Disease table of 46,XY SEX REVERSAL OMIM ID: PS400044

Gene-disease associations table

GeneAssociated with 46,XY SEX REVERSAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
DHHOMIM, HUMSAVARHGNC link12q13.122607080, PS400044
ZFPM2ClinVar, OMIM, HUMSAVARHGNC link8q22.34187500, 610187, PS400044, 217095
NR0B1ClinVar, OMIMHGNC linkXp21.22PS400044, 300200
MAP3K1ClinVar, OMIM, HUMSAVARHGNC link5q11.21PS400044
NR5A1ClinVar, OMIM, HUMSAVARHGNC link9q33.33PS258150, 612964, PS400044
AKR1C4ClinVar, OMIMHGNC link10p15.11PS400044
SRYClinVar, OMIM, HUMSAVARHGNC linkYp11.22400045, PS400044
CBX2ClinVar, OMIM, HUMSAVARHGNC link17q25.31PS400044
AKR1C2ClinVar, OMIM, HUMSAVARHGNC link10p15.11PS400044

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 4552AKR1C2, AKR1C4
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
10p15.12AKR1C2, AKR1C4
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
10p152AKR1C2, AKR1C4
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
10p12AKR1C2, AKR1C4
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
10p2AKR1C2, AKR1C4
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
102AKR1C2, AKR1C4
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
NR0B1YES11NR5A1, CYP19A1, NR1H4, STAR, CYP17A1, PBX1, CAMP, ESRRG, HNF4A, AMH, NOS11NR5A1
NR5A1YES22HSD3B1, PNRC1, CYP2B6, NR0B1, POU5F1, CYP19A1, CYP11B1, STAR, PBX1, HSD3B2, FSHR, INSL3, LHB, NOV, AMH, SRY, STARD7, MC2R, CYP17A1, CYP11A1, CYP11B2, CITED22SRY, NR0B1
SRYYES5PROM1, NFKBIB, SOX9, WDR5, ETV20
WT1NO51MYC, NR5A1, CTGF, AR, CD97, TBXA2R, MYB, EGFR, HBEGF, DNMT3A, ITGAX, CCNE1, ABCB1, EREG, THBS1, CIAO1, NOV, NDRG2, SMAD3, CD14, SNAI2, NPHS1, CDKN1A, PDGFA, TERT, IRF8, VDR, PODXL, CDH1, STIM1, JUN, CKM, AMH, CYP19A1, VEGFA, VEGFB, ODC1, ETS1, KLK3, JUNB, BCL2, IGF1R, PAX2, IGF2, IL2RB, MYCN, IGF1, SRY, UBE2I, CX3CL1, CAMP2SRY, NR5A1
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12SRY, NR5A1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
NR0B1YES6SF1, STAT3, NR5A1, ESRRG, EWSR1, POU5F11NR5A1
MAP3K1YES2JUN, ATF20
NR5A1YES5SP1, WT1, SOX9, NR0B1, USF21NR0B1
AKR1C4YES3HNF4G, HNF1A, HNF4A0
SRYYES4SP1, WT1, TFCP2, NR5A11NR5A1
AKR1C2YES2TWIST2, TWIST10
STARNO14SP1, SF1, NR5A1, NR5A2, CREM, CEBPA, FOXL2, CLOCK, CEBPB, JUN, NR4A1, NR0B1, GATA4, FOS2NR5A1, NR0B1
CYP17A1NO12SP1, NR5A1, PIAS1, GATA4, GATA6, NFIC, NR2F1, NR4A1, CREB1, NR0B1, SP3, SMAD32NR5A1, NR0B1
AMHNO10WT1, SF1, NR5A1, ESR1, SOX9, VDR, RELA, NR0B1, GATA4, NFKB12NR5A1, NR0B1
PBX1NO2NR5A1, NR0B12NR5A1, NR0B1
CYP19A1NO23NR5A1, NR0B1, FOXL2, NR2F1, CREB1, PGR, RARG, SP1, USF2, NR5A2, BRCA1, ESRRA, WT1, JUN, RELA, NFKB1, STAT3, NR3C1, NR2F6, CEBPB, CEBPD, ESR1, USF12NR5A1, NR0B1
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ZFPM2NR5A1No1GATA4
NR0B1NR5A1Yes1NRIP1
NR0B1SRYNo1AR
MAP3K1NR5A1No2UBE2I, JUN
NR5A1SRYNo1SP1
AKR1C4AKR1C2Yes2AKR1C2, AKR1C3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
DHHNR0B1No-1WNT4
ZFPM2NR5A1No-2SRY, GATA4
ZFPM2SRYYesactivation, binding1GATA4
ZFPM2CBX2No-1RBBP4
NR0B1MAP3K1No-1ESR1
NR0B1NR5A1Yesactivation, binding11WT1, AR, NRIP1, NANOG, ESR2, NR4A1, ESR1, CYP19A1, PGR, CTNNB1, PPARA
NR0B1SRYNo-4WT1, AR, NR5A1, CTNNB1
MAP3K1NR5A1No-2JUN, ESR1
NR5A1SRYYesexpression, binding4WT1, AR, GATA4, CTNNB1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolism of xenobiotics by cytochrome P450hsa009806.482AKR1C4, AKR1C2
Steroid hormone biosynthesishsa001406.932AKR1C4, AKR1C2

NET-GE enrichment

Term New enriched termICP valueGenes
Metabolism of xenobiotics by cytochrome P450 (hsa00980) -6.480.011AKR1C4, AKR1C2, NR5A1
