Disease table of LEUKEMIA, ACUTE MYELOID OMIM ID: 601626

Gene-disease associations table

GeneAssociated with LEUKEMIA, ACUTE MYELOID inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TGM6ClinVarHGNC link20p132601626, PS164400
SETBP1HUMSAVARHGNC link18q12.36601626, 614286, 608232, 269150, PS156200, 607785
SH3GL1OMIMHGNC link19p13.31601626
FLT3ClinVar, OMIMHGNC link13q12.22601626, 613065
CHIC2OMIMHGNC link4q121601626
CEBPAClinVar, OMIM, HUMSAVARHGNC link19q13.111601626
NPM1ClinVar, OMIMHGNC link5q35.11601626
WHSC1L1OMIMHGNC link8p11.231601626
CBFBOMIMHGNC link16q22.11601626
JAK2ClinVar, OMIM, HUMSAVARHGNC link9p24.15263300, 601626, 254450, PS133100, PS187950
NUP214OMIMHGNC link9q34.132601626, 613065
TERTClinVar, OMIMHGNC link5p15.335PS127550, 601626, 178500, PS155600, PS614742
MLF1OMIMHGNC link3q25.321601626
MLLT10OMIMHGNC link10p12.311601626
LPPOMIMHGNC link3q27.31601626
GATA2OMIMHGNC link3q21.34601626, 614286, 614038, 614172
KRASClinVar, OMIMHGNC link12p12.114601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350
ETV6ClinVar, OMIMHGNC link12p13.22601626, 616216
DDX41ClinVarHGNC link5q35.32601626, 616871
KITClinVar, OMIMHGNC link4q125601626, 172800, 273300, 606764, 154800
RUNX1OMIMHGNC link21q22.122601626, 601399
NSD1OMIMHGNC link5q35.33601626, 130650, PS117550
PICALMOMIMHGNC link11q14.21601626

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
4q122CHIC2, KIT
5q35.32DDX41, NSD1
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
4q122CHIC2, KIT
5q353NPM1, DDX41, NSD1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
12p12KRAS, ETV6
3q23MLF1, GATA2, LPP
4q12CHIC2, KIT
5q33NPM1, DDX41, NSD1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
5q3NPM1, DDX41, NSD1
3q3MLF1, GATA2, LPP
4q2CHIC2, KIT
12p2KRAS, ETV6
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
122KRAS, ETV6
192CEBPA, SH3GL1
33MLF1, GATA2, LPP
54NPM1, TERT, NSD1, DDX41
42CHIC2, KIT
92JAK2, NUP214
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SETBP1YES3PTGS2, PTGER2, PPP2R40
CEBPAYES50FN1, PRL, CXCR2, VLDLR, SLC2A4, TLR9, S100A9, CSF3R, MSR1, CSF1, AFP, ICAM1, SFTPD, ITGAX, INSR, HAMP, ELANE, STAR, SOCS3, DEFA1, CSF2RA, ID1, CYP3A4, SAA1, HOMER3, IGF1, GAPDH, PCK1, SLC10A1, CD163, SPP1, IL10, DEFA3, PCK2, F9, MAD1L1, SERPINC1, CDK2, BCL2, IL3, HSPA4, ALB, IGF2, IL5, IL6, HSD17B11, CRMP1, MYC, LEP, PRTN30
NPM1YES6CDKN1A, PTPN6, TAF1A, ATF5, DNMT1, RPL30
CBFBYES1GATA10
MLLT10YES3CDKN1A, BAX, MDM20
GATA2YES16WT1, PECAM1, CEBPA, DPYSL2, SPI1, PRG2, NOS3, CYBB, EPO, TSHB, GATA1, IL1RL1, ANGPT2, ERVW-1, PPARG, ADH1A1CEBPA
ETV6YES5CDKN1A, BBC3, GAS2, MAD2L1, IGFBP50
RUNX1YES36PF4, GP1BA, ITGA2B, MAD2L1, LGALS3, NCAM1, CCND2, BPI, SLC22A4, CSF1, MECOM, CCL3, BAALC, CSF2, SPI1, IL2, CD34, MYL9, ITGB2, CSF1R, TIMP1, VEGFA, MYH10, FHL2, MPO, KLK3, NF1, IL3, SYMPK, JUN, ELANE, PRKCQ, MPL, PIK3CD, KLF4, CD60
NSD1YES1AR0
PITX1NO13IRF2, TERT, RUNX2, PRL, IFNA1, HES1, NKX3-1, IRF7, JUN, TBX4, TRIB2, LHB, RUNX12RUNX1, TERT
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP124ETV6, FLT3, JAK2, TERT
MYCNO102CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC14CBFB, KRAS, TERT, CEBPA
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC13CBFB, KIT, TERT
GATA1NO52PF4, PBXIP1, CBFB, GP1BA, GP9, KLF1, FCER1A, ITGA2B, EPO, SEMG1, TBXA2R, BACE1, DACH1, PTGFR, GP6, HBA2, DPYSL2, GYPB, TAL1, CYBB, COPS5, DICER1, CDA, FURIN, GNAS, WT1, ZNF268, BDKRB1, SPI1, GP1BB, NFE2, F13A1, GFI1B, MPL, AGGF1, CCR3, GATA1, IFNG, HEMGN, HBE1, BACH1, PPOX, CEBPA, CDC6, HBB, PRG2, FLI1, EPOR, IL1RL1, SMAD1, HBG1, HBA12CBFB, CEBPA
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
FLT3YES2PML, STAT30
CEBPAYES8LEF1, PPARA, GATA2, DDIT3, MYB, GATA1, MYC, PPARG1GATA2
CBFBYES3SP1, MYC, GATA10
JAK2YES3BRCA1, STAT3, STAT10
TERTYES30CTCF, MZF1, ETS2, MXD1, USF2, SP1, ID2, TAL1, SMAD3, DNMT1, E2F1, WT1, ESR2, HDAC1, JUN, TP53, RELA, NFKB1, TP73, ETS1, HIF1A, STAT3, MEN1, NFATC2, FLI1, USF1, ESR1, MYC, PITX1, MYCN0
GATA2YES1NANOG0
KRASYES1MYC0
ETV6YES1STAT30
KITYES4SP1, TFAP2A, MITF, RBMX0
RUNX1YES4HLF, RUNX3, L3MBTL1, PITX10
ELANENO7RUNX2, LEF1, SPI1, GFI1, MYB, CEBPA, RUNX12RUNX1, CEBPA
GATA1NO10CBFB, CEBPE, POU2F1, SPI1, GATA2, FLI1, MYB, BCL11A, GATA1, MYC2CBFB, GATA2
CSF1NO8CEBPA, SPI1, PPARG, NFKB1, JUN, ABL1, RELA, RUNX12RUNX1, CEBPA
CDKN1ANO118ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING13MLLT10, ETV6, NPM1
SPI1NO9CEBPE, FOS, HOXC13, SATB1, JUN, GATA1, RUNX1, GATA2, POU2F22GATA2, RUNX1
IL3NO12SP1, VEZF1, CEBPA, EGR1, RUNX1T1, CEBPB, JUN, DNMT1, JUND, RUNX1, JUNB, ETS12RUNX1, CEBPA
MAD2L1NO4BRCA1, RUNX1, ETV6, POU2F12RUNX1, ETV6
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SETBP1CHIC2No1PLEKHF2
SETBP1NPM1No2APP, PPP2CA
SETBP1WHSC1L1No1UBE2I
SETBP1NUP214No1UBE2I
SETBP1KRASNo1APP
SETBP1ETV6No1UBE2I
SH3GL1CHIC2No1ITSN2
SH3GL1CEBPANo1EWSR1
SH3GL1NPM1No7CALU, AURKA, RPA1, EWSR1, NSUN2, PML, YWHAZ
SH3GL1TERTNo3PML, PFDN1, YWHAZ
SH3GL1LPPNo5SH3GLB1, CALR, ARPC4, TPRKB, NIF3L1
SH3GL1GATA2No1PML
SH3GL1KRASNo1PML
SH3GL1KITNo1PTPRO
SH3GL1RUNX1No3PML, PRMT1, CREBBP
SH3GL1PICALMNo2EWSR1, SH3GLB2
FLT3NPM1No4SIAH1, GRB2, PIK3R1, HSP90AA1
FLT3JAK2No5PIK3R1, GRB2, IKBKG, SOCS1, HSP90AA1
FLT3TERTNo1HSP90AA1
FLT3ETV6No2GRB2, SOCS1
FLT3DDX41No1SIAH1
FLT3KITNo4GRB2, SOCS1, PIK3R1, CBL
FLT3RUNX1No2SIAH1, UBE2L6
CHIC2CEBPANo1ELAVL1
CHIC2CBFBNo1ELAVL1
CHIC2MLLT10No1ELAVL1
CHIC2LPPNo1ELAVL1
CHIC2GATA2No6KRTAP10-9, ELAVL1, KRTAP10-3, MDFI, KRT40, NOTCH2NL
CHIC2KRASNo2ELAVL1, MDFI
CHIC2ETV6No1ELAVL1
CHIC2RUNX1No1ELAVL1
CEBPANPM1No12CDKN1A, SMARCA4, CDK2, HDAC1, HDAC2, RARA, EWSR1, RB1, ESR1, PARP1, C1QBP, CHD1
CEBPAWHSC1L1No3SMARCA2, ESR1, SMARCA4
CEBPACBFBNo2MYC, ELAVL1
CEBPAJAK2No1SKP2
CEBPANUP214No3SMAD3, RANBP2, SMAD4
CEBPATERTNo2XRCC6, XRCC5
CEBPAMLLT10No1ELAVL1
CEBPALPPNo2UBE3A, ELAVL1
CEBPAGATA2No5JUN, ZBTB16, ELAVL1, SPI1, SMAD4
CEBPAKRASNo2HNRNPC, ELAVL1
CEBPAETV6No2KAT5, ELAVL1
CEBPARUNX1No12SPI1, VDR, HDAC1, HDAC2, ELAVL1, CEBPB, JUN, SMAD3, RARA, SMARCA4, MYC, FOS
CEBPANSD1No4VDR, AR, ESR1, RARA
CEBPAPICALMNo1EWSR1
NPM1WHSC1L1No9HIST3H3, ESR1, HIST1H1A, HIST1H4A, AKT1, SMARCA4, CDKN2A, HIST1H3A, GLYR1
NPM1CBFBNo1CUL5
NPM1JAK2No9PLCG1, PPP1CC, HIST3H3, PIK3R1, HSP90AA1, NAP1L1, HSP90AB1, BRCA1, GRB2
NPM1NUP214No19CUL2, OBSL1, CUL7, IPO5, HDAC5, NUP62, SIRT7, CFL1, XPO1, NXF1, RPL19, REV, TRIM28, FBXO6, NTRK1, EEF1A1, CUL3, G3BP1, ITGA4
NPM1TERTNo15EIF2S1, NAT10, RELA, MDM2, ANXA2, SERBP1, HSPA4, HSP90AA1, DYRK2, YWHAZ, AKT1, NCL, YWHAQ, PML, ENO1
NPM1MLF1No3AKAP11, KIF11, MAP1B
NPM1MLLT10No2AFF1, DOT1L
NPM1LPPNo4PPP2R1A, HSPA5, COPS5, XPO1
NPM1GATA2No6GOLGA2, CUL1, AKT1, HDAC5, EP300, PML
NPM1KRASNo7PHB, DDX50, PML, RPS29, DDX47, EEF1A1, APP
NPM1ETV6No1GRB2
NPM1DDX41No7OBSL1, SIAH1, MOV10, USP36, NTRK1, NXF1, CUL3
NPM1KITNo6PLCG1, GRB7, CLTC, CD81, PIK3R1, GRB2
NPM1RUNX1No9ELF4, HDAC1, HDAC2, RARA, SIAH1, SMARCA4, TAT, EP300, PML
NPM1NSD1No11AFF1, HIST3H3, RELA, HIST1H1D, HIST1H1C, SIRT7, HIST1H1B, RARA, ESR1, HIST1H3A, HIST1H4A
NPM1PICALMNo13FN1, FUS, MCM2, VCAM1, PLCG1, XPO1, EWSR1, ITGA4, CLTC, NTRK1, EEF1A1, DDX1, SIRT1
WHSC1L1JAK2No1HIST3H3
WHSC1L1NUP214No1UBE2I
WHSC1L1TERTNo1AKT1
WHSC1L1MLLT10No1YEATS4
WHSC1L1GATA2No1AKT1
WHSC1L1ETV6No1UBE2I
WHSC1L1RUNX1No2SMARCC1, SMARCA4
WHSC1L1NSD1No4HIST1H3A, HIST3H3, ESR1, HIST1H4A
CBFBJAK2No1PPIA
CBFBTERTNo1PPIA
CBFBMLLT10No1ELAVL1
CBFBLPPNo1ELAVL1
CBFBGATA2No1ELAVL1
CBFBKRASNo2ELAVL1, SERPINB5
CBFBETV6No1ELAVL1
CBFBRUNX1Yes7KMT2A, ELAVL1, COPRS, MYOD1, MYC, RUNX1, VIF
CBFBPICALMNo1SLC25A32
JAK2NUP214No1KPNB1
JAK2TERTNo2PPIA, HSP90AA1
JAK2LPPNo1VHL
JAK2KRASNo4TRAF6, CALM1, RAF1, DNAJA3
JAK2ETV6No3GRB2, SOCS1, SOCS3
JAK2KITYes14PTPN11, PTPN6, PIK3R1, PLCG1, TEC, STAT5B, JAK2, GRB10, SOCS1, LYN, JAK3, SRC, GRB2, STAT1
JAK2RUNX1No1TRAF6
JAK2NSD1No1HIST3H3
JAK2PICALMNo2PLCG1, EGFR
NUP214MLLT10No1UBE2I
NUP214LPPNo1XPO1
NUP214GATA2No2HDAC5, SMAD4
NUP214KRASNo2EEF1A1, NUP107
NUP214ETV6No3HDAC9, UBE2I, SOX2
NUP214DDX41No4NTRK1, NXF1, OBSL1, CUL3
NUP214RUNX1No4SMAD1, SMAD3, SMAD2, SOX2
NUP214NSD1No1SIRT7
NUP214PICALMNo5NTRK1, EEF1A1, ITGA4, XPO1, SOX2
TERTGATA2No2PML, AKT1
TERTKRASNo1PML
TERTRUNX1No2PML, STUB1
TERTNSD1No1RELA
MLF1KRASNo1PDE4DIP
MLLT10LPPNo1ELAVL1
MLLT10GATA2No1ELAVL1
MLLT10KRASNo1ELAVL1
MLLT10ETV6No1ELAVL1
MLLT10RUNX1No2SMARCB1, ELAVL1
MLLT10NSD1No1AFF1
LPPGATA2No1ELAVL1
LPPKRASNo1ELAVL1
LPPETV6No1ELAVL1
LPPRUNX1No1ELAVL1
LPPPICALMYes2NPLOC4, XPO1
GATA2KRASNo4PML, PSMA3, ELAVL1, MDFI
GATA2ETV6No3HDAC3, SKP1, ELAVL1
GATA2RUNX1No8CDK1, SPI1, PML, HDAC3, ELAVL1, JUN, TAL1, EP300
KRASETV6No1ELAVL1
KRASKITNo2PIK3CG, PIK3R2
KRASRUNX1No3PML, TRAF6, ELAVL1
KRASPICALMNo3UNK, EEF1A1, LIMA1
ETV6DDX41No1HDAC6
ETV6KITNo3GRB2, SOCS1, CRKL
ETV6RUNX1No5SIN3A, HDAC3, NCOR1, ELAVL1, SOX2
ETV6PICALMNo1SOX2
DDX41RUNX1No1SIAH1
DDX41PICALMNo3NTRK1, SNW1, CDC5L
KITPICALMNo2PLCG1, CLTC
RUNX1NSD1No2VDR, RARA
RUNX1PICALMNo1SOX2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SETBP1NUP214No-1SET
SH3GL1FLT3No-2UBC, CBL
SH3GL1CHIC2No-1UBC
SH3GL1CEBPANo-2UBC, CREBBP
SH3GL1NPM1No-1UBC
SH3GL1CBFBNo-1UBC
SH3GL1JAK2No-9KIT, CBL, CBLC, UBC, EGFR, SRC, CBLB, FYN, YES1
SH3GL1TERTNo-4SRC, UBC, CREBBP, EGFR
SH3GL1KRASNo-8KIT, RET, UBC, YES1, EGFR, SRC, FYN, ERBB4
SH3GL1ETV6No-1UBC
SH3GL1DDX41No-1UBC
SH3GL1KITYesactivation, binding10CREBBP, CBLC, SH3KBP1, UBC, CBL, SH3GL2, SRC, CBLB, FYN, YES1
SH3GL1RUNX1No-3UBC, CREBBP, CSF1R
SH3GL1PICALMNo-4UBC, SYNJ1, BIN2, DNM1
FLT3CHIC2No-1UBC
FLT3CEBPAYesinhibition, binding5SPI1, UBC, PTPN11, SIRT1, CTNNB1
FLT3NPM1No-4UBC, GRB2, SIRT1, AKT1
FLT3CBFBNo-1UBC
FLT3JAK2No-21STAT5B, STAT3, STAT5A, PIK3R3, SPI1, PTPN12, PIK3R5, SOCS6, PHLPP2, PIK3CA, PHLPP1, PIK3CB, GRB2, PIK3CG, UBC, HSP90AA1, PIK3CD, SOCS1, SOCS2, CBL, PTPN11
FLT3TERTNo-7STAT3, AKT1, PTPN11, HSP90AA1, CTNNB1, UBC, SIRT1
FLT3MLLT10No-1CTNNB1
FLT3KRASNo-9PTPN11, PIK3CG, PIK3CA, PIK3CB, HSP90AA1, AKT1, UBC, GRB2, PIK3CD
FLT3ETV6No-2UBC, NCOR1
FLT3DDX41No-2UBC, PTPN11
FLT3KITNo-20STAT5B, STAT3, PHLPP2, PHLPP1, SPI1, PTPN11, CBL, SOCS6, PIK3CB, HSP90AA1, PIK3R3, STAT5A, MYB, PIK3CA, PIK3CG, UBC, PIK3CD, SOCS1, PIK3R5, GRB2
FLT3RUNX1No-8PTPN11, CEBPA, SPI1, STAT5B, STAT5A, UBC, PIM1, NCOR1
FLT3NSD1No-1MEIS1
FLT3PICALMNo-1UBC
CHIC2CEBPANo-1UBC
CHIC2NPM1No-1UBC
CHIC2CBFBNo-1UBC
CHIC2JAK2No-1UBC
CHIC2TERTNo-1UBC
CHIC2KRASNo-1UBC
CHIC2ETV6No-1UBC
CHIC2DDX41No-1UBC
CHIC2KITNo-1UBC
CHIC2RUNX1No-1UBC
CHIC2PICALMNo-1UBC
CEBPANPM1No-11CDKN1A, BCL2, CDK2, ATF5, RARA, UBC, RB1, CDK4, MAX, MYC, SIRT1
CEBPACBFBNo-4UBC, FOS, RUNX1, ATF2
CEBPAJAK2No-9PTPN11, BCL2, SPI1, PRL, KLK3, UBC, LEP, FOS, MYC
CEBPANUP214No-1HDAC1
CEBPATERTNo-14SP1, PTPN11, CTNNB1, EP300, HDAC1, RB1, MAX, JUN, ESR1, UBC, MYC, FOS, CREBBP, SIRT1
CEBPAMLLT10No-1CTNNB1
CEBPAKRASNo-11PTPN11, BCL2, MAPK11, ETS2, JUN, CEBPD, MAPK13, UBC, MAPK14, MAPK12, ETS1
CEBPAETV6No-1UBC
CEBPADDX41No-5UBC, PTPN11, FOS, CDK2, BCL2
CEBPAKITNo-6PTPN11, SPI1, CREBBP, ETS2, UBC, MYC
