Disease table of LEOPARD SYNDROME OMIM ID: PS151100

Gene-disease associations table

GeneAssociated with LEOPARD SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PTPN11ClinVar, OMIM, HUMSAVARHGNC link12q24.134PS163950, 607785, 156250, PS151100
RAF1ClinVar, OMIM, HUMSAVARHGNC link3p25.23PS163950, PS115200, PS151100
BRAFClinVar, OMIM, HUMSAVARHGNC link7q348605027, PS115150, PS151100, PS155600, 211980, PS188550, PS163950, 114500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PTPN11RAF1No7PDGFRB, MAP2K1, JAK1, JAK2, MAP3K5, EGFR, FYN
PTPN11BRAFNo1MAP2K1
RAF1BRAFYes26MAP2K2, CDC37, YWHAE, MAPK1, BRAF, NEDD4L, KSR1, RAP1A, HSPA5, YWHAB, YWHAH, PRKCE, BRAP, RAF1, YWHAZ, HRAS, HSP90AA1, AKT1, BAD, HSPA8, MRAS, MAPK3, YWHAG, SFN, YWHAQ, MAP2K1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PTPN11RAF1No-50PIK3R3, FCER1A, RAP1A, MS4A2, PRKCZ, MAPK3, TP53, MAPK1, JAK2, SRC, KRAS, PIK3CG, PRKACA, RAP1B, FCER1G, RPS27A, STAT2, PDGFRB, CXCL12, MAP2K2, PIK3CA, UBA52, MAPK7, INPP5D, LCK, HRAS, NOS3, VAV1, PIK3CB, DOK1, PPP2CA, AKT1, RHOA, PPP2R1A, FYN, MYC, STAT3, IL2, UBB, IL3, IGF1R, HSPA4, GNB2L1, SPRY2, JAK1, IGF1, UBC, PIK3CD, PIK3R5, MAP2K1
PTPN11BRAFNo-15MAP2K2, AKT1, CRK, MAPK1, HRAS, MAPK3, PPP2CA, SPRY2, UBC, KRAS, RAP1A, PPP2R1A, PRKACA, RAP1B, MAP2K1
RAF1BRAFYesbinding40MAP2K2, HSP90AB1, CDC37, KSR2, YWHAE, MAPK1, PPP2CA, PAK2, KSR1, RAP1A, PRKACA, RAP1B, YWHAB, PRKCE, PRKCD, YWHAH, RRAS, CNKSR3, PRKCG, RHEB, YWHAZ, PRKCA, HRAS, HSP90AA1, PPP2R2B, AKT1, PAK4, PPP2R1A, KRAS, PRKCB, MRAS, MAPK3, SPRY2, YWHAG, SFN, UBC, PRKCQ, PIN1, YWHAQ, MAP2K1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
RAF1BRAFYesRAF1-BRAF complex, RAS stimulated;BRAF-RAF1-14-3-3 complex;MAP2K1-BRAF-RAF1-YWHAE-KSR1 complex11MAP2K2, YWHAH, YWHAE, KSR1, YWHAG, YWHAB, SFN, CNKSR1, YWHAQ, MAP2K1, YWHAZ

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Neurotrophin signaling pathwayhsa047225.783PTPN11, BRAF, RAF1
Natural killer cell mediated cytotoxicityhsa046505.533PTPN11, BRAF, RAF1
Renal cell carcinomahsa052116.63PTPN11, BRAF, RAF1
Proteoglycans in cancerhsa052055.023PTPN11, BRAF, RAF1
Chronic myeloid leukemiahsa052206.483PTPN11, BRAF, RAF1
Melanomahsa052186.562BRAF, RAF1
Bladder cancerhsa052197.382BRAF, RAF1
Focal adhesionhsa045104.922BRAF, RAF1
Pancreatic cancerhsa052126.562BRAF, RAF1
Endometrial cancerhsa052136.812BRAF, RAF1
Colorectal cancerhsa052106.522BRAF, RAF1
Gliomahsa052146.662BRAF, RAF1
Prostate cancerhsa052156.112BRAF, RAF1
Long-term potentiationhsa047206.642BRAF, RAF1
FoxO signaling pathwayhsa040685.632BRAF, RAF1
Serotonergic synapsehsa047265.842BRAF, RAF1
Chemokine signaling pathwayhsa040625.192BRAF, RAF1
