Disease table of COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS OMIM ID: PS120435

Gene-disease associations table

Gene	Associated with COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TGFBR2	ClinVar, OMIM, HUMSAVAR	HGNC link	3p24.1	4	133239, PS120435, PS607086, PS609192
MSH2	ClinVar, OMIM, HUMSAVAR	HGNC link	2p21	3	276300, 158320, PS120435
MLH3	ClinVar, OMIM, HUMSAVAR	HGNC link	14q24.3	3	114500, 608089, PS120435
MSH6	ClinVar, OMIM, HUMSAVAR	HGNC link	2p16.3	3	276300, PS120435, 608089
MLH1	ClinVar, OMIM, HUMSAVAR	HGNC link	3p22.2	3	276300, 158320, PS120435
EPCAM	OMIM	HGNC link	2p21	2	PS120435, PS214700
PMS2	ClinVar, OMIM, HUMSAVAR	HGNC link	7p22.1	2	276300, PS120435

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
2p21	2	MSH2, EPCAM

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
2p21	2	MSH2, EPCAM

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
3p2	2	TGFBR2, MLH1
2p2	2	MSH2, EPCAM

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
3p	2	TGFBR2, MLH1
2p	3	MSH6, MSH2, EPCAM

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
3	2	TGFBR2, MLH1
2	3	MSH6, MSH2, EPCAM

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
DNMT1	NO	24	MBD2, BIRC5, IL32, CDKN2A, CDKN2B, TIMP3, CASP8, PROM1, CXCR4, BAG1, TERT, GAD1, TNFRSF10B, CDH1, VEGFA, RELN, EPCAM, MGMT, IL3, KIR2DL3, RUNX3, RB1, BMP2, MSH2	2	EPCAM, MSH2

regulated gene	associated to this disease	# TFs	TFs
TGFBR2	YES	5	SP1, ETV4, ETS1, FLI1, EGR1
MSH2	YES	2	MBD2, DNMT1
MSH6	YES	1	SP3
MLH1	YES	1	CEBPZ
EPCAM	YES	5	DNMT1, HDAC1, NFKB1, ZEB1, RELA

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TGFBR2	MLH1	No	1	AP2B1
MSH2	MLH3	No	2	MYC, MLH1
MSH2	MSH6	Yes	45	ATM, AIRE, FAF2, RAD9A, PRKCZ, XRCC6, TP53, DTL, RAD50, SIRT7, SMARCAD1, SNW1, ATR, CDC5L, FEN1, MSH2, BLM, RFC1, PMS1, PMS2, BRCA1, RAD21, MRE11A, NBN, ATP6V1B2, RAD1, CEP19, MUTYH, BARD1, RNF126, SUPT16H, RAD51, PCNA, SLX4, SIRT6, CREBBP, MSH3, SUPT5H, CHEK1, HUS1, XRCC5, NTRK1, MYC, MLH1, POLK
MSH2	MLH1	Yes	20	ATM, NBN, MSH3, PCNA, MYC, MRE11A, BARD1, PMS1, RFC1, MSH6, BLM, RAD50, PMS2, EXO1, NTRK1, SNW1, BRCA1, ANXA6, MSH2, FANCD2
MSH2	PMS2	Yes	7	MSH6, MSH3, PCNA, MSH2, EXO1, BRCA1, MLH1
MLH3	MSH6	No	2	MYC, MLH1
MLH3	MLH1	Yes	3	MYC, MSH4, FAN1
MLH3	PMS2	No	2	MLH1, FAN1
MSH6	MLH1	Yes	18	ATM, NBN, MSH3, PRKDC, MSH2, BARD1, PMS1, RFC1, MYC, BLM, PMS2, MRE11A, SMC1A, PCNA, NTRK1, RAD50, SNW1, BRCA1
MSH6	PMS2	Yes	8	MSH3, CLSPN, MSH2, PRKDC, TOPBP1, PCNA, BRCA1, MLH1
MLH1	PMS2	Yes	20	MSH3, ATAD3A, PCNA, PIK3C2A, MMS19, BRIP1, MSH2, PRKDC, RUVBL1, PSD3, RUVBL2, FAN1, EXO1, UBC, KPNA2, BRCA1, KPNB1, MSH6, SPRTN, AIFM1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
TGFBR2	MSH2	No	-	4	TGFB1, UBC, UBB, HSP90AA1
TGFBR2	MSH6	No	-	1	UBC
TGFBR2	EPCAM	No	-	1	CCND1
TGFBR2	PMS2	No	-	1	UBC
MSH2	MLH3	Yes	binding	17	ERCC1, POLD1, MSH3, PCNA, WRN, MLH1, RPA1, PMS1, ERCC4, BLM, POLE, DMC1, PMS2, EXO1, MSH6, RECQL, RAD51
MSH2	MSH6	Yes	binding	44	ERCC5, POLE4, PCNA, CHEK1, POLE3, TP53, FANCM, RAD50, XPC, ERCC8, POLD1, ATR, RAD52, POLE, MLH1, RAD51, PMS1, SWSAP1, RECQL, BRCA1, RAD51D, ERCC1, RAD23B, MUTYH, BARD1, PMS2, ZSWIM7, ALDH18A1, XRCC6BP1, EXO1, RAD51B, CHRAC1, MSH3, XRCC5, WRN, XRCC4, XRCC6, ERCC4, BLM, MLH3, OGG1, UBC, POLE2, POLK
MSH2	MLH1	Yes	binding	31	ERCC5, PCNA, RAD9A, FANCD2, TP53, RAD50, XPC, XPA, POLD1, POLE, RAD51, RPA1, PMS1, RAD23B, BRCA1, ERCC1, DMC1, PMS2, WDTC1, EXO1, MSH6, RECQL, MSH3, FEN1, WRN, XRCC6, ERCC4, BLM, XRCC5, MYC, MLH3
MSH2	EPCAM	No	-	2	MYC, TP53
MSH2	PMS2	Yes	binding	21	ERCC1, ERCC5, MSH3, FEN1, POLE, XPC, MLH1, XRCC6, RAD51, ERCC4, TP53, XPA, MLH3, EXO1, RECQL, UBC, MSH6, PCNA, WRN, XRCC5, POLD1
MLH3	MSH6	Yes	binding	15	ERCC1, POLD1, MSH3, PCNA, WRN, MSH2, PMS1, ERCC4, BLM, POLE, PMS2, EXO1, RECQL, MLH1, RAD51
MLH3	MLH1	Yes	binding	27	FBXO18, EXO1, CDK4, MSH4, RPA3, TOP3A, POLD1, POLE, MSH2, RPA1, PMS1, RPA2, RECQL, ERCC1, DMC1, PMS2, PCNA, MSH6, MSH3, BRCA2, CDK2, WRN, MUS81, ERCC4, BLM, RAD51, RAD51C
MLH3	PMS2	Yes	binding	15	ERCC1, POLD1, FBXO18, POLE, WRN, MLH1, MSH3, MSH4, ERCC4, PCNA, RECQL, EXO1, MSH6, MSH2, RAD51
MSH6	MLH1	Yes	binding	23	ERCC5, PCNA, TP53, RAD50, POLD1, POLE, MSH2, PMS1, RAD23B, RECQL, ERCC1, PMS2, EXO1, XPC, BRCA1, MSH3, XRCC5, WRN, XRCC6, ERCC4, BLM, MLH3, RAD51
MSH6	EPCAM	No	-	1	TP53
MSH6	PMS2	Yes	binding	19	POLD1, ERCC1, MSH3, PCNA, WRN, MSH2, XRCC6, TP53, ERCC5, XRCC5, POLE, RAD51, EXO1, UBC, RECQL, ERCC4, MLH1, MLH3, XPC
MLH1	EPCAM	No	-	2	MYC, TP53
MLH1	PMS2	Yes	binding	24	ERCC5, FBXO18, EXO1, TP53, XPC, XPA, POLD1, FEN1, MSH2, RAD51, MSH4, RECQL, ERCC1, PCNA, MSH6, BRIP1, FAN1, MSH3, POLE, WRN, XRCC6, ERCC4, XRCC5, MLH3
EPCAM	PMS2	No	-	1	TP53

