Disease table of AORTIC ANEURYSM, FAMILIAL THORACIC OMIM ID: PS607086

Gene-disease associations table

GeneAssociated with AORTIC ANEURYSM, FAMILIAL THORACIC inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ACTA2ClinVar, OMIM, HUMSAVARHGNC link10q23.313613834, PS607086, PS252350
MYH11ClinVar, OMIM, HUMSAVARHGNC link16p13.113154700, 155310, PS607086
TGFBR1ClinVar, OMIM, HUMSAVARHGNC link9q22.333PS609192, 132800, PS607086
TGFBR2ClinVar, OMIM, HUMSAVARHGNC link3p24.14133239, PS120435, PS607086, PS609192
MYLKClinVar, OMIM, HUMSAVARHGNC link3q21.12PS100070, PS607086
MFAP5ClinVar, OMIM, HUMSAVARHGNC link12p13.311PS607086
PRKG1ClinVar, OMIM, HUMSAVARHGNC link10q11.231PS607086

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
10q2PRKG1, ACTA2
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
102PRKG1, ACTA2
32TGFBR2, MYLK
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
ACTA2YES2HEY1, HEY20
MYH11YES1KLF50
TGFBR1YES2SMAD7, WWP10
TGFBR2YES5SP1, ETV4, ETS1, FLI1, EGR10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ACTA2MYH11Yes6YWHAE, MYOC, RPA1, RPA2, RPA3, YWHAQ
ACTA2TGFBR1No4TPM1, EP300, SMURF2, MYOC
ACTA2TGFBR2No1SMURF2
ACTA2MYLKNo2MYH9, TP53
MYH11TGFBR1No1MYOC
MYH11TGFBR2No1DAXX
TGFBR1TGFBR2Yes29SH3KBP1, OXSR1, CDC42, FBXO34, TRAF4, PEG10, SNX6, SMAD7, PIK3R2, CLU, MAP3K7, TGFB1, DAB2, SMURF1, ARHGEF6, STRAP, TRAF6, HSP90AA1, SMURF2, PAK1, TGFBRAP1, PPP1R16B, NRP1, ENG, PIK3R1, TSC22D1, AP2B1, KCNK18, OCLN
TGFBR1MYLKNo1PAK1
TGFBR2MYLKNo2GOPC, PAK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TGFBR1TGFBR2Yes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
ACTA2MYH11Yesbinding29TPM1, CALD1, MYH8, VCL, MYH7, MYH9, MYH3, MYL6B, TPM2, MYH6, MYH1, MYH14, TLN1, ACTG2, SORBS3, ITGB5, MYH2, MYH4, MYL9, PXN, MYL12B, MYH10, MYL6, SORBS1, TPM3, ITGA1, LMOD1, UBC, TPM4
ACTA2TGFBR1No-2TGFB1, UBC
ACTA2TGFBR2No-2TGFB1, UBC
ACTA2MYLKNo-9MYL6, MYL9, ITGA1, MYH14, MYOCD, PXN, MYL12B, MYL6B, TLN1
MYH11TGFBR1No-5UBC, RHOA, CGN, NOTCH1, HSP90AA1
MYH11TGFBR2No-4UBC, RHOA, CGN, HSP90AA1
MYH11MYLKNo-11MYLPF, MYL12A, MYL6, MYL9, MYL5, ITGA1, MYH14, PXN, MYL12B, MYL6B, TLN1
MYH11MFAP5No-1NOTCH1
MYH11PRKG1No-2RHOA, TNNI1
TGFBR1TGFBR2Yesbinding67SAR1A, ZFYVE9, CTGF, WWP1, PRKCZ, UCHL5, GPC1, SMAD4, PARD6A, USP15, CAV1, NRP1, ARHGEF18, PPP2R2A, EIF2A, PARD3, BAMBI, ACVR1, HSP90AA1, SPTBN1, NR2C2, NEDD4L, UBC, PML, SMAD7, MAP3K7, SMAD6, PPP2R5D, AXIN1, TGFB1, SMAD3, CTNNB1, SMAD9, SHC1, TGFBR3, DAB2, SMURF1, TGFB2, PPP1R15A, DYNLRB1, UBA52, ZFYVE16, STRAP, RPS27A, SMAD2, SMAD5, RPS6KB1, CGN, PPP1CB, ACVRL1, PDPK1, YAP1, PPP1CC, TAB1, TGFBRAP1, UBB, ITGAV, FKBP1A, TGFB3, XIAP, PPP1CA, ENG, F11R, TAB2, SMAD1, RHOA, OCLN
TGFBR1MFAP5No-1NOTCH1
TGFBR1PRKG1No-8BMPR2, SMAD4, PPP1CB, PPP1CA, RHOA, PPP1CC, MAPK14, TAB1
TGFBR2PRKG1No-6RHOA, SMAD4, PPP1CB, PPP1CA, PPP1CC, TAB1
MYLKPRKG1No-2HSPB3, HSPB2-C11ORF52

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
TGFBR1TGFBR2YesTGF-beta receptor II-TGF-beta receptor I-TGF-beta3 complex;TGF-beta receptor II-TGF-beta receptor I-TGF-beta1 complex;TGF-beta-receptor-PAR6 complex;TGF-beta receptor-SMAD3 complex5TGFB1, TGFB3, PARD6A, SMAD3, TGFBR2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ACTA2MYH11Yes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
TGFBR1TGFBR2Yes4TGFB1, TGFBR1, TGFB3, TGFBR2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Vascular smooth muscle contractionhsa042705.744MYLK, MYH11, PRKG1, ACTA2
TGF-beta signaling pathwayhsa043506.412TGFBR1, TGFBR2
Platelet activationhsa046115.662MYLK, PRKG1
cGMP-PKG signaling pathwayhsa040225.322MYLK, PRKG1
Colorectal cancerhsa052106.522TGFBR1, TGFBR2
Chronic myeloid leukemiahsa052206.482TGFBR1, TGFBR2
Pathways in cancerhsa052003.982TGFBR1, TGFBR2
Chagas disease (American trypanosomiasis)hsa051425.992TGFBR1, TGFBR2
Pancreatic cancerhsa052126.562TGFBR1, TGFBR2
Adherens junctionhsa045206.262TGFBR1, TGFBR2
Hippo signaling pathwayhsa043905.372TGFBR1, TGFBR2
Endocytosishsa041444.922TGFBR1, TGFBR2
FoxO signaling pathwayhsa040685.632TGFBR1, TGFBR2
Osteoclast differentiationhsa043805.642TGFBR1, TGFBR2
HTLV-I infectionhsa051664.592TGFBR1, TGFBR2
MAPK signaling pathwayhsa040104.632TGFBR1, TGFBR2
Cytokine-cytokine receptor interactionhsa040604.672TGFBR1, TGFBR2

NET-GE enrichment

Term New enriched termICP valueGenes
TGF-beta signaling pathway (hsa04350) -6.410.023TGFBR1, PRKG1, TGFBR2
Cardiovascular diseasesNEW5.060.021TGFBR1, MYH11, MYLK, PRKG1
Digestive systemNEW4.120.034MFAP5, TGFBR1, MYH11, MYLK, PRKG1
Dilated cardiomyopathy (hsa05414) NEW6.080.001TGFBR1, MYH11, MYLK, PRKG1
Adherens junction (hsa04520) -6.260.016TGFBR1, MYH11, TGFBR2
Circulatory systemNEW4.630.002MYLK, MYH11, PRKG1, ACTA2
Focal adhesion (hsa04510) NEW4.920.001MYLK, TGFBR1, MYH11, PRKG1, TGFBR2
Cellular communityNEW3.570.001MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
Hypertrophic cardiomyopathy (HCM) (hsa05410) NEW6.210.021TGFBR1, MYH11, MYLK
Regulation of actin cytoskeleton (hsa04810) NEW4.90.03TGFBR1, MYH11, MYLK, PRKG1
Cell motilityNEW4.90.03TGFBR1, MYH11, MYLK, PRKG1
Vascular smooth muscle contraction (hsa04270) -5.740.0MYLK, MYH11, PRKG1, ACTA2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.785MYLK, TGFBR1, MYH11, PRKG1, TGFBR2
Muscle contractionR-HSA-3970146.963MYH11, MYLK, ACTA2
Smooth Muscle ContractionR-HSA-4453558.233MYH11, MYLK, ACTA2
RHO GTPase EffectorsR-HSA-1952584.942MYH11, MYLK
SMAD2/3 Phosphorylation Motif Mutants in CancerR-HSA-330435610.42TGFBR1, TGFBR2
