, AR, NR2F2, EP300, ASH2L, HDAC1, HDAC3, NLK, INS, RBBP5, NCOA2, FOS, KLF4, FOXA1
PPARG	CAPN10	Yes	binding	1	INS
PPARG	IL6	No	-	41	AR, RELA, TP53, NFATC2, CCL2, SERPINE1, FOS, VEGFA, PTGS2, INS, RPS27A, FOXO1, IL4, STAT5A, IL1B, TGFB1, LEP, PPARA, ESR1, UCP1, SP1, NCOA2, APOE, ATF2, IL17A, ADIPOQ, CTGF, MTOR, ICAM1, NFKB1, IL2, BMP6, MMP1, PON1, CEBPB, CEBPD, HMOX1, PRKCA, UBC, AHR, ABCA1
PPARG	ABCC8	No	-	1	INS
PPARG	PDX1	No	-	4	SP1, UBC, FOXO1, INS
PPARG	WFS1	No	-	1	UBC
PPARG	CDKAL1	No	-	1	UBC
SLC2A4	HNF4A	No	-	7	MAPK8, SREBF1, GATA6, TP53, NCOR2, FOXO1, PPARG
SLC2A4	IRS1	No	-	13	MAPK8, FOXO1, AKT1, GH1, YWHAH, YWHAE, INS, YWHAB, IGF1, UBC, LEP, GSK3B, YWHAZ
SLC2A4	TCF7L2	No	-	4	INS, HDAC3, KLF4, GCG
SLC2A4	CAPN10	No	-	2	INS, PPARG
SLC2A4	IL6	No	-	10	ATIC, FOXO1, TBC1D4, TP53, INS, IGF1, UBC, CTF1, AKT1, LEP
SLC2A4	ABCC8	No	-	1	INS
SLC2A4	PDX1	No	-	5	UBC, NR5A2, GCG, FOXO1, INS
SLC2A4	WFS1	No	-	1	UBC
SLC2A4	CDKAL1	No	-	1	UBC
HNF4A	IRS1	No	-	6	MAPK8, ESR1, JUN, FOXA2, FOXO1, SIRT1
HNF4A	TCF7L2	No	-	9	AR, NCOA2, LEF1, CCND1, SMAD4, JUN, CTNNB1, MYC, CREBBP
HNF4A	CAPN10	No	-	1	PPARG
HNF4A	IL6	No	-	12	SP1, AR, FOXO1, NCOA2, CCND1, TP53, IL1B, JUN, SERPINA1, ESR1, MYC, PPARA
HNF4A	ABCC8	No	-	1	FOXA2
HNF4A	PDX1	No	-	7	SP1, HNF1A, GCK, ONECUT1, FOXA2, FOXO1, HIPK2
IRS1	TCF7L2	No	-	4	INS, JUN, ID2, YAP1
IRS1	CAPN10	No	-	1	INS
IRS1	IL6	Yes	binding, activation, expression	36	BCL2L1, OSM, MET, PTPN1, JAK2, SOCS3, EGFR, GHR, JAK1, SOS1, SOCS1, FOXO1, SHC1, ESR1, UCP1, IL4R, IL2, CSF1R, JUN, AKT1, SRC, VEGFA, LEP, STAT3, KDR, BCL2, STK11, IKBKB, MTOR, INS, IL2RB, IGF1, IL4, UBC, GRB2, PTPN11
IRS1	ABCC8	No	-	2	INS, FOXA2
IRS1	PDX1	No	-	4	UBC, INS, FOXA2, FOXO1
IRS1	WFS1	No	-	1	UBC
IRS1	CDKAL1	No	-	1	UBC
TCF7L2	CAPN10	No	-	1	INS
TCF7L2	IL6	No	-	12	BIRC5, DKK1, CCND1, AR, IL8, INS, JUN, NCOA2, MYC, FOS, WNT5A, VMP1
TCF7L2	ABCC8	No	-	1	INS
TCF7L2	PDX1	No	-	2	INS, GCG
CAPN10	IL6	No	-	1	INS
CAPN10	ABCC8	No	-	1	INS
CAPN10	PDX1	No	-	1	INS
IL6	ABCC8	No	-	2	INS, HSP90AA1
IL6	PDX1	No	-	7	SP1, NOTCH1, ATF3, INS, FOXO1, UBC, MAPK14
IL6	WFS1	No	-	1	UBC
IL6	CDKAL1	No	-	1	UBC
ABCC8	PDX1	No	-	6	PRKX, INS, PRKACG, FOXA2, PRKACA, PRKACB
PDX1	WFS1	No	-	1	UBC
PDX1	CDKAL1	No	-	1	UBC
WFS1	CDKAL1	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
INSR	IRS1	Yes	Sam68-p85 P13K-IRS-1-IR signaling complex	2	KHDRBS1, PIK3R1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
INSR	PTPN1	Yes	2	PTPN1, INSR
INSR	IRS1	Yes	3	IGF1R, IRS1, INSR
IRS2	GCGR	No	1	B2M
PTPN1	IRS1	No	1	INSR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Type II diabetes mellitus	hsa04930	7.12	9	SLC2A4, ABCC8, SLC2A2, GCK, PDX1, IRS1, KCNJ11, INSR, IRS2
Insulin signaling pathway	hsa04910	5.55	8	AKT2, PPP1R3A, GCK, INSR, PTPN1, SLC2A4, IRS1, IRS2
Maturity onset diabetes of the young	hsa04950	8.07	8	PAX4, NEUROD1, GCK, PDX1, SLC2A2, HNF1A, HNF1B, HNF4A
AMPK signaling pathway	hsa04152	5.8	7	SLC2A4, INSR, AKT2, IRS1, IRS2, PPARG, HNF4A
FoxO signaling pathway	hsa04068	5.63	6	SLC2A4, INSR, AKT2, IRS1, IL6, IRS2
Insulin secretion	hsa04911	6.18	5	PDX1, SLC2A2, KCNJ11, ABCC8, GCK
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51	5	AKT2, IRS2, IL6, IRS1, INSR
cGMP-PKG signaling pathway	hsa04022	5.32	4	IRS2, AKT2, IRS1, INSR
PI3K-Akt signaling pathway	hsa04151	4.21	4	IL6, INSR, AKT2, IRS1
Pathways in cancer	hsa05200	3.98	4	IL6, PPARG, AKT2, TCF7L2
Adipocytokine signaling pathway	hsa04920	6.6	4	IRS2, AKT2, SLC2A4, IRS1
HIF-1 signaling pathway	hsa04066	5.9	3	IL6, AKT2, INSR
Metabolic pathways	hsa01100	2.49	3	ENPP1, LIPC, GCK
Adherens junction	hsa04520	6.26	3	PTPN1, TCF7L2, INSR
Central carbon metabolism in cancer	hsa05230	6.7	3	AKT2, SLC2A2, GCK
Prolactin signaling pathway	hsa04917	6.6	3	AKT2, SLC2A2, GCK
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6	2	AKT2, HNF1A
Endometrial cancer	hsa05213	6.81	2	AKT2, TCF7L2
Colorectal cancer	hsa05210	6.52	2	AKT2, TCF7L2
Thyroid cancer	hsa05216	7.48	2	TCF7L2, PPARG
Prostate cancer	hsa05215	6.11	2	AKT2, TCF7L2
Neurotrophin signaling pathway	hsa04722	5.78	2	AKT2, IRS1
Starch and sucrose metabolism	hsa00500	6.91	2	ENPP1, GCK
Osteoclast differentiation	hsa04380	5.64	2	AKT2, PPARG
Aldosterone-regulated sodium reabsorption	hsa04960	7.41	2	IRS1, INSR
Chagas disease (American trypanosomiasis)	hsa05142	5.99	2	IL6, AKT2
Influenza A	hsa05164	5.21	2	IL6, AKT2
HTLV-I infection	hsa05166	4.59	2	IL6, AKT2
Hepatitis B	hsa05161	5.52	2	IL6, AKT2
Measles	hsa05162	5.6	2	IL6, AKT2
MicroRNAs in cancer	hsa05206	5.38	2	IRS2, IRS1
Toll-like receptor signaling pathway	hsa04620	6.0	2	IL6, AKT2
Transcriptional misregulation in cancer	hsa05202	5.21	2	IL6, PPARG
Rap1 signaling pathway	hsa04015	4.97	2	AKT2, INSR
Ras signaling pathway	hsa04014	4.9	2	AKT2, INSR
Acute myeloid leukemia	hsa05221	6.74	2	AKT2, TCF7L2
MAPK signaling pathway	hsa04010	4.63	2	AKT2, MAPK8IP1
TNF signaling pathway	hsa04668	5.96	2	IL6, AKT2
Jak-STAT signaling pathway	hsa04630	5.44	2	IL6, AKT2
mTOR signaling pathway	hsa04150	6.72	2	AKT2, IRS1
Carbohydrate digestion and absorption	hsa04973	7.28	2	AKT2, SLC2A2
Tuberculosis	hsa05152	5.17	2	IL6, AKT2
Neuroactive ligand-receptor interaction	hsa04080	4.58	2	MTNR1B, GCGR

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Human Diseases	NEW	1.54	0.011	PTPN1, PPP1R3A, KCNJ11, PDX1, HNF1A, ABCC8, INSR, RETN, SLC2A2, GCGR, AKT2, GPD2, MAPK8IP1, HNF1B, PAX4, NEUROD1, GCK, SLC2A4, TCF7L2, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A
Cancers: Overview	NEW	2.72	0.028	AKT2, SLC2A4, NEUROD1, INSR, GCK, GPD2, PTPN1, IRS2, MAPK8IP1, TCF7L2, IRS1, IL6, HMGA1, SLC2A2, HNF1A, GCGR, PPARG, HNF4A
Endocrine and metabolic diseases	NEW	4.75	0.0	AKT2, SLC2A4, NEUROD1, IRS2, GCK, PDX1, MAPK8IP1, KCNJ11, IRS1, IL6, INSR, SLC2A2, ABCC8, PAX4, HNF1B, HNF1A, PPARG, HNF4A
Maturity onset diabetes of the young (hsa04950)	-	8.07	0.0	PAX4, NEUROD1, GCK, PDX1, SLC2A2, HNF1A, HNF1B, HNF4A
Digestive system	NEW	4.12	0.006	AKT2, HNF1A, INSR, PTPN1, PDX1, RETN, IL6, IRS1, SLC2A2, HNF1B, PPARG, HNF4A
cGMP-PKG signaling pathway (hsa04022)	-	5.32	0.0	AKT2, PPP1R3A, ABCC8, INSR, PPARG, TCF7L2, IRS1, IL6, IRS2, HNF1B, KCNJ11
AMPK signaling pathway (hsa04152)	-	5.8	0.0	SLC2A4, INSR, GCK, AKT2, IRS1, IRS2, PPARG, HNF4A
Insulin secretion (hsa04911)	-	6.18	0.0	PDX1, GCK, ABCC8, TCF7L2, KCNJ11, SLC2A2, HNF1B
cAMP signaling pathway (hsa04024)	NEW	5.05	0.017	PPP1R3A, MAPK8IP1, INSR, AKT2, IL6, IRS2, HNF1B, PPARG
Insulin signaling pathway (hsa04910)	-	5.55	0.0	AKT2, GCK, SLC2A4, PTPN1, MAPK8IP1, PPP1R3A, IRS1, INSR, IRS2
Neurotrophin signaling pathway (hsa04722)	-	5.78	0.024	AKT2, INSR, PTPN1, IRS1, IRS2, PPARG
Endocrine system	NEW	3.26	0.0	PPP1R3A, PTPN1, KCNJ11, PDX1, GCK, RETN, SLC2A2, GCGR, AKT2, ABCC8, MAPK8IP1, HNF1B, NEUROD1, INSR, SLC2A4, TCF7L2, IRS1, IL6, HMGA1, IRS2, PPARG, HNF4A
FoxO signaling pathway (hsa04068)	-	5.63	0.002	SLC2A4, MAPK8IP1, INSR, AKT2, IRS1, IL6, IRS2, PPARG
Prolactin signaling pathway (hsa04917)	-	6.6	0.001	AKT2, GCK, INSR, IRS1, IL6, SLC2A2
PI3K-Akt signaling pathway (hsa04151)	-	4.21	0.042	AKT2, INSR, PTPN1, IRS1, IL6, HMGA1, RETN, IRS2, GCGR, PPARG
Adipocytokine signaling pathway (hsa04920)	-	6.6	0.023	SLC2A4, MAPK8IP1, AKT2, IRS1, IL6, RETN, IRS2, PPARG
Type II diabetes mellitus (hsa04930)	-	7.12	0.0	SLC2A4, ABCC8, SLC2A2, GCK, MAPK8IP1, PDX1, IRS1, KCNJ11, INSR, IRS2
Non-alcoholic fatty liver disease (NAFLD) (hsa04932)	-	5.51	0.0	SLC2A4, MAPK8IP1, INSR, AKT2, IRS1, IL6, IRS2, PPARG
Starch and sucrose metabolism (hsa00500)	-	6.91	0.029	ENPP1, PPARG, INSR, GCK

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Developmental Biology	R-HSA-1266738	3.48	13	AKT2, PAX4, NEUROD1, IRS2, GCK, PDX1, SLC2A4, IRS1, SLC2A2, HNF1A, HNF1B, PPARG, HNF4A
Metabolism	R-HSA-1430728	2.34	9	GPD2, SLC2A4, ABCC8, GCK, ENPP1, KCNJ11, SLC2A2, GCGR, PPARG
Regulation of beta-cell development	R-HSA-186712	7.98	9	PAX4, NEUROD1, GCK, PDX1, AKT2, SLC2A2, HNF1A, HNF1B, HNF4A
Signal Transduction	R-HSA-162582	1.78	9	AKT2, PTPN1, INSR, TCF7L2, IRS1, IL6, IRS2, MTNR1B, GCGR
Regulation of gene expression in beta cells	R-HSA-210745	8.66	7	AKT2, HNF1A, GCK, PDX1, SLC2A2, NEUROD1, HNF4A
Transmembrane transport of small molecules	R-HSA-382551	3.79	6	SLC30A8, SLC2A4, GCK, ABCC8, KCNJ11, SLC2A2
Immune System	R-HSA-168256	2.37	5	AKT2, IRS2, IL6, PTPN1, IRS1
Signaling by GPCR	R-HSA-372790	2.68	5	AKT2, IRS2, MTNR1B, GCGR, IRS1
Disease	R-HSA-1643685	3.33	5	AKT2, TCF7L2, HMGA1, IRS1, IRS2
Diseases of signal transduction	R-HSA-5663202	4.89	4	IRS1, AKT2, TCF7L2, IRS2
Gene Expression	R-HSA-74160	2.72	4	IGF2BP2, AKT2, PPARG, HNF4A
Integration of energy metabolism	R-HSA-163685	6.24	4	GCGR, KCNJ11, ABCC8, SLC2A2
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	4	IRS2, IL6, PTPN1, IRS1
SLC-mediated transmembrane transport	R-HSA-425407	4.95	4	SLC30A8, SLC2A4, SLC2A2, GCK
Signaling by Insulin receptor	R-HSA-74752	4.73	4	AKT2, INSR, IRS1, IRS2
Insulin receptor signalling cascade	R-HSA-74751	4.85	4	IRS2, AKT2, IRS1, INSR
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	3	AKT2, IRS2, IRS1
PI3K/AKT activation	R-HSA-198203	6.32	3	AKT2, IRS2, IRS1
Signaling by Interleukins	R-HSA-449147	4.71	3	IL6, IRS2, IRS1
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	3	AKT2, IRS2, IRS1
Hexose transport	R-HSA-189200	7.43	3	SLC2A4, SLC2A2, GCK
IGF1R signaling cascade	R-HSA-2428924	4.85	3	AKT2, IRS2, IRS1
Downstream signal transduction	R-HSA-186763	4.65	3	AKT2, IRS2, IRS1
GAB1 signalosome	R-HSA-180292	6.31	3	AKT2, IRS2, IRS1
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	3	AKT2, IRS2, IRS1
Signaling by ERBB4	R-HSA-1236394	4.7	3	AKT2, IRS2, IRS1
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	3	IL6, IRS2, IRS1
Adaptive Immune System	R-HSA-1280218	3.19	3	AKT2, IRS2, IRS1
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95	3	AKT2, IRS2, IRS1
IRS activation	R-HSA-74713	10.66	3	IRS2, IRS1, INSR
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	3	AKT2, IRS2, IRS1
Metabolism of carbohydrates	R-HSA-71387	4.93	3	SLC2A4, SLC2A2, GCK
PIP3 activates AKT signaling	R-HSA-1257604	6.37	3	AKT2, IRS2, IRS1
PI3K Cascade	R-HSA-109704	6.68	3	AKT2, IRS2, IRS1
Generic Transcription Pathway	R-HSA-212436	3.86	3	AKT2, PPARG, HNF4A
PI-3K cascade:FGFR1	R-HSA-5654689	6.37	3	AKT2, IRS2, IRS1
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	3	GCGR, IRS2, IRS1
IRS-mediated signalling	R-HSA-112399	4.87	3	AKT2, IRS2, IRS1
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	3	AKT2, IRS2, IRS1
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	3	AKT2, IRS2, IRS1
Signaling by FGFR4	R-HSA-5654743	4.69	3	AKT2, IRS2, IRS1
Signaling by FGFR3	R-HSA-5654741	4.69	3	AKT2, IRS2, IRS1
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	3	AKT2, IRS2, IRS1
Signaling by FGFR	R-HSA-190236	4.67	3	AKT2, IRS2, IRS1
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56	3	AKT2, IRS2, IRS1
Signaling by VEGF	R-HSA-194138	4.66	3	AKT2, IRS2, IRS1
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	3	AKT2, IRS2, IRS1
GPCR downstream signaling	R-HSA-388396	3.07	3	AKT2, MTNR1B, GCGR
Innate Immune System	R-HSA-168249	3.17	3	AKT2, IRS2, IRS1
Signaling by SCF-KIT	R-HSA-1433557	4.73	3	AKT2, IRS2, IRS1
Metabolism of proteins	R-HSA-392499	3.41	3	SLC30A8, WFS1, TCF7L2
PI-3K cascade:FGFR4	R-HSA-5654720	6.37	3	AKT2, IRS2, IRS1
Signal attenuation	R-HSA-74749	9.66	3	IRS2, IRS1, INSR
Signaling by PDGF	R-HSA-186797	4.53	3	AKT2, IRS2, IRS1
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37	3	AKT2, IRS2, IRS1
PI-3K cascade:FGFR2	R-HSA-5654695	6.37	3	AKT2, IRS2, IRS1
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	3	AKT2, IRS2, IRS1
Glucose transport	R-HSA-70153	7.62	3	SLC2A4, SLC2A2, GCK
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds	R-HSA-425366	6.34	3	SLC30A8, SLC2A4, SLC2A2
Signaling by EGFR	R-HSA-177929	4.59	3	AKT2, IRS2, IRS1
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	3	AKT2, IRS2, IRS1
MAPK family signaling cascades	R-HSA-5683057	4.89	3	IL6, IRS2, IRS1
Regulation of insulin secretion	R-HSA-422356	6.66	3	KCNJ11, SLC2A2, ABCC8
Signalling by NGF	R-HSA-166520	4.23	3	AKT2, IRS2, IRS1
Signaling by FGFR2	R-HSA-5654738	4.68	3	AKT2, IRS2, IRS1
Signaling by FGFR1	R-HSA-5654736	4.69	3	AKT2, IRS2, IRS1
Growth hormone receptor signaling	R-HSA-982772	8.4	3	PTPN1, IRS2, IRS1
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37	3	AKT2, IRS2, IRS1
PI-3K cascade:FGFR3	R-HSA-5654710	6.37	3	AKT2, IRS2, IRS1
DAP12 interactions	R-HSA-2172127	4.56	3	AKT2, IRS2, IRS1
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	3	AKT2, IRS2, IRS1
Signaling by ERBB2	R-HSA-1227986	4.66	3	AKT2, IRS2, IRS1
DAP12 signaling	R-HSA-2424491	4.64	3	AKT2, IRS2, IRS1
Inwardly rectifying K+ channels	R-HSA-1296065	8.03	2	KCNJ11, ABCC8
Regulation of gene expression in early pancreatic precursor cells	R-HSA-210747	9.98	2	HNF1B, PDX1
Cellular Senescence	R-HSA-2559583	5.7	2	IL6, HMGA1
ABC-family proteins mediated transport	R-HSA-382556	7.59	2	KCNJ11, ABCC8
Transcriptional regulation of white adipocyte differentiation	R-HSA-381340	6.7	2	SLC2A4, PPARG
Interleukin-2 signaling	R-HSA-451927	5.05	2	IRS2, IRS1
Frs2-mediated activation	R-HSA-170968	5.12	2	IRS2, IRS1
Peptide hormone metabolism	R-HSA-2980736	6.61	2	SLC30A8, TCF7L2
deactivation of the beta-catenin transactivating complex	R-HSA-3769402	7.59	2	AKT2, TCF7L2
Fatty acid, triacylglycerol, and ketone body metabolism	R-HSA-535734	5.44	2	PPARG, GPD2
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	2	IRS2, IRS1
RAF/MAP kinase cascade	R-HSA-5673001	5.15	2	IRS2, IRS1
Nuclear Receptor transcription pathway	R-HSA-383280	7.31	2	PPARG, HNF4A
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	2	IRS2, IRS1
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	2	AKT2, PTPN1
FCERI mediated MAPK activation	R-HSA-2871796	4.32	2	IRS2, IRS1