CEBPARUNX1Yesactivation, binding14SP1, CREBBP, PTPN11, SPI1, EP300, HDAC1, CDKN1A, RARA, CEBPB, JUN, UBC, FOS, RUNX1T1, ETS1
CEBPANSD1No-1ESR1
CEBPAPICALMNo-1UBC
NPM1CBFBNo-1UBC
NPM1JAK2No-6BCL2, HRAS, INS, UBC, GRB2, MYC
NPM1NUP214Yesbinding26MDM2, NUP37, RAN, NUP35, NUP160, NUP88, NUP85, NUP93, SUMO1, AAAS, RAE1, NUP153, TPR, KPNB1, NUP133, NUP107, NUP205, NUP210, NUP155, NUP188, NUP43, NUP62, NUP50, NUP54, RANBP2, NUPL2
NPM1TERTNo-17HIF1A, RUVBL1, ABL1, ARNT, IRF1, TP53, UBC, RB1, MDM2, RBBP7, AKT1, NCL, MAX, MYC, RBBP4, MTOR, SIRT1
NPM1MLF1No-2MLF1IP, PLK1
NPM1KRASYesbinding10AKT1, BCL2, HRAS, ABL1, MTOR, TP53, CTGF, UBC, GRB2, NCL
NPM1ETV6No-3UBC, SUMO2, SUMO1
NPM1DDX41No-4UBC, INS, CDK2, BCL2
NPM1KITNo-7MDM2, HRAS, KRAS, INS, UBC, GRB2, MYC
NPM1RUNX1No-6CDKN1A, CDK6, PML, TP53, RARA, UBC
NPM1PICALMNo-1UBC
CBFBJAK2No-2UBC, FOS
CBFBNUP214No-2SMAD3, SMAD4
CBFBTERTNo-3UBC, FOS, SMAD3
CBFBKRASNo-1UBC
CBFBETV6No-1UBC
CBFBDDX41No-2UBC, FOS
CBFBKITNo-1UBC
CBFBRUNX1Yesbinding5RUNX3, UBC, SMAD3, FOS, SMAD4
CBFBPICALMNo-1UBC
JAK2TERTNo-16WT1, STAT3, IFNAR2, IL2, KITLG, NFKB1, MAPK1, PTPN11, IFNG, UBC, HSP90AA1, EGFR, SRC, MYC, FOS, CDKN1B
JAK2KRASNo-34BCL2L1, EGFR, MAPK3, PTPN11, IL8, BTRC, SHC2, PIK3CG, HBEGF, LGALS3, BCL2, PTK2, ERBB2, ERBB3, CCR5, RAF1, SOS1, SHC1, KIT, HRAS, PRMT5, HSP90AA1, SHC3, SRC, FYN, GRB2, YES1, MAPK1, PIK3CB, IRS1, IRS2, PIK3CA, UBC, PIK3CD
JAK2ETV6No-4UBC, MAPK3, MAPK1, PDGFRB
JAK2DDX41No-11PTPN11, STAT2, BCL2, VAV1, INS, ERBB2, PTK2, UBC, CCR7, FOS, BCAR1
JAK2KITYesactivation, binding55MYC, BCL2L1, KITLG, PLCG1, EPO, LYN, SHC2, PIK3CG, PDGFB, CBLB, BCR, STAT5B, GRB2, PHLPP2, SPI1, IL4, PIK3R5, SOCS6, STAT5A, PIK3CA, SOCS1, SHC4, SOS1, SHC1, SH2B3, CSF2, PHLPP1, LCK, HRAS, IL2, GAB2, HSP90AA1, PIK3CB, VAV1, PIK3R3, SRC, FYN, GAB1, YES1, STAT3, SOCS7, PTPN11, CBL, TEC, SHC3, CBLC, INS, IL3, PIK3R1, CRKL, UBC, IRS1, PIK3CD, CXCL12, EPOR
JAK2RUNX1No-10PTPN11, STAT5A, PDGFRB, SPI1, CSF2, MPL, STAT5B, UBC, CCL3, FOS
JAK2PICALMNo-1UBC
NUP214TERTNo-3HDAC1, SMAD3, MDM2
NUP214MLF1No-1XPO1
NUP214KRASNo-1NPM1
NUP214ETV6No-1SUMO1
NUP214KITNo-2MAPK8, MDM2
NUP214RUNX1No-5SMAD1, HDAC1, SMAD3, SMAD2, SMAD4
TERTMLLT10No-1CTNNB1
TERTKRASNo-15HSP90AA1, PTPN11, AKT1, CCND1, ABL1, MAPK1, JUN, TP53, UBC, RPS6KB1, MTOR, EGFR, SRC, EGF, NCL
TERTETV6No-3UBC, SIN3A, MAPK1
TERTDDX41No-3UBC, PTPN11, FOS
TERTKITNo-14MYC, PTPN11, IL2, KITLG, CREBBP, STAT3, HSP90AA1, EGF, RPS6KB1, MDM2, PRKCA, SRC, FGF2, UBC
TERTRUNX1No-12SP1, PTPN11, EP300, HDAC1, HDAC2, TP53, JUN, SMAD3, UBC, SIN3A, FOS, CREBBP
TERTNSD1No-1ESR1
TERTPICALMNo-1UBC
LPPKRASNo-1SPTA1
KRASETV6No-4UBC, MAPK1, NOTCH1, MAPK3
KRASDDX41No-5UBC, ERBB2, PTK2, PTPN11, BCL2
KRASKITYescatalysis, binding, activation25BCL2L1, BMP4, PTPN11, ETS2, SHC2, PIK3CG, NCAM1, FYN, ANGPT1, PIK3CA, SOS1, SHC1, HRAS, HSP90AA1, UBC, SHC3, PIK3CB, SRC, VEGFA, GRB2, YES1, RPS6KB1, IRS1, EGF, PIK3CD
KRASRUNX1No-9PTPN11, PRMT1, BMP4, TP53, JUN, MECOM, UBC, NCAM1, ETS1
KRASNSD1No-1BMP4
KRASPICALMNo-1UBC
ETV6DDX41No-1UBC
ETV6KITNo-1UBC
ETV6RUNX1No-4UBC, SIN3A, NCOR1, PDGFRB
ETV6PICALMNo-1UBC
DDX41KITNo-4UBC, INS, PTPN11, VAV1
DDX41RUNX1No-3UBC, PTPN11, FOS
DDX41PICALMNo-1UBC
KITRUNX1No-11CSF2, STAT5A, SPI1, BMP4, CREBBP, PTPN11, TAL1, STAT5B, DNMT1, UBC, NCAM1
KITNSD1No-1BMP4
KITPICALMNo-3EPS15, UBC, EPN1
RUNX1NSD1No-1BMP4
RUNX1PICALMNo-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
NPM1DDX41No-9SNU13, HNRNPR, HNRNPA1, PABPC1, HNRNPM, U2AF1, U2AF2, HNRNPU, DHX9
CBFBRUNX1YesRUNX1-CBF-beta-DNA complex0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
NUP214PICALMNo1EEF1A1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
CBFBRUNX1Yes2CBFB, RUNX1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Pathways in cancerhsa052003.985KIT, FLT3, RUNX1, KRAS, CEBPA
Acute myeloid leukemiahsa052216.745KIT, FLT3, RUNX1, KRAS, CEBPA
Transcriptional misregulation in cancerhsa052025.215ETV6, FLT3, RUNX1, CEBPA, MLF1
Central carbon metabolism in cancerhsa052306.73KIT, KRAS, FLT3
PI3K-Akt signaling pathwayhsa041514.213KIT, KRAS, JAK2
Lysine degradationhsa003107.012WHSC1L1, NSD1
Signaling pathways regulating pluripotency of stem cellshsa045505.62KRAS, JAK2
Dorso-ventral axis formationhsa043208.012ETV6, KRAS
Rap1 signaling pathwayhsa040154.972KIT, KRAS
Ras signaling pathwayhsa040144.92KIT, KRAS
Cholinergic synapsehsa047255.882KRAS, JAK2
Endocytosishsa041444.922SH3GL1, KIT
Hematopoietic cell lineagehsa046406.182KIT, FLT3
Chronic myeloid leukemiahsa052206.482RUNX1, KRAS
Melanogenesishsa049165.972KIT, KRAS
HTLV-I infectionhsa051664.592KRAS, TERT
Chemokine signaling pathwayhsa040625.192KRAS, JAK2
Cytokine-cytokine receptor interactionhsa040604.672KIT, FLT3
Prolactin signaling pathwayhsa049176.62KRAS, JAK2

NET-GE enrichment

Term New enriched termICP valueGenes
Cancers: OverviewNEW2.720.007PICALM, KRAS, KIT, CEBPA, GATA2, ETV6, LPP, JAK2, MLLT10, MLF1, FLT3, NPM1, RUNX1, NSD1
Cancers: Specific typesNEW4.10.005KRAS, KIT, CEBPA, GATA2, JAK2, ETV6, FLT3, NPM1, RUNX1
Central carbon metabolism in cancer (hsa05230) -6.70.022KIT, KRAS, FLT3
Acute myeloid leukemia (hsa05221) -6.740.0KIT, CEBPA, KRAS, JAK2, FLT3, RUNX1
Transcriptional misregulation in cancer (hsa05202) -5.210.001PICALM, CEBPA, GATA2, ETV6, JAK2, MLLT10, MLF1, FLT3, NPM1, RUNX1, NSD1
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.375JAK2, DDX41, KIT, KRAS, NUP214
Cytokine Signaling in Immune systemR-HSA-12802153.744JAK2, KIT, KRAS, NUP214
Signal TransductionR-HSA-1625821.784JAK2, KIT, TERT, KRAS
Innate Immune SystemR-HSA-1682493.174DDX41, KIT, JAK2, KRAS
DiseaseR-HSA-16436853.334KIT, KRAS, NUP214, NPM1
Developmental BiologyR-HSA-12667383.484KRAS, KIT, JAK2, CEBPA
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.853KIT, KRAS, JAK2
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.263KIT, KRAS, JAK2
NCAM signaling for neurite out-growthR-HSA-3751654.93KIT, KRAS, JAK2
Signaling by InterleukinsR-HSA-4491474.713KIT, JAK2, KRAS
Interleukin-2 signalingR-HSA-4519275.053KIT, KRAS, JAK2
Frs2-mediated activationR-HSA-1709685.123KIT, JAK2, KRAS
IRS-related events triggered by IGF1RR-HSA-24289284.853KIT, JAK2, KRAS
SOS-mediated signallingR-HSA-1124125.153KIT, JAK2, KRAS
IGF1R signaling cascadeR-HSA-24289244.853KIT, JAK2, KRAS
Downstream signal transductionR-HSA-1867634.653KIT, JAK2, KRAS
Cell CycleR-HSA-16401703.893TERT, NUP214, NPM1
Signaling by ERBB4R-HSA-12363944.73KIT, KRAS, JAK2
ARMS-mediated activationR-HSA-1709845.123KIT, JAK2, KRAS
Signaling by Insulin receptorR-HSA-747524.733KIT, JAK2, KRAS
RAF/MAP kinase cascadeR-HSA-56730015.153KIT, KRAS, JAK2
Downstream signaling of activated FGFR1R-HSA-56546874.713KIT, JAK2, KRAS
MAPK family signaling cascadesR-HSA-56830574.893KIT, KRAS, JAK2
Signalling by NGFR-HSA-1665204.233KIT, KRAS, JAK2
Signaling by VEGFR-HSA-1941384.663KIT, KRAS, JAK2
Signalling to p38 via RIT and RINR-HSA-1877065.123KIT, KRAS, JAK2
FCERI mediated MAPK activationR-HSA-28717964.323KIT, JAK2, KRAS
IRS-mediated signallingR-HSA-1123994.873KIT, KRAS, JAK2
FRS-mediated FGFR2 signalingR-HSA-56547005.143KIT, JAK2, KRAS
DAP12 interactionsR-HSA-21721274.563KIT, KRAS, JAK2
FRS-mediated FGFR3 signalingR-HSA-56547065.143KIT, JAK2, KRAS
Downstream signaling of activated FGFR3R-HSA-56547084.713KIT, JAK2, KRAS
Insulin receptor signalling cascadeR-HSA-747514.853KIT, KRAS, JAK2
Signaling by FGFR4R-HSA-56547434.693KIT, JAK2, KRAS
Signaling by FGFR3R-HSA-56547414.693KIT, KRAS, JAK2
VEGFA-VEGFR2 PathwayR-HSA-44200974.73KIT, JAK2, KRAS
GRB2 events in ERBB2 signalingR-HSA-19636405.153KIT, JAK2, KRAS
Signaling by FGFRR-HSA-1902364.673KIT, JAK2, KRAS
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.033KIT, KRAS, JAK2
Signaling by LeptinR-HSA-25865525.13KIT, KRAS, JAK2
MAPK1/MAPK3 signalingR-HSA-56849965.113KIT, JAK2, KRAS
Interleukin receptor SHC signalingR-HSA-9125265.093KIT, KRAS, JAK2
Signaling by SCF-KITR-HSA-14335574.733KIT, JAK2, KRAS
SHC1 events in ERBB2 signalingR-HSA-12501965.153KIT, KRAS, JAK2
Signaling by PDGFR-HSA-1867974.533KIT, JAK2, KRAS
Signalling to RASR-HSA-1670445.083KIT, KRAS, JAK2
DAP12 signalingR-HSA-24244914.643KIT, KRAS, JAK2
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.993KIT, JAK2, KRAS
Downstream signaling of activated FGFR2R-HSA-56546964.713KIT, KRAS, JAK2
SHC1 events in ERBB4 signalingR-HSA-12503475.153KIT, KRAS, JAK2
SHC1 events in EGFR signalingR-HSA-1803365.153KIT, KRAS, JAK2
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.513KIT, KRAS, JAK2
Chromatin modifying enzymesR-HSA-32475095.193WHSC1L1, JAK2, NSD1
Prolonged ERK activation eventsR-HSA-1698935.113KIT, JAK2, KRAS
Signalling to ERKsR-HSA-1876875.043KIT, JAK2, KRAS
Signaling by GPCRR-HSA-3727902.683KIT, JAK2, KRAS
Signaling by FGFR2R-HSA-56547384.683KIT, JAK2, KRAS
GRB2 events in EGFR signalingR-HSA-1798125.153KIT, JAK2, KRAS
Signaling by FGFR1R-HSA-56547364.693KIT, JAK2, KRAS
Signaling by EGFRR-HSA-1779294.593KIT, KRAS, JAK2
FRS-mediated FGFR1 signalingR-HSA-56546935.143KIT, KRAS, JAK2
FRS-mediated FGFR4 signalingR-HSA-56547125.143KIT, JAK2, KRAS
Chromatin organizationR-HSA-48397265.193WHSC1L1, JAK2, NSD1
Downstream signaling of activated FGFR4R-HSA-56547164.713KIT, JAK2, KRAS
Signaling by ERBB2R-HSA-12279864.663KIT, JAK2, KRAS
Axon guidanceR-HSA-4224753.933KIT, JAK2, KRAS
VEGFR2 mediated cell proliferationR-HSA-52189215.073KIT, JAK2, KRAS
HemostasisR-HSA-1095823.983GATA2, KRAS, JAK2
Infectious diseaseR-HSA-56632054.472NPM1, NUP214
Host Interactions of HIV factorsR-HSA-1629095.992NPM1, NUP214
Nuclear import of Rev proteinR-HSA-1807468.032NPM1, NUP214
Interactions of Rev with host cellular proteinsR-HSA-1772437.892NPM1, NUP214
Diseases of signal transductionR-HSA-56632024.892KIT, KRAS
Transmembrane transport of small moleculesR-HSA-3825513.792RUNX1, NUP214
HIV InfectionR-HSA-1629065.222NPM1, NUP214
SLC-mediated transmembrane transportR-HSA-4254074.952RUNX1, NUP214
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.622KIT, KRAS
PKMTs methylate histone lysinesR-HSA-32148417.662WHSC1L1, NSD1
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.592KIT, KRAS
Interferon SignalingR-HSA-9135314.952JAK2, NUP214
Chromosome MaintenanceR-HSA-738866.562NPM1, TERT
Factors involved in megakaryocyte development and platelet productionR-HSA-9832315.882GATA2, JAK2
Adaptive Immune SystemR-HSA-12802183.192KIT, KRAS
RAF activationR-HSA-56730008.342KRAS, JAK2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1823CBFB, NUP214, GATA2, CHIC2, JAK2, LPP, ETV6, RUNX1, CEBPA, TGM6, KRAS, MLLT10, KIT, FLT3, DDX41, NPM1, SETBP1, WHSC1L1, PICALM, MLF1, TERT, SH3GL1, NSD1
protein binding (GO:0005515) 0.4622CHIC2, NUP214, GATA2, CBFB, JAK2, LPP, MLF1, RUNX1, CEBPA, KRAS, MLLT10, KIT, FLT3, DDX41, NPM1, SETBP1, WHSC1L1, PICALM, ETV6, TERT, SH3GL1, NSD1
organic cyclic compound binding (GO:0097159) 1.0516CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, SETBP1, RUNX1, GATA2, NSD1
