Disease table of AICARDI-GOUTIERES SYNDROME OMIM ID: PS225750

Gene-disease associations table

GeneAssociated with AICARDI-GOUTIERES SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IFIH1ClinVar, OMIM, HUMSAVARHGNC link2q24.22PS182250, PS225750
SAMHD1ClinVar, OMIM, HUMSAVARHGNC link20q11.232PS610448, PS225750
RNASEH2CClinVar, OMIM, HUMSAVARHGNC link11q13.11PS225750
RNASEH2BClinVar, OMIM, HUMSAVARHGNC link13q14.31PS225750
ADARClinVar, OMIM, HUMSAVARHGNC link1q21.32PS179850, PS225750
TREX1ClinVar, OMIM, HUMSAVARHGNC link3p21.314PS225750, 192315, PS610448, 152700
RNASEH2AClinVar, OMIM, HUMSAVARHGNC link19p13.131PS225750

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
IFIH1SAMHD1No1APP
SAMHD1ADARNo4NTRK1, CUL3, EGFR, RNF2
RNASEH2CRNASEH2BYes1RNASEH2A
RNASEH2CRNASEH2AYes1RNASEH2B
RNASEH2BADARNo1THOC2
RNASEH2BRNASEH2AYes3AP1M1, HIST1H2BG, RNASEH2C
ADARRNASEH2ANo1FBXW11
TREX1RNASEH2ANo1MOV10

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
IFIH1SAMHD1No-1UBC
IFIH1RNASEH2CNo-1UBC
IFIH1ADARNo-2UBC, IFIT1
IFIH1RNASEH2ANo-1UBC
SAMHD1RNASEH2CNo-1UBC
SAMHD1ADARNo-1UBC
SAMHD1RNASEH2ANo-1UBC
RNASEH2CRNASEH2BYesbinding1RNASEH2A
RNASEH2CADARNo-1UBC
RNASEH2CRNASEH2AYesbinding2UBC, RNASEH2B
RNASEH2BTREX1No-1PCNA
RNASEH2BRNASEH2AYesbinding1RNASEH2C
ADARTREX1No-1IRF3
ADARRNASEH2ANo-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
RNASEH2CRNASEH2BYes1RNASEH2A
RNASEH2CRNASEH2AYes1RNASEH2B
RNASEH2BRNASEH2AYes1RNASEH2C

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
RNASEH2CRNASEH2BYes3RNASEH2B, RNASEH2C, RNASEH2A
RNASEH2CRNASEH2AYes3RNASEH2B, RNASEH2C, RNASEH2A
RNASEH2BRNASEH2AYes3RNASEH2B, RNASEH2C, RNASEH2A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
DNA replicationhsa030307.483RNASEH2B, RNASEH2C, RNASEH2A
Influenza Ahsa051645.212IFIH1, ADAR
Measleshsa051625.62IFIH1, ADAR
Cytosolic DNA-sensing pathwayhsa046236.792TREX1, ADAR

NET-GE enrichment

Term New enriched termICP valueGenes
DNA replication (hsa03030) -7.480.0RNASEH2B, RNASEH2C, RNASEH2A
Replication and repairNEW5.410.006RNASEH2B, RNASEH2C, RNASEH2A
Cytosolic DNA-sensing pathway (hsa04623) -6.790.046TREX1, ADAR
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.374SAMHD1, TREX1, IFIH1, ADAR
Cytokine Signaling in Immune systemR-HSA-12802153.742SAMHD1, ADAR
Interferon SignalingR-HSA-9135314.952SAMHD1, ADAR
Innate Immune SystemR-HSA-1682493.172IFIH1, TREX1
Interferon alpha/beta signalingR-HSA-9097336.042SAMHD1, ADAR

