Disease table of LEUKEMIA, ACUTE MYELOID OMIM ID: 601626

Gene-disease associations table

Gene	Associated with LEUKEMIA, ACUTE MYELOID in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TGM6	ClinVar	HGNC link	20p13	2	601626, PS164400
SETBP1	HUMSAVAR	HGNC link	18q12.3	6	601626, 614286, 608232, 269150, PS156200, 607785
SH3GL1	OMIM	HGNC link	19p13.3	1	601626
FLT3	ClinVar, OMIM	HGNC link	13q12.2	2	601626, 613065
CHIC2	OMIM	HGNC link	4q12	1	601626
CEBPA	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.11	1	601626
NPM1	ClinVar, OMIM	HGNC link	5q35.1	1	601626
WHSC1L1	OMIM	HGNC link	8p11.23	1	601626
CBFB	OMIM	HGNC link	16q22.1	1	601626
JAK2	ClinVar, OMIM, HUMSAVAR	HGNC link	9p24.1	5	263300, 601626, 254450, PS133100, PS187950
NUP214	OMIM	HGNC link	9q34.13	2	601626, 613065
TERT	ClinVar, OMIM	HGNC link	5p15.33	5	PS127550, 601626, 178500, PS155600, PS614742
MLF1	OMIM	HGNC link	3q25.32	1	601626
MLLT10	OMIM	HGNC link	10p12.31	1	601626
LPP	OMIM	HGNC link	3q27.3	1	601626
GATA2	OMIM	HGNC link	3q21.3	4	601626, 614286, 614038, 614172
KRAS	ClinVar, OMIM	HGNC link	12p12.1	14	601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350
ETV6	ClinVar, OMIM	HGNC link	12p13.2	2	601626, 616216
DDX41	ClinVar	HGNC link	5q35.3	2	601626, 616871
KIT	ClinVar, OMIM	HGNC link	4q12	5	601626, 172800, 273300, 606764, 154800
RUNX1	OMIM	HGNC link	21q22.12	2	601626, 601399
NSD1	OMIM	HGNC link	5q35.3	3	601626, 130650, PS117550
PICALM	OMIM	HGNC link	11q14.2	1	601626

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
4q12	2	CHIC2, KIT
5q35.3	2	DDX41, NSD1

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
4q12	2	CHIC2, KIT
5q35	3	NPM1, DDX41, NSD1

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
12p1	2	KRAS, ETV6
3q2	3	MLF1, GATA2, LPP
4q1	2	CHIC2, KIT
5q3	3	NPM1, DDX41, NSD1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
5q	3	NPM1, DDX41, NSD1
3q	3	MLF1, GATA2, LPP
4q	2	CHIC2, KIT
12p	2	KRAS, ETV6

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
12	2	KRAS, ETV6
19	2	CEBPA, SH3GL1
3	3	MLF1, GATA2, LPP
5	4	NPM1, TERT, NSD1, DDX41
4	2	CHIC2, KIT
9	2	JAK2, NUP214

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
SETBP1	YES	3	PTGS2, PTGER2, PPP2R4	0
CEBPA	YES	50	FN1, PRL, CXCR2, VLDLR, SLC2A4, TLR9, S100A9, CSF3R, MSR1, CSF1, AFP, ICAM1, SFTPD, ITGAX, INSR, HAMP, ELANE, STAR, SOCS3, DEFA1, CSF2RA, ID1, CYP3A4, SAA1, HOMER3, IGF1, GAPDH, PCK1, SLC10A1, CD163, SPP1, IL10, DEFA3, PCK2, F9, MAD1L1, SERPINC1, CDK2, BCL2, IL3, HSPA4, ALB, IGF2, IL5, IL6, HSD17B11, CRMP1, MYC, LEP, PRTN3	0
NPM1	YES	6	CDKN1A, PTPN6, TAF1A, ATF5, DNMT1, RPL3	0
CBFB	YES	1	GATA1	0
MLLT10	YES	3	CDKN1A, BAX, MDM2	0
GATA2	YES	16	WT1, PECAM1, CEBPA, DPYSL2, SPI1, PRG2, NOS3, CYBB, EPO, TSHB, GATA1, IL1RL1, ANGPT2, ERVW-1, PPARG, ADH1A	1	CEBPA
ETV6	YES	5	CDKN1A, BBC3, GAS2, MAD2L1, IGFBP5	0
RUNX1	YES	36	PF4, GP1BA, ITGA2B, MAD2L1, LGALS3, NCAM1, CCND2, BPI, SLC22A4, CSF1, MECOM, CCL3, BAALC, CSF2, SPI1, IL2, CD34, MYL9, ITGB2, CSF1R, TIMP1, VEGFA, MYH10, FHL2, MPO, KLK3, NF1, IL3, SYMPK, JUN, ELANE, PRKCQ, MPL, PIK3CD, KLF4, CD6	0
NSD1	YES	1	AR	0
PITX1	NO	13	IRF2, TERT, RUNX2, PRL, IFNA1, HES1, NKX3-1, IRF7, JUN, TBX4, TRIB2, LHB, RUNX1	2	RUNX1, TERT
STAT3	NO	129	IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP12	4	ETV6, FLT3, JAK2, TERT
MYC	NO	102	CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC1	4	CBFB, KRAS, TERT, CEBPA
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	3	CBFB, KIT, TERT
GATA1	NO	52	PF4, PBXIP1, CBFB, GP1BA, GP9, KLF1, FCER1A, ITGA2B, EPO, SEMG1, TBXA2R, BACE1, DACH1, PTGFR, GP6, HBA2, DPYSL2, GYPB, TAL1, CYBB, COPS5, DICER1, CDA, FURIN, GNAS, WT1, ZNF268, BDKRB1, SPI1, GP1BB, NFE2, F13A1, GFI1B, MPL, AGGF1, CCR3, GATA1, IFNG, HEMGN, HBE1, BACH1, PPOX, CEBPA, CDC6, HBB, PRG2, FLI1, EPOR, IL1RL1, SMAD1, HBG1, HBA1	2	CBFB, CEBPA

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
FLT3	YES	2	PML, STAT3	0
CEBPA	YES	8	LEF1, PPARA, GATA2, DDIT3, MYB, GATA1, MYC, PPARG	1	GATA2
CBFB	YES	3	SP1, MYC, GATA1	0
JAK2	YES	3	BRCA1, STAT3, STAT1	0
TERT	YES	30	CTCF, MZF1, ETS2, MXD1, USF2, SP1, ID2, TAL1, SMAD3, DNMT1, E2F1, WT1, ESR2, HDAC1, JUN, TP53, RELA, NFKB1, TP73, ETS1, HIF1A, STAT3, MEN1, NFATC2, FLI1, USF1, ESR1, MYC, PITX1, MYCN	0
GATA2	YES	1	NANOG	0
KRAS	YES	1	MYC	0
ETV6	YES	1	STAT3	0
KIT	YES	4	SP1, TFAP2A, MITF, RBMX	0
RUNX1	YES	4	HLF, RUNX3, L3MBTL1, PITX1	0
ELANE	NO	7	RUNX2, LEF1, SPI1, GFI1, MYB, CEBPA, RUNX1	2	RUNX1, CEBPA
GATA1	NO	10	CBFB, CEBPE, POU2F1, SPI1, GATA2, FLI1, MYB, BCL11A, GATA1, MYC	2	CBFB, GATA2
CSF1	NO	8	CEBPA, SPI1, PPARG, NFKB1, JUN, ABL1, RELA, RUNX1	2	RUNX1, CEBPA
CDKN1A	NO	118	ABL1, TFAP4, TP53, MYF5, TCF3, HDAC9, PAX5, ZBTB2, LCOR, E2F3, ZBTB5, HSF1, ELL, TSC22D3, NCOA1, TAF1, RELA, MYOD1, STAT1, PTTG1, KLF16, ESR1, JUNB, MYCN, KAT2B, AR, BCL6, KLF10, EZH2, ARID1A, JUND, SP1, CEBPB, ZFHX3, ZNF300, EGR1, KLF4, AATF, HDAC7, HBP1, SMARCA4, ESR2, FOXP3, RARA, NELFCD, ING4, HDAC4, TBX2, IRF1, HDAC2, ETV6, SIRT2, MYOG, KLF6, TP73, SOX6, ATM, ERCC2, SMAD4, ETS2, NUPR1, PTMA, MLLT10, SMAD3, ETS1, CBX8, BRCA1, HIPK2, SIRT1, WT1, ZNF76, HDAC1, SMAD2, MLLT3, TFAP2A, EP300, FHL2, TP63, IRF9, EHMT2, TFAP2C, NFIX, RUNX3, RB1, HNF4A, NFIB, TAF5, SOX9, TBP, EAPP, ZBTB17, TAF4, REL, RELB, PML, SMAD7, NPM1, POU5F1, E2F1, TBX3, FOXG1, MYF6, NFIA, ATF2, PARP1, NFKB1, STAT3, GFI1, NR3C1, CREBBP, MTA1, JUN, KLF2, CDX2, SP3, MYC, PPARG, ING1	3	MLLT10, ETV6, NPM1
SPI1	NO	9	CEBPE, FOS, HOXC13, SATB1, JUN, GATA1, RUNX1, GATA2, POU2F2	2	GATA2, RUNX1
IL3	NO	12	SP1, VEZF1, CEBPA, EGR1, RUNX1T1, CEBPB, JUN, DNMT1, JUND, RUNX1, JUNB, ETS1	2	RUNX1, CEBPA
MAD2L1	NO	4	BRCA1, RUNX1, ETV6, POU2F1	2	RUNX1, ETV6

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
SETBP1	CHIC2	No	1	PLEKHF2
SETBP1	NPM1	No	2	APP, PPP2CA
SETBP1	WHSC1L1	No	1	UBE2I
SETBP1	NUP214	No	1	UBE2I
SETBP1	KRAS	No	1	APP
SETBP1	ETV6	No	1	UBE2I
SH3GL1	CHIC2	No	1	ITSN2
SH3GL1	CEBPA	No	1	EWSR1
SH3GL1	NPM1	No	7	CALU, AURKA, RPA1, EWSR1, NSUN2, PML, YWHAZ
SH3GL1	TERT	No	3	PML, PFDN1, YWHAZ
SH3GL1	LPP	No	5	SH3GLB1, CALR, ARPC4, TPRKB, NIF3L1
SH3GL1	GATA2	No	1	PML
SH3GL1	KRAS	No	1	PML
SH3GL1	KIT	No	1	PTPRO
SH3GL1	RUNX1	No	3	PML, PRMT1, CREBBP
SH3GL1	PICALM	No	2	EWSR1, SH3GLB2
FLT3	NPM1	No	4	SIAH1, GRB2, PIK3R1, HSP90AA1
FLT3	JAK2	No	5	PIK3R1, GRB2, IKBKG, SOCS1, HSP90AA1
FLT3	TERT	No	1	HSP90AA1
FLT3	ETV6	No	2	GRB2, SOCS1
FLT3	DDX41	No	1	SIAH1
FLT3	KIT	No	4	GRB2, SOCS1, PIK3R1, CBL
FLT3	RUNX1	No	2	SIAH1, UBE2L6
CHIC2	CEBPA	No	1	ELAVL1
CHIC2	CBFB	No	1	ELAVL1
CHIC2	MLLT10	No	1	ELAVL1
CHIC2	LPP	No	1	ELAVL1
CHIC2	GATA2	No	6	KRTAP10-9, ELAVL1, KRTAP10-3, MDFI, KRT40, NOTCH2NL
CHIC2	KRAS	No	2	ELAVL1, MDFI
CHIC2	ETV6	No	1	ELAVL1
CHIC2	RUNX1	No	1	ELAVL1
CEBPA	NPM1	No	12	CDKN1A, SMARCA4, CDK2, HDAC1, HDAC2, RARA, EWSR1, RB1, ESR1, PARP1, C1QBP, CHD1
CEBPA	WHSC1L1	No	3	SMARCA2, ESR1, SMARCA4
CEBPA	CBFB	No	2	MYC, ELAVL1
CEBPA	JAK2	No	1	SKP2
CEBPA	NUP214	No	3	SMAD3, RANBP2, SMAD4
CEBPA	TERT	No	2	XRCC6, XRCC5
CEBPA	MLLT10	No	1	ELAVL1
CEBPA	LPP	No	2	UBE3A, ELAVL1
CEBPA	GATA2	No	5	JUN, ZBTB16, ELAVL1, SPI1, SMAD4
CEBPA	KRAS	No	2	HNRNPC, ELAVL1
CEBPA	ETV6	No	2	KAT5, ELAVL1
CEBPA	RUNX1	No	12	SPI1, VDR, HDAC1, HDAC2, ELAVL1, CEBPB, JUN, SMAD3, RARA, SMARCA4, MYC, FOS
CEBPA	NSD1	No	4	VDR, AR, ESR1, RARA
CEBPA	PICALM	No	1	EWSR1
NPM1	WHSC1L1	No	9	HIST3H3, ESR1, HIST1H1A, HIST1H4A, AKT1, SMARCA4, CDKN2A, HIST1H3A, GLYR1
NPM1	CBFB	No	1	CUL5
NPM1	JAK2	No	9	PLCG1, PPP1CC, HIST3H3, PIK3R1, HSP90AA1, NAP1L1, HSP90AB1, BRCA1, GRB2
NPM1	NUP214	No	19	CUL2, OBSL1, CUL7, IPO5, HDAC5, NUP62, SIRT7, CFL1, XPO1, NXF1, RPL19, REV, TRIM28, FBXO6, NTRK1, EEF1A1, CUL3, G3BP1, ITGA4
NPM1	TERT	No	15	EIF2S1, NAT10, RELA, MDM2, ANXA2, SERBP1, HSPA4, HSP90AA1, DYRK2, YWHAZ, AKT1, NCL, YWHAQ, PML, ENO1
NPM1	MLF1	No	3	AKAP11, KIF11, MAP1B
NPM1	MLLT10	No	2	AFF1, DOT1L
NPM1	LPP	No	4	PPP2R1A, HSPA5, COPS5, XPO1
NPM1	GATA2	No	6	GOLGA2, CUL1, AKT1, HDAC5, EP300, PML
NPM1	KRAS	No	7	PHB, DDX50, PML, RPS29, DDX47, EEF1A1, APP
NPM1	ETV6	No	1	GRB2
NPM1	DDX41	No	7	OBSL1, SIAH1, MOV10, USP36, NTRK1, NXF1, CUL3
NPM1	KIT	No	6	PLCG1, GRB7, CLTC, CD81, PIK3R1, GRB2
NPM1	RUNX1	No	9	ELF4, HDAC1, HDAC2, RARA, SIAH1, SMARCA4, TAT, EP300, PML
NPM1	NSD1	No	11	AFF1, HIST3H3, RELA, HIST1H1D, HIST1H1C, SIRT7, HIST1H1B, RARA, ESR1, HIST1H3A, HIST1H4A
NPM1	PICALM	No	13	FN1, FUS, MCM2, VCAM1, PLCG1, XPO1, EWSR1, ITGA4, CLTC, NTRK1, EEF1A1, DDX1, SIRT1
WHSC1L1	JAK2	No	1	HIST3H3
WHSC1L1	NUP214	No	1	UBE2I
WHSC1L1	TERT	No	1	AKT1
WHSC1L1	MLLT10	No	1	YEATS4
WHSC1L1	GATA2	No	1	AKT1
WHSC1L1	ETV6	No	1	UBE2I
WHSC1L1	RUNX1	No	2	SMARCC1, SMARCA4
WHSC1L1	NSD1	No	4	HIST1H3A, HIST3H3, ESR1, HIST1H4A
CBFB	JAK2	No	1	PPIA
CBFB	TERT	No	1	PPIA
CBFB	MLLT10	No	1	ELAVL1
CBFB	LPP	No	1	ELAVL1
CBFB	GATA2	No	1	ELAVL1
CBFB	KRAS	No	2	ELAVL1, SERPINB5
CBFB	ETV6	No	1	ELAVL1
CBFB	RUNX1	Yes	7	KMT2A, ELAVL1, COPRS, MYOD1, MYC, RUNX1, VIF
CBFB	PICALM	No	1	SLC25A32
JAK2	NUP214	No	1	KPNB1
JAK2	TERT	No	2	PPIA, HSP90AA1
JAK2	LPP	No	1	VHL
JAK2	KRAS	No	4	TRAF6, CALM1, RAF1, DNAJA3
JAK2	ETV6	No	3	GRB2, SOCS1, SOCS3
JAK2	KIT	Yes	14	PTPN11, PTPN6, PIK3R1, PLCG1, TEC, STAT5B, JAK2, GRB10, SOCS1, LYN, JAK3, SRC, GRB2, STAT1
JAK2	RUNX1	No	1	TRAF6
JAK2	NSD1	No	1	HIST3H3
JAK2	PICALM	No	2	PLCG1, EGFR
NUP214	MLLT10	No	1	UBE2I
NUP214	LPP	No	1	XPO1
NUP214	GATA2	No	2	HDAC5, SMAD4
NUP214	KRAS	No	2	EEF1A1, NUP107
NUP214	ETV6	No	3	HDAC9, UBE2I, SOX2
NUP214	DDX41	No	4	NTRK1, NXF1, OBSL1, CUL3
NUP214	RUNX1	No	4	SMAD1, SMAD3, SMAD2, SOX2
NUP214	NSD1	No	1	SIRT7
NUP214	PICALM	No	5	NTRK1, EEF1A1, ITGA4, XPO1, SOX2
TERT	GATA2	No	2	PML, AKT1
TERT	KRAS	No	1	PML
TERT	RUNX1	No	2	PML, STUB1
TERT	NSD1	No	1	RELA
MLF1	KRAS	No	1	PDE4DIP
MLLT10	LPP	No	1	ELAVL1
MLLT10	GATA2	No	1	ELAVL1
MLLT10	KRAS	No	1	ELAVL1
MLLT10	ETV6	No	1	ELAVL1
MLLT10	RUNX1	No	2	SMARCB1, ELAVL1
MLLT10	NSD1	No	1	AFF1
LPP	GATA2	No	1	ELAVL1
LPP	KRAS	No	1	ELAVL1
LPP	ETV6	No	1	ELAVL1
LPP	RUNX1	No	1	ELAVL1
LPP	PICALM	Yes	2	NPLOC4, XPO1
GATA2	KRAS	No	4	PML, PSMA3, ELAVL1, MDFI
GATA2	ETV6	No	3	HDAC3, SKP1, ELAVL1
GATA2	RUNX1	No	8	CDK1, SPI1, PML, HDAC3, ELAVL1, JUN, TAL1, EP300
KRAS	ETV6	No	1	ELAVL1
KRAS	KIT	No	2	PIK3CG, PIK3R2
KRAS	RUNX1	No	3	PML, TRAF6, ELAVL1
KRAS	PICALM	No	3	UNK, EEF1A1, LIMA1
ETV6	DDX41	No	1	HDAC6
ETV6	KIT	No	3	GRB2, SOCS1, CRKL
ETV6	RUNX1	No	5	SIN3A, HDAC3, NCOR1, ELAVL1, SOX2
ETV6	PICALM	No	1	SOX2
DDX41	RUNX1	No	1	SIAH1
DDX41	PICALM	No	3	NTRK1, SNW1, CDC5L
KIT	PICALM	No	2	PLCG1, CLTC
RUNX1	NSD1	No	2	VDR, RARA
RUNX1	PICALM	No	1	SOX2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
SETBP1	NUP214	No	-	1	SET
SH3GL1	FLT3	No	-	2	UBC, CBL
SH3GL1	CHIC2	No	-	1	UBC
SH3GL1	CEBPA	No	-	2	UBC, CREBBP
SH3GL1	NPM1	No	-	1	UBC
SH3GL1	CBFB	No	-	1	UBC
SH3GL1	JAK2	No	-	9	KIT, CBL, CBLC, UBC, EGFR, SRC, CBLB, FYN, YES1
SH3GL1	TERT	No	-	4	SRC, UBC, CREBBP, EGFR
SH3GL1	KRAS	No	-	8	KIT, RET, UBC, YES1, EGFR, SRC, FYN, ERBB4
SH3GL1	ETV6	No	-	1	UBC
SH3GL1	DDX41	No	-	1	UBC
SH3GL1	KIT	Yes	activation, binding	10	CREBBP, CBLC, SH3KBP1, UBC, CBL, SH3GL2, SRC, CBLB, FYN, YES1
SH3GL1	RUNX1	No	-	3	UBC, CREBBP, CSF1R
SH3GL1	PICALM	No	-	4	UBC, SYNJ1, BIN2, DNM1
FLT3	CHIC2	No	-	1	UBC
FLT3	CEBPA	Yes	inhibition, binding	5	SPI1, UBC, PTPN11, SIRT1, CTNNB1
FLT3	NPM1	No	-	4	UBC, GRB2, SIRT1, AKT1
FLT3	CBFB	No	-	1	UBC
FLT3	JAK2	No	-	21	STAT5B, STAT3, STAT5A, PIK3R3, SPI1, PTPN12, PIK3R5, SOCS6, PHLPP2, PIK3CA, PHLPP1, PIK3CB, GRB2, PIK3CG, UBC, HSP90AA1, PIK3CD, SOCS1, SOCS2, CBL, PTPN11
