Disease table of CEREBROOCULOFACIOSKELETAL SYNDROME OMIM ID: PS214150

Gene-disease associations table

GeneAssociated with CEREBROOCULOFACIOSKELETAL SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ERCC1ClinVar, OMIM, HUMSAVARHGNC link19q13.321PS214150
ERCC2ClinVar, OMIM, HUMSAVARHGNC link19q13.323278730, PS601675, PS214150
ERCC5ClinVar, OMIMHGNC link13q33.12PS214150, 278780
ERCC6ClinVar, OMIM, HUMSAVARHGNC link10q11.236211980, PS603075, 133540, PS600630, PS214150, 278800

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
19q13.322ERCC2, ERCC1
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
19q132ERCC2, ERCC1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
19q12ERCC2, ERCC1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
19q2ERCC2, ERCC1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
192ERCC2, ERCC1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
ERCC2YES5LAMTOR5, CDKN1A, BAX, TP53, BCL20
E2F1NO123WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B2ERCC1, ERCC5
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
ERCC1YES3ZNRD1, KAT5, E2F10
ERCC2YES1HIF1A0
ERCC5YES3YY1, E2F1, CEBPG0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ERCC1ERCC2No3ACAT1, GTF2H1, TOPBP1
ERCC1ERCC5No3GTF2H1, TAF10, POLR2A
ERCC1ERCC6No3POLR2A, ERCC4, XPA
ERCC2ERCC5Yes7GTF2H1, CCNH, GTF2H5, PIDD1, ERCC6, CDK7, ERCC3
ERCC2ERCC6Yes3ERCC5, ERCC3, TP53
ERCC5ERCC6Yes4POLR2A, ERCC3, ERCC2, PCNA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
ERCC1ERCC2Yesbinding41TBP, POLR2J, MNAT1, XAB2, POLR2I, RPA1, ERCC6, POLR2H, RPA3, XPA, POLD1, TAF12, FEN1, MSH2, TCEA1, POLR2C, DDB1, POLR2F, POLR2D, ERCC8, RAD23B, CCNH, REV3L, ERCC5, SUPT4H1, TAF6, RPA2, POLR2L, XPC, ERCC3, POLR2G, DDB2, POLR2B, TAF10, POLR2K, ERCC4, POLR2A, UBC, POLR2E, GTF2H1, GTF2H3
ERCC1ERCC5Yesbinding40ERCC2, POLR2K, POLR2J, MNAT1, XAB2, FANCM, RPA1, ERCC6, POLR2F, POLR2H, XPA, POLD1, MLH1, TCEA1, POLR2C, DDB1, POLR2D, ERCC8, RAD23B, CCNH, RPA2, POLR2L, GTF2H1, MSH6, ERCC3, POLR2G, DDB2, POLR2B, XPC, PMS2, MUS81, POLR2I, ERCC4, POLR2A, RPA3, UBC, POLR2E, MSH2, GTF2H3, PMS1
ERCC1ERCC6Yesbinding28ERCC2, TBP, POLR2J, XAB2, POLR2I, CCNH, POLR2F, POLR2H, XPA, GTF2H1, TCEA1, POLR2C, DDB1, POLR2E, POLR2D, ERCC8, ERCC5, POLR2L, SUPT4H1, ERCC3, MNAT1, POLR2B, POLR2K, ERCC4, POLR2A, UBC, POLR2G, GTF2H3
ERCC2ERCC5Yesbinding34POLR2J, MNAT1, XAB2, POLR2I, RPA1, ERCC6, POLR2F, POLR2C, POLR2H, XPA, POLD1, MSH2, TCEA1, POLR2D, DDB1, POLR2B, ERCC8, RAD23B, CCNH, ERCC1, RPA2, POLR2L, XPC, ERCC3, POLR2G, DDB2, POLR2K, ERCC4, POLR2A, RPA3, UBC, POLR2E, GTF2H1, GTF2H3
ERCC2ERCC6Yesbinding42ERCC5, UBTF, TBP, POLR2J, CCNT1, MNAT1, TP53, POLR2I, ERCC4, POLR2F, POLR2H, XPA, GTF2H1, TCEA1, POLR2C, DDB1, POLR2D, ERCC8, CCNH, TAF1D, CDK9, ERCC1, TAF1C, TH1L, TAF1A, POLR2L, XAB2, POLR1A, SUPT4H1, ERCC3, POLR2E, POLR2B, COBRA1, TAF1B, SUPT5H, POLR2K, TTF1, POLR2A, UBC, POLR2G, WHSC2, GTF2H3
