Disease table of MENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO OMIM ID: 607174

Gene-disease associations table

GeneAssociated with MENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PDGFBOMIMHGNC link22q13.13607174, PS213600, 607907
MN1OMIMHGNC link22q12.11607174
PTENOMIMHGNC link10q23.3110276950, 608089, 275355, 176807, PS155600, PS137800, 605309, 607174, 153480, PS158350
SMARCE1OMIMHGNC link17q21.23607174, PS135900, PS156200
SUFUOMIMHGNC link10q24.323607174, 155255, 109400
NF2OMIMHGNC link22q12.23607174, 101000, PS162091

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
22q122NF2, MN1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
22q13PDGFB, NF2, MN1
10q22PTEN, SUFU
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
10q2PTEN, SUFU
22q3PDGFB, NF2, MN1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
102PTEN, SUFU
223PDGFB, NF2, MN1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12PDGFB, PTEN
EGR1NO90ATF3, PTEN, IFNG, EGFR, PDGFB, RAG2, SLC9A3, IMPDH2, SYN1, TP53, FCER2, IL2, SYN2, FAP, CHGA, GGPS1, PSEN2, SOX18, AR, GDF15, SLC4A2, LMTK2, TFPI2, MYB, TMPO, POR, FGF2, PTP4A1, PTGS2, CCND2, IL2RB, TNF, PCSK2, ALOX5, HSD11B2, ACHE, TNFSF10, TOE1, DMRT1, LHB, F3, ABCB1, STMN1, PLAUR, BCAR1, TP73, HIF1A, TGFBR2, ID3, AKR1B1, RBL2, TBXA2R, HYAL1, CACNA1H, LTB, CDK5R1, CD28, TCF4, CCND1, LDLR, MMP14, KLK3, GDNF, EAPP, PTGES, STIM1, SPRY1, VEGFA, EP300, CXCL8, NAB2, IGF2, FLT1, PDGFC, HPSE, WNT4, FN1, PLAU, ACE, UBE2S, FAS, CYP2B6, CDKN1A, SOD1, FASLG, NFKB1, IL3, IL6, LAT, PPARG2PDGFB, PTEN
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PDGFBYES3SP1, EGR1, ELK10
PTENYES15SP1, STAT3, EGR1, TCF4, NFKB1, MTA1, AR, TP53, HES1, TFAP2A, RELA, RBPJ, MXD1, PPARG, SRF0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PDGFBPTENNo2PDGFRA, PDGFRB
MN1PTENNo1NCOA3
PTENSMARCE1No2AR, ESR1
PTENNF2No27IRS4, PRDX1, RPS3, RPS4X, TUBA1C, SLC25A5, MVP, SPTBN1, DDB1, DBN1, RPL13, S100A8, RPL14, SLC25A3, SLC9A3R1, AKT1, PXN, SDCBP, DNAJA1, RPL13A, DBT, RCC2, G3BP2, S100A9, LATS1, AMOT, RPS2
SMARCE1NF2No4NXF1, HDAC1, AMOTL2, MOV10

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PDGFBPTENYesactivation, binding21GRB2, SLC9A3R2, AKT1, PDGFRB, NGFR, CBL, BCAR1, THBS1, PIK3R1, SOS1, SRC, SLC9A3R1, INSR, INSRR, PIK3CA, EGFR, TGFB1, PDGFRA, VEGFA, IGF1R, HIF1A
PDGFBSMARCE1No-1SRC
PDGFBNF2No-2SLC9A3R1, AKT1
PTENSMARCE1No-8KAT2B, AR, SMARCA4, ATF2, UBC, JUN, ESR1, SRC
PTENSUFUNo-1TP53
PTENNF2No-5PXN, UBC, CCND1, SLC9A3R1, AKT1
SMARCE1NF2No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathways in cancerhsa052003.983PDGFB, SUFU, PTEN
Melanomahsa052186.562PDGFB, PTEN
MicroRNAs in cancerhsa052065.382PDGFB, PTEN
Gliomahsa052146.662PDGFB, PTEN
Prostate cancerhsa052156.112PDGFB, PTEN
Focal adhesionhsa045104.922PDGFB, PTEN
PI3K-Akt signaling pathwayhsa041514.212PDGFB, PTEN

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) -6.560.028PDGFB, PTEN
Cancers: Specific typesNEW4.10.033PDGFB, SUFU, PTEN
Pathways in cancer (hsa05200) -3.980.041PDGFB, SUFU, PTEN
Glioma (hsa05214) -6.660.025PDGFB, PTEN
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.784NF2, PDGFB, SUFU, PTEN
PI3K/AKT activationR-HSA-1982036.322PDGFB, PTEN
Immune SystemR-HSA-1682562.372PDGFB, PTEN
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.622PDGFB, PTEN
Downstream signal transductionR-HSA-1867634.652PDGFB, PTEN
GAB1 signalosomeR-HSA-1802926.312PDGFB, PTEN
Signaling by ERBB4R-HSA-12363944.72PDGFB, PTEN
Adaptive Immune SystemR-HSA-12802183.192PDGFB, PTEN
DiseaseR-HSA-16436853.332PDGFB, PTEN
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.952PDGFB, PTEN
Downstream signaling of activated FGFR1R-HSA-56546874.712PDGFB, PTEN
Signalling by NGFR-HSA-1665204.232PDGFB, PTEN
PI-3K cascade:FGFR4R-HSA-56547206.372PDGFB, PTEN
PI-3K cascade:FGFR1R-HSA-56546896.372PDGFB, PTEN