heterocyclic compound binding (GO:1901363) 1.0616CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, SETBP1, RUNX1, GATA2, NSD1
cation binding (GO:0043169) 1.412KRAS, KIT, GATA2, TGM6, JAK2, LPP, MLLT10, NSD1, TERT, RUNX1, DDX41, WHSC1L1
metal ion binding (GO:0046872) 1.4112KRAS, KIT, GATA2, TGM6, JAK2, LPP, MLLT10, NSD1, TERT, RUNX1, DDX41, WHSC1L1
nucleic acid binding (GO:0003676) 1.4412CBFB, CEBPA, GATA2, ETV6, MLLT10, MLF1, TERT, NPM1, SETBP1, RUNX1, DDX41, NSD1
ion binding (GO:0043167) 1.3612KRAS, KIT, GATA2, TGM6, JAK2, LPP, MLLT10, NSD1, TERT, RUNX1, DDX41, WHSC1L1
DNA binding (GO:0003677) 1.9211CBFB, CEBPA, DDX41, ETV6, MLLT10, MLF1, TERT, SETBP1, RUNX1, GATA2, NSD1
catalytic activity (GO:0003824) 1.0510KRAS, KIT, FLT3, TGM6, JAK2, NSD1, TERT, RUNX1, DDX41, WHSC1L1
transferase activity (GO:0016740) 1.957KIT, FLT3, TGM6, JAK2, WHSC1L1, TERT, NSD1
identical protein binding (GO:0042802) 2.637KIT, FLT3, CEBPA, NPM1, TERT, SH3GL1, RUNX1
sequence-specific DNA binding (GO:0043565) 2.796CEBPA, GATA2, ETV6, TERT, RUNX1, NSD1
purine ribonucleoside triphosphate binding (GO:0035639) 2.226KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
transcription factor binding (GO:0008134) 3.466CEBPA, GATA2, NPM1, TERT, RUNX1, NSD1
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.656CBFB, CEBPA, GATA2, ETV6, MLLT10, RUNX1
nucleotide binding (GO:0000166) 1.966KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
small molecule binding (GO:0036094) 1.896KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
carbohydrate derivative binding (GO:0097367) 2.036KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
ribonucleotide binding (GO:0032553) 2.196KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
nucleic acid binding transcription factor activity (GO:0001071) 2.656CBFB, CEBPA, GATA2, ETV6, MLLT10, RUNX1
purine nucleoside binding (GO:0001883) 2.226KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
ribonucleoside binding (GO:0032549) 2.226KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
purine ribonucleotide binding (GO:0032555) 2.26KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
purine nucleotide binding (GO:0017076) 2.196KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
protein dimerization activity (GO:0046983) 2.726KIT, TERT, CEBPA, NPM1, FLT3, RUNX1
nucleoside binding (GO:0001882) 2.216KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
purine ribonucleoside binding (GO:0032550) 2.226KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
nucleoside phosphate binding (GO:1901265) 1.966KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
protein homodimerization activity (GO:0042803) 3.166KIT, TERT, CEBPA, NPM1, FLT3, RUNX1
transcription regulatory region DNA binding (GO:0044212) 3.035ETV6, GATA2, RUNX1, CEBPA, NSD1
sequence-specific double-stranded DNA binding (GO:1990837) 3.25ETV6, GATA2, RUNX1, CEBPA, NSD1
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.245ETV6, GATA2, RUNX1, CEBPA, NSD1
transition metal ion binding (GO:0046914) 2.485LPP, GATA2, WHSC1L1, MLLT10, NSD1
adenyl nucleotide binding (GO:0030554) 2.45KIT, DDX41, RUNX1, FLT3, JAK2
regulatory region nucleic acid binding (GO:0001067) 3.035ETV6, GATA2, RUNX1, CEBPA, NSD1
regulatory region DNA binding (GO:0000975) 3.035ETV6, GATA2, RUNX1, CEBPA, NSD1
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.365ETV6, GATA2, RUNX1, CEBPA, NSD1
transcription cofactor activity (GO:0003712) 3.445CBFB, RUNX1, CEBPA, NSD1, NPM1
enzyme binding (GO:0019899) 2.275SH3GL1, KIT, JAK2, CEBPA, NPM1
protein domain specific binding (GO:0019904) 3.325ETV6, GATA2, KRAS, JAK2, MLF1
macromolecular complex binding (GO:0044877) 2.615KRAS, GATA2, FLT3, NPM1, NSD1
zinc ion binding (GO:0008270) 2.665LPP, GATA2, MLLT10, WHSC1L1, NSD1
transcription factor activity, transcription factor binding (GO:0000989) 3.365CBFB, RUNX1, CEBPA, NSD1, NPM1
transcription factor activity, protein binding (GO:0000988) 3.355CBFB, RUNX1, CEBPA, NSD1, NPM1
adenyl ribonucleotide binding (GO:0032559) 2.415KIT, DDX41, RUNX1, FLT3, JAK2
double-stranded DNA binding (GO:0003690) 3.095ETV6, GATA2, RUNX1, CEBPA, NSD1
ATP binding (GO:0005524) 2.435KIT, DDX41, RUNX1, FLT3, JAK2
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.375ETV6, GATA2, RUNX1, CEBPA, NSD1
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.774FLT3, KIT, JAK2, TERT
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.984GATA2, RUNX1, ETV6, CEBPA
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.294GATA2, RUNX1, ETV6, CEBPA
hydrolase activity (GO:0016787) 1.93DDX41, RUNX1, KRAS
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.083KIT, FLT3, JAK2
kinase activity (GO:0016301) 2.933KIT, FLT3, JAK2
transcription coactivator activity (GO:0003713) 4.043CBFB, NPM1, CEBPA
kinase binding (GO:0019900) 3.323CEBPA, JAK2, NPM1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077) 4.313GATA2, ETV6, CEBPA
protein tyrosine kinase activity (GO:0004713) 4.543KIT, FLT3, JAK2
core promoter binding (GO:0001047) 4.713GATA2, RUNX1, NSD1
protein kinase activity (GO:0004672) 3.273KIT, FLT3, JAK2
hormone receptor binding (GO:0051427) 4.573FLT3, JAK2, NSD1
receptor binding (GO:0005102) 2.433FLT3, JAK2, NSD1
molecular function regulator (GO:0098772) 2.513KIT, NPM1, JAK2
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982) 3.943GATA2, ETV6, CEBPA
RNA binding (GO:0003723) 2.363DDX41, NPM1, TERT
Ras guanyl-nucleotide exchange factor activity (GO:0005088) 4.312KIT, JAK2
histone binding (GO:0042393) 4.722JAK2, NPM1
histone methyltransferase activity (GO:0042054) 5.682WHSC1L1, NSD1
histone-lysine N-methyltransferase activity (GO:0018024) 5.932WHSC1L1, NSD1
guanyl-nucleotide exchange factor activity (GO:0005085) 4.022KIT, JAK2
lysine N-methyltransferase activity (GO:0016278) 5.72WHSC1L1, NSD1
protein-lysine N-methyltransferase activity (GO:0016279) 5.712WHSC1L1, NSD1
molecular transducer activity (GO:0060089) 2.322KIT, FLT3
protein methyltransferase activity (GO:0008276) 5.332WHSC1L1, NSD1
receptor activity (GO:0004872) 2.322KIT, FLT3
signal transducer activity (GO:0004871) 2.282KIT, FLT3
methyltransferase activity (GO:0008168) 4.352WHSC1L1, NSD1
transcription corepressor activity (GO:0003714) 4.332RUNX1, NSD1
transmembrane receptor protein tyrosine kinase activity (GO:0004714) 5.552KIT, FLT3
transferase activity, transferring one-carbon groups (GO:0016741) 4.32WHSC1L1, NSD1
RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979) 5.772GATA2, NSD1
core promoter proximal region sequence-specific DNA binding (GO:0000987) 3.832ETV6, CEBPA
steroid hormone receptor binding (GO:0035258) 5.322FLT3, NSD1
S-adenosylmethionine-dependent methyltransferase activity (GO:0008757) 4.812WHSC1L1, NSD1
poly(A) RNA binding (GO:0044822) 2.692DDX41, NPM1
nuclear hormone receptor binding (GO:0035257) 4.72FLT3, NSD1
lipid binding (GO:0008289) 3.262SH3GL1, PICALM
nucleoside-triphosphatase activity (GO:0017111) 3.092DDX41, KRAS
protein kinase binding (GO:0019901) 3.442JAK2, NPM1
protein complex binding (GO:0032403) 3.092KRAS, FLT3
N-methyltransferase activity (GO:0008170) 5.262WHSC1L1, NSD1
core promoter proximal region DNA binding (GO:0001159) 3.822ETV6, CEBPA
core promoter sequence-specific DNA binding (GO:0001046) 5.122GATA2, NSD1
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) 3.882ETV6, CEBPA
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032DDX41, KRAS
chromatin binding (GO:0003682) 3.642GATA2, NSD1
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032DDX41, KRAS
transmembrane receptor protein kinase activity (GO:0019199) 5.322KIT, FLT3
pyrophosphatase activity (GO:0016462) 3.042DDX41, KRAS
transmembrane signaling receptor activity (GO:0004888) 2.572KIT, FLT3
signaling receptor activity (GO:0038023) 2.492KIT, FLT3
protein heterodimerization activity (GO:0046982) 3.642RUNX1, NPM1
transmembrane receptor activity (GO:0099600) 2.532KIT, FLT3

NET-GE enrichment

Term New enriched termICP valueGenes
RNA polymerase II regulatory region DNA binding (GO:0001012) -3.360.024CEBPA, GATA2, ETV6, NPM1, FLT3, RUNX1, NSD1
core promoter proximal region DNA binding (GO:0001159) -3.820.015CEBPA, GATA2, ETV6, FLT3, RUNX1, NSD1
enhancer sequence-specific DNA binding (GO:0001158) NEW5.360.021GATA2, RUNX1, NPM1, JAK2
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077) -4.310.0CEBPA, GATA2, ETV6, NPM1, FLT3, RUNX1, NSD1
DNA binding (GO:0003677) -1.920.0CHIC2, KRAS, KIT, FLT3, CEBPA, NSD1, DDX41, CBFB, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, SETBP1, RUNX1, GATA2, WHSC1L1
sequence-specific DNA binding (GO:0043565) -2.790.024KRAS, FLT3, CEBPA, GATA2, JAK2, ETV6, TERT, NPM1, RUNX1, NSD1
identical protein binding (GO:0042802) -2.630.046KIT, FLT3, CEBPA, NPM1, TERT, SH3GL1, RUNX1
core promoter proximal region sequence-specific DNA binding (GO:0000987) -3.830.015CEBPA, GATA2, ETV6, FLT3, RUNX1, NSD1
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity (GO:0000982) -3.940.004CEBPA, GATA2, ETV6, NPM1, FLT3, RUNX1, NSD1
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) -3.290.02CEBPA, GATA2, JAK2, ETV6, FLT3, NPM1, RUNX1, NSD1
protein homodimerization activity (GO:0042803) -3.160.021KIT, TERT, CEBPA, NPM1, FLT3, RUNX1
transcription factor binding (GO:0008134) -3.460.043GATA2, RUNX1, CEBPA, NSD1, NPM1
regulatory region nucleic acid binding (GO:0001067) -3.030.011FLT3, CEBPA, GATA2, JAK2, ETV6, TERT, NPM1, RUNX1, NSD1
enhancer binding (GO:0035326) NEW5.210.047GATA2, RUNX1, NPM1, JAK2
transcription regulatory region DNA binding (GO:0044212) -3.030.01FLT3, CEBPA, GATA2, JAK2, ETV6, TERT, NPM1, RUNX1, NSD1
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228) -3.980.003CEBPA, GATA2, ETV6, NPM1, FLT3, RUNX1, NSD1
transcription regulatory region sequence-specific DNA binding (GO:0000976) -3.240.006CEBPA, GATA2, JAK2, ETV6, FLT3, NPM1, RUNX1, NSD1
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) -3.370.024CEBPA, GATA2, ETV6, NPM1, FLT3, RUNX1, NSD1
protein binding (GO:0005515) -0.460.002CHIC2, KRAS, WHSC1L1, TERT, CEBPA, DDX41, NUP214, CBFB, ETV6, LPP, JAK2, MLLT10, MLF1, FLT3, NPM1, PICALM, KIT, SH3GL1, RUNX1, GATA2, NSD1
regulatory region DNA binding (GO:0000975) -3.030.011FLT3, CEBPA, GATA2, JAK2, ETV6, TERT, NPM1, RUNX1, NSD1
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978) -3.880.013CEBPA, GATA2, ETV6, FLT3, RUNX1, NSD1
protein domain specific binding (GO:0019904) -3.320.012PICALM, KRAS, KIT, FLT3, CEBPA, GATA2, ETV6, LPP, JAK2, MLF1, TERT, RUNX1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular macromolecule metabolic process (GO:0044260) 0.9319NSD1, KRAS, KIT, NUP214, CEBPA, RUNX1, GATA2, CBFB, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, FLT3, DDX41, TGM6, WHSC1L1
cellular process (GO:0009987) 0.2619CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, RUNX1, TGM6, WHSC1L1