Progesterone-mediated oocyte maturationhsa049146.182BRAF, RAF1
Hepatitis Chsa051605.682BRAF, RAF1
Vascular smooth muscle contractionhsa042705.742BRAF, RAF1
Pathways in cancerhsa052003.982BRAF, RAF1
Rap1 signaling pathwayhsa040154.972BRAF, RAF1
Ras signaling pathwayhsa040144.92PTPN11, RAF1
Non-small cell lung cancerhsa052236.882BRAF, RAF1
ErbB signaling pathwayhsa040126.152BRAF, RAF1
Acute myeloid leukemiahsa052216.742BRAF, RAF1
MAPK signaling pathwayhsa040104.632BRAF, RAF1
Long-term depressionhsa047306.742BRAF, RAF1
Regulation of actin cytoskeletonhsa048104.92BRAF, RAF1
Insulin signaling pathwayhsa049105.552BRAF, RAF1
cAMP signaling pathwayhsa040245.052BRAF, RAF1
Alcoholismhsa050345.592BRAF, RAF1

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) -6.560.025BRAF, RAF1
Bladder cancer (hsa05219) -7.380.018BRAF, RAF1
Progesterone-mediated oocyte maturation (hsa04914) -6.180.043BRAF, RAF1
Pancreatic cancer (hsa05212) -6.560.025BRAF, RAF1
Natural killer cell mediated cytotoxicity (hsa04650) -5.530.003PTPN11, BRAF, RAF1
Colorectal cancer (hsa05210) -6.520.027BRAF, RAF1
Renal cell carcinoma (hsa05211) -6.60.0PTPN11, BRAF, RAF1
cAMP signaling pathway (hsa04024) -5.050.02PTPN11, BRAF, RAF1
Prostate cancer (hsa05215) -6.110.048BRAF, RAF1
Long-term potentiation (hsa04720) -6.640.023BRAF, RAF1
Neurotrophin signaling pathway (hsa04722) -5.780.003PTPN11, BRAF, RAF1
Circulatory systemNEW4.630.039PTPN11, BRAF, RAF1
FoxO signaling pathway (hsa04068) -5.630.007PTPN11, BRAF, RAF1
Endometrial cancer (hsa05213) -6.810.045BRAF, RAF1
Hepatitis C (hsa05160) -5.680.004PTPN11, BRAF, RAF1
Cancers: Specific typesNEW4.10.015PTPN11, BRAF, RAF1
Glioma (hsa05214) -6.660.022BRAF, RAF1
Proteoglycans in cancer (hsa05205) -5.020.002PTPN11, BRAF, RAF1
Rap1 signaling pathway (hsa04015) -4.970.028PTPN11, BRAF, RAF1
Ras signaling pathway (hsa04014) -4.90.025PTPN11, BRAF, RAF1
Non-small cell lung cancer (hsa05223) -6.880.016BRAF, RAF1
ErbB signaling pathway (hsa04012) -6.150.045BRAF, RAF1
Acute myeloid leukemia (hsa05221) -6.740.02BRAF, RAF1
Chronic myeloid leukemia (hsa05220) -6.480.0PTPN11, BRAF, RAF1
Long-term depression (hsa04730) -6.740.02BRAF, RAF1
Nervous systemNEW3.770.03PTPN11, BRAF, RAF1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.853PTPN11, BRAF, RAF1
Signaling by InterleukinsR-HSA-4491474.713PTPN11, BRAF, RAF1
Signaling by LeptinR-HSA-25865525.13PTPN11, BRAF, RAF1
Cytokine Signaling in Immune systemR-HSA-12802153.743PTPN11, BRAF, RAF1
IGF1R signaling cascadeR-HSA-24289244.853PTPN11, BRAF, RAF1
Downstream signal transductionR-HSA-1867634.653PTPN11, BRAF, RAF1
IRS-related events triggered by IGF1RR-HSA-24289284.853PTPN11, BRAF, RAF1
