Disease table of TRICHOTHIODYSTROPHY OMIM ID: PS601675

Gene-disease associations table

GeneAssociated with TRICHOTHIODYSTROPHY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ERCC2ClinVar, OMIM, HUMSAVARHGNC link19q13.323278730, PS601675, PS214150
ERCC3ClinVar, OMIM, HUMSAVARHGNC link2q14.32610651, PS601675
MPLKIPClinVar, OMIM, HUMSAVARHGNC link7p14.11PS601675
GTF2H5ClinVar, OMIM, HUMSAVARHGNC link6q25.31PS601675
RNF113AClinVar, OMIMHGNC linkXq241PS601675

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
ERCC2YES5LAMTOR5, CDKN1A, BAX, TP53, BCL20
ERCC3YES1CDK70
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
ERCC2YES1HIF1A0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ERCC2ERCC3Yes18UVSSA, ERCC5, AR, CDK7, GTF2H2, MMS19, GTF2H2C_2, GTF2H5, TP53, MNAT1, REV, CCNH, ERCC6, ATF7IP, RAD52, TAT, GTF2H1, GTF2H3
ERCC2MPLKIPNo2CDK7, XPO1
ERCC2GTF2H5Yes8ERCC5, GTF2H2, GTF2H1, CCNH, CDK7, ERCC3, MNAT1, GTF2H3
ERCC3MPLKIPNo1CDK7
ERCC3GTF2H5Yes9ERCC5, GTF2H2, ERCC2, GTF2H1, CCNH, GTF2H4, CDK7, MNAT1, GTF2H3
MPLKIPGTF2H5No1CDK7

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
ERCC2ERCC3Yesbinding105UBTF, PHKA2, CCNT1, TAF1, POLR2K, ERCC6, SUPT4H1, XPA, CDK9, RPA1, TAF13, TAF1D, PRKACB, UVSSA, GTF2E1, ELL, POLR2L, TP53, POLR2I, XAB2, TAF11, SUPT5H, GTF2E2, ERCC4, POLR1B, TCEB1, POLR2G, RNGTT, TAF4B, GTF2B, PRKAA1, PRKACA, ERCC8, NCBP2, POLR2A, DDB1, RPA2, GTF2F2, ERCC1, PRKAG1, MNAT1, DDB2, POLR2B, TAF1B, TAF10, TTF1, NCBP1, ACVR1C, UBC, POLR1D, RRN3, POLR2J, PTRF, POLR2F, CHUK, TAF12, POLR1C, TH1L, POLR2C, ERC1, TAF6, GTF2F1, ERCC5, RAD23B, TAF1A, COBRA1, PRKAG2, IKBKB, GTF2H1, CCNT2, GTF2A1, PRKAR1B, PHKG2, SSRP1, TAF5, TBP, POLR1A, TAF4, CDK7, POLR2H, ACVR1, RAD52, GTF2H2, TCEB3, PRKAR2A, TCEA1, GTF2H5, TCEB2, POLR2D, PYCARD, GTF2A2, SUPT16H, PRKAR1A, XPC, MMS19, PYDC1, FEN1, WHSC2, CCNH, TAF1C, RNMT, RPA3, POLR2E, ATF7IP, GTF2H3
ERCC2GTF2H5Yesbinding5GTF2E2, ERCC3, GTF2H3, GTF2E1, GTF2H1
ERCC3GTF2H5Yesbinding5ERCC2, GTF2E2, GTF2H3, GTF2E1, GTF2H1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
ERCC2ERCC3YesTFIIH transcription factor complex (ERCC2, ERCC3, GTF2H1, CDK7, CCNH, GTF2H2);TFIIH transcription factor complex;RNA polymerase II holoenzyme complex;BRCA1-RNA polymerase II complex28GTF2B, TBP, POLR2J, GTF2H4, POLR2I, POLR2F, POLR2C, POLR2H, GTF2H2, GTF2H1, MED21, POLR2E, POLR2D, BRCA1, GTF2F1, CDK7, GTF2E1, POLR2L, POLR2G, POLR2B, POLR2A, GTF2E2, CCNH, GTF2H5, GTF2F2, MNAT1, GTF2H3, POLR2K
ERCC2GTF2H5YesTFIIH transcription factor complex8GTF2H2, GTF2H1, CCNH, GTF2H4, CDK7, ERCC3, MNAT1, GTF2H3
ERCC3GTF2H5YesTFIIH transcription factor complex8GTF2H2, ERCC2, GTF2H1, CCNH, GTF2H4, CDK7, MNAT1, GTF2H3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ERCC2ERCC3Yes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
ERCC2ERCC3Yes5TBP, POLR2F, ERCC3, GTF2H5, ERCC2
ERCC2GTF2H5Yes5TBP, POLR2F, ERCC3, GTF2H5, ERCC2
ERCC3GTF2H5Yes5TBP, POLR2F, ERCC3, GTF2H5, ERCC2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Basal transcription factorshsa030227.313GTF2H5, ERCC3, ERCC2
Nucleotide excision repairhsa034207.153GTF2H5, ERCC3, ERCC2

NET-GE enrichment

Term New enriched termICP valueGenes
Basal transcription factors (hsa03022) -7.310.0GTF2H5, ERCC3, ERCC2
Genetic Information ProcessingNEW2.480.035GTF2H5, ERCC3, ERCC2
Replication and repairNEW5.410.0GTF2H5, ERCC3, ERCC2
TranscriptionNEW5.070.001GTF2H5, ERCC3, ERCC2
Nucleotide excision repair (hsa03420) -7.150.0GTF2H5, ERCC3, ERCC2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Global Genomic NER (GG-NER)R-HSA-1099707.893GTF2H5, ERCC3, ERCC2
Dual incision reaction in TC-NERR-HSA-1103048.123GTF2H5, ERCC3, ERCC2
Formation of transcription-coupled NER (TC-NER) repair complexR-HSA-1103028.123GTF2H5, ERCC3, ERCC2
