Disease table of LYMPHOMA, NON-HODGKIN, FAMILIAL OMIM ID: 605027

Gene-disease associations table

GeneAssociated with LYMPHOMA, NON-HODGKIN, FAMILIAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
TP53ClinVarHGNC link17p13.112114550, 260500, 605027, PS137800, 614740, 114480, 260350, 607107, 202300, 114500, PS151623, 259500
RAD54BClinVar, OMIMHGNC link8q22.12114500, 605027
RAD54LClinVar, OMIMHGNC link1p34.12605027, 114480
CASP10ClinVar, OMIM, HUMSAVARHGNC link2q33.13603909, 613659, 605027
PRF1ClinVar, OMIMHGNC link10q22.13609135, 605027, 603553
BCL10OMIMHGNC link1p22.35273300, 156240, 137245, 605027, 616098
BRAFClinVar, HUMSAVARHGNC link7q348605027, PS115150, PS151100, PS155600, 211980, PS188550, PS163950, 114500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1p2BCL10, RAD54L
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
12BCL10, RAD54L
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
TP53YES159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING11TP53
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
TP53YES50ATM, RELA, ERCC2, ETS2, ELF4, EZH2, HDAC9, FOS, PAX5, MCM4, RUVBL1, ZBTB2, EGR1, KLF4, MCM2, AATF, PAX2, TFDP1, STAT1, IRF1, PAX8, HIPK2, HDAC1, SIRT1, MDM4, VHL, ESR1, ING1, IFI16, STAT3, JUN, TP53, ABL1, NUPR1, NFKB1, E2F1, ETS1, CREBBP, HOXA10, NR3C1, YY1, NF1, ING4, HMGA1, SOX6, BDP1, MYC, PPARG, PML, MYCN1TP53
PRF1YES1STAT40
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
TP53RAD54BNo9SUMO1, CSNK1E, HECW2, MDM2, MDM4, PLCG2, UBE2I, WRN, RAD51
TP53RAD54LNo1HECW2
TP53CASP10No6RYBP, CASP8, MAPK8, RNF34, RB1, CFLAR
TP53BCL10No10ATM, IKBKB, MAPK9, UBE2N, SRSF1, ELAVL1, CSNK1A1, BTRC, NFKBIA, CHUK
TP53BRAFNo14HSPA9, HSPA8, HSP90AB1, PHKB, MAPK1, HRAS, IQGAP1, MAPK3, HSPA1A, HSP90AA1, YWHAE, SFN, HSPA5, YWHAZ
RAD54BRAD54LNo1HECW2
RAD54LBRAFNo1LIMK1
CASP10BCL10No5TNFRSF1A, TNFRSF10A, BIRC2, XIAP, BIRC3
BCL10BRAFNo1AKT1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
TP53RAD54BNo-4UBE2I, RAD51, BLM, WRN
TP53RAD54LNo-3BLM, RAD51, WRN
TP53BCL10No-11BIRC5, RELA, NFKB1, UBE2N, STAT5A, TRAF6, CSNK1A1, IKBKB, AKT1, UBC, GTSE1
TP53BRAFNo-17AKT1, MCL1, PRKCD, MAPK1, HRAS, MAPK3, HSP90AA1, UBC, YWHAE, RAF1, YWHAG, KRAS, SFN, PPP2R1A, PIN1, MAP3K1, YWHAZ
RAD54BRAD54LNo-12FEN1, WRN, MUS81, DMC1, FANCM, BLM, RAD51D, XRCC3, RAD51C, RAD51B, RECQL, RAD51
BCL10BRAFNo-3UBC, AKT1, PRKCQ

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
CASP10BCL10No-2FADD, CASP8

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Melanomahsa052186.562BRAF, TP53
Bladder cancerhsa052197.382BRAF, TP53
Homologous recombinationhsa034407.912RAD54L, RAD54B
Pancreatic cancerhsa052126.562BRAF, TP53
Endometrial cancerhsa052136.812BRAF, TP53
Colorectal cancerhsa052106.522BRAF, TP53
Chronic myeloid leukemiahsa052206.482BRAF, TP53
Thyroid cancerhsa052167.482BRAF, TP53
Pathways in cancerhsa052003.982BRAF, TP53
Gliomahsa052146.662BRAF, TP53
Prostate cancerhsa052156.112BRAF, TP53
Tuberculosishsa051525.172BCL10, CASP10
Proteoglycans in cancerhsa052055.022BRAF, TP53
Neurotrophin signaling pathwayhsa047225.782BRAF, TP53
Non-small cell lung cancerhsa052236.882BRAF, TP53
MAPK signaling pathwayhsa040104.632BRAF, TP53
Natural killer cell mediated cytotoxicityhsa046505.532BRAF, PRF1
Apoptosishsa042106.232TP53, CASP10
Hepatitis Chsa051605.682BRAF, TP53