FLT3	TERT	No	-	7	STAT3, AKT1, PTPN11, HSP90AA1, CTNNB1, UBC, SIRT1
FLT3	MLLT10	No	-	1	CTNNB1
FLT3	KRAS	No	-	9	PTPN11, PIK3CG, PIK3CA, PIK3CB, HSP90AA1, AKT1, UBC, GRB2, PIK3CD
FLT3	ETV6	No	-	2	UBC, NCOR1
FLT3	DDX41	No	-	2	UBC, PTPN11
FLT3	KIT	No	-	20	STAT5B, STAT3, PHLPP2, PHLPP1, SPI1, PTPN11, CBL, SOCS6, PIK3CB, HSP90AA1, PIK3R3, STAT5A, MYB, PIK3CA, PIK3CG, UBC, PIK3CD, SOCS1, PIK3R5, GRB2
FLT3	RUNX1	No	-	8	PTPN11, CEBPA, SPI1, STAT5B, STAT5A, UBC, PIM1, NCOR1
FLT3	NSD1	No	-	1	MEIS1
FLT3	PICALM	No	-	1	UBC
CHIC2	CEBPA	No	-	1	UBC
CHIC2	NPM1	No	-	1	UBC
CHIC2	CBFB	No	-	1	UBC
CHIC2	JAK2	No	-	1	UBC
CHIC2	TERT	No	-	1	UBC
CHIC2	KRAS	No	-	1	UBC
CHIC2	ETV6	No	-	1	UBC
CHIC2	DDX41	No	-	1	UBC
CHIC2	KIT	No	-	1	UBC
CHIC2	RUNX1	No	-	1	UBC
CHIC2	PICALM	No	-	1	UBC
CEBPA	NPM1	No	-	11	CDKN1A, BCL2, CDK2, ATF5, RARA, UBC, RB1, CDK4, MAX, MYC, SIRT1
CEBPA	CBFB	No	-	4	UBC, FOS, RUNX1, ATF2
CEBPA	JAK2	No	-	9	PTPN11, BCL2, SPI1, PRL, KLK3, UBC, LEP, FOS, MYC
CEBPA	NUP214	No	-	1	HDAC1
CEBPA	TERT	No	-	14	SP1, PTPN11, CTNNB1, EP300, HDAC1, RB1, MAX, JUN, ESR1, UBC, MYC, FOS, CREBBP, SIRT1
CEBPA	MLLT10	No	-	1	CTNNB1
CEBPA	KRAS	No	-	11	PTPN11, BCL2, MAPK11, ETS2, JUN, CEBPD, MAPK13, UBC, MAPK14, MAPK12, ETS1
CEBPA	ETV6	No	-	1	UBC
CEBPA	DDX41	No	-	5	UBC, PTPN11, FOS, CDK2, BCL2
CEBPA	KIT	No	-	6	PTPN11, SPI1, CREBBP, ETS2, UBC, MYC
CEBPA	RUNX1	Yes	activation, binding	14	SP1, CREBBP, PTPN11, SPI1, EP300, HDAC1, CDKN1A, RARA, CEBPB, JUN, UBC, FOS, RUNX1T1, ETS1
CEBPA	NSD1	No	-	1	ESR1
CEBPA	PICALM	No	-	1	UBC
NPM1	CBFB	No	-	1	UBC
NPM1	JAK2	No	-	6	BCL2, HRAS, INS, UBC, GRB2, MYC
NPM1	NUP214	Yes	binding	26	MDM2, NUP37, RAN, NUP35, NUP160, NUP88, NUP85, NUP93, SUMO1, AAAS, RAE1, NUP153, TPR, KPNB1, NUP133, NUP107, NUP205, NUP210, NUP155, NUP188, NUP43, NUP62, NUP50, NUP54, RANBP2, NUPL2
NPM1	TERT	No	-	17	HIF1A, RUVBL1, ABL1, ARNT, IRF1, TP53, UBC, RB1, MDM2, RBBP7, AKT1, NCL, MAX, MYC, RBBP4, MTOR, SIRT1
NPM1	MLF1	No	-	2	MLF1IP, PLK1
NPM1	KRAS	Yes	binding	10	AKT1, BCL2, HRAS, ABL1, MTOR, TP53, CTGF, UBC, GRB2, NCL
NPM1	ETV6	No	-	3	UBC, SUMO2, SUMO1
NPM1	DDX41	No	-	4	UBC, INS, CDK2, BCL2
NPM1	KIT	No	-	7	MDM2, HRAS, KRAS, INS, UBC, GRB2, MYC
NPM1	RUNX1	No	-	6	CDKN1A, CDK6, PML, TP53, RARA, UBC
NPM1	PICALM	No	-	1	UBC
CBFB	JAK2	No	-	2	UBC, FOS
CBFB	NUP214	No	-	2	SMAD3, SMAD4
CBFB	TERT	No	-	3	UBC, FOS, SMAD3
CBFB	KRAS	No	-	1	UBC
CBFB	ETV6	No	-	1	UBC
CBFB	DDX41	No	-	2	UBC, FOS
CBFB	KIT	No	-	1	UBC
CBFB	RUNX1	Yes	binding	5	RUNX3, UBC, SMAD3, FOS, SMAD4
CBFB	PICALM	No	-	1	UBC
JAK2	TERT	No	-	16	WT1, STAT3, IFNAR2, IL2, KITLG, NFKB1, MAPK1, PTPN11, IFNG, UBC, HSP90AA1, EGFR, SRC, MYC, FOS, CDKN1B
JAK2	KRAS	No	-	34	BCL2L1, EGFR, MAPK3, PTPN11, IL8, BTRC, SHC2, PIK3CG, HBEGF, LGALS3, BCL2, PTK2, ERBB2, ERBB3, CCR5, RAF1, SOS1, SHC1, KIT, HRAS, PRMT5, HSP90AA1, SHC3, SRC, FYN, GRB2, YES1, MAPK1, PIK3CB, IRS1, IRS2, PIK3CA, UBC, PIK3CD
JAK2	ETV6	No	-	4	UBC, MAPK3, MAPK1, PDGFRB
JAK2	DDX41	No	-	11	PTPN11, STAT2, BCL2, VAV1, INS, ERBB2, PTK2, UBC, CCR7, FOS, BCAR1
JAK2	KIT	Yes	activation, binding	55	MYC, BCL2L1, KITLG, PLCG1, EPO, LYN, SHC2, PIK3CG, PDGFB, CBLB, BCR, STAT5B, GRB2, PHLPP2, SPI1, IL4, PIK3R5, SOCS6, STAT5A, PIK3CA, SOCS1, SHC4, SOS1, SHC1, SH2B3, CSF2, PHLPP1, LCK, HRAS, IL2, GAB2, HSP90AA1, PIK3CB, VAV1, PIK3R3, SRC, FYN, GAB1, YES1, STAT3, SOCS7, PTPN11, CBL, TEC, SHC3, CBLC, INS, IL3, PIK3R1, CRKL, UBC, IRS1, PIK3CD, CXCL12, EPOR
JAK2	RUNX1	No	-	10	PTPN11, STAT5A, PDGFRB, SPI1, CSF2, MPL, STAT5B, UBC, CCL3, FOS
JAK2	PICALM	No	-	1	UBC
NUP214	TERT	No	-	3	HDAC1, SMAD3, MDM2
NUP214	MLF1	No	-	1	XPO1
NUP214	KRAS	No	-	1	NPM1
NUP214	ETV6	No	-	1	SUMO1
NUP214	KIT	No	-	2	MAPK8, MDM2
NUP214	RUNX1	No	-	5	SMAD1, HDAC1, SMAD3, SMAD2, SMAD4
TERT	MLLT10	No	-	1	CTNNB1
TERT	KRAS	No	-	15	HSP90AA1, PTPN11, AKT1, CCND1, ABL1, MAPK1, JUN, TP53, UBC, RPS6KB1, MTOR, EGFR, SRC, EGF, NCL
TERT	ETV6	No	-	3	UBC, SIN3A, MAPK1
TERT	DDX41	No	-	3	UBC, PTPN11, FOS
TERT	KIT	No	-	14	MYC, PTPN11, IL2, KITLG, CREBBP, STAT3, HSP90AA1, EGF, RPS6KB1, MDM2, PRKCA, SRC, FGF2, UBC
TERT	RUNX1	No	-	12	SP1, PTPN11, EP300, HDAC1, HDAC2, TP53, JUN, SMAD3, UBC, SIN3A, FOS, CREBBP
TERT	NSD1	No	-	1	ESR1
TERT	PICALM	No	-	1	UBC
LPP	KRAS	No	-	1	SPTA1
KRAS	ETV6	No	-	4	UBC, MAPK1, NOTCH1, MAPK3
KRAS	DDX41	No	-	5	UBC, ERBB2, PTK2, PTPN11, BCL2
KRAS	KIT	Yes	catalysis, binding, activation	25	BCL2L1, BMP4, PTPN11, ETS2, SHC2, PIK3CG, NCAM1, FYN, ANGPT1, PIK3CA, SOS1, SHC1, HRAS, HSP90AA1, UBC, SHC3, PIK3CB, SRC, VEGFA, GRB2, YES1, RPS6KB1, IRS1, EGF, PIK3CD
KRAS	RUNX1	No	-	9	PTPN11, PRMT1, BMP4, TP53, JUN, MECOM, UBC, NCAM1, ETS1
KRAS	NSD1	No	-	1	BMP4
KRAS	PICALM	No	-	1	UBC
ETV6	DDX41	No	-	1	UBC
ETV6	KIT	No	-	1	UBC
ETV6	RUNX1	No	-	4	UBC, SIN3A, NCOR1, PDGFRB
ETV6	PICALM	No	-	1	UBC
DDX41	KIT	No	-	4	UBC, INS, PTPN11, VAV1
DDX41	RUNX1	No	-	3	UBC, PTPN11, FOS
DDX41	PICALM	No	-	1	UBC
KIT	RUNX1	No	-	11	CSF2, STAT5A, SPI1, BMP4, CREBBP, PTPN11, TAL1, STAT5B, DNMT1, UBC, NCAM1
KIT	NSD1	No	-	1	BMP4
KIT	PICALM	No	-	3	EPS15, UBC, EPN1
RUNX1	NSD1	No	-	1	BMP4
RUNX1	PICALM	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
NPM1	DDX41	No	-	9	SNU13, HNRNPR, HNRNPA1, PABPC1, HNRNPM, U2AF1, U2AF2, HNRNPU, DHX9
CBFB	RUNX1	Yes	RUNX1-CBF-beta-DNA complex	0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
NUP214	PICALM	No	1	EEF1A1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
CBFB	RUNX1	Yes	2	CBFB, RUNX1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Pathways in cancer	hsa05200	3.98	5	KIT, FLT3, RUNX1, KRAS, CEBPA
Acute myeloid leukemia	hsa05221	6.74	5	KIT, FLT3, RUNX1, KRAS, CEBPA
Transcriptional misregulation in cancer	hsa05202	5.21	5	ETV6, FLT3, RUNX1, CEBPA, MLF1
Central carbon metabolism in cancer	hsa05230	6.7	3	KIT, KRAS, FLT3
PI3K-Akt signaling pathway	hsa04151	4.21	3	KIT, KRAS, JAK2
Lysine degradation	hsa00310	7.01	2	WHSC1L1, NSD1
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6	2	KRAS, JAK2
Dorso-ventral axis formation	hsa04320	8.01	2	ETV6, KRAS
Rap1 signaling pathway	hsa04015	4.97	2	KIT, KRAS
Ras signaling pathway	hsa04014	4.9	2	KIT, KRAS
Cholinergic synapse	hsa04725	5.88	2	KRAS, JAK2
Endocytosis	hsa04144	4.92	2	SH3GL1, KIT
Hematopoietic cell lineage	hsa04640	6.18	2	KIT, FLT3
Chronic myeloid leukemia	hsa05220	6.48	2	RUNX1, KRAS
Melanogenesis	hsa04916	5.97	2	KIT, KRAS
HTLV-I infection	hsa05166	4.59	2	KRAS, TERT
Chemokine signaling pathway	hsa04062	5.19	2	KRAS, JAK2
Cytokine-cytokine receptor interaction	hsa04060	4.67	2	KIT, FLT3
Prolactin signaling pathway	hsa04917	6.6	2	KRAS, JAK2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Cancers: Overview	NEW	2.72	0.007	PICALM, KRAS, KIT, CEBPA, GATA2, ETV6, LPP, JAK2, MLLT10, MLF1, FLT3, NPM1, RUNX1, NSD1
Cancers: Specific types	NEW	4.1	0.005	KRAS, KIT, CEBPA, GATA2, JAK2, ETV6, FLT3, NPM1, RUNX1
Central carbon metabolism in cancer (hsa05230)	-	6.7	0.022	KIT, KRAS, FLT3
Acute myeloid leukemia (hsa05221)	-	6.74	0.0	KIT, CEBPA, KRAS, JAK2, FLT3, RUNX1
Transcriptional misregulation in cancer (hsa05202)	-	5.21	0.001	PICALM, CEBPA, GATA2, ETV6, JAK2, MLLT10, MLF1, FLT3, NPM1, RUNX1, NSD1

REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Immune System	R-HSA-168256	2.37	5	JAK2, DDX41, KIT, KRAS, NUP214
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	4	JAK2, KIT, KRAS, NUP214
Signal Transduction	R-HSA-162582	1.78	4	JAK2, KIT, TERT, KRAS
Innate Immune System	R-HSA-168249	3.17	4	DDX41, KIT, JAK2, KRAS
Disease	R-HSA-1643685	3.33	4	KIT, KRAS, NUP214, NPM1
Developmental Biology	R-HSA-1266738	3.48	4	KRAS, KIT, JAK2, CEBPA
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	3	KIT, KRAS, JAK2
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	3	KIT, KRAS, JAK2
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	3	KIT, KRAS, JAK2
Signaling by Interleukins	R-HSA-449147	4.71	3	KIT, JAK2, KRAS
Interleukin-2 signaling	R-HSA-451927	5.05	3	KIT, KRAS, JAK2
Frs2-mediated activation	R-HSA-170968	5.12	3	KIT, JAK2, KRAS
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	3	KIT, JAK2, KRAS
SOS-mediated signalling	R-HSA-112412	5.15	3	KIT, JAK2, KRAS
IGF1R signaling cascade	R-HSA-2428924	4.85	3	KIT, JAK2, KRAS
Downstream signal transduction	R-HSA-186763	4.65	3	KIT, JAK2, KRAS
Cell Cycle	R-HSA-1640170	3.89	3	TERT, NUP214, NPM1
Signaling by ERBB4	R-HSA-1236394	4.7	3	KIT, KRAS, JAK2
ARMS-mediated activation	R-HSA-170984	5.12	3	KIT, JAK2, KRAS
Signaling by Insulin receptor	R-HSA-74752	4.73	3	KIT, JAK2, KRAS
RAF/MAP kinase cascade	R-HSA-5673001	5.15	3	KIT, KRAS, JAK2
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	3	KIT, JAK2, KRAS
MAPK family signaling cascades	R-HSA-5683057	4.89	3	KIT, KRAS, JAK2
Signalling by NGF	R-HSA-166520	4.23	3	KIT, KRAS, JAK2
Signaling by VEGF	R-HSA-194138	4.66	3	KIT, KRAS, JAK2
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	3	KIT, KRAS, JAK2
FCERI mediated MAPK activation	R-HSA-2871796	4.32	3	KIT, JAK2, KRAS
IRS-mediated signalling	R-HSA-112399	4.87	3	KIT, KRAS, JAK2
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	3	KIT, JAK2, KRAS
DAP12 interactions	R-HSA-2172127	4.56	3	KIT, KRAS, JAK2
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	3	KIT, JAK2, KRAS
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	3	KIT, JAK2, KRAS
Insulin receptor signalling cascade	R-HSA-74751	4.85	3	KIT, KRAS, JAK2
Signaling by FGFR4	R-HSA-5654743	4.69	3	KIT, JAK2, KRAS
Signaling by FGFR3	R-HSA-5654741	4.69	3	KIT, KRAS, JAK2
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	3	KIT, JAK2, KRAS
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	3	KIT, JAK2, KRAS
Signaling by FGFR	R-HSA-190236	4.67	3	KIT, JAK2, KRAS
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	3	KIT, KRAS, JAK2
Signaling by Leptin	R-HSA-2586552	5.1	3	KIT, KRAS, JAK2
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	3	KIT, JAK2, KRAS
Interleukin receptor SHC signaling	R-HSA-912526	5.09	3	KIT, KRAS, JAK2
Signaling by SCF-KIT	R-HSA-1433557	4.73	3	KIT, JAK2, KRAS
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	3	KIT, KRAS, JAK2
Signaling by PDGF	R-HSA-186797	4.53	3	KIT, JAK2, KRAS
Signalling to RAS	R-HSA-167044	5.08	3	KIT, KRAS, JAK2
DAP12 signaling	R-HSA-2424491	4.64	3	KIT, KRAS, JAK2
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	3	KIT, JAK2, KRAS
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	3	KIT, KRAS, JAK2
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	3	KIT, KRAS, JAK2
SHC1 events in EGFR signaling	R-HSA-180336	5.15	3	KIT, KRAS, JAK2
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	3	KIT, KRAS, JAK2
Chromatin modifying enzymes	R-HSA-3247509	5.19	3	WHSC1L1, JAK2, NSD1
Prolonged ERK activation events	R-HSA-169893	5.11	3	KIT, JAK2, KRAS
Signalling to ERKs	R-HSA-187687	5.04	3	KIT, JAK2, KRAS
Signaling by GPCR	R-HSA-372790	2.68	3	KIT, JAK2, KRAS
Signaling by FGFR2	R-HSA-5654738	4.68	3	KIT, JAK2, KRAS
GRB2 events in EGFR signaling	R-HSA-179812	5.15	3	KIT, JAK2, KRAS
Signaling by FGFR1	R-HSA-5654736	4.69	3	KIT, JAK2, KRAS
Signaling by EGFR	R-HSA-177929	4.59	3	KIT, KRAS, JAK2
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	3	KIT, KRAS, JAK2
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	3	KIT, JAK2, KRAS
Chromatin organization	R-HSA-4839726	5.19	3	WHSC1L1, JAK2, NSD1
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	3	KIT, JAK2, KRAS
Signaling by ERBB2	R-HSA-1227986	4.66	3	KIT, JAK2, KRAS
Axon guidance	R-HSA-422475	3.93	3	KIT, JAK2, KRAS
