regulation of secretion (GO:0051046) | - | 3.2 | 0.0 | SLC30A8, SLC2A4, NEUROD1, INSR, GCK, PTPN1, PDX1, IRS2, SLC2A2, TCF7L2, RETN, IL6, KCNJ11, IRS1, CAPN10, ABCC8, HNF1A, GCGR, PPARG, MTNR1B, HNF4A |
positive regulation of secretion (GO:0051047) | - | 3.85 | 0.002 | SLC30A8, PDX1, INSR, GCK, TCF7L2, IRS1, IL6, CAPN10, RETN, IRS2, PPARG |
regulation of transport (GO:0051049) | - | 2.24 | 0.0 | SLC30A8, PDX1, NEUROD1, INSR, GCK, SLC2A2, PTPN1, ENPP1, TCF7L2, IRS1, AKT2, IL6, KCNJ11, CAPN10, WFS1, RETN, IRS2, ABCC8, MTNR1B, PPARG, HNF4A |
positive regulation of hormone secretion (GO:0046887) | - | 4.98 | 0.0 | SLC30A8, PDX1, INSR, GCK, IL6, RETN, CAPN10, IRS2, PPARG, TCF7L2 |
regulation of glycogen biosynthetic process (GO:0005979) | - | 6.33 | 0.0 | AKT2, GCK, INSR, ENPP1, IRS1, IRS2 |
epithelial cell differentiation (GO:0030855) | - | 3.98 | 0.0 | AKT2, PDX1, NEUROD1, GPD2, PTPN1, TCF7L2, IRS1, IL6, HMGA1, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
negative regulation of cell death (GO:0060548) | - | 2.95 | 0.0 | PAX4, NEUROD1, MAPK8IP1, INSR, PTPN1, PDX1, IL6, IRS1, WFS1, TCF7L2, HMGA1, LIPC, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
regulation of protein kinase activity (GO:0045859) | - | 3.15 | 0.001 | PDX1, NEUROD1, ABCC8, INSR, PTPN1, MAPK8IP1, TCF7L2, RETN, IL6, WFS1, IRS1, IRS2, MTNR1B, PPARG, GCGR, HNF4A |
regulation of phosphorylation (GO:0042325) | - | 2.5 | 0.04 | AKT2, PTPN1, GCK, INSR, ENPP1, WFS1, IRS1, IL6, IRS2, MAPK8IP1 |
positive regulation of phosphorylation (GO:0042327) | - | 2.9 | 0.0 | AKT2, PDX1, NEUROD1, INSR, GCK, PTPN1, MAPK8IP1, IL6, IRS1, WFS1, TCF7L2, HMGA1, RETN, IRS2, MTNR1B, PPARG, GCGR, HNF4A |
detection of monosaccharide stimulus (GO:0034287) | - | 8.63 | 0.015 | PDX1, GCK |
response to monosaccharide (GO:0034284) | - | 4.77 | 0.0 | SLC30A8, PDX1, NEUROD1, GCK, TCF7L2, IRS1, IL6, KCNJ11, IRS2, HNF1A, HNF1B, PPARG, HNF4A |
positive regulation of organelle organization (GO:0010638) | - | 3.38 | 0.001 | AKT2, PTPN1, ABCC8, INSR, TCF7L2, IRS1, IL6, IRS2, MTNR1B, PPARG, GCGR, HNF4A |
positive regulation of glycolytic process (GO:0045821) | - | 7.09 | 0.001 | IRS2, PPARG, GCK, INSR |
positive regulation of catabolic process (GO:0009896) | - | 3.94 | 0.047 | IRS2, AKT2, IRS1, GCK, INSR |
negative regulation of metabolic process (GO:0009892) | - | 1.93 | 0.049 | PAX4, GCK, IGF2BP2, PTPN1, PDX1, ENPP1, IL6, TCF7L2, HMGA1, MAPK8IP1, HNF1B, PPARG |
positive regulation of metabolic process (GO:0009893) | - | 1.74 | 0.002 | AKT2, NEUROD1, INSR, GCK, PDX1, TCF7L2, IRS1, WFS1, IL6, HMGA1, RETN, IRS2, HNF1A, HNF1B, PPARG, HNF4A |
negative regulation of biosynthetic process (GO:0009890) | - | 2.47 | 0.038 | PAX4, GCK, IGF2BP2, PDX1, ENPP1, TCF7L2, IL6, HMGA1, HNF1B, PPARG |
positive regulation of biosynthetic process (GO:0009891) | - | 2.29 | 0.0 | AKT2, PDX1, NEUROD1, INSR, GCK, TCF7L2, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, HNF4A |
embryonic organ development (GO:0048568) | NEW | 4.86 | 0.023 | AKT2, IRS1, IL6, HMGA1, IRS2, PPARG, HNF4A |
regulation of glucose metabolic process (GO:0010906) | - | 5.08 | 0.0 | AKT2, INSR, GCK, ENPP1, TCF7L2, IRS1, IL6, IRS2, GCGR, PPARG |
positive regulation of glucose metabolic process (GO:0010907) | - | 6.15 | 0.0 | AKT2, GCK, INSR, IRS1, TCF7L2, IRS2 |
positive regulation of protein serine/threonine kinase activity (GO:0071902) | - | 4.06 | 0.004 | NEUROD1, MAPK8IP1, INSR, TCF7L2, IRS1, IL6, IRS2, GCGR, PPARG, HNF4A |
positive regulation of triglyceride biosynthetic process (GO:0010867) | NEW | 7.16 | 0.023 | TCF7L2, PPARG, HNF4A |
insulin secretion (GO:0030073) | - | 6.09 | 0.0 | SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B, PPARG |
positive regulation of transferase activity (GO:0051347) | - | 3.31 | 0.0 | PDX1, NEUROD1, INSR, GCK, PTPN1, MAPK8IP1, TCF7L2, IRS1, IL6, WFS1, RETN, IRS2, MTNR1B, PPARG, GCGR, HNF4A |
positive regulation of hydrolase activity (GO:0051345) | - | 2.91 | 0.029 | SLC2A4, NEUROD1, ABCC8, INSR, PTPN1, MAPK8IP1, AKT2, IRS1, IL6, GCGR, WFS1, IRS2, MTNR1B, PPARG, TCF7L2 |
hexose transport (GO:0008645) | - | 5.76 | 0.02 | IL6, HNF1A, SLC2A4, GCK, SLC2A2 |
intracellular protein transport (GO:0006886) | NEW | 3.2 | 0.037 | AKT2, NEUROD1, MAPK8IP1, KCNJ11, IRS1, IL6, GCGR, WFS1, IRS2, MTNR1B, PPARG, TCF7L2 |
carbohydrate transport (GO:0008643) | - | 5.16 | 0.002 | AKT2, HNF1A, GCK, SLC2A4, IL6, SLC2A2 |
regulation of type B pancreatic cell apoptotic process (GO:2000674) | - | 7.53 | 0.0 | PDX1, NEUROD1, TCF7L2, IL6, WFS1, CAPN10 |
energy reserve metabolic process (GO:0006112) | - | 5.44 | 0.0 | AKT2, SLC2A4, ABCC8, GCK, PPP1R3A, TCF7L2, IRS1, KCNJ11, SLC2A2, GCGR, PPARG |
regulation of glycolytic process (GO:0006110) | - | 6.26 | 0.01 | IRS2, PPARG, GCK, INSR |
positive regulation of carbohydrate metabolic process (GO:0045913) | - | 5.4 | 0.0 | AKT2, GCK, INSR, IRS1, TCF7L2, IRS2, PPARG |
negative regulation of carbohydrate metabolic process (GO:0045912) | - | 5.76 | 0.0 | GCK, INSR, ENPP1, IRS1, IL6, PPARG |
lipid metabolic process (GO:0006629) | - | 2.68 | 0.0 | AKT2, LIPC, PDX1, NEUROD1, MAPK8IP1, GPD2, PTPN1, SLC2A4, RETN, IL6, KCNJ11, GCGR, HMGA1, IRS1, IRS2, MTNR1B, PPARG, TCF7L2, HNF4A |
regulation of biosynthetic process (GO:0009889) | - | 1.37 | 0.019 | AKT2, PAX4, NEUROD1, INSR, GCK, IGF2BP2, PDX1, IRS2, ENPP1, WFS1, IRS1, IL6, HMGA1, TCF7L2, HNF1A, HNF1B, MAPK8IP1, PPARG, HNF4A |
tissue development (GO:0009888) | - | 3.27 | 0.0 | AKT2, PAX4, NEUROD1, INSR, PTPN1, PDX1, ENPP1, PPP1R3A, IRS1, IL6, GCGR, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
positive regulation of MAPK cascade (GO:0043410) | - | 3.57 | 0.009 | PDX1, NEUROD1, INSR, PTPN1, TCF7L2, IRS1, IL6, RETN, IRS2, GCGR, PPARG |
single-organism carbohydrate metabolic process (GO:0044723) | - | 3.42 | 0.016 | GPD2, PPP1R3A, HNF1A, INSR, GCK, PDX1, TCF7L2, IRS1, AKT2, IL6, KCNJ11, IRS2, GCGR, PPARG, HNF4A |
leukocyte differentiation (GO:0002521) | NEW | 4.13 | 0.038 | PDX1, NEUROD1, PTPN1, TCF7L2, IRS1, IL6, GCGR, PPARG, HNF4A |
glucan metabolic process (GO:0044042) | - | 5.65 | 0.005 | PPP1R3A, TCF7L2, AKT2, GCK |
positive regulation of macromolecule biosynthetic process (GO:0010557) | - | 2.39 | 0.0 | AKT2, NEUROD1, GCK, INSR, PDX1, TCF7L2, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, HNF4A |
regulation of macromolecule biosynthetic process (GO:0010556) | - | 1.43 | 0.009 | PAX4, NEUROD1, INSR, GCK, PPARG, PDX1, ENPP1, AKT2, IRS1, WFS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, MAPK8IP1, IGF2BP2, TCF7L2, HNF4A |