Hepatitis Bhsa051615.522TP53, CASP10

NET-GE enrichment

Term New enriched termICP valueGenes
Apoptosis (hsa04210) -6.230.029BCL10, TP53, CASP10
Homologous recombination (hsa03440) -7.910.03RAD54L, RAD54B
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Innate Immune SystemR-HSA-1682493.173BRAF, BCL10, CASP10
Immune SystemR-HSA-1682562.373BRAF, BCL10, CASP10
Signal TransductionR-HSA-1625821.783BRAF, TP53, CASP10
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032BRAF, BCL10
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.187CASP10, BRAF, TP53, RAD54B, PRF1, RAD54L, BCL10
protein binding (GO:0005515) 0.466CASP10, BRAF, PRF1, TP53, RAD54L, BCL10
enzyme binding (GO:0019899) 2.274BRAF, BCL10, TP53, CASP10
ribonucleotide binding (GO:0032553) 2.194RAD54B, RAD54L, BRAF, TP53
carbohydrate derivative binding (GO:0097367) 2.034RAD54B, RAD54L, BRAF, TP53
organic cyclic compound binding (GO:0097159) 1.054RAD54B, RAD54L, BRAF, TP53
adenyl nucleotide binding (GO:0030554) 2.44RAD54B, RAD54L, BRAF, TP53
purine ribonucleoside triphosphate binding (GO:0035639) 2.224RAD54B, RAD54L, BRAF, TP53
nucleotide binding (GO:0000166) 1.964RAD54B, RAD54L, BRAF, TP53
small molecule binding (GO:0036094) 1.894RAD54B, RAD54L, BRAF, TP53
catalytic activity (GO:0003824) 1.054RAD54B, RAD54L, BRAF, CASP10
purine ribonucleoside binding (GO:0032550) 2.224RAD54B, RAD54L, BRAF, TP53
adenyl ribonucleotide binding (GO:0032559) 2.414RAD54B, RAD54L, BRAF, TP53
ATP binding (GO:0005524) 2.434RAD54B, RAD54L, BRAF, TP53
purine nucleoside binding (GO:0001883) 2.224RAD54B, RAD54L, BRAF, TP53
ribonucleoside binding (GO:0032549) 2.224RAD54B, RAD54L, BRAF, TP53
purine ribonucleotide binding (GO:0032555) 2.24RAD54B, RAD54L, BRAF, TP53
purine nucleotide binding (GO:0017076) 2.194RAD54B, RAD54L, BRAF, TP53
heterocyclic compound binding (GO:1901363) 1.064RAD54B, RAD54L, BRAF, TP53
nucleoside phosphate binding (GO:1901265) 1.964RAD54B, RAD54L, BRAF, TP53
nucleoside binding (GO:0001882) 2.214RAD54B, RAD54L, BRAF, TP53
hydrolase activity (GO:0016787) 1.93RAD54L, RAD54B, CASP10
ubiquitin protein ligase binding (GO:0031625) 4.173BCL10, TP53, CASP10
ubiquitin-like protein ligase binding (GO:0044389) 4.153BCL10, TP53, CASP10
cation binding (GO:0043169) 1.43BRAF, PRF1, TP53
ion binding (GO:0043167) 1.363BRAF, PRF1, TP53
protein kinase binding (GO:0019901) 3.443BRAF, BCL10, TP53
kinase binding (GO:0019900) 3.323BRAF, BCL10, TP53
nucleic acid binding (GO:0003676) 1.443RAD54L, RAD54B, TP53
DNA binding (GO:0003677) 1.923RAD54L, RAD54B, TP53
metal ion binding (GO:0046872) 1.413BRAF, PRF1, TP53
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032RAD54L, RAD54B
signal transducer activity (GO:0004871) 2.282BRAF, CASP10
protein self-association (GO:0043621) 5.932BCL10, TP53
transcription factor binding (GO:0008134) 3.462BCL10, TP53
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032RAD54L, RAD54B
helicase activity (GO:0004386) 4.692RAD54L, RAD54B
pyrophosphatase activity (GO:0016462) 3.042RAD54L, RAD54B
calcium ion binding (GO:0005509) 3.172BRAF, PRF1
protease binding (GO:0002020) 5.082BCL10, TP53
nucleoside-triphosphatase activity (GO:0017111) 3.092RAD54L, RAD54B
protein dimerization activity (GO:0046983) 2.722BRAF, TP53
protein heterodimerization activity (GO:0046982) 3.642BRAF, TP53