Transcription-coupled NER (TC-NER)R-HSA-739377.493GTF2H5, ERCC3, ERCC2
Formation of incision complex in GG-NERR-HSA-739358.593GTF2H5, ERCC3, ERCC2
RNA Polymerase I Promoter EscapeR-HSA-737728.083GTF2H5, ERCC3, ERCC2
RNA Polymerase I Chain ElongationR-HSA-737777.183GTF2H5, ERCC3, ERCC2
RNA Polymerase II Promoter EscapeR-HSA-737767.523GTF2H5, ERCC3, ERCC2
RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningR-HSA-737797.523GTF2H5, ERCC3, ERCC2
RNA Polymerase I Promoter ClearanceR-HSA-738546.753GTF2H5, ERCC3, ERCC2
DiseaseR-HSA-16436853.333GTF2H5, ERCC3, ERCC2
RNA Polymerase II Pre-transcription EventsR-HSA-6746957.013GTF2H5, ERCC3, ERCC2
Transcription of the HIV genomeR-HSA-1671726.963GTF2H5, ERCC3, ERCC2
Negative epigenetic regulation of rRNA expressionR-HSA-52509416.753GTF2H5, ERCC3, ERCC2
RNA Polymerase II Transcription Initiation And Promoter ClearanceR-HSA-760427.523GTF2H5, ERCC3, ERCC2
NoRC negatively regulates rRNA expressionR-HSA-4274136.813GTF2H5, ERCC3, ERCC2
Formation of the HIV-1 Early Elongation ComplexR-HSA-1671587.943GTF2H5, ERCC3, ERCC2
HIV InfectionR-HSA-1629065.223GTF2H5, ERCC3, ERCC2
Late Phase of HIV Life CycleR-HSA-1625996.023GTF2H5, ERCC3, ERCC2
Nucleotide Excision RepairR-HSA-738857.343GTF2H5, ERCC3, ERCC2
RNA Polymerase II TranscriptionR-HSA-738576.253GTF2H5, ERCC3, ERCC2
Infectious diseaseR-HSA-56632054.473GTF2H5, ERCC3, ERCC2
Epigenetic regulation of gene expressionR-HSA-2121656.463GTF2H5, ERCC3, ERCC2
mRNA CappingR-HSA-720868.123GTF2H5, ERCC3, ERCC2
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionR-HSA-5040466.163GTF2H5, ERCC3, ERCC2
DNA RepairR-HSA-738945.83GTF2H5, ERCC3, ERCC2
RNA Pol II CTD phosphorylation and interaction with CER-HSA-770758.233GTF2H5, ERCC3, ERCC2
RNA Polymerase I Transcription InitiationR-HSA-737627.433GTF2H5, ERCC3, ERCC2
RNA Polymerase I TranscriptionR-HSA-738646.723GTF2H5, ERCC3, ERCC2
HIV Transcription InitiationR-HSA-1671617.523GTF2H5, ERCC3, ERCC2
RNA Pol II CTD phosphorylation and interaction with CER-HSA-1671608.233GTF2H5, ERCC3, ERCC2
RNA Polymerase I Transcription TerminationR-HSA-738638.033GTF2H5, ERCC3, ERCC2
RNA Polymerase II HIV Promoter EscapeR-HSA-1671627.523GTF2H5, ERCC3, ERCC2
Formation of RNA Pol II elongation complex R-HSA-1123827.563GTF2H5, ERCC3, ERCC2
Formation of HIV elongation complex in the absence of HIV TatR-HSA-1671527.563GTF2H5, ERCC3, ERCC2
Formation of HIV-1 elongation complex containing HIV-1 TatR-HSA-1672007.593GTF2H5, ERCC3, ERCC2
Dual incision reaction in GG-NERR-HSA-739418.593GTF2H5, ERCC3, ERCC2
Formation of the Early Elongation ComplexR-HSA-1134187.943GTF2H5, ERCC3, ERCC2
Gene ExpressionR-HSA-741602.723GTF2H5, ERCC3, ERCC2
RNA Polymerase II Transcription InitiationR-HSA-759537.523GTF2H5, ERCC3, ERCC2
HIV Transcription ElongationR-HSA-1671697.593GTF2H5, ERCC3, ERCC2
Tat-mediated elongation of the HIV-1 transcriptR-HSA-1672467.593GTF2H5, ERCC3, ERCC2
HIV Life CycleR-HSA-1625875.893GTF2H5, ERCC3, ERCC2
RNA Polymerase II Transcription ElongationR-HSA-759557.563GTF2H5, ERCC3, ERCC2

NET-GE enrichment

Term New enriched termICP valueGenes
Global Genomic NER (GG-NER) (R-HSA-109970) -7.890.0GTF2H5, ERCC3, ERCC2
Dual incision reaction in TC-NER (R-HSA-110304) -8.120.0GTF2H5, ERCC3, ERCC2
Formation of transcription-coupled NER (TC-NER) repair complex (R-HSA-110302) -8.120.0GTF2H5, ERCC3, ERCC2
Transcription-coupled NER (TC-NER) (R-HSA-73937) -7.490.0GTF2H5, ERCC3, ERCC2
Formation of incision complex in GG-NER (R-HSA-73935) -8.590.0GTF2H5, ERCC3, ERCC2
RNA Polymerase I Promoter Escape (R-HSA-73772) -8.080.0GTF2H5, ERCC3, ERCC2
RNA Polymerase I Chain Elongation (R-HSA-73777) -7.180.0GTF2H5, ERCC3, ERCC2
