Gene table of TREX1 : three prime repair exonuclease 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with TREX1	OMIM link	Number of associated genes	genes
PS610448	CHILBLAIN LUPUS	ClinVar, OMIM, HUMSAVAR	link to OMIM	2	TREX1, SAMHD1
152700	SYSTEMIC LUPUS ERYTHEMATOSUS	OMIM, HUMSAVAR	link to OMIM	6	FCGR2A, PTPN22, CTLA4, TREX1, FCGR2B, DNASE1
PS225750	AICARDI-GOUTIERES SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	7	IFIH1, RNASEH2B, RNASEH2C, RNASEH2A, ADAR, TREX1, SAMHD1
192315	VASCULOPATHY, RETINAL, WITH CEREBRAL LEUKODYSTROPHY	ClinVar, OMIM	link to OMIM	1	TREX1

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Cytosolic DNA-sensing pathway	hsa04623	6.79

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
IRF3-mediated induction of type I IFN	R-HSA-3270619	9.28
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.08
Immune System	R-HSA-168256	2.37
Regulation by TREX1	R-HSA-3248023	12.98
Innate Immune System	R-HSA-168249	3.17
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.94
STING mediated induction of host immune responses	R-HSA-1834941	8.98

Associated GO terms for Molecular function

GO term	GO ID	GO IC
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	GO:0016796	5.89
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
cation binding	GO:0043169	1.4
3'-5' exonuclease activity	GO:0008408	5.83
exodeoxyribonuclease activity	GO:0004529	6.79
exonuclease activity	GO:0004527	5.33
ion binding	GO:0043167	1.36
protein complex binding	GO:0032403	3.09
metal ion binding	GO:0046872	1.41
MutSalpha complex binding	GO:0032407	8.13
single-stranded DNA binding	GO:0003697	5.17
identical protein binding	GO:0042802	2.63
protein homodimerization activity	GO:0042803	3.16
hydrolase activity	GO:0016787	1.9
exodeoxyribonuclease III activity	GO:0008853	8.35
hydrolase activity, acting on ester bonds	GO:0016788	3.1
catalytic activity	GO:0003824	1.05
exodeoxyribonuclease activity, producing 5'-phosphomonoesters	GO:0016895	6.79
nuclease activity	GO:0004518	4.33
organic cyclic compound binding	GO:0097159	1.05
deoxyribonuclease activity	GO:0004536	5.48
MutLalpha complex binding	GO:0032405	7.95
protein binding	GO:0005515	0.46
protein dimerization activity	GO:0046983	2.72
mismatch repair complex binding	GO:0032404	7.66
3'-5'-exodeoxyribonuclease activity	GO:0008296	7.54