response to alcohol (GO:0097305) | - | 4.58 | 0.0 | PPP1R3A, ABCC8, INSR, PTPN1, MAPK8IP1, SLC2A4, RETN, IL6, KCNJ11, IRS1, IRS2, GCGR, PPARG, TCF7L2, HNF4A |
positive regulation of fatty acid beta-oxidation (GO:0032000) | - | 7.53 | 0.001 | AKT2, PPARG, IRS2, IRS1 |
regulation of developmental growth (GO:0048638) | - | 4.04 | 0.015 | AKT2, INSR, PTPN1, TCF7L2, IRS1, IL6, HNF1B, GCGR |
response to organic cyclic compound (GO:0014070) | - | 3.07 | 0.0 | AKT2, SLC2A4, NEUROD1, ABCC8, GCK, PTPN1, PDX1, MAPK8IP1, PPP1R3A, RETN, IL6, KCNJ11, INSR, IRS1, IRS2, PAX4, GCGR, HNF1A, PPARG, TCF7L2, HNF4A |
establishment of localization (GO:0051234) | - | 1.48 | 0.001 | AKT2, SLC30A8, WFS1, NEUROD1, ABCC8, GCK, IGF2BP2, PDX1, ENPP1, IL6, KCNJ11, GCGR, SLC2A4, SLC2A2, HNF1A, HNF1B, MAPK8IP1, PPARG, TCF7L2, LIPC |
regulation of hormone levels (GO:0010817) | - | 3.56 | 0.0 | SLC30A8, PDX1, NEUROD1, PTPN1, IRS1, IL6, HMGA1, HNF1A, HNF1B, PPARG, HNF4A |
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) | - | 3.12 | 0.0 | AKT2, SLC2A4, NEUROD1, MAPK8IP1, MTNR1B, PDX1, PAX4, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
regulation of cell development (GO:0060284) | - | 3.01 | 0.0 | SLC2A4, NEUROD1, MAPK8IP1, INSR, PTPN1, MTNR1B, KCNJ11, RETN, IL6, GCGR, HMGA1, IRS1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
positive regulation of cell proliferation (GO:0008284) | - | 3.01 | 0.0 | AKT2, NEUROD1, SLC2A2, INSR, PTPN1, PDX1, MAPK8IP1, KCNJ11, IRS1, IL6, GCGR, HMGA1, RETN, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
negative regulation of cell proliferation (GO:0008285) | - | 3.26 | 0.024 | AKT2, PDX1, HNF1A, INSR, IL6, IRS1, TCF7L2, HMGA1, RETN, IRS2, HNF1B, PPARG, GCGR, HNF4A |
insulin receptor signaling pathway (GO:0008286) | - | 5.33 | 0.01 | AKT2, IRS2, PTPN1, IRS1, INSR |
cell proliferation (GO:0008283) | - | 3.23 | 0.002 | AKT2, NEUROD1, INSR, PTPN1, PDX1, TCF7L2, RETN, IL6, HMGA1, IRS1, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
cellular metal ion homeostasis (GO:0006875) | - | 3.75 | 0.001 | SLC30A8, PTPN1, INSR, GCK, WFS1, RETN, IL6, IRS2, HNF1B, PPARG, GCGR |
neurological system process (GO:0050877) | - | 2.64 | 0.006 | AKT2, SLC2A4, NEUROD1, ABCC8, INSR, PTPN1, PDX1, MAPK8IP1, IL6, RETN, KCNJ11, WFS1, IRS1, IRS2, HNF1A, PPARG |
cellular ion homeostasis (GO:0006873) | - | 3.57 | 0.0 | SLC30A8, PTPN1, INSR, GCK, ENPP1, WFS1, RETN, IL6, IRS1, IRS2, HNF1B, PPARG, GCGR |
regulation of hormone secretion (GO:0046883) | - | 4.18 | 0.0 | SLC30A8, PDX1, NEUROD1, SLC2A2, GCK, CAPN10, SLC2A4, RETN, IL6, KCNJ11, INSR, GCGR, IRS1, IRS2, ABCC8, MTNR1B, PPARG, TCF7L2, HNF4A |
regulation of cellular carbohydrate metabolic process (GO:0010675) | - | 4.81 | 0.0 | AKT2, NEUROD1, INSR, GCK, ENPP1, IL6, IRS1, TCF7L2, IRS2, GCGR, PPARG, HNF4A |
positive regulation of cellular carbohydrate metabolic process (GO:0010676) | - | 5.72 | 0.0 | AKT2, GCK, INSR, IRS1, TCF7L2, IRS2, PPARG |
negative regulation of cellular carbohydrate metabolic process (GO:0010677) | - | 5.88 | 0.0 | GCK, INSR, ENPP1, IRS1, IL6, PPARG |
negative regulation of hormone secretion (GO:0046888) | - | 5.41 | 0.005 | SLC2A4, GCK, ABCC8, IL6, IRS1, KCNJ11 |
positive regulation of fatty acid metabolic process (GO:0045923) | - | 6.23 | 0.0 | AKT2, PPARG, IRS2, IRS1 |
regulation of cellular localization (GO:0060341) | - | 3.03 | 0.0 | PPP1R3A, PTPN1, CAPN10, MTNR1B, PDX1, HNF1A, INSR, RETN, SLC2A2, GCGR, AKT2, IRS2, ABCC8, SLC30A8, NEUROD1, GCK, SLC2A4, KCNJ11, IRS1, IL6, HMGA1, TCF7L2, PPARG, HNF4A |
cell projection organization (GO:0030030) | NEW | 3.14 | 0.02 | AKT2, PDX1, INSR, GCK, PTPN1, MAPK8IP1, KCNJ11, IRS1, IL6, TCF7L2, RETN, IRS2, HNF1B, PPARG |
homeostatic process (GO:0042592) | - | 2.61 | 0.0 | SLC30A8, SLC2A4, NEUROD1, INSR, GCK, PDX1, ENPP1, TCF7L2, IRS1, IL6, KCNJ11, WFS1, LIPC, IRS2, HNF1A, GCGR, PPARG, MTNR1B, HNF4A |
glucose homeostasis (GO:0042593) | - | 4.6 | 0.0 | SLC2A4, NEUROD1, INSR, GCK, PDX1, TCF7L2, IRS1, IL6, KCNJ11, WFS1, IRS2, HNF1A, GCGR, PPARG, MTNR1B, HNF4A |
regulation of glucose transport (GO:0010827) | - | 5.12 | 0.0 | AKT2, INSR, GCK, ENPP1, IRS1, CAPN10, IRS2, PPARG |
response to starvation (GO:0042594) | - | 4.69 | 0.013 | GCK, INSR, IRS1, TCF7L2, RETN, IRS2, GCGR |
fat cell differentiation (GO:0045444) | - | 5.02 | 0.001 | AKT2, SLC2A4, TCF7L2, IRS1, IL6, RETN, IRS2, GCGR, PPARG |
cell death (GO:0008219) | - | 3.05 | 0.003 | AKT2, NEUROD1, MAPK8IP1, INSR, PTPN1, MTNR1B, IL6, IRS1, CAPN10, GCGR, HMGA1, RETN, IRS2, HNF1A, HNF1B, PPARG, TCF7L2 |
generation of precursor metabolites and energy (GO:0006091) | - | 4.07 | 0.0 | AKT2, SLC2A4, NEUROD1, INSR, GCK, PDX1, ENPP1, PPP1R3A, IRS1, IL6, KCNJ11, SLC2A2, ABCC8, GCGR, PPARG, TCF7L2 |
acylglycerol homeostasis (GO:0055090) | - | 6.33 | 0.008 | PPARG, HNF4A, LIPC, RETN |
detection of hexose stimulus (GO:0009732) | - | 8.63 | 0.015 | PDX1, GCK |
detection of carbohydrate stimulus (GO:0009730) | - | 8.63 | 0.015 | PDX1, GCK |
response to lipid (GO:0033993) | - | 3.11 | 0.0 | AKT2, SLC2A4, NEUROD1, ABCC8, INSR, PTPN1, PDX1, IRS2, MAPK8IP1, PPP1R3A, IRS1, IL6, KCNJ11, LIPC, TCF7L2, HNF1A, GCGR, PPARG, HNF4A, RETN |
regulation of cellular macromolecule biosynthetic process (GO:2000112) | - | 1.46 | 0.006 | PAX4, NEUROD1, INSR, GCK, IGF2BP2, PDX1, ENPP1, AKT2, IRS1, WFS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, MAPK8IP1, PPARG, TCF7L2, HNF4A |
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) | - | 2.6 | 0.0 | PTPN1, ENPP1, PAX4, TCF7L2, MTNR1B, PDX1, HNF1A, GCK, RETN, GCGR, IGF2BP2, AKT2, MAPK8IP1, HNF1B, NEUROD1, INSR, SLC2A4, IRS1, IL6, HMGA1, IRS2, PPARG, HNF4A |
positive regulation of glucose transport (GO:0010828) | - | 5.99 | 0.0 | AKT2, INSR, IRS1, CAPN10, IRS2, PPARG |
regulation of programmed cell death (GO:0043067) | - | 2.49 | 0.016 | PAX4, NEUROD1, MAPK8IP1, PDX1, CAPN10, IL6, WFS1, IRS2, HNF1B, PPARG, TCF7L2 |
negative regulation of apoptotic process (GO:0043066) | - | 3.04 | 0.0 | PAX4, NEUROD1, MAPK8IP1, INSR, PTPN1, PDX1, TCF7L2, IRS1, WFS1, IL6, HMGA1, LIPC, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
negative regulation of programmed cell death (GO:0043069) | - | 3.02 | 0.0 | PAX4, NEUROD1, MAPK8IP1, INSR, PTPN1, PDX1, TCF7L2, IRS1, WFS1, IL6, HMGA1, LIPC, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
regulation of fatty acid metabolic process (GO:0019217) | - | 5.25 | 0.013 | AKT2, SLC2A4, IRS1, IRS2, PPARG, HNF4A |
regulation of lipid metabolic process (GO:0019216) | - | 4.08 | 0.0 | SLC2A4, AKT2, IRS1, IL6, LIPC, IRS2, GCGR, PPARG, TCF7L2, HNF4A, RETN |