RNA Polymerase II Promoter Escape (R-HSA-73776) -7.520.0GTF2H5, ERCC3, ERCC2
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening (R-HSA-73779) -7.520.0GTF2H5, ERCC3, ERCC2
RNA Polymerase I Promoter Clearance (R-HSA-73854) -6.750.0GTF2H5, ERCC3, ERCC2
Disease (R-HSA-1643685) -3.330.046GTF2H5, ERCC3, ERCC2
RNA Polymerase II Transcription (R-HSA-73857) -6.250.0GTF2H5, ERCC3, ERCC2
Transcription of the HIV genome (R-HSA-167172) -6.960.0GTF2H5, ERCC3, ERCC2
Negative epigenetic regulation of rRNA expression (R-HSA-5250941) -6.750.0GTF2H5, ERCC3, ERCC2
RNA Polymerase II Transcription Initiation And Promoter Clearance (R-HSA-76042) -7.520.0GTF2H5, ERCC3, ERCC2
NoRC negatively regulates rRNA expression (R-HSA-427413) -6.810.0GTF2H5, ERCC3, ERCC2
Formation of the HIV-1 Early Elongation Complex (R-HSA-167158) -7.940.0GTF2H5, ERCC3, ERCC2
HIV Infection (R-HSA-162906) -5.220.001GTF2H5, ERCC3, ERCC2
Late Phase of HIV Life Cycle (R-HSA-162599) -6.020.0GTF2H5, ERCC3, ERCC2
Nucleotide Excision Repair (R-HSA-73885) -7.340.0GTF2H5, ERCC3, ERCC2
RNA Polymerase II Pre-transcription Events (R-HSA-674695) -7.010.0GTF2H5, ERCC3, ERCC2
Infectious disease (R-HSA-5663205) -4.470.004GTF2H5, ERCC3, ERCC2
Epigenetic regulation of gene expression (R-HSA-212165) -6.460.0GTF2H5, ERCC3, ERCC2
mRNA Capping (R-HSA-72086) -8.120.0GTF2H5, ERCC3, ERCC2
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription (R-HSA-504046) -6.160.0GTF2H5, ERCC3, ERCC2
RNA Polymerase II Transcription Initiation (R-HSA-75953) -7.520.0GTF2H5, ERCC3, ERCC2
Dual incision reaction in GG-NER (R-HSA-73941) -8.590.0GTF2H5, ERCC3, ERCC2
RNA Polymerase I Transcription Initiation (R-HSA-73762) -7.430.0GTF2H5, ERCC3, ERCC2
RNA Polymerase I Transcription (R-HSA-73864) -6.720.0GTF2H5, ERCC3, ERCC2
HIV Transcription Initiation (R-HSA-167161) -7.520.0GTF2H5, ERCC3, ERCC2
RNA Pol II CTD phosphorylation and interaction with CE (R-HSA-167160) -8.230.0GTF2H5, ERCC3, ERCC2
RNA Polymerase I Transcription Termination (R-HSA-73863) -8.030.0GTF2H5, ERCC3, ERCC2
RNA Polymerase II HIV Promoter Escape (R-HSA-167162) -7.520.0GTF2H5, ERCC3, ERCC2
Formation of RNA Pol II elongation complex (R-HSA-112382) -7.560.0GTF2H5, ERCC3, ERCC2
Formation of HIV elongation complex in the absence of HIV Tat (R-HSA-167152) -7.560.0GTF2H5, ERCC3, ERCC2
Formation of HIV-1 elongation complex containing HIV-1 Tat (R-HSA-167200) -7.590.0GTF2H5, ERCC3, ERCC2
RNA Pol II CTD phosphorylation and interaction with CE (R-HSA-77075) -8.230.0GTF2H5, ERCC3, ERCC2
RNA Polymerase II Transcription Elongation (R-HSA-75955) -7.560.0GTF2H5, ERCC3, ERCC2
DNA Repair (R-HSA-73894) -5.80.0GTF2H5, ERCC3, ERCC2
HIV Transcription Elongation (R-HSA-167169) -7.590.0GTF2H5, ERCC3, ERCC2
Tat-mediated elongation of the HIV-1 transcript (R-HSA-167246) -7.590.0GTF2H5, ERCC3, ERCC2
HIV Life Cycle (R-HSA-162587) -5.890.0GTF2H5, ERCC3, ERCC2
Formation of the Early Elongation Complex (R-HSA-113418) -7.940.0GTF2H5, ERCC3, ERCC2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185RNF113A, GTF2H5, ERCC3, MPLKIP, ERCC2
protein binding (GO:0005515) 0.464RNF113A, ERCC3, MPLKIP, ERCC2
organic cyclic compound binding (GO:0097159) 1.053GTF2H5, ERCC3, ERCC2
heterocyclic compound binding (GO:1901363) 1.063GTF2H5, ERCC3, ERCC2
nucleic acid binding (GO:0003676) 1.443GTF2H5, ERCC3, ERCC2
DNA binding (GO:0003677) 1.923GTF2H5, ERCC3, ERCC2
protein C-terminus binding (GO:0008022) 4.52ERCC3, ERCC2
ATP-dependent helicase activity (GO:0008026) 5.122ERCC3, ERCC2
purine ribonucleoside triphosphate binding (GO:0035639) 2.222ERCC3, ERCC2
protein kinase activity (GO:0004672) 3.272ERCC3, ERCC2
ATPase activity (GO:0016887) 3.652ERCC3, ERCC2
DNA helicase activity (GO:0003678) 5.732ERCC3, ERCC2