ERCC5ERCC6Yesbinding27ERCC2, POLR2J, XAB2, POLR2I, CCNH, POLR2H, POLR2F, XPA, GTF2H1, TCEA1, POLR2C, DDB1, POLR2E, POLR2D, ERCC8, ERCC1, POLR2L, PCNA, ERCC3, MNAT1, POLR2B, POLR2K, ERCC4, POLR2A, UBC, POLR2G, GTF2H3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Nucleotide excision repairhsa034207.154ERCC1, ERCC5, ERCC6, ERCC2

NET-GE enrichment

Term New enriched termICP valueGenes
Nucleotide excision repair (hsa03420) -7.150.0ERCC1, ERCC5, ERCC6, ERCC2
Genetic Information ProcessingNEW2.480.007ERCC1, ERCC5, ERCC6, ERCC2
Replication and repairNEW5.410.0ERCC1, ERCC5, ERCC6, ERCC2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Transcription-coupled NER (TC-NER)R-HSA-739377.494ERCC1, ERCC5, ERCC6, ERCC2
DNA RepairR-HSA-738945.84ERCC1, ERCC5, ERCC6, ERCC2
Nucleotide Excision RepairR-HSA-738857.344ERCC1, ERCC5, ERCC6, ERCC2
Dual incision reaction in TC-NERR-HSA-1103048.124ERCC1, ERCC5, ERCC6, ERCC2
Formation of transcription-coupled NER (TC-NER) repair complexR-HSA-1103028.124ERCC1, ERCC5, ERCC6, ERCC2
Global Genomic NER (GG-NER)R-HSA-1099707.893ERCC1, ERCC5, ERCC2
Dual incision reaction in GG-NERR-HSA-739418.593ERCC1, ERCC5, ERCC2
Formation of incision complex in GG-NERR-HSA-739358.593ERCC1, ERCC5, ERCC2
RNA Polymerase I Transcription InitiationR-HSA-737627.432ERCC6, ERCC2
RNA Polymerase I Promoter ClearanceR-HSA-738546.752ERCC6, ERCC2
Gene ExpressionR-HSA-741602.722ERCC6, ERCC2
RNA Polymerase I TranscriptionR-HSA-738646.722ERCC6, ERCC2
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionR-HSA-5040466.162ERCC6, ERCC2

NET-GE enrichment

Term New enriched termICP valueGenes
Negative epigenetic regulation of rRNA expression (R-HSA-5250941) NEW6.750.044ERCC6, ERCC2
Global Genomic NER (GG-NER) (R-HSA-109970) -7.890.0ERCC1, ERCC5, ERCC2
NoRC negatively regulates rRNA expression (R-HSA-427413) NEW6.810.04ERCC6, ERCC2
Dual incision reaction in TC-NER (R-HSA-110304) -8.120.0ERCC1, ERCC5, ERCC6, ERCC2
Formation of transcription-coupled NER (TC-NER) repair complex (R-HSA-110302) -8.120.0ERCC1, ERCC5, ERCC6, ERCC2
Transcription-coupled NER (TC-NER) (R-HSA-73937) -7.490.0ERCC1, ERCC5, ERCC6, ERCC2
Formation of incision complex in GG-NER (R-HSA-73935) -8.590.0ERCC1, ERCC5, ERCC2
Dual incision reaction in GG-NER (R-HSA-73941) -8.590.0ERCC1, ERCC5, ERCC2
RNA Polymerase I Transcription Initiation (R-HSA-73762) -7.430.009ERCC6, ERCC2
RNA Polymerase I Chain Elongation (R-HSA-73777) NEW7.180.019ERCC6, ERCC2
DNA Repair (R-HSA-73894) -5.80.0ERCC1, ERCC5, ERCC6, ERCC2
RNA Polymerase I Transcription (R-HSA-73864) -6.720.025ERCC6, ERCC2
Nucleotide Excision Repair (R-HSA-73885) -7.340.0ERCC1, ERCC5, ERCC6, ERCC2
RNA Polymerase I Promoter Clearance (R-HSA-73854) -6.750.024ERCC6, ERCC2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
hydrolase activity (GO:0016787) 1.94ERCC1, ERCC5, ERCC6, ERCC2
protein binding (GO:0005515) 0.464ERCC1, ERCC5, ERCC6, ERCC2