regulation of steroid metabolic process (GO:0019218) | NEW | 5.42 | 0.001 | PTPN1, IRS1, IL6, RETN, GCGR, PPARG, HNF4A |
single-organism developmental process (GO:0044767) | - | 1.49 | 0.018 | AKT2, SLC2A4, NEUROD1, GCK, GPD2, SLC2A2, PDX1, PAX4, IRS1, WFS1, IL6, TCF7L2, INSR, HMGA1, RETN, IRS2, HNF1B, PPARG, HNF4A |
single-organism transport (GO:0044765) | - | 2.18 | 0.0 | SLC30A8, AKT2, NEUROD1, ABCC8, GCK, PDX1, ENPP1, KCNJ11, WFS1, IL6, GCGR, SLC2A4, SLC2A2, HNF1A, HNF1B, PPARG, TCF7L2, LIPC |
single-organism cellular process (GO:0044763) | - | 0.65 | 0.021 | PTPN1, ENPP1, PAX4, KCNJ11, CAPN10, MTNR1B, PDX1, HNF1A, ABCC8, INSR, PPP1R3A, RETN, WFS1, SLC2A2, GCGR, AKT2, GPD2, HNF1B, SLC30A8, NEUROD1, GCK, SLC2A4, TCF7L2, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A |
embryonic epithelial tube formation (GO:0001838) | NEW | 6.4 | 0.008 | IRS1, HNF1B, TCF7L2, MAPK8IP1 |
cellular response to oxygen-containing compound (GO:1901701) | - | 3.22 | 0.0 | AKT2, SLC2A4, NEUROD1, GCK, INSR, PTPN1, PDX1, ENPP1, IL6, IRS1, KCNJ11, CAPN10, RETN, IRS2, ABCC8, GCGR, MAPK8IP1, PPARG, TCF7L2 |
positive regulation of locomotion (GO:0040017) | - | 3.71 | 0.022 | AKT2, INSR, PTPN1, PDX1, TCF7L2, IRS1, IL6, RETN, IRS2, GCGR, PPARG |
anatomical structure development (GO:0048856) | - | 1.58 | 0.005 | GPD2, PAX4, NEUROD1, IRS2, GCK, PDX1, ENPP1, TCF7L2, IRS1, IL6, INSR, WFS1, SLC2A2, HNF1B, PPARG, HNF4A |
regulation of lipid catabolic process (GO:0050994) | - | 5.8 | 0.003 | IRS2, IL6, PPARG, AKT2, IRS1 |
hormone transport (GO:0009914) | - | 5.33 | 0.0 | SLC30A8, PDX1, HNF1A, PTPN1, IL6, NEUROD1, HNF1B, PPARG |
regulation of organ morphogenesis (GO:2000027) | NEW | 4.22 | 0.009 | PDX1, PPARG, TCF7L2, IRS1, IL6, HNF1B, KCNJ11, HNF4A |
negative regulation of cellular process (GO:0048523) | - | 1.41 | 0.001 | AKT2, WFS1, NEUROD1, IRS2, GCK, IGF2BP2, PTPN1, PDX1, ENPP1, IL6, IRS1, KCNJ11, HMGA1, TCF7L2, PAX4, HNF1B, MAPK8IP1, PPARG, HNF4A |
positive regulation of cellular process (GO:0048522) | - | 1.3 | 0.001 | AKT2, SLC30A8, PAX4, NEUROD1, INSR, GCK, PDX1, MAPK8IP1, IL6, IRS1, WFS1, CAPN10, HMGA1, RETN, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
activation of protein kinase activity (GO:0032147) | - | 4.08 | 0.017 | NEUROD1, MAPK8IP1, INSR, IL6, IRS1, TCF7L2, IRS2, GCGR, PPARG |
behavior (GO:0007610) | NEW | 3.47 | 0.002 | SLC2A4, NEUROD1, INSR, PTPN1, PDX1, AKT2, IRS1, IL6, WFS1, RETN, IRS2, HNF1A, PPARG, TCF7L2 |
negative regulation of neuron apoptotic process (GO:0043524) | - | 4.82 | 0.016 | PTPN1, INSR, WFS1, IRS1, IL6, PPARG, LIPC |
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) | - | 3.54 | 0.007 | AKT2, NEUROD1, MAPK8IP1, INSR, PTPN1, TCF7L2, RETN, IL6, IRS1, IRS2, HNF1B, PPARG, GCGR |
nitrogen compound transport (GO:0071705) | - | 3.54 | 0.023 | SLC30A8, SLC2A4, NEUROD1, IGF2BP2, PTPN1, PDX1, IRS1, IL6, IRS2, HNF1A, HNF1B, PPARG |
positive regulation of cell cycle (GO:0045787) | NEW | 3.94 | 0.001 | INSR, TCF7L2, IRS1, IL6, IRS2, GCGR, PPARG, HNF4A |
positive regulation of glycogen metabolic process (GO:0070875) | - | 6.9 | 0.0 | AKT2, IRS1, IRS2, INSR, GCK |
regulation of neuron differentiation (GO:0045664) | - | 3.39 | 0.009 | SLC2A4, NEUROD1, MAPK8IP1, INSR, PTPN1, TCF7L2, IRS1, IL6, IRS2, MTNR1B, PPARG, GCGR, HNF4A |
negative regulation of molecular function (GO:0044092) | - | 2.74 | 0.002 | AKT2, PPP1R3A, NEUROD1, MAPK8IP1, INSR, PTPN1, TCF7L2, IRS1, WFS1, IL6, KCNJ11, HMGA1, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
negative regulation of transport (GO:0051051) | - | 3.6 | 0.004 | AKT2, SLC2A4, ABCC8, GCK, INSR, PTPN1, ENPP1, IL6, IRS1, KCNJ11, IRS2, PPARG |
positive regulation of transport (GO:0051050) | - | 2.9 | 0.0 | SLC30A8, SLC2A4, ABCC8, INSR, GCK, GPD2, PDX1, MAPK8IP1, TCF7L2, IRS1, AKT2, IL6, KCNJ11, CAPN10, WFS1, RETN, IRS2, GCGR, PPARG |
organic substance transport (GO:0071702) | - | 2.15 | 0.0 | AKT2, SLC30A8, SLC2A4, NEUROD1, GCK, PPARG, PDX1, IL6, TCF7L2, WFS1, SLC2A2, HNF1A, HNF1B, IGF2BP2, LIPC |
response to biotic stimulus (GO:0009607) | - | 3.09 | 0.011 | SLC2A4, HNF1A, INSR, GCK, PTPN1, IL6, IRS1, WFS1, KCNJ11, HMGA1, RETN, ABCC8, PPARG, LIPC |
response to organic substance (GO:0010033) | - | 2.2 | 0.0 | PTPN1, ENPP1, PAX4, KCNJ11, PDX1, GCK, RETN, WFS1, CAPN10, GCGR, AKT2, HNF1B, SLC30A8, NEUROD1, INSR, SLC2A4, TCF7L2, IRS1, IL6, IRS2, PPARG, HNF4A |
negative regulation of signaling (GO:0023057) | - | 2.65 | 0.0 | PTPN1, ENPP1, SLC2A4, KCNJ11, MTNR1B, PDX1, HNF1A, INSR, WFS1, GCGR, AKT2, MAPK8IP1, HNF1B, NEUROD1, TCF7L2, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A |
response to nutrient levels (GO:0031667) | - | 3.77 | 0.0 | AKT2, SLC2A4, INSR, GCK, PDX1, IL6, IRS1, TCF7L2, RETN, IRS2, GCGR, PPARG, HNF4A |
negative regulation of cellular response to insulin stimulus (GO:1900077) | - | 6.29 | 0.026 | PTPN1, ENPP1, IRS1, INSR |
cellular response to carbohydrate stimulus (GO:0071322) | - | 5.52 | 0.024 | IL6, NEUROD1, PTPN1, IRS2, KCNJ11 |
positive regulation of fatty acid oxidation (GO:0046321) | - | 7.09 | 0.0 | AKT2, PPARG, IRS2, IRS1 |
regulation of fatty acid oxidation (GO:0046320) | - | 6.4 | 0.002 | AKT2, PPARG, IRS2, IRS1 |
negative regulation of gene expression (GO:0010629) | - | 2.48 | 0.004 | AKT2, SLC2A4, NEUROD1, MAPK8IP1, GCK, PTPN1, MTNR1B, PDX1, PAX4, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
regulation of glucose import (GO:0046324) | - | 5.63 | 0.0 | AKT2, INSR, ENPP1, IRS1, CAPN10, IRS2, PPARG |
positive regulation of glucose import (GO:0046326) | - | 6.09 | 0.0 | AKT2, INSR, IRS1, CAPN10, IRS2, PPARG |
cellular polysaccharide metabolic process (GO:0044264) | - | 5.41 | 0.019 | AKT2, TCF7L2, PPP1R3A, GCK |
cellular carbohydrate metabolic process (GO:0044262) | - | 4.74 | 0.02 | AKT2, GPD2, GCK, PPP1R3A, IRS1, TCF7L2, PPARG |
organ morphogenesis (GO:0009887) | - | 3.55 | 0.0 | AKT2, PAX4, NEUROD1, INSR, PTPN1, PDX1, TCF7L2, IL6, HMGA1, MAPK8IP1, HNF1A, HNF1B, PPARG, GCGR |
hexose metabolic process (GO:0019318) | - | 4.64 | 0.0 | PDX1, HNF1A, GPD2, GCK, AKT2, IRS1, KCNJ11, IRS2, GCGR, PPARG, TCF7L2, HNF4A |
regulation of insulin secretion (GO:0050796) | - | 4.57 | 0.0 | SLC30A8, PDX1, NEUROD1, IRS2, GCK, INSR, SLC2A4, IRS1, IL6, KCNJ11, CAPN10, GCGR, SLC2A2, ABCC8, MTNR1B, PPARG, TCF7L2, HNF4A |
regulation of behavior (GO:0050795) | - | 5.55 | 0.031 | PTPN1, INSR, TCF7L2, IRS1, IL6, RETN, GCGR, PPARG |
negative regulation of neuron death (GO:1901215) | - | 4.57 | 0.038 | PTPN1, INSR, WFS1, IRS1, IL6, PPARG, LIPC |