Cellular responses to stress	R-HSA-2262752	4.56	2	IL6, HMGA1
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells	R-HSA-210746	10.66	2	PAX4, NEUROD1
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	2	IRS2, IRS1
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	2	IRS2, IRS1
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	2	IRS2, IRS1
Neuronal System	R-HSA-112316	4.82	2	KCNJ11, ABCC8
GPCR ligand binding	R-HSA-500792	4.19	2	MTNR1B, GCGR
Signalling to ERKs	R-HSA-187687	5.04	2	IRS2, IRS1
Facilitative Na+-independent glucose transporters	R-HSA-428790	9.28	2	SLC2A4, SLC2A2
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	2	IRS2, IRS1
Potassium Channels	R-HSA-1296071	6.35	2	KCNJ11, ABCC8
Signaling by Leptin	R-HSA-2586552	5.1	2	IRS2, IRS1
Interleukin receptor SHC signaling	R-HSA-912526	5.09	2	IRS2, IRS1
Constitutive Signaling by Aberrant PI3K in Cancer	R-HSA-2219530	7.05	2	IRS2, IRS1
Membrane Trafficking	R-HSA-199991	5.26	2	AKT2, SLC2A4
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	2	PPARG, GPD2
Signalling to RAS	R-HSA-167044	5.08	2	IRS2, IRS1
Translocation of GLUT4 to the plasma membrane	R-HSA-1445148	6.77	2	AKT2, SLC2A4
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	2	IRS2, IRS1
SHC1 events in EGFR signaling	R-HSA-180336	5.15	2	IRS2, IRS1
Vesicle-mediated transport	R-HSA-5653656	4.33	2	AKT2, SLC2A4
Prolonged ERK activation events	R-HSA-169893	5.11	2	IRS2, IRS1
Signaling by Wnt	R-HSA-195721	4.79	2	AKT2, TCF7L2
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	IRS2, IRS1
GRB2 events in EGFR signaling	R-HSA-179812	5.15	2	IRS2, IRS1
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	2	IRS2, IRS1
ARMS-mediated activation	R-HSA-170984	5.12	2	IRS2, IRS1
SOS-mediated signalling	R-HSA-112412	5.15	2	IRS2, IRS1
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	2	IRS2, IRS1
TCF dependent signaling in response to WNT	R-HSA-201681	5.36	2	AKT2, TCF7L2
Axon guidance	R-HSA-422475	3.93	2	IRS2, IRS1
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	2	IRS2, IRS1
ATP sensitive Potassium channels	R-HSA-1296025	10.98	2	KCNJ11, ABCC8
Hemostasis	R-HSA-109582	3.98	2	AKT2, PTPN1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells (R-HSA-210746)	-	10.66	0.022	PAX4, NEUROD1
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192)	-	4.85	0.015	AKT2, SLC2A4, MAPK8IP1, INSR, PTPN1, IRS1, IL6, IRS2, PPARG
Regulation of gene expression in beta cells (R-HSA-210745)	-	8.66	0.0	AKT2, HNF1A, GCK, PDX1, SLC2A2, NEUROD1, HNF4A
Regulation of beta-cell development (R-HSA-186712)	-	7.98	0.0	PAX4, NEUROD1, GCK, PDX1, AKT2, TCF7L2, SLC2A2, HNF1A, HNF1B, HNF4A
Growth hormone receptor signaling (R-HSA-982772)	-	8.4	0.013	PTPN1, IRS2, IRS1
ATP sensitive Potassium channels (R-HSA-1296025)	-	10.98	0.014	KCNJ11, ABCC8
Hexose transport (R-HSA-189200)	-	7.43	0.008	SLC2A4, INSR, GCK, SLC2A2
IRS activation (R-HSA-74713)	-	10.66	0.0	IRS2, IRS1, INSR
Integration of energy metabolism (R-HSA-163685)	-	6.24	0.016	SLC2A4, ABCC8, TCF7L2, KCNJ11, SLC2A2, GCGR
Transmembrane transport of small molecules (R-HSA-382551)	-	3.79	0.0	SLC30A8, SLC2A4, HNF1A, SLC2A2, GCK, PTPN1, KCNJ11, IRS1, IL6, INSR, IRS2, ABCC8, HNF1B, PPARG, GCGR
IRS-mediated signalling (R-HSA-112399)	-	4.87	0.013	SLC2A4, MAPK8IP1, INSR, PTPN1, AKT2, IRS1, IL6, IRS2, PPARG
Signal attenuation (R-HSA-74749)	-	9.66	0.001	IRS2, IRS1, INSR
SLC-mediated transmembrane transport (R-HSA-425407)	-	4.95	0.027	SLC30A8, SLC2A4, HNF1A, GCK, INSR, IRS1, SLC2A2, PPARG
IGF1R signaling cascade (R-HSA-2428924)	-	4.85	0.015	SLC2A4, MAPK8IP1, INSR, PTPN1, AKT2, IRS1, IL6, IRS2, PPARG
Peptide hormone metabolism (R-HSA-2980736)	-	6.61	0.002	SLC30A8, AKT2, HNF1A, INSR, TCF7L2, RETN, IL6
IRS-related events triggered by IGF1R (R-HSA-2428928)	-	4.85	0.015	SLC2A4, MAPK8IP1, INSR, PTPN1, AKT2, IRS1, IL6, IRS2, PPARG
PI3K Cascade (R-HSA-109704)	-	6.68	0.02	IRS1, IL6, IRS2, AKT2, INSR
Signaling by Insulin receptor (R-HSA-74752)	-	4.73	0.029	SLC2A4, MAPK8IP1, INSR, PTPN1, AKT2, IRS1, IL6, IRS2, PPARG
Developmental Biology (R-HSA-1266738)	-	3.48	0.0	AKT2, PAX4, NEUROD1, INSR, GCK, SLC2A2, PTPN1, PDX1, MAPK8IP1, SLC2A4, IRS1, IL6, KCNJ11, GCGR, HMGA1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A
Insulin receptor signalling cascade (R-HSA-74751)	-	4.85	0.015	SLC2A4, MAPK8IP1, INSR, PTPN1, AKT2, IRS1, IL6, IRS2, PPARG

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	32	PTPN1, ENPP1, PAX4, KCNJ11, CAPN10, MTNR1B, PDX1, HNF1A, ABCC8, INSR, RETN, WFS1, SLC2A2, GCGR, IGF2BP2, AKT2, GPD2, CDKAL1, MAPK8IP1, HNF1B, SLC30A8, NEUROD1, GCK, SLC2A4, TCF7L2, IRS1, IL6, HMGA1, HNF4A, IRS2, PPARG, LIPC
protein binding (GO:0005515)	0.46	30	PTPN1, ENPP1, AKT2, TCF7L2, CAPN10, MTNR1B, PDX1, HNF1A, GCK, RETN, WFS1, SLC2A2, IGF2BP2, PAX4, ABCC8, CDKAL1, MAPK8IP1, HNF1B, SLC30A8, NEUROD1, INSR, SLC2A4, KCNJ11, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A
organic cyclic compound binding (GO:0097159)	1.05	17	AKT2, PAX4, NEUROD1, INSR, GCK, IGF2BP2, PTPN1, PDX1, ENPP1, TCF7L2, KCNJ11, HMGA1, ABCC8, HNF1A, HNF1B, PPARG, HNF4A
heterocyclic compound binding (GO:1901363)	1.06	17	AKT2, PAX4, NEUROD1, INSR, GCK, IGF2BP2, PTPN1, PDX1, ENPP1, TCF7L2, KCNJ11, HMGA1, ABCC8, HNF1A, HNF1B, PPARG, HNF4A
catalytic activity (GO:0003824)	1.05	15	GPD2, AKT2, ABCC8, INSR, GCK, ENPP1, PTPN1, IRS1, CAPN10, HMGA1, LIPC, IRS2, CDKAL1, MAPK8IP1, HNF4A
receptor binding (GO:0005102)	2.43	12	PTPN1, IRS2, INSR, ENPP1, IL6, IRS1, TCF7L2, HMGA1, RETN, SLC2A2, PPARG, HNF4A
macromolecular complex binding (GO:0044877)	2.61	12	PDX1, NEUROD1, SLC2A2, INSR, ENPP1, PTPN1, IRS1, HMGA1, IRS2, HNF1B, PPARG, LIPC
nucleic acid binding (GO:0003676)	1.44	12	PAX4, NEUROD1, IGF2BP2, PTPN1, ENPP1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
enzyme binding (GO:0019899)	2.27	11	WFS1, INSR, GCK, PTPN1, MAPK8IP1, AKT2, IRS1, TCF7L2, HMGA1, IRS2, PPARG
ion binding (GO:0043167)	1.36	10	SLC30A8, PTPN1, GCK, INSR, GPD2, ENPP1, CDKAL1, KCNJ11, PPARG, HNF4A
sequence-specific DNA binding (GO:0043565)	2.79	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
cation binding (GO:0043169)	1.4	9	SLC30A8, PTPN1, GPD2, GCK, ENPP1, CDKAL1, KCNJ11, PPARG, HNF4A
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
nucleic acid binding transcription factor activity (GO:0001071)	2.65	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
DNA binding (GO:0003677)	1.92	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
metal ion binding (GO:0046872)	1.41	9	SLC30A8, PTPN1, GPD2, GCK, ENPP1, CDKAL1, KCNJ11, PPARG, HNF4A
transcription regulatory region DNA binding (GO:0044212)	3.03	8	PAX4, NEUROD1, PDX1, TCF7L2, HNF1A, HNF1B, PPARG, HNF4A
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	8	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, PPARG, HNF4A
transcription factor binding (GO:0008134)	3.46	8	PDX1, HNF1A, WFS1, TCF7L2, HMGA1, NEUROD1, PPARG, HNF4A
regulatory region nucleic acid binding (GO:0001067)	3.03	8	PAX4, NEUROD1, PDX1, TCF7L2, HNF1A, HNF1B, PPARG, HNF4A
molecular transducer activity (GO:0060089)	2.32	8	ABCC8, INSR, ENPP1, KCNJ11, MTNR1B, PPARG, GCGR, HNF4A
transferase activity (GO:0016740)	1.95	8	AKT2, GCK, INSR, MAPK8IP1, CDKAL1, IRS1, IRS2, LIPC
receptor activity (GO:0004872)	2.32	8	ABCC8, INSR, ENPP1, KCNJ11, MTNR1B, PPARG, GCGR, HNF4A
signal transducer activity (GO:0004871)	2.28	8	ABCC8, INSR, IRS1, IRS2, MTNR1B, PPARG, GCGR, HNF4A
regulatory region DNA binding (GO:0000975)	3.03	8	PAX4, NEUROD1, PDX1, TCF7L2, HNF1A, HNF1B, PPARG, HNF4A
protein complex binding (GO:0032403)	3.09	8	PDX1, SLC2A2, INSR, ENPP1, PTPN1, IRS1, IRS2, HNF1B
double-stranded DNA binding (GO:0003690)	3.09	8	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, PPARG, HNF4A
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	8	PAX4, NEUROD1, PDX1, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
hydrolase activity (GO:0016787)	1.9	7	PTPN1, ABCC8, ENPP1, CAPN10, HMGA1, LIPC, HNF4A
carbohydrate derivative binding (GO:0097367)	2.03	7	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11, LIPC
small molecule binding (GO:0036094)	1.89	7	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11, IGF2BP2
nucleotide binding (GO:0000166)	1.96	7	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11, IGF2BP2
protein kinase binding (GO:0019901)	3.44	7	AKT2, MAPK8IP1, INSR, PTPN1, IRS1, TCF7L2, IRS2
kinase binding (GO:0019900)	3.32	7	AKT2, MAPK8IP1, INSR, PTPN1, IRS1, TCF7L2, IRS2
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	7	PAX4, HNF1A, PDX1, TCF7L2, NEUROD1, PPARG, HNF4A
identical protein binding (GO:0042802)	2.63	7	SLC30A8, HNF1A, ENPP1, MAPK8IP1, HNF1B, PPARG, HNF4A
protein dimerization activity (GO:0046983)	2.72	7	SLC30A8, PDX1, HNF1A, ENPP1, NEUROD1, HNF1B, HNF4A
nucleoside phosphate binding (GO:1901265)	1.96	7	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11, IGF2BP2
signaling receptor activity (GO:0038023)	2.49	6	ABCC8, INSR, MTNR1B, PPARG, GCGR, HNF4A
adenyl nucleotide binding (GO:0030554)	2.4	6	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	6	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	6	AKT2, MAPK8IP1, INSR, GCK, IRS1, IRS2
kinase activity (GO:0016301)	2.93	6	AKT2, MAPK8IP1, INSR, GCK, IRS1, IRS2
RNA polymerase II regulatory region DNA binding (GO:0001012)	3.36	6	PDX1, HNF1A, PAX4, TCF7L2, NEUROD1, HNF4A
ATP binding (GO:0005524)	2.43	6	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11
ribonucleotide binding (GO:0032553)	2.19	6	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11
purine ribonucleoside binding (GO:0032550)	2.22	6	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11
adenyl ribonucleotide binding (GO:0032559)	2.41	6	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	3.37	6	PDX1, HNF1A, PAX4, TCF7L2, NEUROD1, HNF4A
ribonucleoside binding (GO:0032549)	2.22	6	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11
purine ribonucleotide binding (GO:0032555)	2.2	6	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11
purine nucleotide binding (GO:0017076)	2.19	6	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11
transmembrane receptor activity (GO:0099600)	2.53	6	INSR, ABCC8, KCNJ11, GCGR, PPARG, MTNR1B
purine nucleoside binding (GO:0001883)	2.22	6	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11
nucleoside binding (GO:0001882)	2.21	6	AKT2, ABCC8, GCK, INSR, ENPP1, KCNJ11
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	5	SLC30A8, KCNJ11, SLC2A4, ABCC8, SLC2A2
substrate-specific transporter activity (GO:0022892)	2.72	5	SLC30A8, KCNJ11, SLC2A4, ABCC8, SLC2A2
protein phosphatase binding (GO:0019903)	4.93	5	IRS2, PTPN1, PPARG, GCK, INSR
transition metal ion binding (GO:0046914)	2.48	5	SLC30A8, ENPP1, PTPN1, PPARG, HNF4A
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	5	IRS1, AKT2, INSR, IRS2, GCK
transporter activity (GO:0005215)	2.57	5	SLC30A8, KCNJ11, SLC2A4, ABCC8, SLC2A2
insulin receptor binding (GO:0005158)	6.27	5	IRS2, PTPN1, ENPP1, IRS1, SLC2A2
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0003705)	5.23	5	HMGA1, HNF1B, PAX4, PDX1, HNF4A
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	5	HMGA1, PTPN1, ENPP1, HNF4A, LIPC
transmembrane signaling receptor activity (GO:0004888)	2.57	5	MTNR1B, GCGR, PPARG, ABCC8, INSR
transmembrane transporter activity (GO:0022857)	2.82	5	SLC30A8, KCNJ11, SLC2A4, ABCC8, SLC2A2
phosphatase binding (GO:0019902)	4.63	5	IRS2, PTPN1, PPARG, GCK, INSR
zinc ion binding (GO:0008270)	2.66	5	SLC30A8, ENPP1, PTPN1, PPARG, HNF4A
protein homodimerization activity (GO:0042803)	3.16	5	SLC30A8, ENPP1, HNF1B, HNF1A, HNF4A
protein heterodimerization activity (GO:0046982)	3.64	4	NEUROD1, HNF1B, HNF1A, PDX1
activating transcription factor binding (GO:0033613)	5.68	4	NEUROD1, WFS1, PPARG, HNF4A
cytoskeletal protein binding (GO:0008092)	3.02	4	KCNJ11, PPARG, CAPN10, MAPK8IP1
chromatin binding (GO:0003682)	3.64	4	HMGA1, NEUROD1, PPARG, PDX1
lipid binding (GO:0008289)	3.26	4	LIPC, PPARG, HNF4A, INSR
core promoter proximal region DNA binding (GO:0001159)	3.82	4	HNF1B, NEUROD1, PDX1, TCF7L2
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	3.98	4	HNF1A, NEUROD1, HMGA1, HNF4A
protein domain specific binding (GO:0019904)	3.32	4	IRS1, TCF7L2, IRS2, INSR
core promoter binding (GO:0001047)	4.71	4	PPARG, PDX1, HNF1A, HNF4A
core promoter sequence-specific DNA binding (GO:0001046)	5.12	4	PPARG, PDX1, HNF1A, HNF4A
molecular function regulator (GO:0098772)	2.51	4	GCGR, MAPK8IP1, IRS2, IRS1
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	3	GCGR, IRS2, IRS1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077)	4.31	3	HNF1A, NEUROD1, HNF4A
sulfur compound binding (GO:1901681)	4.32	3	ENPP1, HNF4A, LIPC
G-protein coupled receptor activity (GO:0004930)	2.95	3	MTNR1B, PPARG, GCGR
phosphatidylinositol 3-kinase binding (GO:0043548)	6.41	3	IRS2, IRS1, INSR
transcription coactivator activity (GO:0003713)	4.04	3	NEUROD1, PPARG, HMGA1
transcription cofactor activity (GO:0003712)	3.44	3	NEUROD1, PPARG, HMGA1
transcription factor activity, transcription factor binding (GO:0000989)	3.36	3	NEUROD1, PPARG, HMGA1
transcription factor activity, protein binding (GO:0000988)	3.35	3	NEUROD1, PPARG, HMGA1
fatty acid binding (GO:0005504)	6.37	3	PPARG, HNF4A, INSR
metal ion transmembrane transporter activity (GO:0046873)	3.71	3	SLC30A8, KCNJ11, ABCC8
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982)	3.94	3	HNF1A, NEUROD1, HNF4A
anion binding (GO:0043168)	4.17	3	PPARG, HNF4A, INSR
cation transmembrane transporter activity (GO:0008324)	3.32	3	SLC30A8, KCNJ11, ABCC8
nuclear hormone receptor binding (GO:0035257)	4.7	3	HMGA1, TCF7L2, PPARG
core promoter proximal region sequence-specific DNA binding (GO:0000987)	3.83	3	PDX1, NEUROD1, TCF7L2
hormone receptor binding (GO:0051427)	4.57	3	HMGA1, TCF7L2, PPARG