organic cyclic compound binding (GO:0097159) 1.054ERCC1, ERCC5, ERCC6, ERCC2
catalytic activity (GO:0003824) 1.054ERCC1, ERCC5, ERCC6, ERCC2
binding (GO:0005488) 0.184ERCC1, ERCC5, ERCC6, ERCC2
nucleic acid binding (GO:0003676) 1.444ERCC1, ERCC5, ERCC6, ERCC2
DNA binding (GO:0003677) 1.924ERCC1, ERCC5, ERCC6, ERCC2
heterocyclic compound binding (GO:1901363) 1.064ERCC1, ERCC5, ERCC6, ERCC2
protein C-terminus binding (GO:0008022) 4.53ERCC1, ERCC6, ERCC2
protein N-terminus binding (GO:0047485) 5.113ERCC5, ERCC6, ERCC2
purine ribonucleoside triphosphate binding (GO:0035639) 2.222ERCC6, ERCC2
deoxyribonuclease activity (GO:0004536) 5.482ERCC1, ERCC5
ATPase activity (GO:0016887) 3.652ERCC6, ERCC2
DNA helicase activity (GO:0003678) 5.732ERCC6, ERCC2
ion binding (GO:0043167) 1.362ERCC5, ERCC2
purine nucleoside binding (GO:0001883) 2.222ERCC6, ERCC2
nucleoside binding (GO:0001882) 2.212ERCC6, ERCC2
cation binding (GO:0043169) 1.42ERCC5, ERCC2
structure-specific DNA binding (GO:0043566) 4.982ERCC1, ERCC5
ATPase activity, coupled (GO:0042623) 3.972ERCC6, ERCC2
endodeoxyribonuclease activity (GO:0004520) 5.812ERCC1, ERCC5
nucleotide binding (GO:0000166) 1.962ERCC6, ERCC2
nucleoside phosphate binding (GO:1901265) 1.962ERCC6, ERCC2
ribonucleoside binding (GO:0032549) 2.222ERCC6, ERCC2
purine nucleotide binding (GO:0017076) 2.192ERCC6, ERCC2
metal ion binding (GO:0046872) 1.412ERCC5, ERCC2
single-stranded DNA binding (GO:0003697) 5.172ERCC1, ERCC5
ATP binding (GO:0005524) 2.432ERCC6, ERCC2
nucleoside-triphosphatase activity (GO:0017111) 3.092ERCC6, ERCC2
hydrolase activity, acting on ester bonds (GO:0016788) 3.12ERCC1, ERCC5
helicase activity (GO:0004386) 4.692ERCC6, ERCC2
small molecule binding (GO:0036094) 1.892ERCC6, ERCC2
nuclease activity (GO:0004518) 4.332ERCC1, ERCC5
DNA-dependent ATPase activity (GO:0008094) 5.312ERCC6, ERCC2
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032ERCC6, ERCC2
adenyl nucleotide binding (GO:0030554) 2.42ERCC6, ERCC2
carbohydrate derivative binding (GO:0097367) 2.032ERCC6, ERCC2
endonuclease activity (GO:0004519) 4.782ERCC1, ERCC5
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032ERCC6, ERCC2
pyrophosphatase activity (GO:0016462) 3.042ERCC6, ERCC2
adenyl ribonucleotide binding (GO:0032559) 2.412ERCC6, ERCC2
purine ribonucleotide binding (GO:0032555) 2.22ERCC6, ERCC2
purine ribonucleoside binding (GO:0032550) 2.222ERCC6, ERCC2
ribonucleotide binding (GO:0032553) 2.192ERCC6, ERCC2

NET-GE enrichment

Term New enriched termICP valueGenes
hydrolase activity (GO:0016787) -1.90.037ERCC1, ERCC5, ERCC6, ERCC2
protein C-terminus binding (GO:0008022) -4.50.0ERCC1, ERCC6, ERCC2
protein N-terminus binding (GO:0047485) -5.110.001ERCC5, ERCC6, ERCC2
ATPase activity, coupled (GO:0042623) -3.970.01ERCC5, ERCC6, ERCC2
deoxyribonuclease activity (GO:0004536) -5.480.021ERCC1, ERCC5
endonuclease activity (GO:0004519) -4.780.02ERCC1, ERCC5