cellular metabolic process (GO:0044237) 0.6919NSD1, KRAS, KIT, NUP214, CEBPA, RUNX1, GATA2, CBFB, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, FLT3, DDX41, TGM6, WHSC1L1
regulation of cellular process (GO:0050794) 0.519CBFB, KRAS, KIT, NUP214, CEBPA, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, SH3GL1, RUNX1, GATA2, WHSC1L1
organic substance metabolic process (GO:0071704) 0.6319CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, RUNX1, TGM6, WHSC1L1
biological regulation (GO:0065007) 0.3919CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, FLT3, ETV6, JAK2, MLLT10, WHSC1L1, MLF1, TERT, NPM1, PICALM, SH3GL1, RUNX1, DDX41, NSD1
metabolic process (GO:0008152) 0.5819CBFB, KRAS, KIT, NUP214, CEBPA, RUNX1, GATA2, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, NSD1, DDX41, TGM6, WHSC1L1
macromolecule metabolic process (GO:0043170) 0.8319CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, DDX41, FLT3, ETV6, JAK2, MLLT10, WHSC1L1, MLF1, TERT, NPM1, PICALM, RUNX1, TGM6, NSD1
regulation of biological process (GO:0050789) 0.4519CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, FLT3, ETV6, JAK2, MLLT10, WHSC1L1, MLF1, TERT, NPM1, PICALM, SH3GL1, RUNX1, DDX41, NSD1
primary metabolic process (GO:0044238) 0.6918CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, NSD1, TGM6, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of macromolecule metabolic process (GO:0060255) 1.0817CBFB, KRAS, KIT, NUP214, CEBPA, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, NPM1, TERT, PICALM, RUNX1, GATA2, WHSC1L1
regulation of metabolic process (GO:0019222) 1.0217CBFB, KRAS, KIT, NUP214, CEBPA, NSD1, GATA2, FLT3, ETV6, MLLT10, JAK2, TERT, NPM1, PICALM, RUNX1, DDX41, WHSC1L1
regulation of cellular metabolic process (GO:0031323) 1.0716CBFB, KRAS, KIT, FLT3, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of primary metabolic process (GO:0080090) 1.0816CBFB, KRAS, KIT, FLT3, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of gene expression (GO:0010468) 1.3716CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, PICALM, ETV6, JAK2, MLLT10, NSD1, TERT, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of metabolic process (GO:0009893) 1.7415CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, NSD1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.4315CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, WHSC1L1
regulation of biosynthetic process (GO:0009889) 1.3715CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, WHSC1L1
positive regulation of cellular metabolic process (GO:0031325) 1.8115CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, NSD1
regulation of RNA metabolic process (GO:0051252) 1.5215CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, WHSC1L1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.4615CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of macromolecule metabolic process (GO:0010604) 1.8115CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
regulation of nucleic acid-templated transcription (GO:1903506) 1.5515CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of cellular biosynthetic process (GO:0031326) 1.3815CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, WHSC1L1
regulation of transcription, DNA-templated (GO:0006355) 1.5615CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of macromolecule biosynthetic process (GO:0010556) 1.4315CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
single-organism cellular process (GO:0044763) 0.6515CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, FLT3, ETV6, JAK2, MLF1, TERT, NPM1, PICALM, RUNX1, DDX41
regulation of nitrogen compound metabolic process (GO:0051171) 1.3615CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of RNA biosynthetic process (GO:2001141) 1.5515CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, WHSC1L1
positive regulation of biological process (GO:0048518) 1.215CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
single-organism process (GO:0044699) 0.4815CBFB, KRAS, KIT, NUP214, CEBPA, DDX41, FLT3, ETV6, JAK2, MLF1, TERT, NPM1, PICALM, RUNX1, GATA2
positive regulation of cellular process (GO:0048522) 1.315CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
developmental process (GO:0032502) 1.3614CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, PICALM, MLF1, JAK2, TERT, NPM1, SH3GL1, RUNX1, DDX41
nitrogen compound metabolic process (GO:0006807) 1.1314CBFB, KIT, NUP214, CEBPA, NSD1, DDX41, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, GATA2, WHSC1L1
nucleobase-containing compound metabolic process (GO:0006139) 1.3513CBFB, NUP214, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, DDX41, WHSC1L1
nucleic acid metabolic process (GO:0090304) 1.4613CBFB, NUP214, CEBPA, NSD1, DDX41, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, GATA2, WHSC1L1
cellular aromatic compound metabolic process (GO:0006725) 1.313CBFB, NUP214, CEBPA, NSD1, DDX41, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, GATA2, WHSC1L1
single-organism developmental process (GO:0044767) 1.4913CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, PICALM, MLF1, JAK2, TERT, NPM1, RUNX1, DDX41
cellular nitrogen compound metabolic process (GO:0034641) 1.2213CBFB, NUP214, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of gene expression (GO:0010628) 2.3513CBFB, KRAS, KIT, CEBPA, DDX41, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
negative regulation of biological process (GO:0048519) 1.3313PICALM, KRAS, KIT, NUP214, CEBPA, GATA2, ETV6, JAK2, MLF1, TERT, NPM1, RUNX1, NSD1
organic cyclic compound metabolic process (GO:1901360) 1.2613CBFB, NUP214, CEBPA, NSD1, DDX41, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, GATA2, WHSC1L1
heterocycle metabolic process (GO:0046483) 1.3113CBFB, NUP214, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, DDX41, WHSC1L1
RNA metabolic process (GO:0016070) 1.5912CBFB, NUP214, CEBPA, NSD1, DDX41, ETV6, MLLT10, MLF1, TERT, RUNX1, GATA2, WHSC1L1
positive regulation of biosynthetic process (GO:0009891) 2.2912CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
cellular developmental process (GO:0048869) 1.8212CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, ETV6, JAK2, MLF1, TERT, NPM1, RUNX1
positive regulation of cellular biosynthetic process (GO:0031328) 2.312CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.3912CBFB, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, NSD1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.2912CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
negative regulation of cellular process (GO:0048523) 1.4112PICALM, KRAS, KIT, CEBPA, GATA2, ETV6, JAK2, MLF1, TERT, NPM1, RUNX1, NSD1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.5611CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
organic substance biosynthetic process (GO:1901576) 1.3411CBFB, CEBPA, NUP214, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.3511CBFB, CEBPA, GATA2, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, DDX41, NSD1
RNA biosynthetic process (GO:0032774) 1.8411CBFB, NUP214, CEBPA, GATA2, ETV6, MLF1, MLLT10, WHSC1L1, TERT, RUNX1, NSD1
anatomical structure development (GO:0048856) 1.5811CBFB, KRAS, KIT, CEBPA, DDX41, MLF1, JAK2, FLT3, SH3GL1, RUNX1, GATA2
positive regulation of RNA metabolic process (GO:0051254) 2.5111CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
positive regulation of RNA biosynthetic process (GO:1902680) 2.5411CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
cellular biosynthetic process (GO:0044249) 1.3711CBFB, CEBPA, NUP214, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
biosynthetic process (GO:0009058) 1.3211CBFB, WHSC1L1, NUP214, CEBPA, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, NSD1
macromolecule biosynthetic process (GO:0009059) 1.6111CBFB, CEBPA, NUP214, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
positive regulation of transcription, DNA-templated (GO:0045893) 2.5611CBFB, CEBPA, GATA2, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, DDX41, NSD1
aromatic compound biosynthetic process (GO:0019438) 1.711CBFB, NUP214, CEBPA, GATA2, ETV6, MLF1, MLLT10, WHSC1L1, TERT, RUNX1, NSD1
nucleobase-containing compound biosynthetic process (GO:0034654) 1.7211CBFB, NUP214, CEBPA, GATA2, ETV6, MLF1, MLLT10, WHSC1L1, TERT, RUNX1, NSD1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.5911CBFB, NUP214, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
organic cyclic compound biosynthetic process (GO:1901362) 1.6611CBFB, WHSC1L1, NUP214, CEBPA, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, NSD1
heterocycle biosynthetic process (GO:0018130) 1.711CBFB, NUP214, CEBPA, GATA2, ETV6, MLF1, MLLT10, WHSC1L1, TERT, RUNX1, NSD1
cellular macromolecule biosynthetic process (GO:0034645) 1.6610CBFB, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
cell differentiation (GO:0030154) 2.1410CBFB, KRAS, KIT, CEBPA, GATA2, ETV6, JAK2, MLF1, FLT3, RUNX1
nucleic acid-templated transcription (GO:0097659) 1.9110CBFB, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
cellular component organization or biogenesis (GO:0071840) 1.2210PICALM, KRAS, KIT, CEBPA, NUP214, JAK2, WHSC1L1, TERT, NPM1, NSD1
cellular component organization (GO:0016043) 1.2410PICALM, KRAS, KIT, CEBPA, NUP214, JAK2, WHSC1L1, TERT, NPM1, NSD1
cellular protein metabolic process (GO:0044267) 1.639CBFB, KRAS, KIT, NUP214, TGM6, JAK2, NSD1, FLT3, WHSC1L1
regulation of cellular protein metabolic process (GO:0032268) 1.999PICALM, KRAS, KIT, CEBPA, GATA2, JAK2, NPM1, FLT3, NSD1
negative regulation of metabolic process (GO:0009892) 1.939PICALM, CEBPA, NUP214, GATA2, ETV6, NPM1, TERT, RUNX1, NSD1
regulation of biological quality (GO:0065008) 1.689PICALM, KIT, CEBPA, NUP214, GATA2, FLT3, JAK2, KRAS, TERT
single-multicellular organism process (GO:0044707) 1.789CBFB, KRAS, KIT, CEBPA, DDX41, MLF1, JAK2, RUNX1, GATA2
protein metabolic process (GO:0019538) 1.459CBFB, KRAS, KIT, NUP214, TGM6, JAK2, NSD1, FLT3, WHSC1L1
response to stimulus (GO:0050896) 1.229KRAS, KIT, FLT3, CEBPA, DDX41, JAK2, NPM1, TERT, GATA2
regulation of protein metabolic process (GO:0051246) 1.939PICALM, KRAS, KIT, CEBPA, GATA2, JAK2, NPM1, FLT3, NSD1
cellular protein modification process (GO:0006464) 1.799CBFB, KRAS, KIT, NUP214, TGM6, JAK2, WHSC1L1, FLT3, NSD1
macromolecule modification (GO:0043412) 1.739CBFB, KRAS, KIT, NUP214, TGM6, JAK2, NSD1, FLT3, WHSC1L1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.249CBFB, CEBPA, DDX41, ETV6, MLLT10, TERT, RUNX1, GATA2, NSD1
transcription, DNA-templated (GO:0006351) 1.919CBFB, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, RUNX1, WHSC1L1
protein modification process (GO:0036211) 1.799CBFB, KRAS, KIT, NUP214, TGM6, JAK2, NSD1, FLT3, WHSC1L1
negative regulation of macromolecule metabolic process (GO:0010605) 2.019PICALM, CEBPA, NUP214, GATA2, ETV6, NPM1, TERT, RUNX1, NSD1
