Disease table of PITUITARY HORMONE DEFICIENCY, COMBINED OMIM ID: PS613038

Gene-disease associations table

Gene	Associated with PITUITARY HORMONE DEFICIENCY, COMBINED in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
POU1F1	ClinVar, OMIM, HUMSAVAR	HGNC link	3p11.2	1	PS613038
LHX3	ClinVar, OMIM, HUMSAVAR	HGNC link	9q34.3	1	PS613038
LHX4	ClinVar, OMIM, HUMSAVAR	HGNC link	1q25.2	1	PS613038
HESX1	OMIM, HUMSAVAR	HGNC link	3p14.3	1	PS613038
OTX2	ClinVar, OMIM, HUMSAVAR	HGNC link	14q22.3	2	PS309800, PS613038
PROP1	ClinVar, OMIM, HUMSAVAR	HGNC link	5q35.3	1	PS613038

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
3p1	2	POU1F1, HESX1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
3p	2	POU1F1, HESX1

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
3	2	POU1F1, HESX1

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
POU1F1	YES	11	BDKRB1, GHR, VDR, INSM1, TSHB, PRL, GH1, REN, GH2, POU1F1, CGA	1	POU1F1
LHX3	YES	1	FSHB	0
LHX4	YES	1	POU1F1	1	POU1F1
OTX2	YES	12	TYR, POU1F1, HESX1, DCT, BEST1, AURKA, RBP3, IL6, CCNG2, IGF1, PAX6, CDC25C	2	HESX1, POU1F1
SOX2	NO	24	POU4F2, ISL1, NTRK3, FGF4, VIM, TUBB3, LHX3, ITGA6, CCND1, L1TD1, PGA5, DKK1, PAX6, MKI67, RHO, ABCC6, PLAC1, UTF1, ABCC3, POU1F1, LXN, MMP3, SEMA6A, ASXL1	2	LHX3, POU1F1

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
POU1F1	YES	7	OTX2, SOX2, HMGA1, LHX4, POU1F1, HMGA2, LHX2	3	OTX2, LHX4, POU1F1
LHX3	YES	1	SOX2	0
HESX1	YES	3	OTX2, GATA4, PITX2	1	OTX2

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
POU1F1	HESX1	No	1	NCOR1
LHX3	LHX4	No	3	ISL2, IFT172, ISL1
LHX3	OTX2	No	1	LHX1
HESX1	PROP1	No	1	TLE1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
POU1F1	HESX1	No	-	1	NCOR1
POU1F1	PROP1	Yes	activation, binding	0
LHX3	LHX4	No	-	3	SP1, IFT172, ISL1
HESX1	OTX2	No	-	1	FGF8
HESX1	PROP1	No	-	1	TLE1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Signaling pathways regulating pluripotency of stem cells (hsa04550)	NEW	5.6	0.015	LHX3, OTX2, HESX1

REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
sequence-specific DNA binding (GO:0043565)	2.79	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
protein binding (GO:0005515)	0.46	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
organic cyclic compound binding (GO:0097159)	1.05	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
binding (GO:0005488)	0.18	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
nucleic acid binding (GO:0003676)	1.44	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
DNA binding (GO:0003677)	1.92	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
heterocyclic compound binding (GO:1901363)	1.06	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
transcription regulatory region DNA binding (GO:0044212)	3.03	3	PROP1, OTX2, POU1F1
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	3	PROP1, OTX2, POU1F1
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	3	PROP1, OTX2, POU1F1
RNA polymerase II regulatory region DNA binding (GO:0001012)	3.36	3	PROP1, OTX2, POU1F1
regulatory region nucleic acid binding (GO:0001067)	3.03	3	PROP1, OTX2, POU1F1
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	3.98	3	PROP1, OTX2, POU1F1
macromolecular complex binding (GO:0044877)	2.61	3	PROP1, POU1F1, HESX1
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	3.37	3	PROP1, OTX2, POU1F1
regulatory region DNA binding (GO:0000975)	3.03	3	PROP1, OTX2, POU1F1
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	3	PROP1, OTX2, POU1F1
double-stranded DNA binding (GO:0003690)	3.09	3	PROP1, OTX2, POU1F1
chromatin binding (GO:0003682)	3.64	3	PROP1, HESX1, POU1F1
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	3	PROP1, OTX2, POU1F1
nucleic acid binding transcription factor activity (GO:0001071)	2.65	3	PROP1, OTX2, POU1F1
RNA polymerase II transcription factor binding (GO:0001085)	5.08	2	LHX3, POU1F1
cation binding (GO:0043169)	1.4	2	LHX3, LHX4
protein C-terminus binding (GO:0008022)	4.5	2	PROP1, HESX1
transition metal ion binding (GO:0046914)	2.48	2	LHX3, LHX4
transcription factor binding (GO:0008134)	3.46	2	LHX3, POU1F1
core promoter proximal region DNA binding (GO:0001159)	3.82	2	OTX2, POU1F1
ion binding (GO:0043167)	1.36	2	LHX3, LHX4
transcription factor activity, RNA polymerase II transcription factor binding (GO:0001076)	4.84	2	LHX3, POU1F1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077)	4.31	2	OTX2, POU1F1
zinc ion binding (GO:0008270)	2.66	2	LHX3, LHX4
transcription factor activity, transcription factor binding (GO:0000989)	3.36	2	LHX3, POU1F1
transcription factor activity, protein binding (GO:0000988)	3.35	2	LHX3, POU1F1
core promoter proximal region sequence-specific DNA binding (GO:0000987)	3.83	2	OTX2, POU1F1
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	3.88	2	OTX2, POU1F1
metal ion binding (GO:0046872)	1.41	2	LHX3, LHX4
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982)	3.94	2	OTX2, POU1F1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
transcription regulatory region DNA binding (GO:0044212)	-	3.03	0.044	LHX3, OTX2, POU1F1, HESX1
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription (GO:0001190)	NEW	5.77	0.036	LHX3, POU1F1
nucleic acid binding transcription factor activity (GO:0001071)	-	2.65	0.043	LHX3, PROP1, HESX1, POU1F1, OTX2
nucleic acid binding (GO:0003676)	-	1.44	0.009	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
sequence-specific DNA binding (GO:0043565)	-	2.79	0.0	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
sequence-specific DNA binding transcription factor activity (GO:0003700)	-	2.65	0.042	LHX3, PROP1, HESX1, POU1F1, OTX2
RNA polymerase II regulatory region DNA binding (GO:0001012)	-	3.36	0.007	LHX3, OTX2, HESX1, POU1F1
transcription corepressor activity (GO:0003714)	NEW	4.33	0.002	LHX3, OTX2, LHX4, POU1F1
regulatory region nucleic acid binding (GO:0001067)	-	3.03	0.046	LHX3, OTX2, POU1F1, HESX1
protein binding transcription factor activity (GO:0000988)	-	3.35	0.003	LHX3, LHX4, OTX2, POU1F1, HESX1
transcription factor binding transcription factor activity (GO:0000989)	-	3.36	0.003	LHX3, LHX4, OTX2, POU1F1, HESX1
RNA polymerase II transcription coactivator activity (GO:0001105)	NEW	6.15	0.012	LHX3, POU1F1
RNA polymerase II transcription factor binding transcription factor activity (GO:0001076)	-	4.84	0.028	LHX3, OTX2, HESX1, POU1F1
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077)	-	4.31	0.031	LHX3, OTX2, POU1F1
transcription regulatory region sequence-specific DNA binding (GO:0000976)	-	3.24	0.012	LHX3, OTX2, POU1F1, HESX1
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	-	3.37	0.007	LHX3, OTX2, POU1F1, HESX1
RNA polymerase II activating transcription factor binding (GO:0001102)	NEW	6.13	0.029	LHX3, POU1F1
DNA binding (GO:0003677)	-	1.92	0.0	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
chromatin binding (GO:0003682)	-	3.64	0.001	LHX3, PROP1, HESX1, POU1F1, OTX2
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981)	-	3.29	0.022	LHX3, OTX2, HESX1, POU1F1
