Disease table of LEUKODYSTROPHY, HYPOMYELINATING OMIM ID: PS312080

Gene-disease associations table

Gene	Associated with LEUKODYSTROPHY, HYPOMYELINATING in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TUBB4A	ClinVar, OMIM, HUMSAVAR	HGNC link	19p13.3	2	PS128100, PS312080
POLR3A	ClinVar, OMIM, HUMSAVAR	HGNC link	10q22.3	1	PS312080
GJC2	ClinVar, OMIM, HUMSAVAR	HGNC link	1q42.13	3	PS153100, PS312080, PS303350
HIKESHI	ClinVar, OMIM	HGNC link	11q14.2	1	PS312080
VPS11	ClinVar, OMIM	HGNC link	11q23.3	1	PS312080
AIMP1	ClinVar, OMIM	HGNC link	4q24	1	PS312080
HSPD1	ClinVar, OMIM, HUMSAVAR	HGNC link	2q33.1	2	PS312080, PS303350
RARS	ClinVar, OMIM, HUMSAVAR	HGNC link	5q34	1	PS312080
POLR1C	ClinVar, OMIM, HUMSAVAR	HGNC link	6p21.1	2	PS154500, PS312080
POLR3B	ClinVar, OMIM, HUMSAVAR	HGNC link	12q23.3	1	PS312080
PYCR2	ClinVar, OMIM, HUMSAVAR	HGNC link	1q42.12	1	PS312080
PLP1	ClinVar, OMIM, HUMSAVAR	HGNC link	Xq22.2	2	PS312080, PS303350
FAM126A	ClinVar, OMIM, HUMSAVAR	HGNC link	7p15.3	1	PS312080

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
1q42	2	GJC2, PYCR2

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
1q4	2	GJC2, PYCR2

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1q	2	GJC2, PYCR2
11q	2	VPS11, HIKESHI

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	2	VPS11, HIKESHI
1	2	GJC2, PYCR2