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
MSH2	MSH6	Yes	MSH2-MSH6-PMS2-MLH1 complex;MSH2-MSH6-PMS1-MLH1 complex;BASC (Ab 80) complex (BRCA1-associated genome surveillance complex);PCNA-MutS-alpha-DNA initial complex;GCN5-TRRAP histone acetyltransferase complex;MutS-alpha-PK-zeta complex;PCNA-MSH2-MSH6 complex;BASC complex (BRCA1-associated genome surveillance complex);MutS-alpha complex;MSH2/6-BLM-p53-RAD51 complex;PCNA-MutS-alpha-MutL-alpha-DNA complex;MSH2-MSH6 complex	23	ATM, KAT2A, TAF10, TAF5L, TP53, TRRAP, RAD50, SUPT3H, MLH1, RFC1, PMS1, BRCA1, NBN, TADA3, MRE11A, PCNA, RFC2, PMS2, PRKCZ, TAF9, BLM, RFC4, RAD51
MSH2	MLH1	Yes	MSH2-MSH6-PMS2-MLH1 complex;MSH2-MSH6-PMS1-MLH1 complex;BASC (Ab 80) complex (BRCA1-associated genome surveillance complex);MSH2-MLH1-PMS2 DNA-repair initiation complex;MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex;BASC complex (BRCA1-associated genome surveillance complex);PCNA-MutS-alpha-MutL-alpha-DNA complex	13	ATM, NBN, PMS2, RFC2, PCNA, MRE11A, PMS1, RFC1, BLM, RAD50, RFC4, BRCA1, MSH6
MSH2	PMS2	Yes	MSH2-MSH6-PMS2-MLH1 complex;MSH2-MLH1-PMS2 DNA-repair initiation complex;PCNA-MutS-alpha-MutL-alpha-DNA complex;MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex	3	MSH6, MLH1, PCNA
MSH6	MLH1	Yes	MSH2-MSH6-PMS2-MLH1 complex;MSH2-MSH6-PMS1-MLH1 complex;BASC (Ab 80) complex (BRCA1-associated genome surveillance complex);BASC complex (BRCA1-associated genome surveillance complex);BRCA1-BARD1-BACH1-DNA damage complex I;PCNA-MutS-alpha-MutL-alpha-DNA complex	16	ATM, NBN, TOPBP1, RFC2, PCNA, BACH1, MRE11A, BARD1, PMS1, RFC1, BLM, RAD50, PMS2, RFC4, BRCA1, MSH2
MSH6	PMS2	Yes	MSH2-MSH6-PMS2-MLH1 complex;PCNA-MutS-alpha-MutL-alpha-DNA complex	3	MSH2, MLH1, PCNA
MLH1	PMS2	Yes	MSH2-MSH6-PMS2-MLH1 complex;MSH2-MLH1-PMS2 DNA-repair initiation complex;EXO1-MLH1-PMS2 complex;MSH2-MLH1-PMS2-PCNA DNA-repair initiation complex;MutL-alpha complex;PCNA-MutS-alpha-MutL-alpha-DNA complex	4	MSH6, MSH2, EXO1, PCNA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
MSH2	MSH6	Yes	2	MSH3, SUPT16H
MLH1	PMS2	Yes	0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
MSH2	MSH6	Yes	2	MSH2, MSH6

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Mismatch repair	hsa03430	8.07	5	MSH6, PMS2, MSH2, MLH3, MLH1
Colorectal cancer	hsa05210	6.52	4	MSH2, MSH6, TGFBR2, MLH1
Pathways in cancer	hsa05200	3.98	4	MSH2, MSH6, TGFBR2, MLH1
Fanconi anemia pathway	hsa03460	7.01	2	PMS2, MLH1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Cancers: Specific types	NEW	4.1	0.005	MSH6, MSH2, MLH1, TGFBR2
Genetic Information Processing	NEW	2.48	0.032	MSH6, PMS2, MSH2, MLH3, MLH1
Colorectal cancer (hsa05210)	-	6.52	0.0	MSH2, MSH6, TGFBR2, MLH1
Pathways in cancer (hsa05200)	-	3.98	0.007	MSH2, MSH6, TGFBR2, MLH1
Mismatch repair (hsa03430)	-	8.07	0.0	MSH6, PMS2, MSH2, MLH3, MLH1
Replication and repair	NEW	5.41	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
Fanconi anemia pathway (hsa03460)	-	7.01	0.0	MSH6, MSH2, PMS2, MLH1

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	R-HSA-5358565	9.18	4	MSH6, MSH2, PMS2, MLH1
DNA Repair	R-HSA-73894	5.8	4	MSH6, MSH2, PMS2, MLH1
Mismatch Repair	R-HSA-5358508	9.08	4	MSH6, MSH2, PMS2, MLH1
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)	R-HSA-5358606	9.18	3	MSH2, PMS2, MLH1
Cell Cycle	R-HSA-1640170	3.89	2	MLH1, MLH3
Meiosis	R-HSA-1500620	6.59	2	MLH1, MLH3
Meiotic recombination	R-HSA-912446	7.25	2	MLH1, MLH3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) (R-HSA-5358606)	-	9.18	0.0	MSH2, PMS2, MLH1
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) (R-HSA-5358565)	-	9.18	0.0	MSH6, PMS2, MSH2, MLH1
Meiotic recombination (R-HSA-912446)	-	7.25	0.016	MLH1, MLH3
Meiosis (R-HSA-1500620)	-	6.59	0.039	MLH1, MLH3
Mismatch Repair (R-HSA-5358508)	-	9.08	0.0	MSH6, MSH2, PMS2, MLH1
DNA Repair (R-HSA-73894)	-	5.8	0.0	MSH6, MSH2, PMS2, MLH1

