Disease table of BASAL GANGLIA CALCIFICATION, IDIOPATHIC OMIM ID: PS213600

Gene-disease associations table

GeneAssociated with BASAL GANGLIA CALCIFICATION, IDIOPATHIC inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SLC20A2ClinVar, OMIM, HUMSAVARHGNC link8p11.211PS213600
PDGFRBClinVar, OMIM, HUMSAVARHGNC link5q325PS228550, 601812, PS213600, 616592, 131440
PDGFBClinVar, OMIM, HUMSAVARHGNC link22q13.13607174, PS213600, 607907
XPR1ClinVar, OMIM, HUMSAVARHGNC link1q25.31PS213600

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PDGFRBYES2ZNF24, TP530
PDGFBYES3SP1, EGR1, ELK10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PDGFRBPDGFBYes3PDGFRA, PDGFB, PDGFRB
PDGFRBXPR1No1NTRK1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SLC20A2PDGFRBNo-1UBC
SLC20A2XPR1No-1UBC
PDGFRBPDGFBYesactivation, binding59PLCG1, ARPC5, RASA1, ABL1, HCK, ITGB3, JAK2, SPHK1, SOS1, EGFR, FYN, ARPC3, LRP1, DNM2, PTPN11, ACTR3, PTPN1, CRK, MLLT4, RAB5A, PIK3CA, PAG1, PTPRJ, FGR, WASL, ARPC1B, NCK1, ANGPT1, PAK1, NCK2, STAT5A, PDGFA, BLK, LCK, HRAS, S1PR1, LYN, STAT5B, DOK1, AKT1, SRC, PDGFRA, GRB2, YES1, ARPC2, STAT3, ITGAV, RAC1, ACTR2, CBL, SLC9A3R1, DOCK4, GRB10, PIK3R1, PTEN, GAB1, VEGFA, SLC9A3R2, BCAR1
PDGFRBXPR1No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
PDGFRBPDGFBYes2PDGFB, PDGFRB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Melanomahsa052186.562PDGFB, PDGFRB
Gap junctionhsa045406.242PDGFB, PDGFRB
MicroRNAs in cancerhsa052065.382PDGFB, PDGFRB
Pathways in cancerhsa052003.982PDGFB, PDGFRB
Gliomahsa052146.662PDGFB, PDGFRB
Prostate cancerhsa052156.112PDGFB, PDGFRB
Rap1 signaling pathwayhsa040154.972PDGFB, PDGFRB
Ras signaling pathwayhsa040144.92PDGFB, PDGFRB
Choline metabolism in cancerhsa052316.092PDGFB, PDGFRB
Focal adhesionhsa045104.922PDGFB, PDGFRB
MAPK signaling pathwayhsa040104.632PDGFB, PDGFRB
HTLV-I infectionhsa051664.592PDGFB, PDGFRB
Regulation of actin cytoskeletonhsa048104.92PDGFB, PDGFRB
Cytokine-cytokine receptor interactionhsa040604.672PDGFB, PDGFRB
PI3K-Akt signaling pathwayhsa041514.212PDGFB, PDGFRB

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) -6.560.003PDGFB, PDGFRB
Gap junction (hsa04540) -6.240.005PDGFB, PDGFRB
MicroRNAs in cancer (hsa05206) -5.380.017PDGFB, PDGFRB
Glioma (hsa05214) -6.660.024PDGFB, PDGFRB
Prostate cancer (hsa05215) -6.110.006PDGFB, PDGFRB
Rap1 signaling pathway (hsa04015) -4.970.03PDGFB, PDGFRB
Ras signaling pathway (hsa04014) -4.90.033PDGFB, PDGFRB
Choline metabolism in cancer (hsa05231) -6.090.006PDGFB, PDGFRB
Focal adhesion (hsa04510) -4.920.032PDGFB, PDGFRB
MAPK signaling pathway (hsa04010) -4.630.047PDGFB, PDGFRB
HTLV-I infection (hsa05166) -4.590.05PDGFB, PDGFRB
Cell motilityNEW4.90.032PDGFB, PDGFRB
Cytokine-cytokine receptor interaction (hsa04060) -4.670.044PDGFB, PDGFRB
Regulation of actin cytoskeleton (hsa04810) -4.90.032PDGFB, PDGFRB
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
PI-3K cascade:FGFR4R-HSA-56547206.372PDGFB, PDGFRB
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.852PDGFB, PDGFRB
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.262PDGFB, PDGFRB
NCAM signaling for neurite out-growthR-HSA-3751654.92PDGFB, PDGFRB
PI3K/AKT activationR-HSA-1982036.322PDGFB, PDGFRB
Signaling by InterleukinsR-HSA-4491474.712PDGFB, PDGFRB
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.992PDGFB, PDGFRB
Immune SystemR-HSA-1682562.372PDGFB, PDGFRB
Frs2-mediated activationR-HSA-1709685.122PDGFB, PDGFRB
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.622PDGFB, PDGFRB
Cytokine Signaling in Immune systemR-HSA-12802153.742PDGFB, PDGFRB
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.952PDGFB, PDGFRB
IGF1R signaling cascadeR-HSA-24289244.852PDGFB, PDGFRB
Downstream signal transductionR-HSA-1867634.652PDGFB, PDGFRB
GAB1 signalosomeR-HSA-1802926.312PDGFB, PDGFRB
IRS-related events triggered by IGF1RR-HSA-24289284.852PDGFB, PDGFRB
Signaling by ERBB4R-HSA-12363944.72PDGFB, PDGFRB
DAP12 interactionsR-HSA-21721274.562PDGFB, PDGFRB