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
GJC2	YES	1	SOX10	0
HSPD1	YES	1	RUNX3	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TUBB4A	AIMP1	No	1	CUL1
TUBB4A	HSPD1	No	12	ASB4, METTL20, MCM2, METTL21B, TUBA1C, GAN, CUL3, FBXO6, SNW1, UBL4A, HSPA5, CUL1
TUBB4A	RARS	No	7	NF2, EGFR, CUL1, FBXO6, TUBGCP2, MCM2, CUL3
TUBB4A	POLR1C	No	3	ARRB2, CUL3, TNFAIP1
TUBB4A	POLR3B	No	1	RUVBL1
TUBB4A	PYCR2	No	3	NF2, CUL3, EGFR
TUBB4A	PLP1	No	1	CLN8
TUBB4A	FAM126A	No	1	GAN
POLR3A	VPS11	No	2	NTRK1, VPS18
POLR3A	AIMP1	No	1	NTRK1
POLR3A	HSPD1	No	4	NTRK1, HDAC1, RPAP1, PPP2R2C
POLR3A	RARS	No	1	NTRK1
POLR3A	POLR1C	Yes	19	POLR1D, POLR3D, CRCP, TSR1, POLR3C, POLR3H, POLR3G, POLR3K, POLR1A, SMARCA5, POLR2F, POLR1B, POLR3F, POLR3E, POLR3B, NTRK1, POLR2E, POLR2H, GPN3
POLR3A	POLR3B	Yes	32	CRCP, POLR3G, MAF1, GPN1, POLR3D, RPAP1, POLR3F, POLR2H, POLR2F, POLR1C, RAE1, POLR3E, POLR3C, IPO9, PPP1CC, GPN3, RPAP2, SKAP1, TSR1, SMARCA5, POLR3K, MRPL17, POLR2A, POLR3H, POLR1A, PPP1CA, POLR1B, PIH1D1, NTRK1, POLR2E, POLR1D, LOC101060521
POLR3A	PYCR2	No	1	NTRK1
VPS11	AIMP1	No	1	NTRK1
VPS11	HSPD1	No	5	NTRK1, KRTAP10-3, KRTAP10-8, NXF1, MOV10
VPS11	RARS	No	1	NTRK1
VPS11	POLR1C	No	1	NTRK1
VPS11	POLR3B	No	3	NTRK1, NXF1, MOV10
VPS11	PYCR2	No	1	NTRK1
AIMP1	HSPD1	No	7	CUL1, PAN2, UBC, COPS5, APP, NTRK1, CCAR2
AIMP1	RARS	Yes	21	COMTD1, IARS, DARS, GAG, CCAR2, CUL1, RPLP0, EEF1E1, MARS, EPRS, DNAJA1, UBC, QARS, AIMP2, LARS, EIF2S3, NTRK1, EEF1A1, SDCBP, KARS, SDCCAG8
AIMP1	POLR1C	No	2	NTRK1, UBC
AIMP1	POLR3B	No	1	NTRK1
AIMP1	PYCR2	No	2	NTRK1, APP
HSPD1	RARS	No	13	STAU1, CUL1, MCM2, CUL3, VCAM1, CCDC8, UBC, GRB2, FBXO6, NTRK1, MYC, HDAC5, CCAR2
HSPD1	POLR1C	No	7	FN1, CLU, UBC, CUL3, NTRK1, C1QBP, LZTS2
HSPD1	POLR3B	No	4	NTRK1, NXF1, RPAP1, MOV10
HSPD1	PYCR2	No	6	ICT1, EBNA-LP, VCAM1, APP, NTRK1, CUL3
HSPD1	FAM126A	No	1	GAN
RARS	POLR1C	No	3	NTRK1, UBC, CUL3
RARS	POLR3B	No	1	NTRK1
RARS	PYCR2	No	5	NTRK1, NF2, VCAM1, EGFR, CUL3
POLR1C	POLR3B	Yes	19	SMARCA5, POLR1B, TSR1, CRCP, POLR3H, POLR3G, POLR3E, POLR3K, POLR2F, POLR3D, POLR3C, POLR3F, POLR3A, NTRK1, POLR1A, POLR2E, POLR2H, POLR1D, GPN3
POLR1C	PYCR2	No	2	NTRK1, CUL3
POLR3B	PYCR2	No	1	NTRK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
HSPD1	POLR3B	No	1	KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
TUBB4A	POLR3A	No	-	2	UBC, CDK1
TUBB4A	AIMP1	No	-	2	UBC, CDK1
TUBB4A	HSPD1	No	-	2	UBC, TCP1
TUBB4A	RARS	No	-	1	UBC
TUBB4A	POLR1C	No	-	1	UBC
TUBB4A	POLR3B	No	-	1	UBC
TUBB4A	PYCR2	No	-	1	UBC
POLR3A	AIMP1	No	-	2	UBC, CDK1
POLR3A	HSPD1	No	-	1	UBC
POLR3A	RARS	No	-	2	UBC, CDK7
POLR3A	POLR1C	Yes	binding	46	GTF3C3, SSB, NFIX, CRCP, TBP, POLR2J, POLR3G, NFIB, SNAPC2, MAF1, POLR3H, POLR2L, POLR3F, GTF3A, POLR2F, POLR2H, NFIA, POU2F1, GTF3C1, SNAPC5, POLR3D, POLR3E, POLR2B, POLR3B, POLR3GL, SNAPC1, GTF3C2, ZNF143, NFIC, GTF3C5, BRF1, POLR2G, SNAPC3, GTF3C4, SUPT5H, POLR3K, BRF2, POLR2D, POLR1B, LZTS1, BDP1, UBC, POLR2E, SNAPC4, POLR1D, POLR2K
POLR3A	POLR3B	Yes	binding	45	NFIB, SSB, NFIX, CRCP, TBP, POLR3G, GTF3C3, SNAPC2, POLR3H, RAE1, POLR2L, POLR3F, GTF3A, POLR2F, POLR2H, NFIA, POU2F1, POLR1C, SNAPC5, POLR3D, POLR3E, POLR2C, POLR3GL, SNAPC1, GTF3C2, ZNF143, NFIC, GTF3C5, BRF1, POLR2E, SNAPC3, GTF3C4, UBB, SUPT5H, POLR3K, BRF2, MAF1, LZTS1, BDP1, GTF3C1, UBC, POLR2G, SNAPC4, POLR1D, POLR2K
POLR3A	PYCR2	No	-	1	UBC
AIMP1	HSPD1	Yes	binding	2	UBC, FARS2
AIMP1	RARS	Yes	binding	13	MARS2, IARS, DARS, MAPK8, QARS, EEF1E1, MARS, IARS2, LARS, UBC, EPRS, KARS, AIMP2
AIMP1	POLR1C	No	-	1	UBC
AIMP1	POLR3B	No	-	1	UBC
AIMP1	PYCR2	No	-	1	UBC
HSPD1	RARS	No	-	2	UBC, AIMP1
HSPD1	POLR1C	No	-	1	UBC
HSPD1	POLR3B	No	-	1	UBC
HSPD1	PYCR2	No	-	1	UBC
RARS	POLR1C	No	-	2	UBC, CCNH
RARS	POLR3B	No	-	1	UBC
RARS	PYCR2	No	-	1	UBC
POLR1C	POLR3B	Yes	binding	46	NFIB, SSB, NFIX, CRCP, TBP, NME1, POLR3G, GTF3C3, SNAPC2, MAF1, POLR3H, POLR2L, POLR1A, GTF3A, POLR2F, POLR2H, NFIA, POU2F1, GTF3C2, GTF3C1, SNAPC5, POLR3E, POLR3D, POLR3GL, SNAPC1, RRN3, POLR3K, ZNF143, NFIC, POLR3A, BRF1, POLR2G, SNAPC3, GTF3C4, SUPT5H, GTF3C5, BRF2, POLR2A, POLR3F, LZTS1, BDP1, UBC, POLR2E, SNAPC4, POLR1D, POLR2K
POLR1C	PYCR2	No	-	1	UBC
POLR3B	PYCR2	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
AIMP1	RARS	Yes	Multisynthetase complex	9	EEF1E1, IARS, DARS, QARS, MARS, LARS, EPRS, KARS, AIMP2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
POLR3A	POLR1C	Yes	7	CRCP, POLR3H, POLR1A, POLR3C, POLR3B, POLR2H, POLR2E
POLR3A	POLR3B	Yes	6	CRCP, POLR1C, POLR3H, POLR3D, POLR2H, POLR1D
AIMP1	RARS	Yes	9	EEF1E1, IARS, DARS, QARS, MARS, LARS, EPRS, KARS, AIMP2
POLR1C	POLR3B	Yes	5	POLR3A, POLR3H, POLR2H, CRCP, TSR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
AIMP1	RARS	Yes	3	AIMP1, QARS, RARS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Metabolic pathways	hsa01100	2.49	4	PYCR2, POLR1C, POLR3A, POLR3B
Purine metabolism	hsa00230	5.28	3	POLR1C, POLR3A, POLR3B
RNA polymerase	hsa03020	7.77	3	POLR1C, POLR3A, POLR3B
Epstein-Barr virus infection	hsa05169	4.97	3	POLR1C, POLR3A, POLR3B
Pyrimidine metabolism	hsa00240	6.01	3	POLR1C, POLR3A, POLR3B
Cytosolic DNA-sensing pathway	hsa04623	6.79	3	POLR1C, POLR3A, POLR3B

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Aminoacyl-tRNA biosynthesis (hsa00970)	NEW	7.31	0.004	HSPD1, AIMP1, RARS
Cytosolic DNA-sensing pathway (hsa04623)	-	6.79	0.001	POLR1C, POLR3A, POLR3B
Nucleotide metabolism	NEW	5.05	0.029	POLR1C, POLR3A, POLR3B
RNA polymerase (hsa03020)	-	7.77	0.0	POLR1C, POLR3A, POLR3B
Transcription	NEW	5.07	0.028	POLR1C, POLR3A, POLR3B
Epstein-Barr virus infection (hsa05169)	-	4.97	0.035	POLR1C, POLR3A, POLR3B
Purine metabolism (hsa00230)	-	5.28	0.018	HSPD1, POLR1C, POLR3A, POLR3B
Pyrimidine metabolism (hsa00240)	-	6.01	0.003	HSPD1, POLR1C, POLR3A, POLR3B