DNA-dependent ATPase activity (GO:0008094) -5.310.006ERCC6, ERCC2
endodeoxyribonuclease activity (GO:0004520) -5.810.009ERCC1, ERCC5
ATPase activity (GO:0016887) -3.650.03ERCC5, ERCC6, ERCC2
DNA binding (GO:0003677) -1.920.029ERCC1, ERCC5, ERCC6, ERCC2
single-stranded DNA binding (GO:0003697) -5.170.03ERCC1, ERCC5
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
response to abiotic stimulus (GO:0009628) 2.84ERCC1, ERCC5, ERCC6, ERCC2
response to radiation (GO:0009314) 3.694ERCC1, ERCC5, ERCC6, ERCC2
nucleic acid metabolic process (GO:0090304) 1.464ERCC1, ERCC5, ERCC6, ERCC2
cellular nitrogen compound metabolic process (GO:0034641) 1.224ERCC1, ERCC5, ERCC6, ERCC2
nitrogen compound metabolic process (GO:0006807) 1.134ERCC1, ERCC5, ERCC6, ERCC2
response to light stimulus (GO:0009416) 4.084ERCC1, ERCC5, ERCC6, ERCC2
regulation of biological process (GO:0050789) 0.454ERCC1, ERCC5, ERCC6, ERCC2
organic cyclic compound metabolic process (GO:1901360) 1.264ERCC1, ERCC5, ERCC6, ERCC2
nucleobase-containing compound metabolic process (GO:0006139) 1.354ERCC1, ERCC5, ERCC6, ERCC2
cellular response to stimulus (GO:0051716) 1.974ERCC1, ERCC5, ERCC6, ERCC2
cellular macromolecule metabolic process (GO:0044260) 0.934ERCC1, ERCC5, ERCC6, ERCC2
organic substance metabolic process (GO:0071704) 0.634ERCC1, ERCC5, ERCC6, ERCC2
biological regulation (GO:0065007) 0.394ERCC1, ERCC5, ERCC6, ERCC2
positive regulation of biological process (GO:0048518) 1.24ERCC1, ERCC5, ERCC6, ERCC2
transcription-coupled nucleotide-excision repair (GO:0006283) 5.444ERCC1, ERCC5, ERCC6, ERCC2
DNA repair (GO:0006281) 3.594ERCC1, ERCC5, ERCC6, ERCC2
cellular process (GO:0009987) 0.264ERCC1, ERCC5, ERCC6, ERCC2
cellular aromatic compound metabolic process (GO:0006725) 1.34ERCC1, ERCC5, ERCC6, ERCC2
nucleotide-excision repair (GO:0006289) 5.054ERCC1, ERCC5, ERCC6, ERCC2
cellular response to DNA damage stimulus (GO:0006974) 3.174ERCC1, ERCC5, ERCC6, ERCC2
response to stress (GO:0006950) 1.84ERCC1, ERCC5, ERCC6, ERCC2
metabolic process (GO:0008152) 0.584ERCC1, ERCC5, ERCC6, ERCC2
regulation of cellular process (GO:0050794) 0.54ERCC1, ERCC5, ERCC6, ERCC2
heterocycle metabolic process (GO:0046483) 1.314ERCC1, ERCC5, ERCC6, ERCC2
primary metabolic process (GO:0044238) 0.694ERCC1, ERCC5, ERCC6, ERCC2
response to stimulus (GO:0050896) 1.224ERCC1, ERCC5, ERCC6, ERCC2
cellular metabolic process (GO:0044237) 0.694ERCC1, ERCC5, ERCC6, ERCC2
macromolecule metabolic process (GO:0043170) 0.834ERCC1, ERCC5, ERCC6, ERCC2
response to UV (GO:0009411) 4.884ERCC1, ERCC5, ERCC6, ERCC2
cellular response to stress (GO:0033554) 2.514ERCC1, ERCC5, ERCC6, ERCC2
DNA metabolic process (GO:0006259) 3.094ERCC1, ERCC5, ERCC6, ERCC2
positive regulation of cellular process (GO:0048522) 1.34ERCC1, ERCC5, ERCC6, ERCC2
nucleotide-excision repair, DNA incision, 3'-to lesion (GO:0006295) 6.683ERCC1, ERCC5, ERCC2