RNA polymerase II carboxy-terminal domain kinase activity (GO:0008353) 6.972ERCC3, ERCC2
ion binding (GO:0043167) 1.362RNF113A, ERCC2
nucleoside phosphate binding (GO:1901265) 1.962ERCC3, ERCC2
nucleoside binding (GO:0001882) 2.212ERCC3, ERCC2
cation binding (GO:0043169) 1.42RNF113A, ERCC2
ATPase activity, coupled (GO:0042623) 3.972ERCC3, ERCC2
carbohydrate derivative binding (GO:0097367) 2.032ERCC3, ERCC2
nucleotide binding (GO:0000166) 1.962ERCC3, ERCC2
protein serine/threonine kinase activity (GO:0004674) 3.642ERCC3, ERCC2
transferase activity (GO:0016740) 1.952ERCC3, ERCC2
purine nucleoside binding (GO:0001883) 2.222ERCC3, ERCC2
ribonucleoside binding (GO:0032549) 2.222ERCC3, ERCC2
purine nucleotide binding (GO:0017076) 2.192ERCC3, ERCC2
metal ion binding (GO:0046872) 1.412RNF113A, ERCC2
ATP binding (GO:0005524) 2.432ERCC3, ERCC2
hydrolase activity (GO:0016787) 1.92ERCC3, ERCC2
ATP-dependent DNA helicase activity (GO:0004003) 6.132ERCC3, ERCC2
kinase activity (GO:0016301) 2.932ERCC3, ERCC2
nucleoside-triphosphatase activity (GO:0017111) 3.092ERCC3, ERCC2
helicase activity (GO:0004386) 4.692ERCC3, ERCC2
small molecule binding (GO:0036094) 1.892ERCC3, ERCC2
catalytic activity (GO:0003824) 1.052ERCC3, ERCC2
DNA-dependent ATPase activity (GO:0008094) 5.312ERCC3, ERCC2
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032ERCC3, ERCC2
protein N-terminus binding (GO:0047485) 5.112ERCC3, ERCC2
adenyl nucleotide binding (GO:0030554) 2.42ERCC3, ERCC2
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082ERCC3, ERCC2
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772ERCC3, ERCC2
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032ERCC3, ERCC2
pyrophosphatase activity (GO:0016462) 3.042ERCC3, ERCC2
adenyl ribonucleotide binding (GO:0032559) 2.412ERCC3, ERCC2
purine NTP-dependent helicase activity (GO:0070035) 5.122ERCC3, ERCC2
purine ribonucleotide binding (GO:0032555) 2.22ERCC3, ERCC2
purine ribonucleoside binding (GO:0032550) 2.222ERCC3, ERCC2
ribonucleotide binding (GO:0032553) 2.192ERCC3, ERCC2

NET-GE enrichment

Term New enriched termICP valueGenes
DNA-dependent ATPase activity (GO:0008094) -5.310.01ERCC3, ERCC2
ATP-dependent helicase activity (GO:0008026) -5.120.016ERCC3, ERCC2
protein N-terminus binding (GO:0047485) -5.110.016ERCC3, ERCC2
ATP-dependent DNA helicase activity (GO:0004003) -6.130.002ERCC3, ERCC2
purine NTP-dependent helicase activity (GO:0070035) -5.120.016ERCC3, ERCC2
DNA helicase activity (GO:0003678) -5.730.004ERCC3, ERCC2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.265RNF113A, GTF2H5, ERCC3, MPLKIP, ERCC2
RNA metabolic process (GO:0016070) 1.594RNF113A, GTF2H5, ERCC3, ERCC2
mRNA metabolic process (GO:0016071) 3.334RNF113A, GTF2H5, ERCC3, ERCC2
primary metabolic process (GO:0044238) 0.694RNF113A, GTF2H5, ERCC3, ERCC2
organelle organization (GO:0006996) 2.024GTF2H5, ERCC3, MPLKIP, ERCC2
cellular macromolecule metabolic process (GO:0044260) 0.934RNF113A, GTF2H5, ERCC3, ERCC2
nucleobase-containing compound metabolic process (GO:0006139) 1.354RNF113A, GTF2H5, ERCC3, ERCC2
cellular metabolic process (GO:0044237) 0.694RNF113A, GTF2H5, ERCC3, ERCC2
cellular aromatic compound metabolic process (GO:0006725) 1.34RNF113A, GTF2H5, ERCC3, ERCC2
cellular component organization (GO:0016043) 1.244GTF2H5, ERCC3, MPLKIP, ERCC2
macromolecule metabolic process (GO:0043170) 0.834RNF113A, GTF2H5, ERCC3, ERCC2
nucleic acid metabolic process (GO:0090304) 1.464RNF113A, GTF2H5, ERCC3, ERCC2
organic substance metabolic process (GO:0071704) 0.634RNF113A, GTF2H5, ERCC3, ERCC2
cellular nitrogen compound metabolic process (GO:0034641) 1.224RNF113A, GTF2H5, ERCC3, ERCC2
nitrogen compound metabolic process (GO:0006807) 1.134RNF113A, GTF2H5, ERCC3, ERCC2