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.592PDGFB, PTEN
Downstream signaling of activated FGFR3R-HSA-56547084.712PDGFB, PTEN
Signaling by FGFR4R-HSA-56547434.692PDGFB, PTEN
Signaling by FGFR3R-HSA-56547414.692PDGFB, PTEN
Signaling by FGFRR-HSA-1902364.672PDGFB, PTEN
PI3K/AKT Signaling in CancerR-HSA-22195286.562PDGFB, PTEN
Diseases of signal transductionR-HSA-56632024.892PDGFB, PTEN
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032PDGFB, PTEN
Innate Immune SystemR-HSA-1682493.172PDGFB, PTEN
Signaling by SCF-KITR-HSA-14335574.732PDGFB, PTEN
Signaling by ERBB2R-HSA-12279864.662PDGFB, PTEN
PI3K events in ERBB2 signalingR-HSA-19636426.372PDGFB, PTEN
PI-3K cascade:FGFR2R-HSA-56546956.372PDGFB, PTEN
Downstream signaling of activated FGFR2R-HSA-56546964.712PDGFB, PTEN
Signaling by EGFRR-HSA-1779294.592PDGFB, PTEN
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.512PDGFB, PTEN
PIP3 activates AKT signalingR-HSA-12576046.372PDGFB, PTEN
Signaling by FGFR2R-HSA-56547384.682PDGFB, PTEN
Signaling by FGFR1R-HSA-56547364.692PDGFB, PTEN
PI3K events in ERBB4 signalingR-HSA-12503426.372PDGFB, PTEN
PI-3K cascade:FGFR3R-HSA-56547106.372PDGFB, PTEN
DAP12 interactionsR-HSA-21721274.562PDGFB, PTEN
Downstream signaling of activated FGFR4R-HSA-56547164.712PDGFB, PTEN
Signaling by PDGFR-HSA-1867974.532PDGFB, PTEN
DAP12 signalingR-HSA-24244914.642PDGFB, PTEN

NET-GE enrichment

Term New enriched termICP valueGenes
PI3K/AKT activation (R-HSA-198203) -6.320.01SMARCE1, PDGFB, PTEN
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530) NEW7.050.001SMARCE1, PDGFB, PTEN
PI3K events in ERBB2 signaling (R-HSA-1963642) -6.370.009SMARCE1, PDGFB, PTEN
Downstream signal transduction (R-HSA-186763) -4.650.019NF2, SMARCE1, PDGFB, PTEN
GAB1 signalosome (R-HSA-180292) -6.310.01SMARCE1, PDGFB, PTEN
Downstream signaling of activated FGFR1 (R-HSA-5654687) -4.710.016NF2, SMARCE1, PDGFB, PTEN
PIP3 activates AKT signaling (R-HSA-1257604) -6.370.009SMARCE1, PDGFB, PTEN
PI-3K cascade:FGFR4 (R-HSA-5654720) -6.370.009SMARCE1, PDGFB, PTEN
PI-3K cascade:FGFR1 (R-HSA-5654689) -6.370.009SMARCE1, PDGFB, PTEN
Downstream signaling of activated FGFR3 (R-HSA-5654708) -4.710.016SMARCE1, NF2, PDGFB, PTEN
Signaling by FGFR4 (R-HSA-5654743) -4.690.017NF2, SMARCE1, PDGFB, PTEN
Signaling by FGFR3 (R-HSA-5654741) -4.690.017NF2, SMARCE1, PDGFB, PTEN
Signaling by FGFR (R-HSA-190236) -4.670.017SMARCE1, NF2, PDGFB, PTEN
PI3K/AKT Signaling in Cancer (R-HSA-2219528) -6.560.005SMARCE1, PDGFB, PTEN
Innate Immune System (R-HSA-168249) -3.170.045NF2, SMARCE1, PDGFB, SUFU, PTEN
Signaling by PDGF (R-HSA-186797) -4.530.03SMARCE1, NF2, PDGFB, PTEN
DAP12 signaling (R-HSA-2424491) -4.640.018SMARCE1, NF2, PDGFB, PTEN
PI-3K cascade:FGFR2 (R-HSA-5654695) -6.370.009SMARCE1, PDGFB, PTEN
Downstream signaling of activated FGFR2 (R-HSA-5654696) -4.710.016NF2, SMARCE1, PDGFB, PTEN
Signaling by EGFR (R-HSA-177929) -4.590.02SMARCE1, NF2, PDGFB, PTEN
NGF signalling via TRKA from the plasma membrane (R-HSA-187037) -4.510.032SMARCE1, NF2, PDGFB, PTEN
Signaling by FGFR2 (R-HSA-5654738) -4.680.017SMARCE1, NF2, PDGFB, PTEN
Signaling by FGFR1 (R-HSA-5654736) -4.690.017SMARCE1, NF2, PDGFB, PTEN
PI3K events in ERBB4 signaling (R-HSA-1250342) -6.370.009SMARCE1, PDGFB, PTEN
PI-3K cascade:FGFR3 (R-HSA-5654710) -6.370.009SMARCE1, PDGFB, PTEN
DAP12 interactions (R-HSA-2172127) -4.560.023SMARCE1, NF2, PDGFB, PTEN
Downstream signaling of activated FGFR4 (R-HSA-5654716) -4.710.016NF2, SMARCE1, PDGFB, PTEN
Signaling by ERBB2 (R-HSA-1227986) -4.660.018SMARCE1, NF2, PDGFB, PTEN
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185NF2, SMARCE1, PDGFB, SUFU, PTEN
protein binding (GO:0005515) 0.465NF2, SMARCE1, PDGFB, SUFU, PTEN
protein complex binding (GO:0032403) 3.094SMARCE1, NF2, PDGFB, PTEN
receptor binding (GO:0005102) 2.434NF2, SMARCE1, PDGFB, PTEN
macromolecular complex binding (GO:0044877) 2.614SMARCE1, NF2, PDGFB, PTEN