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	7	EPCAM, PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
protein binding (GO:0005515)	0.46	7	EPCAM, PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
adenyl ribonucleotide binding (GO:0032559)	2.41	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
ribonucleotide binding (GO:0032553)	2.19	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
carbohydrate derivative binding (GO:0097367)	2.03	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
organic cyclic compound binding (GO:0097159)	1.05	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
adenyl nucleotide binding (GO:0030554)	2.4	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
nucleotide binding (GO:0000166)	1.96	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
small molecule binding (GO:0036094)	1.89	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
catalytic activity (GO:0003824)	1.05	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
purine ribonucleoside binding (GO:0032550)	2.22	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
macromolecular complex binding (GO:0044877)	2.61	6	EPCAM, PMS2, MSH2, MSH6, MLH1, MLH3
ATP binding (GO:0005524)	2.43	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
purine nucleoside binding (GO:0001883)	2.22	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
ribonucleoside binding (GO:0032549)	2.22	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
purine ribonucleotide binding (GO:0032555)	2.2	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
purine nucleotide binding (GO:0017076)	2.19	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
heterocyclic compound binding (GO:1901363)	1.06	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
nucleoside phosphate binding (GO:1901265)	1.96	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
nucleoside binding (GO:0001882)	2.21	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
hydrolase activity (GO:0016787)	1.9	5	MSH6, PMS2, MSH2, MLH3, MLH1
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	5	MSH6, PMS2, MSH2, MLH3, MLH1
ATPase activity (GO:0016887)	3.65	5	MSH6, PMS2, MSH2, MLH3, MLH1
nucleoside-triphosphatase activity (GO:0017111)	3.09	5	MSH6, MSH2, PMS2, MLH3, MLH1
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	5	MSH6, PMS2, MSH2, MLH3, MLH1
mismatched DNA binding (GO:0030983)	7.25	5	MSH6, MSH2, PMS2, MLH3, MLH1
pyrophosphatase activity (GO:0016462)	3.04	5	MSH6, PMS2, MSH2, MLH3, MLH1
nucleic acid binding (GO:0003676)	1.44	5	MSH6, MSH2, PMS2, MLH3, MLH1
DNA binding (GO:0003677)	1.92	5	MSH6, MSH2, PMS2, MLH3, MLH1
protein complex binding (GO:0032403)	3.09	5	EPCAM, MSH6, MSH2, PMS2, MLH1
double-stranded DNA binding (GO:0003690)	3.09	5	MSH6, PMS2, MSH2, MLH3, MLH1
single-stranded DNA binding (GO:0003697)	5.17	4	MSH2, PMS2, MLH3, MLH1
mismatch repair complex binding (GO:0032404)	7.66	4	MSH6, MSH2, PMS2, MLH1
cation binding (GO:0043169)	1.4	3	MSH2, MSH6, TGFBR2
chromatin binding (GO:0003682)	3.64	3	MLH1, MSH6, MLH3
ion binding (GO:0043167)	1.36	3	MSH2, MSH6, TGFBR2
single base insertion or deletion binding (GO:0032138)	8.35	3	MSH6, PMS2, MSH2
guanine/thymine mispair binding (GO:0032137)	8.35	3	MSH2, MSH6, MLH1
DNA insertion or deletion binding (GO:0032135)	7.95	3	MSH6, PMS2, MSH2
metal ion binding (GO:0046872)	1.41	3	MSH2, MSH6, TGFBR2
oxidized purine DNA binding (GO:0032357)	8.13	2	MSH2, MSH6
sequence-specific DNA binding (GO:0043565)	2.79	2	MSH2, MLH3
four-way junction DNA binding (GO:0000400)	7.03	2	MSH2, MSH6
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	2	MSH2, MLH3
MutSalpha complex binding (GO:0032407)	8.13	2	PMS2, MLH1
single guanine insertion binding (GO:0032142)	8.64	2	MSH2, MSH6
single thymine insertion binding (GO:0032143)	9.05	2	MSH2, MSH6
oxidized DNA binding (GO:0032356)	8.13	2	MSH2, MSH6
magnesium ion binding (GO:0000287)	4.41	2	MSH2, MSH6
DNA secondary structure binding (GO:0000217)	6.6	2	MSH2, MSH6
structure-specific DNA binding (GO:0043566)	4.98	2	MSH2, MSH6
enzyme binding (GO:0019899)	2.27	2	MSH2, TGFBR2
protein kinase binding (GO:0019901)	3.44	2	MSH2, TGFBR2
kinase binding (GO:0019900)	3.32	2	MSH2, TGFBR2
identical protein binding (GO:0042802)	2.63	2	MSH2, MSH6
ADP binding (GO:0043531)	6.24	2	MSH2, MSH6
protein dimerization activity (GO:0046983)	2.72	2	MSH2, MSH6
centromeric DNA binding (GO:0019237)	7.95	2	MSH2, MLH3
damaged DNA binding (GO:0003684)	5.58	2	MSH2, MSH6
MutLalpha complex binding (GO:0032405)	7.95	2	MSH2, MSH6
protein homodimerization activity (GO:0042803)	3.16	2	MSH2, MSH6