Signaling by Insulin receptorR-HSA-747524.732PDGFB, PDGFRB
Adaptive Immune SystemR-HSA-12802183.192PDGFB, PDGFRB
Developmental BiologyR-HSA-12667383.482PDGFB, PDGFRB
RAF/MAP kinase cascadeR-HSA-56730015.152PDGFB, PDGFRB
Downstream signaling of activated FGFR1R-HSA-56546874.712PDGFB, PDGFRB
MAPK family signaling cascadesR-HSA-56830574.892PDGFB, PDGFRB
Signaling by LeptinR-HSA-25865525.12PDGFB, PDGFRB
Signalling by NGFR-HSA-1665204.232PDGFB, PDGFRB
Signaling by VEGFR-HSA-1941384.662PDGFB, PDGFRB
Signalling to p38 via RIT and RINR-HSA-1877065.122PDGFB, PDGFRB
PI-3K cascade:FGFR1R-HSA-56546896.372PDGFB, PDGFRB
FCERI mediated MAPK activationR-HSA-28717964.322PDGFB, PDGFRB
IRS-mediated signallingR-HSA-1123994.872PDGFB, PDGFRB
FRS-mediated FGFR2 signalingR-HSA-56547005.142PDGFB, PDGFRB
SOS-mediated signallingR-HSA-1124125.152PDGFB, PDGFRB
FRS-mediated FGFR3 signalingR-HSA-56547065.142PDGFB, PDGFRB
DiseaseR-HSA-16436853.332PDGFB, PDGFRB
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.592PDGFB, PDGFRB
Downstream signaling of activated FGFR3R-HSA-56547084.712PDGFB, PDGFRB
Insulin receptor signalling cascadeR-HSA-747514.852PDGFB, PDGFRB
Signaling by FGFR4R-HSA-56547434.692PDGFB, PDGFRB
Signaling by FGFR3R-HSA-56547414.692PDGFB, PDGFRB
VEGFA-VEGFR2 PathwayR-HSA-44200974.72PDGFB, PDGFRB
GRB2 events in ERBB2 signalingR-HSA-19636405.152PDGFB, PDGFRB
Signaling by FGFRR-HSA-1902364.672PDGFB, PDGFRB
PI3K/AKT Signaling in CancerR-HSA-22195286.562PDGFB, PDGFRB
Diseases of signal transductionR-HSA-56632024.892PDGFB, PDGFRB
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032PDGFB, PDGFRB
Interleukin-2 signalingR-HSA-4519275.052PDGFB, PDGFRB
MAPK1/MAPK3 signalingR-HSA-56849965.112PDGFB, PDGFRB
Interleukin receptor SHC signalingR-HSA-9125265.092PDGFB, PDGFRB
Innate Immune SystemR-HSA-1682493.172PDGFB, PDGFRB
Signaling by SCF-KITR-HSA-14335574.732PDGFB, PDGFRB
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.052PDGFB, PDGFRB
Signaling by PDGFR-HSA-1867974.532PDGFB, PDGFRB
Signalling to RASR-HSA-1670445.082PDGFB, PDGFRB
PI3K events in ERBB2 signalingR-HSA-19636426.372PDGFB, PDGFRB
SHC1 events in EGFR signalingR-HSA-1803365.152PDGFB, PDGFRB
SHC1 events in ERBB2 signalingR-HSA-12501965.152PDGFB, PDGFRB
PI-3K cascade:FGFR2R-HSA-56546956.372PDGFB, PDGFRB
Downstream signaling of activated FGFR2R-HSA-56546964.712PDGFB, PDGFRB
SHC1 events in ERBB4 signalingR-HSA-12503475.152PDGFB, PDGFRB
Signaling by EGFRR-HSA-1779294.592PDGFB, PDGFRB
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.512PDGFB, PDGFRB
FRS-mediated FGFR1 signalingR-HSA-56546935.142PDGFB, PDGFRB
Prolonged ERK activation eventsR-HSA-1698935.112PDGFB, PDGFRB
Signalling to ERKsR-HSA-1876875.042PDGFB, PDGFRB
PIP3 activates AKT signalingR-HSA-12576046.372PDGFB, PDGFRB
Signaling by GPCRR-HSA-3727902.682PDGFB, PDGFRB
Signaling by FGFR2R-HSA-56547384.682PDGFB, PDGFRB
GRB2 events in EGFR signalingR-HSA-1798125.152PDGFB, PDGFRB
Signaling by FGFR1R-HSA-56547364.692PDGFB, PDGFRB
PI3K events in ERBB4 signalingR-HSA-12503426.372PDGFB, PDGFRB
ARMS-mediated activationR-HSA-1709845.122PDGFB, PDGFRB
PI-3K cascade:FGFR3R-HSA-56547106.372PDGFB, PDGFRB
FRS-mediated FGFR4 signalingR-HSA-56547125.142PDGFB, PDGFRB
Downstream signaling of activated FGFR4R-HSA-56547164.712PDGFB, PDGFRB
Signaling by ERBB2R-HSA-12279864.662PDGFB, PDGFRB
Axon guidanceR-HSA-4224753.932PDGFB, PDGFRB
VEGFR2 mediated cell proliferationR-HSA-52189215.072PDGFB, PDGFRB
Signal TransductionR-HSA-1625821.782PDGFB, PDGFRB
DAP12 signalingR-HSA-24244914.642PDGFB, PDGFRB

NET-GE enrichment

Term New enriched termICP valueGenes
PIP3 activates AKT signaling (R-HSA-1257604) -6.370.039PDGFB, PDGFRB
PI3K/AKT Signaling in Cancer (R-HSA-2219528) -6.560.03PDGFB, PDGFRB
PI-3K cascade:FGFR4 (R-HSA-5654720) -6.370.039PDGFB, PDGFRB
PI-3K cascade:FGFR1 (R-HSA-5654689) -6.370.039PDGFB, PDGFRB
PI3K events in ERBB4 signaling (R-HSA-1250342) -6.370.039PDGFB, PDGFRB
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530) -7.050.015PDGFB, PDGFRB