catalytic activity (GO:0003824) 1.053SMARCE1, PDGFB, PTEN
enzyme binding (GO:0019899) 2.272SUFU, PTEN
growth factor receptor binding (GO:0070851) 4.872PDGFB, PTEN
platelet-derived growth factor receptor binding (GO:0005161) 7.12PDGFB, PTEN
transcription cofactor activity (GO:0003712) 3.442SMARCE1, SUFU
beta-catenin binding (GO:0008013) 5.32NF2, SUFU
protein kinase binding (GO:0019901) 3.442SUFU, PTEN
kinase binding (GO:0019900) 3.322SUFU, PTEN
transferase activity (GO:0016740) 1.952SMARCE1, PDGFB
protein domain specific binding (GO:0019904) 3.322NF2, PTEN
transcription factor activity, transcription factor binding (GO:0000989) 3.362SMARCE1, SUFU
transcription factor activity, protein binding (GO:0000988) 3.352SMARCE1, SUFU
identical protein binding (GO:0042802) 2.632PDGFB, PTEN

NET-GE enrichment

Term New enriched termICP valueGenes
growth factor activity (GO:0008083) NEW4.660.045SMARCE1, PDGFB, PTEN
growth factor receptor binding (GO:0070851) -4.870.046PDGFB, PTEN
platelet-derived growth factor receptor binding (GO:0005161) -7.10.003PDGFB, PTEN
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.366NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
cellular process (GO:0009987) 0.266NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of primary metabolic process (GO:0080090) 1.086NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of metabolic process (GO:0019222) 1.026NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.436NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.466NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of cellular metabolic process (GO:0031323) 1.076NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
anatomical structure development (GO:0048856) 1.586NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of biosynthetic process (GO:0009889) 1.376NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of cellular process (GO:0050794) 0.56NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of macromolecule metabolic process (GO:0060255) 1.086NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of macromolecule biosynthetic process (GO:0010556) 1.436NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
biological regulation (GO:0065007) 0.396NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of nitrogen compound metabolic process (GO:0051171) 1.366NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of cellular biosynthetic process (GO:0031326) 1.386NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
regulation of biological process (GO:0050789) 0.456NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
single-organism process (GO:0044699) 0.486NF2, MN1, SUFU, SMARCE1, PTEN, PDGFB
negative regulation of cellular metabolic process (GO:0031324) 2.015NF2, SMARCE1, PDGFB, SUFU, PTEN
negative regulation of metabolic process (GO:0009892) 1.935SMARCE1, NF2, PDGFB, SUFU, PTEN
regulation of RNA metabolic process (GO:0051252) 1.525MN1, SMARCE1, PDGFB, SUFU, PTEN
regulation of nucleic acid-templated transcription (GO:1903506) 1.555MN1, SMARCE1, PDGFB, SUFU, PTEN
negative regulation of macromolecule metabolic process (GO:0010605) 2.015SMARCE1, NF2, PDGFB, SUFU, PTEN
single-organism developmental process (GO:0044767) 1.495NF2, MN1, PDGFB, SUFU, PTEN
regulation of transcription, DNA-templated (GO:0006355) 1.565SMARCE1, MN1, PDGFB, SUFU, PTEN
single-organism cellular process (GO:0044763) 0.655SMARCE1, NF2, PDGFB, SUFU, PTEN
regulation of RNA biosynthetic process (GO:2001141) 1.555MN1, SMARCE1, PDGFB, SUFU, PTEN
negative regulation of biological process (GO:0048519) 1.335SMARCE1, NF2, PDGFB, SUFU, PTEN
regulation of gene expression (GO:0010468) 1.375MN1, SMARCE1, PDGFB, SUFU, PTEN
negative regulation of cellular process (GO:0048523) 1.415SMARCE1, NF2, PDGFB, SUFU, PTEN
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.474SMARCE1, NF2, PDGFB, SUFU