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
purine ribonucleoside triphosphate binding (GO:0035639)	-	2.22	0.032	MSH2, PMS2, MLH3, TGFBR2, MLH1
mismatched DNA binding (GO:0030983)	-	7.25	0.0	MSH6, PMS2, MSH2, MLH3, MLH1
ATPase activity (GO:0016887)	-	3.65	0.0	MSH6, PMS2, MSH2, MLH3, MLH1
purine nucleoside binding (GO:0001883)	-	2.22	0.033	PMS2, MSH2, MLH3, TGFBR2, MLH1
nucleoside binding (GO:0001882)	-	2.21	0.034	MSH2, PMS2, MLH3, TGFBR2, MLH1
sequence-specific DNA binding (GO:0043565)	-	2.79	0.039	MSH6, MSH2, MLH3, TGFBR2, MLH1
structure-specific DNA binding (GO:0043566)	-	4.98	0.0	MSH6, PMS2, MSH2, MLH3, MLH1
ATPase activity, coupled (GO:0042623)	NEW	3.97	0.004	MSH6, MSH2, PMS2, MLH1
ribonucleoside binding (GO:0032549)	-	2.22	0.033	MSH2, PMS2, MLH3, TGFBR2, MLH1
satellite DNA binding (GO:0003696)	NEW	7.79	0.002	MLH1, MLH3
guanine/thymine mispair binding (GO:0032137)	-	8.35	0.0	MSH2, MSH6, MLH1
purine nucleotide binding (GO:0017076)	-	2.19	0.037	MSH2, PMS2, MLH3, TGFBR2, MLH1
double-stranded DNA binding (GO:0003690)	-	3.09	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
centromeric DNA binding (GO:0019237)	-	7.95	0.001	MSH2, MLH3
single-stranded DNA binding (GO:0003697)	-	5.17	0.002	MSH6, MLH1, MLH3
ATP binding (GO:0005524)	-	2.43	0.011	MSH2, PMS2, MLH3, TGFBR2, MLH1
kinase activity (GO:0016301)	NEW	2.93	0.004	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
nucleoside-triphosphatase activity (GO:0017111)	-	3.09	0.028	MSH6, MSH2, PMS2, MLH3, MLH1
DNA insertion or deletion binding (GO:0032135)	-	7.95	0.0	PMS2, MSH2
DNA-dependent ATPase activity (GO:0008094)	NEW	5.31	0.027	MSH6, PMS2, MSH2
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	-	3.03	0.039	MSH6, MSH2, PMS2, MLH3, MLH1
adenyl nucleotide binding (GO:0030554)	-	2.4	0.013	PMS2, MSH2, MLH3, TGFBR2, MLH1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	NEW	2.77	0.01	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
hydrolase activity, acting on acid anhydrides (GO:0016817)	-	3.03	0.04	MSH6, PMS2, MSH2, MLH3, MLH1
purine ribonucleoside binding (GO:0032550)	-	2.22	0.033	PMS2, MSH2, MLH3, TGFBR2, MLH1
pyrophosphatase activity (GO:0016462)	-	3.04	0.039	MSH6, MSH2, PMS2, MLH3, MLH1
adenyl ribonucleotide binding (GO:0032559)	-	2.41	0.013	PMS2, MSH2, MLH3, TGFBR2, MLH1
purine ribonucleotide binding (GO:0032555)	-	2.2	0.035	PMS2, MSH2, MLH3, TGFBR2, MLH1
damaged DNA binding (GO:0003684)	-	5.58	0.044	MSH2, MSH6
ribonucleotide binding (GO:0032553)	-	2.19	0.036	PMS2, MSH2, MLH3, TGFBR2, MLH1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	7	EPCAM, PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
primary metabolic process (GO:0044238)	0.69	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
cellular macromolecule metabolic process (GO:0044260)	0.93	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
response to stimulus (GO:0050896)	1.22	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
cellular metabolic process (GO:0044237)	0.69	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
macromolecule metabolic process (GO:0043170)	0.83	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
organic substance metabolic process (GO:0071704)	0.63	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
response to stress (GO:0006950)	1.8	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
metabolic process (GO:0008152)	0.58	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
regulation of primary metabolic process (GO:0080090)	1.08	5	MSH6, EPCAM, MSH2, MLH1, TGFBR2
regulation of metabolic process (GO:0019222)	1.02	5	MSH6, EPCAM, MSH2, MLH1, TGFBR2
regulation of cellular metabolic process (GO:0031323)	1.07	5	MSH6, EPCAM, MSH2, MLH1, TGFBR2
mismatch repair (GO:0006298)	6.23	5	MSH6, MSH2, PMS2, MLH3, MLH1
nucleic acid metabolic process (GO:0090304)	1.46	5	MSH6, MSH2, PMS2, MLH3, MLH1
cellular nitrogen compound metabolic process (GO:0034641)	1.22	5	MSH6, MSH2, PMS2, MLH3, MLH1
nitrogen compound metabolic process (GO:0006807)	1.13	5	MSH6, MSH2, PMS2, MLH3, MLH1
signal transduction (GO:0007165)	1.28	5	MSH6, EPCAM, MSH2, MLH1, TGFBR2
regulation of biological process (GO:0050789)	0.45	5	EPCAM, MSH2, MSH6, TGFBR2, MLH1
single-organism process (GO:0044699)	0.48	5	EPCAM, MSH2, MSH6, TGFBR2, MLH1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	5	MSH6, MSH2, PMS2, MLH3, MLH1
cellular response to stimulus (GO:0051716)	1.97	5	MSH6, MSH2, PMS2, MLH3, MLH1
biological regulation (GO:0065007)	0.39	5	EPCAM, MSH2, MSH6, TGFBR2, MLH1
organic cyclic compound metabolic process (GO:1901360)	1.26	5	MSH6, MSH2, PMS2, MLH3, MLH1
negative regulation of biological process (GO:0048519)	1.33	5	MSH6, EPCAM, MSH2, MLH1, TGFBR2
DNA repair (GO:0006281)	3.59	5	MSH6, MSH2, PMS2, MLH3, MLH1
regulation of macromolecule metabolic process (GO:0060255)	1.08	5	EPCAM, MSH2, MSH6, TGFBR2, MLH1
cellular aromatic compound metabolic process (GO:0006725)	1.3	5	MSH6, MSH2, PMS2, MLH3, MLH1
regulation of cellular process (GO:0050794)	0.5	5	MSH6, EPCAM, MSH2, MLH1, TGFBR2
cellular response to DNA damage stimulus (GO:0006974)	3.17	5	MSH6, MSH2, PMS2, MLH3, MLH1
reproductive process (GO:0022414)	2.55	5	MSH6, MSH2, MLH3, TGFBR2, MLH1
single-organism cellular process (GO:0044763)	0.65	5	MSH6, EPCAM, MSH2, MLH1, TGFBR2
heterocycle metabolic process (GO:0046483)	1.31	5	MSH6, MSH2, PMS2, MLH3, MLH1
immune system process (GO:0002376)	2.29	5	MSH6, MSH2, PMS2, TGFBR2, MLH1
cellular response to stress (GO:0033554)	2.51	5	MSH6, PMS2, MSH2, MLH3, MLH1
DNA metabolic process (GO:0006259)	3.09	5	MSH6, MSH2, PMS2, MLH3, MLH1
