Disease table of HEINZ BODY ANEMIAS OMIM ID: 140700

Gene-disease associations table

GeneAssociated with HEINZ BODY ANEMIAS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
HBA1OMIMHGNC link16p13.33604131, 613978, 140700
HBA2OMIMHGNC link16p13.33604131, 613978, 140700
HBBOMIMHGNC link11p15.46140700, 141749, 603902, 603903, 611162, 613985

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Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 6812HBA1, HBA2
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
16p13.32HBA1, HBA2
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
16p132HBA1, HBA2
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
16p12HBA1, HBA2
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
16p2HBA1, HBA2
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
162HBA1, HBA2
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
ATRXNO2HBA2, HBA12HBA2, HBA1
GATA1NO52PF4, PBXIP1, CBFB, GP1BA, GP9, KLF1, FCER1A, ITGA2B, EPO, SEMG1, TBXA2R, BACE1, DACH1, PTGFR, GP6, HBA2, DPYSL2, GYPB, TAL1, CYBB, COPS5, DICER1, CDA, FURIN, GNAS, WT1, ZNF268, BDKRB1, SPI1, GP1BB, NFE2, F13A1, GFI1B, MPL, AGGF1, CCR3, GATA1, IFNG, HEMGN, HBE1, BACH1, PPOX, CEBPA, CDC6, HBB, PRG2, FLI1, EPOR, IL1RL1, SMAD1, HBG1, HBA13HBB, HBA2, HBA1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
HBA1YES2ATRX, GATA10
HBA2YES2ATRX, GATA10
HBBYES9NFYB, CEBPG, KLF1, NFYA, NFYC, CEBPB, NFE2L2, GATA1, POU2F20
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
HBA1HBA2No6FN1, UCHL5, VCAM1, OBSL1, CUL7, ITGA4
HBA1HBBYes4UCHL5, ERBB3, CEP250, PAN2
HBA2HBBNo7PGPEP1, MED4, GDPD1, UCHL5, AGA, NDUFAF5, DHRS2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
HBA1HBA2Yesbinding9HBD, HBG2, HBB, HBE1, CYB5R3, AHSP, HP, HBQ1, HBZ
HBA1HBBYesbinding10HBA2, HBZ, HBG2, HPR, HBD, HBE1, CYB5R3, AHSP, HP, HBQ1
HBA2HBBYesbinding9HBA1, HBD, HBG2, HBZ, HBE1, CYB5R3, AHSP, HP, HBQ1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
HBA1HBA2Yes6HBA2, HBB, HP, HBA1; HBA2, HBG2, HBA1
HBA1HBBYes5HBB, HBA1; HBA2, HP, HBA2, HBA1
HBA2HBBYes5HBB, HBA1; HBA2, HP, HBA2, HBA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
HBA1HBA2yes, complexThey form a tetramer. [Uniprot]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
African trypanosomiasishsa051437.683HBB, HBA2, HBA1
Malariahsa051447.153HBB, HBA2, HBA1

NET-GE enrichment

Term New enriched termICP valueGenes
African trypanosomiasis (hsa05143) -7.680.001HBB, HBA1
Infectious diseases: ParasiticNEW4.460.01HBB, HBA1
Malaria (hsa05144) -7.150.0HBB, HBA1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Scavenging of heme from plasmaR-HSA-21688805.613HBB, HBA2, HBA1
O2/CO2 exchange in erythrocytesR-HSA-14809269.983HBB, HBA2, HBA1
Erythrocytes take up oxygen and release carbon dioxideR-HSA-12476739.983HBB, HBA2, HBA1
MetabolismR-HSA-14307282.343HBB, HBA2, HBA1
Binding and Uptake of Ligands by Scavenger ReceptorsR-HSA-21737825.383HBB, HBA2, HBA1
Erythrocytes take up carbon dioxide and release oxygenR-HSA-12370449.983HBB, HBA2, HBA1
Vesicle-mediated transportR-HSA-56536564.333HBB, HBA2, HBA1