regulation of molecular function (GO:0065009) 1.789PICALM, KRAS, KIT, FLT3, CEBPA, JAK2, NPM1, TERT, NSD1
establishment of localization (GO:0051234) 1.489CHIC2, KIT, NUP214, GATA2, PICALM, JAK2, NPM1, TERT, SH3GL1
localization (GO:0051179) 1.49CHIC2, KIT, NUP214, GATA2, PICALM, JAK2, NPM1, TERT, SH3GL1
multicellular organismal process (GO:0032501) 1.459CBFB, KRAS, KIT, CEBPA, DDX41, MLF1, JAK2, RUNX1, GATA2
regulation of cell proliferation (GO:0042127) 2.418KRAS, KIT, FLT3, CEBPA, GATA2, JAK2, NPM1, TERT
transport (GO:0006810) 1.518CHIC2, KIT, NUP214, GATA2, PICALM, JAK2, NPM1, SH3GL1
regulation of catalytic activity (GO:0050790) 1.978PICALM, KRAS, KIT, FLT3, CEBPA, JAK2, NPM1, TERT
regulation of response to stimulus (GO:0048583) 1.548KRAS, KIT, FLT3, NUP214, GATA2, JAK2, NPM1, TERT
negative regulation of gene expression (GO:0010629) 2.488PICALM, CEBPA, NUP214, GATA2, ETV6, TERT, RUNX1, NSD1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.818CBFB, CEBPA, DDX41, ETV6, MLLT10, TERT, RUNX1, GATA2
signal transduction (GO:0007165) 1.288KRAS, KIT, CEBPA, JAK2, NPM1, FLT3, SH3GL1, RUNX1
regulation of protein modification process (GO:0031399) 2.328KRAS, KIT, CEBPA, GATA2, JAK2, NPM1, FLT3, NSD1
response to chemical (GO:0042221) 1.988KIT, FLT3, CEBPA, GATA2, JAK2, KRAS, TERT, DDX41
negative regulation of cellular metabolic process (GO:0031324) 2.018PICALM, CEBPA, GATA2, ETV6, NPM1, TERT, RUNX1, NSD1
regulation of phosphorylation (GO:0042325) 2.57KRAS, KIT, CEBPA, JAK2, NPM1, FLT3, NSD1
regulation of phosphorus metabolic process (GO:0051174) 2.357KRAS, KIT, CEBPA, JAK2, NPM1, FLT3, NSD1
cellular response to stimulus (GO:0051716) 1.977KIT, FLT3, CEBPA, DDX41, JAK2, NPM1, TERT
regulation of protein phosphorylation (GO:0001932) 2.577KRAS, KIT, CEBPA, JAK2, NPM1, FLT3, NSD1
regulation of phosphate metabolic process (GO:0019220) 2.357KRAS, KIT, CEBPA, JAK2, NPM1, FLT3, NSD1
positive regulation of molecular function (GO:0044093) 2.237PICALM, KRAS, KIT, TERT, JAK2, NPM1, FLT3
immune system process (GO:0002376) 2.297CBFB, KIT, GATA2, JAK2, KRAS, FLT3, DDX41
positive regulation of multicellular organismal process (GO:0051240) 2.497KIT, CEBPA, DDX41, JAK2, TERT, RUNX1, GATA2
positive regulation of protein metabolic process (GO:0051247) 2.437PICALM, KRAS, KIT, CEBPA, JAK2, NPM1, FLT3
homeostatic process (GO:0042592) 2.617PICALM, FLT3, CEBPA, GATA2, JAK2, KRAS, TERT
positive regulation of cellular protein metabolic process (GO:0032270) 2.497PICALM, KRAS, KIT, CEBPA, JAK2, NPM1, FLT3
regulation of multicellular organismal process (GO:0051239) 1.877KIT, CEBPA, DDX41, JAK2, TERT, RUNX1, GATA2
regulation of cell death (GO:0010941) 2.437PICALM, KRAS, KIT, TERT, JAK2, NPM1, FLT3
response to organic substance (GO:0010033) 2.27KIT, CEBPA, GATA2, JAK2, KRAS, FLT3, DDX41
positive regulation of cell proliferation (GO:0008284) 3.016KIT, TERT, KRAS, JAK2, FLT3, NPM1
organelle organization (GO:0006996) 2.026PICALM, KIT, CEBPA, KRAS, NPM1, TERT
regulation of kinase activity (GO:0043549) 3.076KIT, CEBPA, KRAS, JAK2, FLT3, NPM1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.556CEBPA, GATA2, ETV6, TERT, RUNX1, NSD1
macromolecular complex subunit organization (GO:0043933) 2.146PICALM, JAK2, WHSC1L1, TERT, NPM1, NSD1
negative regulation of RNA metabolic process (GO:0051253) 2.666CEBPA, GATA2, ETV6, TERT, RUNX1, NSD1
regulation of protein kinase activity (GO:0045859) 3.156KIT, CEBPA, KRAS, JAK2, FLT3, NPM1
regulation of cell differentiation (GO:0045595) 2.426KIT, CEBPA, GATA2, KRAS, JAK2, RUNX1
regulation of transferase activity (GO:0051338) 2.886KIT, CEBPA, KRAS, JAK2, FLT3, NPM1
regulation of signal transduction (GO:0009966) 1.846KIT, TERT, GATA2, KRAS, JAK2, FLT3
regulation of programmed cell death (GO:0043067) 2.496KIT, TERT, KRAS, JAK2, FLT3, NPM1
animal organ development (GO:0048513) 2.536CBFB, KIT, CEBPA, GATA2, FLT3, RUNX1
peptidyl-amino acid modification (GO:0018193) 2.986KIT, NUP214, JAK2, WHSC1L1, FLT3, NSD1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.476CEBPA, GATA2, ETV6, TERT, RUNX1, NSD1
regulation of signaling (GO:0023051) 1.726KIT, TERT, GATA2, KRAS, JAK2, FLT3
regulation of localization (GO:0032879) 1.946PICALM, KIT, NUP214, GATA2, JAK2, TERT
regulation of cell communication (GO:0010646) 1.736KIT, TERT, GATA2, KRAS, JAK2, FLT3
positive regulation of catalytic activity (GO:0043085) 2.46PICALM, KIT, TERT, KRAS, JAK2, FLT3
cellular component assembly (GO:0022607) 2.145JAK2, PICALM, KIT, TERT, NPM1
cytokine-mediated signaling pathway (GO:0019221) 3.65JAK2, FLT3, KIT, KRAS, CEBPA
negative regulation of biosynthetic process (GO:0009890) 2.475ETV6, GATA2, RUNX1, CEBPA, NSD1
negative regulation of cellular biosynthetic process (GO:0031327) 2.495ETV6, GATA2, RUNX1, CEBPA, NSD1
positive regulation of response to stimulus (GO:0048584) 2.185TERT, FLT3, KIT, JAK2, KRAS
regulation of cellular component organization (GO:0051128) 2.015PICALM, GATA2, KIT, NPM1, NSD1
positive regulation of signaling (GO:0023056) 2.415KRAS, FLT3, KIT, JAK2, TERT
cellular response to chemical stimulus (GO:0070887) 2.575DDX41, FLT3, KIT, TERT, CEBPA
positive regulation of cell communication (GO:0010647) 2.415KRAS, FLT3, KIT, JAK2, TERT
regulation of protein serine/threonine kinase activity (GO:0071900) 3.585KRAS, FLT3, KIT, JAK2, CEBPA
regulation of apoptotic process (GO:0042981) 2.55KRAS, FLT3, TERT, JAK2, NPM1
single-organism metabolic process (GO:0044710) 1.635PICALM, KRAS, KIT, JAK2, CEBPA
positive regulation of signal transduction (GO:0009967) 2.55JAK2, FLT3, KIT, TERT, KRAS
cell surface receptor signaling pathway (GO:0007166) 2.095KRAS, FLT3, KIT, JAK2, CEBPA
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.65ETV6, GATA2, RUNX1, CEBPA, NSD1
regulation of immune system process (GO:0002682) 2.55RUNX1, GATA2, KIT, KRAS, JAK2
transcription from RNA polymerase II promoter (GO:0006366) 3.385ETV6, CBFB, RUNX1, GATA2, CEBPA
hematopoietic or lymphoid organ development (GO:0048534) 4.495KIT, CBFB, RUNX1, GATA2, FLT3
cellular localization (GO:0051641) 2.325JAK2, GATA2, KIT, NPM1, NUP214
negative regulation of programmed cell death (GO:0043069) 3.025TERT, KIT, KRAS, JAK2, NPM1
cell proliferation (GO:0008283) 3.235RUNX1, PICALM, KIT, ETV6, FLT3
negative regulation of cell death (GO:0060548) 2.955JAK2, KRAS, KIT, TERT, NPM1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.715ETV6, GATA2, RUNX1, CEBPA, NSD1
positive regulation of cell differentiation (GO:0045597) 3.015KIT, GATA2, RUNX1, CEBPA, JAK2
single-organism transport (GO:0044765) 2.185PICALM, GATA2, KIT, JAK2, NUP214
negative regulation of transcription, DNA-templated (GO:0045892) 2.755ETV6, GATA2, RUNX1, CEBPA, NSD1
establishment of localization in cell (GO:0051649) 2.475GATA2, KIT, JAK2, NUP214, NPM1
single-organism localization (GO:1902578) 2.095PICALM, GATA2, KIT, JAK2, NUP214
multi-organism process (GO:0051704) 2.655DDX41, KRAS, CEBPA, NUP214, NPM1
negative regulation of RNA biosynthetic process (GO:1902679) 2.75ETV6, GATA2, RUNX1, CEBPA, NSD1
vesicle-mediated transport (GO:0016192) 2.725PICALM, CHIC2, KIT, SH3GL1, GATA2
intracellular transport (GO:0046907) 2.675JAK2, GATA2, KIT, NPM1, NUP214
regulation of response to stress (GO:0080134) 2.535TERT, KRAS, JAK2, NUP214, NPM1
response to stress (GO:0006950) 1.85JAK2, DDX41, KIT, TERT, NPM1
myeloid cell differentiation (GO:0030099) 4.635KIT, CBFB, RUNX1, JAK2, CEBPA
hemopoiesis (GO:0030097) 5.075KIT, CBFB, RUNX1, GATA2, FLT3
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.535ETV6, GATA2, RUNX1, CEBPA, NSD1
positive regulation of kinase activity (GO:0033674) 3.544KRAS, KIT, FLT3, JAK2
regulation of transport (GO:0051049) 2.244PICALM, GATA2, JAK2, NUP214
cell motility (GO:0048870) 3.024GATA2, KIT, KRAS, JAK2
cell development (GO:0048468) 3.284KIT, GATA2, RUNX1, KRAS
movement of cell or subcellular component (GO:0006928) 2.614GATA2, KIT, KRAS, JAK2
leukocyte activation (GO:0045321) 3.764CBFB, KIT, GATA2, FLT3
regulation of MAP kinase activity (GO:0043405) 3.954KRAS, KIT, FLT3, JAK2
enzyme linked receptor protein signaling pathway (GO:0007167) 3.244KRAS, KIT, FLT3, JAK2
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.544KRAS, KIT, FLT3, JAK2
intracellular signal transduction (GO:0035556) 2.394KRAS, KIT, JAK2, NPM1
developmental maturation (GO:0021700) 4.74PICALM, CBFB, GATA2, CEBPA
regulation of MAPK cascade (GO:0043408) 3.224FLT3, KIT, JAK2, KRAS
interspecies interaction between organisms (GO:0044419) 3.084DDX41, CEBPA, NUP214, NPM1
positive regulation of transferase activity (GO:0051347) 3.314FLT3, KIT, JAK2, KRAS
protein complex subunit organization (GO:0071822) 2.64PICALM, TERT, JAK2, NPM1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.124ETV6, GATA2, CEBPA, NSD1
chromatin organization (GO:0006325) 3.284WHSC1L1, JAK2, NSD1, NPM1
response to lipid (GO:0033993) 3.114GATA2, KRAS, FLT3, JAK2
positive regulation of phosphorus metabolic process (GO:0010562) 2.784FLT3, KIT, JAK2, KRAS
positive regulation of protein kinase activity (GO:0045860) 3.614FLT3, KIT, JAK2, KRAS
macromolecular complex assembly (GO:0065003) 2.554PICALM, TERT, JAK2, NPM1
cellular response to organic substance (GO:0071310) 2.784DDX41, KIT, FLT3, CEBPA
negative regulation of apoptotic process (GO:0043066) 3.044KRAS, TERT, JAK2, NPM1
negative regulation of molecular function (GO:0044092) 2.744JAK2, PICALM, CEBPA, NPM1
cell migration (GO:0016477) 3.124GATA2, KIT, KRAS, JAK2
negative regulation of cell proliferation (GO:0008285) 3.264JAK2, GATA2, CEBPA, NPM1
protein phosphorylation (GO:0006468) 2.894FLT3, KIT, JAK2, KRAS
positive regulation of phosphate metabolic process (GO:0045937) 2.784FLT3, KIT, JAK2, KRAS
regulation of developmental process (GO:0050793) 2.14KIT, GATA2, RUNX1, TERT
protein complex assembly (GO:0006461) 2.784PICALM, TERT, JAK2, NPM1
phosphorylation (GO:0016310) 2.634FLT3, KIT, JAK2, KRAS
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091) 4.294KRAS, KIT, JAK2, NPM1
positive regulation of MAPK cascade (GO:0043410) 3.574FLT3, KIT, JAK2, KRAS
cell activation (GO:0001775) 3.474CBFB, KIT, GATA2, FLT3
multi-organism cellular process (GO:0044764) 3.144DDX41, CEBPA, NUP214, NPM1
locomotion (GO:0040011) 2.914GATA2, KIT, KRAS, JAK2
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.154DDX41, CEBPA, NUP214, NPM1
positive regulation of intracellular signal transduction (GO:1902533) 2.954KRAS, KIT, FLT3, JAK2
regulation of intracellular signal transduction (GO:1902531) 2.314KRAS, KIT, FLT3, JAK2
leukocyte differentiation (GO:0002521) 4.134CBFB, KIT, FLT3, CEBPA
regulation of hydrolase activity (GO:0051336) 2.534PICALM, KIT, NPM1, JAK2
establishment of protein localization (GO:0045184) 2.534TERT, JAK2, NUP214, NPM1
positive regulation of phosphorylation (GO:0042327) 2.94FLT3, KIT, JAK2, KRAS