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	3	KIT, JAK2, KRAS
Hemostasis	R-HSA-109582	3.98	3	GATA2, KRAS, JAK2
Infectious disease	R-HSA-5663205	4.47	2	NPM1, NUP214
Host Interactions of HIV factors	R-HSA-162909	5.99	2	NPM1, NUP214
Nuclear import of Rev protein	R-HSA-180746	8.03	2	NPM1, NUP214
Interactions of Rev with host cellular proteins	R-HSA-177243	7.89	2	NPM1, NUP214
Diseases of signal transduction	R-HSA-5663202	4.89	2	KIT, KRAS
Transmembrane transport of small molecules	R-HSA-382551	3.79	2	RUNX1, NUP214
HIV Infection	R-HSA-162906	5.22	2	NPM1, NUP214
SLC-mediated transmembrane transport	R-HSA-425407	4.95	2	RUNX1, NUP214
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62	2	KIT, KRAS
PKMTs methylate histone lysines	R-HSA-3214841	7.66	2	WHSC1L1, NSD1
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59	2	KIT, KRAS
Interferon Signaling	R-HSA-913531	4.95	2	JAK2, NUP214
Chromosome Maintenance	R-HSA-73886	6.56	2	NPM1, TERT
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.88	2	GATA2, JAK2
Adaptive Immune System	R-HSA-1280218	3.19	2	KIT, KRAS
RAF activation	R-HSA-5673000	8.34	2	KRAS, JAK2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	23	CBFB, NUP214, GATA2, CHIC2, JAK2, LPP, ETV6, RUNX1, CEBPA, TGM6, KRAS, MLLT10, KIT, FLT3, DDX41, NPM1, SETBP1, WHSC1L1, PICALM, MLF1, TERT, SH3GL1, NSD1
protein binding (GO:0005515)	0.46	22	CHIC2, NUP214, GATA2, CBFB, JAK2, LPP, MLF1, RUNX1, CEBPA, KRAS, MLLT10, KIT, FLT3, DDX41, NPM1, SETBP1, WHSC1L1, PICALM, ETV6, TERT, SH3GL1, NSD1
organic cyclic compound binding (GO:0097159)	1.05	16	CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, SETBP1, RUNX1, GATA2, NSD1
heterocyclic compound binding (GO:1901363)	1.06	16	CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, SETBP1, RUNX1, GATA2, NSD1
cation binding (GO:0043169)	1.4	12	KRAS, KIT, GATA2, TGM6, JAK2, LPP, MLLT10, NSD1, TERT, RUNX1, DDX41, WHSC1L1
metal ion binding (GO:0046872)	1.41	12	KRAS, KIT, GATA2, TGM6, JAK2, LPP, MLLT10, NSD1, TERT, RUNX1, DDX41, WHSC1L1
nucleic acid binding (GO:0003676)	1.44	12	CBFB, CEBPA, GATA2, ETV6, MLLT10, MLF1, TERT, NPM1, SETBP1, RUNX1, DDX41, NSD1
ion binding (GO:0043167)	1.36	12	KRAS, KIT, GATA2, TGM6, JAK2, LPP, MLLT10, NSD1, TERT, RUNX1, DDX41, WHSC1L1
DNA binding (GO:0003677)	1.92	11	CBFB, CEBPA, DDX41, ETV6, MLLT10, MLF1, TERT, SETBP1, RUNX1, GATA2, NSD1
catalytic activity (GO:0003824)	1.05	10	KRAS, KIT, FLT3, TGM6, JAK2, NSD1, TERT, RUNX1, DDX41, WHSC1L1
transferase activity (GO:0016740)	1.95	7	KIT, FLT3, TGM6, JAK2, WHSC1L1, TERT, NSD1
identical protein binding (GO:0042802)	2.63	7	KIT, FLT3, CEBPA, NPM1, TERT, SH3GL1, RUNX1
sequence-specific DNA binding (GO:0043565)	2.79	6	CEBPA, GATA2, ETV6, TERT, RUNX1, NSD1
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
transcription factor binding (GO:0008134)	3.46	6	CEBPA, GATA2, NPM1, TERT, RUNX1, NSD1
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	6	CBFB, CEBPA, GATA2, ETV6, MLLT10, RUNX1
nucleotide binding (GO:0000166)	1.96	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
small molecule binding (GO:0036094)	1.89	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
carbohydrate derivative binding (GO:0097367)	2.03	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
ribonucleotide binding (GO:0032553)	2.19	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
nucleic acid binding transcription factor activity (GO:0001071)	2.65	6	CBFB, CEBPA, GATA2, ETV6, MLLT10, RUNX1
purine nucleoside binding (GO:0001883)	2.22	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
ribonucleoside binding (GO:0032549)	2.22	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
purine ribonucleotide binding (GO:0032555)	2.2	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
purine nucleotide binding (GO:0017076)	2.19	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
protein dimerization activity (GO:0046983)	2.72	6	KIT, TERT, CEBPA, NPM1, FLT3, RUNX1
nucleoside binding (GO:0001882)	2.21	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
purine ribonucleoside binding (GO:0032550)	2.22	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
nucleoside phosphate binding (GO:1901265)	1.96	6	KIT, DDX41, KRAS, JAK2, FLT3, RUNX1
protein homodimerization activity (GO:0042803)	3.16	6	KIT, TERT, CEBPA, NPM1, FLT3, RUNX1
transcription regulatory region DNA binding (GO:0044212)	3.03	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
transition metal ion binding (GO:0046914)	2.48	5	LPP, GATA2, WHSC1L1, MLLT10, NSD1
adenyl nucleotide binding (GO:0030554)	2.4	5	KIT, DDX41, RUNX1, FLT3, JAK2
regulatory region nucleic acid binding (GO:0001067)	3.03	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
regulatory region DNA binding (GO:0000975)	3.03	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
RNA polymerase II regulatory region DNA binding (GO:0001012)	3.36	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
transcription cofactor activity (GO:0003712)	3.44	5	CBFB, RUNX1, CEBPA, NSD1, NPM1
enzyme binding (GO:0019899)	2.27	5	SH3GL1, KIT, JAK2, CEBPA, NPM1
protein domain specific binding (GO:0019904)	3.32	5	ETV6, GATA2, KRAS, JAK2, MLF1
macromolecular complex binding (GO:0044877)	2.61	5	KRAS, GATA2, FLT3, NPM1, NSD1
zinc ion binding (GO:0008270)	2.66	5	LPP, GATA2, MLLT10, WHSC1L1, NSD1
transcription factor activity, transcription factor binding (GO:0000989)	3.36	5	CBFB, RUNX1, CEBPA, NSD1, NPM1
transcription factor activity, protein binding (GO:0000988)	3.35	5	CBFB, RUNX1, CEBPA, NSD1, NPM1
adenyl ribonucleotide binding (GO:0032559)	2.41	5	KIT, DDX41, RUNX1, FLT3, JAK2
double-stranded DNA binding (GO:0003690)	3.09	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
ATP binding (GO:0005524)	2.43	5	KIT, DDX41, RUNX1, FLT3, JAK2
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	3.37	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	4	FLT3, KIT, JAK2, TERT
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	3.98	4	GATA2, RUNX1, ETV6, CEBPA
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	4	GATA2, RUNX1, ETV6, CEBPA
hydrolase activity (GO:0016787)	1.9	3	DDX41, RUNX1, KRAS
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	3	KIT, FLT3, JAK2
kinase activity (GO:0016301)	2.93	3	KIT, FLT3, JAK2
transcription coactivator activity (GO:0003713)	4.04	3	CBFB, NPM1, CEBPA
kinase binding (GO:0019900)	3.32	3	CEBPA, JAK2, NPM1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077)	4.31	3	GATA2, ETV6, CEBPA
protein tyrosine kinase activity (GO:0004713)	4.54	3	KIT, FLT3, JAK2
core promoter binding (GO:0001047)	4.71	3	GATA2, RUNX1, NSD1
protein kinase activity (GO:0004672)	3.27	3	KIT, FLT3, JAK2
hormone receptor binding (GO:0051427)	4.57	3	FLT3, JAK2, NSD1
receptor binding (GO:0005102)	2.43	3	FLT3, JAK2, NSD1
molecular function regulator (GO:0098772)	2.51	3	KIT, NPM1, JAK2
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982)	3.94	3	GATA2, ETV6, CEBPA
RNA binding (GO:0003723)	2.36	3	DDX41, NPM1, TERT
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	4.31	2	KIT, JAK2
histone binding (GO:0042393)	4.72	2	JAK2, NPM1
histone methyltransferase activity (GO:0042054)	5.68	2	WHSC1L1, NSD1
histone-lysine N-methyltransferase activity (GO:0018024)	5.93	2	WHSC1L1, NSD1
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	2	KIT, JAK2
lysine N-methyltransferase activity (GO:0016278)	5.7	2	WHSC1L1, NSD1
protein-lysine N-methyltransferase activity (GO:0016279)	5.71	2	WHSC1L1, NSD1
molecular transducer activity (GO:0060089)	2.32	2	KIT, FLT3
protein methyltransferase activity (GO:0008276)	5.33	2	WHSC1L1, NSD1
receptor activity (GO:0004872)	2.32	2	KIT, FLT3
signal transducer activity (GO:0004871)	2.28	2	KIT, FLT3
methyltransferase activity (GO:0008168)	4.35	2	WHSC1L1, NSD1
transcription corepressor activity (GO:0003714)	4.33	2	RUNX1, NSD1
transmembrane receptor protein tyrosine kinase activity (GO:0004714)	5.55	2	KIT, FLT3
transferase activity, transferring one-carbon groups (GO:0016741)	4.3	2	WHSC1L1, NSD1
RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979)	5.77	2	GATA2, NSD1
core promoter proximal region sequence-specific DNA binding (GO:0000987)	3.83	2	ETV6, CEBPA
steroid hormone receptor binding (GO:0035258)	5.32	2	FLT3, NSD1
S-adenosylmethionine-dependent methyltransferase activity (GO:0008757)	4.81	2	WHSC1L1, NSD1
poly(A) RNA binding (GO:0044822)	2.69	2	DDX41, NPM1
nuclear hormone receptor binding (GO:0035257)	4.7	2	FLT3, NSD1
lipid binding (GO:0008289)	3.26	2	SH3GL1, PICALM
nucleoside-triphosphatase activity (GO:0017111)	3.09	2	DDX41, KRAS
protein kinase binding (GO:0019901)	3.44	2	JAK2, NPM1
protein complex binding (GO:0032403)	3.09	2	KRAS, FLT3
N-methyltransferase activity (GO:0008170)	5.26	2	WHSC1L1, NSD1
core promoter proximal region DNA binding (GO:0001159)	3.82	2	ETV6, CEBPA
core promoter sequence-specific DNA binding (GO:0001046)	5.12	2	GATA2, NSD1
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	3.88	2	ETV6, CEBPA
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	2	DDX41, KRAS
chromatin binding (GO:0003682)	3.64	2	GATA2, NSD1
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	2	DDX41, KRAS
transmembrane receptor protein kinase activity (GO:0019199)	5.32	2	KIT, FLT3
pyrophosphatase activity (GO:0016462)	3.04	2	DDX41, KRAS
transmembrane signaling receptor activity (GO:0004888)	2.57	2	KIT, FLT3
signaling receptor activity (GO:0038023)	2.49	2	KIT, FLT3
protein heterodimerization activity (GO:0046982)	3.64	2	RUNX1, NPM1
transmembrane receptor activity (GO:0099600)	2.53	2	KIT, FLT3

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
RNA polymerase II regulatory region DNA binding (GO:0001012)	-	3.36	0.024	CEBPA, GATA2, ETV6, NPM1, FLT3, RUNX1, NSD1
core promoter proximal region DNA binding (GO:0001159)	-	3.82	0.015	CEBPA, GATA2, ETV6, FLT3, RUNX1, NSD1
enhancer sequence-specific DNA binding (GO:0001158)	NEW	5.36	0.021	GATA2, RUNX1, NPM1, JAK2
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001077)	-	4.31	0.0	CEBPA, GATA2, ETV6, NPM1, FLT3, RUNX1, NSD1
DNA binding (GO:0003677)	-	1.92	0.0	CHIC2, KRAS, KIT, FLT3, CEBPA, NSD1, DDX41, CBFB, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, SETBP1, RUNX1, GATA2, WHSC1L1
sequence-specific DNA binding (GO:0043565)	-	2.79	0.024	KRAS, FLT3, CEBPA, GATA2, JAK2, ETV6, TERT, NPM1, RUNX1, NSD1
identical protein binding (GO:0042802)	-	2.63	0.046	KIT, FLT3, CEBPA, NPM1, TERT, SH3GL1, RUNX1
core promoter proximal region sequence-specific DNA binding (GO:0000987)	-	3.83	0.015	CEBPA, GATA2, ETV6, FLT3, RUNX1, NSD1
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity (GO:0000982)	-	3.94	0.004	CEBPA, GATA2, ETV6, NPM1, FLT3, RUNX1, NSD1
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981)	-	3.29	0.02	CEBPA, GATA2, JAK2, ETV6, FLT3, NPM1, RUNX1, NSD1
protein homodimerization activity (GO:0042803)	-	3.16	0.021	KIT, TERT, CEBPA, NPM1, FLT3, RUNX1
transcription factor binding (GO:0008134)	-	3.46	0.043	GATA2, RUNX1, CEBPA, NSD1, NPM1
regulatory region nucleic acid binding (GO:0001067)	-	3.03	0.011	FLT3, CEBPA, GATA2, JAK2, ETV6, TERT, NPM1, RUNX1, NSD1
enhancer binding (GO:0035326)	NEW	5.21	0.047	GATA2, RUNX1, NPM1, JAK2
transcription regulatory region DNA binding (GO:0044212)	-	3.03	0.01	FLT3, CEBPA, GATA2, JAK2, ETV6, TERT, NPM1, RUNX1, NSD1
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription (GO:0001228)	-	3.98	0.003	CEBPA, GATA2, ETV6, NPM1, FLT3, RUNX1, NSD1