positive regulation of cellular component organization (GO:0051130) 2.683ERCC1, ERCC5, ERCC2
nucleotide-excision repair, DNA incision, 5'-to lesion (GO:0006296) 6.123ERCC1, ERCC5, ERCC2
positive regulation of metabolic process (GO:0009893) 1.743ERCC1, ERCC6, ERCC2
regulation of metabolic process (GO:0019222) 1.023ERCC1, ERCC6, ERCC2
positive regulation of cellular metabolic process (GO:0031325) 1.813ERCC1, ERCC6, ERCC2
regulation of cellular metabolic process (GO:0031323) 1.073ERCC1, ERCC6, ERCC2
regulation of cellular component organization (GO:0051128) 2.013ERCC1, ERCC5, ERCC2
nucleic acid phosphodiester bond hydrolysis (GO:0090305) 4.123ERCC1, ERCC5, ERCC2
multicellular organism growth (GO:0035264) 5.373ERCC1, ERCC6, ERCC2
UV protection (GO:0009650) 7.243ERCC1, ERCC5, ERCC2
developmental growth (GO:0048589) 4.053ERCC1, ERCC6, ERCC2
single-organism process (GO:0044699) 0.483ERCC1, ERCC6, ERCC2
regulation of primary metabolic process (GO:0080090) 1.083ERCC1, ERCC6, ERCC2
nucleotide-excision repair, preincision complex stabilization (GO:0006293) 6.683ERCC1, ERCC5, ERCC2
nucleotide-excision repair, DNA incision (GO:0033683) 6.073ERCC1, ERCC5, ERCC2
cellular component organization (GO:0016043) 1.243ERCC1, ERCC5, ERCC2
regulation of macromolecule metabolic process (GO:0060255) 1.083ERCC1, ERCC6, ERCC2
cellular component organization or biogenesis (GO:0071840) 1.223ERCC1, ERCC5, ERCC2
developmental process (GO:0032502) 1.363ERCC1, ERCC6, ERCC2
multicellular organismal process (GO:0032501) 1.453ERCC1, ERCC6, ERCC2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.353ERCC1, ERCC6, ERCC2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433ERCC1, ERCC6, ERCC2
positive regulation of protein complex assembly (GO:0031334) 4.443ERCC1, ERCC5, ERCC2
single-organism developmental process (GO:0044767) 1.493ERCC1, ERCC6, ERCC2
regulation of nitrogen compound metabolic process (GO:0051171) 1.363ERCC1, ERCC6, ERCC2
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.293ERCC1, ERCC6, ERCC2
growth (GO:0040007) 3.83ERCC1, ERCC6, ERCC2
regulation of protein complex assembly (GO:0043254) 3.833ERCC1, ERCC5, ERCC2
response to oxidative stress (GO:0006979) 3.93ERCC1, ERCC6, ERCC2
positive regulation of macromolecule metabolic process (GO:0010604) 1.813ERCC1, ERCC6, ERCC2
single-multicellular organism process (GO:0044707) 1.783ERCC1, ERCC6, ERCC2
regulation of cellular component biogenesis (GO:0044087) 3.083ERCC1, ERCC5, ERCC2
positive regulation of cellular component biogenesis (GO:0044089) 3.713ERCC1, ERCC5, ERCC2
nucleotide-excision repair, preincision complex assembly (GO:0006294) 6.362ERCC5, ERCC2
cellular component assembly (GO:0022607) 2.142ERCC5, ERCC2
pyrimidine dimer repair (GO:0006290) 7.782ERCC1, ERCC6
positive regulation of biosynthetic process (GO:0009891) 2.292ERCC6, ERCC2
macromolecular complex subunit organization (GO:0043933) 2.142ERCC5, ERCC2