negative regulation of cellular process (GO:0048523)	1.41	5	MSH6, EPCAM, MSH2, MLH1, TGFBR2
organelle organization (GO:0006996)	2.02	4	MSH2, MSH6, MLH3, MLH1
developmental process (GO:0032502)	1.36	4	EPCAM, MSH2, MLH1, TGFBR2
single-organism metabolic process (GO:0044710)	1.63	4	MSH2, MSH6, TGFBR2, MLH1
chromosome organization (GO:0051276)	3.79	4	MSH6, MSH2, MLH1, MLH3
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	4	EPCAM, MSH2, MSH6, MLH1
cellular developmental process (GO:0048869)	1.82	4	EPCAM, MSH2, MLH1, TGFBR2
anatomical structure development (GO:0048856)	1.58	4	EPCAM, MSH2, MLH1, TGFBR2
DNA recombination (GO:0006310)	4.39	4	MSH2, MSH6, MLH3, MLH1
cellular component organization (GO:0016043)	1.24	4	MSH2, MSH6, MLH3, MLH1
meiotic cell cycle process (GO:1903046)	4.71	4	MSH2, MSH6, MLH3, MLH1
leukocyte activation (GO:0045321)	3.76	4	MSH2, MSH6, TGFBR2, MLH1
cell activation (GO:0001775)	3.47	4	MSH2, MSH6, TGFBR2, MLH1
cell cycle process (GO:0022402)	2.75	4	MSH2, MSH6, MLH3, MLH1
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	EPCAM, MSH2, MSH6, MLH1
reciprocal DNA recombination (GO:0035825)	6.33	4	MSH2, MSH6, MLH3, MLH1
reciprocal meiotic recombination (GO:0007131)	6.33	4	MSH6, MSH2, MLH1, MLH3
somatic diversification of immune receptors via somatic mutation (GO:0002566)	6.84	4	MSH6, MSH2, PMS2, MLH1
somatic diversification of immunoglobulins (GO:0016445)	6.26	4	MSH6, MSH2, PMS2, MLH1
somatic diversification of immune receptors (GO:0002200)	5.92	4	MSH6, MSH2, PMS2, MLH1
cellular component organization or biogenesis (GO:0071840)	1.22	4	MSH6, MSH2, MLH1, MLH3
somatic hypermutation of immunoglobulin genes (GO:0016446)	6.9	4	MSH6, MSH2, PMS2, MLH1
negative regulation of cellular metabolic process (GO:0031324)	2.01	3	MSH2, MSH6, MLH1
negative regulation of metabolic process (GO:0009892)	1.93	3	MSH6, MSH2, MLH1
positive regulation of metabolic process (GO:0009893)	1.74	3	EPCAM, MSH6, TGFBR2
positive regulation of cellular metabolic process (GO:0031325)	1.81	3	EPCAM, MSH6, TGFBR2
cell differentiation (GO:0030154)	2.14	3	EPCAM, MSH2, TGFBR2
apoptotic signaling pathway (GO:0097190)	4.12	3	MSH6, MSH2, MLH1
B cell activation (GO:0042113)	4.84	3	MSH6, MSH2, MLH1
intrinsic apoptotic signaling pathway (GO:0097193)	4.69	3	MSH6, MSH2, MLH1
intracellular signal transduction (GO:0035556)	2.39	3	MSH6, MSH2, MLH1
positive regulation of catalytic activity (GO:0043085)	2.4	3	MSH2, MSH6, TGFBR2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	3	MSH6, MSH2, MLH1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	3	MSH2, MSH6, MLH1
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	3	EPCAM, MSH6, TGFBR2
lymphocyte activation involved in immune response (GO:0002285)	5.22	3	MSH6, MSH2, MLH1
cell activation involved in immune response (GO:0002263)	4.86	3	MSH6, MSH2, MLH1
somatic diversification of immunoglobulins involved in immune response (GO:0002208)	6.96	3	MSH6, MSH2, MLH1
leukocyte activation involved in immune response (GO:0002366)	4.88	3	MSH6, MSH2, MLH1
isotype switching (GO:0045190)	6.96	3	MSH2, MSH6, MLH1
positive regulation of molecular function (GO:0044093)	2.23	3	MSH2, MSH6, TGFBR2
positive regulation of biological process (GO:0048518)	1.2	3	EPCAM, MSH6, TGFBR2
regulation of molecular function (GO:0065009)	1.78	3	MSH2, MSH6, TGFBR2
negative regulation of DNA recombination (GO:0045910)	6.96	3	MSH2, MSH6, MLH1
somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	6.96	3	MSH2, MSH6, MLH1
multicellular organismal process (GO:0032501)	1.45	3	MSH2, MSH6, TGFBR2
negative regulation of DNA metabolic process (GO:0051053)	4.98	3	MSH6, MSH2, MLH1
regulation of DNA metabolic process (GO:0051052)	3.87	3	MSH6, MSH2, MLH1
response to abiotic stimulus (GO:0009628)	2.8	3	MSH2, MSH6, TGFBR2
regulation of catalytic activity (GO:0050790)	1.97	3	MSH2, MSH6, TGFBR2
single-organism developmental process (GO:0044767)	1.49	3	MSH2, MLH1, TGFBR2
lymphocyte activation (GO:0046649)	3.96	3	MSH6, MSH2, MLH1
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	3	MSH6, MSH2, MLH1
localization (GO:0051179)	1.4	3	MLH1, MLH3, TGFBR2
somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562)	6.23	3	MSH6, MSH2, MLH1
single organism reproductive process (GO:0044702)	2.73	3	MSH2, MLH1, TGFBR2
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)	5.44	3	MSH6, MSH2, MLH1
single-multicellular organism process (GO:0044707)	1.78	3	MSH2, MSH6, TGFBR2
regulation of DNA recombination (GO:0000018)	5.65	3	MSH6, MSH2, MLH1
B cell activation involved in immune response (GO:0002312)	6.17	3	MSH2, MSH6, MLH1
immune effector process (GO:0002252)	3.58	3	MSH6, MSH2, MLH1
somatic cell DNA recombination (GO:0016444)	6.23	3	MSH2, MSH6, MLH1
somatic recombination of immunoglobulin gene segments (GO:0016447)	6.68	3	MSH6, MSH2, MLH1
positive regulation of cellular process (GO:0048522)	1.3	3	EPCAM, MSH6, TGFBR2
regulation of cell proliferation (GO:0042127)	2.41	2	EPCAM, TGFBR2
cellular component assembly (GO:0022607)	2.14	2	MLH1, MLH3
regulation of cell activation (GO:0050865)	3.53	2	MSH6, TGFBR2
response to radiation (GO:0009314)	3.69	2	MSH2, MSH6
positive regulation of cell activation (GO:0050867)	3.97	2	MSH6, TGFBR2
positive regulation of response to stimulus (GO:0048584)	2.18	2	MSH6, TGFBR2
cell development (GO:0048468)	3.28	2	MSH2, MLH1
regulation of cellular component organization (GO:0051128)	2.01	2	MSH2, TGFBR2
regulation of cell-cell adhesion (GO:0022407)	3.79	2	EPCAM, TGFBR2
response to UV (GO:0009411)	4.88	2	MSH2, MSH6
response to light stimulus (GO:0009416)	4.08	2	MSH2, MSH6
response to chemical (GO:0042221)	1.98	2	PMS2, TGFBR2