Steroid hormone biosynthesis (hsa00140) -6.930.0AKR1C4, AKR1C2, NR5A1, NR0B1
Xenobiotics biodegradation and metabolismNEW5.920.047AKR1C4, AKR1C2, NR5A1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.783SRY, DHH, AKR1C4
Nuclear Receptor transcription pathwayR-HSA-3832807.312NR5A1, NR0B1
Synthesis of bile acids and bile salts via 27-hydroxycholesterolR-HSA-1938079.082AKR1C4, AKR1C2
Generic Transcription PathwayR-HSA-2124363.862NR5A1, NR0B1
Gene ExpressionR-HSA-741602.722NR5A1, NR0B1
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolR-HSA-1933688.42AKR1C4, AKR1C2
Bile acid and bile salt metabolismR-HSA-1940687.852AKR1C4, AKR1C2
Synthesis of bile acids and bile salts via 24-hydroxycholesterolR-HSA-1937759.182AKR1C4, AKR1C2
MetabolismR-HSA-14307282.342AKR1C4, AKR1C2
Synthesis of bile acids and bile saltsR-HSA-1921058.232AKR1C4, AKR1C2
Metabolism of lipids and lipoproteinsR-HSA-5568333.792AKR1C4, AKR1C2

NET-GE enrichment

Term New enriched termICP valueGenes
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (R-HSA-193807) -9.080.007AKR1C4, AKR1C2
Synthesis of bile acids and bile salts (R-HSA-192105) -8.230.022AKR1C4, AKR1C2
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol (R-HSA-193368) -8.40.017AKR1C4, AKR1C2
Bile acid and bile salt metabolism (R-HSA-194068) -7.850.037AKR1C4, AKR1C2
Synthesis of bile acids and bile salts via 24-hydroxycholesterol (R-HSA-193775) -9.180.006AKR1C4, AKR1C2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.188DHH, ZFPM2, MAP3K1, AKR1C2, NR5A1, NR0B1, SRY, CBX2
organic cyclic compound binding (GO:0097159) 1.057ZFPM2, MAP3K1, AKR1C2, NR5A1, NR0B1, SRY, CBX2
protein binding (GO:0005515) 0.467DHH, ZFPM2, MAP3K1, NR5A1, NR0B1, SRY, CBX2
heterocyclic compound binding (GO:1901363) 1.066ZFPM2, MAP3K1, NR5A1, NR0B1, SRY, CBX2
ion binding (GO:0043167) 1.365DHH, ZFPM2, AKR1C2, MAP3K1, NR5A1
nucleic acid binding (GO:0003676) 1.445SRY, ZFPM2, CBX2, NR0B1, NR5A1
DNA binding (GO:0003677) 1.925SRY, ZFPM2, CBX2, NR0B1, NR5A1
cation binding (GO:0043169) 1.44DHH, ZFPM2, MAP3K1, NR5A1
transition metal ion binding (GO:0046914) 2.484DHH, ZFPM2, MAP3K1, NR5A1
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.654SRY, ZFPM2, NR5A1, NR0B1
catalytic activity (GO:0003824) 1.054DHH, AKR1C4, AKR1C2, MAP3K1
nucleic acid binding transcription factor activity (GO:0001071) 2.654SRY, ZFPM2, NR5A1, NR0B1
metal ion binding (GO:0046872) 1.414DHH, ZFPM2, MAP3K1, NR5A1
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.294SRY, ZFPM2, NR5A1, NR0B1
zinc ion binding (GO:0008270) 2.664DHH, ZFPM2, MAP3K1, NR5A1
signal transducer activity (GO:0004871) 2.283MAP3K1, NR5A1, NR0B1
transcription factor binding (GO:0008134) 3.463SRY, ZFPM2, NR0B1
transcription cofactor activity (GO:0003712) 3.443ZFPM2, NR5A1, NR0B1
transcription factor activity, transcription factor binding (GO:0000989) 3.363ZFPM2, NR5A1, NR0B1
transcription factor activity, protein binding (GO:0000988) 3.353ZFPM2, NR5A1, NR0B1
aldo-keto reductase (NADP) activity (GO:0004033) 6.482AKR1C4, AKR1C2
signaling receptor activity (GO:0038023) 2.492NR5A1, NR0B1
enzyme binding (GO:0019899) 2.272MAP3K1, NR5A1
molecular transducer activity (GO:0060089) 2.322NR5A1, NR0B1
transcription factor activity, direct ligand regulated sequence-specific DNA binding (GO:0098531) 5.872NR5A1, NR0B1
macromolecular complex binding (GO:0044877) 2.612CBX2, NR5A1
receptor activity (GO:0004872) 2.322NR5A1, NR0B1
(GO:0047023) 8.352AKR1C4, AKR1C2
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding (GO:0004879) 5.872NR5A1, NR0B1