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Gene Expression	R-HSA-74160	2.72	5	POLR3A, POLR1C, AIMP1, RARS, POLR3B
Immune System	R-HSA-168256	2.37	4	POLR3A, TUBB4A, POLR1C, POLR3B
RNA Polymerase III Transcription Initiation	R-HSA-76046	7.85	3	POLR1C, POLR3A, POLR3B
RNA Polymerase III Chain Elongation	R-HSA-73780	8.81	3	POLR1C, POLR3A, POLR3B
Innate Immune System	R-HSA-168249	3.17	3	POLR1C, POLR3A, POLR3B
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription	R-HSA-504046	6.16	3	POLR1C, POLR3A, POLR3B
RNA Polymerase III Transcription Initiation From Type 3 Promoter	R-HSA-76071	8.18	3	POLR1C, POLR3A, POLR3B
RNA Polymerase III Abortive And Retractive Initiation	R-HSA-749476	7.66	3	POLR1C, POLR3A, POLR3B
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.94	3	POLR1C, POLR3A, POLR3B
RNA Polymerase III Transcription Termination	R-HSA-73980	8.46	3	POLR1C, POLR3A, POLR3B
RNA Polymerase III Transcription Initiation From Type 2 Promoter	R-HSA-76066	8.28	3	POLR1C, POLR3A, POLR3B
RNA Polymerase III Transcription	R-HSA-74158	7.66	3	POLR1C, POLR3A, POLR3B
RNA Polymerase III Transcription Initiation From Type 1 Promoter	R-HSA-76061	8.23	3	POLR1C, POLR3A, POLR3B
Cytosolic tRNA aminoacylation	R-HSA-379716	8.4	2	AIMP1, RARS
tRNA Aminoacylation	R-HSA-379724	7.59	2	AIMP1, RARS
Gap junction trafficking	R-HSA-190828	7.59	2	TUBB4A, GJC2
Metabolism of proteins	R-HSA-392499	3.41	2	HSPD1, TUBB4A
Membrane Trafficking	R-HSA-199991	5.26	2	TUBB4A, GJC2
Gap junction trafficking and regulation	R-HSA-157858	7.52	2	TUBB4A, GJC2
Gap junction assembly	R-HSA-190861	8.03	2	TUBB4A, GJC2
Vesicle-mediated transport	R-HSA-5653656	4.33	2	TUBB4A, GJC2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Cytosolic tRNA aminoacylation (R-HSA-379716)	-	8.4	0.024	AIMP1, RARS
RNA Polymerase III Transcription Initiation (R-HSA-76046)	-	7.85	0.001	POLR1C, POLR3A, POLR3B
tRNA Aminoacylation (R-HSA-379724)	-	7.59	0.006	HSPD1, AIMP1, RARS
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription (R-HSA-504046)	-	6.16	0.017	HSPD1, POLR1C, POLR3A, POLR3B
RNA Polymerase III Transcription Initiation From Type 2 Promoter (R-HSA-76066)	-	8.28	0.0	POLR1C, POLR3A, POLR3B
Cytosolic sensors of pathogen-associated DNA (R-HSA-1834949)	-	6.94	0.003	POLR1C, POLR3A, POLR3B
RNA Polymerase III Abortive And Retractive Initiation (R-HSA-749476)	-	7.66	0.004	POLR1C, POLR3A, POLR3B
RNA Polymerase III Transcription Initiation From Type 3 Promoter (R-HSA-76071)	-	8.18	0.0	POLR1C, POLR3A, POLR3B
RNA Polymerase III Transcription Termination (R-HSA-73980)	-	8.46	0.001	POLR1C, POLR3A, POLR3B
Gap junction assembly (R-HSA-190861)	-	8.03	0.04	TUBB4A, GJC2
RNA Polymerase III Chain Elongation (R-HSA-73780)	-	8.81	0.0	POLR1C, POLR3A, POLR3B
RNA Polymerase III Transcription (R-HSA-74158)	-	7.66	0.004	POLR1C, POLR3A, POLR3B
RNA Polymerase III Transcription Initiation From Type 1 Promoter (R-HSA-76061)	-	8.23	0.001	POLR1C, POLR3A, POLR3B