SMAD2/3 MH2 Domain Mutants in CancerR-HSA-331548710.182TGFBR1, TGFBR2
TGFBR2 Kinase Domain Mutants in CancerR-HSA-364579010.982TGFBR1, TGFBR2
Diseases of signal transductionR-HSA-56632024.892TGFBR1, TGFBR2
Signaling by TGF-beta Receptor Complex in CancerR-HSA-33043519.982TGFBR1, TGFBR2
Signaling by TGF-beta Receptor ComplexR-HSA-1708346.812TGFBR1, TGFBR2
Signaling by Rho GTPasesR-HSA-1943154.432MYH11, MYLK
Loss of Function of SMAD2/3 in CancerR-HSA-330434910.182TGFBR1, TGFBR2
TGFBR1 KD Mutants in CancerR-HSA-365653210.182TGFBR1, TGFBR2
TGFBR1 LBD Mutants in CancerR-HSA-365653510.982TGFBR1, TGFBR2
Loss of Function of TGFBR1 in CancerR-HSA-365653410.182TGFBR1, TGFBR2
TGF-beta receptor signaling activates SMADsR-HSA-21737897.982TGFBR1, TGFBR2
Downregulation of TGF-beta receptor signalingR-HSA-21737888.282TGFBR1, TGFBR2
Loss of Function of TGFBR2 in CancerR-HSA-364227810.982TGFBR1, TGFBR2
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)R-HSA-21737918.982TGFBR1, TGFBR2
DiseaseR-HSA-16436853.332TGFBR1, TGFBR2
RHO GTPases activate PAKsR-HSA-56271238.592MYH11, MYLK

NET-GE enrichment

Term New enriched termICP valueGenes
RHO GTPase Effectors (R-HSA-195258) -4.940.038TGFBR1, MYH11, MYLK, PRKG1
SMAD2/3 Phosphorylation Motif Mutants in Cancer (R-HSA-3304356) -10.40.001TGFBR1, TGFBR2
Signaling by TGF-beta Receptor Complex in Cancer (R-HSA-3304351) -9.980.001TGFBR1, TGFBR2
TGFBR2 Kinase Domain Mutants in Cancer (R-HSA-3645790) -10.980.0TGFBR1, TGFBR2
SMAD2/3 MH2 Domain Mutants in Cancer (R-HSA-3315487) -10.180.001TGFBR1, TGFBR2
Loss of Function of TGFBR2 in Cancer (R-HSA-3642278) -10.980.0TGFBR1, TGFBR2
Elastic fibre formation (R-HSA-1566948) NEW7.490.003MFAP5, TGFBR1, TGFBR2
Loss of Function of SMAD2/3 in Cancer (R-HSA-3304349) -10.180.001TGFBR1, TGFBR2
RHO GTPases activate PAKs (R-HSA-5627123) -8.590.0MYH11, MYLK, PRKG1
Muscle contraction (R-HSA-397014) -6.960.001MYH11, MYLK, ACTA2
TGFBR1 KD Mutants in Cancer (R-HSA-3656532) -10.180.001TGFBR1, TGFBR2
TGFBR1 LBD Mutants in Cancer (R-HSA-3656535) -10.980.0TGFBR1, TGFBR2
Loss of Function of TGFBR1 in Cancer (R-HSA-3656534) -10.180.001TGFBR1, TGFBR2
TGF-beta receptor signaling activates SMADs (R-HSA-2173789) -7.980.03TGFBR1, TGFBR2
Downregulation of TGF-beta receptor signaling (R-HSA-2173788) -8.280.016TGFBR1, TGFBR2
Extracellular matrix organization (R-HSA-1474244) NEW4.910.045TGFBR1, MYH11, MFAP5, TGFBR2
Molecules associated with elastic fibres (R-HSA-2129379) NEW7.730.001TGFBR1, MFAP5, TGFBR2
Hemostasis (R-HSA-109582) NEW3.980.005MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
Smooth Muscle Contraction (R-HSA-445355) -8.230.0MYH11, MYLK, ACTA2
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (R-HSA-2173791) -8.980.005TGFBR1, TGFBR2
Visual phototransduction (R-HSA-2187338) NEW6.440.001TGFBR1, PRKG1, TGFBR2, ACTA2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.186MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
adenyl nucleotide binding (GO:0030554) 2.46MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
purine ribonucleoside triphosphate binding (GO:0035639) 2.226MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
organic cyclic compound binding (GO:0097159) 1.056MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
ribonucleotide binding (GO:0032553) 2.196MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
ATP binding (GO:0005524) 2.436MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
small molecule binding (GO:0036094) 1.896MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
carbohydrate derivative binding (GO:0097367) 2.036MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
purine ribonucleoside binding (GO:0032550) 2.226MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
adenyl ribonucleotide binding (GO:0032559) 2.416MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
nucleoside phosphate binding (GO:1901265) 1.966MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
protein binding (GO:0005515) 0.466MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
ribonucleoside binding (GO:0032549) 2.226MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
purine ribonucleotide binding (GO:0032555) 2.26MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
purine nucleotide binding (GO:0017076) 2.196MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
nucleotide binding (GO:0000166) 1.966MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
heterocyclic compound binding (GO:1901363) 1.066MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
purine nucleoside binding (GO:0001883) 2.226MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
nucleoside binding (GO:0001882) 2.216MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
catalytic activity (GO:0003824) 1.055MYLK, TGFBR1, MYH11, PRKG1, TGFBR2
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.084MYLK, TGFBR1, PRKG1, TGFBR2
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.774MYLK, TGFBR1, PRKG1, TGFBR2
kinase activity (GO:0016301) 2.934MYLK, TGFBR1, PRKG1, TGFBR2
protein serine/threonine kinase activity (GO:0004674) 3.644MYLK, TGFBR1, PRKG1, TGFBR2
transferase activity (GO:0016740) 1.954MYLK, TGFBR1, PRKG1, TGFBR2
protein kinase activity (GO:0004672) 3.274MYLK, TGFBR1, PRKG1, TGFBR2
cation binding (GO:0043169) 1.43TGFBR1, MYLK, TGFBR2
metal ion binding (GO:0046872) 1.413TGFBR1, MYLK, TGFBR2
ion binding (GO:0043167) 1.363TGFBR1, MYLK, TGFBR2