oxidoreductase activity (GO:0016491) 3.122AKR1C4, AKR1C2
sequence-specific DNA binding (GO:0043565) 2.792NR5A1, NR0B1
transcription corepressor activity (GO:0003714) 4.332ZFPM2, NR0B1
transcription coactivator activity (GO:0003713) 4.042ZFPM2, NR5A1
steroid dehydrogenase activity (GO:0016229) 6.342AKR1C4, AKR1C2
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0033764) 6.482AKR1C4, AKR1C2
lipid binding (GO:0008289) 3.262NR5A1, AKR1C2
receptor binding (GO:0005102) 2.432DHH, NR0B1
oxidoreductase activity, acting on CH-OH group of donors (GO:0016614) 4.832AKR1C4, AKR1C2
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616) 5.02AKR1C4, AKR1C2
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding (GO:0003705) 5.232SRY, NR5A1
steroid hormone receptor activity (GO:0003707) 5.662NR5A1, NR0B1
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor (GO:0016655) 5.662AKR1C4, AKR1C2
oxidoreductase activity, acting on NAD(P)H (GO:0016651) 5.132AKR1C4, AKR1C2
protein dimerization activity (GO:0046983) 2.722SRY, NR0B1
chromatin binding (GO:0003682) 3.642CBX2, NR5A1

NET-GE enrichment

Term New enriched termICP valueGenes
aldo-keto reductase (NADP) activity (GO:0004033) -6.480.02AKR1C4, AKR1C2
direct ligand regulated sequence-specific DNA binding transcription factor activity (GO:0098531) -5.870.038NR5A1, NR0B1
oxidoreductase activity, acting on NAD(P)H (GO:0016651) -5.130.015AKR1C4, AKR1C2, MAP3K1
steroid binding (GO:0005496) NEW5.240.035NR5A1, AKR1C2, NR0B1
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0004879) -5.870.038NR5A1, NR0B1
oxidoreductase activity (GO:0016491) -3.120.018AKR1C2, MAP3K1, AKR1C4, NR5A1, NR0B1, CBX2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
primary metabolic process (GO:0044238) 0.699DHH, AKR1C4, MAP3K1, AKR1C2, ZFPM2, NR5A1, NR0B1, SRY, CBX2
cellular process (GO:0009987) 0.269DHH, AKR1C4, MAP3K1, AKR1C2, ZFPM2, NR5A1, NR0B1, SRY, CBX2
organic substance metabolic process (GO:0071704) 0.639DHH, AKR1C4, MAP3K1, AKR1C2, ZFPM2, NR5A1, NR0B1, SRY, CBX2
biological regulation (GO:0065007) 0.399DHH, AKR1C4, MAP3K1, AKR1C2, ZFPM2, NR5A1, NR0B1, SRY, CBX2
metabolic process (GO:0008152) 0.589DHH, AKR1C4, MAP3K1, AKR1C2, ZFPM2, NR5A1, NR0B1, SRY, CBX2
single-organism cellular process (GO:0044763) 0.659DHH, AKR1C4, MAP3K1, AKR1C2, ZFPM2, NR5A1, NR0B1, SRY, CBX2
single-organism process (GO:0044699) 0.489DHH, AKR1C4, MAP3K1, AKR1C2, ZFPM2, NR5A1, NR0B1, SRY, CBX2
regulation of biological process (GO:0050789) 0.458DHH, ZFPM2, MAP3K1, AKR1C2, NR5A1, NR0B1, SRY, CBX2
cellular metabolic process (GO:0044237) 0.698AKR1C4, MAP3K1, AKR1C2, ZFPM2, NR5A1, NR0B1, SRY, CBX2
regulation of primary metabolic process (GO:0080090) 1.087DHH, ZFPM2, MAP3K1, NR5A1, NR0B1, SRY, CBX2
regulation of metabolic process (GO:0019222) 1.027DHH, ZFPM2, MAP3K1, NR5A1, NR0B1, SRY, CBX2
cellular developmental process (GO:0048869) 1.827DHH, ZFPM2, AKR1C2, NR5A1, NR0B1, SRY, CBX2
cell differentiation (GO:0030154) 2.147DHH, ZFPM2, AKR1C2, NR5A1, NR0B1, SRY, CBX2
regulation of cellular process (GO:0050794) 0.57ZFPM2, MAP3K1, AKR1C2, NR5A1, NR0B1, SRY, CBX2
macromolecule metabolic process (GO:0043170) 0.837DHH, ZFPM2, MAP3K1, NR5A1, NR0B1, SRY, CBX2
organic cyclic compound metabolic process (GO:1901360) 1.267AKR1C4, NR5A1, AKR1C2, ZFPM2, NR0B1, SRY, CBX2
developmental process (GO:0032502) 1.366DHH, ZFPM2, NR5A1, NR0B1, SRY, CBX2
organic substance biosynthetic process (GO:1901576) 1.346AKR1C4, NR5A1, ZFPM2, NR0B1, SRY, CBX2
cellular macromolecule metabolic process (GO:0044260) 0.936ZFPM2, MAP3K1, NR5A1, NR0B1, SRY, CBX2