organic cyclic compound metabolic process (GO:1901360) 1.264RNF113A, GTF2H5, ERCC3, ERCC2
metabolic process (GO:0008152) 0.584RNF113A, GTF2H5, ERCC3, ERCC2
mRNA processing (GO:0006397) 3.694RNF113A, GTF2H5, ERCC3, ERCC2
RNA processing (GO:0006396) 3.014RNF113A, GTF2H5, ERCC3, ERCC2
cellular component organization or biogenesis (GO:0071840) 1.224GTF2H5, ERCC3, MPLKIP, ERCC2
heterocycle metabolic process (GO:0046483) 1.314RNF113A, GTF2H5, ERCC3, ERCC2
DNA conformation change (GO:0071103) 4.93GTF2H5, ERCC3, ERCC2
nucleotide-excision repair, preincision complex assembly (GO:0006294) 6.363GTF2H5, ERCC3, ERCC2
nucleotide-excision repair, DNA incision, 5'-to lesion (GO:0006296) 6.123GTF2H5, ERCC3, ERCC2
regulation of primary metabolic process (GO:0080090) 1.083GTF2H5, ERCC3, ERCC2
regulation of metabolic process (GO:0019222) 1.023GTF2H5, ERCC3, ERCC2
RNA capping (GO:0036260) 6.23GTF2H5, ERCC3, ERCC2
macromolecular complex subunit organization (GO:0043933) 2.143GTF2H5, ERCC3, ERCC2
response to radiation (GO:0009314) 3.693GTF2H5, ERCC3, ERCC2
cellular macromolecular complex assembly (GO:0034622) 3.183GTF2H5, ERCC3, ERCC2
7-methylguanosine RNA capping (GO:0009452) 6.23GTF2H5, ERCC3, ERCC2
regulation of cellular biosynthetic process (GO:0031326) 1.383GTF2H5, ERCC3, ERCC2
regulation of cellular component organization (GO:0051128) 2.013GTF2H5, ERCC3, ERCC2
cellular biosynthetic process (GO:0044249) 1.373GTF2H5, ERCC3, ERCC2
cellular component assembly (GO:0022607) 2.143GTF2H5, ERCC3, ERCC2
global genome nucleotide-excision repair (GO:0070911) 6.263GTF2H5, ERCC3, ERCC2
DNA-templated transcription, initiation (GO:0006352) 4.493GTF2H5, ERCC3, ERCC2
positive regulation of protein complex assembly (GO:0031334) 4.443GTF2H5, ERCC3, ERCC2
organic substance biosynthetic process (GO:1901576) 1.343GTF2H5, ERCC3, ERCC2
nucleotide-excision repair, DNA incision, 3'-to lesion (GO:0006295) 6.683GTF2H5, ERCC3, ERCC2
organic cyclic compound biosynthetic process (GO:1901362) 1.663GTF2H5, ERCC3, ERCC2
regulation of biological process (GO:0050789) 0.453GTF2H5, ERCC3, ERCC2
nucleic acid-templated transcription (GO:0097659) 1.913GTF2H5, ERCC3, ERCC2
RNA biosynthetic process (GO:0032774) 1.843GTF2H5, ERCC3, ERCC2
protein-DNA complex subunit organization (GO:0071824) 4.453GTF2H5, ERCC3, ERCC2
macromolecular complex assembly (GO:0065003) 2.553GTF2H5, ERCC3, ERCC2
cellular response to stimulus (GO:0051716) 1.973GTF2H5, ERCC3, ERCC2
nucleotide-excision repair, preincision complex stabilization (GO:0006293) 6.683GTF2H5, ERCC3, ERCC2
regulation of cellular component biogenesis (GO:0044087) 3.083GTF2H5, ERCC3, ERCC2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463GTF2H5, ERCC3, ERCC2
nucleotide-excision repair, DNA incision (GO:0033683) 6.073GTF2H5, ERCC3, ERCC2
transcription initiation from RNA polymerase I promoter (GO:0006361) 6.233GTF2H5, ERCC3, ERCC2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433GTF2H5, ERCC3, ERCC2
termination of RNA polymerase I transcription (GO:0006363) 6.293GTF2H5, ERCC3, ERCC2
transcription elongation from RNA polymerase I promoter (GO:0006362) 6.333GTF2H5, ERCC3, ERCC2
biological regulation (GO:0065007) 0.393GTF2H5, ERCC3, ERCC2
single-organism process (GO:0044699) 0.483ERCC3, MPLKIP, ERCC2
transcription initiation from RNA polymerase II promoter (GO:0006367) 4.73GTF2H5, ERCC3, ERCC2
transcription from RNA polymerase II promoter (GO:0006366) 3.383GTF2H5, ERCC3, ERCC2
positive regulation of biological process (GO:0048518) 1.23GTF2H5, ERCC3, ERCC2
transcription elongation from RNA polymerase II promoter (GO:0006368) 5.323GTF2H5, ERCC3, ERCC2
regulation of gene expression (GO:0010468) 1.373GTF2H5, ERCC3, ERCC2