PI3K events in ERBB2 signaling (R-HSA-1963642) -6.370.039PDGFB, PDGFRB
PI-3K cascade:FGFR3 (R-HSA-5654710) -6.370.039PDGFB, PDGFRB
GAB1 signalosome (R-HSA-180292) -6.310.043PDGFB, PDGFRB
PI-3K cascade:FGFR2 (R-HSA-5654695) -6.370.039PDGFB, PDGFRB
PI3K/AKT activation (R-HSA-198203) -6.320.042PDGFB, PDGFRB
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
molecular transducer activity (GO:0060089) 2.323XPR1, PDGFRB, SLC20A2
receptor activity (GO:0004872) 2.323XPR1, PDGFRB, SLC20A2
Ras guanyl-nucleotide exchange factor activity (GO:0005088) 4.312PDGFB, PDGFRB
signaling receptor activity (GO:0038023) 2.492XPR1, PDGFRB
phosphatidylinositol 3-kinase activity (GO:0035004) 5.492PDGFB, PDGFRB
platelet-derived growth factor receptor binding (GO:0005161) 7.12PDGFB, PDGFRB
guanyl-nucleotide exchange factor activity (GO:0005085) 4.022PDGFB, PDGFRB
binding (GO:0005488) 0.182PDGFB, PDGFRB
signal transducer activity (GO:0004871) 2.282XPR1, PDGFRB
molecular function regulator (GO:0098772) 2.512PDGFB, PDGFRB
phosphatidylinositol-4,5-bisphosphate 3-kinase activity (GO:0046934) 5.612PDGFB, PDGFRB
G-protein coupled receptor activity (GO:0004930) 2.952XPR1, PDGFRB
growth factor binding (GO:0019838) 4.892PDGFB, PDGFRB
phosphatidylinositol bisphosphate kinase activity (GO:0052813) 5.562PDGFB, PDGFRB
transferase activity (GO:0016740) 1.952PDGFB, PDGFRB
kinase activity (GO:0016301) 2.932PDGFB, PDGFRB
catalytic activity (GO:0003824) 1.052PDGFB, PDGFRB
growth factor receptor binding (GO:0070851) 4.872PDGFB, PDGFRB
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082PDGFB, PDGFRB
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772PDGFB, PDGFRB
virus receptor activity (GO:0001618) 5.492XPR1, SLC20A2
transmembrane signaling receptor activity (GO:0004888) 2.572XPR1, PDGFRB
protein binding (GO:0005515) 0.462PDGFB, PDGFRB
platelet-derived growth factor binding (GO:0048407) 7.342PDGFB, PDGFRB
receptor binding (GO:0005102) 2.432PDGFB, PDGFRB
transmembrane receptor activity (GO:0099600) 2.532XPR1, PDGFRB

NET-GE enrichment

Term New enriched termICP valueGenes
growth factor receptor binding (GO:0070851) -4.870.021PDGFB, PDGFRB
platelet-derived growth factor receptor binding (GO:0005161) -7.10.0PDGFB, PDGFRB
virus receptor activity (GO:0001618) -5.490.008XPR1, SLC20A2
growth factor binding (GO:0019838) -4.890.022PDGFB, PDGFRB
platelet-derived growth factor binding (GO:0048407) -7.340.0PDGFB, PDGFRB
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.264PDGFB, XPR1, PDGFRB, SLC20A2
response to stimulus (GO:0050896) 1.223PDGFB, XPR1, PDGFRB
regulation of cellular process (GO:0050794) 0.53PDGFB, XPR1, PDGFRB
single-organism cellular process (GO:0044763) 0.653PDGFB, XPR1, PDGFRB
signal transduction (GO:0007165) 1.283PDGFB, XPR1, PDGFRB
biological regulation (GO:0065007) 0.393PDGFB, XPR1, PDGFRB
regulation of biological process (GO:0050789) 0.453PDGFB, XPR1, PDGFRB
single-organism process (GO:0044699) 0.483PDGFB, XPR1, PDGFRB
response to abiotic stimulus (GO:0009628) 2.82PDGFB, PDGFRB
regulation of phosphate metabolic process (GO:0019220) 2.352PDGFB, PDGFRB
regulation of primary metabolic process (GO:0080090) 1.082PDGFB, PDGFRB
regulation of metabolic process (GO:0019222) 1.022PDGFB, PDGFRB
regulation of cell cycle process (GO:0010564) 3.52PDGFB, PDGFRB
regulation of transport (GO:0051049) 2.242PDGFB, PDGFRB
positive regulation of response to stimulus (GO:0048584) 2.182PDGFB, PDGFRB
regulation of response to stimulus (GO:0048583) 1.542PDGFB, PDGFRB
regulation of chemotaxis (GO:0050920) 4.532PDGFB, PDGFRB
positive regulation of chemotaxis (GO:0050921) 4.942PDGFB, PDGFRB
cell surface receptor signaling pathway (GO:0007166) 2.092PDGFB, PDGFRB
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242PDGFB, PDGFRB
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542PDGFB, PDGFRB
glycerolipid metabolic process (GO:0046486) 3.912PDGFB, PDGFRB
cellular component organization or biogenesis (GO:0071840) 1.222PDGFB, PDGFRB
