Disease table of GRANULOMATOUS DISEASE, CHRONIC OMIM ID: PS306400

Gene-disease associations table

Gene	Associated with GRANULOMATOUS DISEASE, CHRONIC in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
CYBB	ClinVar, OMIM, HUMSAVAR	HGNC link	Xp21.1	2	PS306400, 300645
NCF2	ClinVar, OMIM, HUMSAVAR	HGNC link	1q25.3	1	PS306400
NCF1	ClinVar, OMIM, HUMSAVAR	HGNC link	7q11.23	1	PS306400
CYBA	ClinVar, OMIM, HUMSAVAR	HGNC link	16q24.2	1	PS306400
NCF4	ClinVar, OMIM, HUMSAVAR	HGNC link	22q12.3	1	PS306400

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
IRF1	NO	51	EIF2AK2, IFNA13, PSMB10, IL12A, NCF2, CEACAM1, MMP9, MYB, PSMB9, IL12B, TAP2, CCNE1, CCL5, SOCS2, VCAM1, TNFSF10, SOCS1, MAPK14, IFNA1, HLA-G, CASP7, CDKN1A, IFNB1, CCNB1, FOXP3, OGN, PIGR, IL10, TAP1, TP53, TRIM22, HLA-A, DDX58, CD40, ERAP2, IL27, CDK1, E2F1, TAPBP, CYBB, CDK2, BCL2, CDK4, CXCL10, SLPI, IRF2, DST, IFIT3, CIITA, IFNG, FASLG	2	NCF2, CYBB
SPI1	NO	59	ALOX15, PARG, TEC, MS4A1, FCER1A, ITGA2B, FCGR1A, SCARB1, CD22, MSR1, IL12B, CD40, NSFL1C, CLEC4G, IL5, BCL6, CCL5, IGJ, BPI, ELANE, TNF, ITGAM, PTGIR, FLI1, IL1B, MACROD1, MNDA, P2RY10, NCF2, CSF2RA, ZNF300, TNFRSF11A, ACP5, WAS, CTSS, CD163, ITGB2, CYBB, SCARB2, CXCR1, CD68, ERAP2, CSF1, RNASE2, ITGAX, PRG2, MAPK1, IL18, CSF3R, PEBP1, FES, CTSK, TLR4, IFIT3, BTK, GATA1, MME, CTSG, PRTN3	2	NCF2, CYBB
IRF8	NO	11	NCF2, TLR3, IL12A, JAK1, C1QB, NF1, CYBB, IL1B, CFLAR, CD68, TLR4	2	NCF2, CYBB

regulated gene	associated to this disease	# TFs	TFs
CYBB	YES	9	CUX1, SPI1, IRF8, IRF1, SATB1, GATA1, EP300, GATA2, ELF1
NCF2	YES	5	IRF1, MED15, SPI1, PLAGL2, IRF8
NCF1	YES	1	HBP1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
CYBB	NCF1	No	1	ACTB
NCF2	NCF1	Yes	7	NCF4, PRKDC, SYTL1, CYBA, GNAI1, TRAF4, NCF1
NCF2	CYBA	Yes	1	NCF1
NCF2	NCF4	Yes	2	PRKDC, NCF1
NCF1	CYBA	Yes	2	NCF2, NCF1
NCF1	NCF4	Yes	4	MSN, NCF2, PRKDC, NCF1
CYBA	NCF4	No	2	NCF2, NCF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
NCF2	NCF1	Yes	3	NCF2, NCF4, NCF1
NCF2	CYBA	No	1	NCF1
NCF2	NCF4	Yes	3	NCF2, NCF4, NCF1
NCF1	CYBA	Yes	2	CYBA, NCF1
NCF1	NCF4	Yes	3	NCF2, NCF4, NCF1
CYBA	NCF4	No	1	NCF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Leukocyte transendothelial migration	hsa04670	5.74	5	CYBA, NCF2, NCF4, NCF1, CYBB
Phagosome	hsa04145	5.27	5	CYBA, NCF2, NCF4, NCF1, CYBB
Osteoclast differentiation	hsa04380	5.64	5	CYBA, NCF2, NCF4, NCF1, CYBB
Leishmaniasis	hsa05140	6.32	4	NCF2, NCF4, CYBA, NCF1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Cellular Processes	NEW	2.22	0.008	CYBA, NCF2, NCF4, NCF1, CYBB
Infectious diseases: Parasitic	NEW	4.46	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Leishmaniasis (hsa05140)	-	6.32	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Leukocyte transendothelial migration (hsa04670)	-	5.74	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Phagosome (hsa04145)	-	5.27	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Immune system	NEW	2.92	0.022	CYBA, NCF2, NCF4, NCF1, CYBB
