Disease ID | Disease name | Source of annotation with GCGR | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
125853 | DIABETES MELLITUS, NONINSULIN-DEPENDENT | ClinVar, OMIM | link to OMIM | 33 | SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11 |
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KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Neuroactive ligand-receptor interaction | hsa04080 | 4.58 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Class B/2 (Secretin family receptors) | R-HSA-373080 | 6.52 |
Glucagon-type ligand receptors | R-HSA-420092 | 8.08 |
Signaling by GPCR | R-HSA-372790 | 2.68 |
GPCR downstream signaling | R-HSA-388396 | 3.07 |
Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 |
Integration of energy metabolism | R-HSA-163685 | 6.24 |
G alpha (q) signalling events | R-HSA-416476 | 5.42 |
Metabolism | R-HSA-1430728 | 2.34 |
GPCR ligand binding | R-HSA-500792 | 4.19 |
G alpha (s) signalling events | R-HSA-418555 | 5.99 |
Signal Transduction | R-HSA-162582 | 1.78 |
Glucagon signaling in metabolic regulation | R-HSA-163359 | 7.94 |
GO term | GO ID | GO IC |
---|---|---|
peptide hormone binding | GO:0017046 | 6.13 |
G-protein coupled peptide receptor activity | GO:0008528 | 4.86 |
G-protein coupled receptor activity | GO:0004930 | 2.95 |
signaling receptor activity | GO:0038023 | 2.49 |
amide binding | GO:0033218 | 4.14 |
guanyl-nucleotide exchange factor activity | GO:0005085 | 4.02 |
molecular transducer activity | GO:0060089 | 2.32 |
transmembrane signaling receptor activity | GO:0004888 | 2.57 |
peptide receptor activity | GO:0001653 | 4.84 |
receptor activity | GO:0004872 | 2.32 |
signal transducer activity | GO:0004871 | 2.28 |
peptide binding | GO:0042277 | 4.22 |
glucagon receptor activity | GO:0004967 | 8.64 |
molecular function regulator | GO:0098772 | 2.51 |
hormone binding | GO:0042562 | 5.53 |
transmembrane receptor activity | GO:0099600 | 2.53 |
binding | GO:0005488 | 0.18 |