cytokine receptor binding (GO:0005126) 4.142TGFBR1, TGFBR2
signaling receptor activity (GO:0038023) 2.492TGFBR1, TGFBR2
transforming growth factor beta receptor binding (GO:0005160) 5.812TGFBR1, TGFBR2
cytokine binding (GO:0019955) 5.212TGFBR1, TGFBR2
enzyme binding (GO:0019899) 2.272TGFBR2, ACTA2
molecular transducer activity (GO:0060089) 2.322TGFBR1, TGFBR2
receptor activity (GO:0004872) 2.322TGFBR1, TGFBR2
signal transducer activity (GO:0004871) 2.282TGFBR1, TGFBR2
transforming growth factor beta binding (GO:0050431) 6.972TGFBR1, TGFBR2
transmembrane receptor protein serine/threonine kinase activity (GO:0004675) 6.912TGFBR1, TGFBR2
receptor signaling protein activity (GO:0005057) 4.762TGFBR1, TGFBR2
growth factor binding (GO:0019838) 4.892TGFBR1, TGFBR2
structural molecule activity (GO:0005198) 3.12MFAP5, MYH11
actin binding (GO:0003779) 3.742MYH11, MYLK
protein kinase binding (GO:0019901) 3.442TGFBR2, ACTA2
kinase binding (GO:0019900) 3.322TGFBR2, ACTA2
SMAD binding (GO:0046332) 5.452TGFBR1, TGFBR2
cytoskeletal protein binding (GO:0008092) 3.022MYH11, MYLK
transforming growth factor beta-activated receptor activity (GO:0005024) 7.442TGFBR1, TGFBR2
transmembrane signaling receptor activity (GO:0004888) 2.572TGFBR1, TGFBR2
calmodulin binding (GO:0005516) 4.552MYH11, MYLK
receptor signaling protein serine/threonine kinase activity (GO:0004702) 5.232TGFBR1, TGFBR2
receptor binding (GO:0005102) 2.432TGFBR1, TGFBR2
transmembrane receptor protein kinase activity (GO:0019199) 5.322TGFBR1, TGFBR2
transmembrane receptor activity (GO:0099600) 2.532TGFBR1, TGFBR2

NET-GE enrichment

Term New enriched termICP valueGenes
protein kinase binding (GO:0019901) -3.440.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
transforming growth factor beta receptor binding (GO:0005160) -5.810.002TGFBR1, TGFBR2
cytokine binding (GO:0019955) -5.210.029TGFBR1, TGFBR2
1-phosphatidylinositol binding (GO:0005545) NEW6.740.026TGFBR1, TGFBR2
purine nucleoside binding (GO:0001883) -2.220.001MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
nucleoside phosphate binding (GO:1901265) -1.960.005MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
transforming growth factor beta binding (GO:0050431) -6.970.001TGFBR1, TGFBR2
anion binding (GO:0043168) NEW4.170.008MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
actin binding (GO:0003779) -3.740.002MYLK, TGFBR1, MYH11, PRKG1, ACTA2
kinase binding (GO:0019900) -3.320.001MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
growth factor binding (GO:0019838) -4.890.001TGFBR1, MYH11, TGFBR2, PRKG1
purine ribonucleoside triphosphate binding (GO:0035639) -2.220.001MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
nucleotide binding (GO:0000166) -1.960.005MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
transmembrane receptor protein serine/threonine kinase activity (GO:0004675) -6.910.001TGFBR1, TGFBR2
protein serine/threonine kinase activity (GO:0004674) -3.640.001MYLK, TGFBR1, PRKG1, TGFBR2, ACTA2
transferase activity (GO:0016740) -1.950.037MFAP5, MYH11, PRKG1, ACTA2, TGFBR1, TGFBR2, MYLK
calcium ion binding (GO:0005509) NEW3.170.005MFAP5, MYH11, ACTA2, TGFBR1, PRKG1, MYLK
protein kinase activity (GO:0004672) -3.270.006MYLK, TGFBR1, PRKG1, TGFBR2, ACTA2
protein complex binding (GO:0032403) NEW3.090.0MFAP5, MYH11, PRKG1, ACTA2, TGFBR1, TGFBR2, MYLK
purine nucleotide binding (GO:0017076) -2.190.001MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
nucleoside binding (GO:0001882) -2.210.001MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
ATP binding (GO:0005524) -2.430.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
protein homodimerization activity (GO:0042803) NEW3.160.006MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
kinase activity (GO:0016301) -2.930.017MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
ribonucleoside binding (GO:0032549) -2.220.001MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
GTPase activator activity (GO:0005096) NEW4.110.012TGFBR1, MYH11, PRKG1, ACTA2
SMAD binding (GO:0046332) -5.450.024TGFBR1, TGFBR2
GTPase regulator activity (GO:0030695) NEW4.010.03TGFBR1, MYH11, PRKG1, ACTA2
protein phosphatase binding (GO:0019903) NEW4.930.0TGFBR1, MYH11, TGFBR2, ACTA2
phosphatase binding (GO:0019902) NEW4.630.002TGFBR1, MYH11, TGFBR2, ACTA2
type I transforming growth factor beta receptor binding (GO:0034713) NEW7.440.004TGFBR1, TGFBR2
nucleoside-triphosphatase regulator activity (GO:0060589) NEW3.920.045TGFBR1, MYH11, PRKG1, ACTA2
small molecule binding (GO:0036094) -1.890.009MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
phosphotransferase activity, alcohol group as acceptor (GO:0016773) -3.080.011MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
transferase activity, transferring phosphorus-containing groups (GO:0016772) -2.770.017MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
adenyl nucleotide binding (GO:0030554) -2.40.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
transforming growth factor beta-activated receptor activity (GO:0005024) -7.440.001TGFBR1, TGFBR2
carbohydrate derivative binding (GO:0097367) -2.030.003MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
adenyl ribonucleotide binding (GO:0032559) -2.410.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
receptor signaling protein serine/threonine kinase activity (GO:0004702) -5.230.018TGFBR1, TGFBR2