single-organism metabolic process (GO:0044710) 1.632PDGFB, PDGFRB
regulation of localization (GO:0032879) 1.942PDGFB, PDGFRB
positive regulation of cell cycle (GO:0045787) 3.942PDGFB, PDGFRB
taxis (GO:0042330) 4.032PDGFB, PDGFRB
regulation of signal transduction (GO:0009966) 1.842PDGFB, PDGFRB
positive regulation of signal transduction (GO:0009967) 2.52PDGFB, PDGFRB
regulation of organelle organization (GO:0033043) 2.722PDGFB, PDGFRB
peptidyl-tyrosine modification (GO:0018212) 4.472PDGFB, PDGFRB
response to growth factor (GO:0070848) 4.142PDGFB, PDGFRB
peptidyl-amino acid modification (GO:0018193) 2.982PDGFB, PDGFRB
regulation of calcium ion import (GO:0090279) 5.082PDGFB, PDGFRB
interspecies interaction between organisms (GO:0044419) 3.082XPR1, SLC20A2
positive regulation of lipid metabolic process (GO:0045834) 4.882PDGFB, PDGFRB
positive regulation of molecular function (GO:0044093) 2.232PDGFB, PDGFRB
phosphorylation (GO:0016310) 2.632PDGFB, PDGFRB
positive regulation of biological process (GO:0048518) 1.22PDGFB, PDGFRB
negative regulation of biological process (GO:0048519) 1.332PDGFB, PDGFRB
regulation of mitotic nuclear division (GO:0007088) 4.832PDGFB, PDGFRB
regulation of cell proliferation (GO:0042127) 2.412PDGFB, PDGFRB
regulation of smooth muscle cell proliferation (GO:0048660) 5.12PDGFB, PDGFRB
positive regulation of DNA metabolic process (GO:0051054) 4.492PDGFB, PDGFRB
chemotaxis (GO:0006935) 4.042PDGFB, PDGFRB
positive regulation of transport (GO:0051050) 2.92PDGFB, PDGFRB
regulation of macromolecule metabolic process (GO:0060255) 1.082PDGFB, PDGFRB
regulation of protein kinase activity (GO:0045859) 3.152PDGFB, PDGFRB
positive regulation of phospholipid metabolic process (GO:1903727) 5.992PDGFB, PDGFRB
regulation of cellular protein metabolic process (GO:0032268) 1.992PDGFB, PDGFRB
phosphatidylinositol metabolic process (GO:0046488) 4.462PDGFB, PDGFRB
interaction with host (GO:0051701) 4.862XPR1, SLC20A2
response to organic substance (GO:0010033) 2.22PDGFB, PDGFRB
multi-organism process (GO:0051704) 2.652XPR1, SLC20A2
regulation of phosphorylation (GO:0042325) 2.52PDGFB, PDGFRB
positive regulation of phosphorylation (GO:0042327) 2.92PDGFB, PDGFRB
regulation of biological quality (GO:0065008) 1.682PDGFB, XPR1
regulation of phosphatidylinositol 3-kinase activity (GO:0043551) 6.022PDGFB, PDGFRB
single-multicellular organism process (GO:0044707) 1.782PDGFB, PDGFRB
positive regulation of MAP kinase activity (GO:0043406) 4.392PDGFB, PDGFRB
protein metabolic process (GO:0019538) 1.452PDGFB, PDGFRB
cell motility (GO:0048870) 3.022PDGFB, PDGFRB
positive regulation of organelle organization (GO:0010638) 3.382PDGFB, PDGFRB
regulation of nuclear division (GO:0051783) 4.672PDGFB, PDGFRB
positive regulation of nuclear division (GO:0051785) 5.722PDGFB, PDGFRB
organophosphate metabolic process (GO:0019637) 3.042PDGFB, PDGFRB
viral entry into host cell (GO:0046718) 5.352XPR1, SLC20A2
positive regulation of mitotic nuclear division (GO:0045840) 5.942PDGFB, PDGFRB
positive regulation of metabolic process (GO:0009893) 1.742PDGFB, PDGFRB
positive regulation of biosynthetic process (GO:0009891) 2.292PDGFB, PDGFRB
positive regulation of kidney development (GO:0090184) 6.022PDGFB, PDGFRB
cell chemotaxis (GO:0060326) 4.632PDGFB, PDGFRB
positive regulation of cell migration (GO:0030335) 3.772PDGFB, PDGFRB
movement of cell or subcellular component (GO:0006928) 2.612PDGFB, PDGFRB
metabolic process (GO:0008152) 0.582PDGFB, PDGFRB
platelet-derived growth factor receptor signaling pathway (GO:0048008) 6.152PDGFB, PDGFRB
nitrogen compound metabolic process (GO:0006807) 1.132PDGFB, PDGFRB
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway (GO:0035793) 8.632PDGFB, PDGFRB
positive regulation of smooth muscle cell proliferation (GO:0048661) 5.62PDGFB, PDGFRB
platelet-derived growth factor receptor-beta signaling pathway (GO:0035791) 7.652PDGFB, PDGFRB