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	10	POLR3A, RARS, POLR1C, VPS11, FAM126A, PLP1, POLR3B, HSPD1, TUBB4A, AIMP1
organic cyclic compound binding (GO:0097159)	1.05	8	POLR3A, RARS, POLR1C, VPS11, POLR3B, HSPD1, TUBB4A, AIMP1
heterocyclic compound binding (GO:1901363)	1.06	8	POLR3A, RARS, POLR1C, VPS11, POLR3B, HSPD1, TUBB4A, AIMP1
protein binding (GO:0005515)	0.46	8	RARS, POLR1C, VPS11, FAM126A, PLP1, HSPD1, TUBB4A, AIMP1
catalytic activity (GO:0003824)	1.05	7	POLR3B, RARS, POLR1C, PYCR2, POLR3A, HSPD1, TUBB4A
nucleic acid binding (GO:0003676)	1.44	6	POLR3B, RARS, POLR1C, POLR3A, HSPD1, AIMP1
small molecule binding (GO:0036094)	1.89	5	HSPD1, TUBB4A, POLR3B, RARS, VPS11
carbohydrate derivative binding (GO:0097367)	2.03	4	HSPD1, TUBB4A, RARS, POLR3B
ribonucleoside binding (GO:0032549)	2.22	4	HSPD1, TUBB4A, POLR3B, RARS
ion binding (GO:0043167)	1.36	4	POLR3A, POLR3B, RARS, VPS11
DNA binding (GO:0003677)	1.92	4	HSPD1, POLR1C, POLR3A, POLR3B
nucleotide binding (GO:0000166)	1.96	4	HSPD1, TUBB4A, VPS11, RARS
nucleoside phosphate binding (GO:1901265)	1.96	4	HSPD1, TUBB4A, VPS11, RARS
nucleoside binding (GO:0001882)	2.21	4	HSPD1, TUBB4A, POLR3B, RARS
cation binding (GO:0043169)	1.4	3	POLR3A, VPS11, POLR3B
nucleotidyltransferase activity (GO:0016779)	4.81	3	POLR1C, POLR3A, POLR3B
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	3	HSPD1, TUBB4A, RARS
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	3	POLR1C, POLR3A, POLR3B
RNA polymerase activity (GO:0034062)	5.93	3	POLR1C, POLR3A, POLR3B
transferase activity (GO:0016740)	1.95	3	POLR1C, POLR3A, POLR3B
RNA polymerase III activity (GO:0001056)	6.85	3	POLR1C, POLR3A, POLR3B
RNA binding (GO:0003723)	2.36	3	HSPD1, AIMP1, RARS
purine nucleoside binding (GO:0001883)	2.22	3	HSPD1, TUBB4A, RARS
DNA-directed RNA polymerase activity (GO:0003899)	5.98	3	POLR1C, POLR3A, POLR3B
purine ribonucleotide binding (GO:0032555)	2.2	3	HSPD1, TUBB4A, RARS
purine nucleotide binding (GO:0017076)	2.19	3	HSPD1, TUBB4A, RARS
metal ion binding (GO:0046872)	1.41	3	POLR3A, VPS11, POLR3B
purine ribonucleoside binding (GO:0032550)	2.22	3	HSPD1, TUBB4A, RARS
ribonucleotide binding (GO:0032553)	2.19	3	HSPD1, TUBB4A, RARS
hydrolase activity (GO:0016787)	1.9	2	HSPD1, TUBB4A
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	2	HSPD1, TUBB4A
tRNA binding (GO:0000049)	5.95	2	AIMP1, RARS
adenyl nucleotide binding (GO:0030554)	2.4	2	HSPD1, RARS
nucleoside-triphosphatase activity (GO:0017111)	3.09	2	HSPD1, TUBB4A
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	2	HSPD1, TUBB4A
enzyme binding (GO:0019899)	2.27	2	HSPD1, AIMP1
structural molecule activity (GO:0005198)	3.1	2	PLP1, TUBB4A
pyrophosphatase activity (GO:0016462)	3.04	2	HSPD1, TUBB4A
adenyl ribonucleotide binding (GO:0032559)	2.41	2	HSPD1, RARS
protein dimerization activity (GO:0046983)	2.72	2	POLR1C, AIMP1
ATP binding (GO:0005524)	2.43	2	HSPD1, RARS

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
nucleotidyltransferase activity (GO:0016779)	-	4.81	0.013	HSPD1, POLR1C, POLR3A, POLR3B
tRNA binding (GO:0000049)	-	5.95	0.028	HSPD1, AIMP1, RARS
RNA polymerase activity (GO:0034062)	-	5.93	0.0	HSPD1, POLR1C, POLR3A, POLR3B
aminoacyl-tRNA ligase activity (GO:0004812)	NEW	5.93	0.004	HSPD1, AIMP1, RARS
DNA-directed RNA polymerase activity (GO:0003899)	-	5.98	0.0	HSPD1, POLR1C, POLR3A, POLR3B
ligase activity, forming carbon-oxygen bonds (GO:0016875)	NEW	5.93	0.005	HSPD1, AIMP1, RARS
ligase activity, forming aminoacyl-tRNA and related compounds (GO:0016876)	NEW	5.93	0.005	HSPD1, AIMP1, RARS