NET-GE enrichment

Term New enriched termICP valueGenes
Scavenging of heme from plasma (R-HSA-2168880) -5.610.006HBB, HBA1
O2/CO2 exchange in erythrocytes (R-HSA-1480926) -9.980.0HBB, HBA1
Erythrocytes take up oxygen and release carbon dioxide (R-HSA-1247673) -9.980.0HBB, HBA1
Factors involved in megakaryocyte development and platelet production (R-HSA-983231) NEW5.880.02HBB, HBA1
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782) -5.380.012HBB, HBA1
Erythrocytes take up carbon dioxide and release oxygen (R-HSA-1237044) -9.980.0HBB, HBA1
Vesicle-mediated transport (R-HSA-5653656) -4.330.025HBB, HBA1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cation binding (GO:0043169) 1.43HBB, HBA2, HBA1
oxygen transporter activity (GO:0005344) 7.173HBB, HBA2, HBA1
substrate-specific transporter activity (GO:0022892) 2.723HBB, HBA2, HBA1
heme binding (GO:0020037) 4.863HBB, HBA2, HBA1
transition metal ion binding (GO:0046914) 2.483HBB, HBA2, HBA1
tetrapyrrole binding (GO:0046906) 4.83HBB, HBA2, HBA1
transporter activity (GO:0005215) 2.573HBB, HBA2, HBA1
ion binding (GO:0043167) 1.363HBB, HBA2, HBA1
oxygen binding (GO:0019825) 5.893HBB, HBA2, HBA1
binding (GO:0005488) 0.183HBB, HBA2, HBA1
organic cyclic compound binding (GO:0097159) 1.053HBB, HBA2, HBA1
iron ion binding (GO:0005506) 4.653HBB, HBA2, HBA1
metal ion binding (GO:0046872) 1.413HBB, HBA2, HBA1
heterocyclic compound binding (GO:1901363) 1.063HBB, HBA2, HBA1
antioxidant activity (GO:0016209) 5.492HBB, HBA1
haptoglobin binding (GO:0031720) 9.052HBB, HBA1
catalytic activity (GO:0003824) 1.052HBB, HBA1
protein binding (GO:0005515) 0.462HBB, HBA1
oxidoreductase activity, acting on peroxide as acceptor (GO:0016684) 6.02HBB, HBA1
peroxidase activity (GO:0004601) 6.052HBB, HBA1
oxidoreductase activity (GO:0016491) 3.122HBB, HBA1