purine ribonucleotide binding (GO:0032555) -2.20.001MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
transmembrane receptor protein kinase activity (GO:0019199) -5.320.042TGFBR1, TGFBR2
purine ribonucleoside binding (GO:0032550) -2.220.001MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
ribonucleotide binding (GO:0032553) -2.190.001MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism developmental process (GO:0044767) 1.497MFAP5, MYH11, PRKG1, ACTA2, TGFBR1, TGFBR2, MYLK
developmental process (GO:0032502) 1.367MFAP5, MYH11, PRKG1, ACTA2, TGFBR1, TGFBR2, MYLK
cellular process (GO:0009987) 0.267MFAP5, MYH11, PRKG1, ACTA2, TGFBR1, TGFBR2, MYLK
single-organism cellular process (GO:0044763) 0.657MFAP5, MYH11, PRKG1, ACTA2, TGFBR1, TGFBR2, MYLK
single-organism process (GO:0044699) 0.487MFAP5, MYH11, PRKG1, ACTA2, TGFBR1, TGFBR2, MYLK
multicellular organismal process (GO:0032501) 1.456MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
anatomical structure development (GO:0048856) 1.586MFAP5, MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1
biological regulation (GO:0065007) 0.395MYLK, TGFBR1, PRKG1, TGFBR2, ACTA2
regulation of biological process (GO:0050789) 0.455MYLK, TGFBR1, PRKG1, TGFBR2, ACTA2
cellular component organization or biogenesis (GO:0071840) 1.225MYLK, TGFBR1, MYH11, MFAP5, PRKG1
cellular component organization (GO:0016043) 1.245MYLK, TGFBR1, MYH11, MFAP5, PRKG1
phosphorylation (GO:0016310) 2.634MYLK, TGFBR1, PRKG1, TGFBR2
regulation of response to stimulus (GO:0048583) 1.544MYLK, TGFBR1, PRKG1, TGFBR2
muscle system process (GO:0003012) 4.184MYLK, MYH11, PRKG1, ACTA2
cellular protein metabolic process (GO:0044267) 1.634MYLK, TGFBR1, PRKG1, TGFBR2
cellular macromolecule metabolic process (GO:0044260) 0.934MYLK, TGFBR1, PRKG1, TGFBR2
cellular developmental process (GO:0048869) 1.824TGFBR1, MYH11, TGFBR2, ACTA2
organic substance metabolic process (GO:0071704) 0.634MYLK, TGFBR1, PRKG1, TGFBR2
positive regulation of biological process (GO:0048518) 1.24MYLK, TGFBR1, TGFBR2, ACTA2
protein phosphorylation (GO:0006468) 2.894MYLK, TGFBR1, PRKG1, TGFBR2
cellular protein modification process (GO:0006464) 1.794MYLK, TGFBR1, PRKG1, TGFBR2
regulation of cellular process (GO:0050794) 0.54MYLK, TGFBR1, PRKG1, TGFBR2
macromolecule modification (GO:0043412) 1.734MYLK, TGFBR1, PRKG1, TGFBR2
protein modification process (GO:0036211) 1.794MYLK, TGFBR1, PRKG1, TGFBR2
metabolic process (GO:0008152) 0.584MYLK, TGFBR1, PRKG1, TGFBR2
system process (GO:0003008) 2.34MYLK, MYH11, PRKG1, ACTA2
primary metabolic process (GO:0044238) 0.694MYLK, TGFBR1, PRKG1, TGFBR2
protein metabolic process (GO:0019538) 1.454MYLK, TGFBR1, PRKG1, TGFBR2
response to stimulus (GO:0050896) 1.224MYLK, TGFBR1, TGFBR2, ACTA2
cellular metabolic process (GO:0044237) 0.694MYLK, TGFBR1, PRKG1, TGFBR2
macromolecule metabolic process (GO:0043170) 0.834MYLK, TGFBR1, PRKG1, TGFBR2
phosphate-containing compound metabolic process (GO:0006796) 2.164MYLK, TGFBR1, PRKG1, TGFBR2
phosphorus metabolic process (GO:0006793) 2.154MYLK, TGFBR1, PRKG1, TGFBR2
positive regulation of metabolic process (GO:0009893) 1.743TGFBR1, TGFBR2, ACTA2
regulation of metabolic process (GO:0019222) 1.023TGFBR1, TGFBR2, ACTA2
regulation of response to external stimulus (GO:0032101) 3.063MYLK, PRKG1, TGFBR2
negative regulation of response to stimulus (GO:0048585) 2.523TGFBR1, PRKG1, TGFBR2
positive regulation of response to stimulus (GO:0048584) 2.183TGFBR1, MYLK, TGFBR2
macroautophagy (GO:0016236) 4.33MYH11, MYLK, PRKG1
organelle disassembly (GO:1903008) 4.523MYH11, MYLK, PRKG1
mitophagy in response to mitochondrial depolarization (GO:0098779) 4.853MYH11, MYLK, PRKG1
regulation of wound healing (GO:0061041) 4.883MYLK, PRKG1, TGFBR2
signal transduction (GO:0007165) 1.283TGFBR1, PRKG1, TGFBR2
anatomical structure morphogenesis (GO:0009653) 2.533TGFBR1, MYLK, TGFBR2
mitochondrion organization (GO:0007005) 3.693MYH11, MYLK, PRKG1
positive regulation of macromolecule metabolic process (GO:0010604) 1.813TGFBR1, TGFBR2, ACTA2
negative regulation of multicellular organismal process (GO:0051241) 2.843TGFBR1, PRKG1, TGFBR2
regulation of macromolecule metabolic process (GO:0060255) 1.083TGFBR1, TGFBR2, ACTA2
animal organ development (GO:0048513) 2.533TGFBR1, MFAP5, TGFBR2
extracellular structure organization (GO:0043062) 4.03MFAP5, MYH11, TGFBR1
negative regulation of biological process (GO:0048519) 1.333TGFBR1, PRKG1, TGFBR2
regulation of molecular function (GO:0065009) 1.783TGFBR1, PRKG1, TGFBR2
regulation of response to wounding (GO:1903034) 4.743MYLK, PRKG1, TGFBR2
regulation of gene expression (GO:0010468) 1.373TGFBR1, TGFBR2, ACTA2
anatomical structure formation involved in morphogenesis (GO:0048646) 3.013TGFBR1, MYH11, TGFBR2
positive regulation of cell migration (GO:0030335) 3.773TGFBR1, MYLK, TGFBR2
regulation of cell migration (GO:0030334) 3.233TGFBR1, MYLK, TGFBR2
muscle contraction (GO:0006936) 4.373MYH11, MYLK, ACTA2
mitochondrion disassembly (GO:0061726) 4.633MYH11, MYLK, PRKG1
smooth muscle contraction (GO:0006939) 5.93MYH11, MYLK, ACTA2
autophagy (GO:0006914) 3.823MYH11, MYLK, PRKG1
regulation of catalytic activity (GO:0050790) 1.973TGFBR1, PRKG1, TGFBR2
response to stress (GO:0006950) 1.83TGFBR1, MYLK, TGFBR2
regulation of cellular component movement (GO:0051270) 3.083TGFBR1, MYLK, TGFBR2
cellular component disassembly (GO:0022411) 3.523MYH11, MYLK, PRKG1
regulation of multicellular organismal process (GO:0051239) 1.873TGFBR1, PRKG1, TGFBR2
