Disease table of NEMALINE MYOPATHY OMIM ID: PS161800

Gene-disease associations table

Gene	Associated with NEMALINE MYOPATHY in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TNNT1	ClinVar, OMIM	HGNC link	19q13.42	1	PS161800
ACTA1	ClinVar, OMIM, HUMSAVAR	HGNC link	1q42.13	3	255310, PS161800, 616852
TPM3	ClinVar, OMIM, HUMSAVAR	HGNC link	1q21.3	2	255310, PS161800
NEB	ClinVar, OMIM	HGNC link	2q23.3	2	236750, PS161800
TPM2	ClinVar, OMIM, HUMSAVAR	HGNC link	9p13.3	3	601680, PS161800, 108120
KLHL41	ClinVar, OMIM, HUMSAVAR	HGNC link	2q31.1	1	PS161800
KLHL40	ClinVar, OMIM, HUMSAVAR	HGNC link	3p22.1	1	PS161800
KBTBD13	ClinVar, OMIM, HUMSAVAR	HGNC link	15q22.31	1	PS161800
CFL2	ClinVar, OMIM, HUMSAVAR	HGNC link	14q13.1	1	PS161800
LMOD3	ClinVar, OMIM, HUMSAVAR	HGNC link	3p14.1	1	PS161800

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1q	2	TPM3, ACTA1
2q	2	NEB, KLHL41
3p	2	KLHL40, LMOD3

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
1	2	TPM3, ACTA1
3	2	KLHL40, LMOD3
2	2	NEB, KLHL41

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
ACTA1	YES	4	AR, FOS, JUN, KLF3	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TNNT1	ACTA1	No	4	KAT5, VIM, MORF4L1, TRIM63
TNNT1	TPM3	Yes	4	TPM1, TPM3, HSP90AB1, TNNT1
TNNT1	NEB	No	2	TPM1, TRIM63
TNNT1	TPM2	No	3	TPM1, TPM3, ZNF250
ACTA1	TPM3	No	16	HDAC8, TPM1, CUL7, CDK2, ACTB, ADD1, OBSL1, MYH9, PPP1CB, CAPZA2, TRIP6, MYO18A, NTRK1, MYH10, MCM2, TPM2
ACTA1	NEB	No	7	XIRP2, MCM2, TRIM55, TRIM63, XIRP1, MAPK14, TPM2
ACTA1	TPM2	Yes	14	MYO1C, AKT1, CDK2, ACTB, ADD1, MYH9, PPP1CB, CAPZA2, TPM1, MYO18A, MYH10, LIMA1, DSTN, TPM2
ACTA1	CFL2	No	10	MYO1C, CFL1, ACTG1, MYH9, PPP1CB, CAPZA2, MYO18A, DSTN, LIMA1, TPM1
TPM3	NEB	No	4	SP1, MCM2, TPM1, TPM2
TPM3	TPM2	Yes	32	TPM1, CDK2, ANLN, MYO19, COX4I1, MYO5C, ACTN4, TPM2, SP1, IQGAP1, ACTN1, ITGA5, CKMT1B, MYO18A, AHCYL1, LRRK2, PPP1CB, ACTB, UQCRC2, TPM4, ACTN2, CKMT1A, NDUFB10, STMN1, CALML3, ADD1, ATP5F1, MYH9, TPM3, CAPZA2, MYH10, PDLIM7
TPM3	KLHL41	No	1	CUL3
TPM3	KBTBD13	No	1	CUL3
TPM3	CFL2	No	8	TPM1, MYO19, IQGAP1, MYH9, PPP1CB, CAPZA2, MYO18A, PAN2
NEB	TPM2	Yes	3	SP1, TPM1, TPM2
NEB	KLHL40	Yes	0
NEB	LMOD3	No	1	KLHL40
TPM2	KLHL40	No	1	NEB
TPM2	CFL2	No	13	MYO1C, MYO19, CORO1C, FLNA, IQGAP1, MYH9, PPP1CB, CAPZA2, SYNPO, MYO18A, DSTN, LIMA1, TPM1
KLHL41	KBTBD13	No	1	CUL3
KLHL40	LMOD3	Yes	0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
TNNT1	ACTA1	No	-	9	ACTN2, TPM1, MYH6, MYH8, TPM3, MYH14, TNNC2, MYH3, TPM2