monocarboxylic acid binding (GO:0033293)	5.61	3	PPARG, HNF4A, INSR
RNA polymerase II transcription factor binding (GO:0001085)	5.08	3	TCF7L2, NEUROD1, HNF4A
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	3	SLC30A8, KCNJ11, ABCC8
carboxylic acid binding (GO:0031406)	4.64	3	PPARG, HNF4A, INSR
ion transmembrane transporter activity (GO:0015075)	3.04	3	SLC30A8, KCNJ11, ABCC8
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	3.88	3	PDX1, NEUROD1, TCF7L2
peptide hormone binding (GO:0017046)	6.13	2	GCGR, INSR
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	4.31	2	IRS2, IRS1
potassium channel activity (GO:0005267)	4.94	2	KCNJ11, ABCC8
cation channel activity (GO:0005261)	4.04	2	KCNJ11, ABCC8
protein kinase C binding (GO:0005080)	5.83	2	AKT2, IRS1
D-glucose transmembrane transporter activity (GO:0055056)	7.66	2	SLC2A4, SLC2A2
phosphoric ester hydrolase activity (GO:0042578)	3.82	2	PTPN1, ENPP1
transcription factor activity, direct ligand regulated sequence-specific DNA binding (GO:0098531)	5.87	2	PPARG, HNF4A
phosphatidylinositol 3-kinase activity (GO:0035004)	5.49	2	IRS2, IRS1
ion channel binding (GO:0044325)	5.02	2	KCNJ11, ABCC8
substrate-specific channel activity (GO:0022838)	3.67	2	KCNJ11, ABCC8
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding (GO:0004879)	5.87	2	PPARG, HNF4A
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934)	5.61	2	IRS2, IRS1
coenzyme binding (GO:0050662)	4.53	2	HNF4A, INSR
peptide binding (GO:0042277)	4.22	2	GCGR, INSR
signaling adaptor activity (GO:0035591)	5.43	2	IRS1, MAPK8IP1
carbohydrate transporter activity (GO:1901476)	5.95	2	SLC2A4, SLC2A2
ATP-activated inward rectifier potassium channel activity (GO:0015272)	8.13	2	KCNJ11, ABCC8
SNARE binding (GO:0000149)	4.87	2	CAPN10, ABCC8
receptor tyrosine kinase binding (GO:0030971)	5.77	2	PTPN1, IRS1
ligand-gated ion channel activity (GO:0015276)	4.8	2	KCNJ11, ABCC8
hexose transmembrane transporter activity (GO:0015149)	6.79	2	SLC2A4, SLC2A2
phosphatidylinositol bisphosphate kinase activity (GO:0052813)	5.56	2	IRS2, IRS1
calcium ion binding (GO:0005509)	3.17	2	ENPP1, GPD2
protein kinase activity (GO:0004672)	3.27	2	AKT2, INSR
passive transmembrane transporter activity (GO:0022803)	3.6	2	KCNJ11, ABCC8
1-phosphatidylinositol-3-kinase activity (GO:0016303)	5.98	2	IRS2, IRS1
monosaccharide transmembrane transporter activity (GO:0015145)	6.79	2	SLC2A4, SLC2A2
insulin-like growth factor receptor binding (GO:0005159)	7.03	2	IRS1, INSR
RNA binding (GO:0003723)	2.36	2	PTPN1, IGF2BP2
glucose transmembrane transporter activity (GO:0005355)	6.85	2	SLC2A4, SLC2A2
phosphatidylinositol kinase activity (GO:0052742)	5.81	2	IRS2, IRS1
sugar transmembrane transporter activity (GO:0051119)	6.3	2	SLC2A4, SLC2A2
amide binding (GO:0033218)	4.14	2	GCGR, INSR
ion channel activity (GO:0005216)	3.71	2	KCNJ11, ABCC8
poly(A) RNA binding (GO:0044822)	2.69	2	PTPN1, IGF2BP2
carbohydrate binding (GO:0030246)	4.17	2	ENPP1, GCK
retinoid X receptor binding (GO:0046965)	6.79	2	HMGA1, PPARG
cofactor binding (GO:0048037)	4.16	2	HNF4A, INSR
RNA polymerase II activating transcription factor binding (GO:0001102)	6.13	2	NEUROD1, HNF4A
ligand-dependent nuclear receptor transcription coactivator activity (GO:0030374)	5.77	2	HMGA1, PPARG
hormone binding (GO:0042562)	5.53	2	GCGR, INSR
binding, bridging (GO:0060090)	4.57	2	MAPK8IP1, IRS1
carbohydrate transmembrane transporter activity (GO:0015144)	5.95	2	SLC2A4, SLC2A2
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	2	ENPP1, ABCC8
RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979)	5.77	2	HNF1A, HNF4A
pyrophosphatase activity (GO:0016462)	3.04	2	ENPP1, ABCC8
nuclease activity (GO:0004518)	4.33	2	ENPP1, HMGA1
protein tyrosine kinase binding (GO:1990782)	5.7	2	PTPN1, IRS1
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	2	ENPP1, ABCC8
steroid hormone receptor activity (GO:0003707)	5.66	2	PPARG, HNF4A
voltage-gated channel activity (GO:0022832)	4.49	2	KCNJ11, ABCC8
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3.87	2	KCNJ11, ABCC8
channel activity (GO:0015267)	3.6	2	KCNJ11, ABCC8
gated channel activity (GO:0022836)	3.96	2	KCNJ11, ABCC8
voltage-gated potassium channel activity (GO:0005249)	5.24	2	KCNJ11, ABCC8
ligand-gated channel activity (GO:0022834)	4.8	2	KCNJ11, ABCC8
retinoic acid receptor binding (GO:0042974)	5.83	2	HMGA1, PPARG
voltage-gated cation channel activity (GO:0022843)	4.83	2	KCNJ11, ABCC8
voltage-gated ion channel activity (GO:0005244)	4.49	2	KCNJ11, ABCC8
potassium ion transmembrane transporter activity (GO:0015079)	4.77	2	KCNJ11, ABCC8
inward rectifier potassium channel activity (GO:0005242)	6.65	2	KCNJ11, ABCC8

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
signaling receptor activity (GO:0038023)	-	2.49	0.001	SLC2A4, NEUROD1, ABCC8, INSR, PTPN1, PDX1, IL6, RETN, TCF7L2, HMGA1, LIPC, IRS2, IRS1, GCGR, PPARG, MTNR1B, HNF4A
activating transcription factor binding (GO:0033613)	-	5.68	0.001	NEUROD1, WFS1, PPARG, HNF4A
RNA polymerase II regulatory region DNA binding (GO:0001012)	-	3.36	0.001	AKT2, PAX4, NEUROD1, PDX1, IL6, IRS1, TCF7L2, HMGA1, PPARG, HNF4A
D-glucose transmembrane transporter activity (GO:0055056)	-	7.66	0.003	SLC2A4, SLC2A2
enzyme binding (GO:0019899)	-	2.27	0.0	AKT2, PPP1R3A, CDKAL1, NEUROD1, INSR, GCK, PTPN1, PDX1, MAPK8IP1, WFS1, IRS1, IL6, GCGR, HMGA1, IRS2, ABCC8, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705)	-	5.23	0.004	PAX4, HNF1A, NEUROD1, HNF1B, PPARG, HNF4A
molecular transducer activity (GO:0060089)	-	2.32	0.001	AKT2, SLC2A4, NEUROD1, ABCC8, INSR, PTPN1, PDX1, MAPK8IP1, IL6, IRS1, TCF7L2, HMGA1, LIPC, IRS2, GCGR, PPARG, MTNR1B, HNF4A, RETN
RNA polymerase II transcription factor binding transcription factor activity (GO:0001076)	NEW	4.84	0.001	NEUROD1, IL6, TCF7L2, HMGA1, HNF1A, PPARG, HNF4A
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077)	-	4.31	0.009	PDX1, HNF1A, TCF7L2, NEUROD1, HNF1B, PPARG, HNF4A
receptor activity (GO:0004872)	-	2.32	0.0	PTPN1, ENPP1, SLC2A4, KCNJ11, MTNR1B, PDX1, HNF1A, INSR, RETN, GCGR, ABCC8, MAPK8IP1, HNF1B, NEUROD1, TCF7L2, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A
signal transducer activity (GO:0004871)	-	2.28	0.001	AKT2, SLC2A4, NEUROD1, ABCC8, INSR, PTPN1, PDX1, MAPK8IP1, TCF7L2, IRS1, IL6, HMGA1, LIPC, IRS2, GCGR, PPARG, MTNR1B, HNF4A, RETN
enzyme inhibitor activity (GO:0004857)	NEW	3.78	0.012	PPP1R3A, MAPK8IP1, INSR, PTPN1, IRS1, IL6, IRS2, GCGR, PPARG, HNF4A
anion binding (GO:0043168)	-	4.17	0.006	PTPN1, ENPP1, SLC2A4, KCNJ11, MTNR1B, PDX1, HNF1A, ABCC8, INSR, GCGR, IGF2BP2, AKT2, GPD2, MAPK8IP1, NEUROD1, GCK, TCF7L2, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A
sequence-specific DNA binding (GO:0043565)	-	2.79	0.01	PAX4, NEUROD1, PDX1, AKT2, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A
structure-specific DNA binding (GO:0043566)	NEW	4.98	0.002	PAX4, NEUROD1, SLC2A2, INSR, TCF7L2, IL6, HMGA1, IRS2, PPARG
arachidonate 15-lipoxygenase activity (GO:0050473)	NEW	8.64	0.016	IL6, PPARG
carbohydrate transporter activity (GO:1901476)	-	5.95	0.036	SLC2A4, HNF1A, SLC2A2
protein dimerization activity (GO:0046983)	-	2.72	0.0	SLC30A8, AKT2, NEUROD1, ABCC8, INSR, SLC2A2, GPD2, PTPN1, PDX1, ENPP1, IL6, IRS1, TCF7L2, HMGA1, MAPK8IP1, HNF1A, HNF1B, PPARG, GCGR, HNF4A
phosphatidylinositol 3-kinase binding (GO:0043548)	-	6.41	0.017	IRS2, IRS1, INSR
transcription coactivator activity (GO:0003713)	-	4.04	0.045	AKT2, NEUROD1, IL6, TCF7L2, HMGA1, HNF1A, PPARG, HNF4A
ATP binding (GO:0005524)	-	2.43	0.02	AKT2, NEUROD1, INSR, GCK, PTPN1, PDX1, ENPP1, SLC2A4, IRS1, IL6, KCNJ11, HMGA1, IRS2, ABCC8, MTNR1B, MAPK8IP1, PPARG, GCGR
protein complex binding (GO:0032403)	-	3.09	0.026	PDX1, NEUROD1, SLC2A2, INSR, ENPP1, PTPN1, IRS1, IL6, IRS2, HNF1A, HNF1B, MAPK8IP1, PPARG, GCGR
double-stranded DNA binding (GO:0003690)	-	3.09	0.001	PAX4, NEUROD1, IL6, TCF7L2, HMGA1, IRS2, PPARG
carbohydrate transmembrane transporter activity (GO:0015144)	-	5.95	0.036	SLC2A4, HNF1A, SLC2A2
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981)	-	3.29	0.002	PAX4, NEUROD1, PDX1, TCF7L2, IRS1, IL6, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
protein homodimerization activity (GO:0042803)	-	3.16	0.0	SLC30A8, PDX1, NEUROD1, GPD2, INSR, PTPN1, ENPP1, TCF7L2, IRS1, AKT2, IL6, HMGA1, MAPK8IP1, HNF1A, HNF1B, PPARG, GCGR, HNF4A
sugar transmembrane transporter activity (GO:0051119)	-	6.3	0.018	SLC2A4, HNF1A, SLC2A2
transporter activity (GO:0005215)	-	2.57	0.039	SLC30A8, SLC2A4, HNF1A, SLC2A2, ABCC8, PTPN1, IL6, IRS1, KCNJ11, WFS1, IRS2, HNF1B, PPARG, GCGR, HNF4A
transcription factor binding (GO:0008134)	-	3.46	0.001	AKT2, NEUROD1, PDX1, IL6, IRS1, WFS1, TCF7L2, HMGA1, MAPK8IP1, HNF1A, PPARG, HNF4A
insulin receptor binding (GO:0005158)	-	6.27	0.0	PTPN1, INSR, ENPP1, IRS1, IRS2
regulatory region nucleic acid binding (GO:0001067)	-	3.03	0.0	PAX4, NEUROD1, PDX1, AKT2, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A
lipid binding (GO:0008289)	-	3.26	0.041	AKT2, HNF1A, MAPK8IP1, INSR, IRS1, IL6, RETN, IRS2, MTNR1B, PPARG, GCGR, HNF4A
hydrolase activity, acting on ester bonds (GO:0016788)	-	3.1	0.014	PTPN1, NEUROD1, INSR, GCK, ENPP1, IRS1, IL6, GCGR, HMGA1, HNF1B, PPARG, MTNR1B, LIPC
core promoter binding (GO:0001047)	-	4.71	0.003	PDX1, NEUROD1, IL6, TCF7L2, PPARG, HNF4A
hormone receptor binding (GO:0051427)	-	4.57	0.003	HNF1A, INSR, IL6, TCF7L2, HMGA1, SLC2A2, PPARG
hormone binding (GO:0042562)	-	5.53	0.006	IRS2, GCGR, PPARG, RETN, INSR
transcription regulatory region DNA binding (GO:0044212)	-	3.03	0.0	PAX4, NEUROD1, PDX1, AKT2, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A
adenyl nucleotide binding (GO:0030554)	-	2.4	0.029	AKT2, SLC2A4, NEUROD1, GCK, INSR, PTPN1, PDX1, ENPP1, IL6, IRS1, KCNJ11, HMGA1, IRS2, ABCC8, GCGR, MAPK8IP1, PPARG, MTNR1B
sequence-specific DNA binding transcription factor activity (GO:0003700)	-	2.65	0.034	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228)	-	3.98	0.007	PDX1, NEUROD1, TCF7L2, IL6, HNF1A, HNF1B, PPARG, HNF4A
transcription regulatory region sequence-specific DNA binding (GO:0000976)	-	3.24	0.0	PAX4, NEUROD1, PDX1, AKT2, IRS1, IL6, HMGA1, IRS2, PPARG, TCF7L2, HNF4A
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	-	3.37	0.001	AKT2, PAX4, NEUROD1, PDX1, IL6, IRS1, TCF7L2, HMGA1, PPARG, HNF4A
protein binding (GO:0005515)	-	0.46	0.005	PTPN1, ENPP1, SLC2A4, KCNJ11, MTNR1B, PDX1, HNF1A, GCK, RETN, WFS1, CAPN10, IGF2BP2, AKT2, ABCC8, MAPK8IP1, HNF1B, SLC30A8, NEUROD1, INSR, TCF7L2, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A
regulatory region DNA binding (GO:0000975)	-	3.03	0.0	PAX4, NEUROD1, PDX1, AKT2, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A
receptor binding (GO:0005102)	-	2.43	0.003	AKT2, PAX4, HNF1A, ABCC8, INSR, PTPN1, ENPP1, TCF7L2, RETN, IL6, KCNJ11, HMGA1, IRS1, SLC2A2, IRS2, MTNR1B, MAPK8IP1, PPARG, GCGR, HNF4A
chromatin binding (GO:0003682)	-	3.64	0.014	AKT2, NEUROD1, PDX1, TCF7L2, IRS1, IL6, HMGA1, HNF1B, PPARG, HNF4A
nucleic acid binding transcription factor activity (GO:0001071)	-	2.65	0.034	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	31	PPP1R3A, ENPP1, PTPN1, KCNJ11, MTNR1B, PDX1, HNF1A, ABCC8, INSR, RETN, WFS1, CAPN10, GCGR, SLC30A8, PAX4, GPD2, CDKAL1, MAPK8IP1, HNF1B, AKT2, NEUROD1, GCK, SLC2A4, TCF7L2, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A
biological regulation (GO:0065007)	0.39	30	PTPN1, ENPP1, AKT2, KCNJ11, CAPN10, MTNR1B, PDX1, HNF1A, GCK, RETN, WFS1, SLC2A2, GCGR, IGF2BP2, PAX4, ABCC8, MAPK8IP1, HNF1B, SLC30A8, NEUROD1, INSR, SLC2A4, TCF7L2, IRS1, IL6, HMGA1, HNF4A, IRS2, PPARG, LIPC
single-organism process (GO:0044699)	0.48	30	PTPN1, ENPP1, PPP1R3A, KCNJ11, CAPN10, MTNR1B, PDX1, HNF1A, ABCC8, INSR, RETN, WFS1, SLC2A2, GCGR, AKT2, GPD2, HNF1B, PAX4, SLC30A8, NEUROD1, GCK, SLC2A4, TCF7L2, IRS1, IL6, HMGA1, HNF4A, IRS2, PPARG, LIPC
single-organism cellular process (GO:0044763)	0.65	29	PPP1R3A, ENPP1, PTPN1, KCNJ11, MTNR1B, PDX1, HNF1A, ABCC8, INSR, RETN, WFS1, CAPN10, GCGR, AKT2, GPD2, HNF1B, PAX4, SLC30A8, NEUROD1, GCK, SLC2A4, TCF7L2, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A
regulation of biological process (GO:0050789)	0.45	29	PTPN1, ENPP1, PAX4, KCNJ11, CAPN10, MTNR1B, PDX1, HNF1A, GCK, RETN, WFS1, SLC2A2, GCGR, IGF2BP2, AKT2, ABCC8, MAPK8IP1, HNF1B, SLC30A8, NEUROD1, INSR, TCF7L2, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A
metabolic process (GO:0008152)	0.58	28	PPP1R3A, ENPP1, PTPN1, KCNJ11, CAPN10, PDX1, HNF1A, INSR, WFS1, SLC2A2, GCGR, IGF2BP2, AKT2, GPD2, CDKAL1, MAPK8IP1, HNF1B, PAX4, NEUROD1, GCK, SLC2A4, TCF7L2, IRS1, HMGA1, LIPC, IRS2, PPARG, HNF4A
regulation of cellular process (GO:0050794)	0.5	28	PTPN1, ENPP1, PAX4, KCNJ11, CAPN10, MTNR1B, PDX1, HNF1A, GCK, RETN, WFS1, SLC2A2, GCGR, IGF2BP2, AKT2, ABCC8, MAPK8IP1, HNF1B, SLC30A8, NEUROD1, INSR, TCF7L2, IRS1, IL6, HMGA1, IRS2, PPARG, HNF4A
organic substance metabolic process (GO:0071704)	0.63	27	PTPN1, ENPP1, PPP1R3A, KCNJ11, CAPN10, PDX1, HNF1A, INSR, WFS1, SLC2A2, IGF2BP2, AKT2, GPD2, CDKAL1, MAPK8IP1, HNF1B, PAX4, NEUROD1, GCK, SLC2A4, TCF7L2, IRS1, HMGA1, LIPC, IRS2, PPARG, HNF4A
response to stimulus (GO:0050896)	1.22	27	PTPN1, ENPP1, PAX4, CAPN10, PDX1, HNF1A, INSR, RETN, WFS1, SLC2A2, GCGR, AKT2, ABCC8, HNF1B, SLC30A8, NEUROD1, GCK, SLC2A4, KCNJ11, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, TCF7L2, HNF4A
primary metabolic process (GO:0044238)	0.69	26	PTPN1, ENPP1, PPP1R3A, KCNJ11, CAPN10, PDX1, HNF1A, GCK, WFS1, SLC2A2, AKT2, GPD2, CDKAL1, MAPK8IP1, HNF1B, PAX4, NEUROD1, INSR, SLC2A4, TCF7L2, IRS1, HMGA1, LIPC, IRS2, PPARG, HNF4A
response to oxygen-containing compound (GO:1901700)	2.57	24	SLC2A4, ENPP1, PAX4, CAPN10, PDX1, HNF1A, GCK, RETN, SLC2A2, GCGR, AKT2, IRS2, ABCC8, HNF1B, SLC30A8, NEUROD1, INSR, KCNJ11, IRS1, IL6, LIPC, TCF7L2, PPARG, HNF4A
