| Disease ID | Disease name | Source of annotation with SLC30A8 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 125853 | DIABETES MELLITUS, NONINSULIN-DEPENDENT | ClinVar, OMIM | link to OMIM | 33 | SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11 |
Download the gene annotation in CSV format
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Insulin processing | R-HSA-264876 | 8.28 |
| Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds | R-HSA-425366 | 6.34 |
| Zinc efflux and compartmentalization by the SLC30 family | R-HSA-435368 | 10.18 |
| Metabolism of proteins | R-HSA-392499 | 3.41 |
| Peptide hormone metabolism | R-HSA-2980736 | 6.61 |
| Transmembrane transport of small molecules | R-HSA-382551 | 3.79 |
| SLC-mediated transmembrane transport | R-HSA-425407 | 4.95 |
| Zinc transporters | R-HSA-435354 | 8.89 |
| Metal ion SLC transporters | R-HSA-425410 | 8.34 |
| GO term | GO ID | GO IC |
|---|---|---|
| substrate-specific transmembrane transporter activity | GO:0022891 | 2.9 |
| divalent inorganic cation transmembrane transporter activity | GO:0072509 | 4.62 |
| metal ion binding | GO:0046872 | 1.41 |
| transition metal ion binding | GO:0046914 | 2.48 |
| transition metal ion transmembrane transporter activity | GO:0046915 | 6.05 |
| transporter activity | GO:0005215 | 2.57 |
| cation transmembrane transporter activity | GO:0008324 | 3.32 |
| cation binding | GO:0043169 | 1.4 |
| ion binding | GO:0043167 | 1.36 |
| ion transmembrane transporter activity | GO:0015075 | 3.04 |
| transmembrane transporter activity | GO:0022857 | 2.82 |
| substrate-specific transporter activity | GO:0022892 | 2.72 |
| zinc ion binding | GO:0008270 | 2.66 |
| protein binding | GO:0005515 | 0.46 |
| zinc ion transmembrane transporter activity | GO:0005385 | 6.56 |
| inorganic cation transmembrane transporter activity | GO:0022890 | 3.49 |
| metal ion transmembrane transporter activity | GO:0046873 | 3.71 |
| protein homodimerization activity | GO:0042803 | 3.16 |
| protein dimerization activity | GO:0046983 | 2.72 |
| identical protein binding | GO:0042802 | 2.63 |
| binding | GO:0005488 | 0.18 |