Osteoclast differentiation (hsa04380)	-	5.64	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
HIF-1 signaling pathway (hsa04066)	NEW	5.9	0.0	CYBA, NCF2, NCF1, CYBB
Transport and catabolism	NEW	3.49	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Development	NEW	4.58	0.0	CYBA, NCF2, NCF4, NCF1, CYBB

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Phagosomal maturation (early endosomal stage)	R-HSA-1222556	7.89	5	CYBA, NCF2, NCF4, NCF1, CYBB
RHO GTPases Activate NADPH Oxidases	R-HSA-5668599	9.52	5	CYBA, NCF2, NCF4, NCF1, CYBB
RHO GTPase Effectors	R-HSA-195258	4.94	5	CYBA, NCF2, NCF4, NCF1, CYBB
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	5	CYBA, NCF2, NCF4, NCF1, CYBB
Signaling by VEGF	R-HSA-194138	4.66	5	CYBA, NCF2, NCF4, NCF1, CYBB
Antigen processing-Cross presentation	R-HSA-1236975	5.88	5	CYBA, NCF2, NCF4, NCF1, CYBB
Cross-presentation of particulate exogenous antigens (phagosomes)	R-HSA-1236973	9.98	5	CYBA, NCF2, NCF4, NCF1, CYBB
Immune System	R-HSA-168256	2.37	5	CYBA, NCF2, NCF4, NCF1, CYBB
Signaling by Rho GTPases	R-HSA-194315	4.43	5	CYBA, NCF2, NCF4, NCF1, CYBB
Infectious disease	R-HSA-5663205	4.47	5	CYBA, NCF2, NCF4, NCF1, CYBB
Class I MHC mediated antigen processing & presentation	R-HSA-983169	4.65	5	CYBA, NCF2, NCF4, NCF1, CYBB
Disease	R-HSA-1643685	3.33	5	CYBA, NCF2, NCF4, NCF1, CYBB
Latent infection of Homo sapiens with Mycobacterium tuberculosis	R-HSA-1222352	7.89	5	CYBA, NCF2, NCF4, NCF1, CYBB
Adaptive Immune System	R-HSA-1280218	3.19	5	CYBA, NCF2, NCF4, NCF1, CYBB
Signal Transduction	R-HSA-162582	1.78	5	CYBA, NCF2, NCF4, NCF1, CYBB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Infectious disease (R-HSA-5663205)	-	4.47	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
RHO GTPases Activate NADPH Oxidases (R-HSA-5668599)	-	9.52	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
RHO GTPase Effectors (R-HSA-195258)	-	4.94	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
VEGFA-VEGFR2 Pathway (R-HSA-4420097)	-	4.7	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Signaling by VEGF (R-HSA-194138)	-	4.66	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Immune System (R-HSA-168256)	-	2.37	0.004	CYBA, NCF2, NCF4, NCF1, CYBB
Cross-presentation of particulate exogenous antigens (phagosomes) (R-HSA-1236973)	-	9.98	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Antigen processing-Cross presentation (R-HSA-1236975)	-	5.88	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Signaling by Rho GTPases (R-HSA-194315)	-	4.43	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Class I MHC mediated antigen processing & presentation (R-HSA-983169)	-	4.65	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Signal Transduction (R-HSA-162582)	-	1.78	0.033	CYBA, NCF2, NCF4, NCF1, CYBB
Latent infection of Homo sapiens with Mycobacterium tuberculosis (R-HSA-1222352)	-	7.89	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Phagosomal maturation (early endosomal stage) (R-HSA-1222556)	-	7.89	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