TNNT1	TPM3	Yes	binding	27	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYH3, MYBPC1, TPM2, MYL1, TNNT2, MYL3, MYBPC2, MYH14, NEB, TNNC2, MYH8, TNNI3, MYBPC3, ACTN2, MYL2, TNNC1, TNNI1, MYH6, TTN, TNNI2, TPM4
TNNT1	NEB	Yes	binding	26	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, TPM3, MYBPC1, TPM2, MYL1, TNNT2, MYL3, MYBPC2, MYL2, MYH6, MYH8, TNNC2, TNNI3, MYBPC3, ACTN2, TTN, TNNI1, MYH3, TNNC1, TNNI2, TPM4
TNNT1	TPM2	Yes	binding	27	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYH3, MYBPC1, TNNC2, MYL1, TNNT2, MYL3, MYBPC2, MYH14, NEB, MYL2, MYH8, TPM3, TNNI3, MYBPC3, ACTN2, TNNC1, TNNI1, MYH6, TTN, TNNI2, TPM4
ACTA1	TPM3	Yes	binding	19	ACTN2, TPM1, MYH11, ACTN1, MYH7, MYH8, CFL1, MYH3, ITGA1, PXN, MYH9, TNNC2, MYH6, TLN1, MYH14, VCL, DSTN, UBC, TPM2
ACTA1	NEB	No	-	9	ACTN2, TPM1, MYH3, MYH8, TPM3, TNNC2, MYH6, WASL, TPM2
ACTA1	TPM2	Yes	binding	22	TPM1, MYH8, VCL, ACTN1, MYH9, MYH3, TLN1, MYH11, MYH2, MYH14, MYH1, TNNC2, MYH6, MYH7, MYH4, PXN, DSTN, ACTN2, CFL1, TPM3, ITGA1, UBC
TPM3	NEB	Yes	binding	26	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYH3, MYBPC1, TPM2, MYL1, TNNT2, MYH6, MYBPC2, MYL2, MYH8, TNNC2, TNNT1, TNNI3, MYBPC3, ACTN2, TTN, TNNI1, MYL3, TNNC1, TNNI2, TPM4
TPM3	TPM2	Yes	binding	51	TPM1, CALD1, TNNI1, MYH8, VCL, ACTN1, PXN, TNNT3, VIM, MYH3, TLN1, MYL6B, MYL12B, TNNC2, MYBPC1, MYL1, MYH11, TNNT1, MYBPC2, ACTA1, MYH14, NEB, MYBPC3, MYL2, ACTG2, MYH6, SORBS3, MYL4, ITGB5, ACTA2, ACTC1, TNNI3, MYL9, MYH7, TNNT2, DSTN, ACTN2, CFL1, MYL6, TTN, DES, SORBS1, MYL3, ITGA1, TNNC1, TNNI2, LMOD1, TMOD1, UBC, TPM4, MYH9
NEB	TPM2	Yes	binding	26	TPM1, TMOD1, DES, MYL4, TNNT3, VIM, MYL3, MYBPC1, MYL2, MYL1, TNNT2, MYH3, MYBPC2, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYBPC3, ACTN2, TTN, TNNI1, TPM3, TNNC1, TNNI2, TPM4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TPM3	TPM2	Yes	2	TPM4, TPM1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Hypertrophic cardiomyopathy (HCM)	hsa05410	6.21	2	TPM2, TPM3
Cardiac muscle contraction	hsa04260	6.34	2	TPM2, TPM3
Dilated cardiomyopathy	hsa05414	6.08	2	TPM2, TPM3
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	2	TPM2, TPM3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Hypertrophic cardiomyopathy (HCM) (hsa05410)	-	6.21	0.012	TPM2, TPM3
Cardiac muscle contraction (hsa04260)	-	6.34	0.01	TPM2, TPM3
Dilated cardiomyopathy (hsa05414)	-	6.08	0.009	NEB, TPM2, TPM3
Adrenergic signaling in cardiomyocytes (hsa04261)	-	5.44	0.034	TPM2, TPM3

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Muscle contraction	R-HSA-397014	6.96	5	TPM2, NEB, ACTA1, TPM3, TNNT1
Striated Muscle Contraction	R-HSA-390522	7.81	5	TPM2, NEB, ACTA1, TPM3, TNNT1