transcription regulatory region sequence-specific DNA binding (GO:0000976)	-	3.24	0.006	CEBPA, GATA2, JAK2, ETV6, FLT3, NPM1, RUNX1, NSD1
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	-	3.37	0.024	CEBPA, GATA2, ETV6, NPM1, FLT3, RUNX1, NSD1
protein binding (GO:0005515)	-	0.46	0.002	CHIC2, KRAS, WHSC1L1, TERT, CEBPA, DDX41, NUP214, CBFB, ETV6, LPP, JAK2, MLLT10, MLF1, FLT3, NPM1, PICALM, KIT, SH3GL1, RUNX1, GATA2, NSD1
regulatory region DNA binding (GO:0000975)	-	3.03	0.011	FLT3, CEBPA, GATA2, JAK2, ETV6, TERT, NPM1, RUNX1, NSD1
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	-	3.88	0.013	CEBPA, GATA2, ETV6, FLT3, RUNX1, NSD1
protein domain specific binding (GO:0019904)	-	3.32	0.012	PICALM, KRAS, KIT, FLT3, CEBPA, GATA2, ETV6, LPP, JAK2, MLF1, TERT, RUNX1

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular macromolecule metabolic process (GO:0044260)	0.93	19	NSD1, KRAS, KIT, NUP214, CEBPA, RUNX1, GATA2, CBFB, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, FLT3, DDX41, TGM6, WHSC1L1
cellular process (GO:0009987)	0.26	19	CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, RUNX1, TGM6, WHSC1L1
cellular metabolic process (GO:0044237)	0.69	19	NSD1, KRAS, KIT, NUP214, CEBPA, RUNX1, GATA2, CBFB, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, FLT3, DDX41, TGM6, WHSC1L1
regulation of cellular process (GO:0050794)	0.5	19	CBFB, KRAS, KIT, NUP214, CEBPA, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, SH3GL1, RUNX1, GATA2, WHSC1L1
organic substance metabolic process (GO:0071704)	0.63	19	CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, RUNX1, TGM6, WHSC1L1
biological regulation (GO:0065007)	0.39	19	CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, FLT3, ETV6, JAK2, MLLT10, WHSC1L1, MLF1, TERT, NPM1, PICALM, SH3GL1, RUNX1, DDX41, NSD1
metabolic process (GO:0008152)	0.58	19	CBFB, KRAS, KIT, NUP214, CEBPA, RUNX1, GATA2, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, NSD1, DDX41, TGM6, WHSC1L1
macromolecule metabolic process (GO:0043170)	0.83	19	CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, DDX41, FLT3, ETV6, JAK2, MLLT10, WHSC1L1, MLF1, TERT, NPM1, PICALM, RUNX1, TGM6, NSD1
regulation of biological process (GO:0050789)	0.45	19	CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, FLT3, ETV6, JAK2, MLLT10, WHSC1L1, MLF1, TERT, NPM1, PICALM, SH3GL1, RUNX1, DDX41, NSD1
primary metabolic process (GO:0044238)	0.69	18	CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, NSD1, TGM6, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of macromolecule metabolic process (GO:0060255)	1.08	17	CBFB, KRAS, KIT, NUP214, CEBPA, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, NPM1, TERT, PICALM, RUNX1, GATA2, WHSC1L1
regulation of metabolic process (GO:0019222)	1.02	17	CBFB, KRAS, KIT, NUP214, CEBPA, NSD1, GATA2, FLT3, ETV6, MLLT10, JAK2, TERT, NPM1, PICALM, RUNX1, DDX41, WHSC1L1
regulation of cellular metabolic process (GO:0031323)	1.07	16	CBFB, KRAS, KIT, FLT3, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of primary metabolic process (GO:0080090)	1.08	16	CBFB, KRAS, KIT, FLT3, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of gene expression (GO:0010468)	1.37	16	CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, PICALM, ETV6, JAK2, MLLT10, NSD1, TERT, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of metabolic process (GO:0009893)	1.74	15	CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, NSD1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	15	CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, WHSC1L1
regulation of biosynthetic process (GO:0009889)	1.37	15	CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, WHSC1L1
positive regulation of cellular metabolic process (GO:0031325)	1.81	15	CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, NSD1
regulation of RNA metabolic process (GO:0051252)	1.52	15	CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, WHSC1L1
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	15	CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	15	CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	15	CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of cellular biosynthetic process (GO:0031326)	1.38	15	CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, WHSC1L1
regulation of transcription, DNA-templated (GO:0006355)	1.56	15	CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	15	CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
single-organism cellular process (GO:0044763)	0.65	15	CBFB, KRAS, KIT, NUP214, CEBPA, GATA2, FLT3, ETV6, JAK2, MLF1, TERT, NPM1, PICALM, RUNX1, DDX41
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	15	CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, WHSC1L1
regulation of RNA biosynthetic process (GO:2001141)	1.55	15	CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, WHSC1L1
positive regulation of biological process (GO:0048518)	1.2	15	CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
single-organism process (GO:0044699)	0.48	15	CBFB, KRAS, KIT, NUP214, CEBPA, DDX41, FLT3, ETV6, JAK2, MLF1, TERT, NPM1, PICALM, RUNX1, GATA2
positive regulation of cellular process (GO:0048522)	1.3	15	CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
developmental process (GO:0032502)	1.36	14	CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, PICALM, MLF1, JAK2, TERT, NPM1, SH3GL1, RUNX1, DDX41
nitrogen compound metabolic process (GO:0006807)	1.13	14	CBFB, KIT, NUP214, CEBPA, NSD1, DDX41, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, GATA2, WHSC1L1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	13	CBFB, NUP214, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, DDX41, WHSC1L1
nucleic acid metabolic process (GO:0090304)	1.46	13	CBFB, NUP214, CEBPA, NSD1, DDX41, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, GATA2, WHSC1L1
cellular aromatic compound metabolic process (GO:0006725)	1.3	13	CBFB, NUP214, CEBPA, NSD1, DDX41, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, GATA2, WHSC1L1
single-organism developmental process (GO:0044767)	1.49	13	CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, PICALM, MLF1, JAK2, TERT, NPM1, RUNX1, DDX41
cellular nitrogen compound metabolic process (GO:0034641)	1.22	13	CBFB, NUP214, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of gene expression (GO:0010628)	2.35	13	CBFB, KRAS, KIT, CEBPA, DDX41, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
negative regulation of biological process (GO:0048519)	1.33	13	PICALM, KRAS, KIT, NUP214, CEBPA, GATA2, ETV6, JAK2, MLF1, TERT, NPM1, RUNX1, NSD1
organic cyclic compound metabolic process (GO:1901360)	1.26	13	CBFB, NUP214, CEBPA, NSD1, DDX41, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, GATA2, WHSC1L1
heterocycle metabolic process (GO:0046483)	1.31	13	CBFB, NUP214, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, NPM1, RUNX1, DDX41, WHSC1L1
RNA metabolic process (GO:0016070)	1.59	12	CBFB, NUP214, CEBPA, NSD1, DDX41, ETV6, MLLT10, MLF1, TERT, RUNX1, GATA2, WHSC1L1
positive regulation of biosynthetic process (GO:0009891)	2.29	12	CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
cellular developmental process (GO:0048869)	1.82	12	CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, ETV6, JAK2, MLF1, TERT, NPM1, RUNX1
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	12	CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	12	CBFB, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, TERT, NPM1, RUNX1, DDX41, NSD1
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	12	CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
negative regulation of cellular process (GO:0048523)	1.41	12	PICALM, KRAS, KIT, CEBPA, GATA2, ETV6, JAK2, MLF1, TERT, NPM1, RUNX1, NSD1
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	11	CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
organic substance biosynthetic process (GO:1901576)	1.34	11	CBFB, CEBPA, NUP214, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	11	CBFB, CEBPA, GATA2, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, DDX41, NSD1
RNA biosynthetic process (GO:0032774)	1.84	11	CBFB, NUP214, CEBPA, GATA2, ETV6, MLF1, MLLT10, WHSC1L1, TERT, RUNX1, NSD1
anatomical structure development (GO:0048856)	1.58	11	CBFB, KRAS, KIT, CEBPA, DDX41, MLF1, JAK2, FLT3, SH3GL1, RUNX1, GATA2
positive regulation of RNA metabolic process (GO:0051254)	2.51	11	CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	11	CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
cellular biosynthetic process (GO:0044249)	1.37	11	CBFB, CEBPA, NUP214, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
biosynthetic process (GO:0009058)	1.32	11	CBFB, WHSC1L1, NUP214, CEBPA, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, NSD1
macromolecule biosynthetic process (GO:0009059)	1.61	11	CBFB, CEBPA, NUP214, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	11	CBFB, CEBPA, GATA2, PICALM, ETV6, MLLT10, NPM1, TERT, RUNX1, DDX41, NSD1
aromatic compound biosynthetic process (GO:0019438)	1.7	11	CBFB, NUP214, CEBPA, GATA2, ETV6, MLF1, MLLT10, WHSC1L1, TERT, RUNX1, NSD1
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	11	CBFB, NUP214, CEBPA, GATA2, ETV6, MLF1, MLLT10, WHSC1L1, TERT, RUNX1, NSD1
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	11	CBFB, NUP214, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
organic cyclic compound biosynthetic process (GO:1901362)	1.66	11	CBFB, WHSC1L1, NUP214, CEBPA, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, NSD1
heterocycle biosynthetic process (GO:0018130)	1.7	11	CBFB, NUP214, CEBPA, GATA2, ETV6, MLF1, MLLT10, WHSC1L1, TERT, RUNX1, NSD1
cellular macromolecule biosynthetic process (GO:0034645)	1.66	10	CBFB, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
cell differentiation (GO:0030154)	2.14	10	CBFB, KRAS, KIT, CEBPA, GATA2, ETV6, JAK2, MLF1, FLT3, RUNX1
nucleic acid-templated transcription (GO:0097659)	1.91	10	CBFB, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, TERT, RUNX1, WHSC1L1
cellular component organization or biogenesis (GO:0071840)	1.22	10	PICALM, KRAS, KIT, CEBPA, NUP214, JAK2, WHSC1L1, TERT, NPM1, NSD1
cellular component organization (GO:0016043)	1.24	10	PICALM, KRAS, KIT, CEBPA, NUP214, JAK2, WHSC1L1, TERT, NPM1, NSD1
cellular protein metabolic process (GO:0044267)	1.63	9	CBFB, KRAS, KIT, NUP214, TGM6, JAK2, NSD1, FLT3, WHSC1L1
regulation of cellular protein metabolic process (GO:0032268)	1.99	9	PICALM, KRAS, KIT, CEBPA, GATA2, JAK2, NPM1, FLT3, NSD1
negative regulation of metabolic process (GO:0009892)	1.93	9	PICALM, CEBPA, NUP214, GATA2, ETV6, NPM1, TERT, RUNX1, NSD1
regulation of biological quality (GO:0065008)	1.68	9	PICALM, KIT, CEBPA, NUP214, GATA2, FLT3, JAK2, KRAS, TERT
single-multicellular organism process (GO:0044707)	1.78	9	CBFB, KRAS, KIT, CEBPA, DDX41, MLF1, JAK2, RUNX1, GATA2
protein metabolic process (GO:0019538)	1.45	9	CBFB, KRAS, KIT, NUP214, TGM6, JAK2, NSD1, FLT3, WHSC1L1
response to stimulus (GO:0050896)	1.22	9	KRAS, KIT, FLT3, CEBPA, DDX41, JAK2, NPM1, TERT, GATA2
regulation of protein metabolic process (GO:0051246)	1.93	9	PICALM, KRAS, KIT, CEBPA, GATA2, JAK2, NPM1, FLT3, NSD1
cellular protein modification process (GO:0006464)	1.79	9	CBFB, KRAS, KIT, NUP214, TGM6, JAK2, WHSC1L1, FLT3, NSD1