heterocycle biosynthetic process (GO:0018130) 1.73GTF2H5, ERCC3, ERCC2
positive regulation of cellular component organization (GO:0051130) 2.683GTF2H5, ERCC3, ERCC2
DNA geometric change (GO:0032392) 5.313GTF2H5, ERCC3, ERCC2
transcription-coupled nucleotide-excision repair (GO:0006283) 5.443GTF2H5, ERCC3, ERCC2
biosynthetic process (GO:0009058) 1.323GTF2H5, ERCC3, ERCC2
DNA repair (GO:0006281) 3.593GTF2H5, ERCC3, ERCC2
regulation of macromolecule metabolic process (GO:0060255) 1.083GTF2H5, ERCC3, ERCC2
regulation of cellular metabolic process (GO:0031323) 1.073GTF2H5, ERCC3, ERCC2
DNA duplex unwinding (GO:0032508) 5.373GTF2H5, ERCC3, ERCC2
protein-DNA complex assembly (GO:0065004) 4.63GTF2H5, ERCC3, ERCC2
regulation of biosynthetic process (GO:0009889) 1.373GTF2H5, ERCC3, ERCC2
regulation of nucleic acid-templated transcription (GO:1903506) 1.553GTF2H5, ERCC3, ERCC2
nucleotide-excision repair (GO:0006289) 5.053GTF2H5, ERCC3, ERCC2
cellular macromolecule biosynthetic process (GO:0034645) 1.663GTF2H5, ERCC3, ERCC2
response to stress (GO:0006950) 1.83GTF2H5, ERCC3, ERCC2
macromolecule biosynthetic process (GO:0009059) 1.613GTF2H5, ERCC3, ERCC2
single-organism cellular process (GO:0044763) 0.653ERCC3, MPLKIP, ERCC2
regulation of nitrogen compound metabolic process (GO:0051171) 1.363GTF2H5, ERCC3, ERCC2
regulation of RNA biosynthetic process (GO:2001141) 1.553GTF2H5, ERCC3, ERCC2
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723GTF2H5, ERCC3, ERCC2
regulation of protein complex assembly (GO:0043254) 3.833GTF2H5, ERCC3, ERCC2
regulation of cellular process (GO:0050794) 0.53GTF2H5, ERCC3, ERCC2
response to abiotic stimulus (GO:0009628) 2.83GTF2H5, ERCC3, ERCC2
cellular response to DNA damage stimulus (GO:0006974) 3.173GTF2H5, ERCC3, ERCC2
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593GTF2H5, ERCC3, ERCC2
chromosome organization (GO:0051276) 3.793GTF2H5, ERCC3, ERCC2
nucleic acid phosphodiester bond hydrolysis (GO:0090305) 4.123GTF2H5, ERCC3, ERCC2
response to stimulus (GO:0050896) 1.223GTF2H5, ERCC3, ERCC2
regulation of RNA metabolic process (GO:0051252) 1.523GTF2H5, ERCC3, ERCC2
nucleotide-excision repair, DNA duplex unwinding (GO:0000717) 6.643GTF2H5, ERCC3, ERCC2
DNA-templated transcription, elongation (GO:0006354) 5.153GTF2H5, ERCC3, ERCC2
regulation of transcription, DNA-templated (GO:0006355) 1.563GTF2H5, ERCC3, ERCC2
7-methylguanosine mRNA capping (GO:0006370) 6.233GTF2H5, ERCC3, ERCC2
regulation of macromolecule biosynthetic process (GO:0010556) 1.433GTF2H5, ERCC3, ERCC2
transcription, DNA-templated (GO:0006351) 1.913GTF2H5, ERCC3, ERCC2
cellular response to stress (GO:0033554) 2.513GTF2H5, ERCC3, ERCC2
DNA-templated transcription, termination (GO:0006353) 5.123GTF2H5, ERCC3, ERCC2
DNA metabolic process (GO:0006259) 3.093GTF2H5, ERCC3, ERCC2
aromatic compound biosynthetic process (GO:0019438) 1.73GTF2H5, ERCC3, ERCC2
positive regulation of cellular component biogenesis (GO:0044089) 3.713GTF2H5, ERCC3, ERCC2
positive regulation of cellular process (GO:0048522) 1.33GTF2H5, ERCC3, ERCC2
developmental process (GO:0032502) 1.362ERCC3, ERCC2
anatomical structure development (GO:0048856) 1.582ERCC3, ERCC2
positive regulation of metabolic process (GO:0009893) 1.742ERCC3, ERCC2
positive regulation of biosynthetic process (GO:0009891) 2.292ERCC3, ERCC2
phosphorylation (GO:0016310) 2.632ERCC3, ERCC2
positive regulation of cellular metabolic process (GO:0031325) 1.812ERCC3, ERCC2
cell differentiation (GO:0030154) 2.142ERCC3, ERCC2
response to UV (GO:0009411) 4.882ERCC3, ERCC2
response to light stimulus (GO:0009416) 4.082ERCC3, ERCC2
regulation of mitotic cell cycle phase transition (GO:1901990) 4.232ERCC3, ERCC2