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.834KIT, KRAS, JAK2, NPM1
regulation of cell cycle (GO:0051726) 2.934CEBPA, MLF1, NUP214, NPM1
positive regulation of protein modification process (GO:0031401) 2.74KRAS, KIT, FLT3, JAK2
chemical homeostasis (GO:0048878) 2.974PICALM, GATA2, CEBPA, JAK2
phosphate-containing compound metabolic process (GO:0006796) 2.164FLT3, KIT, JAK2, KRAS
viral process (GO:0016032) 3.154DDX41, CEBPA, NUP214, NPM1
phosphorus metabolic process (GO:0006793) 2.154FLT3, KIT, JAK2, KRAS
single-organism intracellular transport (GO:1902582) 3.594GATA2, KIT, JAK2, NUP214
single-organism cellular localization (GO:1902580) 3.164GATA2, KIT, JAK2, NUP214
positive regulation of protein phosphorylation (GO:0001934) 2.954KRAS, KIT, FLT3, JAK2
nuclear transport (GO:0051169) 4.23JAK2, NPM1, NUP214
protein localization (GO:0008104) 2.363JAK2, NPM1, NUP214
regulation of binding (GO:0051098) 4.083JAK2, TERT, NSD1
regulation of organelle organization (GO:0033043) 2.723GATA2, NPM1, NSD1
embryonic organ development (GO:0048568) 4.863GATA2, KIT, CEBPA
positive regulation of JAK-STAT cascade (GO:0046427) 5.443KIT, FLT3, JAK2
metal ion homeostasis (GO:0055065) 3.613GATA2, PICALM, JAK2
cell maturation (GO:0048469) 4.983CBFB, GATA2, CEBPA
peptidyl-tyrosine phosphorylation (GO:0018108) 4.483KIT, FLT3, JAK2
positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531) 5.633KIT, FLT3, JAK2
positive regulation of MAP kinase activity (GO:0043406) 4.393KIT, FLT3, KRAS
regulation of vasculature development (GO:1901342) 4.263KIT, GATA2, RUNX1
cell cycle process (GO:0022402) 2.753NUP214, MLF1, NPM1
lymphocyte differentiation (GO:0030098) 4.493CBFB, KIT, FLT3
cellular macromolecular complex assembly (GO:0034622) 3.183PICALM, NPM1, JAK2
inorganic ion homeostasis (GO:0098771) 3.433GATA2, PICALM, JAK2
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.063KIT, KRAS, FLT3
cell death (GO:0008219) 3.053DDX41, KIT, JAK2
programmed cell death (GO:0012501) 3.13DDX41, KIT, JAK2
multicellular organism development (GO:0007275) 2.543DDX41, CEBPA, MLF1
signal transduction by protein phosphorylation (GO:0023014) 3.793KIT, JAK2, KRAS
regulation of protein localization (GO:0032880) 2.883PICALM, JAK2, TERT
response to endogenous stimulus (GO:0009719) 2.793KIT, KRAS, FLT3
negative regulation of protein metabolic process (GO:0051248) 2.823PICALM, NPM1, CEBPA
positive regulation of vasculature development (GO:1904018) 4.833KIT, GATA2, RUNX1
negative regulation of cell cycle (GO:0045786) 3.673CEBPA, MLF1, NPM1
positive regulation of hydrolase activity (GO:0051345) 2.913PICALM, KIT, JAK2
regulation of cytokine production (GO:0001817) 3.43DDX41, RUNX1, JAK2
intracellular protein transport (GO:0006886) 3.23JAK2, NUP214, NPM1
negative regulation of multicellular organismal process (GO:0051241) 2.843GATA2, RUNX1, JAK2
MAPK cascade (GO:0000165) 3.913KIT, JAK2, KRAS
hematopoietic progenitor cell differentiation (GO:0002244) 5.233KIT, FLT3, MLF1
protein autophosphorylation (GO:0046777) 4.463KIT, FLT3, JAK2
positive regulation of STAT cascade (GO:1904894) 5.443KIT, FLT3, JAK2
positive regulation of immune system process (GO:0002684) 2.963GATA2, RUNX1, KRAS
response to organic cyclic compound (GO:0014070) 3.073KRAS, FLT3, CEBPA
histone modification (GO:0016570) 3.913WHSC1L1, JAK2, NSD1
organic substance transport (GO:0071702) 2.153JAK2, NPM1, NUP214
anatomical structure homeostasis (GO:0060249) 4.253GATA2, KRAS, TERT
myeloid progenitor cell differentiation (GO:0002318) 7.783KIT, FLT3, MLF1
macromolecule localization (GO:0033036) 2.343JAK2, NUP214, NPM1
regulation of anatomical structure morphogenesis (GO:0022603) 2.793KIT, GATA2, RUNX1
ion homeostasis (GO:0050801) 3.423GATA2, PICALM, JAK2
negative regulation of developmental process (GO:0051093) 3.173GATA2, RUNX1, TERT
response to cytokine (GO:0034097) 3.843DDX41, FLT3, JAK2
regulation of JAK-STAT cascade (GO:0046425) 4.783KIT, FLT3, JAK2
establishment of protein localization to organelle (GO:0072594) 3.923JAK2, TERT, NUP214
negative regulation of cell differentiation (GO:0045596) 3.333GATA2, RUNX1, KRAS
nucleocytoplasmic transport (GO:0006913) 4.233JAK2, NUP214, NPM1
defense response (GO:0006952) 2.783DDX41, KIT, JAK2
reproductive process (GO:0022414) 2.553GATA2, KIT, CEBPA
immune effector process (GO:0002252) 3.583DDX41, KIT, GATA2
regulation of immune response (GO:0050776) 2.983KIT, KRAS, JAK2
regulation of proteolysis (GO:0030162) 3.23PICALM, JAK2, CEBPA
positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068) 5.593KIT, FLT3, JAK2
regulation of STAT cascade (GO:1904892) 4.783KIT, FLT3, JAK2
cation homeostasis (GO:0055080) 3.463GATA2, PICALM, JAK2
regulation of neuron death (GO:1901214) 4.193PICALM, KRAS, JAK2
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066) 4.793KIT, FLT3, JAK2
regulation of tyrosine phosphorylation of STAT protein (GO:0042509) 5.493KIT, FLT3, JAK2
response to abiotic stimulus (GO:0009628) 2.83KIT, TERT, KRAS
negative regulation of cellular protein metabolic process (GO:0032269) 2.883PICALM, NPM1, CEBPA
single organism reproductive process (GO:0044702) 2.733GATA2, KIT, CEBPA
endocytosis (GO:0006897) 3.693PICALM, SH3GL1, GATA2
homeostasis of number of cells (GO:0048872) 4.983GATA2, KRAS, FLT3
response to external stimulus (GO:0009605) 2.553DDX41, KIT, JAK2
positive regulation of developmental process (GO:0051094) 2.773KIT, GATA2, RUNX1
peptidyl-lysine modification (GO:0018205) 3.983WHSC1L1, NUP214, NSD1
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.353KIT, FLT3, JAK2
regulation of cellular response to stress (GO:0080135) 3.43TERT, NUP214, NPM1
negative regulation of catalytic activity (GO:0043086) 3.03PICALM, NPM1, CEBPA
peptidyl-tyrosine modification (GO:0018212) 4.473KIT, FLT3, JAK2
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 4.623KIT, FLT3, JAK2
single-organism organelle organization (GO:1902589) 2.683PICALM, KIT, KRAS
lymphocyte activation (GO:0046649) 3.963CBFB, KIT, FLT3
regulation of multicellular organismal development (GO:2000026) 2.313KIT, GATA2, RUNX1
cellular response to stress (GO:0033554) 2.513JAK2, TERT, NPM1
response to hormone (GO:0009725) 3.333KIT, KRAS, FLT3
protein transport (GO:0015031) 2.623JAK2, NUP214, NPM1
positive regulation of proteolysis (GO:0045862) 3.863PICALM, JAK2, CEBPA
positive regulation of cytokine production (GO:0001819) 3.823DDX41, RUNX1, JAK2
developmental process involved in reproduction (GO:0003006) 3.363GATA2, KIT, CEBPA
chromatin modification (GO:0016568) 4.063WHSC1L1, JAK2, NSD1
covalent chromatin modification (GO:0016569) 3.893WHSC1L1, JAK2, NSD1
protein methylation (GO:0006479) 4.962WHSC1L1, NSD1
regulation of chromosome organization (GO:0033044) 4.112GATA2, NSD1
negative regulation of transferase activity (GO:0051348) 3.872NPM1, CEBPA
hemostasis (GO:0007599) 4.52GATA2, JAK2
regulation of apoptotic signaling pathway (GO:2001233) 3.832JAK2, TERT
negative regulation of response to stimulus (GO:0048585) 2.522GATA2, TERT
blood coagulation (GO:0007596) 4.522GATA2, JAK2
learning (GO:0007612) 4.852KIT, KRAS
activation of protein kinase activity (GO:0032147) 4.082KIT, JAK2
behavior (GO:0007610) 3.472KIT, KRAS
learning or memory (GO:0007611) 4.332KIT, KRAS
positive regulation of defense response (GO:0031349) 3.832KRAS, JAK2
ossification (GO:0001503) 4.862CBFB, RUNX1
negative regulation of neuron apoptotic process (GO:0043524) 4.822KRAS, JAK2
calcium ion homeostasis (GO:0055074) 3.972GATA2, JAK2
regulation of histone modification (GO:0031056) 4.852GATA2, NSD1
negative regulation of myeloid cell differentiation (GO:0045638) 5.422GATA2, RUNX1
establishment of organelle localization (GO:0051656) 4.152GATA2, KIT
tissue homeostasis (GO:0001894) 4.782GATA2, KRAS
mitochondrion organization (GO:0007005) 3.692TERT, CEBPA
response to external biotic stimulus (GO:0043207) 3.132DDX41, JAK2
cellular macromolecule localization (GO:0070727) 3.12JAK2, NUP214
posttranscriptional regulation of gene expression (GO:0010608) 3.642NPM1, NUP214
cell activation involved in immune response (GO:0002263) 4.862GATA2, KIT
protein modification by small protein conjugation or removal (GO:0070647) 2.952CBFB, NUP214
protein modification by small protein conjugation (GO:0032446) 3.12CBFB, NUP214
positive regulation of lipid metabolic process (GO:0045834) 4.882KIT, FLT3
B cell differentiation (GO:0030183) 5.242KIT, FLT3
negative regulation of immune system process (GO:0002683) 3.852GATA2, RUNX1
cellular homeostasis (GO:0019725) 3.232GATA2, JAK2
positive regulation of transport (GO:0051050) 2.92GATA2, JAK2
erythrocyte differentiation (GO:0030218) 5.882KIT, JAK2
response to corticosteroid (GO:0031960) 4.562KRAS, FLT3
protein import into nucleus (GO:0006606) 5.242JAK2, NUP214
positive regulation of hemopoiesis (GO:1903708) 4.632GATA2, RUNX1
regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522) 6.682KIT, JAK2
lymphoid progenitor cell differentiation (GO:0002320) 7.332KIT, FLT3
response to biotic stimulus (GO:0009607) 3.092DDX41, JAK2
regulation of hemopoiesis (GO:1903706) 4.02GATA2, RUNX1
negative regulation of hemopoiesis (GO:1903707) 4.962GATA2, RUNX1
system process (GO:0003008) 2.32KIT, KRAS
positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523) 6.92KIT, JAK2
stem cell population maintenance (GO:0019827) 4.832GATA2, KIT
negative regulation of phosphorylation (GO:0042326) 3.72NPM1, CEBPA
organonitrogen compound metabolic process (GO:1901564) 2.322KIT, CEBPA
mast cell activation involved in immune response (GO:0002279) 7.092GATA2, KIT
single-organism behavior (GO:0044708) 3.792KIT, KRAS
myeloid cell activation involved in immune response (GO:0002275) 6.072GATA2, KIT
myeloid leukocyte activation (GO:0002274) 5.152GATA2, KIT
positive regulation of cytosolic calcium ion concentration (GO:0007204) 4.562GATA2, JAK2
positive regulation of oxidoreductase activity (GO:0051353) 5.942KRAS, TERT
regulation of vesicle-mediated transport (GO:0060627) 3.632GATA2, PICALM
regulation of neuron apoptotic process (GO:0043523) 4.472KRAS, JAK2
positive regulation of nitric-oxide synthase activity (GO:0051000) 6.782KRAS, TERT
negative regulation of kinase activity (GO:0033673) 4.222NPM1, CEBPA
visual behavior (GO:0007632) 5.822KIT, KRAS
digestive tract development (GO:0048565) 5.492GATA2, KIT
peptidyl-lysine methylation (GO:0018022) 5.422WHSC1L1, NSD1
lysosome localization (GO:0032418) 6.682GATA2, KIT
regulation of synaptic plasticity (GO:0048167) 4.782KIT, KRAS
regulation of cell migration (GO:0030334) 3.232KIT, JAK2
regulation of long-term neuronal synaptic plasticity (GO:0048169) 6.552KIT, KRAS
regulation of neuronal synaptic plasticity (GO:0048168) 5.842KIT, KRAS
regulation of myeloid leukocyte differentiation (GO:0002761) 5.022GATA2, RUNX1
regulation of oxidoreductase activity (GO:0051341) 5.272KRAS, TERT