macromolecule modification (GO:0043412)	1.73	9	CBFB, KRAS, KIT, NUP214, TGM6, JAK2, NSD1, FLT3, WHSC1L1
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	9	CBFB, CEBPA, DDX41, ETV6, MLLT10, TERT, RUNX1, GATA2, NSD1
transcription, DNA-templated (GO:0006351)	1.91	9	CBFB, CEBPA, NSD1, GATA2, ETV6, MLLT10, MLF1, RUNX1, WHSC1L1
protein modification process (GO:0036211)	1.79	9	CBFB, KRAS, KIT, NUP214, TGM6, JAK2, NSD1, FLT3, WHSC1L1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	9	PICALM, CEBPA, NUP214, GATA2, ETV6, NPM1, TERT, RUNX1, NSD1
regulation of molecular function (GO:0065009)	1.78	9	PICALM, KRAS, KIT, FLT3, CEBPA, JAK2, NPM1, TERT, NSD1
establishment of localization (GO:0051234)	1.48	9	CHIC2, KIT, NUP214, GATA2, PICALM, JAK2, NPM1, TERT, SH3GL1
localization (GO:0051179)	1.4	9	CHIC2, KIT, NUP214, GATA2, PICALM, JAK2, NPM1, TERT, SH3GL1
multicellular organismal process (GO:0032501)	1.45	9	CBFB, KRAS, KIT, CEBPA, DDX41, MLF1, JAK2, RUNX1, GATA2
regulation of cell proliferation (GO:0042127)	2.41	8	KRAS, KIT, FLT3, CEBPA, GATA2, JAK2, NPM1, TERT
transport (GO:0006810)	1.51	8	CHIC2, KIT, NUP214, GATA2, PICALM, JAK2, NPM1, SH3GL1
regulation of catalytic activity (GO:0050790)	1.97	8	PICALM, KRAS, KIT, FLT3, CEBPA, JAK2, NPM1, TERT
regulation of response to stimulus (GO:0048583)	1.54	8	KRAS, KIT, FLT3, NUP214, GATA2, JAK2, NPM1, TERT
negative regulation of gene expression (GO:0010629)	2.48	8	PICALM, CEBPA, NUP214, GATA2, ETV6, TERT, RUNX1, NSD1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	8	CBFB, CEBPA, DDX41, ETV6, MLLT10, TERT, RUNX1, GATA2
signal transduction (GO:0007165)	1.28	8	KRAS, KIT, CEBPA, JAK2, NPM1, FLT3, SH3GL1, RUNX1
regulation of protein modification process (GO:0031399)	2.32	8	KRAS, KIT, CEBPA, GATA2, JAK2, NPM1, FLT3, NSD1
response to chemical (GO:0042221)	1.98	8	KIT, FLT3, CEBPA, GATA2, JAK2, KRAS, TERT, DDX41
negative regulation of cellular metabolic process (GO:0031324)	2.01	8	PICALM, CEBPA, GATA2, ETV6, NPM1, TERT, RUNX1, NSD1
regulation of phosphorylation (GO:0042325)	2.5	7	KRAS, KIT, CEBPA, JAK2, NPM1, FLT3, NSD1
regulation of phosphorus metabolic process (GO:0051174)	2.35	7	KRAS, KIT, CEBPA, JAK2, NPM1, FLT3, NSD1
cellular response to stimulus (GO:0051716)	1.97	7	KIT, FLT3, CEBPA, DDX41, JAK2, NPM1, TERT
regulation of protein phosphorylation (GO:0001932)	2.57	7	KRAS, KIT, CEBPA, JAK2, NPM1, FLT3, NSD1
regulation of phosphate metabolic process (GO:0019220)	2.35	7	KRAS, KIT, CEBPA, JAK2, NPM1, FLT3, NSD1
positive regulation of molecular function (GO:0044093)	2.23	7	PICALM, KRAS, KIT, TERT, JAK2, NPM1, FLT3
immune system process (GO:0002376)	2.29	7	CBFB, KIT, GATA2, JAK2, KRAS, FLT3, DDX41
positive regulation of multicellular organismal process (GO:0051240)	2.49	7	KIT, CEBPA, DDX41, JAK2, TERT, RUNX1, GATA2
positive regulation of protein metabolic process (GO:0051247)	2.43	7	PICALM, KRAS, KIT, CEBPA, JAK2, NPM1, FLT3
homeostatic process (GO:0042592)	2.61	7	PICALM, FLT3, CEBPA, GATA2, JAK2, KRAS, TERT
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	7	PICALM, KRAS, KIT, CEBPA, JAK2, NPM1, FLT3
regulation of multicellular organismal process (GO:0051239)	1.87	7	KIT, CEBPA, DDX41, JAK2, TERT, RUNX1, GATA2
regulation of cell death (GO:0010941)	2.43	7	PICALM, KRAS, KIT, TERT, JAK2, NPM1, FLT3
response to organic substance (GO:0010033)	2.2	7	KIT, CEBPA, GATA2, JAK2, KRAS, FLT3, DDX41
positive regulation of cell proliferation (GO:0008284)	3.01	6	KIT, TERT, KRAS, JAK2, FLT3, NPM1
organelle organization (GO:0006996)	2.02	6	PICALM, KIT, CEBPA, KRAS, NPM1, TERT
regulation of kinase activity (GO:0043549)	3.07	6	KIT, CEBPA, KRAS, JAK2, FLT3, NPM1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	6	CEBPA, GATA2, ETV6, TERT, RUNX1, NSD1
macromolecular complex subunit organization (GO:0043933)	2.14	6	PICALM, JAK2, WHSC1L1, TERT, NPM1, NSD1
negative regulation of RNA metabolic process (GO:0051253)	2.66	6	CEBPA, GATA2, ETV6, TERT, RUNX1, NSD1
regulation of protein kinase activity (GO:0045859)	3.15	6	KIT, CEBPA, KRAS, JAK2, FLT3, NPM1
regulation of cell differentiation (GO:0045595)	2.42	6	KIT, CEBPA, GATA2, KRAS, JAK2, RUNX1
regulation of transferase activity (GO:0051338)	2.88	6	KIT, CEBPA, KRAS, JAK2, FLT3, NPM1
regulation of signal transduction (GO:0009966)	1.84	6	KIT, TERT, GATA2, KRAS, JAK2, FLT3
regulation of programmed cell death (GO:0043067)	2.49	6	KIT, TERT, KRAS, JAK2, FLT3, NPM1
animal organ development (GO:0048513)	2.53	6	CBFB, KIT, CEBPA, GATA2, FLT3, RUNX1
peptidyl-amino acid modification (GO:0018193)	2.98	6	KIT, NUP214, JAK2, WHSC1L1, FLT3, NSD1
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	6	CEBPA, GATA2, ETV6, TERT, RUNX1, NSD1
regulation of signaling (GO:0023051)	1.72	6	KIT, TERT, GATA2, KRAS, JAK2, FLT3
regulation of localization (GO:0032879)	1.94	6	PICALM, KIT, NUP214, GATA2, JAK2, TERT
regulation of cell communication (GO:0010646)	1.73	6	KIT, TERT, GATA2, KRAS, JAK2, FLT3
positive regulation of catalytic activity (GO:0043085)	2.4	6	PICALM, KIT, TERT, KRAS, JAK2, FLT3
cellular component assembly (GO:0022607)	2.14	5	JAK2, PICALM, KIT, TERT, NPM1
cytokine-mediated signaling pathway (GO:0019221)	3.6	5	JAK2, FLT3, KIT, KRAS, CEBPA
negative regulation of biosynthetic process (GO:0009890)	2.47	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
positive regulation of response to stimulus (GO:0048584)	2.18	5	TERT, FLT3, KIT, JAK2, KRAS
regulation of cellular component organization (GO:0051128)	2.01	5	PICALM, GATA2, KIT, NPM1, NSD1
positive regulation of signaling (GO:0023056)	2.41	5	KRAS, FLT3, KIT, JAK2, TERT
cellular response to chemical stimulus (GO:0070887)	2.57	5	DDX41, FLT3, KIT, TERT, CEBPA
positive regulation of cell communication (GO:0010647)	2.41	5	KRAS, FLT3, KIT, JAK2, TERT
regulation of protein serine/threonine kinase activity (GO:0071900)	3.58	5	KRAS, FLT3, KIT, JAK2, CEBPA
regulation of apoptotic process (GO:0042981)	2.5	5	KRAS, FLT3, TERT, JAK2, NPM1
single-organism metabolic process (GO:0044710)	1.63	5	PICALM, KRAS, KIT, JAK2, CEBPA
positive regulation of signal transduction (GO:0009967)	2.5	5	JAK2, FLT3, KIT, TERT, KRAS
cell surface receptor signaling pathway (GO:0007166)	2.09	5	KRAS, FLT3, KIT, JAK2, CEBPA
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
regulation of immune system process (GO:0002682)	2.5	5	RUNX1, GATA2, KIT, KRAS, JAK2
transcription from RNA polymerase II promoter (GO:0006366)	3.38	5	ETV6, CBFB, RUNX1, GATA2, CEBPA
hematopoietic or lymphoid organ development (GO:0048534)	4.49	5	KIT, CBFB, RUNX1, GATA2, FLT3
cellular localization (GO:0051641)	2.32	5	JAK2, GATA2, KIT, NPM1, NUP214
negative regulation of programmed cell death (GO:0043069)	3.02	5	TERT, KIT, KRAS, JAK2, NPM1
cell proliferation (GO:0008283)	3.23	5	RUNX1, PICALM, KIT, ETV6, FLT3
negative regulation of cell death (GO:0060548)	2.95	5	JAK2, KRAS, KIT, TERT, NPM1
negative regulation of nucleic acid-templated transcription (GO:1903507)	2.71	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
positive regulation of cell differentiation (GO:0045597)	3.01	5	KIT, GATA2, RUNX1, CEBPA, JAK2
single-organism transport (GO:0044765)	2.18	5	PICALM, GATA2, KIT, JAK2, NUP214
negative regulation of transcription, DNA-templated (GO:0045892)	2.75	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
establishment of localization in cell (GO:0051649)	2.47	5	GATA2, KIT, JAK2, NUP214, NPM1
single-organism localization (GO:1902578)	2.09	5	PICALM, GATA2, KIT, JAK2, NUP214
multi-organism process (GO:0051704)	2.65	5	DDX41, KRAS, CEBPA, NUP214, NPM1
negative regulation of RNA biosynthetic process (GO:1902679)	2.7	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
vesicle-mediated transport (GO:0016192)	2.72	5	PICALM, CHIC2, KIT, SH3GL1, GATA2
intracellular transport (GO:0046907)	2.67	5	JAK2, GATA2, KIT, NPM1, NUP214
regulation of response to stress (GO:0080134)	2.53	5	TERT, KRAS, JAK2, NUP214, NPM1
response to stress (GO:0006950)	1.8	5	JAK2, DDX41, KIT, TERT, NPM1
myeloid cell differentiation (GO:0030099)	4.63	5	KIT, CBFB, RUNX1, JAK2, CEBPA
hemopoiesis (GO:0030097)	5.07	5	KIT, CBFB, RUNX1, GATA2, FLT3
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	5	ETV6, GATA2, RUNX1, CEBPA, NSD1
positive regulation of kinase activity (GO:0033674)	3.54	4	KRAS, KIT, FLT3, JAK2
regulation of transport (GO:0051049)	2.24	4	PICALM, GATA2, JAK2, NUP214
cell motility (GO:0048870)	3.02	4	GATA2, KIT, KRAS, JAK2
cell development (GO:0048468)	3.28	4	KIT, GATA2, RUNX1, KRAS
movement of cell or subcellular component (GO:0006928)	2.61	4	GATA2, KIT, KRAS, JAK2
leukocyte activation (GO:0045321)	3.76	4	CBFB, KIT, GATA2, FLT3
regulation of MAP kinase activity (GO:0043405)	3.95	4	KRAS, KIT, FLT3, JAK2
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	4	KRAS, KIT, FLT3, JAK2
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169)	3.54	4	KRAS, KIT, FLT3, JAK2
intracellular signal transduction (GO:0035556)	2.39	4	KRAS, KIT, JAK2, NPM1
developmental maturation (GO:0021700)	4.7	4	PICALM, CBFB, GATA2, CEBPA
regulation of MAPK cascade (GO:0043408)	3.22	4	FLT3, KIT, JAK2, KRAS
interspecies interaction between organisms (GO:0044419)	3.08	4	DDX41, CEBPA, NUP214, NPM1
positive regulation of transferase activity (GO:0051347)	3.31	4	FLT3, KIT, JAK2, KRAS
protein complex subunit organization (GO:0071822)	2.6	4	PICALM, TERT, JAK2, NPM1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122)	3.12	4	ETV6, GATA2, CEBPA, NSD1
chromatin organization (GO:0006325)	3.28	4	WHSC1L1, JAK2, NSD1, NPM1
response to lipid (GO:0033993)	3.11	4	GATA2, KRAS, FLT3, JAK2
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	4	FLT3, KIT, JAK2, KRAS
positive regulation of protein kinase activity (GO:0045860)	3.61	4	FLT3, KIT, JAK2, KRAS
macromolecular complex assembly (GO:0065003)	2.55	4	PICALM, TERT, JAK2, NPM1
cellular response to organic substance (GO:0071310)	2.78	4	DDX41, KIT, FLT3, CEBPA
negative regulation of apoptotic process (GO:0043066)	3.04	4	KRAS, TERT, JAK2, NPM1
negative regulation of molecular function (GO:0044092)	2.74	4	JAK2, PICALM, CEBPA, NPM1
cell migration (GO:0016477)	3.12	4	GATA2, KIT, KRAS, JAK2
negative regulation of cell proliferation (GO:0008285)	3.26	4	JAK2, GATA2, CEBPA, NPM1
protein phosphorylation (GO:0006468)	2.89	4	FLT3, KIT, JAK2, KRAS
positive regulation of phosphate metabolic process (GO:0045937)	2.78	4	FLT3, KIT, JAK2, KRAS
regulation of developmental process (GO:0050793)	2.1	4	KIT, GATA2, RUNX1, TERT
protein complex assembly (GO:0006461)	2.78	4	PICALM, TERT, JAK2, NPM1
phosphorylation (GO:0016310)	2.63	4	FLT3, KIT, JAK2, KRAS
positive regulation of sequence-specific DNA binding transcription factor activity (GO:0051091)	4.29	4	KRAS, KIT, JAK2, NPM1
positive regulation of MAPK cascade (GO:0043410)	3.57	4	FLT3, KIT, JAK2, KRAS
cell activation (GO:0001775)	3.47	4	CBFB, KIT, GATA2, FLT3
multi-organism cellular process (GO:0044764)	3.14	4	DDX41, CEBPA, NUP214, NPM1
locomotion (GO:0040011)	2.91	4	GATA2, KIT, KRAS, JAK2
symbiosis, encompassing mutualism through parasitism (GO:0044403)	3.15	4	DDX41, CEBPA, NUP214, NPM1
positive regulation of intracellular signal transduction (GO:1902533)	2.95	4	KRAS, KIT, FLT3, JAK2
regulation of intracellular signal transduction (GO:1902531)	2.31	4	KRAS, KIT, FLT3, JAK2