regulation of smooth muscle cell migration (GO:0014910) 5.842PDGFB, PDGFRB
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.062PDGFB, PDGFRB
intracellular signal transduction (GO:0035556) 2.392PDGFB, PDGFRB
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582PDGFB, PDGFRB
cellular protein metabolic process (GO:0044267) 1.632PDGFB, PDGFRB
regulation of mitotic cell cycle (GO:0007346) 3.712PDGFB, PDGFRB
positive regulation of transferase activity (GO:0051347) 3.312PDGFB, PDGFRB
positive regulation of GTPase activity (GO:0043547) 3.282PDGFB, PDGFRB
positive regulation of hydrolase activity (GO:0051345) 2.912PDGFB, PDGFRB
regulation of kinase activity (GO:0043549) 3.072PDGFB, PDGFRB
cellular component organization (GO:0016043) 1.242PDGFB, PDGFRB
regulation of signaling (GO:0023051) 1.722PDGFB, PDGFRB
signal transduction by protein phosphorylation (GO:0023014) 3.792PDGFB, PDGFRB
phosphatidylinositol phosphorylation (GO:0046854) 5.192PDGFB, PDGFRB
regulation of molecular function (GO:0065009) 1.782PDGFB, PDGFRB
cell migration (GO:0016477) 3.122PDGFB, PDGFRB
G-protein coupled receptor signaling pathway (GO:0007186) 2.642XPR1, PDGFRB
positive regulation of cellular component organization (GO:0051130) 2.682PDGFB, PDGFRB
positive regulation of catalytic activity (GO:0043085) 2.42PDGFB, PDGFRB
positive regulation of reactive oxygen species metabolic process (GO:2000379) 5.292PDGFB, PDGFRB
lipid metabolic process (GO:0006629) 2.682PDGFB, PDGFRB
positive regulation of lipid kinase activity (GO:0090218) 6.232PDGFB, PDGFRB
regulation of developmental process (GO:0050793) 2.12PDGFB, PDGFRB
regulation of DNA biosynthetic process (GO:2000278) 5.172PDGFB, PDGFRB
regulation of biosynthetic process (GO:0009889) 1.372PDGFB, PDGFRB
cellular response to stimulus (GO:0051716) 1.972PDGFB, PDGFRB
wound healing (GO:0042060) 5.132PDGFB, PDGFRB
regulation of reactive oxygen species metabolic process (GO:2000377) 4.712PDGFB, PDGFRB
positive regulation of MAPK cascade (GO:0043410) 3.572PDGFB, PDGFRB
macromolecule modification (GO:0043412) 1.732PDGFB, PDGFRB
protein modification process (GO:0036211) 1.792PDGFB, PDGFRB
regulation of multicellular organismal process (GO:0051239) 1.872PDGFB, PDGFRB
positive regulation of intracellular signal transduction (GO:1902533) 2.952PDGFB, PDGFRB
establishment of localization (GO:0051234) 1.482PDGFB, SLC20A2
phosphatidylinositol-mediated signaling (GO:0048015) 4.932PDGFB, PDGFRB
inositol lipid-mediated signaling (GO:0048017) 4.912PDGFB, PDGFRB
positive regulation of macromolecule metabolic process (GO:0010604) 1.812PDGFB, PDGFRB
regulation of hydrolase activity (GO:0051336) 2.532PDGFB, PDGFRB
single-organism developmental process (GO:0044767) 1.492PDGFB, PDGFRB
positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552) 6.292PDGFB, PDGFRB
positive regulation of protein modification process (GO:0031401) 2.72PDGFB, PDGFRB
response to stress (GO:0006950) 1.82PDGFB, PDGFRB
regulation of transferase activity (GO:0051338) 2.882PDGFB, PDGFRB
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392PDGFB, PDGFRB
regulation of macromolecule biosynthetic process (GO:0010556) 1.432PDGFB, PDGFRB
regulation of cell motility (GO:2000145) 3.162PDGFB, PDGFRB
positive regulation of cell motility (GO:2000147) 3.742PDGFB, PDGFRB
response to wounding (GO:0009611) 4.392PDGFB, PDGFRB
positive regulation of multicellular organismal process (GO:0051240) 2.492PDGFB, PDGFRB
positive regulation of response to external stimulus (GO:0032103) 4.172PDGFB, PDGFRB
regulation of response to external stimulus (GO:0032101) 3.062PDGFB, PDGFRB
MAPK cascade (GO:0000165) 3.912PDGFB, PDGFRB
regulation of cellular component organization (GO:0051128) 2.012PDGFB, PDGFRB
positive regulation of signaling (GO:0023056) 2.412PDGFB, PDGFRB
entry into host cell (GO:0030260) 5.32XPR1, SLC20A2
regulation of MAP kinase activity (GO:0043405) 3.952PDGFB, PDGFRB
regulation of phosphorus metabolic process (GO:0051174) 2.352PDGFB, PDGFRB
cellular response to chemical stimulus (GO:0070887) 2.572PDGFB, PDGFRB