UV protection (GO:0009650) 7.242ERCC3, ERCC2
ncRNA metabolic process (GO:0034660) 3.442RNF113A, GTF2H5
cell death (GO:0008219) 3.052ERCC3, ERCC2
response to hypoxia (GO:0001666) 4.132ERCC3, ERCC2
cell division (GO:0051301) 3.682MPLKIP, ERCC2
hair cell differentiation (GO:0035315) 7.022ERCC3, ERCC2
cellular protein metabolic process (GO:0044267) 1.632ERCC3, ERCC2
regulation of mitotic cell cycle (GO:0007346) 3.712ERCC3, ERCC2
positive regulation of macromolecule metabolic process (GO:0010604) 1.812ERCC3, ERCC2
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242ERCC3, ERCC2
cellular developmental process (GO:0048869) 1.822ERCC3, ERCC2
positive regulation of cellular biosynthetic process (GO:0031328) 2.32ERCC3, ERCC2
regulation of cell cycle process (GO:0010564) 3.52ERCC3, ERCC2
phosphate-containing compound metabolic process (GO:0006796) 2.162ERCC3, ERCC2
interspecies interaction between organisms (GO:0044419) 3.082ERCC3, ERCC2
animal organ development (GO:0048513) 2.532ERCC3, ERCC2
epithelial cell differentiation (GO:0030855) 3.982ERCC3, ERCC2
response to oxygen levels (GO:0070482) 4.022ERCC3, ERCC2
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562ERCC3, ERCC2
protein phosphorylation (GO:0006468) 2.892ERCC3, ERCC2
ncRNA processing (GO:0034470) 3.772RNF113A, GTF2H5
neuron differentiation (GO:0030182) 4.172ERCC3, ERCC2
apoptotic process (GO:0006915) 3.142ERCC3, ERCC2
cellular protein modification process (GO:0006464) 1.792ERCC3, ERCC2
single-organism developmental process (GO:0044767) 1.492ERCC3, ERCC2
programmed cell death (GO:0012501) 3.12ERCC3, ERCC2
macromolecule modification (GO:0043412) 1.732ERCC3, ERCC2
protein modification process (GO:0036211) 1.792ERCC3, ERCC2
positive regulation of transcription, DNA-templated (GO:0045893) 2.562ERCC3, ERCC2
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292ERCC3, ERCC2
multi-organism cellular process (GO:0044764) 3.142ERCC3, ERCC2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352ERCC3, ERCC2
response to oxidative stress (GO:0006979) 3.92ERCC3, ERCC2
multi-organism process (GO:0051704) 2.652ERCC3, ERCC2
regulation of cell cycle phase transition (GO:1901987) 4.152ERCC3, ERCC2
protein metabolic process (GO:0019538) 1.452ERCC3, ERCC2
response to decreased oxygen levels (GO:0036293) 4.092ERCC3, ERCC2
regulation of cell cycle (GO:0051726) 2.932ERCC3, ERCC2
positive regulation of RNA metabolic process (GO:0051254) 2.512ERCC3, ERCC2
positive regulation of RNA biosynthetic process (GO:1902680) 2.542ERCC3, ERCC2
epidermal cell differentiation (GO:0009913) 5.132ERCC3, ERCC2
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392ERCC3, ERCC2
positive regulation of gene expression (GO:0010628) 2.352ERCC3, ERCC2
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812ERCC3, ERCC2
viral process (GO:0016032) 3.152ERCC3, ERCC2
phosphorus metabolic process (GO:0006793) 2.152ERCC3, ERCC2
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152ERCC3, ERCC2

NET-GE enrichment

Term New enriched termICP valueGenes
RNA capping (GO:0036260) -6.20.014ERCC3, ERCC2
response to radiation (GO:0009314) -3.690.015GTF2H5, ERCC3, ERCC2
7-methylguanosine RNA capping (GO:0009452) -6.20.014ERCC3, ERCC2
UV protection (GO:0009650) -7.240.003ERCC3, ERCC2
positive regulation of viral transcription (GO:0050434) NEW6.070.014ERCC3, ERCC2
hair cell differentiation (GO:0035315) -7.020.001ERCC3, ERCC2
DNA excision (GO:0044349) NEW9.730.007ERCC3, ERCC2
nucleotide-excision repair, DNA incision (GO:0033683) -6.070.0ERCC3, ERCC2
transcription initiation from RNA polymerase I promoter (GO:0006361) -6.230.009ERCC3, ERCC2
transcription from RNA polymerase I promoter (GO:0006360) NEW8.120.016ERCC3, ERCC2