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	12	RARS, GJC2, POLR1C, VPS11, FAM126A, PYCR2, PLP1, POLR3A, HSPD1, TUBB4A, AIMP1, POLR3B
primary metabolic process (GO:0044238)	0.69	9	POLR3A, RARS, POLR1C, FAM126A, HSPD1, PLP1, POLR3B, PYCR2, AIMP1
cellular metabolic process (GO:0044237)	0.69	9	POLR3B, RARS, POLR1C, FAM126A, PYCR2, PLP1, POLR3A, HSPD1, AIMP1
organic substance metabolic process (GO:0071704)	0.63	9	POLR3B, RARS, POLR1C, FAM126A, PYCR2, PLP1, POLR3A, HSPD1, AIMP1
single-organism cellular process (GO:0044763)	0.65	9	GJC2, RARS, VPS11, FAM126A, PYCR2, PLP1, HSPD1, TUBB4A, AIMP1
metabolic process (GO:0008152)	0.58	9	POLR3A, RARS, POLR1C, FAM126A, HSPD1, PLP1, POLR3B, PYCR2, AIMP1
single-organism process (GO:0044699)	0.48	9	GJC2, RARS, VPS11, FAM126A, PYCR2, PLP1, HSPD1, TUBB4A, AIMP1
biological regulation (GO:0065007)	0.39	8	POLR3B, POLR1C, VPS11, FAM126A, PLP1, POLR3A, HSPD1, AIMP1
regulation of biological process (GO:0050789)	0.45	8	POLR3B, POLR1C, VPS11, FAM126A, PLP1, POLR3A, HSPD1, AIMP1
organic substance biosynthetic process (GO:1901576)	1.34	7	POLR3B, RARS, POLR1C, PLP1, POLR3A, PYCR2, AIMP1
response to stimulus (GO:0050896)	1.22	7	POLR3B, GJC2, PYCR2, PLP1, POLR3A, HSPD1, AIMP1
nitrogen compound metabolic process (GO:0006807)	1.13	7	POLR3B, RARS, POLR1C, PYCR2, POLR3A, HSPD1, AIMP1
biosynthetic process (GO:0009058)	1.32	7	POLR3B, RARS, POLR1C, PLP1, POLR3A, PYCR2, AIMP1
cellular biosynthetic process (GO:0044249)	1.37	7	POLR3B, RARS, POLR1C, PLP1, POLR3A, PYCR2, AIMP1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	6	POLR3B, RARS, POLR1C, POLR3A, HSPD1, AIMP1
single-organism metabolic process (GO:0044710)	1.63	6	RARS, FAM126A, PYCR2, PLP1, HSPD1, AIMP1
cellular macromolecule metabolic process (GO:0044260)	0.93	6	POLR3B, RARS, POLR1C, POLR3A, HSPD1, AIMP1
cellular aromatic compound metabolic process (GO:0006725)	1.3	6	POLR3B, RARS, POLR1C, POLR3A, HSPD1, AIMP1
cellular nitrogen compound metabolic process (GO:0034641)	1.22	6	POLR3B, RARS, POLR1C, POLR3A, HSPD1, AIMP1
macromolecule metabolic process (GO:0043170)	0.83	6	POLR3B, RARS, POLR1C, POLR3A, HSPD1, AIMP1
nucleic acid metabolic process (GO:0090304)	1.46	6	POLR3B, RARS, POLR1C, POLR3A, HSPD1, AIMP1
response to stress (GO:0006950)	1.8	6	POLR3B, PYCR2, PLP1, POLR3A, HSPD1, AIMP1
positive regulation of biological process (GO:0048518)	1.2	6	POLR3B, POLR1C, VPS11, PLP1, POLR3A, HSPD1
regulation of cellular process (GO:0050794)	0.5	6	VPS11, FAM126A, PLP1, POLR3A, HSPD1, AIMP1
organic cyclic compound metabolic process (GO:1901360)	1.26	6	POLR3B, RARS, POLR1C, POLR3A, HSPD1, AIMP1
heterocycle metabolic process (GO:0046483)	1.31	6	POLR3B, RARS, POLR1C, POLR3A, HSPD1, AIMP1
RNA metabolic process (GO:0016070)	1.59	5	POLR3A, POLR1C, AIMP1, POLR3B, RARS
macromolecule biosynthetic process (GO:0009059)	1.61	5	POLR3A, POLR1C, AIMP1, POLR3B, RARS
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	5	POLR1C, AIMP1, RARS, POLR3A, POLR3B
cellular macromolecule biosynthetic process (GO:0034645)	1.66	5	POLR3A, POLR1C, AIMP1, POLR3B, RARS
positive regulation of metabolic process (GO:0009893)	1.74	4	HSPD1, POLR1C, PLP1, VPS11
regulation of metabolic process (GO:0019222)	1.02	4	HSPD1, PLP1, POLR1C, VPS11
carboxylic acid metabolic process (GO:0019752)	3.12	4	PYCR2, PLP1, AIMP1, RARS
signal transduction (GO:0007165)	1.28	4	HSPD1, FAM126A, PLP1, AIMP1
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	4	HSPD1, PLP1, POLR1C, VPS11
positive regulation of multicellular organismal process (GO:0051240)	2.49	4	HSPD1, POLR1C, POLR3A, POLR3B
interspecies interaction between organisms (GO:0044419)	3.08	4	HSPD1, AIMP1, POLR3B, POLR3A
small molecule metabolic process (GO:0044281)	2.38	4	PYCR2, PLP1, AIMP1, RARS
regulation of macromolecule metabolic process (GO:0060255)	1.08	4	HSPD1, PLP1, POLR1C, VPS11
immune effector process (GO:0002252)	3.58	4	HSPD1, AIMP1, POLR3A, POLR3B
defense response (GO:0006952)	2.78	4	PLP1, AIMP1, POLR3B, POLR3A
positive regulation of type I interferon production (GO:0032481)	5.48	4	HSPD1, POLR1C, POLR3A, POLR3B
multi-organism cellular process (GO:0044764)	3.14	4	HSPD1, AIMP1, POLR3B, POLR3A
regulation of multicellular organismal process (GO:0051239)	1.87	4	HSPD1, POLR1C, POLR3A, POLR3B
oxoacid metabolic process (GO:0043436)	3.12	4	PYCR2, PLP1, AIMP1, RARS
multi-organism process (GO:0051704)	2.65	4	HSPD1, AIMP1, POLR3A, POLR3B
organic acid metabolic process (GO:0006082)	3.01	4	PYCR2, PLP1, AIMP1, RARS
immune system process (GO:0002376)	2.29	4	HSPD1, AIMP1, POLR3B, POLR3A
regulation of cytokine production (GO:0001817)	3.4	4	HSPD1, POLR1C, POLR3A, POLR3B
viral process (GO:0016032)	3.15	4	HSPD1, AIMP1, POLR3A, POLR3B
regulation of type I interferon production (GO:0032479)	5.03	4	HSPD1, POLR1C, POLR3A, POLR3B
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	4	HSPD1, AIMP1, POLR3A, POLR3B
positive regulation of cytokine production (GO:0001819)	3.82	4	HSPD1, POLR1C, POLR3A, POLR3B
RNA biosynthetic process (GO:0032774)	1.84	3	POLR1C, POLR3A, POLR3B
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	3	POLR1C, POLR3A, POLR3B
signaling (GO:0023052)	3.25	3	PLP1, AIMP1, GJC2
response to chemical (GO:0042221)	1.98	3	HSPD1, PYCR2, GJC2
organic cyclic compound biosynthetic process (GO:1901362)	1.66	3	POLR1C, POLR3A, POLR3B
organonitrogen compound biosynthetic process (GO:1901566)	2.85	3	PYCR2, AIMP1, RARS
nucleic acid-templated transcription (GO:0097659)	1.91	3	POLR1C, POLR3A, POLR3B
response to external biotic stimulus (GO:0043207)	3.13	3	AIMP1, POLR3A, POLR3B
response to virus (GO:0009615)	4.21	3	AIMP1, POLR3B, POLR3A
cellular amino acid metabolic process (GO:0006520)	4.22	3	PYCR2, AIMP1, RARS
cellular component organization (GO:0016043)	1.24	3	HSPD1, PLP1, VPS11
cellular component organization or biogenesis (GO:0071840)	1.22	3	HSPD1, PLP1, VPS11
transcription from RNA polymerase III promoter (GO:0006383)	6.12	3	POLR1C, POLR3A, POLR3B
heterocycle biosynthetic process (GO:0018130)	1.7	3	POLR1C, POLR3A, POLR3B
defense response to other organism (GO:0098542)	3.75	3	AIMP1, POLR3B, POLR3A
immune response (GO:0006955)	2.86	3	HSPD1, POLR3A, POLR3B
cell-cell signaling (GO:0007267)	3.35	3	PLP1, AIMP1, GJC2
organonitrogen compound metabolic process (GO:1901564)	2.32	3	PYCR2, AIMP1, RARS
establishment of localization (GO:0051234)	1.48	3	FAM126A, VPS11, GJC2
response to other organism (GO:0051707)	3.48	3	AIMP1, POLR3A, POLR3B
localization (GO:0051179)	1.4	3	FAM126A, VPS11, GJC2
single organism signaling (GO:0044700)	3.25	3	PLP1, AIMP1, GJC2
response to biotic stimulus (GO:0009607)	3.09	3	AIMP1, POLR3B, POLR3A
defense response to virus (GO:0051607)	4.63	3	AIMP1, POLR3A, POLR3B
response to external stimulus (GO:0009605)	2.55	3	AIMP1, POLR3B, POLR3A
protein metabolic process (GO:0019538)	1.45	3	HSPD1, AIMP1, RARS
cell communication (GO:0007154)	3.04	3	PLP1, AIMP1, GJC2
transcription, DNA-templated (GO:0006351)	1.91	3	POLR1C, POLR3A, POLR3B
aromatic compound biosynthetic process (GO:0019438)	1.7	3	POLR1C, POLR3A, POLR3B
positive regulation of cellular process (GO:0048522)	1.3	3	HSPD1, POLR3A, VPS11
regulation of intracellular protein transport (GO:0033157)	3.8	2	POLR3A, VPS11
positive regulation of intracellular transport (GO:0032388)	4.08	2	POLR3A, VPS11
regulation of primary metabolic process (GO:0080090)	1.08	2	HSPD1, VPS11
regulation of cellular localization (GO:0060341)	3.03	2	POLR3A, VPS11
regulation of organelle organization (GO:0033043)	2.72	2	POLR3A, VPS11
regulation of transport (GO:0051049)	2.24	2	POLR3A, VPS11
regulation of intracellular transport (GO:0032386)	3.58	2	POLR3A, VPS11
small molecule biosynthetic process (GO:0044283)	3.79	2	PYCR2, PLP1
regulation of response to stimulus (GO:0048583)	1.54	2	HSPD1, POLR3B
regulation of interferon-beta production (GO:0032648)	5.92	2	POLR3A, POLR3B
regulation of cellular component organization (GO:0051128)	2.01	2	POLR3A, VPS11
regulation of cellular protein localization (GO:1903827)	3.43	2	POLR3A, VPS11
peptide biosynthetic process (GO:0043043)	3.73	2	AIMP1, RARS
regulation of mitochondrion organization (GO:0010821)	4.34	2	POLR3A, VPS11
regulation of protein targeting (GO:1903533)	4.0	2	POLR3A, VPS11
positive regulation of mitochondrion organization (GO:0010822)	4.61	2	POLR3A, VPS11
ncRNA metabolic process (GO:0034660)	3.44	2	AIMP1, RARS
ensheathment of neurons (GO:0007272)	5.48	2	FAM126A, PLP1
regulation of protein transport (GO:0051223)	3.12	2	POLR3A, VPS11
positive regulation of protein transport (GO:0051222)	3.61	2	POLR3A, VPS11
positive regulation of cellular protein localization (GO:1903829)	3.85	2	POLR3A, VPS11
regulation of innate immune response (GO:0045088)	3.86	2	HSPD1, POLR3B
cellular protein metabolic process (GO:0044267)	1.63	2	AIMP1, RARS
single-organism biosynthetic process (GO:0044711)	2.8	2	PYCR2, PLP1
myelination (GO:0042552)	5.52	2	FAM126A, PLP1
positive regulation of gene expression (GO:0010628)	2.35	2	PLP1, POLR1C
regulation of protein metabolic process (GO:0051246)	1.93	2	HSPD1, VPS11
positive regulation of protein metabolic process (GO:0051247)	2.43	2	HSPD1, VPS11
positive regulation of immune system process (GO:0002684)	2.96	2	HSPD1, POLR3B
amide biosynthetic process (GO:0043604)	3.6	2	AIMP1, RARS
regulation of immune system process (GO:0002682)	2.5	2	HSPD1, POLR3B
regulation of defense response (GO:0031347)	3.11	2	HSPD1, POLR3B
positive regulation of interferon-beta production (GO:0032728)	6.29	2	POLR3A, POLR3B
negative regulation of biological process (GO:0048519)	1.33	2	HSPD1, AIMP1
regulation of protein localization (GO:0032880)	2.88	2	POLR3A, VPS11
positive regulation of establishment of protein localization (GO:1904951)	3.49	2	POLR3A, VPS11
developmental process (GO:0032502)	1.36	2	PLP1, AIMP1
regulation of establishment of protein localization (GO:0070201)	3.02	2	POLR3A, VPS11
positive regulation of response to stimulus (GO:0048584)	2.18	2	HSPD1, POLR3B
positive regulation of innate immune response (GO:0045089)	4.22	2	HSPD1, POLR3B
lipid metabolic process (GO:0006629)	2.68	2	FAM126A, PLP1
positive regulation of transport (GO:0051050)	2.9	2	POLR3A, VPS11
establishment of protein localization (GO:0045184)	2.53	2	FAM126A, VPS11
regulation of cellular metabolic process (GO:0031323)	1.07	2	HSPD1, VPS11
innate immune response (GO:0045087)	3.55	2	POLR3A, POLR3B
transport (GO:0006810)	1.51	2	VPS11, GJC2
positive regulation of intracellular protein transport (GO:0090316)	4.19	2	POLR3A, VPS11
single-organism developmental process (GO:0044767)	1.49	2	PLP1, AIMP1
regulation of establishment of protein localization to mitochondrion (GO:1903747)	4.88	2	POLR3A, VPS11
positive regulation of protein targeting to mitochondrion (GO:1903955)	5.26	2	POLR3A, VPS11
regulation of cellular protein metabolic process (GO:0032268)	1.99	2	HSPD1, VPS11
axon ensheathment (GO:0008366)	5.48	2	FAM126A, PLP1
inflammatory response (GO:0006954)	3.64	2	PLP1, AIMP1
cell adhesion (GO:0007155)	2.82	2	HSPD1, AIMP1
cellular lipid metabolic process (GO:0044255)	2.92	2	FAM126A, PLP1
regulation of localization (GO:0032879)	1.94	2	POLR3A, VPS11
positive regulation of immune response (GO:0050778)	3.4	2	HSPD1, POLR3B
positive regulation of establishment of protein localization to mitochondrion (GO:1903749)	4.98	2	POLR3A, VPS11
positive regulation of defense response (GO:0031349)	3.83	2	HSPD1, POLR3B
regulation of immune response (GO:0050776)	2.98	2	HSPD1, POLR3B
regulation of biological quality (GO:0065008)	1.68	2	HSPD1, VPS11
cellular amide metabolic process (GO:0043603)	3.23	2	AIMP1, RARS
carboxylic acid biosynthetic process (GO:0046394)	4.32	2	PYCR2, PLP1
biological adhesion (GO:0022610)	2.81	2	HSPD1, AIMP1
regulation of response to stress (GO:0080134)	2.53	2	HSPD1, POLR3B
regulation of protein stability (GO:0031647)	4.33	2	HSPD1, VPS11
positive regulation of organelle organization (GO:0010638)	3.38	2	POLR3A, VPS11
organic acid biosynthetic process (GO:0016053)	4.26	2	PYCR2, PLP1
positive regulation of cellular metabolic process (GO:0031325)	1.81	2	HSPD1, VPS11
regulation of gene expression (GO:0010468)	1.37	2	PLP1, POLR1C
tRNA metabolic process (GO:0006399)	4.52	2	AIMP1, RARS
amino acid activation (GO:0043038)	5.76	2	AIMP1, RARS
tRNA aminoacylation (GO:0043039)	5.76	2	AIMP1, RARS
regulation of protein targeting to mitochondrion (GO:1903214)	5.14	2	POLR3A, VPS11
tRNA aminoacylation for protein translation (GO:0006418)	5.82	2	AIMP1, RARS
peptide metabolic process (GO:0006518)	3.44	2	AIMP1, RARS
positive regulation of cellular component organization (GO:0051130)	2.68	2	POLR3A, VPS11
translation (GO:0006412)	3.79	2	AIMP1, RARS
negative regulation of cellular process (GO:0048523)	1.41	2	HSPD1, AIMP1
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	HSPD1, VPS11