regulation of phospholipid metabolic process (GO:1903725) 5.692PDGFB, PDGFRB
positive regulation of cell communication (GO:0010647) 2.412PDGFB, PDGFRB
regulation of cell communication (GO:0010646) 1.732PDGFB, PDGFRB
regulation of GTPase activity (GO:0043087) 3.212PDGFB, PDGFRB
response to organic cyclic compound (GO:0014070) 3.072PDGFB, PDGFRB
regulation of MAPK cascade (GO:0043408) 3.222PDGFB, PDGFRB
response to endogenous stimulus (GO:0009719) 2.792PDGFB, PDGFRB
regulation of intracellular signal transduction (GO:1902531) 2.312PDGFB, PDGFRB
positive regulation of calcium ion import (GO:0090280) 5.722PDGFB, PDGFRB
positive regulation of phosphorus metabolic process (GO:0010562) 2.782PDGFB, PDGFRB
positive regulation of kinase activity (GO:0033674) 3.542PDGFB, PDGFRB
regulation of protein metabolic process (GO:0051246) 1.932PDGFB, PDGFRB
positive regulation of protein metabolic process (GO:0051247) 2.432PDGFB, PDGFRB
lipid phosphorylation (GO:0046834) 5.132PDGFB, PDGFRB
positive regulation of cellular protein metabolic process (GO:0032270) 2.492PDGFB, PDGFRB
transport (GO:0006810) 1.512PDGFB, SLC20A2
regulation of protein modification process (GO:0031399) 2.322PDGFB, PDGFRB
positive regulation of DNA biosynthetic process (GO:2000573) 5.652PDGFB, PDGFRB
positive regulation of cell proliferation (GO:0008284) 3.012PDGFB, PDGFRB
locomotion (GO:0040011) 2.912PDGFB, PDGFRB
phospholipid metabolic process (GO:0006644) 3.882PDGFB, PDGFRB
multicellular organismal process (GO:0032501) 1.452PDGFB, PDGFRB
primary metabolic process (GO:0044238) 0.692PDGFB, PDGFRB
positive regulation of cell cycle process (GO:0090068) 4.252PDGFB, PDGFRB
regulation of kidney development (GO:0090183) 5.722PDGFB, PDGFRB
positive regulation of ion transport (GO:0043270) 4.362PDGFB, PDGFRB
regulation of cellular component movement (GO:0051270) 3.082PDGFB, PDGFRB
positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068) 5.592PDGFB, PDGFRB
cellular lipid metabolic process (GO:0044255) 2.922PDGFB, PDGFRB
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.792PDGFB, PDGFRB
lipid modification (GO:0030258) 4.372PDGFB, PDGFRB
regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway (GO:1900238) 8.632PDGFB, PDGFRB
cellular response to growth factor stimulus (GO:0071363) 4.272PDGFB, PDGFRB
positive regulation of developmental process (GO:0051094) 2.772PDGFB, PDGFRB
regulation of cell cycle (GO:0051726) 2.932PDGFB, PDGFRB
positive regulation of metanephros development (GO:0072216) 7.092PDGFB, PDGFRB
macromolecule biosynthetic process (GO:0009059) 1.612PDGFB, PDGFRB
macromolecule metabolic process (GO:0043170) 0.832PDGFB, PDGFRB
entry into other organism involved in symbiotic interaction (GO:0051828) 5.32XPR1, SLC20A2
organic substance biosynthetic process (GO:1901576) 1.342PDGFB, PDGFRB
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562PDGFB, PDGFRB
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232PDGFB, PDGFRB
developmental process (GO:0032502) 1.362PDGFB, PDGFRB
regulation of calcium ion transport (GO:0051924) 4.382PDGFB, PDGFRB
glycerophospholipid metabolic process (GO:0006650) 4.132PDGFB, PDGFRB
positive regulation of cellular biosynthetic process (GO:0031328) 2.32PDGFB, PDGFRB
positive regulation of smooth muscle cell migration (GO:0014911) 6.332PDGFB, PDGFRB
regulation of cellular biosynthetic process (GO:0031326) 1.382PDGFB, PDGFRB
positive regulation of cellular metabolic process (GO:0031325) 1.812PDGFB, PDGFRB
regulation of cellular metabolic process (GO:0031323) 1.072PDGFB, PDGFRB
peptidyl-tyrosine phosphorylation (GO:0018108) 4.482PDGFB, PDGFRB
regulation of lipid kinase activity (GO:0043550) 5.842PDGFB, PDGFRB
multicellular organism development (GO:0007275) 2.542PDGFB, PDGFRB
regulation of ion transport (GO:0043269) 3.42PDGFB, PDGFRB
regulation of DNA metabolic process (GO:0051052) 3.872PDGFB, PDGFRB
response to estradiol (GO:0032355) 4.732PDGFB, PDGFRB
response to lipid (GO:0033993) 3.112PDGFB, PDGFRB