Adaptive Immune System (R-HSA-1280218)	-	3.19	0.025	CYBA, NCF2, NCF4, NCF1, CYBB
Disease (R-HSA-1643685)	-	3.33	0.0	CYBA, NCF2, NCF4, NCF1, CYBB

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	5	CYBA, NCF2, NCF4, NCF1, CYBB
protein binding (GO:0005515)	0.46	5	CYBA, NCF2, NCF4, NCF1, CYBB
oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor (GO:0050664)	6.97	4	CYBA, NCF2, NCF1, CYBB
superoxide-generating NADPH oxidase activity (GO:0016175)	7.34	4	CYBA, NCF2, NCF1, CYBB
catalytic activity (GO:0003824)	1.05	4	CYBA, NCF2, NCF1, CYBB
oxidoreductase activity, acting on NAD(P)H (GO:0016651)	5.13	4	CYBA, NCF2, NCF1, CYBB
oxidoreductase activity (GO:0016491)	3.12	4	CYBA, NCF2, NCF1, CYBB
electron carrier activity (GO:0009055)	4.97	4	CYBA, NCF2, NCF1, CYBB
protein dimerization activity (GO:0046983)	2.72	3	CYBA, NCF4, CYBB
ion binding (GO:0043167)	1.36	3	CYBA, NCF1, CYBB
cation binding (GO:0043169)	1.4	2	CYBA, CYBB
protein heterodimerization activity (GO:0046982)	3.64	2	CYBA, CYBB
heme binding (GO:0020037)	4.86	2	CYBA, CYBB
tetrapyrrole binding (GO:0046906)	4.8	2	CYBA, CYBB
phosphatidylinositol binding (GO:0035091)	4.47	2	NCF4, NCF1
organic cyclic compound binding (GO:0097159)	1.05	2	CYBA, CYBB
phospholipid binding (GO:0005543)	3.91	2	NCF4, NCF1
SH3 domain binding (GO:0017124)	4.98	2	CYBA, NCF1
lipid binding (GO:0008289)	3.26	2	NCF4, NCF1
protein domain specific binding (GO:0019904)	3.32	2	CYBA, NCF1
metal ion binding (GO:0046872)	1.41	2	CYBA, CYBB
heterocyclic compound binding (GO:1901363)	1.06	2	CYBA, CYBB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
substrate-specific transporter activity (GO:0022892)	NEW	2.72	0.004	CYBA, NCF2, NCF4, NCF1, CYBB
heme binding (GO:0020037)	-	4.86	0.038	CYBA, CYBB
tetrapyrrole binding (GO:0046906)	-	4.8	0.043	CYBA, CYBB
transporter activity (GO:0005215)	NEW	2.57	0.01	CYBA, NCF2, NCF4, NCF1, CYBB
oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor (GO:0050664)	-	6.97	0.0	CYBA, NCF1, CYBB
superoxide-generating NADPH oxidase activity (GO:0016175)	-	7.34	0.0	CYBA, NCF1, CYBB
SH3 domain binding (GO:0017124)	-	4.98	0.024	CYBA, NCF1
enzyme binding (GO:0019899)	NEW	2.27	0.041	CYBA, NCF2, NCF4, NCF1, CYBB
Ras GTPase binding (GO:0017016)	NEW	4.2	0.017	NCF2, CYBA, NCF1
ion transmembrane transporter activity (GO:0015075)	NEW	3.04	0.046	NCF2, NCF4, CYBA, CYBB
small GTPase binding (GO:0031267)	NEW	4.13	0.02	NCF2, CYBA, NCF1
GTPase binding (GO:0051020)	NEW	4.05	0.026	NCF2, CYBA, NCF1
oxidoreductase activity, acting on NAD(P)H (GO:0016651)	-	5.13	0.02	CYBA, NCF2, NCF1, CYBB
phosphatidylinositol phosphate binding (GO:1901981)	NEW	5.05	0.013	NCF4, NCF1
electron carrier activity (GO:0009055)	-	4.97	0.002	NCF2, CYBA, NCF1
oxidoreductase activity (GO:0016491)	-	3.12	0.001	CYBA, NCF2, NCF4, NCF1, CYBB

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
homeostatic process (GO:0042592)	2.61	5	CYBA, NCF2, NCF4, NCF1, CYBB
antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	5.54	5	CYBA, NCF2, NCF4, NCF1, CYBB