NET-GE enrichment

Term New enriched termICP valueGenes
Immune System (R-HSA-168256) -2.370.03IFIH1, TREX1, SAMHD1, ADAR
Interferon alpha/beta signaling (R-HSA-909733) -6.040.042SAMHD1, ADAR
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
hydrolase activity (GO:0016787) 1.97SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
catalytic activity (GO:0003824) 1.057SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
cation binding (GO:0043169) 1.45SAMHD1, TREX1, ADAR, RNASEH2A, IFIH1
organic cyclic compound binding (GO:0097159) 1.055SAMHD1, TREX1, ADAR, RNASEH2A, IFIH1
hydrolase activity, acting on ester bonds (GO:0016788) 3.15RNASEH2B, SAMHD1, TREX1, RNASEH2C, RNASEH2A
ion binding (GO:0043167) 1.365ADAR, SAMHD1, TREX1, IFIH1, RNASEH2A
binding (GO:0005488) 0.185ADAR, IFIH1, TREX1, SAMHD1, RNASEH2A
nucleic acid binding (GO:0003676) 1.445ADAR, SAMHD1, TREX1, IFIH1, RNASEH2A
metal ion binding (GO:0046872) 1.415SAMHD1, TREX1, RNASEH2A, ADAR, IFIH1
heterocyclic compound binding (GO:1901363) 1.065ADAR, IFIH1, TREX1, SAMHD1, RNASEH2A
nuclease activity (GO:0004518) 4.334RNASEH2B, TREX1, RNASEH2C, RNASEH2A
RNA binding (GO:0003723) 2.364ADAR, IFIH1, SAMHD1, RNASEH2A
protein binding (GO:0005515) 0.464SAMHD1, TREX1, IFIH1, ADAR
endonuclease activity (GO:0004519) 4.783RNASEH2B, RNASEH2C, RNASEH2A
ribonuclease activity (GO:0004540) 5.043RNASEH2B, RNASEH2C, RNASEH2A
endoribonuclease activity (GO:0004521) 5.583RNASEH2B, RNASEH2C, RNASEH2A
RNA-DNA hybrid ribonuclease activity (GO:0004523) 6.743RNASEH2B, RNASEH2C, RNASEH2A
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters (GO:0016893) 5.833RNASEH2B, RNASEH2C, RNASEH2A
endoribonuclease activity, producing 5'-phosphomonoesters (GO:0016891) 6.023RNASEH2B, RNASEH2C, RNASEH2A
DNA binding (GO:0003677) 1.923IFIH1, TREX1, ADAR
transition metal ion binding (GO:0046914) 2.482IFIH1, SAMHD1
carbohydrate derivative binding (GO:0097367) 2.032IFIH1, SAMHD1
nucleotide binding (GO:0000166) 1.962IFIH1, SAMHD1
small molecule binding (GO:0036094) 1.892IFIH1, SAMHD1
macromolecular complex binding (GO:0044877) 2.612IFIH1, TREX1
zinc ion binding (GO:0008270) 2.662IFIH1, SAMHD1
purine nucleotide binding (GO:0017076) 2.192IFIH1, SAMHD1
nucleoside phosphate binding (GO:1901265) 1.962IFIH1, SAMHD1