Smooth Muscle Contraction	R-HSA-445355	8.23	2	TPM2, TPM3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Muscle contraction (R-HSA-397014)	-	6.96	0.0	TPM2, NEB, ACTA1, TPM3, TNNT1
Striated Muscle Contraction (R-HSA-390522)	-	7.81	0.0	TPM2, NEB, ACTA1, TPM3, TNNT1
Smooth Muscle Contraction (R-HSA-445355)	-	8.23	0.015	TPM2, TPM3

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	8	CFL2, LMOD3, TNNT1, ACTA1, KLHL41, TPM3, NEB, TPM2
protein binding (GO:0005515)	0.46	8	CFL2, LMOD3, TNNT1, ACTA1, KLHL41, TPM3, NEB, TPM2
cytoskeletal protein binding (GO:0008092)	3.02	7	CFL2, LMOD3, TNNT1, ACTA1, TPM3, NEB, TPM2
actin binding (GO:0003779)	3.74	5	LMOD3, TPM2, NEB, CFL2, TPM3
ubiquitin-like protein transferase activity (GO:0019787)	3.69	3	KLHL41, KBTBD13, KLHL40
catalytic activity (GO:0003824)	1.05	3	KLHL41, KBTBD13, KLHL40
transferase activity (GO:0016740)	1.95	3	KLHL41, KBTBD13, KLHL40
ubiquitin-protein transferase activity (GO:0004842)	3.73	3	KLHL41, KBTBD13, KLHL40
structural molecule activity (GO:0005198)	3.1	3	NEB, ACTA1, TPM2
tropomyosin binding (GO:0005523)	7.1	2	LMOD3, TNNT1
structural constituent of muscle (GO:0008307)	6.02	2	NEB, TPM2

NET-GE enrichment

Term	New enriched term	IC	Genes
actin binding (GO:0003779)	-	3.74	TPM2, NEB, ACTA1, CFL2, TPM3
tropomyosin binding (GO:0005523)	-	7.1	NEB, LMOD3, TNNT1
structural constituent of muscle (GO:0008307)	-	6.02	NEB, CFL2, TPM2
cytoskeletal protein binding (GO:0008092)	-	3.02	CFL2, LMOD3, TNNT1, ACTA1, TPM3, NEB, TPM2

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	10	CFL2, KLHL40, TNNT1, KBTBD13, ACTA1, KLHL41, TPM3, NEB, LMOD3, TPM2
single-organism cellular process (GO:0044763)	0.65	9	CFL2, KLHL40, TNNT1, ACTA1, KLHL41, TPM3, NEB, LMOD3, TPM2
single-organism process (GO:0044699)	0.48	9	CFL2, KLHL40, TNNT1, ACTA1, KLHL41, TPM3, NEB, LMOD3, TPM2
biological regulation (GO:0065007)	0.39	8	CFL2, TNNT1, KLHL40, ACTA1, NEB, KLHL41, LMOD3, TPM2
actin filament-based process (GO:0030029)	3.94	8	CFL2, LMOD3, TNNT1, ACTA1, KLHL41, TPM3, NEB, TPM2
multicellular organismal process (GO:0032501)	1.45	7	TNNT1, KLHL40, ACTA1, TPM3, KLHL41, LMOD3, TPM2
regulation of biological process (GO:0050789)	0.45	7	CFL2, TNNT1, KLHL40, ACTA1, KLHL41, NEB, LMOD3
muscle system process (GO:0003012)	4.18	6	TNNT1, LMOD3, ACTA1, TPM3, KLHL41, TPM2
muscle contraction (GO:0006936)	4.37	6	TNNT1, LMOD3, ACTA1, TPM3, KLHL41, TPM2
system process (GO:0003008)	2.3	6	TNNT1, LMOD3, ACTA1, TPM3, KLHL41, TPM2
developmental process (GO:0032502)	1.36	5	LMOD3, NEB, ACTA1, KLHL41, KLHL40