signal transduction (GO:0007165)	1.28	5	CYBA, NCF2, NCF4, NCF1, CYBB
cell surface receptor signaling pathway (GO:0007166)	2.09	5	CYBA, NCF2, NCF4, NCF1, CYBB
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	5	CYBA, NCF2, NCF4, NCF1, CYBB
antigen processing and presentation of peptide antigen (GO:0048002)	4.56	5	CYBA, NCF2, NCF4, NCF1, CYBB
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	5	CYBA, NCF2, NCF4, NCF1, CYBB
regulation of biological process (GO:0050789)	0.45	5	CYBA, NCF2, NCF4, NCF1, CYBB
single-organism process (GO:0044699)	0.48	5	CYBA, NCF2, NCF4, NCF1, CYBB
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	5.19	5	CYBA, NCF2, NCF4, NCF1, CYBB
single-organism metabolic process (GO:0044710)	1.63	5	CYBA, NCF2, NCF4, NCF1, CYBB
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479)	5.59	5	CYBA, NCF2, NCF4, NCF1, CYBB
antigen processing and presentation of exogenous peptide antigen (GO:0002478)	4.63	5	CYBA, NCF2, NCF4, NCF1, CYBB
biological regulation (GO:0065007)	0.39	5	CYBA, NCF2, NCF4, NCF1, CYBB
regulation of biological quality (GO:0065008)	1.68	5	CYBA, NCF2, NCF4, NCF1, CYBB
cellular homeostasis (GO:0019725)	3.23	5	CYBA, NCF2, NCF4, NCF1, CYBB
antigen processing and presentation (GO:0019882)	4.36	5	CYBA, NCF2, NCF4, NCF1, CYBB
antigen processing and presentation of exogenous antigen (GO:0019884)	4.59	5	CYBA, NCF2, NCF4, NCF1, CYBB
cellular process (GO:0009987)	0.26	5	CYBA, NCF2, NCF4, NCF1, CYBB
regulation of cellular process (GO:0050794)	0.5	5	CYBA, NCF2, NCF4, NCF1, CYBB
single-organism cellular process (GO:0044763)	0.65	5	CYBA, NCF2, NCF4, NCF1, CYBB
metabolic process (GO:0008152)	0.58	5	CYBA, NCF2, NCF4, NCF1, CYBB
immune response (GO:0006955)	2.86	5	CYBA, NCF2, NCF4, NCF1, CYBB
vascular endothelial growth factor receptor signaling pathway (GO:0048010)	5.44	5	CYBA, NCF2, NCF4, NCF1, CYBB
cell redox homeostasis (GO:0045454)	5.52	5	CYBA, NCF2, NCF4, NCF1, CYBB
oxidation-reduction process (GO:0055114)	2.91	5	CYBA, NCF2, NCF4, NCF1, CYBB
response to stimulus (GO:0050896)	1.22	5	CYBA, NCF2, NCF4, NCF1, CYBB
immune system process (GO:0002376)	2.29	5	CYBA, NCF2, NCF4, NCF1, CYBB
superoxide anion generation (GO:0042554)	7.09	4	CYBA, NCF2, NCF1, CYBB
cellular metabolic process (GO:0044237)	0.69	4	CYBA, NCF2, NCF1, CYBB
innate immune response (GO:0045087)	3.55	4	CYBA, NCF2, NCF1, CYBB
reactive oxygen species metabolic process (GO:0072593)	5.14	4	CYBA, NCF2, NCF1, CYBB
defense response (GO:0006952)	2.78	4	CYBA, NCF2, NCF1, CYBB
response to stress (GO:0006950)	1.8	4	CYBA, NCF2, NCF1, CYBB
respiratory burst (GO:0045730)	6.96	4	CYBA, NCF2, NCF1, CYBB
superoxide metabolic process (GO:0006801)	6.23	4	CYBA, NCF2, NCF1, CYBB
response to oxygen-containing compound (GO:1901700)	2.57	2	CYBA, CYBB
regulation of localization (GO:0032879)	1.94	2	CYBA, CYBB
hydrogen peroxide biosynthetic process (GO:0050665)	7.53	2	CYBA, CYBB
regulation of ion transport (GO:0043269)	3.4	2	CYBA, CYBB