NET-GE enrichment

Term New enriched termICP valueGenes
hydrolase activity (GO:0016787) -1.90.001SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A
3'-5' exonuclease activity (GO:0008408) NEW5.830.025TREX1, ADAR
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters (GO:0016796) NEW5.890.016TREX1, ADAR
nuclease activity (GO:0004518) -4.330.021RNASEH2B, TREX1, RNASEH2A
ribonuclease activity (GO:0004540) -5.040.024RNASEH2B, RNASEH2A
endoribonuclease activity (GO:0004521) -5.580.009RNASEH2B, RNASEH2A
hydrolase activity, acting on ester bonds (GO:0016788) -3.10.004RNASEH2B, SAMHD1, TREX1, ADAR, RNASEH2A
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters (GO:0016893) -5.830.008RNASEH2B, RNASEH2A
endoribonuclease activity, producing 5'-phosphomonoesters (GO:0016891) -6.020.008RNASEH2B, RNASEH2A
RNA-DNA hybrid ribonuclease activity (GO:0004523) -6.740.001RNASEH2B, RNASEH2A
purine deoxyribonucleotide binding (GO:0032554) NEW8.130.0SAMHD1, TREX1
deoxyribonucleotide binding (GO:0032552) NEW7.950.0SAMHD1, TREX1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
primary metabolic process (GO:0044238) 0.697SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
cellular process (GO:0009987) 0.267SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
metabolic process (GO:0008152) 0.587SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
cellular metabolic process (GO:0044237) 0.697SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
organic substance metabolic process (GO:0071704) 0.637SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
nucleobase-containing compound metabolic process (GO:0006139) 1.356SAMHD1, TREX1, ADAR, RNASEH2B, RNASEH2A, RNASEH2C
cellular macromolecule metabolic process (GO:0044260) 0.936TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
cellular aromatic compound metabolic process (GO:0006725) 1.36SAMHD1, TREX1, ADAR, RNASEH2B, RNASEH2A, RNASEH2C
macromolecule metabolic process (GO:0043170) 0.836TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
cellular nitrogen compound metabolic process (GO:0034641) 1.226SAMHD1, TREX1, ADAR, RNASEH2B, RNASEH2A, RNASEH2C
nitrogen compound metabolic process (GO:0006807) 1.136SAMHD1, TREX1, ADAR, RNASEH2B, RNASEH2A, RNASEH2C
organic cyclic compound metabolic process (GO:1901360) 1.266SAMHD1, TREX1, ADAR, RNASEH2B, RNASEH2A, RNASEH2C
heterocycle metabolic process (GO:0046483) 1.316SAMHD1, TREX1, ADAR, RNASEH2B, RNASEH2A, RNASEH2C
response to stress (GO:0006950) 1.85ADAR, IFIH1, TREX1, SAMHD1, RNASEH2A
nucleic acid metabolic process (GO:0090304) 1.465RNASEH2B, RNASEH2C, TREX1, RNASEH2A, ADAR
response to stimulus (GO:0050896) 1.225SAMHD1, TREX1, ADAR, RNASEH2A, IFIH1
biological regulation (GO:0065007) 0.395RNASEH2B, SAMHD1, TREX1, IFIH1, ADAR
regulation of biological process (GO:0050789) 0.455RNASEH2B, IFIH1, TREX1, SAMHD1, ADAR
RNA metabolic process (GO:0016070) 1.594RNASEH2B, RNASEH2C, RNASEH2A, ADAR
organic substance catabolic process (GO:1901575) 2.454RNASEH2B, SAMHD1, RNASEH2C, RNASEH2A
cellular nitrogen compound catabolic process (GO:0044270) 3.84RNASEH2B, SAMHD1, RNASEH2C, RNASEH2A
regulation of response to stress (GO:0080134) 2.534RNASEH2B, IFIH1, SAMHD1, ADAR
regulation of response to stimulus (GO:0048583) 1.544RNASEH2B, SAMHD1, IFIH1, ADAR
heterocycle catabolic process (GO:0046700) 3.824RNASEH2B, SAMHD1, RNASEH2C, RNASEH2A
cellular catabolic process (GO:0044248) 2.624RNASEH2B, SAMHD1, RNASEH2C, RNASEH2A
nucleic acid phosphodiester bond hydrolysis (GO:0090305) 4.124RNASEH2B, TREX1, RNASEH2C, RNASEH2A
aromatic compound catabolic process (GO:0019439) 3.794RNASEH2B, SAMHD1, RNASEH2C, RNASEH2A
nucleobase-containing compound catabolic process (GO:0034655) 3.94RNASEH2B, SAMHD1, RNASEH2C, RNASEH2A
regulation of cellular process (GO:0050794) 0.54RNASEH2B, SAMHD1, IFIH1, ADAR
catabolic process (GO:0009056) 2.384RNASEH2B, SAMHD1, RNASEH2C, RNASEH2A
organic cyclic compound catabolic process (GO:1901361) 3.734RNASEH2B, SAMHD1, RNASEH2C, RNASEH2A
RNA phosphodiester bond hydrolysis (GO:0090501) 4.833RNASEH2B, RNASEH2C, RNASEH2A
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.153SAMHD1, IFIH1, ADAR
signal transduction (GO:0007165) 1.283IFIH1, SAMHD1, ADAR
single-organism process (GO:0044699) 0.483SAMHD1, RNASEH2B, ADAR
cellular macromolecule catabolic process (GO:0044265) 3.193RNASEH2B, RNASEH2C, RNASEH2A
response to external biotic stimulus (GO:0043207) 3.133IFIH1, SAMHD1, ADAR
response to virus (GO:0009615) 4.213IFIH1, SAMHD1, ADAR
interspecies interaction between organisms (GO:0044419) 3.083SAMHD1, IFIH1, ADAR
regulation of immune system process (GO:0002682) 2.53IFIH1, SAMHD1, ADAR
regulation of defense response (GO:0031347) 3.113SAMHD1, IFIH1, ADAR
positive regulation of biological process (GO:0048518) 1.23IFIH1, RNASEH2B, ADAR