regulation of metal ion transport (GO:0010959) | - | 3.94 | 0.002 | GPD2, AKT2, SLC2A2, GCK, PTPN1, IL6, INSR, WFS1, IRS2, PPARG |
energy derivation by oxidation of organic compounds (GO:0015980) | - | 4.93 | 0.0 | AKT2, SLC2A4, ABCC8, GCK, PPP1R3A, TCF7L2, IRS1, IL6, KCNJ11, SLC2A2, GCGR, PPARG |
regulation of lipid transport (GO:0032368) | - | 5.21 | 0.013 | AKT2, INSR, RETN, IL6, IRS2, PPARG |
response to stimulus (GO:0050896) | - | 1.22 | 0.033 | PTPN1, ENPP1, PAX4, CAPN10, MTNR1B, PDX1, INSR, RETN, WFS1, GCGR, AKT2, ABCC8, HNF1B, SLC30A8, NEUROD1, GCK, SLC2A4, KCNJ11, IRS1, IL6, HMGA1, IRS2, PPARG, TCF7L2, HNF4A |
cognition (GO:0050890) | NEW | 4.2 | 0.003 | AKT2, SLC2A4, INSR, PTPN1, PDX1, IRS1, IL6, RETN, IRS2, PPARG |
regulation of transferase activity (GO:0051338) | - | 2.88 | 0.001 | PDX1, NEUROD1, INSR, GCK, PTPN1, MAPK8IP1, TCF7L2, IRS1, IL6, WFS1, RETN, IRS2, ABCC8, MTNR1B, PPARG, GCGR, HNF4A |
regulation of nervous system development (GO:0051960) | - | 3.1 | 0.001 | SLC2A4, NEUROD1, MAPK8IP1, INSR, PTPN1, TCF7L2, IRS1, IL6, HMGA1, RETN, IRS2, HNF1A, MTNR1B, PPARG, GCGR, HNF4A |
regulation of cell motility (GO:2000145) | - | 3.16 | 0.033 | AKT2, PDX1, INSR, PTPN1, TCF7L2, IRS1, IL6, RETN, IRS2, HNF1B, PPARG, GCGR, HNF4A |
positive regulation of cell motility (GO:2000147) | - | 3.74 | 0.016 | AKT2, PDX1, INSR, PTPN1, TCF7L2, RETN, IL6, IRS1, IRS2, GCGR, PPARG |
regulation of carbohydrate metabolic process (GO:0006109) | - | 4.57 | 0.0 | SLC2A4, NEUROD1, GCK, INSR, ENPP1, AKT2, IRS1, IL6, IRS2, GCGR, PPARG, TCF7L2, HNF4A |
negative regulation of multicellular organismal process (GO:0051241) | - | 2.84 | 0.01 | NEUROD1, INSR, ENPP1, TCF7L2, RETN, IL6, IRS1, MAPK8IP1, HNF1A, HNF1B, PPARG, GCGR |
positive regulation of protein metabolic process (GO:0051247) | - | 2.43 | 0.001 | AKT2, PDX1, NEUROD1, MAPK8IP1, INSR, PTPN1, TCF7L2, IRS1, WFS1, IL6, KCNJ11, HMGA1, RETN, IRS2, HNF1A, MTNR1B, PPARG, GCGR, HNF4A |
regulation of MAP kinase activity (GO:0043405) | - | 3.95 | 0.045 | PTPN1, NEUROD1, INSR, TCF7L2, IRS1, IL6, MAPK8IP1, GCGR, HNF4A |
cellular response to chemical stimulus (GO:0070887) | - | 2.57 | 0.0 | AKT2, SLC2A4, NEUROD1, INSR, GCK, PTPN1, ENPP1, CAPN10, IRS1, IL6, KCNJ11, WFS1, IRS2, GCGR, PPARG, HNF4A |
digestive tract development (GO:0048565) | NEW | 5.49 | 0.041 | NEUROD1, IL6, PPARG, PDX1, IRS1 |
regulation of polysaccharide biosynthetic process (GO:0032885) | - | 6.09 | 0.0 | AKT2, GCK, INSR, ENPP1, IRS1, IRS2 |
regulation of polysaccharide metabolic process (GO:0032881) | - | 5.97 | 0.0 | AKT2, GCK, INSR, ENPP1, IRS1, IRS2, GCGR |
regulation of MAPK cascade (GO:0043408) | - | 3.22 | 0.001 | PDX1, NEUROD1, MAPK8IP1, INSR, PTPN1, TCF7L2, RETN, IL6, IRS1, IRS2, HNF1B, PPARG, GCGR, HNF4A |
regulation of neurogenesis (GO:0050767) | - | 3.21 | 0.0 | SLC2A4, NEUROD1, MAPK8IP1, INSR, PTPN1, TCF7L2, RETN, IL6, HMGA1, IRS1, IRS2, HNF1A, MTNR1B, PPARG, GCGR, HNF4A |
negative regulation of protein metabolic process (GO:0051248) | - | 2.82 | 0.002 | PDX1, NEUROD1, MAPK8IP1, INSR, IGF2BP2, PTPN1, ENPP1, TCF7L2, IRS1, IL6, IRS2, HNF1A, GCGR, PPARG, HNF4A |
cellular response to peptide hormone stimulus (GO:0071375) | - | 4.63 | 0.0 | AKT2, SLC2A4, INSR, GCK, PTPN1, ENPP1, IL6, IRS1, TCF7L2, CAPN10, RETN, IRS2, GCGR, PPARG |
positive regulation of phosphorus metabolic process (GO:0010562) | - | 2.78 | 0.0 | AKT2, PDX1, NEUROD1, INSR, GCK, PTPN1, MAPK8IP1, IL6, IRS1, WFS1, TCF7L2, HMGA1, RETN, IRS2, MTNR1B, PPARG, GCGR, HNF4A |
positive regulation of kinase activity (GO:0033674) | - | 3.54 | 0.0 | PDX1, NEUROD1, INSR, GCK, PTPN1, MAPK8IP1, IL6, IRS1, TCF7L2, WFS1, RETN, IRS2, GCGR, PPARG, MTNR1B, HNF4A |
regulation of cellular ketone metabolic process (GO:0010565) | - | 4.67 | 0.0 | SLC2A4, GCK, AKT2, IRS1, IL6, IRS2, PPARG, TCF7L2, HNF4A |
response to oxygen-containing compound (GO:1901700) | - | 2.57 | 0.0 | AKT2, SLC30A8, SLC2A4, NEUROD1, INSR, GCK, PTPN1, PDX1, IRS2, ENPP1, KCNJ11, IRS1, IL6, CAPN10, RETN, TCF7L2, PAX4, HNF1B, PPARG, GCGR, HNF4A |
reproductive structure development (GO:0048608) | - | 4.08 | 0.014 | AKT2, HNF1A, INSR, TCF7L2, IRS1, IL6, IRS2, HNF1B, PPARG, GCGR |
positive regulation of cellular component movement (GO:0051272) | - | 3.71 | 0.002 | AKT2, PDX1, INSR, PTPN1, TCF7L2, RETN, IL6, IRS1, IRS2, GCGR, PPARG |
regulation of carbohydrate catabolic process (GO:0043470) | - | 5.97 | 0.044 | IRS2, PPARG, GCK, INSR |
regulation of cellular carbohydrate catabolic process (GO:0043471) | NEW | 7.09 | 0.044 | IRS2, PPARG, INSR, GCK |
response to drug (GO:0042493) | - | 3.71 | 0.021 | SLC2A4, NEUROD1, INSR, PDX1, IL6, RETN, KCNJ11, IRS1, PAX4, HNF1A, PPARG |
system development (GO:0048731) | - | 2.92 | 0.001 | PDX1, NEUROD1, ABCC8, INSR, PTPN1, MAPK8IP1, KCNJ11, IRS1, IL6, TCF7L2, HMGA1, RETN, IRS2, HNF1A, HNF1B, PPARG, GCGR |
single organismal cell-cell adhesion (GO:0016337) | NEW | 3.69 | 0.029 | SLC2A4, HNF1A, INSR, PTPN1, TCF7L2, IRS1, IL6, HNF1B, PPARG |
regulation of lipid biosynthetic process (GO:0046890) | NEW | 4.87 | 0.0 | SLC2A4, PTPN1, TCF7L2, IRS1, IL6, RETN, GCGR, PPARG, HNF4A |
positive regulation of lipid catabolic process (GO:0050996) | - | 6.51 | 0.004 | AKT2, PPARG, IRS2, IRS1 |
actin cytoskeleton reorganization (GO:0031532) | - | 5.84 | 0.001 | IL6, CAPN10, PPARG, PTPN1, IRS1 |
peptide hormone secretion (GO:0030072) | - | 5.69 | 0.0 | SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B, PPARG |
protein import (GO:0017038) | NEW | 4.85 | 0.018 | NEUROD1, IRS1, TCF7L2, IRS2, GCGR, PPARG |
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) | - | 2.55 | 0.0 | AKT2, SLC2A4, NEUROD1, INSR, GCK, PTPN1, MTNR1B, PDX1, MAPK8IP1, PAX4, IRS1, IL6, GCGR, HMGA1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
positive regulation of phosphate metabolic process (GO:0045937) | - | 2.78 | 0.0 | AKT2, PDX1, NEUROD1, INSR, GCK, PTPN1, MAPK8IP1, IL6, IRS1, WFS1, TCF7L2, HMGA1, RETN, IRS2, MTNR1B, PPARG, GCGR, HNF4A |
regulation of insulin receptor signaling pathway (GO:0046626) | - | 5.97 | 0.0 | IRS1, IL6, ENPP1, PTPN1, INSR |
negative regulation of insulin receptor signaling pathway (GO:0046627) | - | 6.36 | 0.003 | PTPN1, ENPP1, IRS1, INSR |
metal ion homeostasis (GO:0055065) | - | 3.61 | 0.007 | SLC30A8, PTPN1, INSR, GCK, WFS1, RETN, IL6, IRS2, HNF1B, PPARG, GCGR |
cell-cell signaling (GO:0007267) | NEW | 3.35 | 0.001 | AKT2, SLC2A4, NEUROD1, ABCC8, INSR, PTPN1, PDX1, IL6, IRS1, KCNJ11, GCGR, IRS2, HNF1A, MTNR1B, PPARG, TCF7L2 |