regulation of cellular biosynthetic process (GO:0031326) 1.382ERCC6, ERCC2
cellular biosynthetic process (GO:0044249) 1.372ERCC6, ERCC2
positive regulation of gene expression (GO:0010628) 2.352ERCC6, ERCC2
global genome nucleotide-excision repair (GO:0070911) 6.262ERCC1, ERCC2
cellular macromolecular complex assembly (GO:0034622) 3.182ERCC5, ERCC2
organic substance biosynthetic process (GO:1901576) 1.342ERCC6, ERCC2
organic cyclic compound biosynthetic process (GO:1901362) 1.662ERCC6, ERCC2
multicellular organism development (GO:0007275) 2.542ERCC1, ERCC2
nucleic acid-templated transcription (GO:0097659) 1.912ERCC6, ERCC2
RNA biosynthetic process (GO:0032774) 1.842ERCC6, ERCC2
protein-DNA complex subunit organization (GO:0071824) 4.452ERCC5, ERCC2
DNA-templated transcription, elongation (GO:0006354) 5.152ERCC6, ERCC2
response to ionizing radiation (GO:0010212) 4.742ERCC1, ERCC6
cellular developmental process (GO:0048869) 1.822ERCC1, ERCC2
positive regulation of cellular biosynthetic process (GO:0031328) 2.32ERCC6, ERCC2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462ERCC6, ERCC2
macromolecular complex assembly (GO:0065003) 2.552ERCC5, ERCC2
transcription elongation from RNA polymerase I promoter (GO:0006362) 6.332ERCC6, ERCC2
positive regulation of molecular function (GO:0044093) 2.232ERCC6, ERCC2
transcription from RNA polymerase II promoter (GO:0006366) 3.382ERCC6, ERCC2
negative regulation of biological process (GO:0048519) 1.332ERCC1, ERCC5
regulation of molecular function (GO:0065009) 1.782ERCC6, ERCC2
regulation of gene expression (GO:0010468) 1.372ERCC6, ERCC2
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012ERCC1, ERCC2
heterocycle biosynthetic process (GO:0018130) 1.72ERCC6, ERCC2
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562ERCC6, ERCC2
response to oxygen-containing compound (GO:1901700) 2.572ERCC1, ERCC6
aging (GO:0007568) 4.162ERCC1, ERCC2
cell proliferation (GO:0008283) 3.232ERCC1, ERCC2
protein-DNA complex assembly (GO:0065004) 4.62ERCC5, ERCC2
regulation of biosynthetic process (GO:0009889) 1.372ERCC6, ERCC2
regulation of nucleic acid-templated transcription (GO:1903506) 1.552ERCC6, ERCC2
cellular macromolecule biosynthetic process (GO:0034645) 1.662ERCC6, ERCC2
biosynthetic process (GO:0009058) 1.322ERCC6, ERCC2
macromolecule biosynthetic process (GO:0009059) 1.612ERCC6, ERCC2
single-organism cellular process (GO:0044763) 0.652ERCC1, ERCC2
positive regulation of transcription, DNA-templated (GO:0045893) 2.562ERCC6, ERCC2
regulation of RNA biosynthetic process (GO:2001141) 1.552ERCC6, ERCC2
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722ERCC6, ERCC2
response to chemical (GO:0042221) 1.982ERCC1, ERCC6
response to X-ray (GO:0010165) 6.332ERCC1, ERCC6
RNA metabolic process (GO:0016070) 1.592ERCC6, ERCC2
animal organ development (GO:0048513) 2.532ERCC1, ERCC2