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
DNA-templated transcription, termination (GO:0006353)	NEW	5.12	0.011	POLR1C, POLR3A, POLR3B
positive regulation of type I interferon production (GO:0032481)	-	5.48	0.002	HSPD1, POLR1C, POLR3A, POLR3B
tRNA aminoacylation for protein translation (GO:0006418)	-	5.82	0.015	HSPD1, AIMP1, RARS
gene expression (GO:0010467)	NEW	5.8	0.026	POLR1C, AIMP1, POLR3A, RARS, POLR3B
DNA-templated transcription, elongation (GO:0006354)	NEW	5.15	0.014	POLR1C, POLR3A, POLR3B
amino acid activation (GO:0043038)	-	5.76	0.02	HSPD1, AIMP1, RARS
tRNA aminoacylation (GO:0043039)	-	5.76	0.02	HSPD1, AIMP1, RARS
positive regulation of interferon-beta production (GO:0032728)	-	6.29	0.044	POLR3A, POLR3B
regulation of type I interferon production (GO:0032479)	-	5.03	0.0	HSPD1, POLR1C, POLR3A, POLR3B
termination of RNA polymerase III transcription (GO:0006386)	NEW	9.73	0.0	POLR1C, POLR3A, POLR3B
cytoplasmic transport (GO:0016482)	NEW	4.98	0.024	RARS, C11orf73, VPS11, POLR3B, HSPD1, TUBB4A, AIMP1
transcription from RNA polymerase III promoter (GO:0006383)	-	6.12	0.007	POLR1C, POLR3A, POLR3B
positive regulation of cytokine production (GO:0001819)	-	3.82	0.012	HSPD1, POLR1C, POLR3A, POLR3B