response to chemical (GO:0042221) | - | 1.98 | 0.0 | PTPN1, ENPP1, WFS1, CAPN10, PDX1, INSR, RETN, GCGR, AKT2, IRS2, HNF1B, PAX4, SLC30A8, NEUROD1, GCK, SLC2A4, KCNJ11, IRS1, IL6, TCF7L2, PPARG, HNF4A |
tube development (GO:0035295) | - | 4.41 | 0.0 | AKT2, NEUROD1, PTPN1, PDX1, TCF7L2, IRS1, IL6, MAPK8IP1, HNF1A, HNF1B, PPARG, HNF4A |
response to hexose (GO:0009746) | - | 4.82 | 0.0 | SLC30A8, PDX1, NEUROD1, GCK, TCF7L2, IL6, IRS2, HNF1A, KCNJ11, PPARG, HNF1B, HNF4A |
response to abiotic stimulus (GO:0009628) | - | 2.8 | 0.003 | SLC2A4, NEUROD1, INSR, GPD2, PDX1, TCF7L2, IRS1, IL6, KCNJ11, HMGA1, LIPC, MAPK8IP1, ABCC8, HNF1A, GCGR, PPARG, HNF4A, RETN |
carbohydrate metabolic process (GO:0005975) | - | 3.26 | 0.0 | AKT2, PPP1R3A, HNF1A, INSR, SLC2A4, GCK, GPD2, PDX1, IRS1, IL6, KCNJ11, SLC2A2, ABCC8, IRS2, GCGR, PPARG, TCF7L2, HNF4A |
response to carbohydrate (GO:0009743) | - | 4.62 | 0.0 | SLC30A8, PDX1, NEUROD1, INSR, GCK, PTPN1, TCF7L2, IRS1, IL6, KCNJ11, IRS2, ABCC8, HNF1A, HNF1B, PPARG, HNF4A |
glycogen metabolic process (GO:0005977) | - | 5.67 | 0.005 | AKT2, TCF7L2, PPP1R3A, GCK |
polysaccharide metabolic process (GO:0005976) | - | 5.32 | 0.026 | AKT2, TCF7L2, PPP1R3A, GCK |
regulation of fatty acid beta-oxidation (GO:0031998) | - | 6.96 | 0.0 | AKT2, PPARG, IRS2, IRS1 |
regulation of peptide secretion (GO:0002791) | - | 4.38 | 0.0 | SLC30A8, SLC2A4, NEUROD1, IRS2, GCK, PDX1, CAPN10, IRS1, IL6, KCNJ11, INSR, SLC2A2, ABCC8, MTNR1B, PPARG, GCGR, HNF4A, TCF7L2 |
positive regulation of peptide secretion (GO:0002793) | - | 5.22 | 0.0 | SLC30A8, PDX1, IRS2, GCK, TCF7L2, IL6, CAPN10, PPARG |
response to glucose (GO:0009749) | - | 4.86 | 0.0 | SLC30A8, PDX1, NEUROD1, GCK, KCNJ11, IL6, TCF7L2, IRS2, HNF1A, HNF1B, PPARG, HNF4A |
locomotion (GO:0040011) | NEW | 2.91 | 0.001 | AKT2, NEUROD1, ABCC8, GCK, PTPN1, PDX1, TCF7L2, RETN, IL6, INSR, HMGA1, IRS1, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
regulation of peptide transport (GO:0090087) | - | 4.37 | 0.0 | SLC30A8, PDX1, NEUROD1, IRS2, GCK, INSR, SLC2A4, IRS1, IL6, KCNJ11, CAPN10, GCGR, SLC2A2, ABCC8, MTNR1B, PPARG, TCF7L2, HNF4A |
positive regulation of insulin secretion (GO:0032024) | - | 5.57 | 0.0 | SLC30A8, PDX1, IRS2, GCK, TCF7L2, IL6, CAPN10, PPARG |
negative regulation of response to stimulus (GO:0048585) | - | 2.52 | 0.018 | PDX1, NEUROD1, ENPP1, PTPN1, RETN, TCF7L2, WFS1, IRS1, MAPK8IP1, PPARG |
regulation of response to stimulus (GO:0048583) | - | 1.54 | 0.009 | AKT2, NEUROD1, MAPK8IP1, INSR, PTPN1, PDX1, ENPP1, TCF7L2, IRS1, WFS1, IL6, HMGA1, RETN, IRS2, HNF1B, PPARG, HNF4A |
regulation of homeostatic process (GO:0032844) | - | 3.65 | 0.0 | SLC30A8, SLC2A4, NEUROD1, IRS2, INSR, PTPN1, KCNJ11, IRS1, IL6, GCGR, SLC2A2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
regulation of glucan biosynthetic process (GO:0010962) | - | 6.33 | 0.0 | AKT2, GCK, INSR, ENPP1, IRS1, IRS2 |
negative regulation of signal transduction (GO:0009968) | - | 2.75 | 0.0 | AKT2, SLC2A4, NEUROD1, MAPK8IP1, INSR, PTPN1, MTNR1B, PDX1, ENPP1, KCNJ11, IRS1, IL6, GCGR, WFS1, LIPC, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
kidney development (GO:0001822) | - | 4.79 | 0.003 | WFS1, NEUROD1, ABCC8, TCF7L2, IL6, MAPK8IP1, HNF1B, PPARG |
hormone secretion (GO:0046879) | - | 5.48 | 0.0 | SLC30A8, PDX1, HNF1A, PTPN1, IL6, NEUROD1, HNF1B, PPARG |
cellular glucan metabolic process (GO:0006073) | - | 5.65 | 0.005 | AKT2, TCF7L2, PPP1R3A, GCK |
negative regulation of cell development (GO:0010721) | NEW | 4.02 | 0.013 | PTPN1, HNF1A, IL6, IRS1, TCF7L2, HMGA1, IRS2, PPARG |
positive regulation of biological process (GO:0048518) | - | 1.2 | 0.003 | AKT2, SLC30A8, WFS1, NEUROD1, INSR, GCK, PDX1, MAPK8IP1, IL6, RETN, KCNJ11, CAPN10, HMGA1, IRS1, IRS2, PAX4, HNF1B, HNF1A, PPARG, TCF7L2, HNF4A |
negative regulation of biological process (GO:0048519) | - | 1.33 | 0.001 | AKT2, WFS1, NEUROD1, IRS2, GCK, IGF2BP2, PTPN1, PDX1, ENPP1, IL6, IRS1, KCNJ11, HMGA1, RETN, TCF7L2, PAX4, HNF1B, MAPK8IP1, PPARG, HNF4A |
developmental process involved in reproduction (GO:0003006) | - | 3.36 | 0.016 | SLC2A4, HNF1A, INSR, PTPN1, AKT2, IRS1, IL6, GCGR, HMGA1, IRS2, HNF1B, PPARG, TCF7L2, HNF4A |
regionalization (GO:0003002) | - | 4.24 | 0.007 | PDX1, NEUROD1, TCF7L2, IRS1, IL6, MAPK8IP1, HNF1A, HNF1B, PPARG, GCGR |
response to peptide hormone (GO:0043434) | - | 4.06 | 0.0 | SLC2A4, INSR, GCK, PTPN1, ENPP1, AKT2, RETN, IL6, CAPN10, IRS1, IRS2, GCGR, PPARG, TCF7L2 |
regulation of glycogen metabolic process (GO:0070873) | - | 6.17 | 0.0 | AKT2, GCK, INSR, ENPP1, IRS1, IRS2, GCGR |
negative regulation of sequence-specific DNA binding transcription factor activity (GO:0043433) | - | 4.82 | 0.002 | WFS1, NEUROD1, TCF7L2, IRS1, IL6, HMGA1, MAPK8IP1, HNF1B |
oxidation-reduction process (GO:0055114) | - | 2.91 | 0.002 | GPD2, SLC2A4, ABCC8, INSR, GCK, SLC2A2, PTPN1, PPP1R3A, IRS1, AKT2, IL6, KCNJ11, HMGA1, TCF7L2, GCGR, PPARG, HNF4A |
single organism signaling (GO:0044700) | NEW | 3.25 | 0.001 | AKT2, SLC2A4, NEUROD1, ABCC8, INSR, PTPN1, PDX1, IL6, IRS1, KCNJ11, GCGR, IRS2, HNF1A, MTNR1B, PPARG, TCF7L2 |
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) | - | 4.62 | 0.049 | PTPN1, RETN, IL6, HMGA1, IRS1, MAPK8IP1, PPARG |
single-organism behavior (GO:0044708) | NEW | 3.79 | 0.004 | AKT2, SLC2A4, INSR, PTPN1, PDX1, TCF7L2, IRS1, IL6, WFS1, RETN, IRS2, PPARG |
response to organonitrogen compound (GO:0010243) | - | 3.2 | 0.0 | AKT2, SLC2A4, GCK, ABCC8, PTPN1, PDX1, ENPP1, PAX4, IRS1, IL6, KCNJ11, INSR, RETN, IRS2, CAPN10, GCGR, MAPK8IP1, PPARG, TCF7L2, HNF4A |
JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397) | NEW | 7.02 | 0.014 | PTPN1, IRS2, IRS1 |
carbohydrate biosynthetic process (GO:0016051) | - | 4.93 | 0.041 | AKT2, GCK, GPD2, IRS1, IL6, PPARG |
monosaccharide metabolic process (GO:0005996) | - | 4.57 | 0.0 | AKT2, HNF1A, GPD2, GCK, PDX1, TCF7L2, IRS1, KCNJ11, IRS2, GCGR, PPARG, HNF4A |
regulation of anatomical structure morphogenesis (GO:0022603) | - | 2.79 | 0.001 | SLC2A4, NEUROD1, ABCC8, INSR, PTPN1, PDX1, IRS2, MAPK8IP1, KCNJ11, IRS1, IL6, TCF7L2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
regulation of apoptotic process (GO:0042981) | - | 2.5 | 0.014 | PAX4, NEUROD1, MAPK8IP1, PDX1, CAPN10, IL6, WFS1, IRS2, HNF1B, PPARG, TCF7L2 |
regulation of gliogenesis (GO:0014013) | NEW | 5.21 | 0.009 | HNF1A, TCF7L2, RETN, IL6, IRS2, PPARG |
regulation of kinase activity (GO:0043549) | - | 3.07 | 0.0 | PDX1, NEUROD1, INSR, GCK, PTPN1, MAPK8IP1, IL6, IRS1, TCF7L2, WFS1, RETN, IRS2, ABCC8, GCGR, PPARG, MTNR1B, HNF4A |
positive regulation of glycogen biosynthetic process (GO:0045725) | - | 7.02 | 0.0 | IRS1, AKT2, IRS2, INSR, GCK |