reproductive process (GO:0022414) 2.556DHH, ZFPM2, NR5A1, NR0B1, SRY, CBX2
regulation of macromolecule metabolic process (GO:0060255) 1.086ZFPM2, MAP3K1, NR5A1, NR0B1, SRY, CBX2
regulation of cellular metabolic process (GO:0031323) 1.076ZFPM2, MAP3K1, NR5A1, NR0B1, SRY, CBX2
regulation of biosynthetic process (GO:0009889) 1.376DHH, ZFPM2, NR5A1, NR0B1, SRY, CBX2
developmental process involved in reproduction (GO:0003006) 3.366DHH, ZFPM2, NR5A1, NR0B1, SRY, CBX2
biosynthetic process (GO:0009058) 1.326AKR1C4, NR5A1, ZFPM2, NR0B1, SRY, CBX2
cellular biosynthetic process (GO:0044249) 1.376AKR1C4, NR5A1, ZFPM2, NR0B1, SRY, CBX2
organic cyclic compound biosynthetic process (GO:1901362) 1.666AKR1C4, NR5A1, ZFPM2, NR0B1, SRY, CBX2
regulation of RNA metabolic process (GO:0051252) 1.525SRY, ZFPM2, CBX2, NR0B1, NR5A1
RNA biosynthetic process (GO:0032774) 1.845SRY, ZFPM2, CBX2, NR0B1, NR5A1
regulation of cellular biosynthetic process (GO:0031326) 1.385SRY, ZFPM2, CBX2, NR0B1, NR5A1
nucleic acid metabolic process (GO:0090304) 1.465SRY, ZFPM2, CBX2, NR0B1, NR5A1
cellular nitrogen compound metabolic process (GO:0034641) 1.225SRY, ZFPM2, CBX2, NR0B1, NR5A1
nitrogen compound metabolic process (GO:0006807) 1.135SRY, ZFPM2, CBX2, NR0B1, NR5A1
cellular macromolecule biosynthetic process (GO:0034645) 1.665SRY, ZFPM2, CBX2, NR0B1, NR5A1
nucleic acid-templated transcription (GO:0097659) 1.915SRY, ZFPM2, CBX2, NR0B1, NR5A1
nucleobase-containing compound metabolic process (GO:0006139) 1.355SRY, ZFPM2, CBX2, NR0B1, NR5A1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465SRY, ZFPM2, CBX2, NR0B1, NR5A1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.245SRY, ZFPM2, CBX2, NR0B1, NR5A1
positive regulation of biological process (GO:0048518) 1.25SRY, ZFPM2, AKR1C2, MAP3K1, NR5A1
negative regulation of biological process (GO:0048519) 1.335SRY, ZFPM2, CBX2, NR0B1, NR5A1
regulation of gene expression (GO:0010468) 1.375SRY, ZFPM2, CBX2, NR0B1, NR5A1
heterocycle biosynthetic process (GO:0018130) 1.75SRY, ZFPM2, CBX2, NR0B1, NR5A1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.435SRY, ZFPM2, CBX2, NR0B1, NR5A1
cellular aromatic compound metabolic process (GO:0006725) 1.35SRY, ZFPM2, CBX2, NR0B1, NR5A1
regulation of nucleic acid-templated transcription (GO:1903506) 1.555SRY, ZFPM2, CBX2, NR0B1, NR5A1
single-organism developmental process (GO:0044767) 1.495SRY, DHH, ZFPM2, NR5A1, NR0B1
macromolecule biosynthetic process (GO:0009059) 1.615SRY, ZFPM2, CBX2, NR0B1, NR5A1
regulation of nitrogen compound metabolic process (GO:0051171) 1.365SRY, ZFPM2, CBX2, NR0B1, NR5A1
regulation of RNA biosynthetic process (GO:2001141) 1.555SRY, ZFPM2, CBX2, NR0B1, NR5A1
nucleobase-containing compound biosynthetic process (GO:0034654) 1.725SRY, ZFPM2, CBX2, NR0B1, NR5A1
heterocycle metabolic process (GO:0046483) 1.315SRY, ZFPM2, CBX2, NR0B1, NR5A1
RNA metabolic process (GO:0016070) 1.595SRY, ZFPM2, CBX2, NR0B1, NR5A1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.595SRY, ZFPM2, CBX2, NR0B1, NR5A1
response to stimulus (GO:0050896) 1.225DHH, AKR1C4, AKR1C2, MAP3K1, NR0B1
anatomical structure development (GO:0048856) 1.585SRY, DHH, ZFPM2, NR5A1, NR0B1
regulation of transcription, DNA-templated (GO:0006355) 1.565SRY, ZFPM2, CBX2, NR0B1, NR5A1
regulation of macromolecule biosynthetic process (GO:0010556) 1.435SRY, ZFPM2, CBX2, NR0B1, NR5A1
transcription, DNA-templated (GO:0006351) 1.915SRY, ZFPM2, CBX2, NR0B1, NR5A1
aromatic compound biosynthetic process (GO:0019438) 1.75SRY, ZFPM2, CBX2, NR0B1, NR5A1