single-organism developmental process (GO:0044767)	1.49	5	LMOD3, KLHL41, ACTA1, NEB, KLHL40
cellular component organization (GO:0016043)	1.24	5	KLHL41, CFL2, ACTA1, NEB, LMOD3
regulation of cellular process (GO:0050794)	0.5	5	LMOD3, KLHL41, CFL2, NEB, KLHL40
muscle filament sliding (GO:0030049)	6.09	5	TPM2, NEB, ACTA1, TPM3, TNNT1
actin filament-based movement (GO:0030048)	5.54	5	TPM2, NEB, ACTA1, TPM3, TNNT1
actin-myosin filament sliding (GO:0033275)	6.09	5	TPM2, NEB, ACTA1, TPM3, TNNT1
actin-mediated cell contraction (GO:0070252)	5.88	5	TPM2, NEB, ACTA1, TPM3, TNNT1
movement of cell or subcellular component (GO:0006928)	2.61	5	TPM2, NEB, ACTA1, TPM3, TNNT1
cellular component organization or biogenesis (GO:0071840)	1.22	5	KLHL41, CFL2, ACTA1, NEB, LMOD3
anatomical structure development (GO:0048856)	1.58	4	KLHL41, ACTA1, NEB, KLHL40
regulation of cellular component organization (GO:0051128)	2.01	4	KLHL41, CFL2, NEB, LMOD3
actomyosin structure organization (GO:0031032)	5.4	3	KLHL41, CFL2, LMOD3
regulation of organelle organization (GO:0033043)	2.72	3	NEB, CFL2, LMOD3
protein modification by small protein conjugation or removal (GO:0070647)	2.95	3	KLHL41, KBTBD13, KLHL40
cell development (GO:0048468)	3.28	3	KLHL41, ACTA1, KLHL40
actin cytoskeleton organization (GO:0030036)	4.1	3	KLHL41, CFL2, LMOD3
cellular protein metabolic process (GO:0044267)	1.63	3	KLHL41, KBTBD13, KLHL40
regulation of actin filament length (GO:0030832)	4.65	3	NEB, CFL2, LMOD3
cellular macromolecule metabolic process (GO:0044260)	0.93	3	KLHL41, KBTBD13, KLHL40
organic substance metabolic process (GO:0071704)	0.63	3	KLHL41, KBTBD13, KLHL40
cellular developmental process (GO:0048869)	1.82	3	KLHL41, ACTA1, KLHL40
regulation of cytoskeleton organization (GO:0051493)	3.72	3	NEB, CFL2, LMOD3
regulation of anatomical structure size (GO:0090066)	3.78	3	NEB, CFL2, LMOD3
protein modification by small protein conjugation (GO:0032446)	3.1	3	KLHL41, KBTBD13, KLHL40
negative regulation of biological process (GO:0048519)	1.33	3	LMOD3, KLHL40, TNNT1
regulation of biological quality (GO:0065008)	1.68	3	NEB, CFL2, LMOD3
muscle cell development (GO:0055001)	5.29	3	KLHL41, ACTA1, KLHL40
striated muscle cell development (GO:0055002)	5.42	3	KLHL41, ACTA1, KLHL40
actin filament organization (GO:0007015)	4.54	3	CFL2, ACTA1, LMOD3
skeletal muscle fiber development (GO:0048741)	6.36	3	KLHL41, ACTA1, KLHL40
regulation of actin filament-based process (GO:0032970)	3.97	3	NEB, CFL2, LMOD3
muscle fiber development (GO:0048747)	5.8	3	KLHL41, ACTA1, KLHL40