positive regulation of protein kinase activity (GO:0045860) 3.612PDGFB, PDGFRB
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462PDGFB, PDGFRB
regulation of catalytic activity (GO:0050790) 1.972PDGFB, PDGFRB
organic substance metabolic process (GO:0071704) 0.632PDGFB, PDGFRB
cellular response to organic substance (GO:0071310) 2.782PDGFB, PDGFRB
positive regulation of metanephric mesenchymal cell migration (GO:2000591) 8.632PDGFB, PDGFRB
positive regulation of mitotic cell cycle (GO:0045931) 4.982PDGFB, PDGFRB
protein phosphorylation (GO:0006468) 2.892PDGFB, PDGFRB
regulation of cell migration (GO:0030334) 3.232PDGFB, PDGFRB
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352PDGFB, PDGFRB
positive regulation of phosphate metabolic process (GO:0045937) 2.782PDGFB, PDGFRB
regulation of lipid metabolic process (GO:0019216) 4.082PDGFB, PDGFRB
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432PDGFB, PDGFRB
cellular protein modification process (GO:0006464) 1.792PDGFB, PDGFRB
regulation of metal ion transport (GO:0010959) 3.942PDGFB, PDGFRB
biosynthetic process (GO:0009058) 1.322PDGFB, PDGFRB
multi-organism cellular process (GO:0044764) 3.142XPR1, SLC20A2
regulation of nitrogen compound metabolic process (GO:0051171) 1.362PDGFB, PDGFRB
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292PDGFB, PDGFRB
response to estrogen (GO:0043627) 5.252PDGFB, PDGFRB
response to chemical (GO:0042221) 1.982PDGFB, PDGFRB
localization (GO:0051179) 1.42PDGFB, SLC20A2
response to oxygen levels (GO:0070482) 4.022PDGFB, PDGFRB
response to oxygen-containing compound (GO:1901700) 2.572PDGFB, PDGFRB
positive regulation of cellular component movement (GO:0051272) 3.712PDGFB, PDGFRB
regulation of locomotion (GO:0040012) 3.122PDGFB, PDGFRB
cellular macromolecule metabolic process (GO:0044260) 0.932PDGFB, PDGFRB
positive regulation of locomotion (GO:0040017) 3.712PDGFB, PDGFRB
positive regulation of calcium ion transport (GO:0051928) 5.062PDGFB, PDGFRB
anatomical structure development (GO:0048856) 1.582PDGFB, PDGFRB
cellular metabolic process (GO:0044237) 0.692PDGFB, PDGFRB
phosphate-containing compound metabolic process (GO:0006796) 2.162PDGFB, PDGFRB
entry into host (GO:0044409) 5.32XPR1, SLC20A2
regulation of multicellular organismal development (GO:2000026) 2.312PDGFB, PDGFRB
regulation of metanephros development (GO:0072215) 6.592PDGFB, PDGFRB
viral process (GO:0016032) 3.152XPR1, SLC20A2
phosphorus metabolic process (GO:0006793) 2.152PDGFB, PDGFRB
regulation of metanephric mesenchymal cell migration (GO:2000589) 8.342PDGFB, PDGFRB
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152XPR1, SLC20A2
entry into cell of other organism involved in symbiotic interaction (GO:0051806) 5.32XPR1, SLC20A2
regulation of protein phosphorylation (GO:0001932) 2.572PDGFB, PDGFRB
positive regulation of protein phosphorylation (GO:0001934) 2.952PDGFB, PDGFRB
negative regulation of cellular process (GO:0048523) 1.412PDGFB, PDGFRB
positive regulation of cellular process (GO:0048522) 1.32PDGFB, PDGFRB

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of mitosis (GO:0045840) -5.940.014PDGFB, PDGFRB
positive regulation of smooth muscle cell migration (GO:0014911) -6.330.002PDGFB, PDGFRB
regulation of smooth muscle cell migration (GO:0014910) -5.840.01PDGFB, PDGFRB
regulation of kidney development (GO:0090183) -5.720.026PDGFB, PDGFRB
regulation of protein autophosphorylation (GO:0031952) NEW6.170.049PDGFB, PDGFRB
platelet-derived growth factor receptor signaling pathway (GO:0048008) -6.150.04PDGFB, PDGFRB
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway (GO:0035793) -8.630.0PDGFB, PDGFRB
platelet-derived growth factor receptor-beta signaling pathway (GO:0035791) -7.650.0PDGFB, PDGFRB
positive regulation of transmembrane transport (GO:0034764) NEW4.990.012PDGFB, PDGFRB
positive regulation of ion transmembrane transport (GO:0034767) NEW5.050.01PDGFB, PDGFRB