regulation of localization (GO:0032879)	1.94	2	EPCAM, TGFBR2
regulation of cell death (GO:0010941)	2.43	2	EPCAM, MSH2
regulation of apoptotic process (GO:0042981)	2.5	2	EPCAM, MSH2
multicellular organism development (GO:0007275)	2.54	2	MSH2, TGFBR2
male meiosis (GO:0007140)	6.59	2	MLH1, MLH3
meiotic nuclear division (GO:0007126)	5.37	2	MLH1, MLH3
establishment of localization (GO:0051234)	1.48	2	MLH1, TGFBR2
double-strand break repair (GO:0006302)	4.73	2	MSH2, MLH1
positive regulation of hydrolase activity (GO:0051345)	2.91	2	MSH2, MSH6
positive regulation of multicellular organismal process (GO:0051240)	2.49	2	MSH6, TGFBR2
nuclear division (GO:0000280)	3.85	2	MLH1, MLH3
positive regulation of immune system process (GO:0002684)	2.96	2	MSH6, TGFBR2
regulation of cellular component movement (GO:0051270)	3.08	2	EPCAM, TGFBR2
regulation of programmed cell death (GO:0043067)	2.49	2	EPCAM, MSH2
negative regulation of apoptotic process (GO:0043066)	3.04	2	EPCAM, MSH2
regulation of immune system process (GO:0002682)	2.5	2	MSH6, TGFBR2
phosphorylation (GO:0016310)	2.63	2	MSH2, TGFBR2
embryo development ending in birth or egg hatching (GO:0009792)	4.35	2	MSH2, TGFBR2
regulation of cell motility (GO:2000145)	3.16	2	EPCAM, TGFBR2
chordate embryonic development (GO:0043009)	4.38	2	MSH2, TGFBR2
negative regulation of programmed cell death (GO:0043069)	3.02	2	EPCAM, MSH2
regulation of cell adhesion (GO:0030155)	3.27	2	EPCAM, TGFBR2
organelle fission (GO:0048285)	3.79	2	MLH1, MLH3
positive regulation of cell proliferation (GO:0008284)	3.01	2	EPCAM, TGFBR2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	2	EPCAM, MSH6
regulation of developmental process (GO:0050793)	2.1	2	MSH6, TGFBR2
negative regulation of cell death (GO:0060548)	2.95	2	EPCAM, MSH2
tissue development (GO:0009888)	3.27	2	EPCAM, TGFBR2
regulation of response to stimulus (GO:0048583)	1.54	2	MSH6, TGFBR2
germ cell development (GO:0007281)	4.75	2	MSH2, MLH1
animal organ development (GO:0048513)	2.53	2	MSH2, TGFBR2
regulation of lymphocyte activation (GO:0051249)	3.73	2	MSH6, TGFBR2
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	2	EPCAM, MSH6
regulation of multicellular organismal process (GO:0051239)	1.87	2	MSH6, TGFBR2
cellular process involved in reproduction in multicellular organism (GO:0022412)	4.3	2	MSH2, MLH1
determination of adult lifespan (GO:0008340)	7.09	2	MSH2, MSH6
tube development (GO:0035295)	4.41	2	EPCAM, TGFBR2
maintenance of DNA repeat elements (GO:0043570)	8.12	2	MSH2, MSH6
leukocyte differentiation (GO:0002521)	4.13	2	MSH2, TGFBR2
positive regulation of helicase activity (GO:0051096)	7.94	2	MSH2, MSH6
regulation of hydrolase activity (GO:0051336)	2.53	2	MSH2, MSH6
positive regulation of cellular component movement (GO:0051272)	3.71	2	EPCAM, TGFBR2
regulation of locomotion (GO:0040012)	3.12	2	EPCAM, TGFBR2
chromosome organization involved in meiotic cell cycle (GO:0070192)	5.9	2	MLH1, MLH3
positive regulation of locomotion (GO:0040017)	3.71	2	EPCAM, TGFBR2
developmental process involved in reproduction (GO:0003006)	3.36	2	MSH2, MLH1
positive regulation of lymphocyte activation (GO:0051251)	4.07	2	MSH6, TGFBR2
meiotic mismatch repair (GO:0000710)	8.12	2	MSH2, MSH6
positive regulation of developmental process (GO:0051094)	2.77	2	MSH6, TGFBR2
response to drug (GO:0042493)	3.71	2	PMS2, TGFBR2
regulation of gene expression (GO:0010468)	1.37	2	EPCAM, TGFBR2
regulation of leukocyte activation (GO:0002694)	3.6	2	MSH6, TGFBR2
phosphate-containing compound metabolic process (GO:0006796)	2.16	2	MSH2, TGFBR2
positive regulation of leukocyte activation (GO:0002696)	4.0	2	MSH6, TGFBR2
regulation of multicellular organismal development (GO:2000026)	2.31	2	MSH6, TGFBR2
regulation of helicase activity (GO:0051095)	7.53	2	MSH2, MSH6
positive regulation of cell motility (GO:2000147)	3.74	2	EPCAM, TGFBR2
phosphorus metabolic process (GO:0006793)	2.15	2	MSH2, TGFBR2
embryo development (GO:0009790)	4.2	2	MSH2, TGFBR2
in utero embryonic development (GO:0001701)	4.4	2	MSH2, TGFBR2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
organophosphate catabolic process (GO:0046434)	NEW	5.03	0.001	MSH6, MSH2, PMS2, MLH3, MLH1
nucleotide catabolic process (GO:0009166)	NEW	5.67	0.001	MSH6, MSH2, PMS2, MLH3, MLH1
purine ribonucleoside monophosphate metabolic process (GO:0009167)	NEW	4.7	0.01	MSH6, MSH2, PMS2, MLH3, MLH1
nucleoside catabolic process (GO:0009164)	NEW	6.17	0.001	MSH6, MSH2, PMS2, MLH3, MLH1
ribonucleoside monophosphate metabolic process (GO:0009161)	NEW	4.62	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
purine ribonucleoside catabolic process (GO:0046130)	NEW	7.16	0.0	MSH6, PMS2, MSH2, MLH3, MLH1
purine ribonucleoside monophosphate catabolic process (GO:0009169)	NEW	8.12	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
single-organism catabolic process (GO:0044712)	NEW	3.21	0.021	MSH6, MSH2, PMS2, MLH3, MLH1
cell activation involved in immune response (GO:0002263)	-	4.86	0.004	MSH6, MSH2, MLH1
ribonucleoside triphosphate metabolic process (GO:0009199)	NEW	4.77	0.001	MSH6, MSH2, PMS2, MLH3, MLH1
ribonucleoside catabolic process (GO:0042454)	NEW	6.55	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
purine ribonucleoside triphosphate catabolic process (GO:0009207)	NEW	9.73	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
purine ribonucleoside triphosphate metabolic process (GO:0009205)	NEW	4.81	0.001	MSH6, PMS2, MSH2, MLH3, MLH1
negative regulation of DNA metabolic process (GO:0051053)	-	4.98	0.041	MSH6, MSH2, MLH1
DNA repair (GO:0006281)	-	3.59	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