regulatory region DNA binding (GO:0000975)	-	3.03	0.046	LHX3, OTX2, HESX1, POU1F1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
anatomical structure development (GO:0048856)	1.58	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of primary metabolic process (GO:0080090)	1.08	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of metabolic process (GO:0019222)	1.02	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of cellular biosynthetic process (GO:0031326)	1.38	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of cellular metabolic process (GO:0031323)	1.07	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
nucleic acid metabolic process (GO:0090304)	1.46	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
cellular biosynthetic process (GO:0044249)	1.37	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
cellular nitrogen compound metabolic process (GO:0034641)	1.22	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
nitrogen compound metabolic process (GO:0006807)	1.13	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
cellular macromolecule biosynthetic process (GO:0034645)	1.66	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
organic cyclic compound biosynthetic process (GO:1901362)	1.66	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of biological process (GO:0050789)	0.45	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
nucleic acid-templated transcription (GO:0097659)	1.91	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
RNA biosynthetic process (GO:0032774)	1.84	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
organic substance biosynthetic process (GO:1901576)	1.34	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
cellular macromolecule metabolic process (GO:0044260)	0.93	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
organic substance metabolic process (GO:0071704)	0.63	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
biological regulation (GO:0065007)	0.39	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
organic cyclic compound metabolic process (GO:1901360)	1.26	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of gene expression (GO:0010468)	1.37	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
heterocycle biosynthetic process (GO:0018130)	1.7	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
developmental process (GO:0032502)	1.36	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of macromolecule metabolic process (GO:0060255)	1.08	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
cellular aromatic compound metabolic process (GO:0006725)	1.3	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
cellular process (GO:0009987)	0.26	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of biosynthetic process (GO:0009889)	1.37	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of cellular process (GO:0050794)	0.5	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
single-organism developmental process (GO:0044767)	1.49	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
biosynthetic process (GO:0009058)	1.32	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
macromolecule biosynthetic process (GO:0009059)	1.61	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
metabolic process (GO:0008152)	0.58	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of RNA biosynthetic process (GO:2001141)	1.55	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
heterocycle metabolic process (GO:0046483)	1.31	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
RNA metabolic process (GO:0016070)	1.59	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
primary metabolic process (GO:0044238)	0.69	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
single-organism process (GO:0044699)	0.48	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of RNA metabolic process (GO:0051252)	1.52	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
cellular metabolic process (GO:0044237)	0.69	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
macromolecule metabolic process (GO:0043170)	0.83	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of transcription, DNA-templated (GO:0006355)	1.56	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
transcription, DNA-templated (GO:0006351)	1.91	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
aromatic compound biosynthetic process (GO:0019438)	1.7	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
multicellular organismal process (GO:0032501)	1.45	5	LHX3, PROP1, HESX1, POU1F1, OTX2
single-multicellular organism process (GO:0044707)	1.78	5	LHX3, PROP1, POU1F1, HESX1, OTX2
cellular developmental process (GO:0048869)	1.82	5	LHX3, PROP1, LHX4, POU1F1, OTX2
cell differentiation (GO:0030154)	2.14	5	LHX3, PROP1, LHX4, POU1F1, OTX2
animal organ development (GO:0048513)	2.53	5	LHX3, LHX4, PROP1, HESX1, POU1F1
single-organism cellular process (GO:0044763)	0.65	5	LHX3, PROP1, LHX4, POU1F1, OTX2