negative regulation of myeloid leukocyte differentiation (GO:0002762) 5.92GATA2, RUNX1
immune response-regulating signaling pathway (GO:0002764) 3.722KIT, KRAS
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962KIT, KRAS
exocytosis (GO:0006887) 4.112GATA2, KIT
regulated exocytosis (GO:0045055) 4.442GATA2, KIT
leukocyte activation involved in immune response (GO:0002366) 4.882GATA2, KIT
histone methylation (GO:0016571) 5.32WHSC1L1, NSD1
regulation of defense response (GO:0031347) 3.112KRAS, JAK2
methylation (GO:0032259) 4.062WHSC1L1, NSD1
positive regulation of cellular component organization (GO:0051130) 2.682GATA2, KIT
cellular protein localization (GO:0034613) 3.112JAK2, NUP214
lipid metabolic process (GO:0006629) 2.682KIT, CEBPA
positive regulation of lipid kinase activity (GO:0090218) 6.232KIT, FLT3
positive regulation of protein localization to nucleus (GO:1900182) 4.872JAK2, TERT
regulation of monooxygenase activity (GO:0032768) 5.692KRAS, TERT
tissue development (GO:0009888) 3.272GATA2, JAK2
maintenance of cell number (GO:0098727) 4.822GATA2, KIT
associative learning (GO:0008306) 5.442KIT, KRAS
macromolecule methylation (GO:0043414) 4.422WHSC1L1, NSD1
somatic stem cell population maintenance (GO:0035019) 5.522GATA2, KIT
regulation of phospholipid metabolic process (GO:1903725) 5.692KIT, FLT3
negative regulation of neuron death (GO:1901215) 4.572KRAS, JAK2
gland development (GO:0048732) 4.152GATA2, CEBPA
regulation of phosphatidylinositol 3-kinase activity (GO:0043551) 6.022KIT, FLT3
regulation of protein localization to nucleus (GO:1900180) 4.342JAK2, TERT
secretion (GO:0046903) 3.382GATA2, KIT
positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552) 6.292KIT, FLT3
negative regulation of signal transduction (GO:0009968) 2.752GATA2, TERT
coagulation (GO:0050817) 4.512GATA2, JAK2
cellular response to cytokine stimulus (GO:0071345) 4.332DDX41, FLT3
negative regulation of protein modification process (GO:0031400) 3.42NPM1, CEBPA
regulation of protein stability (GO:0031647) 4.332KRAS, TERT
cognition (GO:0050890) 4.22KIT, KRAS
positive regulation of nervous system development (GO:0051962) 3.642GATA2, KIT
protein localization to nucleus (GO:0034504) 4.92JAK2, NUP214
regulation of nervous system development (GO:0051960) 3.12GATA2, KIT
regulation of cell motility (GO:2000145) 3.162KIT, JAK2
positive regulation of cell motility (GO:2000147) 3.742KIT, JAK2
regulation of myeloid cell differentiation (GO:0045637) 4.562GATA2, RUNX1
positive regulation of cellular amide metabolic process (GO:0034250) 5.02PICALM, NPM1
positive regulation of monooxygenase activity (GO:0032770) 6.472KRAS, TERT
regulation of synapse structure or activity (GO:0050803) 4.772KIT, KRAS
response to radiation (GO:0009314) 3.692KIT, KRAS
negative regulation of cellular component organization (GO:0051129) 3.352PICALM, NPM1
modulation of synaptic transmission (GO:0050804) 4.092KIT, KRAS
regulation of cellular protein localization (GO:1903827) 3.432JAK2, TERT
negative regulation of signaling (GO:0023057) 2.652GATA2, TERT
response to light stimulus (GO:0009416) 4.082KIT, KRAS
negative regulation of cell communication (GO:0010648) 2.662GATA2, TERT
anatomical structure morphogenesis (GO:0009653) 2.532GATA2, KRAS
regulation of GTPase activity (GO:0043087) 3.212KIT, JAK2
visual learning (GO:0008542) 5.922KIT, KRAS
positive regulation of cellular protein localization (GO:1903829) 3.852JAK2, TERT
regulation of neurogenesis (GO:0050767) 3.212GATA2, KIT
positive regulation of phospholipid metabolic process (GO:1903727) 5.992KIT, FLT3
cellular divalent inorganic cation homeostasis (GO:0072503) 3.962GATA2, JAK2
cellular protein complex assembly (GO:0043623) 3.92PICALM, JAK2
negative regulation of phosphorus metabolic process (GO:0010563) 3.452NPM1, CEBPA
regeneration (GO:0031099) 4.72FLT3, JAK2
regulation of cell development (GO:0060284) 3.012GATA2, KIT
positive regulation of neurogenesis (GO:0050769) 3.772GATA2, KIT
homeostasis of number of cells within a tissue (GO:0048873) 6.332GATA2, KRAS
histone lysine methylation (GO:0034968) 5.572WHSC1L1, NSD1
biological adhesion (GO:0022610) 2.812LPP, KIT
cellular response to endogenous stimulus (GO:0071495) 3.332KIT, FLT3
positive regulation of cell development (GO:0010720) 3.572GATA2, KIT
regulation of body fluid levels (GO:0050878) 3.762GATA2, JAK2
single-organism nuclear import (GO:1902593) 5.242JAK2, NUP214
cellular metal ion homeostasis (GO:0006875) 3.752GATA2, JAK2
cellular calcium ion homeostasis (GO:0006874) 4.012GATA2, JAK2
protein import (GO:0017038) 4.852JAK2, NUP214
cellular ion homeostasis (GO:0006873) 3.572GATA2, JAK2
regulation of cellular amide metabolic process (GO:0034248) 3.882PICALM, NPM1
regulation of DNA binding (GO:0051101) 5.212JAK2, NSD1
regulation of locomotion (GO:0040012) 3.122KIT, JAK2
mitotic cell cycle process (GO:1903047) 3.122NPM1, NUP214
cellular cation homeostasis (GO:0030003) 3.62GATA2, JAK2
definitive hemopoiesis (GO:0060216) 6.962CBFB, GATA2
cellular chemical homeostasis (GO:0055082) 3.42GATA2, JAK2
embryonic placenta development (GO:0001892) 6.592GATA2, CEBPA
regulation of fat cell differentiation (GO:0045598) 5.042GATA2, CEBPA
positive regulation of NF-kappaB transcription factor activity (GO:0051092) 4.852KRAS, NPM1
aging (GO:0007568) 4.162NPM1, TERT
cell aging (GO:0007569) 5.542NPM1, TERT
cellular response to organic cyclic compound (GO:0071407) 3.932FLT3, CEBPA
positive regulation of binding (GO:0051099) 4.882JAK2, TERT
secretion by cell (GO:0032940) 3.592GATA2, KIT
protein localization to organelle (GO:0033365) 3.572JAK2, NUP214
system development (GO:0048731) 2.922GATA2, SH3GL1
stem cell proliferation (GO:0072089) 6.072RUNX1, ETV6
response to steroid hormone (GO:0048545) 4.242KRAS, FLT3
regulation of chromatin organization (GO:1902275) 4.692GATA2, NSD1
response to glucocorticoid (GO:0051384) 4.632KRAS, FLT3
regulation of cellular localization (GO:0060341) 3.032JAK2, TERT
cell projection organization (GO:0030030) 3.142KIT, JAK2
B cell activation (GO:0042113) 4.842KIT, FLT3
actin cytoskeleton organization (GO:0030036) 4.12KIT, KRAS
protein alkylation (GO:0008213) 4.962WHSC1L1, NSD1
leukocyte migration (GO:0050900) 4.192KIT, KRAS
Fc receptor signaling pathway (GO:0038093) 4.452KIT, KRAS
positive regulation of cell death (GO:0010942) 3.322PICALM, JAK2
regulation of lipid kinase activity (GO:0043550) 5.842KIT, FLT3
divalent inorganic cation homeostasis (GO:0072507) 3.92GATA2, JAK2
mast cell degranulation (GO:0043303) 7.092GATA2, KIT
regulation of cellular component biogenesis (GO:0044087) 3.082KIT, NPM1
regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516) 5.942KIT, JAK2
positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517) 6.122KIT, JAK2
positive regulation of angiogenesis (GO:0045766) 4.932GATA2, RUNX1
myeloid leukocyte differentiation (GO:0002573) 5.232KIT, CEBPA
leukocyte proliferation (GO:0070661) 5.252KIT, FLT3
positive regulation of myeloid cell differentiation (GO:0045639) 5.332GATA2, RUNX1
negative regulation of phosphate metabolic process (GO:0045936) 3.452NPM1, CEBPA
neurological system process (GO:0050877) 2.642KIT, KRAS
regulation of angiogenesis (GO:0045765) 4.362GATA2, RUNX1
neuron development (GO:0048666) 4.82GATA2, RUNX1
positive regulation of cell migration (GO:0030335) 3.772KIT, JAK2
negative regulation of protein kinase activity (GO:0006469) 4.292NPM1, CEBPA
regulation of innate immune response (GO:0045088) 3.862KRAS, JAK2
actin filament-based process (GO:0030029) 3.942KIT, KRAS
regulation of lipid metabolic process (GO:0019216) 4.082KIT, FLT3
regulation of endopeptidase activity (GO:0052548) 3.82PICALM, JAK2
apoptotic process (GO:0006915) 3.142DDX41, JAK2
nuclear import (GO:0051170) 5.062JAK2, NUP214
regulation of Notch signaling pathway (GO:0008593) 5.512GATA2, KIT
cell adhesion (GO:0007155) 2.822LPP, KIT
tube development (GO:0035295) 4.412GATA2, KIT
positive regulation of peptidase activity (GO:0010952) 4.72PICALM, JAK2
regulation of endocytosis (GO:0030100) 4.422GATA2, PICALM
organelle localization (GO:0051640) 3.942GATA2, KIT
positive regulation of GTPase activity (GO:0043547) 3.282KIT, JAK2
regulation of nitric-oxide synthase activity (GO:0050999) 5.92KRAS, TERT
positive regulation of cellular component movement (GO:0051272) 3.712KIT, JAK2
regulation of cellular component movement (GO:0051270) 3.082KIT, JAK2
cytoskeleton organization (GO:0007010) 3.222KIT, KRAS
hematopoietic stem cell proliferation (GO:0071425) 7.162RUNX1, ETV6
positive regulation of locomotion (GO:0040017) 3.712KIT, JAK2
regulation of cytosolic calcium ion concentration (GO:0051480) 4.412GATA2, JAK2
cellular response to hormone stimulus (GO:0032870) 3.992KIT, FLT3
negative regulation of leukocyte differentiation (GO:1902106) 5.32GATA2, RUNX1
regulation of leukocyte differentiation (GO:1902105) 4.262GATA2, RUNX1
leukocyte degranulation (GO:0043299) 6.42GATA2, KIT
regulation of peptidase activity (GO:0052547) 3.752PICALM, JAK2
DNA metabolic process (GO:0006259) 3.092NPM1, TERT
negative regulation of protein phosphorylation (GO:0001933) 3.792NPM1, CEBPA
RNA processing (GO:0006396) 3.012DDX41, TERT
mast cell activation (GO:0045576) 6.732GATA2, KIT

NET-GE enrichment

Term New enriched termICP valueGenes
response to erythropoietin (GO:0036017) NEW8.630.044KIT, JAK2
cytokine-mediated signaling pathway (GO:0019221) -3.60.007KIT, CEBPA, NUP214, KRAS, JAK2, FLT3
positive regulation of cellular biosynthetic process (GO:0031328) -2.30.0CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, RUNX1, GATA2, NSD1
regulation of cellular biosynthetic process (GO:0031326) -1.380.036CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, RUNX1, GATA2, WHSC1L1
positive regulation of cellular metabolic process (GO:0031325) -1.810.0CBFB, KRAS, KIT, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, FLT3, NPM1, RUNX1, DDX41, NSD1
positive regulation of nitrogen compound metabolic process (GO:0051173) -2.290.002CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, JAK2, RUNX1, GATA2, NSD1
cell maturation (GO:0048469) -4.980.017CBFB, CEBPA, GATA2, KRAS, JAK2, RUNX1
negative regulation of gene expression (GO:0010629) -2.480.023PICALM, KRAS, CEBPA, NUP214, NSD1, GATA2, FLT3, ETV6, JAK2, TERT, NPM1, RUNX1, WHSC1L1
positive regulation of gene expression (GO:0010628) -2.350.0CBFB, KIT, CEBPA, DDX41, PICALM, ETV6, MLLT10, KRAS, RUNX1, GATA2, NSD1
negative regulation of myeloid cell differentiation (GO:0045638) -5.420.014GATA2, FLT3, RUNX1, JAK2, NSD1
regulation of protein serine/threonine kinase activity (GO:0071900) -3.580.03KRAS, KIT, FLT3, GATA2, JAK2, ETV6, TERT, NPM1, RUNX1
developmental maturation (GO:0021700) -4.70.032CBFB, CEBPA, GATA2, PICALM, JAK2, KRAS, RUNX1
positive regulation of metabolic process (GO:0009893) -1.740.0CBFB, KRAS, KIT, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, FLT3, NPM1, RUNX1, DDX41, NSD1