regulation of localization (GO:0032879) 1.943TGFBR1, MYLK, TGFBR2
hematopoietic or lymphoid organ development (GO:0048534) 4.493TGFBR1, MFAP5, TGFBR2
organelle organization (GO:0006996) 2.023MYH11, MYLK, PRKG1
positive regulation of cellular component movement (GO:0051272) 3.713TGFBR1, MYLK, TGFBR2
regulation of locomotion (GO:0040012) 3.123TGFBR1, MYLK, TGFBR2
single-multicellular organism process (GO:0044707) 1.783TGFBR1, TGFBR2, ACTA2
positive regulation of locomotion (GO:0040017) 3.713TGFBR1, MYLK, TGFBR2
macromitophagy (GO:0000423) 4.853MYH11, MYLK, PRKG1
regulation of response to stress (GO:0080134) 2.533MYLK, PRKG1, TGFBR2
single-organism organelle organization (GO:1902589) 2.683MYH11, MYLK, PRKG1
extracellular matrix organization (GO:0030198) 4.013TGFBR1, MYH11, MFAP5
regulation of cell motility (GO:2000145) 3.163TGFBR1, MYLK, TGFBR2
positive regulation of cell motility (GO:2000147) 3.743TGFBR1, MYLK, TGFBR2
mitophagy (GO:0000422) 4.633MYH11, MYLK, PRKG1
negative regulation of cellular process (GO:0048523) 1.413TGFBR1, PRKG1, TGFBR2
positive regulation of cellular process (GO:0048522) 1.33TGFBR1, MYLK, TGFBR2
regulation of phosphate metabolic process (GO:0019220) 2.352TGFBR1, TGFBR2
regulation of primary metabolic process (GO:0080090) 1.082TGFBR1, TGFBR2
regulation of transport (GO:0051049) 2.242TGFBR1, MYLK
cell development (GO:0048468) 3.282MYH11, ACTA2
activation of protein kinase activity (GO:0032147) 4.082TGFBR1, TGFBR2
macromolecular complex subunit organization (GO:0043933) 2.142TGFBR1, MYH11
cell surface receptor signaling pathway (GO:0007166) 2.092TGFBR1, TGFBR2
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242TGFBR1, TGFBR2
signal transduction by protein phosphorylation (GO:0023014) 3.792TGFBR1, TGFBR2
cellular response to stimulus (GO:0051716) 1.972TGFBR1, MYLK
response to cholesterol (GO:0070723) 6.682TGFBR1, TGFBR2
negative regulation of signal transduction (GO:0009968) 2.752TGFBR1, TGFBR2
regulation of signal transduction (GO:0009966) 1.842TGFBR1, TGFBR2
response to wounding (GO:0009611) 4.392TGFBR1, TGFBR2
peptidyl-threonine modification (GO:0018210) 5.922TGFBR1, TGFBR2
negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512) 5.542TGFBR1, TGFBR2
positive regulation of molecular function (GO:0044093) 2.232TGFBR1, TGFBR2
regulation of cell proliferation (GO:0042127) 2.412TGFBR1, TGFBR2
positive regulation of transport (GO:0051050) 2.92TGFBR1, MYLK
regulation of protein kinase activity (GO:0045859) 3.152TGFBR1, TGFBR2
response to organic substance (GO:0010033) 2.22TGFBR1, TGFBR2
transforming growth factor beta receptor signaling pathway (GO:0007179) 5.192TGFBR1, TGFBR2
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 4.62TGFBR1, TGFBR2
regulation of phosphorylation (GO:0042325) 2.52TGFBR1, TGFBR2
positive regulation of phosphorylation (GO:0042327) 2.92TGFBR1, TGFBR2
single organism reproductive process (GO:0044702) 2.732TGFBR1, TGFBR2
peptidyl-serine modification (GO:0018209) 4.722TGFBR1, TGFBR2
response to external stimulus (GO:0009605) 2.552TGFBR2, ACTA2
cell motility (GO:0048870) 3.022TGFBR1, PRKG1
embryo development ending in birth or egg hatching (GO:0009792) 4.352TGFBR1, TGFBR2
negative regulation of cell communication (GO:0010648) 2.662TGFBR1, TGFBR2
regulation of cell morphogenesis (GO:0022604) 3.42TGFBR1, TGFBR2
positive regulation of cellular component organization (GO:0051130) 2.682TGFBR1, TGFBR2
embryonic organ morphogenesis (GO:0048562) 4.922TGFBR1, TGFBR2
regulation of anatomical structure morphogenesis (GO:0022603) 2.792TGFBR1, TGFBR2
movement of cell or subcellular component (GO:0006928) 2.612TGFBR1, PRKG1
positive regulation of gene expression (GO:0010628) 2.352TGFBR1, ACTA2
intracellular signal transduction (GO:0035556) 2.392TGFBR1, PRKG1
positive regulation of transferase activity (GO:0051347) 3.312TGFBR1, TGFBR2
actin filament-based process (GO:0030029) 3.942MYH11, PRKG1
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090101) 5.12TGFBR1, TGFBR2
pathway-restricted SMAD protein phosphorylation (GO:0060389) 7.162TGFBR1, TGFBR2
regulation of kinase activity (GO:0043549) 3.072TGFBR1, TGFBR2
regulation of immune system process (GO:0002682) 2.52MYLK, TGFBR2
positive regulation of catalytic activity (GO:0043085) 2.42TGFBR1, TGFBR2
cell migration (GO:0016477) 3.122TGFBR1, PRKG1
skeletal system morphogenesis (GO:0048705) 4.982TGFBR1, TGFBR2
embryonic skeletal system morphogenesis (GO:0048704) 5.312TGFBR1, TGFBR2
organ morphogenesis (GO:0009887) 3.552TGFBR1, TGFBR2
embryonic cranial skeleton morphogenesis (GO:0048701) 6.22TGFBR1, TGFBR2
regulation of developmental process (GO:0050793) 2.12TGFBR1, TGFBR2
regulation of transforming growth factor beta receptor signaling pathway (GO:0017015) 5.132TGFBR1, TGFBR2
single-organism metabolic process (GO:0044710) 1.632TGFBR1, TGFBR2
wound healing (GO:0042060) 5.132TGFBR1, TGFBR2
programmed cell death (GO:0012501) 3.12TGFBR1, TGFBR2
cell activation (GO:0001775) 3.472TGFBR1, TGFBR2
regulation of epithelial to mesenchymal transition (GO:0010717) 5.552TGFBR1, TGFBR2
positive regulation of protein modification process (GO:0031401) 2.72TGFBR1, TGFBR2
regulation of transferase activity (GO:0051338) 2.882TGFBR1, TGFBR2
response to alcohol (GO:0097305) 4.582TGFBR1, TGFBR2
regulation of cell adhesion (GO:0030155) 3.272PRKG1, TGFBR2
cell differentiation (GO:0030154) 2.142TGFBR1, TGFBR2