positive regulation of cellular process (GO:0048522) 1.35SRY, ZFPM2, AKR1C2, MAP3K1, NR5A1
negative regulation of metabolic process (GO:0009892) 1.934SRY, ZFPM2, CBX2, NR0B1
positive regulation of metabolic process (GO:0009893) 1.744SRY, ZFPM2, MAP3K1, NR5A1
negative regulation of biosynthetic process (GO:0009890) 2.474SRY, ZFPM2, CBX2, NR0B1
negative regulation of cellular biosynthetic process (GO:0031327) 2.494SRY, ZFPM2, CBX2, NR0B1
positive regulation of cellular metabolic process (GO:0031325) 1.814SRY, ZFPM2, MAP3K1, NR5A1
negative regulation of cellular metabolic process (GO:0031324) 2.014SRY, ZFPM2, CBX2, NR0B1
negative regulation of gene expression (GO:0010629) 2.484SRY, ZFPM2, CBX2, NR0B1
signal transduction (GO:0007165) 1.284MAP3K1, AKR1C2, NR0B1, NR5A1
sex determination (GO:0007530) 6.644SRY, DHH, NR5A1, NR0B1
single-organism metabolic process (GO:0044710) 1.634AKR1C4, AKR1C2, MAP3K1, NR0B1
negative regulation of macromolecule metabolic process (GO:0010605) 2.014SRY, ZFPM2, CBX2, NR0B1
positive regulation of macromolecule metabolic process (GO:0010604) 1.814SRY, ZFPM2, MAP3K1, NR5A1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.124SRY, ZFPM2, CBX2, NR0B1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.64SRY, ZFPM2, CBX2, NR0B1
animal organ development (GO:0048513) 2.534SRY, ZFPM2, NR5A1, NR0B1
regulation of biological quality (GO:0065008) 1.684AKR1C4, AKR1C2, ZFPM2, NR5A1
multicellular organismal process (GO:0032501) 1.454DHH, ZFPM2, AKR1C2, NR5A1
reproductive structure development (GO:0048608) 4.084SRY, ZFPM2, NR5A1, NR0B1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.554SRY, ZFPM2, CBX2, NR0B1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.714SRY, ZFPM2, CBX2, NR0B1
negative regulation of RNA biosynthetic process (GO:1902679) 2.74SRY, ZFPM2, CBX2, NR0B1
negative regulation of transcription, DNA-templated (GO:0045892) 2.754SRY, ZFPM2, CBX2, NR0B1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.474SRY, ZFPM2, CBX2, NR0B1
single organism reproductive process (GO:0044702) 2.734SRY, DHH, NR5A1, NR0B1
single-multicellular organism process (GO:0044707) 1.784DHH, ZFPM2, AKR1C2, NR5A1
negative regulation of RNA metabolic process (GO:0051253) 2.664SRY, ZFPM2, CBX2, NR0B1
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.534SRY, ZFPM2, CBX2, NR0B1
negative regulation of cellular process (GO:0048523) 1.414SRY, ZFPM2, CBX2, NR0B1
positive regulation of biosynthetic process (GO:0009891) 2.293SRY, ZFPM2, NR5A1
positive regulation of reproductive process (GO:2000243) 5.83SRY, ZFPM2, NR5A1
regulation of reproductive process (GO:2000241) 4.883SRY, ZFPM2, NR5A1
regulation of response to stimulus (GO:0048583) 1.543MAP3K1, AKR1C2, NR0B1
male gonad development (GO:0008584) 5.083SRY, NR5A1, NR0B1
positive regulation of gene expression (GO:0010628) 2.353SRY, ZFPM2, NR5A1
regulation of signaling (GO:0023051) 1.723MAP3K1, AKR1C2, NR0B1
regulation of cell communication (GO:0010646) 1.733MAP3K1, AKR1C2, NR0B1
multicellular organism development (GO:0007275) 2.543DHH, ZFPM2, NR5A1
hormone metabolic process (GO:0042445) 4.643AKR1C4, AKR1C2, NR5A1
cellular response to stimulus (GO:0051716) 1.973AKR1C4, AKR1C2, MAP3K1
regulation of male gonad development (GO:2000018) 7.533SRY, ZFPM2, NR5A1
regulation of signal transduction (GO:0009966) 1.843MAP3K1, AKR1C2, NR0B1
positive regulation of multicellular organismal process (GO:0051240) 2.493SRY, ZFPM2, NR5A1
positive regulation of cellular biosynthetic process (GO:0031328) 2.33SRY, ZFPM2, NR5A1
