Disease table of ESOPHAGEAL CANCER OMIM ID: 133239

Gene-disease associations table

GeneAssociated with ESOPHAGEAL CANCER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TGFBR2OMIM, HUMSAVARHGNC link3p24.14133239, PS120435, PS607086, PS609192
DCCOMIMHGNC link18q21.23133239, PS157600, 114500
DLEC1OMIMHGNC link3p22.22133239, 211980
WWOXOMIMHGNC link16q23.13133239, 614322, PS308350
RNF6OMIMHGNC link13q12.131133239
DEC1OMIMHGNC link9q33.11133239
LZTS1OMIMHGNC link8p21.31133239

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
3p22TGFBR2, DLEC1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
3p2TGFBR2, DLEC1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
32TGFBR2, DLEC1
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TGFBR2YES5SP1, ETV4, ETS1, FLI1, EGR10
DCCYES1SOX90
WWOXYES1E2F10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
DCCRNF6No1AR
WWOXDEC1No4CSNK2A2, CSNK2A1, PPP1CA, NONO
WWOXLZTS1No1LZTS2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TGFBR2DCCNo-1RHOA
TGFBR2WWOXNo-4UBC, YAP1, SMAD3, SMAD4
DCCWWOXNo-3SRC, MAP2K1, EZR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Colorectal cancerhsa052106.522DCC, TGFBR2
Pathways in cancerhsa052003.982DCC, TGFBR2