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592ERCC6, ERCC2
chromosome organization (GO:0051276) 3.792ERCC1, ERCC2
anatomical structure development (GO:0048856) 1.582ERCC1, ERCC2
positive regulation of RNA metabolic process (GO:0051254) 2.512ERCC6, ERCC2
positive regulation of RNA biosynthetic process (GO:1902680) 2.542ERCC6, ERCC2
regulation of transcription, DNA-templated (GO:0006355) 1.562ERCC6, ERCC2
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392ERCC6, ERCC2
regulation of macromolecule biosynthetic process (GO:0010556) 1.432ERCC6, ERCC2
transcription, DNA-templated (GO:0006351) 1.912ERCC6, ERCC2
organelle organization (GO:0006996) 2.022ERCC1, ERCC2
aromatic compound biosynthetic process (GO:0019438) 1.72ERCC6, ERCC2
regulation of RNA metabolic process (GO:0051252) 1.522ERCC6, ERCC2
negative regulation of cellular process (GO:0048523) 1.412ERCC1, ERCC5

NET-GE enrichment

Term New enriched termICP valueGenes
nucleotide-excision repair, DNA incision, 3-to lesion (GO:0006295) -6.680.0ERCC1, ERCC5
nucleotide-excision repair, DNA incision, 5-to lesion (GO:0006296) -6.120.0ERCC1, ERCC5
pyrimidine dimer repair (GO:0006290) -7.780.0ERCC1, ERCC6
response to radiation (GO:0009314) -3.690.016ERCC1, ERCC5, ERCC6, ERCC2
cellular catabolic process (GO:0044248) NEW2.620.039ERCC1, ERCC5, ERCC6, ERCC2
nucleic acid phosphodiester bond hydrolysis (GO:0090305) -4.120.004ERCC1, ERCC5, ERCC2
response to UV (GO:0009411) -4.880.0ERCC1, ERCC5, ERCC6, ERCC2
response to light stimulus (GO:0009416) -4.080.005ERCC1, ERCC5, ERCC6, ERCC2
multicellular organism growth (GO:0035264) -5.370.0ERCC1, ERCC6, ERCC2
UV protection (GO:0009650) -7.240.0ERCC1, ERCC5, ERCC2
organic cyclic compound catabolic process (GO:1901361) NEW3.730.004ERCC1, ERCC5, ERCC6, ERCC2
DNA excision (GO:0044349) NEW9.730.0ERCC1, ERCC5, ERCC2
response to X-ray (GO:0010165) -6.330.01ERCC1, ERCC6
growth (GO:0040007) -3.80.009ERCC1, ERCC6, ERCC2
nucleotide-excision repair, DNA incision (GO:0033683) -6.070.0ERCC1, ERCC5, ERCC2
DNA catabolic process (GO:0006308) NEW6.360.0ERCC1, ERCC5, ERCC2
gene expression (GO:0010467) NEW5.80.013ERCC1, ERCC5, ERCC6, ERCC2
transcription elongation from RNA polymerase I promoter (GO:0006362) -6.330.005ERCC6, ERCC2
transcription-coupled nucleotide-excision repair (GO:0006283) -5.440.0ERCC1, ERCC5, ERCC6, ERCC2
DNA repair (GO:0006281) -3.590.0ERCC1, ERCC5, ERCC6, ERCC2
nucleotide-excision repair (GO:0006289) -5.050.0ERCC1, ERCC5, ERCC6, ERCC2
cellular response to DNA damage stimulus (GO:0006974) -3.170.019ERCC1, ERCC5, ERCC6, ERCC2
aromatic compound catabolic process (GO:0019439) NEW3.790.004ERCC1, ERCC5, ERCC6, ERCC2
nucleobase-containing compound catabolic process (GO:0034655) NEW3.90.003ERCC1, ERCC5, ERCC6, ERCC2
heterocycle catabolic process (GO:0046700) NEW3.820.004ERCC1, ERCC5, ERCC6, ERCC2
response to oxidative stress (GO:0006979) -3.90.007ERCC1, ERCC6, ERCC2