gonad development (GO:0008406) 4.923SRY, NR5A1, NR0B1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.393SRY, ZFPM2, NR5A1
localization (GO:0051179) 1.43AKR1C4, NR5A1, NR0B1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.563SRY, ZFPM2, NR5A1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353SRY, ZFPM2, NR5A1
lipid metabolic process (GO:0006629) 2.683AKR1C4, AKR1C2, NR0B1
male sex determination (GO:0030238) 7.163SRY, DHH, NR0B1
regulation of developmental process (GO:0050793) 2.13SRY, ZFPM2, NR5A1
regulation of hormone levels (GO:0010817) 3.563AKR1C4, AKR1C2, NR5A1
positive regulation of transcription, DNA-templated (GO:0045893) 2.563SRY, ZFPM2, NR5A1
regulation of multicellular organismal process (GO:0051239) 1.873SRY, ZFPM2, NR5A1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293SRY, ZFPM2, NR5A1
response to chemical (GO:0042221) 1.983DHH, AKR1C4, AKR1C2
response to organic substance (GO:0010033) 2.23DHH, AKR1C4, AKR1C2
steroid metabolic process (GO:0008202) 4.323AKR1C4, AKR1C2, NR0B1
response to oxygen-containing compound (GO:1901700) 2.573DHH, AKR1C4, AKR1C2
positive regulation of developmental process (GO:0051094) 2.773SRY, ZFPM2, NR5A1
protein metabolic process (GO:0019538) 1.453DHH, MAP3K1, CBX2
positive regulation of RNA metabolic process (GO:0051254) 2.513SRY, ZFPM2, NR5A1
positive regulation of RNA biosynthetic process (GO:1902680) 2.543SRY, ZFPM2, NR5A1
positive regulation of male gonad development (GO:2000020) 7.653SRY, ZFPM2, NR5A1
regulation of multicellular organismal development (GO:2000026) 2.313SRY, ZFPM2, NR5A1
glycoside metabolic process (GO:0016137) 6.962AKR1C4, AKR1C2
cellular response to chemical stimulus (GO:0070887) 2.572AKR1C4, AKR1C2
Leydig cell differentiation (GO:0033327) 7.332DHH, NR0B1
single organism signaling (GO:0044700) 3.252DHH, NR5A1
negative regulation of reproductive process (GO:2000242) 5.762ZFPM2, NR5A1
positive regulation of response to stimulus (GO:0048584) 2.182MAP3K1, AKR1C2
cofactor metabolic process (GO:0051186) 3.912AKR1C4, AKR1C2
carboxylic acid metabolic process (GO:0019752) 3.122AKR1C4, AKR1C2
cellular response to acid chemical (GO:0071229) 4.672AKR1C4, AKR1C2
positive regulation of signaling (GO:0023056) 2.412MAP3K1, AKR1C2
oxoacid metabolic process (GO:0043436) 3.122AKR1C4, AKR1C2
signaling (GO:0023052) 3.252DHH, NR5A1
small molecule metabolic process (GO:0044281) 2.382AKR1C4, AKR1C2
steroid hormone mediated signaling pathway (GO:0043401) 4.92NR5A1, NR0B1
regulation of lipid biosynthetic process (GO:0046890) 4.872DHH, NR5A1
aminoglycoside antibiotic metabolic process (GO:0030647) 7.532AKR1C4, AKR1C2
positive regulation of cell communication (GO:0010647) 2.412MAP3K1, AKR1C2
regulation of cell differentiation (GO:0045595) 2.422ZFPM2, NR0B1
adrenal gland development (GO:0030325) 6.642NR5A1, NR0B1
response to endogenous stimulus (GO:0009719) 2.792AKR1C4, AKR1C2
cellular protein metabolic process (GO:0044267) 1.632MAP3K1, CBX2
(GO:0044597) 7.652AKR1C4, AKR1C2
intracellular receptor signaling pathway (GO:0030522) 4.62NR5A1, NR0B1
(GO:0009753) 8.342AKR1C4, AKR1C2
positive regulation of signal transduction (GO:0009967) 2.52MAP3K1, AKR1C2
negative regulation of multicellular organismal process (GO:0051241) 2.842ZFPM2, NR5A1
(GO:0044598) 7.652AKR1C4, AKR1C2
quinone metabolic process (GO:1901661) 6.42AKR1C4, AKR1C2
cellular response to organic substance (GO:0071310) 2.782AKR1C4, AKR1C2
single-organism localization (GO:1902578) 2.092AKR1C4, NR5A1
transcription initiation from RNA polymerase II promoter (GO:0006367) 4.72NR5A1, NR0B1