negative regulation of biosynthetic process (GO:0009890) 2.474NF2, SMARCE1, PDGFB, SUFU
negative regulation of cellular biosynthetic process (GO:0031327) 2.494NF2, SMARCE1, PDGFB, SUFU
negative regulation of response to stimulus (GO:0048585) 2.524NF2, PDGFB, SUFU, PTEN
regulation of response to stimulus (GO:0048583) 1.544NF2, PDGFB, SUFU, PTEN
metabolic process (GO:0008152) 0.584MN1, PDGFB, SUFU, PTEN
regulation of signaling (GO:0023051) 1.724NF2, PDGFB, SUFU, PTEN
regulation of cell communication (GO:0010646) 1.734NF2, PDGFB, SUFU, PTEN
cellular component organization or biogenesis (GO:0071840) 1.224NF2, SMARCE1, PDGFB, PTEN
regulation of signal transduction (GO:0009966) 1.844NF2, PDGFB, SUFU, PTEN
cellular developmental process (GO:0048869) 1.824NF2, SMARCE1, PDGFB, PTEN
regulation of protein metabolic process (GO:0051246) 1.934NF2, PDGFB, SUFU, PTEN
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.64SMARCE1, NF2, PDGFB, SUFU
cellular component organization (GO:0016043) 1.244NF2, SMARCE1, PDGFB, PTEN
organic substance metabolic process (GO:0071704) 0.634MN1, PDGFB, SUFU, PTEN
animal organ development (GO:0048513) 2.534NF2, PDGFB, SUFU, PTEN
regulation of protein modification process (GO:0031399) 2.324NF2, PDGFB, SUFU, PTEN
regulation of molecular function (GO:0065009) 1.784NF2, PDGFB, SUFU, PTEN
regulation of biological quality (GO:0065008) 1.684NF2, PDGFB, SUFU, PTEN
multicellular organismal process (GO:0032501) 1.454MN1, PDGFB, SUFU, PTEN
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.554SMARCE1, NF2, PDGFB, SUFU
regulation of developmental process (GO:0050793) 2.14NF2, PDGFB, SUFU, PTEN
negative regulation of molecular function (GO:0044092) 2.744NF2, PDGFB, SUFU, PTEN
regulation of cell differentiation (GO:0045595) 2.424NF2, PDGFB, SUFU, PTEN
regulation of multicellular organismal process (GO:0051239) 1.874NF2, PDGFB, SUFU, PTEN
regulation of localization (GO:0032879) 1.944NF2, PDGFB, SUFU, PTEN
primary metabolic process (GO:0044238) 0.694MN1, PDGFB, SUFU, PTEN
regulation of cellular protein metabolic process (GO:0032268) 1.994NF2, PDGFB, SUFU, PTEN
single-multicellular organism process (GO:0044707) 1.784MN1, PDGFB, SUFU, PTEN
macromolecule metabolic process (GO:0043170) 0.834MN1, PDGFB, SUFU, PTEN
regulation of multicellular organismal development (GO:2000026) 2.314NF2, PDGFB, SUFU, PTEN
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.534SMARCE1, NF2, PDGFB, SUFU
negative regulation of multicellular organismal process (GO:0051241) 2.843PDGFB, SUFU, PTEN
regulation of phosphate metabolic process (GO:0019220) 2.353NF2, PDGFB, PTEN
regulation of cellular localization (GO:0060341) 3.033NF2, SUFU, PTEN
regulation of transport (GO:0051049) 2.243PDGFB, SUFU, PTEN
regulation of cellular component organization (GO:0051128) 2.013NF2, PDGFB, PTEN
negative regulation of signaling (GO:0023057) 2.653NF2, SUFU, PTEN
negative regulation of gene expression (GO:0010629) 2.483SMARCE1, PDGFB, SUFU
regulation of cell migration (GO:0030334) 3.233NF2, PDGFB, PTEN
signal transduction (GO:0007165) 1.283PDGFB, SUFU, PTEN
cell surface receptor signaling pathway (GO:0007166) 2.093PDGFB, SUFU, PTEN
anatomical structure morphogenesis (GO:0009653) 2.533NF2, SUFU, PTEN
multicellular organism development (GO:0007275) 2.543MN1, PDGFB, SUFU
regulation of MAPK cascade (GO:0043408) 3.223NF2, PDGFB, PTEN
negative regulation of cell communication (GO:0010648) 2.663NF2, SUFU, PTEN
organic substance biosynthetic process (GO:1901576) 1.343MN1, PDGFB, PTEN
negative regulation of protein metabolic process (GO:0051248) 2.823NF2, SUFU, PTEN
cellular macromolecule metabolic process (GO:0044260) 0.933MN1, PDGFB, PTEN
negative regulation of phosphorus metabolic process (GO:0010563) 3.453NF2, PDGFB, PTEN
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243SMARCE1, PDGFB, SUFU
