Gene table of IRS2 : insulin receptor substrate 2

Gene-disease associations table

Disease IDDisease nameSource of annotation with IRS2OMIM linkNumber of associated genesgenes
125853DIABETES MELLITUS, NONINSULIN-DEPENDENTOMIM link to OMIM 33SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11

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Annotation of the gene IRS2

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
cGMP-PKG signaling pathwayhsa040225.32
AMPK signaling pathwayhsa041525.8
MicroRNAs in cancerhsa052065.38
Insulin signaling pathwayhsa049105.55
FoxO signaling pathwayhsa040685.63
Type II diabetes mellitushsa049307.12
Non-alcoholic fatty liver disease (NAFLD)hsa049325.51
Adipocytokine signaling pathwayhsa049206.6
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
NCAM signaling for neurite out-growthR-HSA-3751654.9
PI3K/AKT activationR-HSA-1982036.32
Signaling by InterleukinsR-HSA-4491474.71
PI3K events in ERBB4 signalingR-HSA-12503426.37
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
PI3K CascadeR-HSA-1097046.68
Signaling by LeptinR-HSA-25865525.1
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.05
PI3K events in ERBB2 signalingR-HSA-19636426.37
Cytokine Signaling in Immune systemR-HSA-12802153.74
IGF1R signaling cascadeR-HSA-24289244.85
Downstream signal transductionR-HSA-1867634.65
GAB1 signalosomeR-HSA-1802926.31
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by ERBB4R-HSA-12363944.7
IRS-mediated signallingR-HSA-1123994.87
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
DiseaseR-HSA-16436853.33
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
IRS activationR-HSA-7471310.66
Downstream signaling of activated FGFR1R-HSA-56546874.71
MAPK family signaling cascadesR-HSA-56830574.89
PIP3 activates AKT signalingR-HSA-12576046.37
PI-3K cascade:FGFR3R-HSA-56547106.37
Signaling by VEGFR-HSA-1941384.66
Signalling to p38 via RIT and RINR-HSA-1877065.12
PI-3K cascade:FGFR1R-HSA-56546896.37
FCERI mediated MAPK activationR-HSA-28717964.32
Signaling by EGFRR-HSA-1779294.59
FRS-mediated FGFR2 signalingR-HSA-56547005.14
SOS-mediated signallingR-HSA-1124125.15
FRS-mediated FGFR3 signalingR-HSA-56547065.14
Developmental BiologyR-HSA-12667383.48
Signaling by Insulin receptorR-HSA-747524.73
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
Downstream signaling of activated FGFR3R-HSA-56547084.71
RAF/MAP kinase cascadeR-HSA-56730015.15
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Interleukin receptor SHC signalingR-HSA-9125265.09
Signaling by FGFRR-HSA-1902364.67
PI3K/AKT Signaling in CancerR-HSA-22195286.56
Diseases of signal transductionR-HSA-56632024.89
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Immune SystemR-HSA-1682562.37
Downstream signaling of activated FGFR4R-HSA-56547164.71
Innate Immune SystemR-HSA-1682493.17
Signaling by SCF-KITR-HSA-14335574.73
Interleukin-2 signalingR-HSA-4519275.05
SHC1 events in ERBB2 signalingR-HSA-12501965.15
Signal attenuationR-HSA-747499.66
Signaling by ERBB2R-HSA-12279864.66
Signalling to RASR-HSA-1670445.08
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
PI-3K cascade:FGFR2R-HSA-56546956.37
Downstream signaling of activated FGFR2R-HSA-56546964.71
Signaling by FGFR1R-HSA-56547364.69
SHC1 events in EGFR signalingR-HSA-1803365.15
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
FRS-mediated FGFR1 signalingR-HSA-56546935.14
Prolonged ERK activation eventsR-HSA-1698935.11
FRS-mediated FGFR4 signalingR-HSA-56547125.14
Signalling by NGFR-HSA-1665204.23
Signaling by GPCRR-HSA-3727902.68
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signalling to ERKsR-HSA-1876875.04
Growth hormone receptor signalingR-HSA-9827728.4
Insulin receptor signalling cascadeR-HSA-747514.85
ARMS-mediated activationR-HSA-1709845.12
Frs2-mediated activationR-HSA-1709685.12
PI-3K cascade:FGFR4R-HSA-56547206.37
DAP12 interactionsR-HSA-21721274.56
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Axon guidanceR-HSA-4224753.93
VEGFR2 mediated cell proliferationR-HSA-52189215.07
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
Ras guanyl-nucleotide exchange factor activityGO:00050884.31
phosphatidylinositol 3-kinase activityGO:00350045.49
guanyl-nucleotide exchange factor activityGO:00050854.02
enzyme bindingGO:00198992.27
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
signal transducer activityGO:00048712.28
molecular function regulatorGO:00987722.51
phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469345.61
phosphatidylinositol 3-kinase bindingGO:00435486.41
phosphatidylinositol bisphosphate kinase activityGO:00528135.56
transferase activityGO:00167401.95
14-3-3 protein bindingGO:00718896.65
protein complex bindingGO:00324033.09
kinase activityGO:00163012.93
1-phosphatidylinositol-3-kinase activityGO:00163035.98
insulin receptor bindingGO:00051586.27
protein kinase bindingGO:00199013.44
kinase bindingGO:00199003.32
protein phosphatase bindingGO:00199034.93
phosphatase bindingGO:00199024.63
protein domain specific bindingGO:00199043.32
catalytic activityGO:00038241.05
phosphatidylinositol kinase activityGO:00527425.81
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
protein bindingGO:00055150.46
receptor bindingGO:00051022.43