regulation of cell communication (GO:0010646)	1.73	24	PTPN1, ENPP1, WFS1, KCNJ11, MTNR1B, PDX1, HNF1A, GCK, RETN, CAPN10, AKT2, SLC2A2, ABCC8, MAPK8IP1, HNF1B, SLC30A8, NEUROD1, INSR, TCF7L2, IRS1, IL6, IRS2, PPARG, HNF4A
regulation of signaling (GO:0023051)	1.72	24	PTPN1, ENPP1, WFS1, KCNJ11, MTNR1B, PDX1, HNF1A, GCK, RETN, CAPN10, AKT2, SLC2A2, ABCC8, MAPK8IP1, HNF1B, SLC30A8, NEUROD1, INSR, TCF7L2, IRS1, IL6, IRS2, PPARG, HNF4A
macromolecule metabolic process (GO:0043170)	0.83	24	PPP1R3A, ENPP1, PTPN1, CAPN10, PDX1, HNF1A, GCK, WFS1, IGF2BP2, AKT2, CDKAL1, MAPK8IP1, HNF1B, PAX4, NEUROD1, INSR, SLC2A4, TCF7L2, IRS1, HMGA1, LIPC, IRS2, PPARG, HNF4A
response to chemical (GO:0042221)	1.98	24	SLC2A4, ENPP1, PAX4, CAPN10, PDX1, HNF1A, GCK, RETN, SLC2A2, GCGR, AKT2, IRS2, ABCC8, HNF1B, SLC30A8, NEUROD1, INSR, KCNJ11, IRS1, IL6, LIPC, TCF7L2, PPARG, HNF4A
positive regulation of biological process (GO:0048518)	1.2	24	PTPN1, PAX4, CAPN10, MTNR1B, PDX1, HNF1A, GCK, RETN, WFS1, AKT2, ABCC8, MAPK8IP1, HNF1B, SLC30A8, NEUROD1, INSR, KCNJ11, IRS1, IL6, HMGA1, IRS2, PPARG, TCF7L2, HNF4A
negative regulation of biological process (GO:0048519)	1.33	24	PTPN1, ENPP1, PAX4, KCNJ11, MTNR1B, PDX1, HNF1A, GCK, RETN, WFS1, IGF2BP2, AKT2, ABCC8, MAPK8IP1, HNF1B, NEUROD1, INSR, TCF7L2, IRS1, IL6, HMGA1, IRS2, PPARG, HNF4A
regulation of biological quality (GO:0065008)	1.68	24	SLC2A4, ENPP1, CAPN10, MTNR1B, HNF1B, PDX1, HNF1A, INSR, RETN, SLC2A2, GCGR, WFS1, ABCC8, KCNJ11, SLC30A8, NEUROD1, GCK, TCF7L2, IRS1, IL6, LIPC, IRS2, PPARG, HNF4A
response to organic substance (GO:0010033)	2.2	24	SLC2A4, ENPP1, AKT2, KCNJ11, PDX1, HNF1A, GCK, RETN, CAPN10, GCGR, PAX4, SLC2A2, ABCC8, HNF1B, SLC30A8, NEUROD1, INSR, TCF7L2, IRS1, IL6, LIPC, IRS2, PPARG, HNF4A
cellular metabolic process (GO:0044237)	0.69	23	PPP1R3A, ENPP1, PTPN1, TCF7L2, PDX1, HNF1A, INSR, WFS1, GCGR, AKT2, GPD2, CDKAL1, MAPK8IP1, HNF1B, PAX4, NEUROD1, GCK, IRS1, HMGA1, LIPC, IRS2, PPARG, HNF4A
negative regulation of cellular process (GO:0048523)	1.41	23	PTPN1, ENPP1, PAX4, KCNJ11, MTNR1B, PDX1, HNF1A, INSR, WFS1, IGF2BP2, AKT2, ABCC8, MAPK8IP1, HNF1B, NEUROD1, GCK, TCF7L2, IRS1, IL6, HMGA1, IRS2, PPARG, HNF4A
regulation of metabolic process (GO:0019222)	1.02	23	PTPN1, ENPP1, PAX4, TCF7L2, MTNR1B, PDX1, HNF1A, GCK, RETN, WFS1, GCGR, IGF2BP2, AKT2, MAPK8IP1, HNF1B, NEUROD1, INSR, IRS1, IL6, HMGA1, IRS2, PPARG, HNF4A
regulation of primary metabolic process (GO:0080090)	1.08	22	PTPN1, ENPP1, PAX4, TCF7L2, MTNR1B, PDX1, HNF1A, GCK, WFS1, GCGR, IGF2BP2, AKT2, MAPK8IP1, HNF1B, NEUROD1, INSR, IRS1, IL6, HMGA1, IRS2, PPARG, HNF4A
regulation of macromolecule metabolic process (GO:0060255)	1.08	22	PTPN1, ENPP1, WFS1, TCF7L2, PDX1, HNF1A, GCK, RETN, GCGR, IGF2BP2, AKT2, MAPK8IP1, HNF1B, PAX4, NEUROD1, INSR, IRS1, IL6, HMGA1, IRS2, PPARG, HNF4A
regulation of transport (GO:0051049)	2.24	22	PTPN1, ENPP1, WFS1, TCF7L2, MTNR1B, PDX1, HNF1A, GCK, RETN, CAPN10, AKT2, SLC2A2, ABCC8, SLC30A8, NEUROD1, INSR, KCNJ11, IRS1, IL6, IRS2, PPARG, HNF4A
regulation of cellular metabolic process (GO:0031323)	1.07	22	PTPN1, ENPP1, PAX4, TCF7L2, MTNR1B, PDX1, HNF1A, GCK, WFS1, GCGR, IGF2BP2, AKT2, MAPK8IP1, HNF1B, NEUROD1, INSR, IRS1, IL6, HMGA1, IRS2, PPARG, HNF4A
regulation of localization (GO:0032879)	1.94	22	PTPN1, ENPP1, WFS1, KCNJ11, MTNR1B, PDX1, HNF1A, INSR, RETN, SLC2A2, AKT2, ABCC8, SLC30A8, NEUROD1, GCK, CAPN10, IRS1, IL6, IRS2, PPARG, TCF7L2, HNF4A
positive regulation of cellular process (GO:0048522)	1.3	22	PTPN1, WFS1, CAPN10, MTNR1B, PDX1, HNF1A, GCK, RETN, AKT2, MAPK8IP1, HNF1B, PAX4, SLC30A8, NEUROD1, INSR, TCF7L2, IRS1, IL6, HMGA1, IRS2, PPARG, HNF4A
developmental process (GO:0032502)	1.36	20	PAX4, NEUROD1, GPD2, INSR, PPARG, MTNR1B, PDX1, ENPP1, AKT2, RETN, WFS1, IL6, HMGA1, HNF4A, IRS2, HNF1A, HNF1B, IGF2BP2, TCF7L2, LIPC
cellular macromolecule metabolic process (GO:0044260)	0.93	20	AKT2, PPP1R3A, NEUROD1, INSR, GCK, PTPN1, PDX1, MAPK8IP1, PAX4, IRS1, WFS1, TCF7L2, HMGA1, LIPC, IRS2, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
response to endogenous stimulus (GO:0009719)	2.79	19	AKT2, SLC2A4, ABCC8, INSR, GCK, SLC2A2, PDX1, ENPP1, CAPN10, RETN, IL6, KCNJ11, PAX4, HNF4A, IRS2, IRS1, GCGR, PPARG, LIPC
response to nitrogen compound (GO:1901698)	3.12	19	AKT2, PAX4, ABCC8, IRS2, GCK, PDX1, ENPP1, KCNJ11, IRS1, IL6, INSR, SLC2A4, HNF4A, SLC2A2, CAPN10, GCGR, PPARG, LIPC, RETN
negative regulation of cellular metabolic process (GO:0031324)	2.01	19	AKT2, HNF1A, INSR, GCK, IGF2BP2, PTPN1, IRS2, ENPP1, IL6, PDX1, WFS1, TCF7L2, HMGA1, MAPK8IP1, PAX4, HNF1B, PPARG, MTNR1B, HNF4A
negative regulation of metabolic process (GO:0009892)	1.93	19	AKT2, WFS1, HNF1A, INSR, GCK, PTPN1, IGF2BP2, MTNR1B, PDX1, ENPP1, PAX4, IL6, HMGA1, IRS2, HNF1B, MAPK8IP1, PPARG, TCF7L2, HNF4A
regulation of biosynthetic process (GO:0009889)	1.37	19	AKT2, PAX4, NEUROD1, INSR, GCK, IGF2BP2, PDX1, IRS2, ENPP1, WFS1, IRS1, IL6, HMGA1, TCF7L2, HNF1A, HNF1B, MAPK8IP1, PPARG, HNF4A
response to organonitrogen compound (GO:0010243)	3.2	19	AKT2, SLC2A4, ABCC8, INSR, GCK, PDX1, ENPP1, PAX4, IRS1, IL6, KCNJ11, CAPN10, SLC2A2, HNF4A, IRS2, GCGR, PPARG, LIPC, RETN
transport (GO:0006810)	1.51	19	AKT2, SLC30A8, SLC2A4, NEUROD1, ABCC8, GCK, PPARG, PDX1, ENPP1, IL6, KCNJ11, HMGA1, SLC2A2, HNF1A, HNF1B, MAPK8IP1, IGF2BP2, GCGR, LIPC
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	19	AKT2, WFS1, NEUROD1, INSR, GCK, IGF2BP2, PDX1, ENPP1, PAX4, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, MAPK8IP1, PPARG, TCF7L2, HNF4A
chemical homeostasis (GO:0048878)	2.97	19	SLC30A8, SLC2A4, NEUROD1, INSR, GCK, PDX1, ENPP1, IL6, IRS1, KCNJ11, GCGR, WFS1, LIPC, IRS2, HNF1A, MTNR1B, PPARG, TCF7L2, HNF4A
homeostatic process (GO:0042592)	2.61	19	SLC30A8, SLC2A4, NEUROD1, INSR, GCK, PDX1, ENPP1, TCF7L2, IRS1, IL6, KCNJ11, WFS1, LIPC, IRS2, HNF1A, MTNR1B, PPARG, GCGR, HNF4A
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	19	AKT2, WFS1, NEUROD1, INSR, GCK, IGF2BP2, PDX1, ENPP1, PAX4, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, MAPK8IP1, PPARG, TCF7L2, HNF4A
signal transduction (GO:0007165)	1.28	19	AKT2, NEUROD1, INSR, GCK, PTPN1, PDX1, MAPK8IP1, TCF7L2, IRS1, IL6, GCGR, WFS1, IRS2, ABCC8, HNF1A, HNF1B, PPARG, MTNR1B, HNF4A
regulation of cellular biosynthetic process (GO:0031326)	1.38	19	AKT2, NEUROD1, INSR, GCK, PPARG, PDX1, ENPP1, PAX4, IRS1, WFS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, MAPK8IP1, IGF2BP2, TCF7L2, HNF4A
establishment of localization (GO:0051234)	1.48	19	AKT2, SLC30A8, SLC2A4, NEUROD1, ABCC8, GCK, IGF2BP2, PDX1, ENPP1, IL6, KCNJ11, HMGA1, SLC2A2, HNF1A, HNF1B, MAPK8IP1, PPARG, GCGR, LIPC
localization (GO:0051179)	1.4	19	AKT2, SLC30A8, SLC2A4, NEUROD1, ABCC8, GCK, IGF2BP2, PDX1, ENPP1, IL6, KCNJ11, HMGA1, SLC2A2, HNF1A, HNF1B, MAPK8IP1, PPARG, GCGR, LIPC
single-organism developmental process (GO:0044767)	1.49	18	AKT2, PAX4, NEUROD1, GPD2, INSR, PDX1, TCF7L2, RETN, WFS1, IL6, HMGA1, LIPC, IRS2, HNF1A, HNF1B, PPARG, MTNR1B, HNF4A
cellular response to stimulus (GO:0051716)	1.97	18	AKT2, WFS1, NEUROD1, INSR, GCK, PTPN1, ENPP1, SLC2A4, IRS1, IL6, KCNJ11, CAPN10, HMGA1, IRS2, ABCC8, GCGR, PPARG, LIPC
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	18	AKT2, WFS1, NEUROD1, INSR, GCK, IGF2BP2, PTPN1, PDX1, TCF7L2, IL6, HMGA1, MAPK8IP1, PAX4, HNF1B, HNF1A, PPARG, MTNR1B, HNF4A
organic substance biosynthetic process (GO:1901576)	1.34	17	AKT2, SLC2A4, NEUROD1, GPD2, GCK, PDX1, PAX4, IRS1, TCF7L2, HMGA1, LIPC, IRS2, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
regulation of establishment of protein localization (GO:0070201)	3.02	17	SLC30A8, AKT2, NEUROD1, IRS2, GCK, PTPN1, PDX1, CAPN10, IRS1, IL6, KCNJ11, SLC2A2, ABCC8, HNF1A, MTNR1B, TCF7L2, HNF4A
regulation of protein transport (GO:0051223)	3.12	17	SLC30A8, AKT2, NEUROD1, ABCC8, GCK, PTPN1, PDX1, IRS2, TCF7L2, IRS1, IL6, KCNJ11, CAPN10, SLC2A2, HNF1A, MTNR1B, HNF4A
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	17	WFS1, NEUROD1, GCK, INSR, PTPN1, PDX1, AKT2, RETN, IL6, HMGA1, IRS1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	17	AKT2, PAX4, NEUROD1, GCK, INSR, PTPN1, PDX1, TCF7L2, WFS1, IL6, HMGA1, MAPK8IP1, HNF1A, HNF1B, PPARG, MTNR1B, HNF4A
regulation of response to stimulus (GO:0048583)	1.54	17	AKT2, NEUROD1, MAPK8IP1, INSR, PTPN1, PDX1, ENPP1, TCF7L2, IRS1, WFS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, HNF4A
carbohydrate homeostasis (GO:0033500)	4.6	17	SLC30A8, SLC2A4, NEUROD1, INSR, GCK, PDX1, TCF7L2, IRS1, IL6, KCNJ11, WFS1, IRS2, HNF1A, MTNR1B, PPARG, GCGR, HNF4A
regulation of hormone levels (GO:0010817)	3.56	17	SLC30A8, PDX1, NEUROD1, ABCC8, GCK, MTNR1B, IRS2, KCNJ11, IRS1, IL6, CAPN10, RETN, SLC2A2, HNF1A, HNF1B, TCF7L2, HNF4A
glucose homeostasis (GO:0042593)	4.6	17	SLC30A8, SLC2A4, NEUROD1, INSR, GCK, PDX1, TCF7L2, IRS1, IL6, KCNJ11, WFS1, IRS2, HNF1A, GCGR, PPARG, MTNR1B, HNF4A
biosynthetic process (GO:0009058)	1.32	17	AKT2, SLC2A4, NEUROD1, GPD2, GCK, PDX1, PAX4, IRS1, TCF7L2, HMGA1, LIPC, IRS2, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
regulation of protein localization (GO:0032880)	2.88	17	SLC30A8, AKT2, NEUROD1, SLC2A2, GCK, PTPN1, PDX1, IL6, IRS1, KCNJ11, CAPN10, IRS2, ABCC8, HNF1A, MTNR1B, TCF7L2, HNF4A
positive regulation of metabolic process (GO:0009893)	1.74	17	AKT2, NEUROD1, GCK, INSR, PTPN1, PDX1, TCF7L2, RETN, WFS1, IL6, HMGA1, IRS1, IRS2, HNF1A, HNF1B, PPARG, HNF4A
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	16	AKT2, HNF1A, INSR, PPARG, PTPN1, PDX1, ENPP1, PAX4, WFS1, IL6, TCF7L2, HMGA1, MAPK8IP1, HNF1B, IGF2BP2, HNF4A
regulation of secretion (GO:0051046)	3.2	16	SLC30A8, PDX1, NEUROD1, ABCC8, GCK, SLC2A2, CAPN10, IRS1, IL6, KCNJ11, RETN, IRS2, HNF1A, MTNR1B, TCF7L2, HNF4A
regulation of signal transduction (GO:0009966)	1.84	16	AKT2, NEUROD1, MAPK8IP1, INSR, PTPN1, PDX1, ENPP1, TCF7L2, IRS1, IL6, WFS1, IRS2, HNF1A, HNF1B, PPARG, HNF4A
response to hormone (GO:0009725)	3.33	16	AKT2, ABCC8, INSR, GCK, SLC2A2, PDX1, ENPP1, SLC2A4, IRS1, IL6, CAPN10, RETN, IRS2, GCGR, PPARG, LIPC
positive regulation of cellular metabolic process (GO:0031325)	1.81	16	AKT2, NEUROD1, INSR, GCK, PTPN1, PDX1, TCF7L2, IRS1, WFS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, HNF4A
anatomical structure development (GO:0048856)	1.58	16	AKT2, NEUROD1, GPD2, INSR, MTNR1B, PDX1, ENPP1, PAX4, IL6, WFS1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, LIPC
regulation of hormone secretion (GO:0046883)	4.18	16	SLC30A8, PDX1, NEUROD1, ABCC8, GCK, SLC2A2, CAPN10, IRS1, IL6, KCNJ11, RETN, IRS2, HNF1A, MTNR1B, TCF7L2, HNF4A
regulation of secretion by cell (GO:1903530)	3.28	16	SLC30A8, PDX1, NEUROD1, ABCC8, GCK, IRS2, TCF7L2, IRS1, IL6, KCNJ11, CAPN10, RETN, SLC2A2, HNF1A, MTNR1B, HNF4A
regulation of molecular function (GO:0065009)	1.78	16	AKT2, PDX1, NEUROD1, MAPK8IP1, INSR, PTPN1, MTNR1B, IL6, IRS1, KCNJ11, WFS1, IRS2, GCGR, PPARG, TCF7L2, HNF4A
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	15	AKT2, PDX1, NEUROD1, INSR, GCK, IL6, IRS1, WFS1, TCF7L2, HMGA1, IRS2, HNF1A, HNF1B, PPARG, HNF4A
regulation of protein secretion (GO:0050708)	3.77	15	SLC30A8, PDX1, NEUROD1, ABCC8, GCK, SLC2A2, CAPN10, IRS1, IL6, KCNJ11, IRS2, HNF1A, MTNR1B, TCF7L2, HNF4A
positive regulation of transport (GO:0051050)	2.9	15	SLC30A8, PDX1, ABCC8, INSR, GCK, TCF7L2, IRS1, AKT2, IL6, KCNJ11, CAPN10, WFS1, RETN, IRS2, PPARG
positive regulation of biosynthetic process (GO:0009891)	2.29	15	AKT2, NEUROD1, GCK, INSR, PDX1, TCF7L2, IRS1, WFS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, HNF4A
cellular response to organic substance (GO:0071310)	2.78	15	AKT2, SLC2A4, NEUROD1, INSR, GCK, ENPP1, CAPN10, IRS1, IL6, KCNJ11, IRS2, ABCC8, GCGR, PPARG, LIPC
negative regulation of signaling (GO:0023057)	2.65	15	PDX1, NEUROD1, ABCC8, GCK, PTPN1, ENPP1, TCF7L2, IRS1, IL6, KCNJ11, WFS1, MAPK8IP1, MTNR1B, PPARG, HNF4A
single-organism transport (GO:0044765)	2.18	15	AKT2, SLC30A8, SLC2A4, NEUROD1, ABCC8, GCK, PDX1, IL6, KCNJ11, SLC2A2, HNF1A, HNF1B, PPARG, GCGR, LIPC
response to peptide (GO:1901652)	3.94	15	SLC2A4, ABCC8, SLC2A2, INSR, GCK, ENPP1, AKT2, IRS1, IL6, CAPN10, RETN, IRS2, GCGR, PPARG, LIPC
negative regulation of cell communication (GO:0010648)	2.66	15	PDX1, NEUROD1, ABCC8, GCK, PTPN1, ENPP1, TCF7L2, IRS1, IL6, KCNJ11, WFS1, MAPK8IP1, MTNR1B, PPARG, HNF4A
cellular response to chemical stimulus (GO:0070887)	2.57	15	AKT2, SLC2A4, NEUROD1, GCK, ABCC8, CAPN10, ENPP1, IL6, IRS1, KCNJ11, INSR, IRS2, GCGR, PPARG, LIPC
response to peptide hormone (GO:0043434)	4.06	15	SLC2A4, ABCC8, SLC2A2, GCK, ENPP1, INSR, AKT2, IRS1, IL6, CAPN10, RETN, IRS2, GCGR, PPARG, LIPC
regulation of gene expression (GO:0010468)	1.37	15	AKT2, NEUROD1, INSR, PPARG, PDX1, PAX4, WFS1, IL6, TCF7L2, HMGA1, MAPK8IP1, HNF1A, HNF1B, IGF2BP2, HNF4A
single-organism localization (GO:1902578)	2.09	15	AKT2, SLC30A8, SLC2A4, NEUROD1, ABCC8, GCK, PDX1, IL6, KCNJ11, SLC2A2, HNF1A, HNF1B, PPARG, GCGR, LIPC
regulation of peptide transport (GO:0090087)	4.37	14	SLC30A8, PDX1, NEUROD1, IRS2, GCK, CAPN10, IRS1, KCNJ11, SLC2A2, ABCC8, HNF1A, MTNR1B, TCF7L2, HNF4A
single-organism metabolic process (GO:0044710)	1.63	14	GPD2, PPP1R3A, HNF1A, INSR, GCK, PDX1, ENPP1, AKT2, IRS1, KCNJ11, LIPC, IRS2, PPARG, HNF4A
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	14	AKT2, NEUROD1, GCK, INSR, PTPN1, PDX1, IL6, WFS1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
cellular biosynthetic process (GO:0044249)	1.37	14	PAX4, NEUROD1, GCK, PDX1, AKT2, IRS1, TCF7L2, HMGA1, LIPC, IRS2, HNF1A, HNF1B, PPARG, HNF4A
regulation of peptide secretion (GO:0002791)	4.38	14	SLC30A8, PDX1, NEUROD1, SLC2A2, GCK, TCF7L2, IRS1, KCNJ11, CAPN10, IRS2, ABCC8, HNF1A, MTNR1B, HNF4A