regulation of kinase activity (GO:0043549) 3.073NF2, PDGFB, PTEN
positive regulation of biological process (GO:0048518) 1.23NF2, PDGFB, PTEN
anatomical structure formation involved in morphogenesis (GO:0048646) 3.013NF2, SUFU, PTEN
regulation of cell proliferation (GO:0042127) 2.413NF2, PDGFB, PTEN
negative regulation of developmental process (GO:0051093) 3.173PDGFB, SUFU, PTEN
regulation of catalytic activity (GO:0050790) 1.973NF2, PDGFB, PTEN
negative regulation of phosphate metabolic process (GO:0045936) 3.453NF2, PDGFB, PTEN
regulation of protein kinase activity (GO:0045859) 3.153NF2, PDGFB, PTEN
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.713SMARCE1, PDGFB, SUFU
negative regulation of RNA biosynthetic process (GO:1902679) 2.73SMARCE1, PDGFB, SUFU
negative regulation of cell differentiation (GO:0045596) 3.333PDGFB, SUFU, PTEN
biosynthetic process (GO:0009058) 1.323MN1, PDGFB, PTEN
regulation of cellular component movement (GO:0051270) 3.083NF2, PDGFB, PTEN
negative regulation of transcription, DNA-templated (GO:0045892) 2.753SMARCE1, PDGFB, SUFU
regulation of intracellular signal transduction (GO:1902531) 2.313NF2, PDGFB, PTEN
regulation of phosphorylation (GO:0042325) 2.53NF2, PDGFB, PTEN
regulation of phosphorus metabolic process (GO:0051174) 2.353NF2, PDGFB, PTEN
negative regulation of cellular protein metabolic process (GO:0032269) 2.883NF2, SUFU, PTEN
regulation of locomotion (GO:0040012) 3.123NF2, PDGFB, PTEN
negative regulation of signal transduction (GO:0009968) 2.753NF2, SUFU, PTEN
cellular biosynthetic process (GO:0044249) 1.373MN1, PDGFB, PTEN
protein metabolic process (GO:0019538) 1.453PDGFB, SUFU, PTEN
negative regulation of RNA metabolic process (GO:0051253) 2.663SMARCE1, PDGFB, SUFU
regulation of transferase activity (GO:0051338) 2.883NF2, PDGFB, PTEN
regulation of nervous system development (GO:0051960) 3.13NF2, SUFU, PTEN
regulation of cell motility (GO:2000145) 3.163NF2, PDGFB, PTEN
system development (GO:0048731) 2.923SMARCE1, SUFU, PTEN
cellular metabolic process (GO:0044237) 0.693MN1, PDGFB, PTEN
regulation of protein phosphorylation (GO:0001932) 2.573NF2, PDGFB, PTEN
negative regulation of protein modification process (GO:0031400) 3.43NF2, SUFU, PTEN
positive regulation of cellular process (GO:0048522) 1.33NF2, PDGFB, PTEN
positive regulation of response to stimulus (GO:0048584) 2.182PDGFB, PTEN
negative regulation of cell adhesion (GO:0007162) 4.332NF2, PTEN
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242PDGFB, PTEN
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542PDGFB, PTEN
organic cyclic compound metabolic process (GO:1901360) 1.262MN1, PDGFB
single-organism metabolic process (GO:0044710) 1.632PDGFB, PTEN
positive regulation of macromolecule metabolic process (GO:0010604) 1.812PDGFB, PTEN
positive regulation of signal transduction (GO:0009967) 2.52PDGFB, PTEN
regulation of organelle organization (GO:0033043) 2.722NF2, PDGFB
positive regulation of molecular function (GO:0044093) 2.232PDGFB, PTEN
heterocycle metabolic process (GO:0046483) 1.312MN1, PDGFB
regulation of DNA metabolic process (GO:0051052) 3.872NF2, PDGFB
negative regulation of transport (GO:0051051) 3.62SUFU, PTEN
developmental process involved in reproduction (GO:0003006) 3.362PDGFB, PTEN
single organism reproductive process (GO:0044702) 2.732PDGFB, PTEN
phosphatidylinositol metabolic process (GO:0046488) 4.462PDGFB, PTEN
glycerolipid metabolic process (GO:0046486) 3.912PDGFB, PTEN
response to organic substance (GO:0010033) 2.22PDGFB, PTEN
system process (GO:0003008) 2.32PDGFB, PTEN
single organism signaling (GO:0044700) 3.252PDGFB, PTEN
positive regulation of phosphorylation (GO:0042327) 2.92PDGFB, PTEN
negative regulation of phosphorylation (GO:0042326) 3.72NF2, PTEN
cell motility (GO:0048870) 3.022PDGFB, PTEN
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.352NF2, PDGFB