ATP metabolic process (GO:0046034)	NEW	4.98	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
purine ribonucleoside metabolic process (GO:0046128)	NEW	4.33	0.001	MSH6, MSH2, PMS2, MLH3, MLH1
intrinsic apoptotic signaling pathway in response to DNA damage (GO:0008630)	-	5.44	0.002	MSH6, MSH2, MLH1
organonitrogen compound catabolic process (GO:1901565)	NEW	3.91	0.003	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
resolution of meiotic recombination intermediates (GO:0000712)	NEW	7.43	0.027	MSH2, MLH1
meiotic mismatch repair (GO:0000710)	-	8.12	0.0	MSH2, MSH6
regulation of DNA recombination (GO:0000018)	-	5.65	0.0	MSH6, MSH2, MLH1
purine nucleotide metabolic process (GO:0006163)	NEW	4.09	0.002	MSH6, MSH2, PMS2, MLH3, MLH1
cellular response to stress (GO:0033554)	-	2.51	0.013	MSH6, MSH2, PMS2, MLH3, MLH1
organophosphate metabolic process (GO:0019637)	NEW	3.04	0.021	MSH6, MSH2, PMS2, MLH3, MLH1
somatic diversification of immunoglobulins (GO:0016445)	-	6.26	0.0	MSH6, MSH2, PMS2, MLH1
somatic cell DNA recombination (GO:0016444)	-	6.23	0.0	MSH6, MSH2, PMS2, MLH1
somatic recombination of immunoglobulin gene segments (GO:0016447)	-	6.68	0.0	MSH6, MSH2, PMS2, MLH1
somatic hypermutation of immunoglobulin genes (GO:0016446)	-	6.9	0.0	MSH6, MSH2, PMS2, MLH1
nucleoside triphosphate metabolic process (GO:0009141)	NEW	4.61	0.001	MSH6, PMS2, MSH2, MLH3, MLH1
nucleoside triphosphate catabolic process (GO:0009143)	NEW	7.24	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
purine nucleoside triphosphate metabolic process (GO:0009144)	NEW	4.76	0.001	MSH6, PMS2, MSH2, MLH3, MLH1
mismatch repair (GO:0006298)	-	6.23	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
purine nucleoside triphosphate catabolic process (GO:0009146)	NEW	7.94	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
leukocyte activation (GO:0045321)	-	3.76	0.003	MSH2, MSH6, TGFBR2, MLH1
purine nucleotide catabolic process (GO:0006195)	NEW	6.07	0.001	MSH6, MSH2, PMS2, MLH3, MLH1
lymphocyte activation involved in immune response (GO:0002285)	-	5.22	0.001	MSH6, MSH2, MLH1
somatic diversification of immunoglobulins involved in immune response (GO:0002208)	-	6.96	0.0	MSH6, MSH2, MLH1
leukocyte activation involved in immune response (GO:0002366)	-	4.88	0.004	MSH6, MSH2, MLH1
somatic diversification of immune receptors (GO:0002200)	-	5.92	0.0	MSH6, MSH2, PMS2, MLH1
negative regulation of DNA recombination (GO:0045910)	-	6.96	0.0	MSH2, MSH6, MLH1
somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)	-	6.96	0.0	MSH2, MSH6, MLH1
ribonucleoside monophosphate catabolic process (GO:0009158)	NEW	8.12	0.0	MSH6, PMS2, MSH2, MLH3, MLH1
purine ribonucleotide catabolic process (GO:0009154)	NEW	6.47	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
purine ribonucleotide metabolic process (GO:0009150)	NEW	4.16	0.001	MSH6, MSH2, PMS2, MLH3, MLH1
ribonucleotide catabolic process (GO:0009261)	NEW	6.43	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
aromatic compound catabolic process (GO:0019439)	NEW	3.79	0.005	MSH6, MSH2, PMS2, MLH3, MLH1
response to stress (GO:0006950)	-	1.8	0.042	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
nucleobase-containing compound catabolic process (GO:0034655)	NEW	3.9	0.004	MSH6, MSH2, PMS2, MLH3, MLH1
heterocycle catabolic process (GO:0046700)	NEW	3.82	0.005	MSH6, MSH2, PMS2, MLH3, MLH1
chromosome organization involved in meiosis (GO:0070192)	-	5.9	0.045	MSH2, MLH1, MLH3
chromosome organization (GO:0051276)	-	3.79	0.028	MSH2, MLH1, MLH3
cell activation (GO:0001775)	-	3.47	0.017	MSH2, MSH6, TGFBR2, MLH1
nucleoside phosphate catabolic process (GO:1901292)	NEW	5.54	0.001	MSH6, MSH2, PMS2, MLH3, MLH1
nucleoside phosphate metabolic process (GO:0006753)	NEW	3.71	0.004	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
purine nucleoside monophosphate catabolic process (GO:0009128)	NEW	7.94	0.003	MSH6, PMS2, MSH2, MLH3, MLH1
nucleoside monophosphate metabolic process (GO:0009123)	NEW	4.54	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
purine nucleoside monophosphate metabolic process (GO:0009126)	NEW	4.69	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
ribonucleotide metabolic process (GO:0009259)	NEW	4.11	0.002	MSH6, MSH2, PMS2, MLH3, MLH1
nucleoside monophosphate catabolic process (GO:0009125)	NEW	7.65	0.004	MSH6, MSH2, PMS2, MLH3, MLH1
purine nucleoside metabolic process (GO:0042278)	NEW	4.32	0.001	MSH6, MSH2, PMS2, MLH3, MLH1
synapsis (GO:0007129)	NEW	6.78	0.025	MSH2, MLH1
isotype switching (GO:0045190)	-	6.96	0.0	MSH2, MSH6, MLH1
cellular response to DNA damage stimulus (GO:0006974)	-	3.17	0.002	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
reciprocal meiotic recombination (GO:0007131)	-	6.33	0.001	MLH1, MSH6, MLH3
intrinsic apoptotic signaling pathway (GO:0097193)	-	4.69	0.015	MSH6, MSH2, MLH1
nucleobase-containing small molecule metabolic process (GO:0055086)	NEW	3.59	0.006	MSH6, MSH2, PMS2, MLH3, MLH1
cellular nitrogen compound catabolic process (GO:0044270)	NEW	3.8	0.005	MSH6, MSH2, PMS2, MLH3, MLH1
positive regulation of helicase activity (GO:0051096)	-	7.94	0.004	MSH2, MSH6
regulation of helicase activity (GO:0051095)	-	7.53	0.002	MSH2, MSH6
carbohydrate derivative catabolic process (GO:1901136)	NEW	4.61	0.013	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
carbohydrate derivative metabolic process (GO:1901135)	NEW	3.07	0.02	MSH6, MSH2, PMS2, MLH3, MLH1
ribonucleoside triphosphate catabolic process (GO:0009203)	NEW	9.73	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
B cell activation (GO:0042113)	-	4.84	0.006	MSH6, MSH2, MLH1