leukocyte differentiation (GO:0002521)	4.13	4	CBFB, KIT, FLT3, CEBPA
regulation of hydrolase activity (GO:0051336)	2.53	4	PICALM, KIT, NPM1, JAK2
establishment of protein localization (GO:0045184)	2.53	4	TERT, JAK2, NUP214, NPM1
positive regulation of phosphorylation (GO:0042327)	2.9	4	FLT3, KIT, JAK2, KRAS
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090)	3.83	4	KIT, KRAS, JAK2, NPM1
regulation of cell cycle (GO:0051726)	2.93	4	CEBPA, MLF1, NUP214, NPM1
positive regulation of protein modification process (GO:0031401)	2.7	4	KRAS, KIT, FLT3, JAK2
chemical homeostasis (GO:0048878)	2.97	4	PICALM, GATA2, CEBPA, JAK2
phosphate-containing compound metabolic process (GO:0006796)	2.16	4	FLT3, KIT, JAK2, KRAS
viral process (GO:0016032)	3.15	4	DDX41, CEBPA, NUP214, NPM1
phosphorus metabolic process (GO:0006793)	2.15	4	FLT3, KIT, JAK2, KRAS
single-organism intracellular transport (GO:1902582)	3.59	4	GATA2, KIT, JAK2, NUP214
single-organism cellular localization (GO:1902580)	3.16	4	GATA2, KIT, JAK2, NUP214
positive regulation of protein phosphorylation (GO:0001934)	2.95	4	KRAS, KIT, FLT3, JAK2
nuclear transport (GO:0051169)	4.2	3	JAK2, NPM1, NUP214
protein localization (GO:0008104)	2.36	3	JAK2, NPM1, NUP214
regulation of binding (GO:0051098)	4.08	3	JAK2, TERT, NSD1
regulation of organelle organization (GO:0033043)	2.72	3	GATA2, NPM1, NSD1
embryonic organ development (GO:0048568)	4.86	3	GATA2, KIT, CEBPA
positive regulation of JAK-STAT cascade (GO:0046427)	5.44	3	KIT, FLT3, JAK2
metal ion homeostasis (GO:0055065)	3.61	3	GATA2, PICALM, JAK2
cell maturation (GO:0048469)	4.98	3	CBFB, GATA2, CEBPA
peptidyl-tyrosine phosphorylation (GO:0018108)	4.48	3	KIT, FLT3, JAK2
positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	5.63	3	KIT, FLT3, JAK2
positive regulation of MAP kinase activity (GO:0043406)	4.39	3	KIT, FLT3, KRAS
regulation of vasculature development (GO:1901342)	4.26	3	KIT, GATA2, RUNX1
cell cycle process (GO:0022402)	2.75	3	NUP214, MLF1, NPM1
lymphocyte differentiation (GO:0030098)	4.49	3	CBFB, KIT, FLT3
cellular macromolecular complex assembly (GO:0034622)	3.18	3	PICALM, NPM1, JAK2
inorganic ion homeostasis (GO:0098771)	3.43	3	GATA2, PICALM, JAK2
positive regulation of protein serine/threonine kinase activity (GO:0071902)	4.06	3	KIT, KRAS, FLT3
cell death (GO:0008219)	3.05	3	DDX41, KIT, JAK2
programmed cell death (GO:0012501)	3.1	3	DDX41, KIT, JAK2
multicellular organism development (GO:0007275)	2.54	3	DDX41, CEBPA, MLF1
signal transduction by protein phosphorylation (GO:0023014)	3.79	3	KIT, JAK2, KRAS
regulation of protein localization (GO:0032880)	2.88	3	PICALM, JAK2, TERT
response to endogenous stimulus (GO:0009719)	2.79	3	KIT, KRAS, FLT3
negative regulation of protein metabolic process (GO:0051248)	2.82	3	PICALM, NPM1, CEBPA
positive regulation of vasculature development (GO:1904018)	4.83	3	KIT, GATA2, RUNX1
negative regulation of cell cycle (GO:0045786)	3.67	3	CEBPA, MLF1, NPM1
positive regulation of hydrolase activity (GO:0051345)	2.91	3	PICALM, KIT, JAK2
regulation of cytokine production (GO:0001817)	3.4	3	DDX41, RUNX1, JAK2
intracellular protein transport (GO:0006886)	3.2	3	JAK2, NUP214, NPM1
negative regulation of multicellular organismal process (GO:0051241)	2.84	3	GATA2, RUNX1, JAK2
MAPK cascade (GO:0000165)	3.91	3	KIT, JAK2, KRAS
hematopoietic progenitor cell differentiation (GO:0002244)	5.23	3	KIT, FLT3, MLF1
protein autophosphorylation (GO:0046777)	4.46	3	KIT, FLT3, JAK2
positive regulation of STAT cascade (GO:1904894)	5.44	3	KIT, FLT3, JAK2
positive regulation of immune system process (GO:0002684)	2.96	3	GATA2, RUNX1, KRAS
response to organic cyclic compound (GO:0014070)	3.07	3	KRAS, FLT3, CEBPA
histone modification (GO:0016570)	3.91	3	WHSC1L1, JAK2, NSD1
organic substance transport (GO:0071702)	2.15	3	JAK2, NPM1, NUP214
anatomical structure homeostasis (GO:0060249)	4.25	3	GATA2, KRAS, TERT
myeloid progenitor cell differentiation (GO:0002318)	7.78	3	KIT, FLT3, MLF1
macromolecule localization (GO:0033036)	2.34	3	JAK2, NUP214, NPM1
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	3	KIT, GATA2, RUNX1
ion homeostasis (GO:0050801)	3.42	3	GATA2, PICALM, JAK2
negative regulation of developmental process (GO:0051093)	3.17	3	GATA2, RUNX1, TERT
response to cytokine (GO:0034097)	3.84	3	DDX41, FLT3, JAK2
regulation of JAK-STAT cascade (GO:0046425)	4.78	3	KIT, FLT3, JAK2
establishment of protein localization to organelle (GO:0072594)	3.92	3	JAK2, TERT, NUP214
negative regulation of cell differentiation (GO:0045596)	3.33	3	GATA2, RUNX1, KRAS
nucleocytoplasmic transport (GO:0006913)	4.23	3	JAK2, NUP214, NPM1
defense response (GO:0006952)	2.78	3	DDX41, KIT, JAK2
reproductive process (GO:0022414)	2.55	3	GATA2, KIT, CEBPA
immune effector process (GO:0002252)	3.58	3	DDX41, KIT, GATA2
regulation of immune response (GO:0050776)	2.98	3	KIT, KRAS, JAK2
regulation of proteolysis (GO:0030162)	3.2	3	PICALM, JAK2, CEBPA
positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068)	5.59	3	KIT, FLT3, JAK2
regulation of STAT cascade (GO:1904892)	4.78	3	KIT, FLT3, JAK2
cation homeostasis (GO:0055080)	3.46	3	GATA2, PICALM, JAK2
regulation of neuron death (GO:1901214)	4.19	3	PICALM, KRAS, JAK2
regulation of phosphatidylinositol 3-kinase signaling (GO:0014066)	4.79	3	KIT, FLT3, JAK2
regulation of tyrosine phosphorylation of STAT protein (GO:0042509)	5.49	3	KIT, FLT3, JAK2
response to abiotic stimulus (GO:0009628)	2.8	3	KIT, TERT, KRAS
negative regulation of cellular protein metabolic process (GO:0032269)	2.88	3	PICALM, NPM1, CEBPA
single organism reproductive process (GO:0044702)	2.73	3	GATA2, KIT, CEBPA
endocytosis (GO:0006897)	3.69	3	PICALM, SH3GL1, GATA2
homeostasis of number of cells (GO:0048872)	4.98	3	GATA2, KRAS, FLT3
response to external stimulus (GO:0009605)	2.55	3	DDX41, KIT, JAK2
positive regulation of developmental process (GO:0051094)	2.77	3	KIT, GATA2, RUNX1
peptidyl-lysine modification (GO:0018205)	3.98	3	WHSC1L1, NUP214, NSD1
regulation of peptidyl-tyrosine phosphorylation (GO:0050730)	4.35	3	KIT, FLT3, JAK2
regulation of cellular response to stress (GO:0080135)	3.4	3	TERT, NUP214, NPM1
negative regulation of catalytic activity (GO:0043086)	3.0	3	PICALM, NPM1, CEBPA
peptidyl-tyrosine modification (GO:0018212)	4.47	3	KIT, FLT3, JAK2
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731)	4.62	3	KIT, FLT3, JAK2
single-organism organelle organization (GO:1902589)	2.68	3	PICALM, KIT, KRAS
lymphocyte activation (GO:0046649)	3.96	3	CBFB, KIT, FLT3
regulation of multicellular organismal development (GO:2000026)	2.31	3	KIT, GATA2, RUNX1
cellular response to stress (GO:0033554)	2.51	3	JAK2, TERT, NPM1
response to hormone (GO:0009725)	3.33	3	KIT, KRAS, FLT3
protein transport (GO:0015031)	2.62	3	JAK2, NUP214, NPM1
positive regulation of proteolysis (GO:0045862)	3.86	3	PICALM, JAK2, CEBPA
positive regulation of cytokine production (GO:0001819)	3.82	3	DDX41, RUNX1, JAK2
developmental process involved in reproduction (GO:0003006)	3.36	3	GATA2, KIT, CEBPA
chromatin modification (GO:0016568)	4.06	3	WHSC1L1, JAK2, NSD1
covalent chromatin modification (GO:0016569)	3.89	3	WHSC1L1, JAK2, NSD1
protein methylation (GO:0006479)	4.96	2	WHSC1L1, NSD1
regulation of chromosome organization (GO:0033044)	4.11	2	GATA2, NSD1
negative regulation of transferase activity (GO:0051348)	3.87	2	NPM1, CEBPA
hemostasis (GO:0007599)	4.5	2	GATA2, JAK2
regulation of apoptotic signaling pathway (GO:2001233)	3.83	2	JAK2, TERT
negative regulation of response to stimulus (GO:0048585)	2.52	2	GATA2, TERT
blood coagulation (GO:0007596)	4.52	2	GATA2, JAK2
learning (GO:0007612)	4.85	2	KIT, KRAS
activation of protein kinase activity (GO:0032147)	4.08	2	KIT, JAK2
behavior (GO:0007610)	3.47	2	KIT, KRAS
learning or memory (GO:0007611)	4.33	2	KIT, KRAS
positive regulation of defense response (GO:0031349)	3.83	2	KRAS, JAK2
ossification (GO:0001503)	4.86	2	CBFB, RUNX1
negative regulation of neuron apoptotic process (GO:0043524)	4.82	2	KRAS, JAK2
calcium ion homeostasis (GO:0055074)	3.97	2	GATA2, JAK2
regulation of histone modification (GO:0031056)	4.85	2	GATA2, NSD1
negative regulation of myeloid cell differentiation (GO:0045638)	5.42	2	GATA2, RUNX1
establishment of organelle localization (GO:0051656)	4.15	2	GATA2, KIT
tissue homeostasis (GO:0001894)	4.78	2	GATA2, KRAS
mitochondrion organization (GO:0007005)	3.69	2	TERT, CEBPA
response to external biotic stimulus (GO:0043207)	3.13	2	DDX41, JAK2
cellular macromolecule localization (GO:0070727)	3.1	2	JAK2, NUP214
posttranscriptional regulation of gene expression (GO:0010608)	3.64	2	NPM1, NUP214
cell activation involved in immune response (GO:0002263)	4.86	2	GATA2, KIT
protein modification by small protein conjugation or removal (GO:0070647)	2.95	2	CBFB, NUP214
protein modification by small protein conjugation (GO:0032446)	3.1	2	CBFB, NUP214
positive regulation of lipid metabolic process (GO:0045834)	4.88	2	KIT, FLT3
B cell differentiation (GO:0030183)	5.24	2	KIT, FLT3
negative regulation of immune system process (GO:0002683)	3.85	2	GATA2, RUNX1
cellular homeostasis (GO:0019725)	3.23	2	GATA2, JAK2
positive regulation of transport (GO:0051050)	2.9	2	GATA2, JAK2
erythrocyte differentiation (GO:0030218)	5.88	2	KIT, JAK2
response to corticosteroid (GO:0031960)	4.56	2	KRAS, FLT3
protein import into nucleus (GO:0006606)	5.24	2	JAK2, NUP214
positive regulation of hemopoiesis (GO:1903708)	4.63	2	GATA2, RUNX1
regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)	6.68	2	KIT, JAK2
lymphoid progenitor cell differentiation (GO:0002320)	7.33	2	KIT, FLT3
response to biotic stimulus (GO:0009607)	3.09	2	DDX41, JAK2
regulation of hemopoiesis (GO:1903706)	4.0	2	GATA2, RUNX1
negative regulation of hemopoiesis (GO:1903707)	4.96	2	GATA2, RUNX1
system process (GO:0003008)	2.3	2	KIT, KRAS
positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)	6.9	2	KIT, JAK2
stem cell population maintenance (GO:0019827)	4.83	2	GATA2, KIT
negative regulation of phosphorylation (GO:0042326)	3.7	2	NPM1, CEBPA
organonitrogen compound metabolic process (GO:1901564)	2.32	2	KIT, CEBPA
mast cell activation involved in immune response (GO:0002279)	7.09	2	GATA2, KIT
single-organism behavior (GO:0044708)	3.79	2	KIT, KRAS
myeloid cell activation involved in immune response (GO:0002275)	6.07	2	GATA2, KIT
myeloid leukocyte activation (GO:0002274)	5.15	2	GATA2, KIT
positive regulation of cytosolic calcium ion concentration (GO:0007204)	4.56	2	GATA2, JAK2
positive regulation of oxidoreductase activity (GO:0051353)	5.94	2	KRAS, TERT
regulation of vesicle-mediated transport (GO:0060627)	3.63	2	GATA2, PICALM
regulation of neuron apoptotic process (GO:0043523)	4.47	2	KRAS, JAK2
positive regulation of nitric-oxide synthase activity (GO:0051000)	6.78	2	KRAS, TERT
negative regulation of kinase activity (GO:0033673)	4.22	2	NPM1, CEBPA
visual behavior (GO:0007632)	5.82	2	KIT, KRAS
digestive tract development (GO:0048565)	5.49	2	GATA2, KIT
peptidyl-lysine methylation (GO:0018022)	5.42	2	WHSC1L1, NSD1
lysosome localization (GO:0032418)	6.68	2	GATA2, KIT
regulation of synaptic plasticity (GO:0048167)	4.78	2	KIT, KRAS
regulation of cell migration (GO:0030334)	3.23	2	KIT, JAK2
regulation of long-term neuronal synaptic plasticity (GO:0048169)	6.55	2	KIT, KRAS
regulation of neuronal synaptic plasticity (GO:0048168)	5.84	2	KIT, KRAS