negative regulation of biological process (GO:0048519) 1.333IFIH1, RNASEH2B, ADAR
regulation of innate immune response (GO:0045088) 3.863SAMHD1, IFIH1, ADAR
innate immune response (GO:0045087) 3.553IFIH1, SAMHD1, ADAR
defense response (GO:0006952) 2.783IFIH1, SAMHD1, ADAR
multi-organism cellular process (GO:0044764) 3.143IFIH1, SAMHD1, ADAR
single-organism cellular process (GO:0044763) 0.653SAMHD1, RNASEH2B, ADAR
immune response (GO:0006955) 2.863IFIH1, SAMHD1, ADAR
response to other organism (GO:0051707) 3.483SAMHD1, IFIH1, ADAR
macromolecule catabolic process (GO:0009057) 3.03RNASEH2B, RNASEH2C, RNASEH2A
multi-organism process (GO:0051704) 2.653SAMHD1, IFIH1, ADAR
RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502) 5.413RNASEH2B, RNASEH2C, RNASEH2A
regulation of immune response (GO:0050776) 2.983SAMHD1, IFIH1, ADAR
response to biotic stimulus (GO:0009607) 3.093IFIH1, SAMHD1, ADAR
defense response to virus (GO:0051607) 4.633IFIH1, SAMHD1, ADAR
response to external stimulus (GO:0009605) 2.553SAMHD1, IFIH1, ADAR
immune system process (GO:0002376) 2.293SAMHD1, IFIH1, ADAR
RNA catabolic process (GO:0006401) 4.33RNASEH2B, RNASEH2C, RNASEH2A
viral process (GO:0016032) 3.153SAMHD1, IFIH1, ADAR
immune effector process (GO:0002252) 3.583SAMHD1, IFIH1, ADAR
defense response to other organism (GO:0098542) 3.753IFIH1, SAMHD1, ADAR
cellular component assembly (GO:0022607) 2.142SAMHD1, ADAR
negative regulation of metabolic process (GO:0009892) 1.932RNASEH2B, ADAR
cytokine-mediated signaling pathway (GO:0019221) 3.62SAMHD1, ADAR
regulation of metabolic process (GO:0019222) 1.022RNASEH2B, ADAR
macromolecular complex subunit organization (GO:0043933) 2.142SAMHD1, ADAR
mismatch repair (GO:0006298) 6.232TREX1, RNASEH2A
cellular macromolecule biosynthetic process (GO:0034645) 1.662TREX1, RNASEH2A
cellular biosynthetic process (GO:0044249) 1.372TREX1, RNASEH2A
negative regulation of gene expression (GO:0010629) 2.482RNASEH2B, ADAR
embryo development ending in birth or egg hatching (GO:0009792) 4.352RNASEH2B, ADAR
small molecule metabolic process (GO:0044281) 2.382SAMHD1, RNASEH2B
cell surface receptor signaling pathway (GO:0007166) 2.092SAMHD1, ADAR
multicellular organism development (GO:0007275) 2.542RNASEH2B, ADAR
cellular component organization or biogenesis (GO:0071840) 1.222SAMHD1, ADAR
organic substance biosynthetic process (GO:1901576) 1.342TREX1, RNASEH2A
cellular response to stimulus (GO:0051716) 1.972TREX1, RNASEH2A
in utero embryonic development (GO:0001701) 4.42RNASEH2B, ADAR
negative regulation of macromolecule metabolic process (GO:0010605) 2.012RNASEH2B, ADAR
cellular component organization (GO:0016043) 1.242SAMHD1, ADAR
macromolecular complex assembly (GO:0065003) 2.552SAMHD1, ADAR
DNA replication (GO:0006260) 4.512TREX1, RNASEH2A
chordate embryonic development (GO:0043009) 4.382RNASEH2B, ADAR
regulation of gene expression (GO:0010468) 1.372RNASEH2B, ADAR
developmental process (GO:0032502) 1.362RNASEH2B, ADAR
multicellular organismal process (GO:0032501) 1.452RNASEH2B, ADAR
cellular response to virus (GO:0098586) 6.592IFIH1, ADAR
DNA repair (GO:0006281) 3.592TREX1, RNASEH2A
regulation of macromolecule metabolic process (GO:0060255) 1.082RNASEH2B, ADAR
regulation of type I interferon production (GO:0032479) 5.032IFIH1, TREX1
single-organism metabolic process (GO:0044710) 1.632SAMHD1, RNASEH2B
single-organism developmental process (GO:0044767) 1.492RNASEH2B, ADAR
organophosphate metabolic process (GO:0019637) 3.042SAMHD1, RNASEH2B
macromolecule modification (GO:0043412) 1.732IFIH1, ADAR
macromolecule biosynthetic process (GO:0009059) 1.612TREX1, RNASEH2A
nucleotide metabolic process (GO:0009117) 3.732SAMHD1, RNASEH2B
type I interferon signaling pathway (GO:0060337) 5.592SAMHD1, ADAR
regulation of multicellular organismal process (GO:0051239) 1.872IFIH1, TREX1
nucleobase-containing small molecule metabolic process (GO:0055086) 3.592SAMHD1, RNASEH2B
cellular response to DNA damage stimulus (GO:0006974) 3.172TREX1, RNASEH2A
single-multicellular organism process (GO:0044707) 1.782RNASEH2B, ADAR
embryo development (GO:0009790) 4.22RNASEH2B, ADAR
carbohydrate derivative metabolic process (GO:1901135) 3.072SAMHD1, RNASEH2B
anatomical structure development (GO:0048856) 1.582RNASEH2B, ADAR
biosynthetic process (GO:0009058) 1.322TREX1, RNASEH2A
regulation of cytokine production (GO:0001817) 3.42IFIH1, TREX1
phosphate-containing compound metabolic process (GO:0006796) 2.162SAMHD1, RNASEH2B
cellular response to stress (GO:0033554) 2.512TREX1, RNASEH2A
phosphorus metabolic process (GO:0006793) 2.152SAMHD1, RNASEH2B
DNA metabolic process (GO:0006259) 3.092TREX1, RNASEH2A
nucleoside phosphate metabolic process (GO:0006753) 3.712SAMHD1, RNASEH2B
positive regulation of cellular process (GO:0048522) 1.32RNASEH2B, ADAR