NET-GE enrichment

Term New enriched termICP valueGenes
oxygen transporter activity (GO:0005344) -7.170.0HBB, HBA1
oxygen binding (GO:0019825) -5.890.002HBB, HBA1
heme binding (GO:0020037) -4.860.001HBB, HBA1
tetrapyrrole binding (GO:0046906) -4.80.001HBB, HBA1
hemoglobin binding (GO:0030492) NEW8.130.011HBB, HBA1
iron ion binding (GO:0005506) -4.650.002HBB, HBA1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
transport (GO:0006810) 1.513HBB, HBA2, HBA1
gas transport (GO:0015669) 6.783HBB, HBA2, HBA1
single-organism transport (GO:0044765) 2.183HBB, HBA2, HBA1
single-organism process (GO:0044699) 0.483HBB, HBA2, HBA1
single-organism localization (GO:1902578) 2.093HBB, HBA2, HBA1
establishment of localization (GO:0051234) 1.483HBB, HBA2, HBA1
localization (GO:0051179) 1.43HBB, HBA2, HBA1
oxygen transport (GO:0015671) 7.093HBB, HBA2, HBA1
bicarbonate transport (GO:0015701) 5.972HBB, HBA1
cellular component assembly (GO:0022607) 2.142HBB, HBA1
macromolecular complex subunit organization (GO:0043933) 2.142HBB, HBA1
response to reactive oxygen species (GO:0000302) 4.52HBB, HBA1
cellular catabolic process (GO:0044248) 2.622HBB, HBA1
anion transport (GO:0006820) 3.712HBB, HBA1
hydrogen peroxide catabolic process (GO:0042744) 6.782HBB, HBA1
hydrogen peroxide metabolic process (GO:0042743) 6.332HBB, HBA1
detoxification (GO:0098754) 5.372HBB, HBA1
positive regulation of cell death (GO:0010942) 3.322HBB, HBA1
regulation of cell death (GO:0010941) 2.432HBB, HBA1
regulation of biological process (GO:0050789) 0.452HBB, HBA1
cellular component organization or biogenesis (GO:0071840) 1.222HBB, HBA1
cellular oxidant detoxification (GO:0098869) 5.452HBB, HBA1
protein complex subunit organization (GO:0071822) 2.62HBB, HBA1
cellular component organization (GO:0016043) 1.242HBB, HBA1
macromolecular complex assembly (GO:0065003) 2.552HBB, HBA1
biological regulation (GO:0065007) 0.392HBB, HBA1
organic substance transport (GO:0071702) 2.152HBB, HBA1
positive regulation of biological process (GO:0048518) 1.22HBB, HBA1
response to oxygen-containing compound (GO:1901700) 2.572HBB, HBA1
protein complex assembly (GO:0006461) 2.782HBB, HBA1
ion transport (GO:0006811) 2.662HBB, HBA1
cellular process (GO:0009987) 0.262HBB, HBA1
protein heterooligomerization (GO:0051291) 5.222HBB, HBA1
organic anion transport (GO:0015711) 4.072HBB, HBA1
reactive oxygen species metabolic process (GO:0072593) 5.142HBB, HBA1
regulation of cellular process (GO:0050794) 0.52HBB, HBA1
cellular detoxification (GO:1990748) 5.412HBB, HBA1
metabolic process (GO:0008152) 0.582HBB, HBA1
response to chemical (GO:0042221) 1.982HBB, HBA1
response to inorganic substance (GO:0010035) 3.562HBB, HBA1
catabolic process (GO:0009056) 2.382HBB, HBA1
response to oxidative stress (GO:0006979) 3.92HBB, HBA1
protein oligomerization (GO:0051259) 3.712HBB, HBA1
endocytosis (GO:0006897) 3.692HBB, HBA1
vesicle-mediated transport (GO:0016192) 2.722HBB, HBA1
response to hydrogen peroxide (GO:0042542) 5.022HBB, HBA1
response to stimulus (GO:0050896) 1.222HBB, HBA1
receptor-mediated endocytosis (GO:0006898) 4.312HBB, HBA1
response to stress (GO:0006950) 1.82HBB, HBA1
cellular metabolic process (GO:0044237) 0.692HBB, HBA1
positive regulation of cellular process (GO:0048522) 1.32HBB, HBA1