response to abiotic stimulus (GO:0009628) -2.80.003ERCC1, ERCC5, ERCC6, ERCC2
nucleotide-excision repair, DNA damage removal (GO:0000718) NEW9.730.0ERCC1, ERCC5, ERCC2
cellular nitrogen compound catabolic process (GO:0044270) NEW3.80.004ERCC1, ERCC5, ERCC6, ERCC2
DNA catabolic process, endonucleolytic (GO:0000737) NEW6.780.033ERCC1, ERCC5
cellular response to stress (GO:0033554) -2.510.008ERCC1, ERCC5, ERCC6, ERCC2
DNA metabolic process (GO:0006259) -3.090.001ERCC1, ERCC5, ERCC6, ERCC2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein complex (GO:0043234) 1.514ERCC1, ERCC5, ERCC6, ERCC2
intracellular organelle part (GO:0044446) 0.814ERCC1, ERCC5, ERCC6, ERCC2
macromolecular complex (GO:0032991) 1.354ERCC1, ERCC5, ERCC6, ERCC2
intracellular membrane-bounded organelle (GO:0043231) 0.64ERCC1, ERCC5, ERCC6, ERCC2
nucleus (GO:0005634) 1.074ERCC1, ERCC5, ERCC6, ERCC2
cell part (GO:0044464) 0.114ERCC1, ERCC5, ERCC6, ERCC2
nucleoplasm (GO:0005654) 1.894ERCC1, ERCC5, ERCC6, ERCC2
intracellular organelle (GO:0043229) 0.514ERCC1, ERCC5, ERCC6, ERCC2
nucleoplasm part (GO:0044451) 3.224ERCC1, ERCC5, ERCC6, ERCC2
intracellular part (GO:0044424) 0.284ERCC1, ERCC5, ERCC6, ERCC2
nuclear part (GO:0044428) 1.554ERCC1, ERCC5, ERCC6, ERCC2
membrane-bounded organelle (GO:0043227) 0.474ERCC1, ERCC5, ERCC6, ERCC2
organelle (GO:0043226) 0.44ERCC1, ERCC5, ERCC6, ERCC2
organelle part (GO:0044422) 0.794ERCC1, ERCC5, ERCC6, ERCC2
RNA polymerase II transcription factor complex (GO:0090575) 5.183ERCC1, ERCC5, ERCC2
nuclear transcription factor complex (GO:0044798) 4.953ERCC1, ERCC5, ERCC2
transcription factor complex (GO:0005667) 4.13ERCC1, ERCC5, ERCC2
cytoplasm (GO:0005737) 1.012ERCC1, ERCC2
carboxy-terminal domain protein kinase complex (GO:0032806) 6.712ERCC5, ERCC2
catalytic complex (GO:1902494) 2.92ERCC5, ERCC2
intracellular non-membrane-bounded organelle (GO:0043232) 1.762ERCC6, ERCC2
transferase complex, transferring phosphorus-containing groups (GO:0061695) 4.612ERCC5, ERCC2
protein kinase complex (GO:1902911) 5.312ERCC5, ERCC2
serine/threonine protein kinase complex (GO:1902554) 5.452ERCC5, ERCC2
nuclear chromosome part (GO:0044454) 3.672ERCC1, ERCC5
non-membrane-bounded organelle (GO:0043228) 1.762ERCC6, ERCC2
transferase complex (GO:1990234) 3.322ERCC5, ERCC2
holo TFIIH complex (GO:0005675) 7.322ERCC5, ERCC2
chromosomal part (GO:0044427) 3.182ERCC1, ERCC5

NET-GE enrichment

Term New enriched termICP valueGenes
protein kinase complex (GO:1902911) -5.310.022ERCC1, ERCC2
RNA polymerase II transcription factor complex (GO:0090575) -5.180.004ERCC1, ERCC2
nucleoplasm (GO:0005654) -1.890.0ERCC1, ERCC5, ERCC6, ERCC2
nuclear transcription factor complex (GO:0044798) -4.950.004ERCC1, ERCC2
nuclear part (GO:0044428) -1.550.015ERCC1, ERCC5, ERCC6, ERCC2
transcription factor complex (GO:0005667) -4.10.049ERCC1, ERCC2
nucleoplasm part (GO:0044451) -3.220.006ERCC1, ERCC6, ERCC2