regulation of cellular component organization (GO:0051128) 2.012TGFBR1, TGFBR2
negative regulation of signaling (GO:0023057) 2.652TGFBR1, TGFBR2
cellular component assembly (GO:0022607) 2.142MYH11, MYLK
peptidyl-amino acid modification (GO:0018193) 2.982TGFBR1, TGFBR2
regulation of signaling (GO:0023051) 1.722TGFBR1, TGFBR2
regulation of cell communication (GO:0010646) 1.732TGFBR1, TGFBR2
response to organic cyclic compound (GO:0014070) 3.072TGFBR1, TGFBR2
response to endogenous stimulus (GO:0009719) 2.792TGFBR1, TGFBR2
regulation of cellular response to growth factor stimulus (GO:0090287) 4.292TGFBR1, TGFBR2
in utero embryonic development (GO:0001701) 4.42TGFBR1, TGFBR2
positive regulation of phosphorus metabolic process (GO:0010562) 2.782TGFBR1, TGFBR2
positive regulation of kinase activity (GO:0033674) 3.542TGFBR1, TGFBR2
regulation of protein metabolic process (GO:0051246) 1.932TGFBR1, TGFBR2
positive regulation of protein metabolic process (GO:0051247) 2.432TGFBR1, TGFBR2
regulation of cell development (GO:0060284) 3.012TGFBR1, TGFBR2
regulation of cell activation (GO:0050865) 3.532PRKG1, TGFBR2
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.912TGFBR1, TGFBR2
positive regulation of cellular protein metabolic process (GO:0032270) 2.492TGFBR1, TGFBR2
regulation of protein modification process (GO:0031399) 2.322TGFBR1, TGFBR2
chordate embryonic development (GO:0043009) 4.382TGFBR1, TGFBR2
positive regulation of response to wounding (GO:1903036) 5.762MYLK, TGFBR2
positive regulation of cell proliferation (GO:0008284) 3.012TGFBR1, TGFBR2
negative regulation of cell proliferation (GO:0008285) 3.262TGFBR1, TGFBR2
response to abiotic stimulus (GO:0009628) 2.82MYLK, TGFBR2
regulation of cell differentiation (GO:0045595) 2.422TGFBR1, TGFBR2
locomotion (GO:0040011) 2.912TGFBR1, PRKG1
negative regulation of developmental process (GO:0051093) 3.172TGFBR1, TGFBR2
regulation of cellular protein metabolic process (GO:0032268) 1.992TGFBR1, TGFBR2
negative regulation of cellular response to growth factor stimulus (GO:0090288) 4.922TGFBR1, TGFBR2
regulation of biological quality (GO:0065008) 1.682PRKG1, ACTA2
hemopoiesis (GO:0030097) 5.072MFAP5, TGFBR2
positive regulation of protein kinase activity (GO:0045860) 3.612TGFBR1, TGFBR2
embryo development (GO:0009790) 4.22TGFBR1, TGFBR2
peptidyl-threonine phosphorylation (GO:0018107) 6.022TGFBR1, TGFBR2
peptidyl-serine phosphorylation (GO:0018105) 4.822TGFBR1, TGFBR2
positive regulation of growth (GO:0045927) 4.252TGFBR1, TGFBR2
cell projection organization (GO:0030030) 3.142MYLK, PRKG1
positive regulation of cellular metabolic process (GO:0031325) 1.812TGFBR1, TGFBR2
regulation of cellular metabolic process (GO:0031323) 1.072TGFBR1, TGFBR2
actin cytoskeleton organization (GO:0030036) 4.12MYH11, PRKG1
palate development (GO:0060021) 5.382TGFBR1, TGFBR2
regulation of cell-cell adhesion (GO:0022407) 3.792PRKG1, TGFBR2
positive regulation of wound healing (GO:0090303) 5.882MYLK, TGFBR2
lens development in camera-type eye (GO:0002088) 6.092TGFBR1, TGFBR2
cell death (GO:0008219) 3.052TGFBR1, TGFBR2
multicellular organism development (GO:0007275) 2.542TGFBR1, TGFBR2
pattern specification process (GO:0007389) 3.792TGFBR1, TGFBR2
negative regulation of cellular response to transforming growth factor beta stimulus (GO:1903845) 5.542TGFBR1, TGFBR2
regulation of cellular response to transforming growth factor beta stimulus (GO:1903844) 5.132TGFBR1, TGFBR2
protein complex subunit organization (GO:0071822) 2.62TGFBR1, MYH11
response to lipid (GO:0033993) 3.112TGFBR1, TGFBR2
regulation of growth (GO:0040008) 3.262TGFBR1, TGFBR2
tissue morphogenesis (GO:0048729) 3.872MYLK, TGFBR2
embryonic morphogenesis (GO:0048598) 3.722TGFBR1, TGFBR2
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.392TGFBR1, TGFBR2
positive regulation of phosphate metabolic process (GO:0045937) 2.782TGFBR1, TGFBR2
apoptotic process (GO:0006915) 3.142TGFBR1, TGFBR2
regulation of phosphorus metabolic process (GO:0051174) 2.352TGFBR1, TGFBR2
reproductive process (GO:0022414) 2.552TGFBR1, TGFBR2
response to chemical (GO:0042221) 1.982TGFBR1, TGFBR2
response to sterol (GO:0036314) 6.552TGFBR1, TGFBR2
response to oxygen-containing compound (GO:1901700) 2.572TGFBR1, TGFBR2
heart development (GO:0007507) 4.242TGFBR1, TGFBR2
cytoskeleton organization (GO:0007010) 3.222MYH11, PRKG1
regulation of multicellular organismal development (GO:2000026) 2.312TGFBR1, TGFBR2
regulation of protein phosphorylation (GO:0001932) 2.572TGFBR1, TGFBR2
positive regulation of protein phosphorylation (GO:0001934) 2.952TGFBR1, TGFBR2

NET-GE enrichment

Term New enriched termICP valueGenes
actomyosin structure organization (GO:0031032) NEW5.40.0MYLK, TGFBR1, PRKG1, TGFBR2
negative regulation of cell growth (GO:0030308) NEW4.580.035MYLK, TGFBR1, PRKG1, TGFBR2
positive regulation of organelle organization (GO:0010638) NEW3.380.027TGFBR2, TGFBR1, MYH11, PRKG1, ACTA2
regulation of cell adhesion (GO:0030155) -3.270.021MYLK, TGFBR1, PRKG1, TGFBR2, ACTA2
cellular response to oxygen-containing compound (GO:1901701) NEW3.220.029MFAP5, MYH11, TGFBR2, TGFBR1, PRKG1, MYLK
organ morphogenesis (GO:0009887) -3.550.003MFAP5, MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1
actin cytoskeleton organization (GO:0030036) -4.10.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) -4.390.036TGFBR1, MYH11, PRKG1, TGFBR2
muscle system process (GO:0003012) -4.180.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