reactive oxygen species biosynthetic process (GO:1903409)	6.59	2	CYBA, CYBB
regulation of transport (GO:0051049)	2.24	2	CYBA, CYBB
transport (GO:0006810)	1.51	2	NCF1, CYBB
cellular component organization (GO:0016043)	1.24	2	CYBA, NCF1
response to reactive oxygen species (GO:0000302)	4.5	2	CYBA, CYBB
cellular biosynthetic process (GO:0044249)	1.37	2	CYBA, CYBB
biosynthetic process (GO:0009058)	1.32	2	CYBA, CYBB
cellular defense response (GO:0006968)	5.65	2	NCF2, NCF1
hydrogen peroxide metabolic process (GO:0042743)	6.33	2	CYBA, CYBB
regulation of transmembrane transport (GO:0034762)	3.74	2	CYBA, CYBB
inflammatory response (GO:0006954)	3.64	2	CYBA, CYBB
response to chemical (GO:0042221)	1.98	2	CYBA, CYBB
regulation of ion transmembrane transport (GO:0034765)	3.77	2	CYBA, CYBB
localization (GO:0051179)	1.4	2	NCF1, CYBB
establishment of localization (GO:0051234)	1.48	2	NCF1, CYBB
response to oxidative stress (GO:0006979)	3.9	2	CYBA, CYBB
cellular component organization or biogenesis (GO:0071840)	1.22	2	CYBA, NCF1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cellular defense response (GO:0006968)	-	5.65	0.0	NCF2, NCF4, NCF1, CYBB
positive regulation of stress-activated MAPK cascade (GO:0032874)	NEW	4.82	0.008	CYBA, NCF1, CYBB
antigen processing and presentation (GO:0019882)	-	4.36	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	-	5.54	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
hydrogen peroxide metabolic process (GO:0042743)	-	6.33	0.0	CYBA, NCF2, NCF1, CYBB
superoxide metabolic process (GO:0006801)	-	6.23	0.0	CYBA, NCF2, NCF1, CYBB
antigen processing and presentation of peptide antigen (GO:0048002)	-	4.56	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
response to organic cyclic compound (GO:0014070)	NEW	3.07	0.018	CYBA, NCF2, NCF4, NCF1, CYBB
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)	-	5.19	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
superoxide anion generation (GO:0042554)	-	7.09	0.0	CYBA, NCF2, NCF1, CYBB
hydrogen peroxide biosynthetic process (GO:0050665)	-	7.53	0.0	CYBA, NCF1, CYBB
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:0002479)	-	5.59	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
antigen processing and presentation of exogenous peptide antigen (GO:0002478)	-	4.63	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
phagosome maturation (GO:0090382)	NEW	7.94	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
interspecies interaction between organisms (GO:0044419)	NEW	3.08	0.007	CYBA, NCF2, NCF4, NCF1, CYBB
response to oxygen levels (GO:0070482)	NEW	4.02	0.016	NCF2, NCF4, CYBA, CYBB
detection of external stimulus (GO:0009581)	NEW	4.98	0.004	CYBA, NCF2, NCF1, CYBB
detection of abiotic stimulus (GO:0009582)	NEW	4.96	0.004	CYBA, NCF2, NCF1, CYBB
antigen processing and presentation of exogenous antigen (GO:0019884)	-	4.59	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
reactive oxygen species biosynthetic process (GO:1903409)	-	6.59	0.0	CYBA, NCF1, CYBB