negative regulation of biological process (GO:0048519)	1.33	5	LHX3, LHX4, PROP1, POU1F1, HESX1
negative regulation of cellular process (GO:0048523)	1.41	5	LHX3, LHX4, PROP1, HESX1, POU1F1
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of cellular process (GO:0048522)	1.3	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of biosynthetic process (GO:0009891)	2.29	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of cellular metabolic process (GO:0031325)	1.81	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of RNA metabolic process (GO:0051254)	2.51	4	LHX3, PROP1, OTX2, POU1F1
movement of cell or subcellular component (GO:0006928)	2.61	4	LHX3, PROP1, OTX2, LHX4
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of gene expression (GO:0010628)	2.35	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	4	LHX3, PROP1, OTX2, POU1F1
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	4	LHX3, PROP1, OTX2, POU1F1
positive regulation of biological process (GO:0048518)	1.2	4	LHX3, PROP1, OTX2, POU1F1
anatomical structure morphogenesis (GO:0009653)	2.53	4	LHX3, PROP1, LHX4, HESX1
positive regulation of metabolic process (GO:0009893)	1.74	4	LHX3, PROP1, OTX2, POU1F1
negative regulation of metabolic process (GO:0009892)	1.93	3	PROP1, POU1F1, HESX1
negative regulation of biosynthetic process (GO:0009890)	2.47	3	PROP1, POU1F1, HESX1
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	3	PROP1, HESX1, POU1F1
negative regulation of cellular metabolic process (GO:0031324)	2.01	3	PROP1, HESX1, POU1F1
negative regulation of gene expression (GO:0010629)	2.48	3	PROP1, HESX1, POU1F1
axon guidance (GO:0007411)	4.44	3	LHX3, OTX2, LHX4
regulation of cell death (GO:0010941)	2.43	3	LHX3, PROP1, LHX4
regulation of apoptotic process (GO:0042981)	2.5	3	LHX3, PROP1, LHX4
multicellular organism development (GO:0007275)	2.54	3	LHX3, OTX2, HESX1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	3	PROP1, HESX1, POU1F1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	3	PROP1, POU1F1, HESX1
regulation of programmed cell death (GO:0043067)	2.49	3	LHX3, PROP1, LHX4
negative regulation of apoptotic process (GO:0043066)	3.04	3	LHX3, PROP1, LHX4
transcription from RNA polymerase II promoter (GO:0006366)	3.38	3	PROP1, OTX2, POU1F1
negative regulation of programmed cell death (GO:0043069)	3.02	3	LHX3, PROP1, LHX4
organ morphogenesis (GO:0009887)	3.55	3	LHX3, PROP1, LHX4
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	3	PROP1, POU1F1, HESX1
neuron differentiation (GO:0030182)	4.17	3	LHX3, OTX2, LHX4
negative regulation of cell death (GO:0060548)	2.95	3	LHX3, PROP1, LHX4
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	3	PROP1, HESX1, POU1F1
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	3	PROP1, POU1F1, HESX1
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	3	PROP1, HESX1, POU1F1
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	3	PROP1, HESX1, POU1F1
neuron projection guidance (GO:0097485)	4.43	3	LHX3, OTX2, LHX4
negative regulation of RNA metabolic process (GO:0051253)	2.66	3	PROP1, POU1F1, HESX1
gland development (GO:0048732)	4.15	3	LHX3, PROP1, POU1F1
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	3	PROP1, HESX1, POU1F1
cell differentiation in spinal cord (GO:0021515)	6.02	2	LHX3, LHX4
regulation of signaling (GO:0023051)	1.72	2	OTX2, POU1F1
regulation of response to stimulus (GO:0048583)	1.54	2	OTX2, POU1F1
motor neuron axon guidance (GO:0008045)	6.4	2	LHX3, LHX4
pituitary gland development (GO:0021983)	6.33	2	LHX3, POU1F1
regulation of cell communication (GO:0010646)	1.73	2	OTX2, POU1F1
adenohypophysis development (GO:0021984)	7.53	2	PROP1, POU1F1
pattern specification process (GO:0007389)	3.79	2	LHX3, PROP1
reproductive process (GO:0022414)	2.55	2	LHX3, LHX4
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	2	PROP1, POU1F1
regulation of signal transduction (GO:0009966)	1.84	2	OTX2, POU1F1
cell fate specification (GO:0001708)	5.57	2	LHX3, POU1F1
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	2	OTX2, HESX1
reproductive structure development (GO:0048608)	4.08	2	LHX3, LHX4
medial motor column neuron differentiation (GO:0021526)	9.04	2	LHX3, LHX4
regulation of developmental process (GO:0050793)	2.1	2	OTX2, POU1F1
developmental process involved in reproduction (GO:0003006)	3.36	2	LHX3, LHX4
regionalization (GO:0003002)	4.24	2	LHX3, PROP1
regulation of multicellular organismal process (GO:0051239)	1.87	2	OTX2, POU1F1
placenta development (GO:0001890)	5.99	2	LHX3, LHX4
single organism reproductive process (GO:0044702)	2.73	2	LHX3, LHX4
dorsal/ventral pattern formation (GO:0009953)	5.6	2	LHX3, PROP1
positive regulation of developmental process (GO:0051094)	2.77	2	OTX2, POU1F1
positive regulation of multicellular organismal process (GO:0051240)	2.49	2	OTX2, POU1F1
somatotropin secreting cell differentiation (GO:0060126)	8.34	2	PROP1, POU1F1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