macromolecule modification (GO:0043412)	1.73	3	KLHL41, KBTBD13, KLHL40
protein modification process (GO:0036211)	1.79	3	KLHL41, KBTBD13, KLHL40
myotube cell development (GO:0014904)	6.23	3	KLHL41, ACTA1, KLHL40
metabolic process (GO:0008152)	0.58	3	KLHL41, KBTBD13, KLHL40
regulation of actin cytoskeleton organization (GO:0032956)	4.09	3	NEB, CFL2, LMOD3
organelle organization (GO:0006996)	2.02	3	KLHL41, CFL2, LMOD3
primary metabolic process (GO:0044238)	0.69	3	KLHL41, KBTBD13, KLHL40
cytoskeleton organization (GO:0007010)	3.22	3	KLHL41, CFL2, LMOD3
protein metabolic process (GO:0019538)	1.45	3	KLHL41, KBTBD13, KLHL40
cellular metabolic process (GO:0044237)	0.69	3	KLHL41, KBTBD13, KLHL40
macromolecule metabolic process (GO:0043170)	0.83	3	KLHL41, KBTBD13, KLHL40
protein ubiquitination (GO:0016567)	3.28	3	KLHL41, KBTBD13, KLHL40
single-organism organelle organization (GO:1902589)	2.68	3	KLHL41, CFL2, LMOD3
cellular protein modification process (GO:0006464)	1.79	3	KLHL41, KBTBD13, KLHL40
regulation of cellular component size (GO:0032535)	4.21	3	NEB, CFL2, LMOD3
striated muscle contraction (GO:0006941)	5.37	2	KLHL41, TNNT1
cellular component assembly (GO:0022607)	2.14	2	KLHL41, LMOD3
regulation of actin filament depolymerization (GO:0030834)	5.88	2	CFL2, LMOD3
regulation of metabolic process (GO:0019222)	1.02	2	ACTA1, KLHL40
single-multicellular organism process (GO:0044707)	1.78	2	ACTA1, KLHL40
myofibril assembly (GO:0030239)	6.43	2	KLHL41, LMOD3
regulation of macromolecule metabolic process (GO:0060255)	1.08	2	ACTA1, KLHL40
regulation of protein depolymerization (GO:1901879)	5.44	2	CFL2, LMOD3
cellular component assembly involved in morphogenesis (GO:0010927)	4.29	2	KLHL41, LMOD3
regulation of actin polymerization or depolymerization (GO:0008064)	4.65	2	CFL2, LMOD3
regulation of cellular component biogenesis (GO:0044087)	3.08	2	KLHL41, LMOD3
sarcomere organization (GO:0045214)	6.4	2	KLHL41, CFL2
negative regulation of cellular process (GO:0048523)	1.41	2	LMOD3, KLHL40
regulation of multicellular organismal process (GO:0051239)	1.87	2	KLHL41, TNNT1
positive regulation of biological process (GO:0048518)	1.2	2	CFL2, ACTA1
regulation of protein complex disassembly (GO:0043244)	5.27	2	CFL2, LMOD3
organelle assembly (GO:0070925)	3.75	2	KLHL41, LMOD3
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	2	KLHL41, LMOD3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
actomyosin structure organization (GO:0031032)	-	5.4	0.001	KLHL41, CFL2, ACTA1, NEB
actin filament-based process (GO:0030029)	-	3.94	0.0	CFL2, TNNT1, ACTA1, KLHL41, TPM3, NEB, TPM2