regulation of RNA biosynthetic process (GO:2001141)	1.55	14	AKT2, PAX4, NEUROD1, INSR, PDX1, IL6, WFS1, TCF7L2, HMGA1, MAPK8IP1, HNF1A, HNF1B, PPARG, HNF4A
regulation of RNA metabolic process (GO:0051252)	1.52	14	AKT2, PAX4, NEUROD1, INSR, PDX1, TCF7L2, WFS1, IL6, HMGA1, MAPK8IP1, HNF1A, HNF1B, PPARG, HNF4A
regulation of insulin secretion (GO:0050796)	4.57	14	SLC30A8, PDX1, NEUROD1, ABCC8, GCK, SLC2A2, CAPN10, IRS1, KCNJ11, IRS2, HNF1A, MTNR1B, TCF7L2, HNF4A
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	14	AKT2, NEUROD1, INSR, PDX1, PAX4, WFS1, IL6, TCF7L2, HMGA1, MAPK8IP1, HNF1A, HNF1B, PPARG, HNF4A
regulation of programmed cell death (GO:0043067)	2.49	14	AKT2, PAX4, NEUROD1, MAPK8IP1, PTPN1, MTNR1B, PDX1, CAPN10, IL6, WFS1, IRS2, HNF1B, PPARG, TCF7L2
positive regulation of signaling (GO:0023056)	2.41	14	SLC30A8, PDX1, INSR, GCK, PTPN1, MAPK8IP1, IL6, IRS1, AKT2, TCF7L2, CAPN10, RETN, IRS2, MTNR1B
regulation of transcription, DNA-templated (GO:0006355)	1.56	14	AKT2, PAX4, NEUROD1, INSR, PDX1, TCF7L2, WFS1, IL6, HMGA1, MAPK8IP1, HNF1A, HNF1B, PPARG, HNF4A
regulation of peptide hormone secretion (GO:0090276)	4.41	14	SLC30A8, PDX1, NEUROD1, SLC2A2, GCK, TCF7L2, IRS1, KCNJ11, CAPN10, IRS2, ABCC8, HNF1A, MTNR1B, HNF4A
macromolecule biosynthetic process (GO:0009059)	1.61	14	AKT2, SLC2A4, NEUROD1, GCK, PDX1, PAX4, TCF7L2, HMGA1, LIPC, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	14	AKT2, NEUROD1, GCK, INSR, PTPN1, PDX1, TCF7L2, WFS1, IL6, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
positive regulation of cell communication (GO:0010647)	2.41	14	SLC30A8, AKT2, INSR, GCK, PTPN1, PDX1, MAPK8IP1, TCF7L2, IRS1, IL6, RETN, CAPN10, IRS2, MTNR1B
regulation of cell death (GO:0010941)	2.43	14	AKT2, PAX4, NEUROD1, MAPK8IP1, PTPN1, MTNR1B, PDX1, CAPN10, IL6, WFS1, IRS2, HNF1B, PPARG, TCF7L2
regulation of apoptotic process (GO:0042981)	2.5	14	AKT2, PAX4, NEUROD1, MAPK8IP1, PTPN1, MTNR1B, PDX1, CAPN10, IL6, WFS1, IRS2, HNF1B, PPARG, TCF7L2
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	14	AKT2, NEUROD1, INSR, GCK, PDX1, TCF7L2, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, HNF4A
cellular response to endogenous stimulus (GO:0071495)	3.33	13	AKT2, SLC2A4, INSR, GCK, ENPP1, CAPN10, IRS1, IL6, KCNJ11, IRS2, GCGR, PPARG, LIPC
cellular response to oxygen-containing compound (GO:1901701)	3.22	13	AKT2, SLC2A4, NEUROD1, INSR, GCK, ENPP1, CAPN10, IRS1, IL6, KCNJ11, IRS2, GCGR, PPARG
multicellular organismal process (GO:0032501)	1.45	13	AKT2, PAX4, NEUROD1, GPD2, PDX1, KCNJ11, IL6, WFS1, LIPC, HNF1A, HNF1B, MTNR1B, HNF4A
cellular developmental process (GO:0048869)	1.82	13	AKT2, SLC2A4, NEUROD1, INSR, PDX1, IL6, RETN, TCF7L2, HMGA1, PAX4, HNF1B, PPARG, HNF4A
response to stress (GO:0006950)	1.8	13	AKT2, SLC2A4, HNF1A, GCK, PTPN1, PDX1, KCNJ11, WFS1, IL6, HMGA1, GCGR, PPARG, LIPC
nitrogen compound metabolic process (GO:0006807)	1.13	13	PAX4, NEUROD1, GCK, ENPP1, PDX1, TCF7L2, HMGA1, LIPC, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
positive regulation of molecular function (GO:0044093)	2.23	13	AKT2, NEUROD1, IRS2, INSR, PTPN1, PDX1, KCNJ11, IRS1, IL6, WFS1, TCF7L2, GCGR, PPARG
organic substance transport (GO:0071702)	2.15	13	SLC30A8, SLC2A4, NEUROD1, GCK, IGF2BP2, PDX1, AKT2, IL6, SLC2A2, HNF1A, HNF1B, PPARG, LIPC
organic cyclic compound metabolic process (GO:1901360)	1.26	13	PAX4, NEUROD1, GCK, ENPP1, PDX1, TCF7L2, HMGA1, LIPC, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
nucleobase-containing compound metabolic process (GO:0006139)	1.35	12	PAX4, NEUROD1, GCK, ENPP1, PDX1, TCF7L2, HMGA1, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
regulation of phosphate metabolic process (GO:0019220)	2.35	12	AKT2, GCK, INSR, ENPP1, PTPN1, IRS1, IL6, WFS1, IRS2, MTNR1B, MAPK8IP1, HNF4A
response to carbohydrate (GO:0009743)	4.62	12	SLC30A8, PDX1, NEUROD1, SLC2A2, GCK, TCF7L2, KCNJ11, LIPC, IRS2, HNF1A, HNF1B, HNF4A
negative regulation of biosynthetic process (GO:0009890)	2.47	12	WFS1, HNF1A, GCK, IGF2BP2, PDX1, ENPP1, IL6, TCF7L2, HMGA1, PAX4, HNF1B, PPARG
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	12	AKT2, PAX4, NEUROD1, PDX1, TCF7L2, WFS1, IL6, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	12	WFS1, HNF1A, GCK, IGF2BP2, PDX1, ENPP1, TCF7L2, IL6, HMGA1, PAX4, HNF1B, PPARG
negative regulation of cell death (GO:0060548)	2.95	12	AKT2, NEUROD1, IRS2, PTPN1, PDX1, MAPK8IP1, PAX4, IL6, WFS1, TCF7L2, HNF1B, MTNR1B
cellular aromatic compound metabolic process (GO:0006725)	1.3	12	PAX4, NEUROD1, GCK, ENPP1, PDX1, TCF7L2, HMGA1, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
cellular nitrogen compound metabolic process (GO:0034641)	1.22	12	PAX4, NEUROD1, GCK, ENPP1, PDX1, TCF7L2, HMGA1, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
regulation of phosphorus metabolic process (GO:0051174)	2.35	12	AKT2, PTPN1, INSR, GCK, ENPP1, WFS1, IRS1, IL6, IRS2, MTNR1B, MAPK8IP1, HNF4A
cellular response to hormone stimulus (GO:0032870)	3.99	12	AKT2, SLC2A4, INSR, GCK, ENPP1, IL6, IRS1, CAPN10, IRS2, GCGR, PPARG, LIPC
animal organ development (GO:0048513)	2.53	12	PDX1, NEUROD1, GPD2, INSR, WFS1, TCF7L2, IRS2, HNF1A, HNF1B, PPARG, MTNR1B, LIPC
cellular macromolecule biosynthetic process (GO:0034645)	1.66	12	PAX4, NEUROD1, GCK, PDX1, AKT2, TCF7L2, HMGA1, LIPC, HNF1A, HNF1B, PPARG, HNF4A
negative regulation of apoptotic process (GO:0043066)	3.04	12	AKT2, NEUROD1, MAPK8IP1, PTPN1, MTNR1B, PDX1, PAX4, IL6, WFS1, IRS2, HNF1B, TCF7L2
response to insulin (GO:0032868)	4.72	12	SLC2A4, ABCC8, GCK, INSR, ENPP1, AKT2, IRS1, IL6, CAPN10, RETN, IRS2, PPARG
negative regulation of programmed cell death (GO:0043069)	3.02	12	AKT2, PAX4, NEUROD1, MAPK8IP1, PTPN1, PDX1, TCF7L2, IL6, WFS1, IRS2, HNF1B, MTNR1B
heterocycle metabolic process (GO:0046483)	1.31	12	PAX4, NEUROD1, GCK, ENPP1, PDX1, TCF7L2, HMGA1, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	11	AKT2, WFS1, HNF1A, IGF2BP2, PDX1, PAX4, TCF7L2, HMGA1, HNF1B, PPARG, MTNR1B
cell differentiation (GO:0030154)	2.14	11	AKT2, SLC2A4, NEUROD1, INSR, PDX1, PAX4, RETN, TCF7L2, HNF1B, PPARG, HNF4A
nucleic acid metabolic process (GO:0090304)	1.46	11	PAX4, NEUROD1, ENPP1, PDX1, TCF7L2, HMGA1, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
negative regulation of gene expression (GO:0010629)	2.48	11	AKT2, WFS1, HNF1A, INSR, IGF2BP2, PDX1, PAX4, TCF7L2, HMGA1, HNF1B, PPARG
positive regulation of gene expression (GO:0010628)	2.35	11	AKT2, NEUROD1, INSR, PDX1, IL6, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
small molecule metabolic process (GO:0044281)	2.38	11	AKT2, HNF1A, GPD2, GCK, ENPP1, PDX1, KCNJ11, HNF4A, IRS2, PPARG, LIPC
cell surface receptor signaling pathway (GO:0007166)	2.09	11	AKT2, INSR, PTPN1, PDX1, TCF7L2, IRS1, IL6, GCGR, IRS2, HNF1B, MTNR1B
cellular component organization or biogenesis (GO:0071840)	1.22	11	AKT2, HNF1A, INSR, PTPN1, TCF7L2, IL6, HMGA1, LIPC, CAPN10, HNF1B, HNF4A
cellular response to organonitrogen compound (GO:0071417)	3.87	11	SLC2A4, INSR, GCK, ENPP1, AKT2, IRS1, KCNJ11, CAPN10, IRS2, GCGR, PPARG
cellular component organization (GO:0016043)	1.24	11	AKT2, HNF1A, INSR, PTPN1, IL6, TCF7L2, HMGA1, LIPC, CAPN10, HNF1B, HNF4A
negative regulation of molecular function (GO:0044092)	2.74	11	AKT2, MAPK8IP1, INSR, PTPN1, TCF7L2, IL6, WFS1, IRS2, MTNR1B, PPARG, HNF4A
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	11	AKT2, NEUROD1, INSR, PDX1, TCF7L2, IL6, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
negative regulation of transport (GO:0051051)	3.6	11	AKT2, ABCC8, INSR, GCK, ENPP1, IL6, IRS1, KCNJ11, IRS2, MTNR1B, HNF4A
regulation of catalytic activity (GO:0050790)	1.97	11	AKT2, PTPN1, MAPK8IP1, INSR, WFS1, IRS1, IL6, IRS2, GCGR, PPARG, HNF4A
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	11	AKT2, NEUROD1, INSR, PDX1, TCF7L2, IL6, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
regulation of multicellular organismal process (GO:0051239)	1.87	11	NEUROD1, INSR, IGF2BP2, ENPP1, KCNJ11, RETN, IL6, HNF1B, PPARG, MTNR1B, HNF4A
regulation of intracellular signal transduction (GO:1902531)	2.31	11	PDX1, NEUROD1, MAPK8IP1, INSR, PTPN1, TCF7L2, IRS1, IL6, WFS1, IRS2, HNF4A
response to hexose (GO:0009746)	4.82	11	SLC30A8, PDX1, NEUROD1, IRS2, GCK, TCF7L2, KCNJ11, SLC2A2, HNF1A, HNF1B, HNF4A
single-multicellular organism process (GO:0044707)	1.78	11	PAX4, NEUROD1, GPD2, PDX1, AKT2, IL6, WFS1, LIPC, HNF1A, HNF1B, HNF4A
response to external stimulus (GO:0009605)	2.55	11	AKT2, ABCC8, GCK, INSR, PDX1, RETN, IL6, HMGA1, GCGR, PPARG, LIPC
response to monosaccharide (GO:0034284)	4.77	11	SLC30A8, PDX1, NEUROD1, SLC2A2, GCK, TCF7L2, KCNJ11, IRS2, HNF1A, HNF1B, HNF4A
cellular response to nitrogen compound (GO:1901699)	3.79	11	AKT2, SLC2A4, INSR, GCK, ENPP1, KCNJ11, IRS1, CAPN10, IRS2, GCGR, PPARG
positive regulation of RNA metabolic process (GO:0051254)	2.51	11	AKT2, NEUROD1, INSR, PDX1, TCF7L2, IL6, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
response to glucose (GO:0009749)	4.86	11	SLC30A8, PDX1, NEUROD1, SLC2A2, GCK, TCF7L2, KCNJ11, IRS2, HNF1A, HNF1B, HNF4A
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	11	AKT2, NEUROD1, INSR, PDX1, TCF7L2, IL6, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	11	PAX4, HNF1A, IGF2BP2, PDX1, ENPP1, WFS1, IL6, HMGA1, TCF7L2, HNF1B, PPARG
regulation of phosphorylation (GO:0042325)	2.5	10	AKT2, GCK, INSR, ENPP1, PTPN1, IRS1, IL6, IRS2, MAPK8IP1, HNF4A
regulation of cell proliferation (GO:0042127)	2.41	10	PDX1, INSR, TCF7L2, IRS1, IL6, HMGA1, RETN, IRS2, PPARG, HNF4A
regulation of cellular protein metabolic process (GO:0032268)	1.99	10	WFS1, INSR, IGF2BP2, PTPN1, ENPP1, AKT2, IL6, MAPK8IP1, PPARG, HNF4A
carbohydrate metabolic process (GO:0005975)	3.26	10	AKT2, SLC2A4, SLC2A2, GCK, GPD2, PDX1, PPP1R3A, KCNJ11, INSR, IRS2
cellular response to peptide hormone stimulus (GO:0071375)	4.63	10	SLC2A4, INSR, GCK, ENPP1, AKT2, IRS1, CAPN10, IRS2, GCGR, PPARG
negative regulation of signal transduction (GO:0009968)	2.75	10	PDX1, NEUROD1, ENPP1, PTPN1, IRS1, TCF7L2, WFS1, MAPK8IP1, PPARG, HNF4A
protein metabolic process (GO:0019538)	1.45	10	AKT2, HNF1A, MAPK8IP1, INSR, PTPN1, IRS1, CAPN10, WFS1, IRS2, PPARG
response to drug (GO:0042493)	3.71	10	PAX4, NEUROD1, ABCC8, PDX1, IL6, KCNJ11, LIPC, HNF1B, PPARG, HNF4A
negative regulation of response to stimulus (GO:0048585)	2.52	10	PDX1, NEUROD1, ENPP1, PTPN1, IRS1, TCF7L2, WFS1, MAPK8IP1, PPARG, HNF4A
regulation of protein metabolic process (GO:0051246)	1.93	10	WFS1, INSR, IGF2BP2, PTPN1, ENPP1, AKT2, IL6, MAPK8IP1, PPARG, HNF4A
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	10	PAX4, HNF1A, PPARG, ENPP1, PDX1, WFS1, TCF7L2, HMGA1, HNF1B, IGF2BP2
RNA metabolic process (GO:0016070)	1.59	10	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, CDKAL1, HNF1A, HNF1B, PPARG, HNF4A
regulation of cellular component organization (GO:0051128)	2.01	10	AKT2, HNF1A, INSR, ENPP1, PTPN1, IL6, HMGA1, HNF1B, PPARG, HNF4A
phosphate-containing compound metabolic process (GO:0006796)	2.16	10	GPD2, AKT2, GCK, INSR, ENPP1, PTPN1, IRS1, IRS2, MAPK8IP1, LIPC
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	10	AKT2, NEUROD1, PDX1, TCF7L2, IL6, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
cellular response to peptide (GO:1901653)	4.52	10	SLC2A4, INSR, GCK, ENPP1, AKT2, IRS1, CAPN10, IRS2, GCGR, PPARG
phosphorus metabolic process (GO:0006793)	2.15	10	GPD2, AKT2, INSR, GCK, ENPP1, PTPN1, IRS1, IRS2, MAPK8IP1, LIPC
response to organic cyclic compound (GO:0014070)	3.07	10	AKT2, PAX4, INSR, PDX1, KCNJ11, IL6, HNF4A, HNF1B, PPARG, LIPC
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	10	AKT2, HNF1A, PDX1, PAX4, WFS1, TCF7L2, HMGA1, HNF1B, PPARG, MTNR1B
cellular homeostasis (GO:0019725)	3.23	9	SLC30A8, WFS1, NEUROD1, GCK, ENPP1, IL6, KCNJ11, IRS2, MTNR1B
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
RNA biosynthetic process (GO:0032774)	1.84	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
regulation of cellular carbohydrate metabolic process (GO:0010675)	4.81	9	AKT2, GCK, INSR, ENPP1, IRS1, IL6, IRS2, GCGR, HNF4A
regulation of developmental process (GO:0050793)	2.1	9	NEUROD1, INSR, ENPP1, RETN, IL6, HMGA1, HNF1B, PPARG, HNF4A
organic cyclic compound biosynthetic process (GO:1901362)	1.66	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
negative regulation of RNA metabolic process (GO:0051253)	2.66	9	AKT2, HNF1A, PDX1, PAX4, WFS1, TCF7L2, HMGA1, HNF1B, PPARG
positive regulation of response to stimulus (GO:0048584)	2.18	9	AKT2, PDX1, INSR, PTPN1, IL6, IRS1, TCF7L2, HMGA1, MAPK8IP1
regulation of glucose metabolic process (GO:0010906)	5.08	9	AKT2, GCK, INSR, ENPP1, IRS1, IL6, IRS2, GCGR, HNF4A
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
transcription, DNA-templated (GO:0006351)	1.91	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
cellular response to insulin stimulus (GO:0032869)	5.29	9	SLC2A4, GCK, INSR, ENPP1, AKT2, IRS1, CAPN10, IRS2, PPARG
aromatic compound biosynthetic process (GO:0019438)	1.7	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
anatomical structure morphogenesis (GO:0009653)	2.53	9	PAX4, NEUROD1, INSR, PDX1, IL6, HNF1A, HNF1B, IGF2BP2, HNF4A
regulation of carbohydrate metabolic process (GO:0006109)	4.57	9	AKT2, INSR, GCK, ENPP1, IRS1, IL6, IRS2, GCGR, HNF4A
nucleic acid-templated transcription (GO:0097659)	1.91	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
heterocycle biosynthetic process (GO:0018130)	1.7	9	PAX4, NEUROD1, PDX1, TCF7L2, HMGA1, HNF1A, HNF1B, PPARG, HNF4A
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	8	AKT2, INSR, ENPP1, PTPN1, IL6, MAPK8IP1, IGF2BP2, HNF4A
regulation of carbohydrate biosynthetic process (GO:0043255)	5.25	8	AKT2, GCK, INSR, ENPP1, IRS1, IL6, IRS2, HNF4A