regulation of striated muscle contraction (GO:0006942) NEW5.380.0TGFBR1, MYH11, TGFBR2, PRKG1
cell migration (GO:0016477) -3.120.033MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
enzyme linked receptor protein signaling pathway (GO:0007167) -3.240.03MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
lens development in camera-type eye (GO:0002088) -6.090.025TGFBR1, TGFBR2
regulation of cell projection organization (GO:0031344) NEW3.380.002MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
positive regulation of cell projection organization (GO:0031346) NEW3.990.004MYLK, TGFBR1, MYH11, TGFBR2, ACTA2
regulation of wound healing (GO:0061041) -4.880.003MYLK, PRKG1, TGFBR2
regulation of blood vessel size (GO:0050880) NEW4.80.033MYH11, PRKG1, ACTA2
cell growth (GO:0016049) NEW4.830.012TGFBR1, MYH11, TGFBR2, ACTA2
actin filament-based process (GO:0030029) -3.940.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
regulation of system process (GO:0044057) NEW3.530.029TGFBR2, TGFBR1, MYH11, MYLK, PRKG1
pathway-restricted SMAD protein phosphorylation (GO:0060389) -7.160.027TGFBR1, TGFBR2
regulation of muscle contraction (GO:0006937) NEW4.750.0MYLK, TGFBR1, MYH11, PRKG1, TGFBR2
regulation of cytoskeleton organization (GO:0051493) NEW3.720.026MYLK, TGFBR1, PRKG1, TGFBR2, ACTA2
response to growth factor (GO:0070848) NEW4.140.009MFAP5, MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1
response to mechanical stimulus (GO:0009612) NEW4.410.042MYLK, TGFBR1, PRKG1, TGFBR2
protein autophosphorylation (GO:0046777) NEW4.460.014MYLK, TGFBR1, PRKG1, ACTA2
positive regulation of apoptotic process (GO:0043065) NEW3.380.047TGFBR1, PRKG1, MYH11, TGFBR2, ACTA2
positive regulation of cell development (GO:0010720) NEW3.570.006TGFBR1, PRKG1, MYH11, TGFBR2, ACTA2
biological adhesion (GO:0022610) NEW2.810.041MFAP5, MYH11, ACTA2, TGFBR1, TGFBR2, MYLK
circulatory system process (GO:0003013) NEW4.380.012TGFBR2, MYH11, PRKG1, ACTA2
regulation of tube size (GO:0035150) NEW4.790.04MYH11, PRKG1, ACTA2
positive regulation of cell migration (GO:0030335) -3.770.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
single organism reproductive process (GO:0044702) -2.730.007MFAP5, MYH11, PRKG1, ACTA2, TGFBR1, TGFBR2, MYLK
embryonic cranial skeleton morphogenesis (GO:0048701) -6.20.027TGFBR1, TGFBR2
tissue morphogenesis (GO:0048729) -3.870.029MYLK, TGFBR1, MYH11, TGFBR2, ACTA2
muscle contraction (GO:0006936) -4.370.048MYLK, MYH11, PRKG1, ACTA2
positive regulation of cellular component movement (GO:0051272) -3.710.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
smooth muscle contraction (GO:0006939) -5.90.013MYH11, MYLK, ACTA2
regulation of actin filament-based process (GO:0032970) NEW3.970.006MYLK, TGFBR1, PRKG1, TGFBR2, ACTA2
tissue development (GO:0009888) NEW3.270.034MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
positive regulation of MAPK cascade (GO:0043410) NEW3.570.023TGFBR2, TGFBR1, MYH11, PRKG1, ACTA2
response to cholesterol (GO:0070723) -6.680.012TGFBR1, TGFBR2
regulation of cell growth (GO:0001558) NEW3.750.046TGFBR2, TGFBR1, MYH11, MYLK, PRKG1
sarcomere organization (GO:0045214) NEW6.40.003TGFBR1, MYLK, TGFBR2
regulation of muscle system process (GO:0090257) NEW4.510.0TGFBR2, TGFBR1, MYH11, MYLK, PRKG1
regulation of actin cytoskeleton organization (GO:0032956) NEW4.090.004MYLK, TGFBR1, PRKG1, TGFBR2, ACTA2
cell adhesion (GO:0007155) NEW2.820.041MFAP5, MYH11, ACTA2, TGFBR1, TGFBR2, MYLK
positive regulation of intracellular signal transduction (GO:1902533) NEW2.950.025MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
cellular lipid metabolic process (GO:0044255) NEW2.920.043MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
response to sterol (GO:0036314) -6.550.016TGFBR1, TGFBR2
regulation of cardiac muscle contraction (GO:0055117) NEW5.570.012TGFBR1, PRKG1, TGFBR2
negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512) -5.540.036TGFBR1, MYH11, TGFBR2
growth (GO:0040007) NEW3.80.046MYLK, TGFBR1, MYH11, TGFBR2, ACTA2
positive regulation of cell differentiation (GO:0045597) NEW3.010.028MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
positive regulation of sarcomere organization (GO:0060298) NEW8.120.008TGFBR1, TGFBR2
positive regulation of phosphorylation (GO:0042327) -2.90.048MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
actin filament organization (GO:0007015) NEW4.540.014TGFBR1, MYH11, MYLK, PRKG1
cellular response to growth factor stimulus (GO:0071363) NEW4.270.007MFAP5, MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1
positive regulation of locomotion (GO:0040017) -3.710.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
regulation of cellular component movement (GO:0051270) -3.080.015MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
negative regulation of cell adhesion (GO:0007162) NEW4.330.009MYLK, TGFBR1, PRKG1, ACTA2
regulation of sarcomere organization (GO:0060297) NEW7.650.037TGFBR1, TGFBR2
positive regulation of programmed cell death (GO:0043068) NEW3.380.048TGFBR1, PRKG1, MYH11, TGFBR2, ACTA2
regulation of cellular component biogenesis (GO:0044087) NEW3.080.005MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
positive regulation of cytoskeleton organization (GO:0051495) NEW4.580.025TGFBR1, PRKG1, TGFBR2, ACTA2
positive regulation of cell motility (GO:2000147) -3.740.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