innate immune response (GO:0045087)	-	3.55	0.004	CYBA, NCF2, NCF4, NCF1, CYBB
reactive oxygen species metabolic process (GO:0072593)	-	5.14	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
defense response (GO:0006952)	-	2.78	0.03	CYBA, NCF2, NCF1, CYBB
positive regulation of stress-activated protein kinase signaling cascade (GO:0070304)	NEW	4.82	0.008	CYBA, NCF1, CYBB
inflammatory response (GO:0006954)	-	3.64	0.02	CYBA, NCF1, CYBB
immune response (GO:0006955)	-	2.86	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
interaction with host (GO:0051701)	NEW	4.86	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
oxidation-reduction process (GO:0055114)	-	2.91	0.032	CYBA, NCF2, NCF4, NCF1, CYBB
multi-organism process (GO:0051704)	NEW	2.65	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
organelle organization (GO:0006996)	NEW	2.02	0.003	CYBA, NCF2, NCF4, NCF1, CYBB
detection of stimulus (GO:0051606)	NEW	3.22	0.001	CYBA, NCF2, NCF4, NCF1, CYBB
response to external stimulus (GO:0009605)	NEW	2.55	0.033	CYBA, NCF2, NCF1, CYBB
positive regulation of blood pressure (GO:0045777)	NEW	6.26	0.007	NCF2, CYBA
response to drug (GO:0042493)	NEW	3.71	0.016	NCF2, CYBA, CYBB
immune system process (GO:0002376)	-	2.29	0.003	CYBA, NCF2, NCF4, NCF1, CYBB
respiratory burst (GO:0045730)	-	6.96	0.0	CYBA, NCF2, NCF1, CYBB

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cytoplasm (GO:0005737)	1.01	5	CYBA, NCF2, NCF4, NCF1, CYBB
protein complex (GO:0043234)	1.51	5	CYBA, NCF2, NCF4, NCF1, CYBB
macromolecular complex (GO:0032991)	1.35	5	CYBA, NCF2, NCF4, NCF1, CYBB
catalytic complex (GO:1902494)	2.9	5	CYBA, NCF2, NCF4, NCF1, CYBB
plasma membrane part (GO:0044459)	1.95	5	CYBA, NCF2, NCF4, NCF1, CYBB
cell part (GO:0044464)	0.11	5	CYBA, NCF2, NCF4, NCF1, CYBB
cytoplasmic part (GO:0044444)	0.82	5	CYBA, NCF2, NCF4, NCF1, CYBB
oxidoreductase complex (GO:1990204)	5.19	5	CYBA, NCF2, NCF4, NCF1, CYBB
plasma membrane protein complex (GO:0098797)	3.55	5	CYBA, NCF2, NCF4, NCF1, CYBB
membrane protein complex (GO:0098796)	2.84	5	CYBA, NCF2, NCF4, NCF1, CYBB
intracellular organelle (GO:0043229)	0.51	5	CYBA, NCF2, NCF4, NCF1, CYBB
membrane part (GO:0044425)	0.95	5	CYBA, NCF2, NCF4, NCF1, CYBB
intracellular part (GO:0044424)	0.28	5	CYBA, NCF2, NCF4, NCF1, CYBB
NADPH oxidase complex (GO:0043020)	7.5	5	CYBA, NCF2, NCF4, NCF1, CYBB
membrane-bounded organelle (GO:0043227)	0.47	5	CYBA, NCF2, NCF4, NCF1, CYBB
organelle (GO:0043226)	0.4	5	CYBA, NCF2, NCF4, NCF1, CYBB
intracellular membrane-bounded organelle (GO:0043231)	0.6	5	CYBA, NCF2, NCF4, NCF1, CYBB
vesicle (GO:0031982)	1.64	4	NCF2, NCF4, CYBA, NCF1
vacuole (GO:0005773)	2.92	4	NCF2, NCF4, CYBA, NCF1
cytoplasmic vesicle (GO:0031410)	2.87	4	NCF2, NCF4, CYBA, NCF1
membrane (GO:0016020)	0.68	4	CYBA, NCF4, NCF1, CYBB
membrane-bounded vesicle (GO:0031988)	1.71	4	NCF2, NCF4, CYBA, NCF1
intracellular organelle part (GO:0044446)	0.81	4	NCF2, NCF4, CYBA, CYBB
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	4	NCF2, NCF4, CYBA, NCF1