identical protein binding (GO:0042802) 2.632BRAF, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
ubiquitin protein ligase binding (GO:0031625) -4.170.004BCL10, TP53, CASP10
small conjugating protein ligase binding (GO:0044389) -4.150.004BCL10, TP53, CASP10
protease binding (GO:0002020) -5.080.044BCL10, TP53
mitogen-activated protein kinase kinase binding (GO:0031434) NEW6.970.013BRAF, TP53
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.267CASP10, BRAF, TP53, RAD54B, PRF1, RAD54L, BCL10
single-organism process (GO:0044699) 0.487CASP10, BRAF, TP53, RAD54B, PRF1, RAD54L, BCL10
primary metabolic process (GO:0044238) 0.696CASP10, BRAF, TP53, RAD54B, RAD54L, BCL10
response to stimulus (GO:0050896) 1.226BRAF, PRF1, RAD54B, TP53, RAD54L, BCL10
cellular component organization (GO:0016043) 1.246BRAF, PRF1, RAD54B, TP53, RAD54L, BCL10
macromolecule metabolic process (GO:0043170) 0.836CASP10, BRAF, TP53, RAD54B, RAD54L, BCL10
organic substance metabolic process (GO:0071704) 0.636CASP10, BRAF, TP53, RAD54B, RAD54L, BCL10
metabolic process (GO:0008152) 0.586CASP10, BRAF, TP53, RAD54B, RAD54L, BCL10
cellular component organization or biogenesis (GO:0071840) 1.226BRAF, PRF1, RAD54B, TP53, RAD54L, BCL10
response to chemical (GO:0042221) 1.985RAD54B, RAD54L, BCL10, BRAF, TP53
cellular response to stimulus (GO:0051716) 1.975RAD54L, BCL10, RAD54B, TP53, BRAF
single-organism cellular process (GO:0044763) 0.655PRF1, BRAF, BCL10, TP53, CASP10
response to stress (GO:0006950) 1.85PRF1, RAD54L, BCL10, RAD54B, TP53
response to abiotic stimulus (GO:0009628) 2.85RAD54L, BCL10, RAD54B, TP53, BRAF
cellular component assembly (GO:0022607) 2.144BRAF, BCL10, PRF1, TP53
macromolecular complex subunit organization (GO:0043933) 2.144BRAF, BCL10, PRF1, TP53
response to radiation (GO:0009314) 3.694RAD54B, RAD54L, BRAF, TP53
positive regulation of cell communication (GO:0010647) 2.414BRAF, BCL10, TP53, CASP10
positive regulation of response to stimulus (GO:0048584) 2.184BRAF, BCL10, TP53, CASP10
regulation of response to stimulus (GO:0048583) 1.544BRAF, BCL10, TP53, CASP10
positive regulation of signaling (GO:0023056) 2.414BRAF, BCL10, TP53, CASP10
multicellular organismal process (GO:0032501) 1.454RAD54B, RAD54L, BRAF, TP53
signal transduction (GO:0007165) 1.284BRAF, BCL10, TP53, CASP10
regulation of signaling (GO:0023051) 1.724BRAF, BCL10, TP53, CASP10
cell death (GO:0008219) 3.054PRF1, BCL10, TP53, CASP10
regulation of cell communication (GO:0010646) 1.734BRAF, BCL10, TP53, CASP10
regulation of apoptotic process (GO:0042981) 2.54BRAF, BCL10, TP53, CASP10
regulation of biological process (GO:0050789) 0.454BRAF, BCL10, TP53, CASP10
regulation of cell death (GO:0010941) 2.434BRAF, BCL10, TP53, CASP10
cellular macromolecule metabolic process (GO:0044260) 0.934RAD54B, RAD54L, BRAF, TP53
regulation of signal transduction (GO:0009966) 1.844BRAF, BCL10, TP53, CASP10
positive regulation of signal transduction (GO:0009967) 2.54BRAF, BCL10, TP53, CASP10
macromolecular complex assembly (GO:0065003) 2.554BRAF, BCL10, PRF1, TP53
regulation of programmed cell death (GO:0043067) 2.494BRAF, BCL10, TP53, CASP10
biological regulation (GO:0065007) 0.394BRAF, BCL10, TP53, CASP10
positive regulation of biological process (GO:0048518) 1.24BRAF, BCL10, TP53, CASP10