epithelial cell differentiation (GO:0030855) 3.982AKR1C2, NR0B1
regulation of molecular function (GO:0065009) 1.782MAP3K1, NR0B1
cellular response to endogenous stimulus (GO:0071495) 3.332AKR1C4, AKR1C2
hormone-mediated signaling pathway (GO:0009755) 4.662NR5A1, NR0B1
regulation of female gonad development (GO:2000194) 7.242ZFPM2, NR5A1
negative regulation of female gonad development (GO:2000195) 8.342ZFPM2, NR5A1
regulation of lipid metabolic process (GO:0019216) 4.082DHH, NR5A1
regulation of steroid metabolic process (GO:0019218) 5.422DHH, NR5A1
secondary metabolic process (GO:0019748) 5.882AKR1C4, AKR1C2
tissue development (GO:0009888) 3.272ZFPM2, NR5A1
cellular protein modification process (GO:0006464) 1.792MAP3K1, CBX2
(GO:0071395) 8.342AKR1C4, AKR1C2
negative regulation of cell differentiation (GO:0045596) 3.332ZFPM2, NR0B1
macromolecule modification (GO:0043412) 1.732MAP3K1, CBX2
single-organism biosynthetic process (GO:0044711) 2.82AKR1C4, NR0B1
regulation of steroid biosynthetic process (GO:0050810) 5.842DHH, NR5A1
response to acid chemical (GO:0001101) 4.052AKR1C4, AKR1C2
cell-cell signaling (GO:0007267) 3.352DHH, NR5A1
positive regulation of intracellular signal transduction (GO:1902533) 2.952MAP3K1, AKR1C2
cellular lipid metabolic process (GO:0044255) 2.922AKR1C4, AKR1C2
regulation of intracellular signal transduction (GO:1902531) 2.312MAP3K1, AKR1C2
cellular hormone metabolic process (GO:0034754) 5.092AKR1C4, AKR1C2
oxidation-reduction process (GO:0055114) 2.912AKR1C4, AKR1C2
lipid biosynthetic process (GO:0008610) 3.492AKR1C4, NR0B1
negative regulation of developmental process (GO:0051093) 3.172ZFPM2, NR5A1
cellular response to oxygen-containing compound (GO:1901701) 3.222AKR1C4, AKR1C2
sex differentiation (GO:0007548) 6.332SRY, CBX2
cellular ketone metabolic process (GO:0042180) 5.542AKR1C4, AKR1C2
organic acid metabolic process (GO:0006082) 3.012AKR1C4, AKR1C2
response to hormone (GO:0009725) 3.332AKR1C4, AKR1C2
carbohydrate derivative metabolic process (GO:1901135) 3.072AKR1C4, AKR1C2
cellular response to hormone stimulus (GO:0032870) 3.992AKR1C4, AKR1C2
glycosyl compound metabolic process (GO:1901657) 4.042AKR1C4, AKR1C2
cell communication (GO:0007154) 3.042DHH, NR5A1
protein modification process (GO:0036211) 1.792MAP3K1, CBX2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812ZFPM2, NR5A1
steroid biosynthetic process (GO:0006694) 5.062AKR1C4, NR0B1
DNA-templated transcription, initiation (GO:0006352) 4.492NR5A1, NR0B1
polyketide metabolic process (GO:0030638) 7.532AKR1C4, AKR1C2
monocarboxylic acid metabolic process (GO:0032787) 3.572AKR1C4, AKR1C2
gland development (GO:0048732) 4.152NR5A1, NR0B1

NET-GE enrichment

Term New enriched termICP valueGenes
developmental process (GO:0032502) -1.360.039DHH, ZFPM2, MAP3K1, AKR1C2, NR5A1, NR0B1, SRY, CBX2
glycoside metabolic process (GO:0016137) -6.960.012AKR1C4, AKR1C2
adrenal gland development (GO:0030325) -6.640.027NR5A1, NR0B1
Leydig cell differentiation (GO:0033327) -7.330.007DHH, NR0B1
negative regulation of reproductive process (GO:2000242) -5.760.048ZFPM2, NR5A1
doxorubicin metabolic process (GO:0044598) -7.650.003AKR1C4, AKR1C2
cell differentiation (GO:0030154) -2.140.001DHH, ZFPM2, AKR1C2, NR5A1, NR0B1, SRY, CBX2
male gonad development (GO:0008584) -5.080.003SRY, NR5A1, NR0B1
aminoglycoside antibiotic metabolic process (GO:0030647) -7.530.003AKR1C4, AKR1C2
sex determination (GO:0007530) -6.640.0SRY, DHH, NR5A1, NR0B1
response to endogenous stimulus (GO:0009719) -2.790.003DHH, AKR1C4, MAP3K1, AKR1C2, NR5A1, NR0B1