response to organonitrogen compound (GO:0010243) 3.22PDGFB, PTEN
positive regulation of organelle organization (GO:0010638) 3.382NF2, PDGFB
cellular nitrogen compound metabolic process (GO:0034641) 1.222MN1, PDGFB
regulation of DNA replication (GO:0006275) 5.022NF2, PDGFB
immune system process (GO:0002376) 2.292PDGFB, PTEN
organophosphate metabolic process (GO:0019637) 3.042PDGFB, PTEN
regulation of cyclin-dependent protein kinase activity (GO:1904029) 5.212PDGFB, PTEN
negative regulation of kinase activity (GO:0033673) 4.222NF2, PTEN
regulation of catabolic process (GO:0009894) 3.522SUFU, PTEN
positive regulation of metabolic process (GO:0009893) 1.742PDGFB, PTEN
regulation of protein stability (GO:0031647) 4.332NF2, PTEN
negative regulation of cell-matrix adhesion (GO:0001953) 6.292NF2, PTEN
movement of cell or subcellular component (GO:0006928) 2.612PDGFB, PTEN
regulation of response to stress (GO:0080134) 2.532PDGFB, PTEN
platelet-derived growth factor receptor signaling pathway (GO:0048008) 6.152PDGFB, PTEN
nitrogen compound metabolic process (GO:0006807) 1.132MN1, PDGFB
intracellular signal transduction (GO:0035556) 2.392PDGFB, PTEN
regulation of protein serine/threonine kinase activity (GO:0071900) 3.582PDGFB, PTEN
cellular protein metabolic process (GO:0044267) 1.632PDGFB, PTEN
regulation of mitotic cell cycle (GO:0007346) 3.712PDGFB, PTEN
positive regulation of transferase activity (GO:0051347) 3.312PDGFB, PTEN
regulation of cellular protein catabolic process (GO:1903362) 4.232SUFU, PTEN
negative regulation of transferase activity (GO:0051348) 3.872NF2, PTEN
negative regulation of MAPK cascade (GO:0043409) 4.742NF2, PTEN
cell migration (GO:0016477) 3.122PDGFB, PTEN
positive regulation of cellular component organization (GO:0051130) 2.682NF2, PDGFB
organ morphogenesis (GO:0009887) 3.552NF2, PTEN
lipid metabolic process (GO:0006629) 2.682PDGFB, PTEN
nucleobase-containing compound metabolic process (GO:0006139) 1.352MN1, PDGFB
cellular response to stimulus (GO:0051716) 1.972PDGFB, PTEN
tissue development (GO:0009888) 3.272NF2, PTEN
positive regulation of MAPK cascade (GO:0043410) 3.572PDGFB, PTEN
macromolecule modification (GO:0043412) 1.732PDGFB, PTEN
protein modification process (GO:0036211) 1.792PDGFB, PTEN
negative regulation of intracellular signal transduction (GO:1902532) 3.632NF2, PTEN
positive regulation of intracellular signal transduction (GO:1902533) 2.952PDGFB, PTEN
phosphatidylinositol-mediated signaling (GO:0048015) 4.932PDGFB, PTEN
inositol lipid-mediated signaling (GO:0048017) 4.912PDGFB, PTEN
regulation of protein localization to nucleus (GO:1900180) 4.342NF2, SUFU
response to decreased oxygen levels (GO:0036293) 4.092PDGFB, PTEN
response to stimulus (GO:0050896) 1.222PDGFB, PTEN
positive regulation of protein modification process (GO:0031401) 2.72PDGFB, PTEN
response to stress (GO:0006950) 1.82PDGFB, PTEN
negative regulation of nervous system development (GO:0051961) 4.152SUFU, PTEN
negative regulation of cell motility (GO:2000146) 4.362NF2, PTEN
negative regulation of response to external stimulus (GO:0032102) 4.182PDGFB, PTEN
regulation of response to external stimulus (GO:0032101) 3.062PDGFB, PTEN
regulation of cell adhesion (GO:0030155) 3.272NF2, PTEN
cell differentiation (GO:0030154) 2.142SMARCE1, NF2
regulation of cellular protein localization (GO:1903827) 3.432NF2, SUFU
regulation of protein catabolic process (GO:0042176) 3.832SUFU, PTEN
signaling (GO:0023052) 3.252PDGFB, PTEN
cellular response to chemical stimulus (GO:0070887) 2.572PDGFB, PTEN
cell communication (GO:0007154) 3.042PDGFB, PTEN
positive regulation of cell communication (GO:0010647) 2.412PDGFB, PTEN
response to hypoxia (GO:0001666) 4.132PDGFB, PTEN
negative regulation of catalytic activity (GO:0043086) 3.02NF2, PTEN
response to organic cyclic compound (GO:0014070) 3.072PDGFB, PTEN