NET-GE enrichment

Term New enriched termICP valueGenes
Colorectal cancer (hsa05210) -6.520.004DCC, TGFBR2
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.782WWOX, TGFBR2
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185DCC, WWOX, LZTS1, TGFBR2, RNF6
protein binding (GO:0005515) 0.465DCC, WWOX, LZTS1, TGFBR2, RNF6
catalytic activity (GO:0003824) 1.053WWOX, TGFBR2, RNF6
heterocyclic compound binding (GO:1901363) 1.063LZTS1, TGFBR2, RNF6
organic cyclic compound binding (GO:0097159) 1.053LZTS1, TGFBR2, RNF6
cation binding (GO:0043169) 1.42TGFBR2, RNF6
signaling receptor activity (GO:0038023) 2.492DCC, TGFBR2
signal transducer activity (GO:0004871) 2.282DCC, TGFBR2
transmembrane signaling receptor activity (GO:0004888) 2.572DCC, TGFBR2
enzyme binding (GO:0019899) 2.272WWOX, TGFBR2
ion binding (GO:0043167) 1.362TGFBR2, RNF6
molecular transducer activity (GO:0060089) 2.322DCC, TGFBR2
transferase activity (GO:0016740) 1.952TGFBR2, RNF6
receptor activity (GO:0004872) 2.322DCC, TGFBR2
nucleic acid binding (GO:0003676) 1.442LZTS1, RNF6
DNA binding (GO:0003677) 1.922LZTS1, RNF6
receptor binding (GO:0005102) 2.432TGFBR2, RNF6
metal ion binding (GO:0046872) 1.412TGFBR2, RNF6
transmembrane receptor activity (GO:0099600) 2.532DCC, TGFBR2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
negative regulation of biological process (GO:0048519) 1.337WWOX, DLEC1, LZTS1, TGFBR2, DCC, DEC1, RNF6
biological regulation (GO:0065007) 0.397WWOX, DLEC1, LZTS1, TGFBR2, DCC, DEC1, RNF6
regulation of biological process (GO:0050789) 0.457WWOX, DLEC1, LZTS1, TGFBR2, DCC, DEC1, RNF6
negative regulation of cellular process (GO:0048523) 1.417WWOX, DLEC1, LZTS1, TGFBR2, DCC, DEC1, RNF6
regulation of cellular process (GO:0050794) 0.57WWOX, DLEC1, LZTS1, TGFBR2, DCC, DEC1, RNF6
cellular process (GO:0009987) 0.265DCC, WWOX, LZTS1, TGFBR2, RNF6
regulation of cell morphogenesis (GO:0022604) 3.44DCC, LZTS1, TGFBR2, RNF6
primary metabolic process (GO:0044238) 0.694WWOX, LZTS1, TGFBR2, RNF6
regulation of primary metabolic process (GO:0080090) 1.084WWOX, LZTS1, TGFBR2, RNF6
regulation of metabolic process (GO:0019222) 1.024WWOX, LZTS1, TGFBR2, RNF6
regulation of anatomical structure morphogenesis (GO:0022603) 2.794DCC, LZTS1, TGFBR2, RNF6
regulation of developmental process (GO:0050793) 2.14DCC, LZTS1, TGFBR2, RNF6
regulation of cellular metabolic process (GO:0031323) 1.074WWOX, LZTS1, TGFBR2, RNF6
regulation of cell development (GO:0060284) 3.014DCC, LZTS1, TGFBR2, RNF6
regulation of cellular component organization (GO:0051128) 2.014DCC, LZTS1, TGFBR2, RNF6
metabolic process (GO:0008152) 0.584WWOX, LZTS1, TGFBR2, RNF6
organic substance metabolic process (GO:0071704) 0.634WWOX, LZTS1, TGFBR2, RNF6
regulation of cell differentiation (GO:0045595) 2.424DCC, LZTS1, TGFBR2, RNF6
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.914DCC, LZTS1, TGFBR2, RNF6
regulation of multicellular organismal development (GO:2000026) 2.314DCC, LZTS1, TGFBR2, RNF6
regulation of multicellular organismal process (GO:0051239) 1.874DCC, LZTS1, TGFBR2, RNF6
regulation of signaling (GO:0023051) 1.724WWOX, LZTS1, TGFBR2, RNF6
regulation of macromolecule metabolic process (GO:0060255) 1.084WWOX, LZTS1, TGFBR2, RNF6
single-organism cellular process (GO:0044763) 0.654DCC, WWOX, LZTS1, TGFBR2
regulation of cell communication (GO:0010646) 1.734WWOX, LZTS1, TGFBR2, RNF6
regulation of gene expression (GO:0010468) 1.374WWOX, LZTS1, TGFBR2, RNF6
single-organism process (GO:0044699) 0.484DCC, WWOX, LZTS1, TGFBR2
regulation of developmental growth (GO:0048638) 4.043DCC, TGFBR2, RNF6
negative regulation of growth (GO:0045926) 4.243DCC, TGFBR2, RNF6
positive regulation of metabolic process (GO:0009893) 1.743WWOX, TGFBR2, RNF6
regulation of cellular biosynthetic process (GO:0031326) 1.383WWOX, LZTS1, RNF6
positive regulation of cellular metabolic process (GO:0031325) 1.813WWOX, TGFBR2, RNF6
regulation of response to stimulus (GO:0048583) 1.543WWOX, TGFBR2, RNF6
signal transduction (GO:0007165) 1.283DCC, WWOX, TGFBR2
cell surface receptor signaling pathway (GO:0007166) 2.093DCC, WWOX, TGFBR2
cell death (GO:0008219) 3.053DCC, WWOX, TGFBR2
anatomical structure morphogenesis (GO:0009653) 2.533DCC, WWOX, TGFBR2
regulation of cell projection organization (GO:0031344) 3.383DCC, LZTS1, RNF6
regulation of neurogenesis (GO:0050767) 3.213DCC, LZTS1, RNF6
positive regulation of macromolecule metabolic process (GO:0010604) 1.813WWOX, TGFBR2, RNF6
cellular macromolecule metabolic process (GO:0044260) 0.933LZTS1, TGFBR2, RNF6
regulation of signal transduction (GO:0009966) 1.843WWOX, TGFBR2, RNF6
cellular developmental process (GO:0048869) 1.823DCC, WWOX, TGFBR2
regulation of growth (GO:0040008) 3.263DCC, TGFBR2, RNF6
negative regulation of multicellular organismal process (GO:0051241) 2.843DCC, TGFBR2, RNF6
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463WWOX, LZTS1, RNF6
regulation of neuron differentiation (GO:0045664) 3.393DCC, LZTS1, RNF6