cell migration (GO:0016477) | NEW | 3.12 | 0.002 | AKT2, NEUROD1, INSR, PTPN1, PDX1, TCF7L2, IRS1, IL6, HMGA1, RETN, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
anatomical structure formation involved in morphogenesis (GO:0048646) | - | 3.01 | 0.001 | AKT2, PDX1, HNF1A, ABCC8, INSR, SLC2A2, PTPN1, TCF7L2, IRS1, IL6, GCGR, HMGA1, MAPK8IP1, KCNJ11, PPARG, HNF1B, HNF4A |
regulation of tube size (GO:0035150) | NEW | 4.79 | 0.047 | IL6, TCF7L2, PPARG, IRS1, ABCC8 |
cation transport (GO:0006812) | - | 3.11 | 0.013 | SLC30A8, SLC2A4, HNF1A, INSR, GCK, PTPN1, KCNJ11, IRS1, IL6, IRS2, ABCC8, HNF1B, PPARG, GCGR |
ion transport (GO:0006811) | - | 2.66 | 0.001 | SLC30A8, SLC2A4, HNF1A, IRS2, GCK, GPD2, PTPN1, ENPP1, IL6, IRS1, KCNJ11, INSR, SLC2A2, ABCC8, HNF1B, PPARG, GCGR, HNF4A |
transport (GO:0006810) | - | 1.51 | 0.001 | AKT2, SLC30A8, SLC2A4, NEUROD1, ABCC8, GCK, PPARG, PDX1, ENPP1, TCF7L2, IL6, KCNJ11, WFS1, SLC2A2, HNF1A, HNF1B, MAPK8IP1, IGF2BP2, GCGR, LIPC |
programmed cell death (GO:0012501) | - | 3.1 | 0.03 | AKT2, NEUROD1, MAPK8IP1, INSR, PTPN1, TCF7L2, RETN, IL6, HMGA1, CAPN10, HNF1A, HNF1B, PPARG, GCGR |
regulation of steroid biosynthetic process (GO:0050810) | NEW | 5.84 | 0.04 | PTPN1, PPARG, IRS1, HNF4A, RETN |
cellular glucose homeostasis (GO:0001678) | - | 5.48 | 0.003 | KCNJ11, NEUROD1, IRS2, GCK |
negative regulation of intracellular signal transduction (GO:1902532) | - | 3.63 | 0.0 | PDX1, NEUROD1, MAPK8IP1, PTPN1, TCF7L2, IRS1, IL6, WFS1, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
positive regulation of cell differentiation (GO:0045597) | - | 3.01 | 0.0 | AKT2, PAX4, NEUROD1, MAPK8IP1, INSR, PTPN1, PDX1, IL6, IRS1, TCF7L2, HMGA1, RETN, IRS2, HNF1A, GCGR, PPARG, HNF4A |
secretion (GO:0046903) | - | 3.38 | 0.047 | AKT2, SLC30A8, SLC2A4, NEUROD1, MAPK8IP1, PTPN1, PDX1, TCF7L2, IRS1, IL6, GCGR, IRS2, HNF1A, HNF1B, PPARG, MTNR1B |
regulation of response to stress (GO:0080134) | - | 2.53 | 0.0 | AKT2, PDX1, NEUROD1, GPD2, INSR, PTPN1, MAPK8IP1, IL6, IRS1, WFS1, KCNJ11, GCGR, HMGA1, RETN, IRS2, SLC2A4, PPARG, TCF7L2, HNF4A |
positive regulation of protein modification process (GO:0031401) | - | 2.7 | 0.0 | AKT2, NEUROD1, MAPK8IP1, INSR, PTPN1, PDX1, IL6, IRS1, WFS1, KCNJ11, GCGR, HMGA1, RETN, IRS2, HNF1A, MTNR1B, PPARG, TCF7L2, HNF4A |
organic hydroxy compound metabolic process (GO:1901615) | - | 3.84 | 0.007 | SLC2A4, NEUROD1, GPD2, PTPN1, AKT2, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A |
endocrine pancreas development (GO:0031018) | - | 6.36 | 0.0 | PAX4, NEUROD1, GCK, PDX1, TCF7L2, IL6, SLC2A2, HNF1A, HNF1B, PPARG, HNF4A |
peptide transport (GO:0015833) | - | 5.44 | 0.001 | SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B, PPARG |
response to endogenous stimulus (GO:0009719) | - | 2.79 | 0.0 | AKT2, SLC2A4, INSR, GCK, PTPN1, PDX1, ENPP1, CAPN10, RETN, IL6, KCNJ11, IRS1, IRS2, PAX4, GCGR, PPARG, HNF4A |
cell fate specification (GO:0001708) | NEW | 5.57 | 0.008 | PDX1, HNF1A, TCF7L2, NEUROD1, HNF1B, PPARG |
positive regulation of cellular protein metabolic process (GO:0032270) | - | 2.49 | 0.0 | AKT2, NEUROD1, MAPK8IP1, INSR, PTPN1, PDX1, IL6, IRS1, WFS1, KCNJ11, GCGR, HMGA1, RETN, IRS2, HNF1A, MTNR1B, PPARG, TCF7L2, HNF4A |
developmental process (GO:0032502) | - | 1.36 | 0.003 | AKT2, PAX4, NEUROD1, IRS2, GCK, GPD2, PPARG, PDX1, ENPP1, WFS1, RETN, IL6, INSR, HMGA1, IRS1, SLC2A2, SLC2A4, IGF2BP2, HNF1B, HNF4A, TCF7L2 |
positive regulation of cellular catabolic process (GO:0031331) | - | 4.15 | 0.011 | IRS1, AKT2, IRS2, INSR, GCK |
cellular response to hormone stimulus (GO:0032870) | - | 3.99 | 0.0 | AKT2, SLC2A4, INSR, GCK, PTPN1, PDX1, ENPP1, IL6, IRS1, TCF7L2, CAPN10, RETN, IRS2, GCGR, PPARG, HNF4A |
regulation of localization (GO:0032879) | - | 1.94 | 0.0 | SLC30A8, PDX1, NEUROD1, INSR, GCK, SLC2A2, PTPN1, ENPP1, TCF7L2, IRS1, AKT2, IL6, KCNJ11, WFS1, RETN, CAPN10, ABCC8, IRS2, MTNR1B, PPARG, HNF4A |
regulation of epithelial cell proliferation (GO:0050678) | NEW | 4.06 | 0.014 | PDX1, NEUROD1, TCF7L2, IL6, HMGA1, MAPK8IP1, HNF1B, PPARG, GCGR, HNF4A |
positive regulation of epithelial cell proliferation (GO:0050679) | NEW | 4.67 | 0.008 | PDX1, IL6, TCF7L2, HMGA1, MAPK8IP1, GCGR, PPARG, HNF4A |
cellular response to organic cyclic compound (GO:0071407) | - | 3.93 | 0.021 | AKT2, MAPK8IP1, ABCC8, KCNJ11, IRS1, IL6, TCF7L2, GCGR, PPARG, HNF4A |
negative regulation of RNA metabolic process (GO:0051253) | - | 2.66 | 0.0 | AKT2, SLC2A4, NEUROD1, MAPK8IP1, GCK, PTPN1, MTNR1B, PDX1, PAX4, IRS1, IL6, HMGA1, RETN, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
positive regulation of type B pancreatic cell apoptotic process (GO:2000676) | - | 8.34 | 0.015 | IL6, PDX1, CAPN10 |
negative regulation of type B pancreatic cell apoptotic process (GO:2000675) | - | 8.12 | 0.0 | PDX1, NEUROD1, WFS1, TCF7L2 |
regulation of glucose import in response to insulin stimulus (GO:2001273) | - | 6.9 | 0.008 | AKT2, PPARG, IRS1 |
positive regulation of glucose import in response to insulin stimulus (GO:2001275) | - | 7.24 | 0.049 | AKT2, IRS1 |
glucose metabolic process (GO:0006006) | - | 4.94 | 0.0 | AKT2, GPD2, GCK, PDX1, TCF7L2, IRS1, KCNJ11, IRS2, GCGR, PPARG, HNF4A |
negative regulation of protein modification process (GO:0031400) | - | 3.4 | 0.024 | PDX1, INSR, PTPN1, ENPP1, TCF7L2, IRS1, IL6, MAPK8IP1, GCGR, PPARG, HNF4A |
response to steroid hormone (GO:0048545) | - | 4.24 | 0.0 | PPP1R3A, HNF1A, ABCC8, INSR, PTPN1, PDX1, MAPK8IP1, TCF7L2, IRS1, IL6, KCNJ11, RETN, IRS2, PPARG, HNF4A |
regulation of cellular response to stress (GO:0080135) | - | 3.4 | 0.0 | PDX1, NEUROD1, MAPK8IP1, INSR, PTPN1, TCF7L2, IRS1, WFS1, IL6, HMGA1, IRS2, PPARG, HNF4A |
positive regulation of cell death (GO:0010942) | - | 3.32 | 0.002 | PDX1, NEUROD1, MAPK8IP1, PTPN1, TCF7L2, IRS1, IL6, HMGA1, RETN, CAPN10, HNF1A, GCGR, PPARG |
regulation of ion transport (GO:0043269) | - | 3.4 | 0.0 | AKT2, SLC2A4, NEUROD1, SLC2A2, GCK, GPD2, PTPN1, MAPK8IP1, IL6, IRS1, KCNJ11, INSR, WFS1, IRS2, ABCC8, PPARG |
pattern specification process (GO:0007389) | - | 3.79 | 0.042 | AKT2, NEUROD1, PDX1, TCF7L2, IRS1, IL6, MAPK8IP1, HNF1A, HNF1B, PPARG, GCGR |
regulation of generation of precursor metabolites and energy (GO:0043467) | - | 5.24 | 0.0 | AKT2, INSR, GCK, ENPP1, IRS1, IL6, IRS2, GCGR, PPARG |
glucose transport (GO:0015758) | - | 5.8 | 0.01 | IL6, HNF1A, SLC2A4, GCK, SLC2A2 |
cellular response to organic substance (GO:0071310) | - | 2.78 | 0.0 | AKT2, SLC2A4, NEUROD1, INSR, GCK, PTPN1, ENPP1, IL6, IRS1, KCNJ11, CAPN10, WFS1, IRS2, GCGR, PPARG, HNF4A |