regulation of protein localization (GO:0032880) 2.882NF2, SUFU
response to endogenous stimulus (GO:0009719) 2.792PDGFB, PTEN
regulation of neurogenesis (GO:0050767) 3.212NF2, PTEN
regulation of system process (GO:0044057) 3.532PDGFB, PTEN
response to nitrogen compound (GO:1901698) 3.122PDGFB, PTEN
positive regulation of phosphorus metabolic process (GO:0010562) 2.782PDGFB, PTEN
regulation of cell cycle process (GO:0010564) 3.52PDGFB, PTEN
positive regulation of protein metabolic process (GO:0051247) 2.432PDGFB, PTEN
regulation of cell development (GO:0060284) 3.012NF2, PTEN
regulation of protein modification by small protein conjugation or removal (GO:1903320) 4.142SUFU, PTEN
positive regulation of cellular protein metabolic process (GO:0032270) 2.492PDGFB, PTEN
regulation of protein ubiquitination (GO:0031396) 4.222SUFU, PTEN
regulation of response to wounding (GO:1903034) 4.742PDGFB, PTEN
positive regulation of catalytic activity (GO:0043085) 2.42PDGFB, PTEN
positive regulation of cell proliferation (GO:0008284) 3.012PDGFB, PTEN
negative regulation of cell proliferation (GO:0008285) 3.262NF2, PTEN
phospholipid metabolic process (GO:0006644) 3.882PDGFB, PTEN
positive regulation of signaling (GO:0023056) 2.412PDGFB, PTEN
cell proliferation (GO:0008283) 3.232NF2, PTEN
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050) 4.322SUFU, PTEN
cellular aromatic compound metabolic process (GO:0006725) 1.32MN1, PDGFB
negative regulation of cellular component movement (GO:0051271) 4.222NF2, PTEN
cellular macromolecule biosynthetic process (GO:0034645) 1.662MN1, PDGFB
locomotion (GO:0040011) 2.912PDGFB, PTEN
cellular lipid metabolic process (GO:0044255) 2.922PDGFB, PTEN
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.792PDGFB, PTEN
lipid modification (GO:0030258) 4.372PDGFB, PTEN
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832SUFU, PTEN
regulation of epithelial cell proliferation (GO:0050678) 4.062PDGFB, PTEN
response to drug (GO:0042493) 3.712PDGFB, PTEN
regulation of cell-matrix adhesion (GO:0001952) 5.212NF2, PTEN
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562PDGFB, PTEN
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232PDGFB, PTEN
heart development (GO:0007507) 4.242PDGFB, PTEN
negative regulation of growth (GO:0045926) 4.242NF2, PTEN
glycerophospholipid metabolic process (GO:0006650) 4.132PDGFB, PTEN
regulation of cellular catabolic process (GO:0031329) 3.832SUFU, PTEN
positive regulation of cellular metabolic process (GO:0031325) 1.812PDGFB, PTEN
nucleic acid metabolic process (GO:0090304) 1.462MN1, PDGFB
response to estradiol (GO:0032355) 4.732PDGFB, PTEN
growth (GO:0040007) 3.82PDGFB, PTEN
response to lipid (GO:0033993) 3.112PDGFB, PTEN
regulation of growth (GO:0040008) 3.262NF2, PTEN
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2000058) 5.122SUFU, PTEN
negative regulation of cell migration (GO:0030336) 4.412NF2, PTEN
negative regulation of protein kinase activity (GO:0006469) 4.292NF2, PTEN
positive regulation of phosphate metabolic process (GO:0045937) 2.782PDGFB, PTEN
regulation of cell-substrate adhesion (GO:0010810) 4.562NF2, PTEN
negative regulation of cell-substrate adhesion (GO:0010812) 5.762NF2, PTEN
cellular protein modification process (GO:0006464) 1.792PDGFB, PTEN
reproductive process (GO:0022414) 2.552PDGFB, PTEN
macromolecule biosynthetic process (GO:0009059) 1.612MN1, PDGFB
cell-cell signaling (GO:0007267) 3.352PDGFB, PTEN
response to chemical (GO:0042221) 1.982PDGFB, PTEN
localization (GO:0051179) 1.42PDGFB, SUFU
single-organism localization (GO:1902578) 2.092PDGFB, SUFU
response to oxygen levels (GO:0070482) 4.022PDGFB, PTEN
response to oxygen-containing compound (GO:1901700) 2.572PDGFB, PTEN
response to abiotic stimulus (GO:0009628) 2.82PDGFB, PTEN
negative regulation of locomotion (GO:0040013) 4.222NF2, PTEN
organelle organization (GO:0006996) 2.022NF2, PTEN