regulation of myeloid leukocyte differentiation (GO:0002761)	5.02	2	GATA2, RUNX1
regulation of oxidoreductase activity (GO:0051341)	5.27	2	KRAS, TERT
negative regulation of myeloid leukocyte differentiation (GO:0002762)	5.9	2	GATA2, RUNX1
immune response-regulating signaling pathway (GO:0002764)	3.72	2	KIT, KRAS
immune response-regulating cell surface receptor signaling pathway (GO:0002768)	3.96	2	KIT, KRAS
exocytosis (GO:0006887)	4.11	2	GATA2, KIT
regulated exocytosis (GO:0045055)	4.44	2	GATA2, KIT
leukocyte activation involved in immune response (GO:0002366)	4.88	2	GATA2, KIT
histone methylation (GO:0016571)	5.3	2	WHSC1L1, NSD1
regulation of defense response (GO:0031347)	3.11	2	KRAS, JAK2
methylation (GO:0032259)	4.06	2	WHSC1L1, NSD1
positive regulation of cellular component organization (GO:0051130)	2.68	2	GATA2, KIT
cellular protein localization (GO:0034613)	3.11	2	JAK2, NUP214
lipid metabolic process (GO:0006629)	2.68	2	KIT, CEBPA
positive regulation of lipid kinase activity (GO:0090218)	6.23	2	KIT, FLT3
positive regulation of protein localization to nucleus (GO:1900182)	4.87	2	JAK2, TERT
regulation of monooxygenase activity (GO:0032768)	5.69	2	KRAS, TERT
tissue development (GO:0009888)	3.27	2	GATA2, JAK2
maintenance of cell number (GO:0098727)	4.82	2	GATA2, KIT
associative learning (GO:0008306)	5.44	2	KIT, KRAS
macromolecule methylation (GO:0043414)	4.42	2	WHSC1L1, NSD1
somatic stem cell population maintenance (GO:0035019)	5.52	2	GATA2, KIT
regulation of phospholipid metabolic process (GO:1903725)	5.69	2	KIT, FLT3
negative regulation of neuron death (GO:1901215)	4.57	2	KRAS, JAK2
gland development (GO:0048732)	4.15	2	GATA2, CEBPA
regulation of phosphatidylinositol 3-kinase activity (GO:0043551)	6.02	2	KIT, FLT3
regulation of protein localization to nucleus (GO:1900180)	4.34	2	JAK2, TERT
secretion (GO:0046903)	3.38	2	GATA2, KIT
positive regulation of phosphatidylinositol 3-kinase activity (GO:0043552)	6.29	2	KIT, FLT3
negative regulation of signal transduction (GO:0009968)	2.75	2	GATA2, TERT
coagulation (GO:0050817)	4.51	2	GATA2, JAK2
cellular response to cytokine stimulus (GO:0071345)	4.33	2	DDX41, FLT3
negative regulation of protein modification process (GO:0031400)	3.4	2	NPM1, CEBPA
regulation of protein stability (GO:0031647)	4.33	2	KRAS, TERT
cognition (GO:0050890)	4.2	2	KIT, KRAS
positive regulation of nervous system development (GO:0051962)	3.64	2	GATA2, KIT
protein localization to nucleus (GO:0034504)	4.9	2	JAK2, NUP214
regulation of nervous system development (GO:0051960)	3.1	2	GATA2, KIT
regulation of cell motility (GO:2000145)	3.16	2	KIT, JAK2
positive regulation of cell motility (GO:2000147)	3.74	2	KIT, JAK2
regulation of myeloid cell differentiation (GO:0045637)	4.56	2	GATA2, RUNX1
positive regulation of cellular amide metabolic process (GO:0034250)	5.0	2	PICALM, NPM1
positive regulation of monooxygenase activity (GO:0032770)	6.47	2	KRAS, TERT
regulation of synapse structure or activity (GO:0050803)	4.77	2	KIT, KRAS
response to radiation (GO:0009314)	3.69	2	KIT, KRAS
negative regulation of cellular component organization (GO:0051129)	3.35	2	PICALM, NPM1
modulation of synaptic transmission (GO:0050804)	4.09	2	KIT, KRAS
regulation of cellular protein localization (GO:1903827)	3.43	2	JAK2, TERT
negative regulation of signaling (GO:0023057)	2.65	2	GATA2, TERT
response to light stimulus (GO:0009416)	4.08	2	KIT, KRAS
negative regulation of cell communication (GO:0010648)	2.66	2	GATA2, TERT
anatomical structure morphogenesis (GO:0009653)	2.53	2	GATA2, KRAS
regulation of GTPase activity (GO:0043087)	3.21	2	KIT, JAK2
visual learning (GO:0008542)	5.92	2	KIT, KRAS
positive regulation of cellular protein localization (GO:1903829)	3.85	2	JAK2, TERT
regulation of neurogenesis (GO:0050767)	3.21	2	GATA2, KIT
positive regulation of phospholipid metabolic process (GO:1903727)	5.99	2	KIT, FLT3
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	2	GATA2, JAK2
cellular protein complex assembly (GO:0043623)	3.9	2	PICALM, JAK2
negative regulation of phosphorus metabolic process (GO:0010563)	3.45	2	NPM1, CEBPA
regeneration (GO:0031099)	4.7	2	FLT3, JAK2
regulation of cell development (GO:0060284)	3.01	2	GATA2, KIT
positive regulation of neurogenesis (GO:0050769)	3.77	2	GATA2, KIT
homeostasis of number of cells within a tissue (GO:0048873)	6.33	2	GATA2, KRAS
histone lysine methylation (GO:0034968)	5.57	2	WHSC1L1, NSD1
biological adhesion (GO:0022610)	2.81	2	LPP, KIT
cellular response to endogenous stimulus (GO:0071495)	3.33	2	KIT, FLT3
positive regulation of cell development (GO:0010720)	3.57	2	GATA2, KIT
regulation of body fluid levels (GO:0050878)	3.76	2	GATA2, JAK2
single-organism nuclear import (GO:1902593)	5.24	2	JAK2, NUP214
cellular metal ion homeostasis (GO:0006875)	3.75	2	GATA2, JAK2
cellular calcium ion homeostasis (GO:0006874)	4.01	2	GATA2, JAK2
protein import (GO:0017038)	4.85	2	JAK2, NUP214
cellular ion homeostasis (GO:0006873)	3.57	2	GATA2, JAK2
regulation of cellular amide metabolic process (GO:0034248)	3.88	2	PICALM, NPM1
regulation of DNA binding (GO:0051101)	5.21	2	JAK2, NSD1
regulation of locomotion (GO:0040012)	3.12	2	KIT, JAK2
mitotic cell cycle process (GO:1903047)	3.12	2	NPM1, NUP214
cellular cation homeostasis (GO:0030003)	3.6	2	GATA2, JAK2
definitive hemopoiesis (GO:0060216)	6.96	2	CBFB, GATA2
cellular chemical homeostasis (GO:0055082)	3.4	2	GATA2, JAK2
embryonic placenta development (GO:0001892)	6.59	2	GATA2, CEBPA
regulation of fat cell differentiation (GO:0045598)	5.04	2	GATA2, CEBPA
positive regulation of NF-kappaB transcription factor activity (GO:0051092)	4.85	2	KRAS, NPM1
aging (GO:0007568)	4.16	2	NPM1, TERT
cell aging (GO:0007569)	5.54	2	NPM1, TERT
cellular response to organic cyclic compound (GO:0071407)	3.93	2	FLT3, CEBPA
positive regulation of binding (GO:0051099)	4.88	2	JAK2, TERT
secretion by cell (GO:0032940)	3.59	2	GATA2, KIT
protein localization to organelle (GO:0033365)	3.57	2	JAK2, NUP214
system development (GO:0048731)	2.92	2	GATA2, SH3GL1
stem cell proliferation (GO:0072089)	6.07	2	RUNX1, ETV6
response to steroid hormone (GO:0048545)	4.24	2	KRAS, FLT3
regulation of chromatin organization (GO:1902275)	4.69	2	GATA2, NSD1
response to glucocorticoid (GO:0051384)	4.63	2	KRAS, FLT3
regulation of cellular localization (GO:0060341)	3.03	2	JAK2, TERT
cell projection organization (GO:0030030)	3.14	2	KIT, JAK2
B cell activation (GO:0042113)	4.84	2	KIT, FLT3
actin cytoskeleton organization (GO:0030036)	4.1	2	KIT, KRAS
protein alkylation (GO:0008213)	4.96	2	WHSC1L1, NSD1
leukocyte migration (GO:0050900)	4.19	2	KIT, KRAS
Fc receptor signaling pathway (GO:0038093)	4.45	2	KIT, KRAS
positive regulation of cell death (GO:0010942)	3.32	2	PICALM, JAK2
regulation of lipid kinase activity (GO:0043550)	5.84	2	KIT, FLT3
divalent inorganic cation homeostasis (GO:0072507)	3.9	2	GATA2, JAK2
mast cell degranulation (GO:0043303)	7.09	2	GATA2, KIT
regulation of cellular component biogenesis (GO:0044087)	3.08	2	KIT, NPM1
regulation of tyrosine phosphorylation of Stat3 protein (GO:0042516)	5.94	2	KIT, JAK2
positive regulation of tyrosine phosphorylation of Stat3 protein (GO:0042517)	6.12	2	KIT, JAK2
positive regulation of angiogenesis (GO:0045766)	4.93	2	GATA2, RUNX1
myeloid leukocyte differentiation (GO:0002573)	5.23	2	KIT, CEBPA
leukocyte proliferation (GO:0070661)	5.25	2	KIT, FLT3
positive regulation of myeloid cell differentiation (GO:0045639)	5.33	2	GATA2, RUNX1
negative regulation of phosphate metabolic process (GO:0045936)	3.45	2	NPM1, CEBPA
neurological system process (GO:0050877)	2.64	2	KIT, KRAS
regulation of angiogenesis (GO:0045765)	4.36	2	GATA2, RUNX1
neuron development (GO:0048666)	4.8	2	GATA2, RUNX1
positive regulation of cell migration (GO:0030335)	3.77	2	KIT, JAK2
negative regulation of protein kinase activity (GO:0006469)	4.29	2	NPM1, CEBPA
regulation of innate immune response (GO:0045088)	3.86	2	KRAS, JAK2
actin filament-based process (GO:0030029)	3.94	2	KIT, KRAS
regulation of lipid metabolic process (GO:0019216)	4.08	2	KIT, FLT3
regulation of endopeptidase activity (GO:0052548)	3.8	2	PICALM, JAK2
apoptotic process (GO:0006915)	3.14	2	DDX41, JAK2
nuclear import (GO:0051170)	5.06	2	JAK2, NUP214
regulation of Notch signaling pathway (GO:0008593)	5.51	2	GATA2, KIT
cell adhesion (GO:0007155)	2.82	2	LPP, KIT
tube development (GO:0035295)	4.41	2	GATA2, KIT
positive regulation of peptidase activity (GO:0010952)	4.7	2	PICALM, JAK2
regulation of endocytosis (GO:0030100)	4.42	2	GATA2, PICALM
organelle localization (GO:0051640)	3.94	2	GATA2, KIT
positive regulation of GTPase activity (GO:0043547)	3.28	2	KIT, JAK2
regulation of nitric-oxide synthase activity (GO:0050999)	5.9	2	KRAS, TERT
positive regulation of cellular component movement (GO:0051272)	3.71	2	KIT, JAK2
regulation of cellular component movement (GO:0051270)	3.08	2	KIT, JAK2
cytoskeleton organization (GO:0007010)	3.22	2	KIT, KRAS
hematopoietic stem cell proliferation (GO:0071425)	7.16	2	RUNX1, ETV6
positive regulation of locomotion (GO:0040017)	3.71	2	KIT, JAK2
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	2	GATA2, JAK2
cellular response to hormone stimulus (GO:0032870)	3.99	2	KIT, FLT3
negative regulation of leukocyte differentiation (GO:1902106)	5.3	2	GATA2, RUNX1
regulation of leukocyte differentiation (GO:1902105)	4.26	2	GATA2, RUNX1
leukocyte degranulation (GO:0043299)	6.4	2	GATA2, KIT
regulation of peptidase activity (GO:0052547)	3.75	2	PICALM, JAK2
DNA metabolic process (GO:0006259)	3.09	2	NPM1, TERT
negative regulation of protein phosphorylation (GO:0001933)	3.79	2	NPM1, CEBPA
RNA processing (GO:0006396)	3.01	2	DDX41, TERT
mast cell activation (GO:0045576)	6.73	2	GATA2, KIT

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
response to erythropoietin (GO:0036017)	NEW	8.63	0.044	KIT, JAK2
cytokine-mediated signaling pathway (GO:0019221)	-	3.6	0.007	KIT, CEBPA, NUP214, KRAS, JAK2, FLT3
positive regulation of cellular biosynthetic process (GO:0031328)	-	2.3	0.0	CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, RUNX1, GATA2, NSD1
regulation of cellular biosynthetic process (GO:0031326)	-	1.38	0.036	CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, RUNX1, GATA2, WHSC1L1
positive regulation of cellular metabolic process (GO:0031325)	-	1.81	0.0	CBFB, KRAS, KIT, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, FLT3, NPM1, RUNX1, DDX41, NSD1
positive regulation of nitrogen compound metabolic process (GO:0051173)	-	2.29	0.002	CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, JAK2, RUNX1, GATA2, NSD1
cell maturation (GO:0048469)	-	4.98	0.017	CBFB, CEBPA, GATA2, KRAS, JAK2, RUNX1
negative regulation of gene expression (GO:0010629)	-	2.48	0.023	PICALM, KRAS, CEBPA, NUP214, NSD1, GATA2, FLT3, ETV6, JAK2, TERT, NPM1, RUNX1, WHSC1L1
positive regulation of gene expression (GO:0010628)	-	2.35	0.0	CBFB, KIT, CEBPA, DDX41, PICALM, ETV6, MLLT10, KRAS, RUNX1, GATA2, NSD1
negative regulation of myeloid cell differentiation (GO:0045638)	-	5.42	0.014	GATA2, FLT3, RUNX1, JAK2, NSD1
regulation of protein serine/threonine kinase activity (GO:0071900)	-	3.58	0.03	KRAS, KIT, FLT3, GATA2, JAK2, ETV6, TERT, NPM1, RUNX1
developmental maturation (GO:0021700)	-	4.7	0.032	CBFB, CEBPA, GATA2, PICALM, JAK2, KRAS, RUNX1