metanephric glomerular mesangial cell proliferation involved in metanephros development (GO:0072262) NEW9.730.0PDGFB, PDGFRB
cell proliferation involved in kidney development (GO:0072111) NEW7.430.001PDGFB, PDGFRB
glomerular mesangial cell proliferation (GO:0072110) NEW9.040.0PDGFB, PDGFRB
positive regulation of calcium ion import (GO:0090280) -5.720.002PDGFB, PDGFRB
cell proliferation involved in metanephros development (GO:0072203) NEW7.780.001PDGFB, PDGFRB
positive regulation of metanephric mesenchymal cell migration (GO:2000591) -8.630.0PDGFB, PDGFRB
positive regulation of DNA biosynthetic process (GO:2000573) -5.650.004PDGFB, PDGFRB
negative regulation of phospholipid biosynthetic process (GO:0071072) NEW8.630.001PDGFB, PDGFRB
regulation of phospholipid biosynthetic process (GO:0071071) NEW7.330.007PDGFB, PDGFRB
positive regulation of reactive oxygen species metabolic process (GO:2000379) -5.290.014PDGFB, PDGFRB
positive regulation of lipid kinase activity (GO:0090218) -6.230.027PDGFB, PDGFRB
positive regulation of smooth muscle cell proliferation (GO:0048661) -5.60.02PDGFB, PDGFRB
regulation of DNA biosynthetic process (GO:2000278) -5.170.009PDGFB, PDGFRB
positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552) -6.290.006PDGFB, PDGFRB
muscle cell migration (GO:0014812) NEW6.840.021PDGFB, PDGFRB
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) -4.790.042PDGFB, PDGFRB
regulation of calcium ion import (GO:0090279) -5.080.041PDGFB, PDGFRB
regulation of phosphatidylinositol 3-kinase activity (GO:0043551) -6.020.012PDGFB, PDGFRB
regulation of lipid kinase activity (GO:0043550) -5.840.018PDGFB, PDGFRB
regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway (GO:1900238) -8.630.0PDGFB, PDGFRB
response to external stimulus (GO:0009605) NEW2.550.016PDGFB, XPR1, PDGFRB, SLC20A2
regulation of metanephros development (GO:0072215) -6.590.005PDGFB, PDGFRB
positive regulation of nuclear division (GO:0051785) -5.720.025PDGFB, PDGFRB
regulation of metanephric mesenchymal cell migration (GO:2000589) -8.340.0PDGFB, PDGFRB
positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068) -5.590.025PDGFB, PDGFRB
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.114PDGFB, XPR1, PDGFRB, SLC20A2
membrane (GO:0016020) 0.684PDGFB, XPR1, PDGFRB, SLC20A2
plasma membrane part (GO:0044459) 1.954PDGFB, XPR1, PDGFRB, SLC20A2
membrane part (GO:0044425) 0.954PDGFB, XPR1, PDGFRB, SLC20A2
intrinsic component of plasma membrane (GO:0031226) 2.533XPR1, PDGFRB, SLC20A2
integral component of membrane (GO:0016021) 1.143XPR1, PDGFRB, SLC20A2
extracellular region part (GO:0044421) 1.573PDGFB, PDGFRB, SLC20A2
cytoplasmic part (GO:0044444) 0.823PDGFB, XPR1, PDGFRB
plasma membrane (GO:0005886) 1.393XPR1, PDGFRB, SLC20A2
intracellular part (GO:0044424) 0.283PDGFB, XPR1, PDGFRB
membrane-bounded organelle (GO:0043227) 0.473XPR1, PDGFRB, SLC20A2
organelle (GO:0043226) 0.43XPR1, PDGFRB, SLC20A2
intrinsic component of membrane (GO:0031224) 1.133XPR1, PDGFRB, SLC20A2
cytoplasm (GO:0005737) 1.012PDGFB, PDGFRB
plasma membrane region (GO:0098590) 2.972PDGFB, PDGFRB
extracellular organelle (GO:0043230) 1.892PDGFRB, SLC20A2
extracellular exosome (GO:0070062) 1.892PDGFRB, SLC20A2
organelle lumen (GO:0043233) 3.052PDGFB, PDGFRB
membrane-enclosed lumen (GO:0031974) 3.052PDGFB, PDGFRB
membrane-bounded vesicle (GO:0031988) 1.712PDGFRB, SLC20A2
intracellular organelle part (GO:0044446) 0.812PDGFB, PDGFRB
intracellular organelle lumen (GO:0070013) 3.052PDGFB, PDGFRB
intracellular organelle (GO:0043229) 0.512XPR1, PDGFRB
integral component of plasma membrane (GO:0005887) 2.572XPR1, SLC20A2
intracellular membrane-bounded organelle (GO:0043231) 0.62XPR1, PDGFRB
extracellular vesicle (GO:1903561) 1.892PDGFRB, SLC20A2
organelle part (GO:0044422) 0.792PDGFB, PDGFRB
vesicle (GO:0031982) 1.642PDGFRB, SLC20A2

NET-GE enrichment

Term New enriched termICP valueGenes
microvillus (GO:0005902) NEW5.690.048PDGFB, PDGFRB
plasma membrane part (GO:0044459) -1.950.012PDGFB, XPR1, PDGFRB, SLC20A2