regulation of macromolecule biosynthetic process (GO:0010556) 1.433WWOX, LZTS1, RNF6
positive regulation of biological process (GO:0048518) 1.23WWOX, TGFBR2, RNF6
regulation of cell proliferation (GO:0042127) 2.413DLEC1, DEC1, TGFBR2
negative regulation of cell proliferation (GO:0008285) 3.263DLEC1, DEC1, TGFBR2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433WWOX, LZTS1, RNF6
apoptotic process (GO:0006915) 3.143DCC, WWOX, TGFBR2
regulation of biosynthetic process (GO:0009889) 1.373WWOX, LZTS1, RNF6
regulation of nucleic acid-templated transcription (GO:1903506) 1.553WWOX, LZTS1, RNF6
single-organism developmental process (GO:0044767) 1.493DCC, WWOX, TGFBR2
negative regulation of developmental growth (GO:0048640) 5.253DCC, TGFBR2, RNF6
regulation of nitrogen compound metabolic process (GO:0051171) 1.363WWOX, LZTS1, RNF6
regulation of neuron projection development (GO:0010975) 3.693DCC, LZTS1, RNF6
regulation of RNA biosynthetic process (GO:2001141) 1.553WWOX, LZTS1, RNF6
negative regulation of developmental process (GO:0051093) 3.173DCC, TGFBR2, RNF6
programmed cell death (GO:0012501) 3.13DCC, WWOX, TGFBR2
regulation of RNA metabolic process (GO:0051252) 1.523WWOX, LZTS1, RNF6
cellular metabolic process (GO:0044237) 0.693LZTS1, TGFBR2, RNF6
macromolecule metabolic process (GO:0043170) 0.833LZTS1, TGFBR2, RNF6
developmental process (GO:0032502) 1.363DCC, WWOX, TGFBR2
regulation of transcription, DNA-templated (GO:0006355) 1.563WWOX, LZTS1, RNF6
regulation of nervous system development (GO:0051960) 3.13DCC, LZTS1, RNF6
positive regulation of cellular process (GO:0048522) 1.33WWOX, TGFBR2, RNF6
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562WWOX, RNF6
negative regulation of cell growth (GO:0030308) 4.582DCC, RNF6
positive regulation of biosynthetic process (GO:0009891) 2.292WWOX, RNF6
negative regulation of response to stimulus (GO:0048585) 2.522WWOX, TGFBR2
positive regulation of response to stimulus (GO:0048584) 2.182WWOX, TGFBR2
apoptotic signaling pathway (GO:0097190) 4.122DCC, WWOX
extrinsic apoptotic signaling pathway (GO:0097191) 5.162DCC, WWOX
negative regulation of cellular component organization (GO:0051129) 3.352DCC, RNF6
negative regulation of signaling (GO:0023057) 2.652WWOX, TGFBR2
multicellular organismal process (GO:0032501) 1.452DCC, TGFBR2
positive regulation of gene expression (GO:0010628) 2.352WWOX, RNF6
negative regulation of cell communication (GO:0010648) 2.662WWOX, TGFBR2
regulation of extent of cell growth (GO:0061387) 5.092DCC, RNF6
negative regulation of cell projection organization (GO:0031345) 4.722DCC, RNF6
multicellular organism development (GO:0007275) 2.542DCC, TGFBR2
organic cyclic compound metabolic process (GO:1901360) 1.262WWOX, LZTS1
response to endogenous stimulus (GO:0009719) 2.792WWOX, TGFBR2
cellular protein metabolic process (GO:0044267) 1.632TGFBR2, RNF6
single-organism metabolic process (GO:0044710) 1.632WWOX, TGFBR2
regulation of cell death (GO:0010941) 2.432DCC, WWOX
regulation of dendrite development (GO:0050773) 4.932DCC, LZTS1
negative regulation of signal transduction (GO:0009968) 2.752WWOX, TGFBR2
positive regulation of cellular biosynthetic process (GO:0031328) 2.32WWOX, RNF6
negative regulation of nervous system development (GO:0051961) 4.152DCC, RNF6
negative regulation of neurogenesis (GO:0050768) 4.222DCC, RNF6
negative regulation of neuron differentiation (GO:0045665) 4.452DCC, RNF6
negative regulation of cell development (GO:0010721) 4.022DCC, RNF6
skeletal system morphogenesis (GO:0048705) 4.982WWOX, TGFBR2
organ morphogenesis (GO:0009887) 3.552WWOX, TGFBR2
cell differentiation (GO:0030154) 2.142WWOX, TGFBR2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352WWOX, RNF6
cellular protein modification process (GO:0006464) 1.792TGFBR2, RNF6
negative regulation of cell differentiation (GO:0045596) 3.332DCC, RNF6
macromolecule modification (GO:0043412) 1.732TGFBR2, RNF6
regulation of cell growth (GO:0001558) 3.752DCC, RNF6
negative regulation of neuron projection development (GO:0010977) 4.882DCC, RNF6
positive regulation of transcription, DNA-templated (GO:0045893) 2.562WWOX, RNF6
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292WWOX, RNF6
response to chemical (GO:0042221) 1.982WWOX, TGFBR2
response to organic substance (GO:0010033) 2.22WWOX, TGFBR2
negative regulation of axonogenesis (GO:0050771) 5.522DCC, RNF6
regulation of axonogenesis (GO:0050770) 4.592DCC, RNF6
single-multicellular organism process (GO:0044707) 1.782DCC, TGFBR2
protein metabolic process (GO:0019538) 1.452TGFBR2, RNF6
response to stimulus (GO:0050896) 1.222WWOX, TGFBR2
anatomical structure development (GO:0048856) 1.582DCC, TGFBR2
positive regulation of RNA metabolic process (GO:0051254) 2.512WWOX, RNF6
positive regulation of RNA biosynthetic process (GO:1902680) 2.542WWOX, RNF6
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392WWOX, RNF6
protein modification process (GO:0036211) 1.792TGFBR2, RNF6
negative regulation of cell morphogenesis involved in differentiation (GO:0010771) 4.962DCC, RNF6