positive regulation of RNA biosynthetic process (GO:1902680) -2.540.006CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, RUNX1, GATA2, NSD1
positive regulation of macromolecule metabolic process (GO:0010604) -1.810.0CBFB, KRAS, KIT, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, FLT3, NPM1, RUNX1, DDX41, NSD1
cellular macromolecule metabolic process (GO:0044260) -0.930.013CBFB, WHSC1L1, NUP214, CEBPA, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, KIT, RUNX1, TGM6, GATA2
cellular developmental process (GO:0048869) -1.820.028CBFB, KRAS, KIT, CEBPA, GATA2, PICALM, ETV6, JAK2, MLF1, FLT3, RUNX1
positive regulation of biosynthetic process (GO:0009891) -2.290.0CBFB, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, NSD1
regulation of cellular macromolecule biosynthetic process (GO:2000112) -1.460.016CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531) -5.630.013KIT, RUNX1, FLT3, JAK2
myeloid leukocyte differentiation (GO:0002573) -5.230.01KIT, GATA2, RUNX1, CEBPA, JAK2
hematopoietic progenitor cell differentiation (GO:0002244) -5.230.004KIT, FLT3, JAK2, MLF1, TERT, RUNX1
positive regulation of myeloid cell differentiation (GO:0045639) -5.330.009KIT, GATA2, RUNX1, KRAS, JAK2
positive regulation of transcription, DNA-templated (GO:0045893) -2.560.004CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, RUNX1, GATA2, NSD1
embryonic organ development (GO:0048568) -4.860.015KIT, CEBPA, GATA2, JAK2, FLT3, RUNX1
lymphoid progenitor cell differentiation (GO:0002320) -7.330.008KIT, FLT3, JAK2
hematopoietic or lymphoid organ development (GO:0048534) -4.490.0CBFB, KRAS, KIT, GATA2, PICALM, JAK2, NPM1, FLT3, RUNX1
regulation of gene expression (GO:0010468) -1.370.049CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, WHSC1L1
developmental process (GO:0032502) -1.360.003CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, PICALM, ETV6, JAK2, MLF1, TERT, NPM1, SH3GL1, RUNX1, GATA2, NSD1
cell differentiation (GO:0030154) -2.140.008CBFB, KRAS, KIT, CEBPA, GATA2, ETV6, JAK2, MLF1, FLT3, RUNX1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) -2.350.017CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, RUNX1, GATA2, NSD1
response to cytokine (GO:0034097) -3.840.007KIT, CEBPA, NUP214, DDX41, JAK2, KRAS, FLT3
regulation of biosynthetic process (GO:0009889) -1.370.04CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, WHSC1L1
single-organism developmental process (GO:0044767) -1.490.006CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, PICALM, ETV6, JAK2, MLF1, TERT, NPM1, RUNX1, DDX41, NSD1
regulation of osteoblast differentiation (GO:0045667) NEW4.990.003CEBPA, GATA2, JAK2, LPP, NPM1, RUNX1
lymphocyte activation (GO:0046649) -3.960.039CBFB, KRAS, KIT, GATA2, JAK2, NPM1, FLT3, RUNX1
positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068) -5.590.032KIT, FLT3, JAK2
definitive hemopoiesis (GO:0060216) -6.960.001CBFB, RUNX1, GATA2
myeloid progenitor cell differentiation (GO:0002318) -7.780.0KIT, RUNX1, FLT3, MLF1
leukocyte differentiation (GO:0002521) -4.130.007CBFB, KIT, CEBPA, GATA2, JAK2, KRAS, FLT3, RUNX1
regulation of tyrosine phosphorylation of STAT protein (GO:0042509) -5.490.029KIT, RUNX1, FLT3, JAK2
regulation of RNA biosynthetic process (GO:2001141) -1.550.007CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, RUNX1, GATA2, WHSC1L1
negative regulation of phosphorylation (GO:0042326) -3.70.035KRAS, KIT, FLT3, GATA2, JAK2, NPM1, TERT, RUNX1
cellular response to erythropoietin (GO:0036018) NEW8.630.044KIT, JAK2
cellular response to cytokine stimulus (GO:0071345) -4.330.002KIT, CEBPA, NUP214, DDX41, JAK2, KRAS, FLT3
positive regulation of JAK-STAT cascade (GO:0046427) -5.440.042KIT, RUNX1, FLT3, JAK2
regulation of RNA metabolic process (GO:0051252) -1.520.009CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, RUNX1, GATA2, WHSC1L1
positive regulation of RNA metabolic process (GO:0051254) -2.510.006CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, RUNX1, GATA2, NSD1
cytokine production (GO:0001816) NEW5.420.006KIT, GATA2, RUNX1, KRAS, JAK2
regulation of transcription, DNA-templated (GO:0006355) -1.560.006CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of macromolecule biosynthetic process (GO:0010557) -2.390.0CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, RUNX1, GATA2, NSD1
regulation of macromolecule biosynthetic process (GO:0010556) -1.430.023CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) -2.810.049CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, FLT3, RUNX1, GATA2, NSD1
lymphocyte differentiation (GO:0030098) -4.490.008CBFB, KIT, GATA2, JAK2, KRAS, FLT3, RUNX1
myeloid cell differentiation (GO:0030099) -4.630.001CBFB, KIT, CEBPA, GATA2, JAK2, ETV6, RUNX1
hemopoiesis (GO:0030097) -5.070.0CBFB, KIT, GATA2, PICALM, JAK2, FLT3, RUNX1
regulation of myeloid cell differentiation (GO:0045637) -4.560.005KIT, GATA2, JAK2, KRAS, FLT3, RUNX1, NSD1
positive regulation of cellular process (GO:0048522) -1.30.017CBFB, KRAS, KIT, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, FLT3, RUNX1, GATA2, NSD1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.2823CHIC2, NUP214, GATA2, CBFB, JAK2, LPP, MLF1, RUNX1, CEBPA, TGM6, KRAS, MLLT10, KIT, FLT3, DDX41, NPM1, SETBP1, WHSC1L1, PICALM, ETV6, TERT, SH3GL1, NSD1
cell part (GO:0044464) 0.1123CBFB, NUP214, GATA2, CHIC2, JAK2, LPP, NPM1, RUNX1, CEBPA, TGM6, KRAS, MLLT10, KIT, FLT3, DDX41, SETBP1, WHSC1L1, PICALM, MLF1, ETV6, TERT, SH3GL1, NSD1
intracellular organelle (GO:0043229) 0.5122CBFB, NUP214, GATA2, CHIC2, JAK2, LPP, NPM1, RUNX1, CEBPA, KRAS, MLLT10, KIT, FLT3, DDX41, SETBP1, WHSC1L1, PICALM, MLF1, ETV6, TERT, SH3GL1, NSD1
membrane-bounded organelle (GO:0043227) 0.4722CBFB, NUP214, GATA2, CHIC2, JAK2, LPP, NPM1, RUNX1, CEBPA, KRAS, MLLT10, KIT, FLT3, DDX41, SETBP1, WHSC1L1, PICALM, MLF1, ETV6, TERT, SH3GL1, NSD1
intracellular membrane-bounded organelle (GO:0043231) 0.622CHIC2, NUP214, GATA2, CBFB, JAK2, LPP, MLF1, RUNX1, CEBPA, KRAS, MLLT10, KIT, FLT3, DDX41, NPM1, SETBP1, WHSC1L1, PICALM, ETV6, TERT, SH3GL1, NSD1
organelle (GO:0043226) 0.422CBFB, NUP214, GATA2, CHIC2, JAK2, LPP, NPM1, RUNX1, CEBPA, KRAS, MLLT10, KIT, FLT3, DDX41, SETBP1, WHSC1L1, PICALM, MLF1, ETV6, TERT, SH3GL1, NSD1
nucleus (GO:0005634) 1.0718CBFB, NUP214, CEBPA, NSD1, DDX41, FLT3, ETV6, LPP, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, SETBP1, RUNX1, GATA2, WHSC1L1
intracellular organelle part (GO:0044446) 0.8116CHIC2, NUP214, CEBPA, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, NPM1, TERT, PICALM, SH3GL1, RUNX1, GATA2, WHSC1L1
organelle part (GO:0044422) 0.7916CHIC2, NUP214, CEBPA, NSD1, GATA2, FLT3, ETV6, MLLT10, JAK2, TERT, NPM1, PICALM, SH3GL1, RUNX1, DDX41, WHSC1L1
cytoplasm (GO:0005737) 1.0113KRAS, KIT, FLT3, TGM6, ETV6, LPP, JAK2, MLLT10, MLF1, TERT, NPM1, SH3GL1, RUNX1
cytoplasmic part (GO:0044444) 0.8212CHIC2, KRAS, KIT, FLT3, NUP214, DDX41, PICALM, JAK2, NPM1, TERT, SH3GL1, GATA2
membrane (GO:0016020) 0.6812CHIC2, KRAS, KIT, DDX41, CBFB, ETV6, LPP, JAK2, FLT3, NPM1, PICALM, SH3GL1
nuclear part (GO:0044428) 1.5512WHSC1L1, NUP214, CEBPA, DDX41, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
nucleoplasm (GO:0005654) 1.899NUP214, GATA2, JAK2, MLLT10, NSD1, TERT, NPM1, RUNX1, WHSC1L1
macromolecular complex (GO:0032991) 1.359PICALM, CEBPA, NUP214, DDX41, FLT3, NPM1, TERT, SH3GL1, GATA2
non-membrane-bounded organelle (GO:0043228) 1.768CEBPA, JAK2, ETV6, WHSC1L1, TERT, NPM1, SH3GL1, NSD1
intracellular non-membrane-bounded organelle (GO:0043232) 1.768CEBPA, JAK2, ETV6, WHSC1L1, TERT, NPM1, SH3GL1, NSD1
protein complex (GO:0043234) 1.517PICALM, TERT, NUP214, GATA2, FLT3, SH3GL1, CEBPA
membrane part (GO:0044425) 0.957PICALM, KRAS, KIT, JAK2, ETV6, FLT3, RUNX1
cytosol (GO:0005829) 1.687KRAS, NUP214, GATA2, JAK2, NPM1, FLT3, DDX41
cell junction (GO:0030054) 2.756KIT, NUP214, KRAS, LPP, NPM1, SH3GL1
plasma membrane part (GO:0044459) 1.955PICALM, KRAS, KIT, FLT3, JAK2
plasma membrane (GO:0005886) 1.395LPP, CHIC2, KIT, FLT3, KRAS
nucleolus (GO:0005730) 3.064ETV6, TERT, CEBPA, NPM1
integral component of membrane (GO:0016021) 1.144KIT, RUNX1, FLT3, ETV6
anchoring junction (GO:0070161) 3.614LPP, KRAS, NPM1, NUP214
adherens junction (GO:0005912) 3.664LPP, KRAS, NPM1, NUP214
cell-substrate adherens junction (GO:0005924) 3.834LPP, KRAS, NPM1, NUP214
focal adhesion (GO:0005925) 3.834LPP, KRAS, NUP214, NPM1
intrinsic component of membrane (GO:0031224) 1.134KIT, RUNX1, FLT3, ETV6
cell-substrate junction (GO:0030055) 3.824LPP, KRAS, NUP214, NPM1
vesicle (GO:0031982) 1.643CHIC2, KIT, PICALM
vacuole (GO:0005773) 2.923SH3GL1, KIT, GATA2
cytoplasmic vesicle (GO:0031410) 2.873CHIC2, KIT, PICALM
membrane region (GO:0098589) 3.953PICALM, KRAS, JAK2
ribonucleoprotein complex (GO:1990904) 3.193DDX41, NPM1, TERT
membrane-bounded vesicle (GO:0031988) 1.713CHIC2, KIT, PICALM
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.123CHIC2, KIT, PICALM
intracellular vesicle (GO:0097708) 2.863CHIC2, KIT, PICALM
intracellular ribonucleoprotein complex (GO:0030529) 3.193DDX41, NPM1, TERT
chromosome (GO:0005694) 3.783WHSC1L1, TERT, NSD1
cytoskeleton (GO:0005856) 2.552JAK2, NPM1
plasma membrane region (GO:0098590) 2.972PICALM, JAK2
endosomal part (GO:0044440) 3.732SH3GL1, JAK2
lytic vacuole (GO:0000323) 3.892GATA2, KIT
endoplasmic reticulum (GO:0005783) 2.562DDX41, FLT3
Golgi apparatus (GO:0005794) 2.72CHIC2, PICALM
organelle lumen (GO:0043233) 3.052FLT3, JAK2
mast cell granule (GO:0042629) 6.762GATA2, KIT
membrane-enclosed lumen (GO:0031974) 3.052FLT3, JAK2
extrinsic component of membrane (GO:0019898) 4.512KRAS, JAK2
lysosome (GO:0005764) 3.892GATA2, KIT
intracellular organelle lumen (GO:0070013) 3.052FLT3, JAK2
cytoskeletal part (GO:0044430) 2.492SH3GL1, NPM1
vacuolar part (GO:0044437) 3.262SH3GL1, JAK2
mitochondrion (GO:0005739) 2.422KRAS, TERT
transcription factor complex (GO:0005667) 4.12GATA2, CEBPA
membrane microdomain (GO:0098857) 4.172KRAS, JAK2
extrinsic component of cytoplasmic side of plasma membrane (GO:0031234) 5.632KRAS, JAK2
extrinsic component of plasma membrane (GO:0019897) 5.252KRAS, JAK2
membrane raft (GO:0045121) 4.182KRAS, JAK2

NET-GE enrichment

Term New enriched termICP valueGenes
external side of plasma membrane (GO:0009897) NEW4.460.021KIT, NUP214, KRAS, JAK2, FLT3, RUNX1
intracellular organelle (GO:0043229) -0.510.004SETBP1, CHIC2, KRAS, KIT, NUP214, CEBPA, DDX41, CBFB, ETV6, LPP, JAK2, MLLT10, WHSC1L1, MLF1, TERT, NPM1, PICALM, SH3GL1, RUNX1, GATA2, NSD1
nuclear part (GO:0044428) -1.550.014KRAS, KIT, NUP214, CEBPA, NSD1, DDX41, ETV6, LPP, JAK2, MLLT10, NPM1, TERT, SETBP1, RUNX1, GATA2, WHSC1L1
intracellular membrane-bounded organelle (GO:0043231) -0.60.025CHIC2, KRAS, KIT, NUP214, CEBPA, NSD1, DDX41, CBFB, ETV6, LPP, JAK2, MLLT10, MLF1, NPM1, PICALM, SETBP1, RUNX1, GATA2, WHSC1L1