hormone metabolic process (GO:0042445) -4.640.022AKR1C4, AKR1C2, NR5A1
regulation of male gonad development (GO:2000018) -7.530.0SRY, ZFPM2, NR5A1
response to jasmonic acid (GO:0009753) -8.340.001AKR1C4, AKR1C2
cellular developmental process (GO:0048869) -1.820.0DHH, ZFPM2, MAP3K1, AKR1C2, NR5A1, NR0B1, SRY, CBX2
gonad development (GO:0008406) -4.920.007SRY, NR5A1, NR0B1
quinone metabolic process (GO:1901661) -6.40.04AKR1C4, AKR1C2
Sertoli cell differentiation (GO:0060008) NEW7.940.0SRY, NR5A1, NR0B1
positive regulation of reproductive process (GO:2000243) -5.80.0SRY, ZFPM2, NR5A1
cellular response to endogenous stimulus (GO:0071495) -3.330.041AKR1C4, MAP3K1, AKR1C2, NR5A1, NR0B1, SRY, CBX2
regulation of female gonad development (GO:2000194) -7.240.004ZFPM2, NR5A1
negative regulation of female gonad development (GO:2000195) -8.340.001ZFPM2, NR5A1
reproductive structure development (GO:0048608) -4.080.038SRY, ZFPM2, MAP3K1, NR0B1, NR5A1
male sex determination (GO:0030238) -7.160.0SRY, DHH, NR0B1
cellular response to jasmonic acid stimulus (GO:0071395) -8.340.001AKR1C4, AKR1C2
single-organism developmental process (GO:0044767) -1.490.019DHH, ZFPM2, MAP3K1, AKR1C2, NR5A1, NR0B1, SRY, CBX2
reproductive process (GO:0022414) -2.550.001DHH, ZFPM2, NR5A1, NR0B1, SRY, CBX2
cellular response to hormone stimulus (GO:0032870) -3.990.02AKR1C4, AKR1C2, NR0B1, NR5A1
daunorubicin metabolic process (GO:0044597) -7.650.003AKR1C4, AKR1C2
androgen metabolic process (GO:0008209) NEW6.430.006AKR1C4, NR5A1, NR0B1
bile acid metabolic process (GO:0008206) NEW6.150.011AKR1C4, NR5A1, NR0B1
regulation of reproductive process (GO:2000241) -4.880.003SRY, ZFPM2, NR5A1
polyketide metabolic process (GO:0030638) -7.530.003AKR1C4, AKR1C2
cellular ketone metabolic process (GO:0042180) -5.540.036AKR1C4, AKR1C2, NR5A1
developmental process involved in reproduction (GO:0003006) -3.360.0DHH, ZFPM2, MAP3K1, NR5A1, NR0B1, SRY, CBX2
response to hormone (GO:0009725) -3.330.006DHH, AKR1C4, MAP3K1, AKR1C2, NR5A1, NR0B1, CBX2
positive regulation of male gonad development (GO:2000020) -7.650.0SRY, ZFPM2, NR5A1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.119DHH, AKR1C4, MAP3K1, AKR1C2, ZFPM2, NR5A1, NR0B1, SRY, CBX2
intracellular part (GO:0044424) 0.288AKR1C4, MAP3K1, AKR1C2, ZFPM2, NR5A1, NR0B1, SRY, CBX2
cytoplasm (GO:0005737) 1.016AKR1C4, MAP3K1, AKR1C2, ZFPM2, NR0B1, SRY
membrane-bounded organelle (GO:0043227) 0.476AKR1C4, NR5A1, ZFPM2, NR0B1, SRY, CBX2
organelle (GO:0043226) 0.46AKR1C4, NR5A1, ZFPM2, NR0B1, SRY, CBX2
intracellular organelle part (GO:0044446) 0.815SRY, ZFPM2, CBX2, NR0B1, NR5A1
intracellular membrane-bounded organelle (GO:0043231) 0.65SRY, ZFPM2, CBX2, NR0B1, NR5A1
nucleus (GO:0005634) 1.075SRY, ZFPM2, CBX2, NR0B1, NR5A1
nucleoplasm (GO:0005654) 1.895SRY, ZFPM2, CBX2, NR0B1, NR5A1
intracellular organelle (GO:0043229) 0.515SRY, ZFPM2, CBX2, NR0B1, NR5A1
nuclear part (GO:0044428) 1.555SRY, ZFPM2, CBX2, NR0B1, NR5A1
organelle part (GO:0044422) 0.795SRY, ZFPM2, CBX2, NR0B1, NR5A1
macromolecular complex (GO:0032991) 1.354SRY, CBX2, NR5A1, NR0B1
protein complex (GO:0043234) 1.513SRY, CBX2, NR5A1
cytoplasmic part (GO:0044444) 0.823AKR1C4, MAP3K1, NR0B1
nuclear transcription factor complex (GO:0044798) 4.952SRY, NR5A1
membrane (GO:0016020) 0.682DHH, NR0B1
cytosol (GO:0005829) 1.682AKR1C4, MAP3K1
transcription factor complex (GO:0005667) 4.12SRY, NR5A1
extracellular region part (GO:0044421) 1.572DHH, AKR1C4

NET-GE enrichment

Term New enriched termICP valueGenes
nucleoplasm (GO:0005654) -1.890.048ZFPM2, CBX2, NR0B1, NR5A1