intracellular vesicle (GO:0097708)	2.86	4	NCF2, NCF4, CYBA, NCF1
organelle part (GO:0044422)	0.79	4	NCF2, NCF4, CYBA, CYBB
lysosome (GO:0005764)	3.89	3	NCF2, NCF4, NCF1
cytosol (GO:0005829)	1.68	3	NCF2, NCF4, NCF1
lytic vacuole (GO:0000323)	3.89	3	NCF2, NCF4, NCF1
organelle membrane (GO:0031090)	1.97	3	CYBA, NCF4, CYBB
whole membrane (GO:0098805)	2.85	3	CYBA, NCF4, CYBB
endocytic vesicle (GO:0030139)	5.04	3	NCF2, NCF4, NCF1
phagocytic vesicle (GO:0045335)	5.91	3	NCF2, NCF4, NCF1
secondary lysosome (GO:0005767)	7.86	3	NCF2, NCF4, NCF1
phagolysosome (GO:0032010)	8.42	3	NCF2, NCF4, NCF1
bounding membrane of organelle (GO:0098588)	2.39	3	CYBA, NCF4, CYBB
endocytic vesicle membrane (GO:0030666)	4.82	2	CYBA, CYBB
phagocytic vesicle membrane (GO:0030670)	5.71	2	CYBA, CYBB
secretory vesicle (GO:0099503)	4.0	2	NCF2, CYBA
cytoplasmic vesicle membrane (GO:0030659)	3.67	2	CYBA, CYBB
secretory granule (GO:0030141)	4.34	2	NCF2, CYBA
integral component of membrane (GO:0016021)	1.14	2	CYBA, CYBB
mitochondrion (GO:0005739)	2.42	2	CYBA, CYBB
endoplasmic reticulum membrane (GO:0005789)	2.95	2	CYBA, CYBB
cytoplasmic vesicle part (GO:0044433)	3.41	2	CYBA, CYBB
endoplasmic reticulum part (GO:0044432)	2.73	2	CYBA, CYBB
vesicle membrane (GO:0012506)	3.63	2	CYBA, CYBB
plasma membrane (GO:0005886)	1.39	2	CYBA, CYBB
endosome (GO:0005768)	3.25	2	CYBA, NCF4
intrinsic component of membrane (GO:0031224)	1.13	2	CYBA, CYBB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
lytic vacuole (GO:0000323)	-	3.89	0.001	NCF2, NCF4, NCF1, CYBB
dendrite (GO:0030425)	NEW	3.92	0.001	CYBA, NCF1, CYBB
oxidoreductase complex (GO:1990204)	-	5.19	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
endocytic vesicle (GO:0030139)	-	5.04	0.0	NCF2, NCF4, NCF1, CYBB
endocytic vesicle membrane (GO:0030666)	-	4.82	0.01	CYBA, NCF1, CYBB
vacuole (GO:0005773)	-	2.92	0.001	NCF2, NCF4, NCF1, CYBB
cytoplasmic vesicle (GO:0031410)	-	2.87	0.001	NCF2, NCF4, CYBA, NCF1
neuron projection (GO:0043005)	NEW	3.12	0.017	CYBA, NCF1, CYBB
phagolysosome (GO:0032010)	-	8.42	0.0	NCF2, NCF4, NCF1
NADPH oxidase complex (GO:0043020)	-	7.5	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
neuronal cell body (GO:0043025)	NEW	3.9	0.002	CYBA, NCF1, CYBB
Golgi apparatus (GO:0005794)	NEW	2.7	0.043	CYBA, NCF1, CYBB
rough endoplasmic reticulum (GO:0005791)	NEW	5.83	0.002	NCF1, CYBB
catalytic complex (GO:1902494)	-	2.9	0.0	CYBA, NCF2, NCF4, NCF1, CYBB
cell body (GO:0044297)	NEW	3.74	0.003	CYBA, NCF1, CYBB
phagocytic vesicle (GO:0045335)	-	5.91	0.0	NCF2, NCF4, NCF1
protein complex (GO:0043234)	-	1.51	0.027	CYBA, NCF2, NCF4, NCF1, CYBB
phagocytic vesicle membrane (GO:0030670)	-	5.71	0.02	CYBA, CYBB
plasma membrane part (GO:0044459)	-	1.95	0.002	CYBA, NCF2, NCF4, NCF1, CYBB
lysosome (GO:0005764)	-	3.89	0.001	NCF2, NCF4, NCF1, CYBB
cytoplasmic membrane-bounded vesicle (GO:0016023)	-	3.12	0.001	CYBA, NCF2, NCF4, NCF1, CYBB
secondary lysosome (GO:0005767)	-	7.86	0.0	NCF2, NCF4, NCF1