apoptotic process (GO:0006915) 3.144PRF1, BCL10, TP53, CASP10
protein complex assembly (GO:0006461) 2.784BRAF, BCL10, PRF1, TP53
regulation of cellular process (GO:0050794) 0.54BRAF, BCL10, TP53, CASP10
programmed cell death (GO:0012501) 3.14PRF1, BCL10, TP53, CASP10
positive regulation of intracellular signal transduction (GO:1902533) 2.954BRAF, BCL10, TP53, CASP10
regulation of intracellular signal transduction (GO:1902531) 2.314BRAF, BCL10, TP53, CASP10
protein oligomerization (GO:0051259) 3.714BRAF, BCL10, PRF1, TP53
protein complex subunit organization (GO:0071822) 2.64BRAF, BCL10, PRF1, TP53
single-multicellular organism process (GO:0044707) 1.784RAD54B, RAD54L, BRAF, TP53
protein metabolic process (GO:0019538) 1.454BRAF, BCL10, TP53, CASP10
response to drug (GO:0042493) 3.714RAD54B, RAD54L, BRAF, TP53
cellular metabolic process (GO:0044237) 0.694RAD54B, RAD54L, BRAF, TP53
positive regulation of cellular process (GO:0048522) 1.34BRAF, BCL10, TP53, CASP10
regulation of phosphate metabolic process (GO:0019220) 2.353BRAF, BCL10, TP53
positive regulation of metabolic process (GO:0009893) 1.743BRAF, BCL10, TP53
regulation of metabolic process (GO:0019222) 1.023BRAF, BCL10, TP53
positive regulation of cellular metabolic process (GO:0031325) 1.813BRAF, BCL10, TP53
cell differentiation (GO:0030154) 2.143BRAF, TP53, CASP10
regulation of cellular metabolic process (GO:0031323) 1.073BRAF, BCL10, TP53
nucleic acid metabolic process (GO:0090304) 1.463RAD54L, RAD54B, TP53
cellular nitrogen compound metabolic process (GO:0034641) 1.223RAD54L, RAD54B, TP53
nitrogen compound metabolic process (GO:0006807) 1.133RAD54L, RAD54B, TP53
cell cycle process (GO:0022402) 2.753RAD54L, RAD54B, TP53
intracellular signal transduction (GO:0035556) 2.393BRAF, BCL10, TP53
organic cyclic compound metabolic process (GO:1901360) 1.263RAD54L, RAD54B, TP53
regulation of primary metabolic process (GO:0080090) 1.083BRAF, BCL10, TP53
nucleobase-containing compound metabolic process (GO:0006139) 1.353RAD54L, RAD54B, TP53
response to ionizing radiation (GO:0010212) 4.743RAD54L, RAD54B, TP53
positive regulation of macromolecule metabolic process (GO:0010604) 1.813BRAF, BCL10, TP53
cellular developmental process (GO:0048869) 1.823BRAF, TP53, CASP10
positive regulation of phosphorus metabolic process (GO:0010562) 2.783BRAF, BCL10, TP53
regulation of protein metabolic process (GO:0051246) 1.933BRAF, BCL10, TP53
positive regulation of protein metabolic process (GO:0051247) 2.433BRAF, BCL10, TP53
regulation of molecular function (GO:0065009) 1.783BRAF, BCL10, TP53
negative regulation of apoptotic process (GO:0043066) 3.043BRAF, BCL10, TP53
positive regulation of cellular protein metabolic process (GO:0032270) 2.493BRAF, BCL10, TP53
regulation of protein modification process (GO:0031399) 2.323BRAF, BCL10, TP53
negative regulation of biological process (GO:0048519) 1.333BRAF, BCL10, TP53
regulation of phosphorus metabolic process (GO:0051174) 2.353BRAF, BCL10, TP53
regulation of biological quality (GO:0065008) 1.683BRAF, BCL10, TP53
negative regulation of programmed cell death (GO:0043069) 3.023BRAF, BCL10, TP53
regulation of gene expression (GO:0010468) 1.373BRAF, BCL10, TP53
developmental process (GO:0032502) 1.363BRAF, BCL10, TP53