termination of RNA polymerase I transcription (GO:0006363) -6.290.003ERCC3, ERCC2
transcription elongation from RNA polymerase I promoter (GO:0006362) -6.330.0GTF2H5, ERCC3, ERCC2
regulation of viral transcription (GO:0046782) NEW5.620.029ERCC3, ERCC2
transcription elongation from RNA polymerase II promoter (GO:0006368) -5.320.023ERCC3, ERCC2
DNA geometric change (GO:0032392) -5.310.017ERCC3, ERCC2
transcription-coupled nucleotide-excision repair (GO:0006283) -5.440.039ERCC3, ERCC2
DNA repair (GO:0006281) -3.590.013GTF2H5, ERCC3, ERCC2
DNA duplex unwinding (GO:0032508) -5.370.016ERCC3, ERCC2
nucleotide-excision repair (GO:0006289) -5.050.0GTF2H5, ERCC3, ERCC2
positive regulation of multi-organism process (GO:0043902) NEW4.680.042ERCC3, ERCC2
nucleotide-excision repair, DNA damage removal (GO:0000718) NEW9.730.007ERCC3, ERCC2
epidermal cell differentiation (GO:0009913) -5.130.029ERCC3, ERCC2
DNA-templated transcription, elongation (GO:0006354) -5.150.0GTF2H5, ERCC3, ERCC2
7-methylguanosine mRNA capping (GO:0006370) -6.230.005ERCC3, ERCC2
DNA-templated transcription, termination (GO:0006353) -5.120.036ERCC3, ERCC2
positive regulation of viral process (GO:0048524) NEW5.110.032ERCC3, ERCC2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular organelle part (GO:0044446) 0.815RNF113A, GTF2H5, ERCC3, MPLKIP, ERCC2
nuclear part (GO:0044428) 1.555RNF113A, GTF2H5, ERCC3, MPLKIP, ERCC2
intracellular part (GO:0044424) 0.285RNF113A, GTF2H5, ERCC3, MPLKIP, ERCC2
cell part (GO:0044464) 0.115RNF113A, GTF2H5, ERCC3, MPLKIP, ERCC2
organelle part (GO:0044422) 0.795RNF113A, GTF2H5, ERCC3, MPLKIP, ERCC2
macromolecular complex (GO:0032991) 1.354RNF113A, GTF2H5, ERCC3, ERCC2
intracellular membrane-bounded organelle (GO:0043231) 0.64GTF2H5, ERCC3, MPLKIP, ERCC2
nucleus (GO:0005634) 1.074GTF2H5, ERCC3, MPLKIP, ERCC2
nucleoplasm (GO:0005654) 1.894GTF2H5, ERCC3, MPLKIP, ERCC2
intracellular organelle (GO:0043229) 0.514GTF2H5, ERCC3, MPLKIP, ERCC2
membrane-bounded organelle (GO:0043227) 0.474GTF2H5, ERCC3, MPLKIP, ERCC2
organelle (GO:0043226) 0.44GTF2H5, ERCC3, MPLKIP, ERCC2
protein complex (GO:0043234) 1.513GTF2H5, ERCC3, ERCC2
core TFIIH complex (GO:0000439) 7.723GTF2H5, ERCC3, ERCC2
non-membrane-bounded organelle (GO:0043228) 1.763GTF2H5, MPLKIP, ERCC2
intracellular non-membrane-bounded organelle (GO:0043232) 1.763GTF2H5, MPLKIP, ERCC2
cytoskeleton (GO:0005856) 2.552MPLKIP, ERCC2
carboxy-terminal domain protein kinase complex (GO:0032806) 6.712ERCC3, ERCC2
catalytic complex (GO:1902494) 2.92ERCC3, ERCC2
transferase complex, transferring phosphorus-containing groups (GO:0061695) 4.612ERCC3, ERCC2
protein kinase complex (GO:1902911) 5.312ERCC3, ERCC2
serine/threonine protein kinase complex (GO:1902554) 5.452ERCC3, ERCC2
nuclear transcription factor complex (GO:0044798) 4.952ERCC3, ERCC2
cytoplasm (GO:0005737) 1.012MPLKIP, ERCC2
RNA polymerase II transcription factor complex (GO:0090575) 5.182ERCC3, ERCC2
cytoskeletal part (GO:0044430) 2.492MPLKIP, ERCC2
nucleoplasm part (GO:0044451) 3.222ERCC3, ERCC2
transcription factor complex (GO:0005667) 4.12ERCC3, ERCC2
transferase complex (GO:1990234) 3.322ERCC3, ERCC2
holo TFIIH complex (GO:0005675) 7.322ERCC3, ERCC2

NET-GE enrichment

Term New enriched termICP valueGenes
carboxy-terminal domain protein kinase complex (GO:0032806) -6.710.0ERCC3, ERCC2
protein kinase complex (GO:1902911) -5.310.034ERCC3, ERCC2
serine/threonine protein kinase complex (GO:1902554) -5.450.017ERCC3, ERCC2
nuclear transcription factor complex (GO:0044798) -4.950.023ERCC3, ERCC2
RNA polymerase II transcription factor complex (GO:0090575) -5.180.002ERCC3, ERCC2
transcription factor complex (GO:0005667) -4.10.041ERCC3, ERCC2
holo TFIIH complex (GO:0005675) -7.320.0ERCC3, ERCC2