positive regulation of metabolic process (GO:0009893)	-	1.74	0.0	CBFB, KRAS, KIT, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, FLT3, NPM1, RUNX1, DDX41, NSD1
positive regulation of RNA biosynthetic process (GO:1902680)	-	2.54	0.006	CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, RUNX1, GATA2, NSD1
positive regulation of macromolecule metabolic process (GO:0010604)	-	1.81	0.0	CBFB, KRAS, KIT, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, FLT3, NPM1, RUNX1, DDX41, NSD1
cellular macromolecule metabolic process (GO:0044260)	-	0.93	0.013	CBFB, WHSC1L1, NUP214, CEBPA, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, KIT, RUNX1, TGM6, GATA2
cellular developmental process (GO:0048869)	-	1.82	0.028	CBFB, KRAS, KIT, CEBPA, GATA2, PICALM, ETV6, JAK2, MLF1, FLT3, RUNX1
positive regulation of biosynthetic process (GO:0009891)	-	2.29	0.0	CBFB, CEBPA, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, NSD1
regulation of cellular macromolecule biosynthetic process (GO:2000112)	-	1.46	0.016	CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of tyrosine phosphorylation of STAT protein (GO:0042531)	-	5.63	0.013	KIT, RUNX1, FLT3, JAK2
myeloid leukocyte differentiation (GO:0002573)	-	5.23	0.01	KIT, GATA2, RUNX1, CEBPA, JAK2
hematopoietic progenitor cell differentiation (GO:0002244)	-	5.23	0.004	KIT, FLT3, JAK2, MLF1, TERT, RUNX1
positive regulation of myeloid cell differentiation (GO:0045639)	-	5.33	0.009	KIT, GATA2, RUNX1, KRAS, JAK2
positive regulation of transcription, DNA-templated (GO:0045893)	-	2.56	0.004	CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, RUNX1, GATA2, NSD1
embryonic organ development (GO:0048568)	-	4.86	0.015	KIT, CEBPA, GATA2, JAK2, FLT3, RUNX1
lymphoid progenitor cell differentiation (GO:0002320)	-	7.33	0.008	KIT, FLT3, JAK2
hematopoietic or lymphoid organ development (GO:0048534)	-	4.49	0.0	CBFB, KRAS, KIT, GATA2, PICALM, JAK2, NPM1, FLT3, RUNX1
regulation of gene expression (GO:0010468)	-	1.37	0.049	CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, WHSC1L1
developmental process (GO:0032502)	-	1.36	0.003	CBFB, KRAS, KIT, FLT3, CEBPA, DDX41, PICALM, ETV6, JAK2, MLF1, TERT, NPM1, SH3GL1, RUNX1, GATA2, NSD1
cell differentiation (GO:0030154)	-	2.14	0.008	CBFB, KRAS, KIT, CEBPA, GATA2, ETV6, JAK2, MLF1, FLT3, RUNX1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	-	2.35	0.017	CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, RUNX1, GATA2, NSD1
response to cytokine (GO:0034097)	-	3.84	0.007	KIT, CEBPA, NUP214, DDX41, JAK2, KRAS, FLT3
regulation of biosynthetic process (GO:0009889)	-	1.37	0.04	CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, WHSC1L1
single-organism developmental process (GO:0044767)	-	1.49	0.006	CBFB, KRAS, KIT, FLT3, CEBPA, GATA2, PICALM, ETV6, JAK2, MLF1, TERT, NPM1, RUNX1, DDX41, NSD1
regulation of osteoblast differentiation (GO:0045667)	NEW	4.99	0.003	CEBPA, GATA2, JAK2, LPP, NPM1, RUNX1
lymphocyte activation (GO:0046649)	-	3.96	0.039	CBFB, KRAS, KIT, GATA2, JAK2, NPM1, FLT3, RUNX1
positive regulation of phosphatidylinositol 3-kinase signaling (GO:0014068)	-	5.59	0.032	KIT, FLT3, JAK2
definitive hemopoiesis (GO:0060216)	-	6.96	0.001	CBFB, RUNX1, GATA2
myeloid progenitor cell differentiation (GO:0002318)	-	7.78	0.0	KIT, RUNX1, FLT3, MLF1
leukocyte differentiation (GO:0002521)	-	4.13	0.007	CBFB, KIT, CEBPA, GATA2, JAK2, KRAS, FLT3, RUNX1
regulation of tyrosine phosphorylation of STAT protein (GO:0042509)	-	5.49	0.029	KIT, RUNX1, FLT3, JAK2
regulation of RNA biosynthetic process (GO:2001141)	-	1.55	0.007	CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, RUNX1, GATA2, WHSC1L1
negative regulation of phosphorylation (GO:0042326)	-	3.7	0.035	KRAS, KIT, FLT3, GATA2, JAK2, NPM1, TERT, RUNX1
cellular response to erythropoietin (GO:0036018)	NEW	8.63	0.044	KIT, JAK2
cellular response to cytokine stimulus (GO:0071345)	-	4.33	0.002	KIT, CEBPA, NUP214, DDX41, JAK2, KRAS, FLT3
positive regulation of JAK-STAT cascade (GO:0046427)	-	5.44	0.042	KIT, RUNX1, FLT3, JAK2
regulation of RNA metabolic process (GO:0051252)	-	1.52	0.009	CBFB, KRAS, KIT, CEBPA, NSD1, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, RUNX1, GATA2, WHSC1L1
positive regulation of RNA metabolic process (GO:0051254)	-	2.51	0.006	CBFB, CEBPA, DDX41, PICALM, ETV6, MLLT10, RUNX1, GATA2, NSD1
cytokine production (GO:0001816)	NEW	5.42	0.006	KIT, GATA2, RUNX1, KRAS, JAK2
regulation of transcription, DNA-templated (GO:0006355)	-	1.56	0.006	CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of macromolecule biosynthetic process (GO:0010557)	-	2.39	0.0	CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, RUNX1, GATA2, NSD1
regulation of macromolecule biosynthetic process (GO:0010556)	-	1.43	0.023	CBFB, KRAS, KIT, CEBPA, NSD1, GATA2, PICALM, ETV6, MLLT10, JAK2, NPM1, RUNX1, DDX41, WHSC1L1
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	-	2.81	0.049	CBFB, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, FLT3, RUNX1, GATA2, NSD1
lymphocyte differentiation (GO:0030098)	-	4.49	0.008	CBFB, KIT, GATA2, JAK2, KRAS, FLT3, RUNX1
myeloid cell differentiation (GO:0030099)	-	4.63	0.001	CBFB, KIT, CEBPA, GATA2, JAK2, ETV6, RUNX1
hemopoiesis (GO:0030097)	-	5.07	0.0	CBFB, KIT, GATA2, PICALM, JAK2, FLT3, RUNX1
regulation of myeloid cell differentiation (GO:0045637)	-	4.56	0.005	KIT, GATA2, JAK2, KRAS, FLT3, RUNX1, NSD1
positive regulation of cellular process (GO:0048522)	-	1.3	0.017	CBFB, KRAS, KIT, CEBPA, DDX41, PICALM, ETV6, JAK2, MLLT10, NPM1, FLT3, RUNX1, GATA2, NSD1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	23	CHIC2, NUP214, GATA2, CBFB, JAK2, LPP, MLF1, RUNX1, CEBPA, TGM6, KRAS, MLLT10, KIT, FLT3, DDX41, NPM1, SETBP1, WHSC1L1, PICALM, ETV6, TERT, SH3GL1, NSD1
cell part (GO:0044464)	0.11	23	CBFB, NUP214, GATA2, CHIC2, JAK2, LPP, NPM1, RUNX1, CEBPA, TGM6, KRAS, MLLT10, KIT, FLT3, DDX41, SETBP1, WHSC1L1, PICALM, MLF1, ETV6, TERT, SH3GL1, NSD1
intracellular organelle (GO:0043229)	0.51	22	CBFB, NUP214, GATA2, CHIC2, JAK2, LPP, NPM1, RUNX1, CEBPA, KRAS, MLLT10, KIT, FLT3, DDX41, SETBP1, WHSC1L1, PICALM, MLF1, ETV6, TERT, SH3GL1, NSD1
membrane-bounded organelle (GO:0043227)	0.47	22	CBFB, NUP214, GATA2, CHIC2, JAK2, LPP, NPM1, RUNX1, CEBPA, KRAS, MLLT10, KIT, FLT3, DDX41, SETBP1, WHSC1L1, PICALM, MLF1, ETV6, TERT, SH3GL1, NSD1
intracellular membrane-bounded organelle (GO:0043231)	0.6	22	CHIC2, NUP214, GATA2, CBFB, JAK2, LPP, MLF1, RUNX1, CEBPA, KRAS, MLLT10, KIT, FLT3, DDX41, NPM1, SETBP1, WHSC1L1, PICALM, ETV6, TERT, SH3GL1, NSD1
organelle (GO:0043226)	0.4	22	CBFB, NUP214, GATA2, CHIC2, JAK2, LPP, NPM1, RUNX1, CEBPA, KRAS, MLLT10, KIT, FLT3, DDX41, SETBP1, WHSC1L1, PICALM, MLF1, ETV6, TERT, SH3GL1, NSD1
nucleus (GO:0005634)	1.07	18	CBFB, NUP214, CEBPA, NSD1, DDX41, FLT3, ETV6, LPP, JAK2, MLLT10, MLF1, TERT, NPM1, PICALM, SETBP1, RUNX1, GATA2, WHSC1L1
intracellular organelle part (GO:0044446)	0.81	16	CHIC2, NUP214, CEBPA, NSD1, DDX41, FLT3, ETV6, JAK2, MLLT10, NPM1, TERT, PICALM, SH3GL1, RUNX1, GATA2, WHSC1L1
organelle part (GO:0044422)	0.79	16	CHIC2, NUP214, CEBPA, NSD1, GATA2, FLT3, ETV6, MLLT10, JAK2, TERT, NPM1, PICALM, SH3GL1, RUNX1, DDX41, WHSC1L1
cytoplasm (GO:0005737)	1.01	13	KRAS, KIT, FLT3, TGM6, ETV6, LPP, JAK2, MLLT10, MLF1, TERT, NPM1, SH3GL1, RUNX1
cytoplasmic part (GO:0044444)	0.82	12	CHIC2, KRAS, KIT, FLT3, NUP214, DDX41, PICALM, JAK2, NPM1, TERT, SH3GL1, GATA2
membrane (GO:0016020)	0.68	12	CHIC2, KRAS, KIT, DDX41, CBFB, ETV6, LPP, JAK2, FLT3, NPM1, PICALM, SH3GL1
nuclear part (GO:0044428)	1.55	12	WHSC1L1, NUP214, CEBPA, DDX41, ETV6, JAK2, MLLT10, NPM1, TERT, RUNX1, GATA2, NSD1
nucleoplasm (GO:0005654)	1.89	9	NUP214, GATA2, JAK2, MLLT10, NSD1, TERT, NPM1, RUNX1, WHSC1L1
macromolecular complex (GO:0032991)	1.35	9	PICALM, CEBPA, NUP214, DDX41, FLT3, NPM1, TERT, SH3GL1, GATA2
non-membrane-bounded organelle (GO:0043228)	1.76	8	CEBPA, JAK2, ETV6, WHSC1L1, TERT, NPM1, SH3GL1, NSD1
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	8	CEBPA, JAK2, ETV6, WHSC1L1, TERT, NPM1, SH3GL1, NSD1
protein complex (GO:0043234)	1.51	7	PICALM, TERT, NUP214, GATA2, FLT3, SH3GL1, CEBPA
membrane part (GO:0044425)	0.95	7	PICALM, KRAS, KIT, JAK2, ETV6, FLT3, RUNX1
cytosol (GO:0005829)	1.68	7	KRAS, NUP214, GATA2, JAK2, NPM1, FLT3, DDX41
cell junction (GO:0030054)	2.75	6	KIT, NUP214, KRAS, LPP, NPM1, SH3GL1
plasma membrane part (GO:0044459)	1.95	5	PICALM, KRAS, KIT, FLT3, JAK2
plasma membrane (GO:0005886)	1.39	5	LPP, CHIC2, KIT, FLT3, KRAS
nucleolus (GO:0005730)	3.06	4	ETV6, TERT, CEBPA, NPM1
integral component of membrane (GO:0016021)	1.14	4	KIT, RUNX1, FLT3, ETV6
anchoring junction (GO:0070161)	3.61	4	LPP, KRAS, NPM1, NUP214
adherens junction (GO:0005912)	3.66	4	LPP, KRAS, NPM1, NUP214
cell-substrate adherens junction (GO:0005924)	3.83	4	LPP, KRAS, NPM1, NUP214
focal adhesion (GO:0005925)	3.83	4	LPP, KRAS, NUP214, NPM1
intrinsic component of membrane (GO:0031224)	1.13	4	KIT, RUNX1, FLT3, ETV6
cell-substrate junction (GO:0030055)	3.82	4	LPP, KRAS, NUP214, NPM1
vesicle (GO:0031982)	1.64	3	CHIC2, KIT, PICALM
vacuole (GO:0005773)	2.92	3	SH3GL1, KIT, GATA2
cytoplasmic vesicle (GO:0031410)	2.87	3	CHIC2, KIT, PICALM
membrane region (GO:0098589)	3.95	3	PICALM, KRAS, JAK2
ribonucleoprotein complex (GO:1990904)	3.19	3	DDX41, NPM1, TERT
membrane-bounded vesicle (GO:0031988)	1.71	3	CHIC2, KIT, PICALM
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	3	CHIC2, KIT, PICALM
intracellular vesicle (GO:0097708)	2.86	3	CHIC2, KIT, PICALM
intracellular ribonucleoprotein complex (GO:0030529)	3.19	3	DDX41, NPM1, TERT
chromosome (GO:0005694)	3.78	3	WHSC1L1, TERT, NSD1
cytoskeleton (GO:0005856)	2.55	2	JAK2, NPM1
plasma membrane region (GO:0098590)	2.97	2	PICALM, JAK2
endosomal part (GO:0044440)	3.73	2	SH3GL1, JAK2
lytic vacuole (GO:0000323)	3.89	2	GATA2, KIT
endoplasmic reticulum (GO:0005783)	2.56	2	DDX41, FLT3
Golgi apparatus (GO:0005794)	2.7	2	CHIC2, PICALM
organelle lumen (GO:0043233)	3.05	2	FLT3, JAK2
mast cell granule (GO:0042629)	6.76	2	GATA2, KIT
membrane-enclosed lumen (GO:0031974)	3.05	2	FLT3, JAK2
extrinsic component of membrane (GO:0019898)	4.51	2	KRAS, JAK2
lysosome (GO:0005764)	3.89	2	GATA2, KIT
intracellular organelle lumen (GO:0070013)	3.05	2	FLT3, JAK2
cytoskeletal part (GO:0044430)	2.49	2	SH3GL1, NPM1
vacuolar part (GO:0044437)	3.26	2	SH3GL1, JAK2
mitochondrion (GO:0005739)	2.42	2	KRAS, TERT
transcription factor complex (GO:0005667)	4.1	2	GATA2, CEBPA
membrane microdomain (GO:0098857)	4.17	2	KRAS, JAK2
extrinsic component of cytoplasmic side of plasma membrane (GO:0031234)	5.63	2	KRAS, JAK2
extrinsic component of plasma membrane (GO:0019897)	5.25	2	KRAS, JAK2
membrane raft (GO:0045121)	4.18	2	KRAS, JAK2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
external side of plasma membrane (GO:0009897)	NEW	4.46	0.021	KIT, NUP214, KRAS, JAK2, FLT3, RUNX1
intracellular organelle (GO:0043229)	-	0.51	0.004	SETBP1, CHIC2, KRAS, KIT, NUP214, CEBPA, DDX41, CBFB, ETV6, LPP, JAK2, MLLT10, WHSC1L1, MLF1, TERT, NPM1, PICALM, SH3GL1, RUNX1, GATA2, NSD1
nuclear part (GO:0044428)	-	1.55	0.014	KRAS, KIT, NUP214, CEBPA, NSD1, DDX41, ETV6, LPP, JAK2, MLLT10, NPM1, TERT, SETBP1, RUNX1, GATA2, WHSC1L1
intracellular membrane-bounded organelle (GO:0043231)	-	0.6	0.025	CHIC2, KRAS, KIT, NUP214, CEBPA, NSD1, DDX41, CBFB, ETV6, LPP, JAK2, MLLT10, MLF1, NPM1, PICALM, SETBP1, RUNX1, GATA2, WHSC1L1