regulation of actin filament-based process (GO:0032970)	-	3.97	0.023	NEB, CFL2, ACTA1, TPM3, TNNT1
muscle contraction (GO:0006936)	-	4.37	0.0	CFL2, TNNT1, ACTA1, KLHL41, TPM3, NEB, TPM2
muscle system process (GO:0003012)	-	4.18	0.0	CFL2, TNNT1, ACTA1, KLHL41, TPM3, NEB, TPM2
cellular component movement (GO:0006928)	-	2.61	0.031	TPM2, NEB, ACTA1, TPM3, TNNT1
muscle filament sliding (GO:0030049)	-	6.09	0.0	TPM2, NEB, ACTA1, TPM3, TNNT1
actin filament-based movement (GO:0030048)	-	5.54	0.0	TPM2, NEB, ACTA1, TPM3, TNNT1
actin-myosin filament sliding (GO:0033275)	-	6.09	0.0	TPM2, NEB, ACTA1, TPM3, TNNT1
sarcomere organization (GO:0045214)	-	6.4	0.004	NEB, ACTA1, CFL2
regulation of actin cytoskeleton organization (GO:0032956)	-	4.09	0.016	NEB, CFL2, ACTA1, TPM3, TNNT1
actin-mediated cell contraction (GO:0070252)	-	5.88	0.0	TPM2, NEB, ACTA1, TPM3, TNNT1
organelle assembly (GO:0070925)	-	3.75	0.025	KLHL41, CFL2, ACTA1, TPM3, TNNT1
regulation of cellular component size (GO:0032535)	-	4.21	0.038	NEB, ACTA1, CFL2, TPM3
system process (GO:0003008)	-	2.3	0.016	TPM2, KLHL41, ACTA1, TPM3, TNNT1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	10	CFL2, KLHL40, TNNT1, KBTBD13, ACTA1, KLHL41, TPM3, NEB, LMOD3, TPM2
cell part (GO:0044464)	0.11	10	CFL2, KLHL40, TNNT1, KBTBD13, ACTA1, KLHL41, TPM3, NEB, LMOD3, TPM2
cytoplasm (GO:0005737)	1.01	9	CFL2, LMOD3, KLHL40, KBTBD13, ACTA1, NEB, TPM3, KLHL41, TPM2
cytoplasmic part (GO:0044444)	0.82	9	CFL2, KLHL40, TNNT1, ACTA1, KLHL41, TPM3, NEB, LMOD3, TPM2
organelle part (GO:0044422)	0.79	9	CFL2, KLHL40, TNNT1, ACTA1, KLHL41, TPM3, NEB, LMOD3, TPM2
contractile fiber part (GO:0044449)	4.53	9	CFL2, KLHL40, TNNT1, ACTA1, KLHL41, TPM3, NEB, LMOD3, TPM2
intracellular organelle part (GO:0044446)	0.81	8	CFL2, LMOD3, TNNT1, ACTA1, KLHL41, TPM3, NEB, TPM2
cytoskeleton (GO:0005856)	2.55	7	CFL2, LMOD3, ACTA1, NEB, TPM3, KLHL41, TPM2
intracellular organelle (GO:0043229)	0.51	7	CFL2, LMOD3, ACTA1, NEB, TPM3, KLHL41, TPM2
non-membrane-bounded organelle (GO:0043228)	1.76	7	CFL2, LMOD3, ACTA1, NEB, TPM3, KLHL41, TPM2
organelle (GO:0043226)	0.4	7	CFL2, LMOD3, ACTA1, NEB, TPM3, KLHL41, TPM2
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	7	CFL2, LMOD3, ACTA1, NEB, TPM3, KLHL41, TPM2
cytoskeletal part (GO:0044430)	2.49	6	TNNT1, LMOD3, ACTA1, TPM3, NEB, TPM2
protein complex (GO:0043234)	1.51	5	KLHL40, KBTBD13, KLHL41, TNNT1, NEB
macromolecular complex (GO:0032991)	1.35	5	KLHL40, KBTBD13, KLHL41, TNNT1, NEB
cytosol (GO:0005829)	1.68	5	TPM2, NEB, ACTA1, TPM3, TNNT1