nervous system development (GO:0007399) 3.532SMARCE1, PTEN
regulation of cell cycle (GO:0051726) 2.932PDGFB, PTEN
regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079) 5.262PDGFB, PTEN
regulation of cellular component biogenesis (GO:0044087) 3.082NF2, PTEN
phosphate-containing compound metabolic process (GO:0006796) 2.162PDGFB, PTEN
phosphorus metabolic process (GO:0006793) 2.152PDGFB, PTEN
regulation of proteolysis (GO:0030162) 3.22SUFU, PTEN
negative regulation of protein phosphorylation (GO:0001933) 3.792NF2, PTEN
positive regulation of protein phosphorylation (GO:0001934) 2.952PDGFB, PTEN

NET-GE enrichment

Term New enriched termICP valueGenes
cell proliferation involved in kidney development (GO:0072111) NEW7.430.026PDGFB, PTEN
negative regulation of cell migration (GO:0030336) -4.410.011NF2, PDGFB, PTEN
negative regulation of cellular component movement (GO:0051271) -4.220.013NF2, PDGFB, PTEN
negative regulation of macromolecule metabolic process (GO:0010605) -2.010.024NF2, SMARCE1, PDGFB, SUFU, PTEN
bone trabecula formation (GO:0060346) NEW7.650.029PDGFB, PTEN
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) -4.350.028SMARCE1, NF2, PDGFB, PTEN
negative regulation of cellular metabolic process (GO:0031324) -2.010.026NF2, SMARCE1, PDGFB, SUFU, PTEN
negative regulation of cell-matrix adhesion (GO:0001953) -6.290.022NF2, PTEN
negative regulation of locomotion (GO:0040013) -4.220.02NF2, PDGFB, PTEN
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2000058) -5.120.011SUFU, PTEN
platelet-derived growth factor receptor signaling pathway (GO:0048008) -6.150.032PDGFB, PTEN
epidermal growth factor receptor signaling pathway (GO:0007173) NEW5.720.008NF2, SMARCE1, PDGFB, PTEN
ERBB signaling pathway (GO:0038127) NEW5.360.009SMARCE1, NF2, PDGFB, PTEN
negative regulation of cell motility (GO:2000146) -4.360.012NF2, PDGFB, PTEN
negative regulation of metabolic process (GO:0009892) -1.930.038NF2, SMARCE1, PDGFB, SUFU, PTEN
skin development (GO:0043588) NEW5.840.004PDGFB, SUFU, PTEN
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.285NF2, SMARCE1, PDGFB, SUFU, PTEN
intracellular organelle part (GO:0044446) 0.815NF2, SMARCE1, PDGFB, SUFU, PTEN
cell part (GO:0044464) 0.115SMARCE1, NF2, PDGFB, SUFU, PTEN
organelle part (GO:0044422) 0.795NF2, SMARCE1, PDGFB, SUFU, PTEN
cytoplasm (GO:0005737) 1.014NF2, PDGFB, SUFU, PTEN
intracellular membrane-bounded organelle (GO:0043231) 0.64NF2, SMARCE1, SUFU, PTEN
nucleus (GO:0005634) 1.074NF2, SMARCE1, SUFU, PTEN
cytoplasmic part (GO:0044444) 0.824NF2, PDGFB, SUFU, PTEN
intracellular organelle (GO:0043229) 0.514NF2, SMARCE1, SUFU, PTEN
nuclear part (GO:0044428) 1.554NF2, SMARCE1, SUFU, PTEN
membrane-bounded organelle (GO:0043227) 0.474SMARCE1, NF2, SUFU, PTEN
organelle (GO:0043226) 0.44SMARCE1, NF2, SUFU, PTEN
plasma membrane region (GO:0098590) 2.973NF2, PDGFB, PTEN
cell projection part (GO:0044463) 2.973NF2, SUFU, PTEN
membrane (GO:0016020) 0.683NF2, PDGFB, PTEN
nucleoplasm (GO:0005654) 1.893SMARCE1, SUFU, PTEN
neuron part (GO:0097458) 2.643NF2, SMARCE1, PTEN
membrane part (GO:0044425) 0.953NF2, PDGFB, PTEN
cell projection (GO:0042995) 2.473NF2, SUFU, PTEN
plasma membrane part (GO:0044459) 1.953NF2, PDGFB, PTEN
protein complex (GO:0043234) 1.512SMARCE1, NF2
macromolecular complex (GO:0032991) 1.352SMARCE1, NF2
intracellular non-membrane-bounded organelle (GO:0043232) 1.762SMARCE1, NF2
cytosol (GO:0005829) 1.682SUFU, PTEN
non-membrane-bounded organelle (GO:0043228) 1.762NF2, SMARCE1
neuron projection (GO:0043005) 3.122NF2, PTEN
plasma membrane (GO:0005886) 1.392NF2, PTEN
extracellular region (GO:0005576) 2.182PDGFB, PTEN

NET-GE enrichment

Term New enriched termICP valueGenes
extracellular space (GO:0005615) NEW2.630.043NF2, SMARCE1, PDGFB, SUFU, PTEN
endoplasmic reticulum lumen (GO:0005788) NEW4.50.034PDGFB, SUFU, PTEN