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	12	POLR3A, GJC2, RARS, POLR1C, VPS11, FAM126A, PYCR2, PLP1, POLR3B, HSPD1, TUBB4A, AIMP1
intracellular part (GO:0044424)	0.28	10	POLR3A, RARS, POLR1C, VPS11, FAM126A, PYCR2, POLR3B, HSPD1, TUBB4A, AIMP1
cytoplasmic part (GO:0044444)	0.82	10	POLR3A, RARS, POLR1C, VPS11, FAM126A, PYCR2, POLR3B, HSPD1, TUBB4A, AIMP1
intracellular organelle (GO:0043229)	0.51	9	POLR3A, RARS, POLR1C, VPS11, PYCR2, POLR3B, HSPD1, TUBB4A, AIMP1
membrane-bounded organelle (GO:0043227)	0.47	9	POLR3A, RARS, POLR1C, VPS11, PYCR2, POLR3B, HSPD1, TUBB4A, AIMP1
intracellular membrane-bounded organelle (GO:0043231)	0.6	9	POLR3A, RARS, POLR1C, VPS11, PYCR2, POLR3B, HSPD1, TUBB4A, AIMP1
organelle (GO:0043226)	0.4	9	POLR3A, RARS, POLR1C, VPS11, PYCR2, POLR3B, HSPD1, TUBB4A, AIMP1
protein complex (GO:0043234)	1.51	8	POLR3A, GJC2, RARS, POLR1C, VPS11, POLR3B, HSPD1, AIMP1
macromolecular complex (GO:0032991)	1.35	8	POLR3A, GJC2, RARS, POLR1C, VPS11, POLR3B, HSPD1, AIMP1
cytosol (GO:0005829)	1.68	8	POLR3A, RARS, POLR1C, FAM126A, POLR3B, HSPD1, TUBB4A, AIMP1
membrane (GO:0016020)	0.68	8	GJC2, RARS, VPS11, FAM126A, PLP1, POLR3A, HSPD1, AIMP1
intracellular organelle part (GO:0044446)	0.81	8	POLR3A, RARS, POLR1C, VPS11, PYCR2, POLR3B, HSPD1, TUBB4A
organelle part (GO:0044422)	0.79	8	POLR3A, RARS, POLR1C, VPS11, PYCR2, POLR3B, HSPD1, TUBB4A
cytoplasm (GO:0005737)	1.01	6	RARS, FAM126A, PYCR2, HSPD1, TUBB4A, AIMP1
nucleus (GO:0005634)	1.07	5	TUBB4A, AIMP1, POLR1C, POLR3A, POLR3B
nuclear part (GO:0044428)	1.55	5	HSPD1, POLR3A, POLR1C, POLR3B, RARS
vesicle (GO:0031982)	1.64	5	HSPD1, TUBB4A, AIMP1, VPS11, RARS
membrane-bounded vesicle (GO:0031988)	1.71	5	HSPD1, TUBB4A, AIMP1, VPS11, RARS
catalytic complex (GO:1902494)	2.9	4	HSPD1, POLR1C, POLR3A, POLR3B
transferase complex, transferring phosphorus-containing groups (GO:0061695)	4.61	4	HSPD1, POLR1C, POLR3A, POLR3B
nucleoplasm (GO:0005654)	1.89	4	POLR3A, POLR1C, POLR3B, RARS
transferase complex (GO:1990234)	3.32	4	HSPD1, POLR1C, POLR3A, POLR3B
membrane part (GO:0044425)	0.95	4	HSPD1, PLP1, VPS11, GJC2
extracellular region part (GO:0044421)	1.57	4	HSPD1, TUBB4A, AIMP1, RARS
membrane protein complex (GO:0098796)	2.84	3	HSPD1, VPS11, GJC2
extracellular organelle (GO:0043230)	1.89	3	HSPD1, TUBB4A, RARS
RNA polymerase complex (GO:0030880)	5.83	3	POLR1C, POLR3A, POLR3B
nuclear DNA-directed RNA polymerase complex (GO:0055029)	5.87	3	POLR1C, POLR3A, POLR3B
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	3	HSPD1, AIMP1, VPS11
cytoplasmic vesicle (GO:0031410)	2.87	3	HSPD1, AIMP1, VPS11
plasma membrane (GO:0005886)	1.39	3	FAM126A, PLP1, GJC2
DNA-directed RNA polymerase complex (GO:0000428)	5.87	3	POLR1C, POLR3A, POLR3B
mitochondrion (GO:0005739)	2.42	3	HSPD1, PYCR2, RARS
myelin sheath (GO:0043209)	4.76	3	PLP1, TUBB4A, GJC2
nucleoplasm part (GO:0044451)	3.22	3	POLR1C, POLR3A, POLR3B
intracellular vesicle (GO:0097708)	2.86	3	HSPD1, AIMP1, VPS11
DNA-directed RNA polymerase III complex (GO:0005666)	6.91	3	POLR1C, POLR3A, POLR3B
extracellular vesicle (GO:1903561)	1.89	3	HSPD1, TUBB4A, RARS
extracellular exosome (GO:0070062)	1.89	3	HSPD1, TUBB4A, RARS
endosome (GO:0005768)	3.25	2	HSPD1, VPS11
aminoacyl-tRNA synthetase multienzyme complex (GO:0017101)	8.42	2	AIMP1, RARS
supramolecular fiber (GO:0099512)	3.31	2	TUBB4A, VPS11
polymeric cytoskeletal fiber (GO:0099513)	3.31	2	TUBB4A, VPS11
organelle lumen (GO:0043233)	3.05	2	PYCR2, HSPD1
vacuole (GO:0005773)	2.92	2	HSPD1, VPS11
extracellular space (GO:0005615)	2.63	2	HSPD1, AIMP1
integral component of membrane (GO:0016021)	1.14	2	PLP1, GJC2
membrane-enclosed lumen (GO:0031974)	3.05	2	HSPD1, PYCR2
early endosome (GO:0005769)	4.34	2	HSPD1, VPS11
intracellular organelle lumen (GO:0070013)	3.05	2	HSPD1, PYCR2
cytoskeletal part (GO:0044430)	2.49	2	TUBB4A, VPS11
mitochondrial part (GO:0044429)	2.92	2	PYCR2, HSPD1
mitochondrial matrix (GO:0005759)	4.03	2	HSPD1, PYCR2
coated vesicle (GO:0030135)	4.94	2	HSPD1, VPS11
cell surface (GO:0009986)	3.44	2	HSPD1, AIMP1
intrinsic component of membrane (GO:0031224)	1.13	2	PLP1, GJC2
organelle membrane (GO:0031090)	1.97	2	HSPD1, VPS11