NET-GE enrichment

Term New enriched termICP valueGenes
cellular macromolecule catabolic process (GO:0044265) -3.190.033RNASEH2B, RNASEH2C, TREX1, RNASEH2A, ADAR
cellular nitrogen compound catabolic process (GO:0044270) -3.80.0SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
response to virus (GO:0009615) -4.210.025IFIH1, SAMHD1, ADAR
innate immune response (GO:0045087) -3.550.031SAMHD1, TREX1, IFIH1, ADAR
mismatch repair (GO:0006298) -6.230.038TREX1, RNASEH2A
heterocycle catabolic process (GO:0046700) -3.820.003SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
cellular catabolic process (GO:0044248) -2.620.049RNASEH2B, SAMHD1, TREX1, RNASEH2C, RNASEH2A
nucleic acid phosphodiester bond hydrolysis (GO:0090305) -4.120.024RNASEH2B, TREX1, RNASEH2A
RNA catabolic process (GO:0006401) -4.30.016RNASEH2B, RNASEH2C, RNASEH2A
aromatic compound catabolic process (GO:0019439) -3.790.0SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
nucleobase-containing compound catabolic process (GO:0034655) -3.90.0SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
macromolecule catabolic process (GO:0009057) -3.00.004TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
organic cyclic compound catabolic process (GO:1901361) -3.730.003RNASEH2B, SAMHD1, TREX1, RNASEH2C, RNASEH2A
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.67SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
nucleus (GO:0005634) 1.077SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
cell part (GO:0044464) 0.117SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
intracellular organelle (GO:0043229) 0.517SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
intracellular part (GO:0044424) 0.287SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
membrane-bounded organelle (GO:0043227) 0.477SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
organelle (GO:0043226) 0.47SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
cytoplasm (GO:0005737) 1.014IFIH1, TREX1, RNASEH2A, ADAR
intracellular organelle part (GO:0044446) 0.814SAMHD1, TREX1, RNASEH2A, ADAR
nuclear part (GO:0044428) 1.554SAMHD1, TREX1, ADAR, RNASEH2A
macromolecular complex (GO:0032991) 1.354RNASEH2B, RNASEH2C, RNASEH2A, ADAR
organelle part (GO:0044422) 0.794SAMHD1, TREX1, ADAR, RNASEH2A
nucleoplasm (GO:0005654) 1.893SAMHD1, ADAR, RNASEH2A
protein complex (GO:0043234) 1.513RNASEH2B, RNASEH2C, RNASEH2A
membrane (GO:0016020) 0.683SAMHD1, TREX1, ADAR
ribonuclease H2 complex (GO:0032299) 8.73RNASEH2B, RNASEH2C, RNASEH2A
cytosol (GO:0005829) 1.682IFIH1, TREX1
cytoplasmic part (GO:0044444) 0.822IFIH1, TREX1

NET-GE enrichment

Term New enriched termICP valueGenes
nucleus (GO:0005634) -1.070.009SAMHD1, TREX1, ADAR, IFIH1, RNASEH2B, RNASEH2A, RNASEH2C
ribonuclease H2 complex (GO:0032299) -8.70.0RNASEH2B, RNASEH2C, RNASEH2A