membrane-bounded organelle (GO:0043227)	0.47	5	NEB, CFL2, ACTA1, KLHL41, TPM3
extracellular organelle (GO:0043230)	1.89	4	NEB, ACTA1, CFL2, TPM3
extracellular exosome (GO:0070062)	1.89	4	NEB, ACTA1, CFL2, TPM3
membrane-bounded vesicle (GO:0031988)	1.71	4	NEB, ACTA1, CFL2, TPM3
extracellular vesicle (GO:1903561)	1.89	4	NEB, ACTA1, CFL2, TPM3
extracellular region part (GO:0044421)	1.57	4	NEB, ACTA1, CFL2, TPM3
vesicle (GO:0031982)	1.64	4	NEB, ACTA1, CFL2, TPM3
myofilament (GO:0036379)	7.16	3	NEB, ACTA1, LMOD3
actin cytoskeleton (GO:0015629)	4.39	3	NEB, ACTA1, CFL2
ubiquitin ligase complex (GO:0000151)	4.23	3	KLHL41, KBTBD13, KLHL40
transferase complex (GO:1990234)	3.32	3	KLHL41, KBTBD13, KLHL40
cullin-RING ubiquitin ligase complex (GO:0031461)	4.79	3	KLHL41, KBTBD13, KLHL40
striated muscle thin filament (GO:0005865)	7.4	3	NEB, ACTA1, LMOD3
Cul3-RING ubiquitin ligase complex (GO:0031463)	5.64	3	KLHL41, KBTBD13, KLHL40
catalytic complex (GO:1902494)	2.9	3	KLHL41, KBTBD13, KLHL40
actin filament bundle (GO:0032432)	5.74	2	ACTA1, TPM3
stress fiber (GO:0001725)	5.81	2	ACTA1, TPM3
M band (GO:0031430)	6.76	2	KLHL41, LMOD3
extracellular space (GO:0005615)	2.63	2	CFL2, ACTA1
nucleus (GO:0005634)	1.07	2	KLHL41, CFL2
A band (GO:0031672)	7.09	2	LMOD3, KLHL40
I band (GO:0031674)	6.67	2	CFL2, KLHL40
contractile actin filament bundle (GO:0097517)	5.81	2	ACTA1, TPM3
sarcomere (GO:0030017)	5.95	2	NEB, ACTA1
intracellular membrane-bounded organelle (GO:0043231)	0.6	2	KLHL41, CFL2
cell projection (GO:0042995)	2.47	2	KLHL41, ACTA1
muscle thin filament tropomyosin (GO:0005862)	8.42	2	TPM2, TPM3
actomyosin (GO:0042641)	5.66	2	ACTA1, TPM3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
actin filament bundle (GO:0032432)	-	5.74	0.015	ACTA1, TPM3
myofilament (GO:0036379)	-	7.16	0.003	NEB, ACTA1
actin cytoskeleton (GO:0015629)	-	4.39	0.005	NEB, ACTA1, CFL2
intracellular non-membrane-bounded organelle (GO:0043232)	-	1.76	0.027	CFL2, LMOD3, ACTA1, KLHL41, TPM3, NEB
stress fiber (GO:0001725)	-	5.81	0.013	ACTA1, TPM3
cytoskeleton (GO:0005856)	-	2.55	0.0	CFL2, LMOD3, TNNT1, ACTA1, KLHL41, TPM3, NEB, TPM2
I band (GO:0031674)	-	6.67	0.036	CFL2, ACTA1
non-membrane-bounded organelle (GO:0043228)	-	1.76	0.027	CFL2, LMOD3, ACTA1, KLHL41, TPM3, NEB
striated muscle thin filament (GO:0005865)	-	7.4	0.002	NEB, ACTA1
actomyosin (GO:0042641)	-	5.66	0.019	ACTA1, TPM3
muscle thin filament tropomyosin (GO:0005862)	-	8.42	0.0	TPM2, TPM3
contractile fiber part (GO:0044449)	-	4.53	0.0	CFL2, KLHL40, TNNT1, ACTA1, KLHL41, TPM3, NEB, TPM2