tissue morphogenesis (GO:0048729) | - | 3.87 | 0.002 | AKT2, HNF1A, PTPN1, PDX1, TCF7L2, IRS1, IL6, HMGA1, MAPK8IP1, HNF1B, PPARG, HNF4A |
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) | - | 4.35 | 0.029 | PTPN1, INSR, RETN, IL6, HMGA1, IRS1, MAPK8IP1, PPARG |
positive regulation of cell migration (GO:0030335) | - | 3.77 | 0.014 | PDX1, INSR, PTPN1, TCF7L2, RETN, IL6, IRS1, IRS2, GCGR, PPARG |
regulation of cell migration (GO:0030334) | - | 3.23 | 0.019 | AKT2, INSR, PTPN1, PDX1, TCF7L2, IRS1, IL6, RETN, IRS2, HNF1B, PPARG, GCGR, HNF4A |
signal release (GO:0023061) | - | 4.65 | 0.0 | SLC30A8, PDX1, HNF1A, PTPN1, TCF7L2, IL6, NEUROD1, HNF1B, PPARG |
negative regulation of RNA biosynthetic process (GO:1902679) | - | 2.7 | 0.0 | AKT2, SLC2A4, NEUROD1, IRS2, GCK, PTPN1, PDX1, MAPK8IP1, PAX4, IRS1, IL6, HMGA1, RETN, TCF7L2, HNF1A, HNF1B, PPARG, MTNR1B, HNF4A |
localization (GO:0051179) | - | 1.4 | 0.001 | AKT2, SLC30A8, WFS1, NEUROD1, GCK, ABCC8, IGF2BP2, PDX1, ENPP1, KCNJ11, IRS1, IL6, GCGR, SLC2A4, SLC2A2, HNF1A, HNF1B, MAPK8IP1, PPARG, TCF7L2, LIPC |
response to peptide (GO:1901652) | - | 3.94 | 0.0 | SLC2A4, INSR, GCK, PTPN1, ENPP1, AKT2, IRS1, IL6, CAPN10, RETN, IRS2, GCGR, PPARG, TCF7L2 |
cellular response to peptide (GO:1901653) | - | 4.52 | 0.0 | SLC2A4, INSR, GCK, PTPN1, ENPP1, AKT2, IRS1, IL6, CAPN10, RETN, IRS2, GCGR, PPARG, TCF7L2 |
single-organism intracellular transport (GO:1902582) | NEW | 3.59 | 0.001 | AKT2, SLC2A4, NEUROD1, GPD2, INSR, PTPN1, MAPK8IP1, IL6, RETN, KCNJ11, GCGR, WFS1, IRS1, IRS2, MTNR1B, PPARG, TCF7L2 |
cellular response to organonitrogen compound (GO:0071417) | - | 3.87 | 0.0 | AKT2, SLC2A4, ABCC8, INSR, GCK, PTPN1, ENPP1, TCF7L2, IRS1, IL6, KCNJ11, RETN, CAPN10, IRS2, GCGR, MAPK8IP1, PPARG |
anion transport (GO:0006820) | - | 3.71 | 0.048 | SLC2A4, HNF1A, SLC2A2, INSR, ENPP1, PTPN1, IL6, IRS2, PPARG, HNF4A |
regulation of ion transmembrane transport (GO:0034765) | - | 3.77 | 0.046 | AKT2, NEUROD1, SLC2A2, ABCC8, MAPK8IP1, KCNJ11, IRS1, IL6, IRS2 |
signal transduction by phosphorylation (GO:0023014) | - | 3.79 | 0.019 | NEUROD1, INSR, IRS1, IL6, MAPK8IP1, GCGR, PPARG, HNF4A |
positive regulation of macromolecule metabolic process (GO:0010604) | - | 1.81 | 0.0 | WFS1, NEUROD1, INSR, GCK, PDX1, AKT2, RETN, IL6, HMGA1, IRS1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
response to wounding (GO:0009611) | - | 4.39 | 0.002 | PDX1, HNF1A, INSR, PTPN1, TCF7L2, IRS1, IL6, RETN, PPARG |
positive regulation of lipid metabolic process (GO:0045834) | - | 4.88 | 0.002 | AKT2, TCF7L2, IRS1, IL6, IRS2, PPARG |
cellular homeostasis (GO:0019725) | - | 3.23 | 0.011 | SLC30A8, PTPN1, NEUROD1, INSR, GCK, ENPP1, KCNJ11, IRS1, IL6, WFS1, RETN, IRS2, ABCC8, HNF1B, PPARG, GCGR |
regulation of peptide hormone secretion (GO:0090276) | - | 4.41 | 0.0 | SLC30A8, SLC2A4, NEUROD1, IRS2, GCK, PDX1, IL6, IRS1, KCNJ11, INSR, SLC2A2, ABCC8, CAPN10, MTNR1B, PPARG, GCGR, HNF4A, TCF7L2 |
positive regulation of peptide hormone secretion (GO:0090277) | - | 5.26 | 0.0 | SLC30A8, PDX1, IRS2, GCK, TCF7L2, IL6, CAPN10, PPARG |
detection of glucose (GO:0051594) | - | 8.63 | 0.015 | PDX1, GCK |
cell motility (GO:0048870) | NEW | 3.02 | 0.001 | AKT2, NEUROD1, ABCC8, INSR, PTPN1, PDX1, TCF7L2, IRS1, IL6, HMGA1, RETN, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
chemical homeostasis (GO:0048878) | - | 2.97 | 0.0 | PPP1R3A, ENPP1, PTPN1, KCNJ11, MTNR1B, PDX1, HNF1A, GCK, RETN, GCGR, WFS1, ABCC8, HNF1B, SLC30A8, NEUROD1, INSR, SLC2A4, TCF7L2, IRS1, IL6, LIPC, IRS2, PPARG, HNF4A |
secretion by cell (GO:0032940) | - | 3.59 | 0.011 | AKT2, SLC30A8, SLC2A4, NEUROD1, PTPN1, PDX1, TCF7L2, IRS1, IL6, HNF1A, HNF1B, PPARG, GCGR |
regulation of biological quality (GO:0065008) | - | 1.68 | 0.0 | SLC30A8, SLC2A4, NEUROD1, INSR, GCK, PTPN1, MTNR1B, IRS2, ENPP1, IL6, IRS1, KCNJ11, WFS1, HNF4A, TCF7L2, PDX1, HNF1A, HNF1B, PPARG, GCGR, LIPC |
positive regulation of cellular component organization (GO:0051130) | - | 2.68 | 0.035 | AKT2, NEUROD1, ABCC8, INSR, PTPN1, MAPK8IP1, TCF7L2, IRS1, IL6, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
regulation of cellular response to insulin stimulus (GO:1900076) | - | 5.65 | 0.002 | AKT2, INSR, ENPP1, PTPN1, IRS1, IL6, PPARG |
cell development (GO:0048468) | NEW | 3.28 | 0.014 | AKT2, NEUROD1, INSR, PTPN1, PDX1, TCF7L2, IRS1, IL6, HMGA1, RETN, HNF1B, PPARG, GCGR, HNF4A |
regulation of carbohydrate biosynthetic process (GO:0043255) | - | 5.25 | 0.0 | AKT2, INSR, GCK, ENPP1, TCF7L2, IRS1, IL6, IRS2, PPARG |
Fc receptor signaling pathway (GO:0038093) | NEW | 4.45 | 0.049 | PTPN1, MAPK8IP1, INSR, IRS1, IL6, HMGA1, IRS2, PPARG |
response to nitrogen compound (GO:1901698) | - | 3.12 | 0.0 | AKT2, SLC2A4, GCK, ABCC8, PTPN1, PDX1, ENPP1, PAX4, IRS1, IL6, KCNJ11, INSR, RETN, IRS2, CAPN10, GCGR, MAPK8IP1, PPARG, TCF7L2, HNF4A |
cellular response to nitrogen compound (GO:1901699) | - | 3.79 | 0.0 | AKT2, SLC2A4, GCK, ABCC8, PTPN1, CAPN10, ENPP1, IL6, RETN, KCNJ11, INSR, IRS1, IRS2, GCGR, MAPK8IP1, PPARG, TCF7L2 |
ion homeostasis (GO:0050801) | - | 3.42 | 0.0 | SLC30A8, PTPN1, INSR, GCK, ENPP1, WFS1, RETN, IL6, IRS1, IRS2, HNF1B, PPARG, GCGR, HNF4A |
response to estrogen (GO:0043627) | NEW | 5.25 | 0.015 | ABCC8, INSR, KCNJ11, IRS1, IL6, TCF7L2, PPARG, HNF4A |
signaling (GO:0023052) | NEW | 3.25 | 0.001 | AKT2, SLC2A4, NEUROD1, ABCC8, INSR, PTPN1, PDX1, IRS2, KCNJ11, IRS1, IL6, TCF7L2, HNF1A, GCGR, PPARG, MTNR1B |
negative regulation of cell communication (GO:0010648) | - | 2.66 | 0.044 | PTPN1, ENPP1, SLC2A4, KCNJ11, MTNR1B, PDX1, HNF1A, INSR, WFS1, GCGR, AKT2, MAPK8IP1, HNF1B, NEUROD1, TCF7L2, IRS1, IL6, HMGA1, LIPC, IRS2, PPARG, HNF4A |
regulation of signaling (GO:0023051) | - | 1.72 | 0.0 | PTPN1, ENPP1, TCF7L2, CAPN10, MTNR1B, PDX1, INSR, RETN, SLC2A2, WFS1, ABCC8, MAPK8IP1, HNF1B, SLC30A8, NEUROD1, GCK, KCNJ11, IRS1, IL6, IRS2, PPARG, HNF4A |
ameboidal cell migration (GO:0001667) | NEW | 4.71 | 0.004 | AKT2, NEUROD1, IL6, IRS1, TCF7L2, HMGA1, HNF1A, GCGR |
regulation of cell communication (GO:0010646) | - | 1.73 | 0.0 | PTPN1, ENPP1, KCNJ11, MTNR1B, PDX1, GCK, RETN, CAPN10, WFS1, SLC2A2, ABCC8, MAPK8IP1, HNF1B, SLC30A8, NEUROD1, INSR, TCF7L2, IRS1, IL6, IRS2, PPARG, HNF4A |
divalent inorganic cation homeostasis (GO:0072507) | - | 3.9 | 0.015 | SLC30A8, PTPN1, GCK, WFS1, IL6, IRS2, HNF1B, PPARG, GCGR |
amide transport (GO:0042886) | - | 5.19 | 0.001 | SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B, PPARG |