cytoskeleton organization (GO:0007010) -3.220.009MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
regulation of growth (GO:0040008) -3.260.021MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.286MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
cytoplasmic part (GO:0044444) 0.826MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
cell part (GO:0044464) 0.116MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
cytosol (GO:0005829) 1.685MYLK, PRKG1, MYH11, TGFBR2, ACTA2
membrane-bounded organelle (GO:0043227) 0.475MYLK, TGFBR1, MYH11, PRKG1, ACTA2
intracellular organelle (GO:0043229) 0.515MYLK, TGFBR1, MYH11, PRKG1, ACTA2
organelle (GO:0043226) 0.45MYLK, TGFBR1, MYH11, PRKG1, ACTA2
protein complex (GO:0043234) 1.514TGFBR1, MYH11, TGFBR2, ACTA2
cytoplasm (GO:0005737) 1.014MYLK, PRKG1, TGFBR2, ACTA2
macromolecular complex (GO:0032991) 1.354TGFBR1, MYH11, TGFBR2, ACTA2
extracellular region part (GO:0044421) 1.574MFAP5, MYH11, MYLK, ACTA2
extracellular organelle (GO:0043230) 1.893MYH11, MYLK, ACTA2
intracellular membrane-bounded organelle (GO:0043231) 0.63TGFBR1, MYH11, PRKG1
extracellular exosome (GO:0070062) 1.893MYH11, MYLK, ACTA2
membrane (GO:0016020) 0.683TGFBR1, PRKG1, TGFBR2
membrane-bounded vesicle (GO:0031988) 1.713MYH11, MYLK, ACTA2
plasma membrane (GO:0005886) 1.393TGFBR1, PRKG1, TGFBR2
extracellular vesicle (GO:1903561) 1.893MYH11, MYLK, ACTA2
organelle part (GO:0044422) 0.793MYH11, MYLK, ACTA2
vesicle (GO:0031982) 1.643MYH11, MYLK, ACTA2
non-membrane-bounded organelle (GO:0043228) 1.762MYLK, ACTA2
intrinsic component of membrane (GO:0031224) 1.132TGFBR1, TGFBR2
cytoskeleton (GO:0005856) 2.552MYLK, ACTA2
plasma membrane protein complex (GO:0098797) 3.552TGFBR1, TGFBR2
transforming growth factor beta receptor homodimeric complex (GO:0070022) 8.422TGFBR1, TGFBR2
integral component of membrane (GO:0016021) 1.142TGFBR1, TGFBR2
plasma membrane receptor complex (GO:0098802) 4.632TGFBR1, TGFBR2
cytoskeletal part (GO:0044430) 2.492MYH11, MYLK
plasma membrane part (GO:0044459) 1.952TGFBR1, TGFBR2
catalytic complex (GO:1902494) 2.92TGFBR1, TGFBR2
transferase complex, transferring phosphorus-containing groups (GO:0061695) 4.612TGFBR1, TGFBR2
lamellipodium (GO:0030027) 4.732MYLK, ACTA2
cell surface (GO:0009986) 3.442TGFBR1, TGFBR2
membrane region (GO:0098589) 3.952TGFBR1, TGFBR2
serine/threonine protein kinase complex (GO:1902554) 5.452TGFBR1, TGFBR2
transferase complex (GO:1990234) 3.322TGFBR1, TGFBR2
cell projection (GO:0042995) 2.472MYLK, ACTA2
receptor complex (GO:0043235) 4.012TGFBR1, TGFBR2
intracellular non-membrane-bounded organelle (GO:0043232) 1.762MYLK, ACTA2
membrane raft (GO:0045121) 4.182TGFBR1, TGFBR2
intracellular organelle part (GO:0044446) 0.812MYH11, MYLK
membrane protein complex (GO:0098796) 2.842TGFBR1, TGFBR2
protein kinase complex (GO:1902911) 5.312TGFBR1, TGFBR2
membrane part (GO:0044425) 0.952TGFBR1, TGFBR2
membrane microdomain (GO:0098857) 4.172TGFBR1, TGFBR2
contractile fiber part (GO:0044449) 4.532MYH11, ACTA2

NET-GE enrichment

Term New enriched termICP valueGenes
actin filament bundle (GO:0032432) NEW5.740.01MYH11, MYLK
plasma membrane region (GO:0098590) NEW2.970.011TGFBR1, PRKG1, MYH11, TGFBR2, ACTA2
membrane-enclosed lumen (GO:0031974) NEW3.050.003MFAP5, MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1
extracellular matrix (GO:0031012) NEW3.810.001MFAP5, MYH11, TGFBR2, ACTA2, TGFBR1
side of membrane (GO:0098552) NEW4.220.024TGFBR1, MYH11, TGFBR2, PRKG1
tight junction (GO:0005923) NEW5.090.02TGFBR1, TGFBR2, ACTA2
Z disc (GO:0030018) NEW5.110.025TGFBR1, PRKG1, TGFBR2
actomyosin (GO:0042641) NEW5.660.012MYH11, MYLK
cytoskeleton (GO:0005856) -2.550.004MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
stress fiber (GO:0001725) NEW5.810.009MYH11, MYLK
extracellular space (GO:0005615) NEW2.630.002MFAP5, MYH11, PRKG1, ACTA2, TGFBR1, TGFBR2, MYLK
protein kinase complex (GO:1902911) -5.310.019TGFBR1, TGFBR2
smooth muscle contractile fiber (GO:0030485) NEW8.420.001MYH11, ACTA2
neuron part (GO:0097458) NEW2.640.023MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
cell junction (GO:0030054) NEW2.750.017MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
neuron projection (GO:0043005) NEW3.120.05MYLK, TGFBR1, MYH11, PRKG1, TGFBR2
apical plasma membrane (GO:0016324) NEW4.130.001TGFBR1, PRKG1, MYH11, TGFBR2, ACTA2
occluding junction (GO:0070160) NEW5.070.02TGFBR1, TGFBR2, ACTA2
anchoring junction (GO:0070161) NEW3.610.003TGFBR1, PRKG1, MYH11, TGFBR2, ACTA2
serine/threonine protein kinase complex (GO:1902554) -5.450.01TGFBR1, TGFBR2
cell cortex (GO:0005938) NEW4.780.041TGFBR1, PRKG1, ACTA2
cell-cell junction (GO:0005911) NEW3.850.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
receptor complex (GO:0043235) -4.010.019TGFBR1, MYH11, PRKG1, TGFBR2
organelle lumen (GO:0043233) NEW3.050.002MFAP5, MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1
membrane raft (GO:0045121) -4.180.008TGFBR1, MYH11, TGFBR2, PRKG1
intracellular organelle lumen (GO:0070013) NEW3.050.028TGFBR2, MFAP5, MYH11, TGFBR1, PRKG1
transforming growth factor beta receptor homodimeric complex (GO:0070022) -8.420.0TGFBR1, TGFBR2
contractile fiber (GO:0043292) NEW5.810.006MYH11, ACTA2
contractile fiber part (GO:0044449) -4.530.0MYH11, TGFBR2, ACTA2, TGFBR1, PRKG1, MYLK
proteinaceous extracellular matrix (GO:0005578) NEW4.010.0TGFBR2, MFAP5, MYH11, TGFBR1, ACTA2
adherens junction (GO:0005912) NEW3.660.003TGFBR1, PRKG1, MYH11, TGFBR2, ACTA2