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein complex (GO:0043234)	-	1.51	0.022	POLR3A, GJC2, RARS, POLR1C, VPS11, POLR3B, HSPD1, TUBB4A, AIMP1
aminoacyl-tRNA synthetase multienzyme complex (GO:0017101)	-	8.42	0.0	AIMP1, RARS
RNA polymerase complex (GO:0030880)	-	5.83	0.0	POLR1C, POLR3A, POLR3B
nuclear DNA-directed RNA polymerase complex (GO:0055029)	-	5.87	0.0	POLR1C, POLR3A, POLR3B
myelin sheath (GO:0043209)	-	4.76	0.001	PLP, TUBB4A, GJC2
cytosol (GO:0005829)	-	1.68	0.007	POLR3A, RARS, POLR1C, POLR3B, HSPD1, TUBB4A, AIMP1, C11orf73
DNA-directed RNA polymerase complex (GO:0000428)	-	5.87	0.0	POLR1C, POLR3A, POLR3B
cis-Golgi network (GO:0005801)	NEW	6.16	0.004	POLR1C, AIMP1, POLR3B
DNA-directed RNA polymerase III complex (GO:0005666)	-	6.91	0.0	POLR1C, POLR3A, POLR3B
endosome (GO:0005768)	-	3.25	0.025	POLR3B, RARS, VPS11, POLR3A, HSPD1, TUBB4A