meiotic cell cycle process (GO:1903046)	-	4.71	0.0	MSH2, MSH6, MLH3, MLH1
cell cycle process (GO:0022402)	-	2.75	0.033	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
meiotic chromosome separation (GO:0051307)	NEW	9.04	0.03	MSH2, MLH1
purine-containing compound metabolic process (GO:0072521)	NEW	4.0	0.002	MSH6, MSH2, PMS2, MLH3, MLH1
female meiosis I (GO:0007144)	NEW	8.34	0.004	MSH6, MLH3
purine-containing compound catabolic process (GO:0072523)	NEW	5.92	0.001	MSH6, MSH2, PMS2, MLH3, MLH1
purine nucleoside catabolic process (GO:0006152)	NEW	7.16	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
organic cyclic compound catabolic process (GO:1901361)	NEW	3.73	0.006	MSH6, MSH2, PMS2, MLH3, MLH1
nucleotide metabolic process (GO:0009117)	NEW	3.73	0.004	MSH6, MSH2, PMS2, MLH3, MLH1
nucleoside metabolic process (GO:0009116)	NEW	4.12	0.002	MSH6, MSH2, PMS2, MLH3, MLH1
determination of adult lifespan (GO:0008340)	-	7.09	0.004	MSH2, MSH6
ribonucleoside metabolic process (GO:0009119)	NEW	4.21	0.001	MSH6, MSH2, PMS2, MLH3, MLH1
DNA recombination (GO:0006310)	-	4.39	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
somatic diversification of immune receptors via germline recombination within a single locus (GO:0002562)	-	6.23	0.0	MSH6, MSH2, PMS2, MLH1
somatic diversification of immune receptors via somatic mutation (GO:0002566)	-	6.84	0.0	MSH6, MSH2, PMS2, MLH1
ribose phosphate metabolic process (GO:0019693)	NEW	4.06	0.002	MSH6, MSH2, PMS2, MLH3, MLH1
glycosyl compound metabolic process (GO:1901657)	NEW	4.04	0.002	MSH6, MSH2, PMS2, MLH3, MLH1
phosphate-containing compound metabolic process (GO:0006796)	-	2.16	0.022	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
B cell activation involved in immune response (GO:0002312)	-	6.17	0.0	MSH2, MSH6, MLH1
phosphorus metabolic process (GO:0006793)	-	2.15	0.024	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
DNA metabolic process (GO:0006259)	-	3.09	0.002	MSH6, MSH2, PMS2, MLH3, MLH1
reciprocal DNA recombination (GO:0035825)	-	6.33	0.001	MSH6, MLH1, MLH3
glycosyl compound catabolic process (GO:1901658)	NEW	6.02	0.001	MSH6, MSH2, PMS2, MLH3, MLH1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	7	EPCAM, PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
protein complex (GO:0043234)	1.51	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
membrane-bounded organelle (GO:0043227)	0.47	6	EPCAM, PMS2, MSH2, MSH6, MLH1, MLH3
intracellular part (GO:0044424)	0.28	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
macromolecular complex (GO:0032991)	1.35	6	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
organelle (GO:0043226)	0.4	6	EPCAM, PMS2, MSH2, MSH6, MLH1, MLH3
intracellular membrane-bounded organelle (GO:0043231)	0.6	5	MSH6, MSH2, PMS2, MLH3, MLH1
DNA repair complex (GO:1990391)	6.14	5	MSH6, PMS2, MSH2, MLH3, MLH1
nucleus (GO:0005634)	1.07	5	MSH6, PMS2, MSH2, MLH3, MLH1
membrane (GO:0016020)	0.68	5	EPCAM, MSH2, MSH6, MLH1, TGFBR2
intracellular organelle part (GO:0044446)	0.81	5	MSH6, PMS2, MSH2, MLH3, MLH1
intracellular organelle (GO:0043229)	0.51	5	MSH6, PMS2, MSH2, MLH3, MLH1
mismatch repair complex (GO:0032300)	7.03	5	MSH6, MSH2, PMS2, MLH3, MLH1
nuclear part (GO:0044428)	1.55	5	MSH6, MSH2, PMS2, MLH3, MLH1
organelle part (GO:0044422)	0.79	5	MSH6, MSH2, PMS2, MLH3, MLH1
nucleoplasm (GO:0005654)	1.89	4	MSH6, MSH2, PMS2, MLH1
nuclear chromosome part (GO:0044454)	3.67	4	MSH6, MSH2, MLH1, MLH3
non-membrane-bounded organelle (GO:0043228)	1.76	4	PMS2, MSH6, MLH3, MLH1
chromosomal part (GO:0044427)	3.18	4	MSH2, MSH6, MLH3, MLH1
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	4	MSH6, PMS2, MLH1, MLH3
cytoplasm (GO:0005737)	1.01	3	PMS2, MSH6, TGFBR2
nuclear chromosome (GO:0000228)	5.55	3	MLH1, MSH6, MLH3
chromosome (GO:0005694)	3.78	3	MSH6, MLH1, MLH3
plasma membrane (GO:0005886)	1.39	3	EPCAM, MSH6, TGFBR2
plasma membrane region (GO:0098590)	2.97	2	EPCAM, TGFBR2
male germ cell nucleus (GO:0001673)	6.97	2	MLH1, MLH3
condensed nuclear chromosome (GO:0000794)	6.11	2	MLH1, MLH3
plasma membrane part (GO:0044459)	1.95	2	EPCAM, TGFBR2
integral component of membrane (GO:0016021)	1.14	2	EPCAM, TGFBR2
chiasma (GO:0005712)	8.42	2	MLH1, MLH3
membrane part (GO:0044425)	0.95	2	EPCAM, TGFBR2
condensed chromosome (GO:0000793)	5.64	2	MLH1, MLH3
cytoplasmic part (GO:0044444)	0.82	2	MSH6, TGFBR2
germ cell nucleus (GO:0043073)	6.76	2	MLH1, MLH3
integral component of plasma membrane (GO:0005887)	2.57	2	EPCAM, TGFBR2
synaptonemal complex (GO:0000795)	6.54	2	MLH1, MLH3
MutSalpha complex (GO:0032301)	9.11	2	MSH2, MSH6
intrinsic component of plasma membrane (GO:0031226)	2.53	2	EPCAM, TGFBR2
cell surface (GO:0009986)	3.44	2	EPCAM, TGFBR2
intrinsic component of membrane (GO:0031224)	1.13	2	EPCAM, TGFBR2
MutLalpha complex (GO:0032389)	7.72	2	PMS2, MLH1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein complex (GO:0043234)	-	1.51	0.034	PMS2, MSH2, TGFBR2, MSH6, MLH1, MLH3
MutLalpha complex (GO:0032389)	-	7.72	0.0	PMS2, MLH1
DNA repair complex (GO:1990391)	-	6.14	0.0	MSH6, PMS2, MSH2, MLH3, MLH1
chiasma (GO:0005712)	-	8.42	0.0	MLH1, MLH3
nuclear chromosome part (GO:0044454)	-	3.67	0.01	MSH6, MSH2, PMS2, MLH3, MLH1
mismatch repair complex (GO:0032300)	-	7.03	0.0	MSH6, MSH2, PMS2, MLH3, MLH1
MutSalpha complex (GO:0032301)	-	9.11	0.0	MSH2, MSH6
synaptonemal complex (GO:0000795)	-	6.54	0.004	MLH1, MLH3
nuclear chromosome (GO:0000228)	-	5.55	0.01	MSH2, MSH6
chromosomal part (GO:0044427)	-	3.18	0.008	MSH6, MSH2, PMS2, MLH3, MLH1
male germ cell nucleus (GO:0001673)	-	6.97	0.001	MLH1, MSH6, MLH3
germ cell nucleus (GO:0043073)	-	6.76	0.002	MLH1, MSH6, MLH3