epithelium development (GO:0060429) | NEW | 4.57 | 0.011 | AKT2, HNF1A, INSR, PTPN1, TCF7L2, IRS1, IL6, HNF1B, PPARG, HNF4A |
lipid homeostasis (GO:0055088) | - | 5.0 | 0.037 | SLC2A4, INSR, IRS1, IL6, LIPC, IRS2, PPARG, HNF4A |
negative regulation of cell differentiation (GO:0045596) | - | 3.33 | 0.0 | AKT2, NEUROD1, MAPK8IP1, INSR, PTPN1, PDX1, ENPP1, IL6, IRS1, KCNJ11, HMGA1, RETN, IRS2, HNF1A, GCGR, PPARG, TCF7L2, HNF4A |
negative regulation of transcription, DNA-templated (GO:0045892) | - | 2.75 | 0.0 | AKT2, SLC2A4, NEUROD1, MAPK8IP1, GCK, PTPN1, MTNR1B, PDX1, PAX4, RETN, IL6, HMGA1, IRS1, IRS2, HNF1A, HNF1B, PPARG, TCF7L2, HNF4A |
response to acid chemical (GO:0001101) | - | 4.05 | 0.003 | PDX1, INSR, PTPN1, TCF7L2, IRS1, IL6, RETN, MAPK8IP1, GCGR, PPARG, HNF4A |
cellular cation homeostasis (GO:0030003) | - | 3.6 | 0.0 | SLC30A8, PTPN1, INSR, GCK, WFS1, IRS1, IL6, RETN, IRS2, HNF1B, PPARG, GCGR |
cation homeostasis (GO:0055080) | - | 3.46 | 0.003 | SLC30A8, PTPN1, INSR, GCK, WFS1, IRS1, IL6, RETN, IRS2, HNF1B, PPARG, GCGR |
anion homeostasis (GO:0055081) | NEW | 6.68 | 0.004 | IRS2, PPARG, HNF4A, INSR, ENPP1 |
cellular chemical homeostasis (GO:0055082) | - | 3.4 | 0.0 | SLC30A8, PTPN1, NEUROD1, INSR, GCK, ENPP1, IL6, IRS1, KCNJ11, WFS1, RETN, IRS2, ABCC8, HNF1B, PPARG, GCGR |
steroid metabolic process (GO:0008202) | - | 4.32 | 0.001 | SLC2A4, NEUROD1, MAPK8IP1, PDX1, IRS1, IL6, LIPC, IRS2, PPARG, HNF4A |
regulation of fat cell differentiation (GO:0045598) | - | 5.04 | 0.025 | INSR, ENPP1, IL6, IRS1, TCF7L2, PPARG |
negative regulation of developmental process (GO:0051093) | - | 3.17 | 0.0 | AKT2, PDX1, NEUROD1, MAPK8IP1, INSR, PTPN1, ENPP1, KCNJ11, IRS1, IL6, TCF7L2, HMGA1, RETN, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) | - | 4.29 | 0.049 | PDX1, NEUROD1, MAPK8IP1, TCF7L2, IRS1, IL6, SLC2A2, PPARG |
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) | - | 3.83 | 0.0 | AKT2, NEUROD1, SLC2A2, PDX1, TCF7L2, IRS1, WFS1, IL6, HMGA1, MAPK8IP1, HNF1B, PPARG, HNF4A |
aging (GO:0007568) | - | 4.16 | 0.001 | PDX1, HNF1A, INSR, AKT2, IRS1, IL6, HMGA1, RETN, PPARG, LIPC |
positive regulation of developmental process (GO:0051094) | - | 2.77 | 0.0 | AKT2, SLC2A4, NEUROD1, ABCC8, INSR, PTPN1, PDX1, MAPK8IP1, PAX4, IRS1, IL6, KCNJ11, HMGA1, RETN, IRS2, HNF1A, GCGR, PPARG, TCF7L2, HNF4A |
response to hormone (GO:0009725) | - | 3.33 | 0.0 | AKT2, SLC2A4, HNF1A, INSR, GCK, PTPN1, PDX1, ENPP1, PPP1R3A, RETN, IL6, KCNJ11, CAPN10, IRS1, TCF7L2, ABCC8, IRS2, GCGR, MAPK8IP1, PPARG, HNF4A |
regulation of binding (GO:0051098) | - | 4.08 | 0.014 | PPP1R3A, HNF1A, PDX1, TCF7L2, IL6, MAPK8IP1, NEUROD1, GCGR, PPARG |
peptide secretion (GO:0002790) | - | 5.67 | 0.0 | SLC30A8, PDX1, HNF1A, IL6, NEUROD1, HNF1B, PPARG |
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) | - | 2.81 | 0.012 | AKT2, SLC2A4, NEUROD1, MAPK8IP1, SLC2A2, PDX1, TCF7L2, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, GCGR, HNF4A |
positive regulation of protein kinase activity (GO:0045860) | - | 3.61 | 0.0 | PDX1, NEUROD1, MAPK8IP1, INSR, PTPN1, TCF7L2, RETN, IL6, WFS1, IRS1, IRS2, MTNR1B, PPARG, GCGR, HNF4A |
cellular response to endogenous stimulus (GO:0071495) | - | 3.33 | 0.0 | PTPN1, ENPP1, SLC2A4, KCNJ11, PDX1, INSR, RETN, GCGR, AKT2, ABCC8, MAPK8IP1, PAX4, NEUROD1, GCK, CAPN10, IRS1, IL6, HMGA1, IRS2, PPARG, TCF7L2, HNF4A |
response to extracellular stimulus (GO:0009991) | - | 3.71 | 0.0 | SLC2A4, INSR, GCK, PDX1, AKT2, IRS1, IL6, RETN, IRS2, GCGR, PPARG, TCF7L2, HNF4A |
positive regulation of cellular biosynthetic process (GO:0031328) | - | 2.3 | 0.0 | AKT2, PDX1, NEUROD1, INSR, GCK, IL6, IRS1, TCF7L2, HMGA1, IRS2, HNF1A, HNF1B, PPARG, HNF4A |
negative regulation of cellular biosynthetic process (GO:0031327) | - | 2.49 | 0.034 | PAX4, GCK, IGF2BP2, PDX1, ENPP1, TCF7L2, IL6, HMGA1, HNF1B, PPARG |
regulation of cellular biosynthetic process (GO:0031326) | - | 1.38 | 0.016 | AKT2, WFS1, NEUROD1, INSR, GCK, IGF2BP2, PDX1, ENPP1, PAX4, IRS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, MAPK8IP1, PPARG, TCF7L2, HNF4A |
positive regulation of cellular metabolic process (GO:0031325) | - | 1.81 | 0.005 | AKT2, NEUROD1, INSR, GCK, PDX1, TCF7L2, IRS1, WFS1, IL6, HMGA1, IRS2, HNF1A, HNF1B, PPARG, HNF4A |
negative regulation of cellular metabolic process (GO:0031324) | - | 2.01 | 0.022 | PAX4, GCK, IGF2BP2, PTPN1, PDX1, ENPP1, IL6, TCF7L2, HMGA1, MAPK8IP1, HNF1B, PPARG |
epithelial tube formation (GO:0072175) | NEW | 6.36 | 0.008 | HNF1B, MAPK8IP1, TCF7L2, IRS1 |
cellular response to insulin stimulus (GO:0032869) | - | 5.29 | 0.0 | AKT2, SLC2A4, GCK, INSR, PTPN1, ENPP1, IL6, IRS1, CAPN10, IRS2, PPARG |
response to insulin (GO:0032868) | - | 4.72 | 0.0 | SLC2A4, INSR, GCK, PTPN1, ENPP1, AKT2, IRS1, IL6, CAPN10, RETN, IRS2, PPARG |
regulation of cell death (GO:0010941) | - | 2.43 | 0.023 | PAX4, NEUROD1, MAPK8IP1, PDX1, CAPN10, IL6, WFS1, IRS2, HNF1B, PPARG, TCF7L2 |
morphogenesis of an epithelium (GO:0002009) | - | 4.08 | 0.021 | AKT2, HNF1A, PDX1, TCF7L2, IRS1, IL6, HMGA1, MAPK8IP1, HNF1B, PPARG |
growth (GO:0040007) | - | 3.8 | 0.005 | PDX1, HNF1A, INSR, GPD2, PTPN1, TCF7L2, IL6, HMGA1, MAPK8IP1, HNF1B, PPARG, GCGR |
regulation of growth (GO:0040008) | - | 3.26 | 0.004 | AKT2, HNF1A, INSR, PTPN1, ENPP1, TCF7L2, RETN, IL6, WFS1, IRS1, IRS2, HNF1B, PPARG, GCGR, HNF4A |
carbohydrate homeostasis (GO:0033500) | - | 4.6 | 0.0 | SLC2A4, NEUROD1, INSR, GCK, PDX1, IL6, IRS1, KCNJ11, GCGR, WFS1, IRS2, HNF1A, MTNR1B, PPARG, TCF7L2, HNF4A |
negative regulation of plasma membrane long-chain fatty acid transport (GO:0010748) | - | 8.34 | 0.029 | AKT2, IRS2 |
regulation of plasma membrane long-chain fatty acid transport (GO:0010746) | - | 8.34 | 0.049 | AKT2, IRS2 |
triglyceride homeostasis (GO:0070328) | - | 6.33 | 0.008 | PPARG, HNF4A, LIPC, RETN |
regulation of smooth muscle cell proliferation (GO:0048660) | - | 5.1 | 0.017 | IL6, PPARG, TCF7L2, RETN |
cell communication (GO:0007154) | - | 3.04 | 0.0 | AKT2, SLC2A4, NEUROD1, INSR, GCK, PTPN1, PDX1, TCF7L2, IRS1, IL6, KCNJ11, RETN, IRS2, ABCC8, HNF1A, GCGR, PPARG, MTNR1B |
monosaccharide transport (GO:0015749) | - | 5.76 | 0.021 | IL6, SLC2A4, HNF1A, SLC2A2, GCK |
regulation of protein phosphorylation (GO:0001932) | - | 2.57 | 0.0 | AKT2, PTPN1, NEUROD1, ABCC8, INSR, PDX1, ENPP1, TCF7L2, IRS1, WFS1, IL6, KCNJ11, HMGA1, RETN, IRS2, GCGR, MAPK8IP1, PPARG, MTNR1B, HNF4A |
positive regulation of protein phosphorylation (GO:0001934) | - | 2.95 | 0.0 | AKT2, NEUROD1, MAPK8IP1, INSR, PTPN1, PDX1, TCF7L2, IRS1, WFS1, IL6, HMGA1, RETN, IRS2, MTNR1B, PPARG, GCGR, HNF4A |