NET-GE enrichment

Term New enriched termICP valueGenes
bicarbonate transport (GO:0015701) -5.970.0HBB, HBA1
positive regulation of vasoconstriction (GO:0045907) NEW6.120.003HBB, HBA1
regulation of vasoconstriction (GO:0019229) NEW5.510.012HBB, HBA1
response to reactive oxygen species (GO:0000302) -4.50.006HBB, HBA1
protein stabilization (GO:0050821) NEW4.860.033HBB, HBA1
vascular process in circulatory system (GO:0003018) NEW4.650.033HBB, HBA1
positive regulation of nitric oxide biosynthetic process (GO:0045429) NEW5.990.003HBB, HBA1
hydrogen peroxide catabolic process (GO:0042744) -6.780.0HBB, HBA1
hydrogen peroxide metabolic process (GO:0042743) -6.330.003HBB, HBA1
positive regulation of cell death (GO:0010942) -3.320.049HBB, HBA1
regulation of blood vessel size (GO:0050880) NEW4.80.018HBB, HBA1
oxygen transport (GO:0015671) -7.090.0HBB, HBA1
regulation of tube size (GO:0035150) NEW4.790.02HBB, HBA1
cellular response to reactive oxygen species (GO:0034614) NEW5.220.039HBB, HBA1
cellular response to hydrogen peroxide (GO:0070301) NEW5.650.017HBB, HBA1
protein heterooligomerization (GO:0051291) -5.220.002HBB, HBA1
organic anion transport (GO:0015711) -4.070.03HBB, HBA1
reactive oxygen species metabolic process (GO:0072593) -5.140.002HBB, HBA1
cellular response to oxidative stress (GO:0034599) NEW4.70.006HBB, HBA1
response to inorganic substance (GO:0010035) -3.560.037HBB, HBA1
response to oxidative stress (GO:0006979) -3.90.024HBB, HBA1
protein oligomerization (GO:0051259) -3.710.038HBB, HBA1
response to hydrogen peroxide (GO:0042542) -5.020.002HBB, HBA1
gas transport (GO:0015669) -6.780.001HBB, HBA1
regulation of nitric oxide biosynthetic process (GO:0045428) NEW5.760.008HBB, HBA1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein complex (GO:0043234) 1.513HBB, HBA2, HBA1
macromolecular complex (GO:0032991) 1.353HBB, HBA2, HBA1
cell part (GO:0044464) 0.113HBB, HBA2, HBA1
hemoglobin complex (GO:0005833) 7.43HBB, HBA2, HBA1
cytoplasmic part (GO:0044444) 0.823HBB, HBA2, HBA1
cytosolic part (GO:0044445) 4.343HBB, HBA2, HBA1
intracellular part (GO:0044424) 0.283HBB, HBA2, HBA1
membrane-enclosed lumen (GO:0031974) 3.052HBB, HBA1
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) 5.192HBB, HBA1
membrane-bounded organelle (GO:0043227) 0.472HBB, HBA1
organelle (GO:0043226) 0.42HBB, HBA1
vesicle lumen (GO:0031983) 5.172HBB, HBA1
extracellular exosome (GO:0070062) 1.892HBB, HBA1
endocytic vesicle lumen (GO:0071682) 7.032HBB, HBA1
membrane (GO:0016020) 0.682HBB, HBA1
blood microparticle (GO:0072562) 4.882HBB, HBA1
membrane-bounded vesicle (GO:0031988) 1.712HBB, HBA1
cytoplasmic vesicle part (GO:0044433) 3.412HBB, HBA1
extracellular vesicle (GO:1903561) 1.892HBB, HBA1
vesicle (GO:0031982) 1.642HBB, HBA1
extracellular organelle (GO:0043230) 1.892HBB, HBA1
organelle lumen (GO:0043233) 3.052HBB, HBA1
cytosol (GO:0005829) 1.682HBB, HBA1
intracellular organelle part (GO:0044446) 0.812HBB, HBA1
intracellular organelle lumen (GO:0070013) 3.052HBB, HBA1
extracellular region (GO:0005576) 2.182HBB, HBA1
haptoglobin-hemoglobin complex (GO:0031838) 8.72HBB, HBA1
extracellular region part (GO:0044421) 1.572HBB, HBA1
organelle part (GO:0044422) 0.792HBB, HBA1

NET-GE enrichment

Term New enriched termICP valueGenes
vesicle lumen (GO:0031983) -5.170.001HBB, HBA1
endocytic vesicle lumen (GO:0071682) -7.030.0HBB, HBA1
organelle lumen (GO:0043233) -3.050.037HBB, HBA1
haptoglobin-hemoglobin complex (GO:0031838) -8.70.0HBB, HBA1
blood microparticle (GO:0072562) -4.880.022HBB, HBA1
hemoglobin complex (GO:0005833) -7.40.0HBB, HBA1
cytoplasmic vesicle part (GO:0044433) -3.410.03HBB, HBA1
cytosolic part (GO:0044445) -4.340.014HBB, HBA1
membrane-enclosed lumen (GO:0031974) -3.050.044HBB, HBA1
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) -5.190.001HBB, HBA1
ribosomal subunit (GO:0044391) NEW4.670.004HBB, HBA1