negative regulation of protein metabolic process (GO:0051248)	2.82	8	AKT2, INSR, ENPP1, PTPN1, IL6, MAPK8IP1, IGF2BP2, HNF4A
positive regulation of secretion (GO:0051047)	3.85	8	SLC30A8, PDX1, GCK, IL6, RETN, CAPN10, IRS2, TCF7L2
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	8	PTPN1, MAPK8IP1, INSR, ENPP1, IL6, IRS2, MTNR1B, HNF4A
ion transport (GO:0006811)	2.66	8	SLC30A8, HNF1A, ABCC8, GCK, ENPP1, KCNJ11, SLC2A2, PPARG
positive regulation of secretion by cell (GO:1903532)	3.93	8	SLC30A8, PDX1, GCK, IL6, RETN, CAPN10, IRS2, TCF7L2
response to extracellular stimulus (GO:0009991)	3.71	8	AKT2, GCK, INSR, PDX1, IL6, GCGR, PPARG, LIPC
regulation of transferase activity (GO:0051338)	2.88	8	PTPN1, MAPK8IP1, INSR, IRS1, IL6, IRS2, PPARG, HNF4A
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	8	PAX4, HNF1A, PDX1, WFS1, TCF7L2, HMGA1, HNF1B, PPARG
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	8	PAX4, HNF1A, PDX1, WFS1, TCF7L2, HMGA1, HNF1B, PPARG
macromolecule modification (GO:0043412)	1.73	8	AKT2, HNF1A, MAPK8IP1, INSR, PTPN1, IRS1, IRS2, CDKAL1
regulation of multicellular organismal development (GO:2000026)	2.31	8	NEUROD1, INSR, ENPP1, RETN, IL6, HNF1B, PPARG, HNF4A
negative regulation of phosphate metabolic process (GO:0045936)	3.45	8	PTPN1, MAPK8IP1, INSR, ENPP1, IL6, IRS2, MTNR1B, HNF4A
regulation of protein modification process (GO:0031399)	2.32	8	AKT2, INSR, ENPP1, PTPN1, IL6, WFS1, MAPK8IP1, HNF4A
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	8	PAX4, HNF1A, PDX1, WFS1, TCF7L2, HMGA1, HNF1B, PPARG
cellular chemical homeostasis (GO:0055082)	3.4	8	SLC30A8, WFS1, NEUROD1, GCK, ENPP1, KCNJ11, IRS2, MTNR1B
positive regulation of establishment of protein localization (GO:1904951)	3.49	8	SLC30A8, AKT2, IRS2, GCK, PDX1, TCF7L2, IL6, CAPN10
positive regulation of protein transport (GO:0051222)	3.61	8	SLC30A8, AKT2, IRS2, GCK, PDX1, TCF7L2, IL6, CAPN10
positive regulation of catalytic activity (GO:0043085)	2.4	8	AKT2, INSR, PTPN1, IRS1, WFS1, IRS2, GCGR, PPARG
response to nutrient levels (GO:0031667)	3.77	8	AKT2, GCK, INSR, PDX1, IL6, GCGR, PPARG, LIPC
regulation of cellular localization (GO:0060341)	3.03	7	AKT2, PTPN1, PDX1, TCF7L2, IL6, CAPN10, HNF4A
secretion by cell (GO:0032940)	3.59	7	SLC30A8, PDX1, HNF1A, IL6, NEUROD1, GCGR, HNF1B
intracellular signal transduction (GO:0035556)	2.39	7	AKT2, NEUROD1, GCK, PTPN1, PDX1, IRS1, IRS2
regulation of polysaccharide metabolic process (GO:0032881)	5.97	7	AKT2, GCK, INSR, ENPP1, IRS1, IRS2, GCGR
cellular protein metabolic process (GO:0044267)	1.63	7	AKT2, HNF1A, MAPK8IP1, INSR, PTPN1, IRS1, IRS2
single-organism biosynthetic process (GO:0044711)	2.8	7	AKT2, HNF1A, GPD2, GCK, IRS1, IRS2, LIPC
regulation of generation of precursor metabolites and energy (GO:0043467)	5.24	7	AKT2, GCK, INSR, ENPP1, IRS1, IRS2, GCGR
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	7	PAX4, HNF1A, PDX1, TCF7L2, WFS1, HNF1B, PPARG
positive regulation of signal transduction (GO:0009967)	2.5	7	AKT2, INSR, PTPN1, TCF7L2, IRS1, IL6, MAPK8IP1
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	7	AKT2, GCK, INSR, PTPN1, IRS1, IL6, WFS1
regulation of kinase activity (GO:0043549)	3.07	7	PTPN1, MAPK8IP1, INSR, IRS1, IL6, IRS2, HNF4A
nitrogen compound transport (GO:0071705)	3.54	7	SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B, IGF2BP2
regulation of ion transport (GO:0043269)	3.4	7	AKT2, GCK, ABCC8, WFS1, KCNJ11, IRS2, MTNR1B
macromolecule localization (GO:0033036)	2.34	7	SLC30A8, AKT2, HNF1A, PDX1, NEUROD1, HNF1B, PPARG
lipid metabolic process (GO:0006629)	2.68	7	HNF1A, GPD2, IRS1, LIPC, IRS2, PPARG, HNF4A
positive regulation of phosphate metabolic process (GO:0045937)	2.78	7	AKT2, GCK, INSR, PTPN1, IRS1, IL6, WFS1
cellular protein modification process (GO:0006464)	1.79	7	AKT2, HNF1A, MAPK8IP1, INSR, PTPN1, IRS1, IRS2
establishment of protein localization (GO:0045184)	2.53	7	SLC30A8, AKT2, HNF1A, PDX1, NEUROD1, HNF1B, PPARG
protein modification process (GO:0036211)	1.79	7	AKT2, HNF1A, MAPK8IP1, INSR, PTPN1, IRS1, IRS2
positive regulation of hormone secretion (GO:0046887)	4.98	7	SLC30A8, PDX1, GCK, TCF7L2, RETN, CAPN10, IRS2
single-organism carbohydrate metabolic process (GO:0044723)	3.42	7	AKT2, GCK, GPD2, PDX1, PPP1R3A, KCNJ11, IRS2
regulation of glycogen metabolic process (GO:0070873)	6.17	7	AKT2, GCK, INSR, ENPP1, IRS1, IRS2, GCGR
regulation of hydrolase activity (GO:0051336)	2.53	7	AKT2, PTPN1, IRS1, IL6, IRS2, GCGR, PPARG
response to abiotic stimulus (GO:0009628)	2.8	7	AKT2, ABCC8, SLC2A4, RETN, IL6, PPARG, LIPC
secretion (GO:0046903)	3.38	7	SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B, GCGR
negative regulation of phosphorylation (GO:0042326)	3.7	7	PTPN1, MAPK8IP1, INSR, ENPP1, IL6, IRS2, HNF4A
positive regulation of protein secretion (GO:0050714)	4.39	7	SLC30A8, PDX1, IRS2, GCK, TCF7L2, IL6, CAPN10
regulation of response to stress (GO:0080134)	2.53	7	WFS1, PTPN1, PDX1, IL6, HMGA1, MAPK8IP1, PPARG
regulation of glucose transport (GO:0010827)	5.12	7	AKT2, GCK, INSR, ENPP1, IRS1, CAPN10, IRS2
cellular response to stress (GO:0033554)	2.51	7	SLC2A4, WFS1, GCK, PTPN1, IL6, HMGA1, PPARG
response to lipid (GO:0033993)	3.11	7	PDX1, ABCC8, INSR, IL6, KCNJ11, PPARG, LIPC
regulation of protein phosphorylation (GO:0001932)	2.57	7	AKT2, INSR, ENPP1, PTPN1, IL6, MAPK8IP1, HNF4A
positive regulation of catabolic process (GO:0009896)	3.94	6	AKT2, GCK, INSR, PTPN1, IRS1, IRS2
positive regulation of insulin secretion (GO:0032024)	5.57	6	SLC30A8, PDX1, GCK, CAPN10, TCF7L2, IRS2
regulation of catabolic process (GO:0009894)	3.52	6	AKT2, GCK, INSR, PTPN1, IRS1, IRS2
protein localization (GO:0008104)	2.36	6	SLC30A8, PDX1, HNF1A, AKT2, NEUROD1, HNF1B
endocrine pancreas development (GO:0031018)	6.36	6	PAX4, HNF1A, PDX1, IL6, NEUROD1, HNF1B
regulation of cellular catabolic process (GO:0031329)	3.83	6	AKT2, GCK, INSR, PTPN1, IRS1, IRS2
macromolecular complex subunit organization (GO:0043933)	2.14	6	HNF1A, INSR, TCF7L2, HMGA1, HNF1B, LIPC
phosphorylation (GO:0016310)	2.63	6	AKT2, MAPK8IP1, INSR, GCK, IRS1, IRS2
regulation of intracellular transport (GO:0032386)	3.58	6	AKT2, PTPN1, TCF7L2, IL6, CAPN10, HNF4A
positive regulation of glucose metabolic process (GO:0010907)	6.15	6	AKT2, GCK, INSR, IRS1, IRS2, HNF4A
peptide transport (GO:0015833)	5.44	6	SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B
negative regulation of secretion by cell (GO:1903531)	4.55	6	GCK, ABCC8, KCNJ11, IRS1, IL6, MTNR1B
regulation of glucose import (GO:0046324)	5.63	6	AKT2, INSR, ENPP1, IRS1, CAPN10, IRS2
fat cell differentiation (GO:0045444)	5.02	6	AKT2, INSR, SLC2A4, RETN, TCF7L2, PPARG
negative regulation of establishment of protein localization (GO:1904950)	4.39	6	ABCC8, KCNJ11, IRS1, IL6, MTNR1B, HNF4A
negative regulation of protein transport (GO:0051224)	4.44	6	ABCC8, KCNJ11, IRS1, IL6, MTNR1B, HNF4A
negative regulation of catalytic activity (GO:0043086)	3.0	6	AKT2, IRS2, PTPN1, IL6, MAPK8IP1, PPARG
peptide hormone secretion (GO:0030072)	5.69	6	SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B
amide transport (GO:0042886)	5.19	6	SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B
positive regulation of hydrolase activity (GO:0051345)	2.91	6	AKT2, PTPN1, IRS1, IRS2, GCGR, PPARG
regulation of growth (GO:0040008)	3.26	6	WFS1, INSR, ENPP1, HNF1B, PPARG, HNF4A
positive regulation of protein metabolic process (GO:0051247)	2.43	6	WFS1, INSR, PTPN1, AKT2, IL6, PPARG
transmembrane transport (GO:0055085)	2.72	6	SLC30A8, AKT2, ABCC8, SLC2A4, KCNJ11, SLC2A2
hormone secretion (GO:0046879)	5.48	6	SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B
negative regulation of secretion (GO:0051048)	4.44	6	GCK, ABCC8, KCNJ11, IRS1, IL6, MTNR1B
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	6	WFS1, INSR, PTPN1, AKT2, IL6, PPARG
regulation of glucan biosynthetic process (GO:0010962)	6.33	6	AKT2, GCK, INSR, ENPP1, IRS1, IRS2
positive regulation of carbohydrate metabolic process (GO:0045913)	5.4	6	AKT2, GCK, INSR, IRS1, IRS2, HNF4A
regulation of epithelial cell apoptotic process (GO:1904035)	5.63	6	PDX1, NEUROD1, TCF7L2, IL6, WFS1, CAPN10
negative regulation of intracellular signal transduction (GO:1902532)	3.63	6	PDX1, NEUROD1, PTPN1, WFS1, MAPK8IP1, HNF4A
positive regulation of cell proliferation (GO:0008284)	3.01	6	PDX1, INSR, IRS1, IL6, RETN, IRS2
negative regulation of protein phosphorylation (GO:0001933)	3.79	6	PTPN1, INSR, ENPP1, IL6, MAPK8IP1, HNF4A
positive regulation of cellular catabolic process (GO:0031331)	4.15	6	AKT2, GCK, INSR, PTPN1, IRS1, IRS2
hexose metabolic process (GO:0019318)	4.64	6	AKT2, GCK, GPD2, PDX1, KCNJ11, IRS2
signal release (GO:0023061)	4.65	6	SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B
organophosphate metabolic process (GO:0019637)	3.04	6	GCK, GPD2, ENPP1, IRS1, IRS2, LIPC
regulation of cell differentiation (GO:0045595)	2.42	6	PAX4, NEUROD1, ENPP1, IL6, HNF1B, PPARG
positive regulation of peptide hormone secretion (GO:0090277)	5.26	6	SLC30A8, PDX1, GCK, CAPN10, TCF7L2, IRS2
positive regulation of cellular carbohydrate metabolic process (GO:0010676)	5.72	6	AKT2, GCK, INSR, IRS1, IRS2, HNF4A
negative regulation of hormone secretion (GO:0046888)	5.41	6	GCK, ABCC8, KCNJ11, IRS1, IL6, MTNR1B
cellular lipid metabolic process (GO:0044255)	2.92	6	HNF1A, GPD2, IRS1, IRS2, PPARG, LIPC
response to inorganic substance (GO:0010035)	3.56	6	SLC30A8, PDX1, INSR, ABCC8, IL6, LIPC
gland development (GO:0048732)	4.15	6	PDX1, HNF1A, INSR, IRS2, HNF1B, LIPC
generation of precursor metabolites and energy (GO:0006091)	4.07	6	PPP1R3A, GCK, PDX1, ENPP1, AKT2, GCGR
positive regulation of phosphorylation (GO:0042327)	2.9	6	AKT2, GCK, INSR, PTPN1, IRS1, IL6
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	6	WFS1, NEUROD1, IL6, TCF7L2, PPARG, HNF4A
positive regulation of developmental process (GO:0051094)	2.77	6	NEUROD1, INSR, RETN, IL6, HMGA1, PPARG
peptide secretion (GO:0002790)	5.67	6	SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B
monosaccharide metabolic process (GO:0005996)	4.57	6	AKT2, GCK, GPD2, PDX1, KCNJ11, IRS2
regulation of polysaccharide biosynthetic process (GO:0032885)	6.09	6	AKT2, GCK, INSR, ENPP1, IRS1, IRS2
positive regulation of peptide secretion (GO:0002793)	5.22	6	SLC30A8, PDX1, GCK, CAPN10, TCF7L2, IRS2
response to metal ion (GO:0010038)	3.91	6	SLC30A8, PDX1, INSR, ABCC8, IL6, LIPC
hormone transport (GO:0009914)	5.33	6	SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B
regulation of glycogen biosynthetic process (GO:0005979)	6.33	6	AKT2, GCK, INSR, ENPP1, IRS1, IRS2
regulation of type B pancreatic cell apoptotic process (GO:2000674)	7.53	6	PDX1, NEUROD1, TCF7L2, IL6, WFS1, CAPN10
protein transport (GO:0015031)	2.62	6	SLC30A8, PDX1, HNF1A, AKT2, NEUROD1, HNF1B
glucose metabolic process (GO:0006006)	4.94	6	AKT2, GCK, GPD2, PDX1, KCNJ11, IRS2
negative regulation of protein modification process (GO:0031400)	3.4	6	PTPN1, INSR, ENPP1, IL6, MAPK8IP1, HNF4A
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	5	PDX1, TCF7L2, WFS1, PTPN1, MAPK8IP1
positive regulation of fatty acid metabolic process (GO:0045923)	6.23	5	IRS2, AKT2, PPARG, IRS1, HNF4A
regulation of cellular response to stress (GO:0080135)	3.4	5	HMGA1, PDX1, WFS1, PTPN1, MAPK8IP1
organ morphogenesis (GO:0009887)	3.55	5	PAX4, HNF1B, NEUROD1, PDX1, INSR
regulation of apoptotic signaling pathway (GO:2001233)	3.83	5	PDX1, TCF7L2, WFS1, PTPN1, MAPK8IP1
ion homeostasis (GO:0050801)	3.42	5	SLC30A8, MTNR1B, ENPP1, WFS1, GCK
positive regulation of glucose import (GO:0046326)	6.09	5	IRS2, AKT2, CAPN10, IRS1, INSR
protein phosphorylation (GO:0006468)	2.89	5	IRS2, AKT2, IRS1, INSR, MAPK8IP1
carboxylic acid metabolic process (GO:0019752)	3.12	5	HNF1A, PPARG, HNF4A, LIPC, GCK
regulation of cellular protein localization (GO:1903827)	3.43	5	AKT2, IL6, TCF7L2, PTPN1, HNF4A
inorganic ion homeostasis (GO:0098771)	3.43	5	SLC30A8, MTNR1B, ENPP1, WFS1, GCK
anion transport (GO:0006820)	3.71	5	HNF1A, PPARG, SLC2A2, ABCC8, ENPP1
cellular component assembly (GO:0022607)	2.14	5	HNF1B, TCF7L2, HMGA1, INSR, LIPC
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	5	IRS2, PTPN1, IRS1, AKT2, INSR
positive regulation of cell death (GO:0010942)	3.32	5	PPARG, IL6, NEUROD1, PDX1, CAPN10
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	5	IRS2, AKT2, IRS1, PTPN1, INSR
response to purine-containing compound (GO:0014074)	4.67	5	PPARG, IL6, KCNJ11, PAX4, HNF4A
positive regulation of glucose transport (GO:0010828)	5.99	5	IRS2, AKT2, CAPN10, IRS1, INSR
insulin secretion (GO:0030073)	6.09	5	SLC30A8, HNF1A, HNF1B, NEUROD1, PDX1
organic substance catabolic process (GO:1901575)	2.45	5	LIPC, WFS1, ENPP1, GPD2, GCK
regulation of intracellular protein transport (GO:0033157)	3.8	5	AKT2, IL6, TCF7L2, PTPN1, HNF4A
negative regulation of protein secretion (GO:0050709)	5.06	5	IRS1, MTNR1B, KCNJ11, IL6, ABCC8
developmental process involved in reproduction (GO:0003006)	3.36	5	HNF1A, HNF1B, PPARG, HNF4A, INSR
positive regulation of multicellular organismal process (GO:0051240)	2.49	5	PPARG, IL6, NEUROD1, MTNR1B, RETN
negative regulation of transferase activity (GO:0051348)	3.87	5	IRS2, IL6, PPARG, PTPN1, MAPK8IP1
regulation of cellular ketone metabolic process (GO:0010565)	4.67	5	IRS2, AKT2, PPARG, IRS1, HNF4A
carbohydrate transport (GO:0008643)	5.16	5	AKT2, SLC2A4, HNF1A, SLC2A2, GCK
macromolecular complex assembly (GO:0065003)	2.55	5	HNF1B, TCF7L2, HMGA1, LIPC, INSR
rhythmic process (GO:0048511)	4.02	5	PAX4, HNF1B, PPARG, MTNR1B, LIPC
positive regulation of lipid metabolic process (GO:0045834)	4.88	5	IRS2, AKT2, PPARG, IRS1, HNF4A
transcription from RNA polymerase II promoter (GO:0006366)	3.38	5	HNF1A, PDX1, NEUROD1, HMGA1, HNF4A