anatomical structure development (GO:0048856)	-	1.58	0.002	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of cellular biosynthetic process (GO:0031326)	-	1.38	0.026	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	-	2.6	0.013	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
negative regulation of gene expression (GO:0010629)	-	2.48	0.011	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
motor neuron axon guidance (GO:0008045)	-	6.4	0.001	LHX3, OTX2, LHX4
axon guidance (GO:0007411)	-	4.44	0.034	LHX3, OTX2, LHX4
anatomical structure morphogenesis (GO:0009653)	-	2.53	0.002	LHX3, PROP1, LHX4, HESX1, OTX2
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	-	3.12	0.001	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
cellular developmental process (GO:0048869)	-	1.82	0.04	LHX3, PROP1, LHX4, POU1F1, OTX2
cell fate specification (GO:0001708)	-	5.57	0.016	LHX3, OTX2, POU1F1
regulation of cellular macromolecule biosynthetic process (GO:2000112)	-	1.46	0.017	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
otic vesicle formation (GO:0030916)	NEW	7.78	0.007	OTX2, HESX1
negative regulation of apoptotic process (GO:0043066)	-	3.04	0.001	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
negative regulation of programmed cell death (GO:0043069)	-	3.02	0.001	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of gene expression (GO:0010468)	-	1.37	0.03	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
developmental process (GO:0032502)	-	1.36	0.047	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
locomotory behavior (GO:0007626)	NEW	4.53	0.015	LHX3, OTX2, LHX4, HESX1
reproductive structure development (GO:0048608)	-	4.08	0.047	LHX3, OTX2, LHX4, HESX1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	-	2.55	0.015	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
medial motor column neuron differentiation (GO:0021526)	-	9.04	0.0	LHX3, LHX4
spinal cord association neuron differentiation (GO:0021527)	NEW	7.16	0.029	LHX3, OTX2
regulation of nucleobase-containing compound metabolic process (GO:0019219)	-	1.43	0.045	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
negative regulation of cell death (GO:0060548)	-	2.95	0.002	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of biosynthetic process (GO:0009889)	-	1.37	0.028	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
negative regulation of RNA biosynthetic process (GO:1902679)	-	2.7	0.007	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
developmental process involved in reproduction (GO:0003006)	-	3.36	0.044	LHX3, LHX4, OTX2, POU1F1, HESX1
negative regulation of transcription, DNA-templated (GO:0045892)	-	2.75	0.006	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
positive regulation of transcription, DNA-templated (GO:0045893)	-	2.56	0.05	LHX3, PROP1, OTX2, POU1F1
regulation of RNA biosynthetic process (GO:2001141)	-	1.55	0.011	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
neuron projection guidance (GO:0097485)	-	4.43	0.034	LHX3, OTX2, LHX4
placenta development (GO:0001890)	-	5.99	0.013	LHX3, LHX4
single-organism developmental process (GO:0044767)	-	1.49	0.027	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
dorsal/ventral pattern formation (GO:0009953)	-	5.6	0.043	LHX3, PROP1, OTX2
negative regulation of RNA metabolic process (GO:0051253)	-	2.66	0.008	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of RNA metabolic process (GO:0051252)	-	1.52	0.013	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
forebrain morphogenesis (GO:0048853)	NEW	7.43	0.026	OTX2, HESX1
regulation of transcription, DNA-templated (GO:0006355)	-	1.56	0.011	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regulation of macromolecule biosynthetic process (GO:0010556)	-	1.43	0.021	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	-	2.81	0.015	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
regionalization (GO:0003002)	-	4.24	0.035	LHX3, PROP1, OTX2, POU1F1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular membrane-bounded organelle (GO:0043231)	0.6	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
nucleus (GO:0005634)	1.07	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
cell part (GO:0044464)	0.11	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
intracellular organelle (GO:0043229)	0.51	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
intracellular part (GO:0044424)	0.28	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
membrane-bounded organelle (GO:0043227)	0.47	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
organelle (GO:0043226)	0.4	6	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
protein complex (GO:0043234)	1.51	4	LHX3, PROP1, OTX2, POU1F1
macromolecular complex (GO:0032991)	1.35	4	LHX3, PROP1, OTX2, POU1F1
transcription factor complex (GO:0005667)	4.1	3	LHX3, PROP1, POU1F1
intracellular (GO:0005622)	2.37	2	LHX3, LHX4

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
nucleus (GO:0005634)	-	1.07	0.012	LHX3, OTX2, HESX1, LHX4, PROP1, POU1F1
transcription factor complex (GO:0005667)	-	4.1	0.046	LHX3, PROP1, HESX1, POU1F1, OTX2