organelle organization (GO:0006996) 2.023RAD54L, RAD54B, TP53
positive regulation of phosphate metabolic process (GO:0045937) 2.783BRAF, BCL10, TP53
DNA repair (GO:0006281) 3.593RAD54L, RAD54B, TP53
regulation of macromolecule metabolic process (GO:0060255) 1.083BRAF, BCL10, TP53
negative regulation of cell death (GO:0060548) 2.953BRAF, BCL10, TP53
regulation of catalytic activity (GO:0050790) 1.973BRAF, BCL10, TP53
cellular aromatic compound metabolic process (GO:0006725) 1.33RAD54L, RAD54B, TP53
single-organism developmental process (GO:0044767) 1.493BRAF, BCL10, TP53
determination of adult lifespan (GO:0008340) 7.093RAD54L, RAD54B, TP53
localization (GO:0051179) 1.43BRAF, PRF1, TP53
multi-organism process (GO:0051704) 2.653BCL10, PRF1, TP53
regulation of phosphorylation (GO:0042325) 2.53BRAF, BCL10, TP53
cellular response to DNA damage stimulus (GO:0006974) 3.173RAD54L, RAD54B, TP53
positive regulation of phosphorylation (GO:0042327) 2.93BRAF, BCL10, TP53
regulation of cellular protein metabolic process (GO:0032268) 1.993BRAF, BCL10, TP53
response to biotic stimulus (GO:0009607) 3.093BCL10, PRF1, TP53
response to external stimulus (GO:0009605) 2.553BCL10, PRF1, TP53
positive regulation of protein modification process (GO:0031401) 2.73BRAF, BCL10, TP53
heterocycle metabolic process (GO:0046483) 1.313RAD54L, RAD54B, TP53
immune system process (GO:0002376) 2.293BRAF, BCL10, PRF1
positive regulation of gene expression (GO:0010628) 2.353BRAF, BCL10, TP53
cellular response to stress (GO:0033554) 2.513RAD54L, RAD54B, TP53
DNA metabolic process (GO:0006259) 3.093RAD54L, RAD54B, TP53
negative regulation of cellular process (GO:0048523) 1.413BRAF, BCL10, TP53
positive regulation of apoptotic signaling pathway (GO:2001235) 4.582BCL10, TP53
regulation of apoptotic signaling pathway (GO:2001233) 3.832BCL10, TP53
regulation of transport (GO:0051049) 2.242BRAF, TP53
behavior (GO:0007610) 3.472BRAF, TP53
regulation of neuron apoptotic process (GO:0043523) 4.472BRAF, TP53
cell surface receptor signaling pathway (GO:0007166) 2.092BCL10, CASP10
double-strand break repair (GO:0006302) 4.732RAD54L, RAD54B
response to external biotic stimulus (GO:0043207) 3.132BCL10, PRF1
positive regulation of cell adhesion (GO:0045785) 3.792BRAF, BCL10
interspecies interaction between organisms (GO:0044419) 3.082PRF1, TP53
positive regulation of molecular function (GO:0044093) 2.232BRAF, BCL10
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462BCL10, TP53
regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043122) 4.272BCL10, CASP10
positive regulation of I-kappaB kinase/NF-kappaB signaling (GO:0043123) 4.542BCL10, CASP10
regulation of cell proliferation (GO:0042127) 2.412BRAF, TP53
regulation of lymphocyte apoptotic process (GO:0070228) 5.72BCL10, TP53
protein heterooligomerization (GO:0051291) 5.222BRAF, BCL10
regulation of RNA biosynthetic process (GO:2001141) 1.552BCL10, TP53
response to other organism (GO:0051707) 3.482BCL10, PRF1
response to organic substance (GO:0010033) 2.22BRAF, BCL10
positive regulation of organelle organization (GO:0010638) 3.382BRAF, TP53
response to nutrient levels (GO:0031667) 3.772BCL10, TP53
positive regulation of biosynthetic process (GO:0009891) 2.292BCL10, TP53
cellular protein metabolic process (GO:0044267) 1.632BRAF, TP53