positive regulation of glycogen biosynthetic process (GO:0045725)	7.02	5	IRS1, AKT2, IRS2, INSR, GCK
response to transition metal nanoparticle (GO:1990267)	4.7	5	SLC30A8, PDX1, ABCC8, LIPC, INSR
positive regulation of cellular component organization (GO:0051130)	2.68	5	HNF1A, HNF1B, PPARG, AKT2, INSR
negative regulation of cell proliferation (GO:0008285)	3.26	5	HMGA1, IL6, PPARG, PDX1, HNF4A
insulin receptor signaling pathway (GO:0008286)	5.33	5	IRS1, PTPN1, INSR, AKT2, IRS2
positive regulation of cell migration (GO:0030335)	3.77	5	IRS2, IL6, AKT2, INSR, RETN
response to cytokine (GO:0034097)	3.84	5	SLC30A8, IL6, KCNJ11, PDX1, INSR
regulation of fatty acid metabolic process (GO:0019217)	5.25	5	IRS2, AKT2, PPARG, IRS1, HNF4A
regulation of lipid metabolic process (GO:0019216)	4.08	5	IRS2, AKT2, PPARG, IRS1, HNF4A
protein secretion (GO:0009306)	4.97	5	SLC30A8, HNF1A, HNF1B, NEUROD1, PDX1
regulation of protein kinase activity (GO:0045859)	3.15	5	IL6, INSR, MAPK8IP1, PTPN1, HNF4A
cellular ion homeostasis (GO:0006873)	3.57	5	SLC30A8, MTNR1B, ENPP1, WFS1, GCK
lipid homeostasis (GO:0055088)	5.0	5	IRS2, PPARG, HNF4A, LIPC, GCK
reproductive process (GO:0022414)	2.55	5	HNF1A, HNF1B, PPARG, HNF4A, INSR
regulation of cellular component movement (GO:0051270)	3.08	5	AKT2, IRS2, IL6, RETN, INSR
regulation of system process (GO:0044057)	3.53	5	NEUROD1, IL6, KCNJ11, MTNR1B, RETN
oxoacid metabolic process (GO:0043436)	3.12	5	HNF1A, PPARG, HNF4A, GCK, LIPC
catabolic process (GO:0009056)	2.38	5	GPD2, WFS1, ENPP1, LIPC, GCK
positive regulation of glycogen metabolic process (GO:0070875)	6.9	5	AKT2, IRS1, IRS2, INSR, GCK
oxidation-reduction process (GO:0055114)	2.91	5	GPD2, AKT2, PPARG, PPP1R3A, GCK
positive regulation of cellular component movement (GO:0051272)	3.71	5	IRS2, IL6, AKT2, INSR, RETN
regulation of locomotion (GO:0040012)	3.12	5	AKT2, IRS2, IL6, RETN, INSR
organonitrogen compound metabolic process (GO:1901564)	2.32	5	ENPP1, HNF1A, HNF4A, LIPC, GCK
organic acid metabolic process (GO:0006082)	3.01	5	HNF1A, PPARG, HNF4A, GCK, LIPC
positive regulation of locomotion (GO:0040017)	3.71	5	IRS2, IL6, AKT2, INSR, RETN
regulation of cell cycle (GO:0051726)	2.93	5	AKT2, TCF7L2, NEUROD1, HNF4A, INSR
regulation of cell migration (GO:0030334)	3.23	5	AKT2, IRS2, IL6, RETN, INSR
carbohydrate derivative metabolic process (GO:1901135)	3.07	5	LIPC, SLC2A4, ENPP1, GPD2, GCK
positive regulation of protein modification process (GO:0031401)	2.7	5	IL6, WFS1, AKT2, INSR, PTPN1
regulation of cell motility (GO:2000145)	3.16	5	IRS2, IL6, AKT2, INSR, RETN
positive regulation of cell motility (GO:2000147)	3.74	5	AKT2, IRS2, IL6, RETN, INSR
epithelial cell differentiation (GO:0030855)	3.98	5	NEUROD1, HNF1B, PDX1, PPARG, AKT2
negative regulation of kinase activity (GO:0033673)	4.22	4	IRS2, IL6, PTPN1, MAPK8IP1
response to glucocorticoid (GO:0051384)	4.63	4	LIPC, IL6, PDX1, INSR
positive regulation of intracellular transport (GO:0032388)	4.08	4	IL6, CAPN10, AKT2, TCF7L2
cellular glucose homeostasis (GO:0001678)	5.48	4	KCNJ11, NEUROD1, IRS2, GCK
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	4	SLC30A8, MTNR1B, WFS1, GCK
regulation of homeostatic process (GO:0032844)	3.65	4	SLC30A8, PDX1, NEUROD1, HNF4A
positive regulation of fatty acid oxidation (GO:0046321)	7.09	4	AKT2, PPARG, IRS2, IRS1
regulation of fatty acid oxidation (GO:0046320)	6.4	4	AKT2, PPARG, IRS2, IRS1
liver development (GO:0001889)	4.98	4	HNF1B, HNF1A, PDX1, LIPC
negative regulation of insulin secretion (GO:0046676)	5.99	4	IRS1, MTNR1B, KCNJ11, ABCC8
negative regulation of epithelial cell apoptotic process (GO:1904036)	6.15	4	PDX1, NEUROD1, TCF7L2, WFS1
reproductive structure development (GO:0048608)	4.08	4	HNF1A, HNF1B, PPARG, INSR
regulation of GTPase activity (GO:0043087)	3.21	4	IRS2, GCGR, AKT2, IRS1
multicellular organism development (GO:0007275)	2.54	4	PAX4, PDX1, NEUROD1, AKT2
regulation of transmembrane transport (GO:0034762)	3.74	4	MTNR1B, KCNJ11, AKT2, IRS2
regulation of MAPK cascade (GO:0043408)	3.22	4	IL6, INSR, PTPN1, MAPK8IP1
single-organism catabolic process (GO:0044712)	3.21	4	LIPC, ENPP1, GPD2, GCK
divalent inorganic cation homeostasis (GO:0072507)	3.9	4	SLC30A8, MTNR1B, WFS1, GCK
cellular carbohydrate metabolic process (GO:0044262)	4.74	4	GPD2, AKT2, PPP1R3A, GCK
positive regulation of GTPase activity (GO:0043547)	3.28	4	IRS2, GCGR, AKT2, IRS1
protein complex subunit organization (GO:0071822)	2.6	4	TCF7L2, HMGA1, LIPC, INSR
hexose transport (GO:0008645)	5.76	4	SLC2A4, HNF1A, SLC2A2, GCK
negative regulation of multicellular organismal process (GO:0051241)	2.84	4	HNF1B, IL6, PPARG, MTNR1B
response to ketone (GO:1901654)	4.53	4	IL6, PPARG, KCNJ11, INSR
glucose transport (GO:0015758)	5.8	4	SLC2A4, HNF1A, SLC2A2, GCK
regulation of transporter activity (GO:0032409)	4.45	4	MTNR1B, PPARG, KCNJ11, INSR
regulation of purine nucleotide metabolic process (GO:1900542)	4.41	4	MTNR1B, WFS1, INSR, GCK
regulation of immune system process (GO:0002682)	2.5	4	IL6, PPARG, PTPN1, IRS2
growth (GO:0040007)	3.8	4	GPD2, IL6, HNF1B, LIPC
response to corticosteroid (GO:0031960)	4.56	4	LIPC, IL6, PDX1, INSR
aging (GO:0007568)	4.16	4	IL6, HMGA1, PDX1, RETN
system process (GO:0003008)	2.3	4	MTNR1B, HNF1A, KCNJ11, WFS1
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	4	MTNR1B, PPARG, GCGR, INSR
positive regulation of programmed cell death (GO:0043068)	3.38	4	NEUROD1, IL6, PPARG, CAPN10
negative regulation of intrinsic apoptotic signaling pathway (GO:2001243)	5.21	4	PDX1, WFS1, PTPN1, MAPK8IP1
regulation of intrinsic apoptotic signaling pathway (GO:2001242)	4.74	4	PDX1, WFS1, PTPN1, MAPK8IP1
embryonic morphogenesis (GO:0048598)	3.72	4	HNF1A, HNF1B, NEUROD1, PDX1
circadian rhythm (GO:0007623)	4.79	4	HNF1B, PAX4, LIPC, MTNR1B
regulation of smooth muscle cell proliferation (GO:0048660)	5.1	4	IL6, PPARG, TCF7L2, RETN
cell proliferation (GO:0008283)	3.23	4	IRS2, IL6, HNF1B, TCF7L2
cellular metal ion homeostasis (GO:0006875)	3.75	4	SLC30A8, MTNR1B, WFS1, GCK
cation transport (GO:0006812)	3.11	4	SLC30A8, KCNJ11, GCK, ABCC8
response to nutrient (GO:0007584)	4.49	4	GCGR, PPARG, PDX1, INSR
protein complex assembly (GO:0006461)	2.78	4	TCF7L2, HMGA1, LIPC, INSR
response to alkaloid (GO:0043279)	4.83	4	IL6, PDX1, PPARG, KCNJ11
regulation of vesicle-mediated transport (GO:0060627)	3.63	4	SLC30A8, AKT2, PPARG, PTPN1
positive regulation of cell differentiation (GO:0045597)	3.01	4	PPARG, IL6, NEUROD1, PAX4
cell fate commitment (GO:0045165)	4.72	4	NEUROD1, IL6, PPARG, TCF7L2
metal ion transport (GO:0030001)	3.36	4	SLC30A8, KCNJ11, ABCC8, GCK
response to acid chemical (GO:0001101)	4.05	4	IL6, PPARG, PDX1, LIPC
cellular cation homeostasis (GO:0030003)	3.6	4	SLC30A8, MTNR1B, WFS1, GCK
metal ion homeostasis (GO:0055065)	3.61	4	SLC30A8, MTNR1B, WFS1, GCK
cation homeostasis (GO:0055080)	3.46	4	SLC30A8, MTNR1B, WFS1, GCK
positive regulation of intracellular signal transduction (GO:1902533)	2.95	4	IL6, TCF7L2, PTPN1, INSR
monocarboxylic acid metabolic process (GO:0032787)	3.57	4	HNF1A, PPARG, GCK, LIPC
negative regulation of peptide hormone secretion (GO:0090278)	5.88	4	IRS1, MTNR1B, KCNJ11, ABCC8
cellular catabolic process (GO:0044248)	2.62	4	WFS1, ENPP1, GPD2, LIPC
lipid biosynthetic process (GO:0008610)	3.49	4	IRS2, HNF1A, IRS1, LIPC
organelle organization (GO:0006996)	2.02	4	PTPN1, HMGA1, TCF7L2, CAPN10
regulation of metal ion transport (GO:0010959)	3.94	4	MTNR1B, ABCC8, WFS1, GCK
single organism reproductive process (GO:0044702)	2.73	4	HNF1A, HNF1B, PPARG, INSR
response to biotic stimulus (GO:0009607)	3.09	4	IL6, HMGA1, WFS1, ABCC8
regulation of lipid transport (GO:0032368)	5.21	4	AKT2, PPARG, IRS2, RETN
cellular response to organic cyclic compound (GO:0071407)	3.93	4	AKT2, IL6, PPARG, KCNJ11
negative regulation of peptide secretion (GO:0002792)	5.84	4	IRS1, MTNR1B, KCNJ11, ABCC8
regulation of ion transmembrane transport (GO:0034765)	3.77	4	MTNR1B, KCNJ11, AKT2, IRS2
negative regulation of type B pancreatic cell apoptotic process (GO:2000675)	8.12	4	PDX1, NEUROD1, WFS1, TCF7L2
positive regulation of apoptotic process (GO:0043065)	3.38	4	NEUROD1, IL6, PPARG, CAPN10
monosaccharide transport (GO:0015749)	5.76	4	SLC2A4, HNF1A, SLC2A2, GCK
regulation of cellular response to insulin stimulus (GO:1900076)	5.65	4	AKT2, ENPP1, PTPN1, IRS1
regulation of nucleotide metabolic process (GO:0006140)	4.38	4	MTNR1B, WFS1, INSR, GCK
positive regulation of protein phosphorylation (GO:0001934)	2.95	4	IL6, AKT2, INSR, PTPN1
response to steroid hormone (GO:0048545)	4.24	4	LIPC, IL6, PDX1, INSR
developmental growth (GO:0048589)	4.05	3	HNF1B, GPD2, LIPC
positive regulation of nitric oxide biosynthetic process (GO:0045429)	5.99	3	IL6, AKT2, INSR
regulation of Wnt signaling pathway (GO:0030111)	3.98	3	HNF1B, HNF1A, TCF7L2
calcium ion homeostasis (GO:0055074)	3.97	3	MTNR1B, WFS1, GCK
small molecule biosynthetic process (GO:0044283)	3.79	3	HNF1A, GPD2, LIPC
negative regulation of response to endoplasmic reticulum stress (GO:1903573)	6.07	3	PDX1, WFS1, PTPN1
positive regulation of protein kinase B signaling (GO:0051897)	5.32	3	IL6, TCF7L2, INSR
positive regulation of nucleotide metabolic process (GO:0045981)	4.85	3	WFS1, GCK, INSR
regulation of defense response (GO:0031347)	3.11	3	IL6, PPARG, PTPN1
negative regulation of transmembrane transport (GO:0034763)	5.38	3	MTNR1B, AKT2, IRS2
hormone-mediated signaling pathway (GO:0009755)	4.66	3	GCGR, PPARG, HNF4A
response to amino acid (GO:0043200)	5.12	3	IL6, PDX1, LIPC
response to external biotic stimulus (GO:0043207)	3.13	3	IL6, HMGA1, ABCC8
posttranscriptional regulation of gene expression (GO:0010608)	3.64	3	IL6, IGF2BP2, AKT2
lipid transport (GO:0006869)	4.24	3	HNF1A, PPARG, LIPC
peptidyl-amino acid modification (GO:0018193)	2.98	3	AKT2, HNF1A, INSR
interspecies interaction between organisms (GO:0044419)	3.08	3	IL6, HMGA1, INSR
cellular response to hexose stimulus (GO:0071331)	5.65	3	KCNJ11, NEUROD1, IRS2
positive regulation of cell development (GO:0010720)	3.57	3	NEUROD1, IL6, PPARG
cellular response to glucose stimulus (GO:0071333)	5.69	3	KCNJ11, NEUROD1, IRS2
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281)	4.43	3	IL6, PPARG, AKT2
regulation of DNA metabolic process (GO:0051052)	3.87	3	IL6, PPARG, INSR
regulation of gluconeogenesis (GO:0006111)	6.07	3	IL6, HNF4A, GCK
organic anion transport (GO:0015711)	4.07	3	HNF1A, PPARG, SLC2A2
regulation of circadian rhythm (GO:0042752)	5.09	3	MTNR1B, PPARG, IL6
regulation of proteolysis (GO:0030162)	3.2	3	IL6, PPARG, AKT2
regulation of embryonic development (GO:0045995)	4.98	3	HNF1B, HNF4A, INSR
glycerolipid metabolic process (GO:0046486)	3.91	3	IRS2, IRS1, LIPC
negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433)	4.82	3	WFS1, TCF7L2, HNF4A
multi-organism process (GO:0051704)	2.65	3	IL6, HMGA1, INSR
vesicle-mediated transport (GO:0016192)	2.72	3	GCGR, ENPP1, MAPK8IP1
cellular response to carbohydrate stimulus (GO:0071322)	5.52	3	KCNJ11, NEUROD1, IRS2
cellular response to monosaccharide stimulus (GO:0071326)	5.65	3	KCNJ11, NEUROD1, IRS2
carbohydrate biosynthetic process (GO:0016051)	4.93	3	AKT2, GPD2, GCK
immune system process (GO:0002376)	2.29	3	ENPP1, IL6, PPARG
negative regulation of cellular response to insulin stimulus (GO:1900077)	6.29	3	PTPN1, ENPP1, IRS1
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	4.35	3	IL6, PTPN1, HNF4A
positive regulation of kinase activity (GO:0033674)	3.54	3	PTPN1, IRS1, INSR
regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235)	6.33	3	PDX1, WFS1, PTPN1
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902236)	6.78	3	PDX1, WFS1, PTPN1
second-messenger-mediated signaling (GO:0019932)	4.65	3	PDX1, NEUROD1, GCK
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	3	PTPN1, INSR, MAPK8IP1
negative regulation of ion transmembrane transport (GO:0034766)	5.47	3	MTNR1B, AKT2, IRS2
cellular polysaccharide metabolic process (GO:0044264)	5.41	3	AKT2, PPP1R3A, GCK
cofactor metabolic process (GO:0051186)	3.91	3	HNF1A, HNF4A, GCK
positive regulation of transferase activity (GO:0051347)	3.31	3	PTPN1, INSR, IRS1
regulation of JAK-STAT cascade (GO:0046425)	4.78	3	IL6, NEUROD1, HNF4A
regulation of anatomical structure size (GO:0090066)	3.78	3	HNF1B, HNF1A, MTNR1B
energy reserve metabolic process (GO:0006112)	5.44	3	AKT2, PPP1R3A, GCK
inorganic cation transmembrane transport (GO:0098662)	3.55	3	SLC30A8, KCNJ11, ABCC8
inorganic ion transmembrane transport (GO:0098660)	3.38	3	SLC30A8, KCNJ11, ABCC8
negative regulation of carbohydrate metabolic process (GO:0045912)	5.76	3	IL6, ENPP1, GCK
positive regulation of reactive oxygen species metabolic process (GO:2000379)	5.29	3	IL6, AKT2, INSR
tissue development (GO:0009888)	3.27	3	HNF1B, ENPP1, INSR
regulation of behavior (GO:0050795)	5.55	3	MTNR1B, IL6, RETN
regulation of reactive oxygen species metabolic process (GO:2000377)	4.71	3	IL6, AKT2, INSR
positive regulation of MAPK cascade (GO:0043410)	3.57	3	IL6, PTPN1, INSR
programmed cell death (GO:0012501)	3.1	3	IL6, AKT2, CAPN10
immune response (GO:0006955)	2.86	3	ENPP1, IL6, PPARG
regulation of neuron death (GO:1901214)	4.19	3	IL6, WFS1, MTNR1B
negative regulation of neuron death (GO:1901215)	4.57	3	MTNR1B, WFS1, IL6
glucan metabolic process (GO:0044042)	5.65	3	AKT2, PPP1R3A, GCK
energy derivation by oxidation of organic compounds (GO:0015980)	4.93	3	AKT2, PPP1R3A, GCK
intracellular transport (GO:0046907)	2.67	3	HMGA1, AKT2, NEUROD1
regulation of collagen metabolic process (GO:0010712)	6.12	3	IL6, PPARG, RETN
positive regulation of nervous system development (GO:0051962)	3.64	3	NEUROD1, IL6, PPARG
regulation of nervous system development (GO:0051960)	3.1	3	NEUROD1, IL6, PPARG
regulation of nucleocytoplasmic transport (GO:0046822)	4.33	3	IL6, TCF7L2, HNF4A