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of developmental growth (GO:0048638) -4.040.006DCC, TGFBR2, RNF6
negative regulation of cell growth (GO:0030308) -4.580.021DCC, WWOX, TGFBR2, RNF6
regulation of anatomical structure morphogenesis (GO:0022603) -2.790.035DCC, LZTS1, TGFBR2, RNF6
regulation of cell morphogenesis involved in differentiation (GO:0010769) -3.910.037DCC, LZTS1, RNF6
negative regulation of developmental growth (GO:0048640) -5.250.033DCC, RNF6
negative regulation of biological process (GO:0048519) -1.330.006WWOX, DLEC1, LZTS1, TGFBR2, DCC, DEC1, RNF6
negative regulation of cellular process (GO:0048523) -1.410.003WWOX, DLEC1, LZTS1, TGFBR2, DCC, DEC1, RNF6
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.286WWOX, DLEC1, LZTS1, TGFBR2, DCC, RNF6
cell part (GO:0044464) 0.116WWOX, DLEC1, LZTS1, TGFBR2, DCC, RNF6
cytoplasm (GO:0005737) 1.015DLEC1, WWOX, LZTS1, TGFBR2, RNF6
membrane (GO:0016020) 0.685DCC, WWOX, LZTS1, TGFBR2, RNF6
cell projection (GO:0042995) 2.474DCC, WWOX, LZTS1, RNF6
plasma membrane (GO:0005886) 1.394DCC, WWOX, LZTS1, TGFBR2
cytosol (GO:0005829) 1.683DCC, WWOX, TGFBR2
intracellular organelle (GO:0043229) 0.513WWOX, LZTS1, RNF6
neuron part (GO:0097458) 2.643DCC, LZTS1, RNF6
cytoplasmic part (GO:0044444) 0.823DCC, WWOX, TGFBR2
neuron projection (GO:0043005) 3.123DCC, LZTS1, RNF6
membrane part (GO:0044425) 0.953DCC, LZTS1, TGFBR2
organelle (GO:0043226) 0.43WWOX, LZTS1, RNF6
protein complex (GO:0043234) 1.512WWOX, TGFBR2
plasma membrane region (GO:0098590) 2.972LZTS1, TGFBR2
macromolecular complex (GO:0032991) 1.352WWOX, TGFBR2
intracellular membrane-bounded organelle (GO:0043231) 0.62WWOX, RNF6
membrane-bounded organelle (GO:0043227) 0.472WWOX, RNF6
integral component of membrane (GO:0016021) 1.142DCC, TGFBR2
axon (GO:0030424) 4.152DCC, RNF6
intracellular organelle part (GO:0044446) 0.812WWOX, RNF6
nuclear part (GO:0044428) 1.552WWOX, RNF6
organelle part (GO:0044422) 0.792WWOX, RNF6
plasma membrane part (GO:0044459) 1.952LZTS1, TGFBR2
nucleus (GO:0005634) 1.072WWOX, RNF6
intrinsic component of membrane (GO:0031224) 1.132DCC, TGFBR2

NET-GE enrichment

Term New enriched termICP valueGenes
cell projection (GO:0042995) -2.470.033DCC, WWOX, LZTS1, TGFBR2, RNF6
neuron projection (GO:0043005) -3.120.03DCC, LZTS1, RNF6
membrane raft (GO:0045121) NEW4.180.041DCC, WWOX, TGFBR2