cellular response to abiotic stimulus (GO:0071214) 4.152BCL10, TP53
positive regulation of cellular component organization (GO:0051130) 2.682BRAF, TP53
transport (GO:0006810) 1.512BRAF, PRF1
regulation of biosynthetic process (GO:0009889) 1.372BCL10, TP53
defense response (GO:0006952) 2.782BCL10, PRF1
macromolecule modification (GO:0043412) 1.732BRAF, TP53
protein modification process (GO:0036211) 1.792BRAF, TP53
regulation of multicellular organismal process (GO:0051239) 1.872BRAF, BCL10
immune response (GO:0006955) 2.862BCL10, PRF1
regulation of neuron death (GO:1901214) 4.192BRAF, TP53
establishment of localization (GO:0051234) 1.482BRAF, PRF1
leukocyte differentiation (GO:0002521) 4.132BRAF, CASP10
anatomical structure development (GO:0048856) 1.582BRAF, TP53
regulation of hydrolase activity (GO:0051336) 2.532BCL10, TP53
regulation of response to stress (GO:0080134) 2.532BRAF, BCL10
regulation of transferase activity (GO:0051338) 2.882BRAF, TP53
DNA strand renaturation (GO:0000733) 7.532RAD54L, TP53
regulation of transcription, DNA-templated (GO:0006355) 1.562BCL10, TP53
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392BCL10, TP53
regulation of macromolecule biosynthetic process (GO:0010556) 1.432BCL10, TP53
regulation of organelle organization (GO:0033043) 2.722BRAF, TP53
regulation of cell adhesion (GO:0030155) 3.272BRAF, BCL10
regulation of cellular component organization (GO:0051128) 2.012BRAF, TP53
response to light stimulus (GO:0009416) 4.082BRAF, TP53
cellular response to chemical stimulus (GO:0070887) 2.572BRAF, TP53
positive regulation of catalytic activity (GO:0043085) 2.42BRAF, BCL10
recombinational repair (GO:0000725) 5.372RAD54L, RAD54B
double-strand break repair via homologous recombination (GO:0000724) 5.382RAD54L, RAD54B
positive regulation of multicellular organismal process (GO:0051240) 2.492BRAF, BCL10
proteolysis (GO:0006508) 2.732TP53, CASP10
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562BCL10, TP53
cellular response to external stimulus (GO:0071496) 4.22BCL10, TP53
regulation of nucleic acid-templated transcription (GO:1903506) 1.552BCL10, TP53
positive regulation of transcription, DNA-templated (GO:0045893) 2.562BCL10, TP53
regulation of localization (GO:0032879) 1.942BRAF, TP53
regulation of RNA metabolic process (GO:0051252) 1.522BCL10, TP53
positive regulation of RNA metabolic process (GO:0051254) 2.512BCL10, TP53
positive regulation of RNA biosynthetic process (GO:1902680) 2.542BCL10, TP53
response to extracellular stimulus (GO:0009991) 3.712BCL10, TP53
cellular defense response (GO:0006968) 5.652BCL10, PRF1
regulation of cellular localization (GO:0060341) 3.032BRAF, TP53
positive regulation of cellular biosynthetic process (GO:0031328) 2.32BCL10, TP53
regulation of cellular biosynthetic process (GO:0031326) 1.382BCL10, TP53
apoptotic signaling pathway (GO:0097190) 4.122TP53, CASP10
meiotic cell cycle process (GO:1903046) 4.712RAD54L, RAD54B
cellular response to drug (GO:0035690) 5.482BRAF, TP53
positive regulation of cell death (GO:0010942) 3.322BCL10, TP53
protein homooligomerization (GO:0051260) 4.212BCL10, PRF1
positive regulation of apoptotic process (GO:0043065) 3.382BCL10, TP53
positive regulation of programmed cell death (GO:0043068) 3.382BCL10, TP53
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352BCL10, TP53