response to organophosphorus (GO:0046683)	4.79	3	PAX4, KCNJ11, HNF4A
camera-type eye development (GO:0043010)	5.36	3	MTNR1B, NEUROD1, GPD2
organic hydroxy compound metabolic process (GO:1901615)	3.84	3	HNF1A, GPD2, LIPC
fatty acid metabolic process (GO:0006631)	4.03	3	HNF1A, PPARG, LIPC
negative regulation of cell growth (GO:0030308)	4.58	3	ENPP1, PPARG, HNF4A
regulation of organelle organization (GO:0033043)	2.72	3	AKT2, HMGA1, INSR
regulation of MAP kinase activity (GO:0043405)	3.95	3	PTPN1, MAPK8IP1, INSR
regulation of nitric oxide biosynthetic process (GO:0045428)	5.76	3	IL6, AKT2, INSR
response to mechanical stimulus (GO:0009612)	4.41	3	IL6, PPARG, RETN
regulation of protein targeting (GO:1903533)	4.0	3	IL6, AKT2, HNF4A
positive regulation of cellular protein localization (GO:1903829)	3.85	3	IL6, AKT2, TCF7L2
regulation of neurogenesis (GO:0050767)	3.21	3	NEUROD1, IL6, PPARG
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	3	HNF1B, IL6, HNF4A
regulation of cell cycle process (GO:0010564)	3.5	3	AKT2, NEUROD1, INSR
regulation of cell development (GO:0060284)	3.01	3	NEUROD1, IL6, PPARG
positive regulation of neurogenesis (GO:0050769)	3.77	3	NEUROD1, IL6, PPARG
response to vitamin (GO:0033273)	5.11	3	PDX1, PPARG, INSR
positive regulation of nitric oxide metabolic process (GO:1904407)	5.99	3	IL6, AKT2, INSR
signal transduction by protein phosphorylation (GO:0023014)	3.79	3	IRS2, IRS1, INSR
cellular localization (GO:0051641)	2.32	3	HMGA1, AKT2, NEUROD1
phospholipid metabolic process (GO:0006644)	3.88	3	IRS2, IRS1, LIPC
cellular glucan metabolic process (GO:0006073)	5.65	3	AKT2, PPP1R3A, GCK
cellular calcium ion homeostasis (GO:0006874)	4.01	3	MTNR1B, WFS1, GCK
regulation of cellular amide metabolic process (GO:0034248)	3.88	3	IL6, IGF2BP2, AKT2
positive regulation of ion transport (GO:0043270)	4.36	3	KCNJ11, WFS1, ABCC8
negative regulation of cell differentiation (GO:0045596)	3.33	3	ENPP1, IL6, PPARG
regulation of cell growth (GO:0001558)	3.75	3	ENPP1, PPARG, HNF4A
eye development (GO:0001654)	5.07	3	MTNR1B, NEUROD1, GPD2
negative regulation of cellular carbohydrate metabolic process (GO:0010677)	5.88	3	IL6, ENPP1, GCK
lipid modification (GO:0030258)	4.37	3	PPARG, IRS2, IRS1
regulation of fat cell differentiation (GO:0045598)	5.04	3	ENPP1, IL6, PPARG
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	3	NEUROD1, IL6, PPARG
regulation of immune response (GO:0050776)	2.98	3	IL6, PPARG, PTPN1
sensory organ development (GO:0007423)	4.82	3	MTNR1B, NEUROD1, GPD2
positive regulation of binding (GO:0051099)	4.88	3	PDX1, NEUROD1, TCF7L2
regulation of binding (GO:0051098)	4.08	3	PDX1, NEUROD1, TCF7L2
regulation of STAT cascade (GO:1904892)	4.78	3	IL6, NEUROD1, HNF4A
regulation of multicellular organismal metabolic process (GO:0044246)	6.09	3	IL6, PPARG, RETN
negative regulation of growth (GO:0045926)	4.24	3	ENPP1, PPARG, HNF4A
glycerophospholipid metabolic process (GO:0006650)	4.13	3	IRS2, IRS1, LIPC
regulation of potassium ion transport (GO:0043266)	5.31	3	MTNR1B, ABCC8, GCK
response to starvation (GO:0042594)	4.69	3	GCGR, PPARG, GCK
cell death (GO:0008219)	3.05	3	IL6, AKT2, CAPN10
morphogenesis of an epithelium (GO:0002009)	4.08	3	HNF1B, IL6, PDX1
regulation of cysteine-type endopeptidase activity (GO:2000116)	4.37	3	IL6, PPARG, AKT2
positive regulation of fatty acid beta-oxidation (GO:0032000)	7.53	3	AKT2, IRS2, IRS1
regulation of response to external stimulus (GO:0032101)	3.06	3	IL6, PPARG, AKT2
positive regulation of reactive oxygen species biosynthetic process (GO:1903428)	5.86	3	IL6, AKT2, INSR
tissue morphogenesis (GO:0048729)	3.87	3	IL6, PDX1, HNF1B
regulation of reactive oxygen species biosynthetic process (GO:1903426)	5.55	3	IL6, AKT2, INSR
negative regulation of protein kinase activity (GO:0006469)	4.29	3	IL6, PTPN1, MAPK8IP1
regulation of peptidase activity (GO:0052547)	3.75	3	IL6, PPARG, AKT2
regulation of endopeptidase activity (GO:0052548)	3.8	3	IL6, PPARG, AKT2
response to tumor necrosis factor (GO:0034612)	4.93	3	IL6, KCNJ11, INSR
apoptotic process (GO:0006915)	3.14	3	IL6, AKT2, CAPN10
positive regulation of intracellular protein transport (GO:0090316)	4.19	3	IL6, AKT2, TCF7L2
regulation of insulin receptor signaling pathway (GO:0046626)	5.97	3	PTPN1, ENPP1, IRS1
negative regulation of insulin receptor signaling pathway (GO:0046627)	6.36	3	PTPN1, ENPP1, IRS1
ion transmembrane transport (GO:0034220)	3.08	3	SLC30A8, KCNJ11, ABCC8
multi-organism cellular process (GO:0044764)	3.14	3	IL6, HMGA1, INSR
establishment of localization in cell (GO:0051649)	2.47	3	HMGA1, AKT2, NEUROD1
cell communication (GO:0007154)	3.04	3	MTNR1B, PPARG, GCK
regulation of protein kinase B signaling (GO:0051896)	4.92	3	IL6, TCF7L2, INSR
response to oxygen levels (GO:0070482)	4.02	3	SLC2A4, PPARG, LIPC
positive regulation of purine nucleotide metabolic process (GO:1900544)	4.85	3	WFS1, INSR, GCK
glycogen metabolic process (GO:0005977)	5.67	3	AKT2, PPP1R3A, GCK
negative regulation of ion transport (GO:0043271)	4.94	3	MTNR1B, AKT2, IRS2
regulation of fatty acid beta-oxidation (GO:0031998)	6.96	3	AKT2, IRS2, IRS1
regulation of lipid catabolic process (GO:0050994)	5.8	3	AKT2, IRS2, IRS1
positive regulation of lipid catabolic process (GO:0050996)	6.51	3	AKT2, IRS2, IRS1
alcohol metabolic process (GO:0006066)	4.2	3	HNF1A, GPD2, LIPC
regulation of cellular component biogenesis (GO:0044087)	3.08	3	HNF1B, HNF1A, HNF4A
sulfur compound metabolic process (GO:0006790)	3.87	3	ENPP1, HNF4A, LIPC
viral process (GO:0016032)	3.15	3	IL6, HMGA1, INSR
polysaccharide metabolic process (GO:0005976)	5.32	3	AKT2, PPP1R3A, GCK
regulation of translation (GO:0006417)	3.96	3	IL6, IGF2BP2, AKT2
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	3	IL6, HMGA1, INSR
cation transmembrane transport (GO:0098655)	3.43	3	SLC30A8, KCNJ11, ABCC8
nuclear transport (GO:0051169)	4.2	2	HMGA1, NEUROD1
response to growth factor (GO:0070848)	4.14	2	IL6, INSR
detection of chemical stimulus (GO:0009593)	3.49	2	PDX1, GCK
organophosphate catabolic process (GO:0046434)	5.03	2	ENPP1, LIPC
cholesterol transport (GO:0030301)	5.88	2	HNF1A, LIPC
anatomical structure homeostasis (GO:0060249)	4.25	2	IL6, HNF1A
positive regulation of reproductive process (GO:2000243)	5.8	2	RETN, INSR
regulation of reproductive process (GO:2000241)	4.88	2	RETN, INSR
activation of protein kinase activity (GO:0032147)	4.08	2	PTPN1, INSR
regulation of protein import into nucleus, translocation (GO:0033158)	6.68	2	IL6, HNF4A
regulation of cyclic nucleotide metabolic process (GO:0030799)	4.69	2	MTNR1B, WFS1
chromatin organization (GO:0006325)	3.28	2	HMGA1, HNF1A
negative regulation of neuron apoptotic process (GO:0043524)	4.82	2	MTNR1B, WFS1
positive regulation of chemotaxis (GO:0050921)	4.94	2	IL6, AKT2
small molecule catabolic process (GO:0044282)	3.99	2	GPD2, GCK
response to zinc ion (GO:0010043)	5.67	2	SLC30A8, ABCC8
cellular response to biotic stimulus (GO:0071216)	4.76	2	IL6, WFS1
carbohydrate transmembrane transport (GO:0034219)	6.47	2	SLC2A4, SLC2A2
stem cell differentiation (GO:0048863)	5.72	2	HNF1B, PDX1
negative regulation of cell cycle (GO:0045786)	3.67	2	TCF7L2, HNF4A
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	2	MTNR1B, GCK
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	2	ENPP1, GCK
response to virus (GO:0009615)	4.21	2	IL6, HMGA1
MAPK cascade (GO:0000165)	3.91	2	IRS2, IRS1
kidney development (GO:0001822)	4.79	2	HNF1B, WFS1
negative regulation of multicellular organismal metabolic process (GO:0044252)	7.24	2	IL6, PPARG
regulation of neuron differentiation (GO:0045664)	3.39	2	IL6, NEUROD1
positive regulation of neuron differentiation (GO:0045666)	3.98	2	IL6, NEUROD1
negative regulation of fat cell differentiation (GO:0045599)	5.99	2	IL6, ENPP1
phosphatidylinositol biosynthetic process (GO:0006661)	4.94	2	IRS2, IRS1
regulation of circadian sleep/wake cycle, sleep (GO:0045187)	6.59	2	IL6, MTNR1B
glandular epithelial cell differentiation (GO:0002067)	6.51	2	PDX1, NEUROD1
columnar/cuboidal epithelial cell differentiation (GO:0002065)	5.84	2	PDX1, NEUROD1
protein oligomerization (GO:0051259)	3.71	2	LIPC, INSR
positive regulation of DNA metabolic process (GO:0051054)	4.49	2	IL6, INSR
monocarboxylic acid transport (GO:0015718)	5.07	2	HNF1A, PPARG
transcription initiation from RNA polymerase II promoter (GO:0006367)	4.7	2	PPARG, HNF4A
organ regeneration (GO:0031100)	5.3	2	PDX1, PPARG
regulation of protein complex assembly (GO:0043254)	3.83	2	HNF1B, HNF1A
response to activity (GO:0014823)	5.47	2	AKT2, INSR
cellular response to extracellular stimulus (GO:0031668)	4.57	2	PPARG, GCK
regulation of glycoprotein metabolic process (GO:1903018)	5.97	2	TCF7L2, INSR
positive regulation of homeostatic process (GO:0032846)	4.38	2	PDX1, HNF4A
response to calcium ion (GO:0051592)	4.98	2	IL6, LIPC
secondary alcohol metabolic process (GO:1902652)	5.0	2	HNF1A, LIPC
response to cAMP (GO:0051591)	5.08	2	PAX4, HNF4A
phosphatidylinositol metabolic process (GO:0046488)	4.46	2	IRS2, IRS1
regionalization (GO:0003002)	4.24	2	HNF1B, NEUROD1
detection of glucose (GO:0051594)	8.63	2	PDX1, GCK
regulation of DNA-templated transcription, initiation (GO:2000142)	6.29	2	HNF1B, HNF1A
regulation of acute inflammatory response (GO:0002673)	5.41	2	IL6, PPARG
divalent metal ion transport (GO:0070838)	4.15	2	SLC30A8, GCK
purine ribonucleoside metabolic process (GO:0046128)	4.33	2	ENPP1, GCK
response to other organism (GO:0051707)	3.48	2	IL6, HMGA1
regulation of kidney size (GO:0035564)	8.12	2	HNF1B, HNF1A
regulation of anion transmembrane transport (GO:1903959)	6.36	2	AKT2, IRS2
regulation of coenzyme metabolic process (GO:0051196)	5.8	2	GCK, INSR
positive regulation of coenzyme metabolic process (GO:0051197)	7.02	2	GCK, INSR
positive regulation of cofactor metabolic process (GO:0051194)	7.02	2	INSR, GCK
cellular response to nutrient levels (GO:0031669)	4.7	2	PPARG, GCK
detection of monosaccharide stimulus (GO:0034287)	8.63	2	PDX1, GCK
regulation of cofactor metabolic process (GO:0051193)	5.8	2	GCK, INSR
endoplasmic reticulum unfolded protein response (GO:0030968)	5.07	2	PTPN1, WFS1
regulation of ATP metabolic process (GO:1903578)	5.82	2	INSR, GCK
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	4.62	2	IL6, PTPN1
SMAD protein signal transduction (GO:0060395)	5.65	2	HNF1A, HNF4A
regulation of collagen biosynthetic process (GO:0032965)	6.26	2	IL6, PPARG
positive regulation of organelle organization (GO:0010638)	3.38	2	AKT2, INSR
organic acid biosynthetic process (GO:0016053)	4.26	2	HNF1A, LIPC
regulation of DNA replication (GO:0006275)	5.02	2	IL6, INSR
negative regulation of gluconeogenesis (GO:0045721)	7.16	2	IL6, GCK
purine nucleotide metabolic process (GO:0006163)	4.09	2	ENPP1, GCK
positive regulation of lymphocyte activation (GO:0051251)	4.07	2	IL6, IRS2
regulation of neuron apoptotic process (GO:0043523)	4.47	2	MTNR1B, WFS1
regulation of lipid storage (GO:0010883)	6.02	2	IL6, PPARG
positive regulation of glycolytic process (GO:0045821)	7.09	2	INSR, GCK
regulation of protein import (GO:1904589)	4.52	2	IL6, HNF4A
regulation of chemotaxis (GO:0050920)	4.53	2	IL6, AKT2
negative regulation of JAK-STAT cascade (GO:0046426)	5.92	2	NEUROD1, HNF4A
negative regulation of lipid storage (GO:0010888)	6.9	2	IL6, PPARG
regulation of transcription initiation from RNA polymerase II promoter (GO:0060260)	6.59	2	HNF1B, HNF1A
positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	6.9	2	HNF1B, HNF1A
embryonic organ morphogenesis (GO:0048562)	4.92	2	HNF1B, NEUROD1
negative regulation of transporter activity (GO:0032410)	5.59	2	MTNR1B, INSR
regulation of ion transmembrane transporter activity (GO:0032412)	4.55	2	MTNR1B, KCNJ11
organic hydroxy compound transport (GO:0015850)	4.96	2	HNF1A, LIPC
nucleoside triphosphate metabolic process (GO:0009141)	4.61	2	ENPP1, GCK
regulation of DNA binding (GO:0051101)	5.21	2	PDX1, NEUROD1
glucose import (GO:0046323)	7.24	2	SLC2A4, HNF1A
morphogenesis of a branching structure (GO:0001763)	4.71	2	HNF1B, IL6
positive regulation of mononuclear cell proliferation (GO:0032946)	4.84	2	IL6, IRS2
regulation of mononuclear cell proliferation (GO:0032944)	4.45	2	IL6, IRS2
positive regulation of DNA binding (GO:0043388)	6.02	2	PDX1, NEUROD1
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	2	PTPN1, INSR
negative regulation of protein serine/threonine kinase activity (GO:0071901)	4.92	2	PTPN1, MAPK8IP1
cellular polysaccharide biosynthetic process (GO:0033692)	6.02	2	AKT2, GCK
divalent inorganic cation transport (GO:0072511)	4.13	2	SLC30A8, GCK
monocarboxylic acid biosynthetic process (GO:0072330)	4.74	2	HNF1A, LIPC
regulation of circadian sleep/wake cycle (GO:0042749)	6.51	2	MTNR1B, IL6
regulation of mitotic cell cycle (GO:0007346)	3.71	2	HNF4A, INSR
regulation of cation transmembrane transport (GO:1904062)	4.4	2	MTNR1B, KCNJ11
negative regulation of hydrolase activity (GO:0051346)	3.74	2	IL6, AKT2
positive regulation of type B pancreatic cell apoptotic process (GO:2000676)	8.34	2	IL6, CAPN10
cellular response to tumor necrosis factor (GO:0071356)	5.19	2	IL6, KCNJ11
morphogenesis of a branching epithelium (GO:0061138)	4.77	2	IL6, HNF1B
regulation of circadian sleep/wake cycle, non-REM sleep (GO:0045188)	7.24	2	IL6, MTNR1B
positive regulation of transmission of nerve impulse (GO:0051971)	7.65	2	MTNR1B, IL6
positive regulation of immune system process (GO:0002684)	2.96	2	IL6, IRS2
regulation of glycolytic process (GO:0006110)	6.26	2	INSR, GCK
phosphatidylinositol phosphorylation (GO:0046854)	5.19	2	IRS2, IRS1
glucose transmembrane transport (GO:1904659)	6.84	2	SLC2A4, SLC2A2
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187)	4.6	2	MTNR1B, GCGR
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	2	HNF1B, HNF1A
hexose transmembrane trans