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432BCL10, TP53
cellular protein modification process (GO:0006464) 1.792BRAF, TP53
reproductive process (GO:0022414) 2.552RAD54L, RAD54B
biosynthetic process (GO:0009058) 1.322BCL10, TP53
multi-organism cellular process (GO:0044764) 3.142PRF1, TP53
regulation of nitrogen compound metabolic process (GO:0051171) 1.362BCL10, TP53
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292BCL10, TP53
DNA recombination (GO:0006310) 4.392RAD54L, RAD54B
chromosome organization (GO:0051276) 3.792RAD54L, RAD54B
regulation of leukocyte apoptotic process (GO:2000106) 5.332BCL10, TP53
regulation of cellular component biogenesis (GO:0044087) 3.082BRAF, TP53
viral process (GO:0016032) 3.152PRF1, TP53
immune effector process (GO:0002252) 3.582BCL10, PRF1
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152PRF1, TP53
regulation of protein phosphorylation (GO:0001932) 2.572BRAF, TP53
positive regulation of protein phosphorylation (GO:0001934) 2.952BRAF, TP53
positive regulation of cellular component biogenesis (GO:0044089) 3.712BRAF, TP53

NET-GE enrichment

Term New enriched termICP valueGenes
protein oligomerization (GO:0051259) -3.710.004BRAF, BCL10, PRF1, TP53
apoptotic process (GO:0006915) -3.140.044PRF1, BCL10, TP53, CASP10
double-strand break repair (GO:0006302) -4.730.006RAD54L, RAD54B, TP53
DNA strand renaturation (GO:0000733) -7.530.003RAD54L, TP53
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.287CASP10, BRAF, PRF1, RAD54B, TP53, RAD54L, BCL10
cell part (GO:0044464) 0.117CASP10, BRAF, TP53, RAD54B, PRF1, RAD54L, BCL10
intracellular organelle (GO:0043229) 0.516BRAF, PRF1, RAD54B, TP53, RAD54L, BCL10
membrane-bounded organelle (GO:0043227) 0.476BRAF, PRF1, RAD54B, TP53, RAD54L, BCL10
intracellular membrane-bounded organelle (GO:0043231) 0.66BRAF, PRF1, RAD54B, TP53, RAD54L, BCL10
organelle (GO:0043226) 0.46BRAF, PRF1, RAD54B, TP53, RAD54L, BCL10
cytoplasmic part (GO:0044444) 0.825PRF1, BRAF, BCL10, TP53, CASP10
nucleus (GO:0005634) 1.075RAD54L, BCL10, RAD54B, TP53, BRAF
intracellular organelle part (GO:0044446) 0.814RAD54L, BCL10, PRF1, TP53
membrane part (GO:0044425) 0.954PRF1, BCL10, TP53, CASP10
cytosol (GO:0005829) 1.684BRAF, BCL10, TP53, CASP10
membrane (GO:0016020) 0.684BRAF, BCL10, PRF1, TP53
organelle part (GO:0044422) 0.794RAD54L, BCL10, PRF1, TP53
protein complex (GO:0043234) 1.513BCL10, TP53, CASP10
cytoplasm (GO:0005737) 1.013BRAF, BCL10, TP53
macromolecular complex (GO:0032991) 1.353BCL10, TP53, CASP10
plasma membrane (GO:0005886) 1.393BRAF, BCL10, PRF1
plasma membrane protein complex (GO:0098797) 3.552BCL10, CASP10
membrane protein complex (GO:0098796) 2.842BCL10, CASP10
lytic vacuole (GO:0000323) 3.892BCL10, PRF1
organelle lumen (GO:0043233) 3.052PRF1, TP53
vacuole (GO:0005773) 2.922BCL10, PRF1
integral component of membrane (GO:0016021) 1.142PRF1, TP53
membrane-enclosed lumen (GO:0031974) 3.052PRF1, TP53
nucleoplasm (GO:0005654) 1.892RAD54L, TP53
intracellular organelle lumen (GO:0070013) 3.052PRF1, TP53
nuclear part (GO:0044428) 1.552RAD54L, TP53
mitochondrion (GO:0005739) 2.422BRAF, TP53
lysosome (GO:0005764) 3.892BCL10, PRF1
plasma membrane part (GO:0044459) 1.952BCL10, CASP10
intrinsic component of membrane (GO:0031224) 1.132PRF1, TP53