Signaling by ERBB4R-HSA-12363944.73PTPN11, BRAF, RAF1
Signaling by Insulin receptorR-HSA-747524.733PTPN11, BRAF, RAF1
Developmental BiologyR-HSA-12667383.483PTPN11, BRAF, RAF1
Insulin receptor signalling cascadeR-HSA-747514.853PTPN11, BRAF, RAF1
Downstream signaling of activated FGFR1R-HSA-56546874.713PTPN11, BRAF, RAF1
MAPK family signaling cascadesR-HSA-56830574.893PTPN11, BRAF, RAF1
Signalling by NGFR-HSA-1665204.233PTPN11, BRAF, RAF1
MAPK1/MAPK3 signalingR-HSA-56849965.113PTPN11, BRAF, RAF1
IRS-mediated signallingR-HSA-1123994.873PTPN11, BRAF, RAF1
FRS-mediated FGFR2 signalingR-HSA-56547005.143PTPN11, BRAF, RAF1
FRS-mediated FGFR4 signalingR-HSA-56547125.143PTPN11, BRAF, RAF1
FRS-mediated FGFR3 signalingR-HSA-56547065.143PTPN11, BRAF, RAF1
Downstream signaling of activated FGFR3R-HSA-56547084.713PTPN11, BRAF, RAF1
Signaling by FGFR4R-HSA-56547434.693PTPN11, BRAF, RAF1
Signaling by FGFR3R-HSA-56547414.693PTPN11, BRAF, RAF1
Signaling by FGFRR-HSA-1902364.673PTPN11, BRAF, RAF1
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.033PTPN11, BRAF, RAF1
Immune SystemR-HSA-1682562.373PTPN11, BRAF, RAF1
Innate Immune SystemR-HSA-1682493.173PTPN11, BRAF, RAF1
Signaling by SCF-KITR-HSA-14335574.733PTPN11, BRAF, RAF1
Signaling by PDGFR-HSA-1867974.533PTPN11, BRAF, RAF1
DAP12 signalingR-HSA-24244914.643PTPN11, BRAF, RAF1
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.993PTPN11, BRAF, RAF1
Downstream signaling of activated FGFR2R-HSA-56546964.713PTPN11, BRAF, RAF1
Signaling by EGFRR-HSA-1779294.593PTPN11, BRAF, RAF1
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.513PTPN11, BRAF, RAF1
FRS-mediated FGFR1 signalingR-HSA-56546935.143PTPN11, BRAF, RAF1
Signaling by FGFR2R-HSA-56547384.683PTPN11, BRAF, RAF1
Signaling by FGFR1R-HSA-56547364.693PTPN11, BRAF, RAF1
DAP12 interactionsR-HSA-21721274.563PTPN11, BRAF, RAF1
Downstream signaling of activated FGFR4R-HSA-56547164.713PTPN11, BRAF, RAF1
Signaling by ERBB2R-HSA-12279864.663PTPN11, BRAF, RAF1
Axon guidanceR-HSA-4224753.933PTPN11, BRAF, RAF1
Signal TransductionR-HSA-1625821.783PTPN11, BRAF, RAF1
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.262BRAF, RAF1
Interleukin-2 signalingR-HSA-4519275.052BRAF, RAF1
Frs2-mediated activationR-HSA-1709685.122BRAF, RAF1
MAP2K and MAPK activationR-HSA-56741357.662BRAF, RAF1
Post NMDA receptor activation eventsR-HSA-4380647.852BRAF, RAF1
CREB phosphorylation through the activation of RasR-HSA-4427428.232BRAF, RAF1
RAF activationR-HSA-56730008.342BRAF, RAF1
RAF/MAP kinase cascadeR-HSA-56730015.152BRAF, RAF1
Signaling by VEGFR-HSA-1941384.662BRAF, RAF1
Signalling to p38 via RIT and RINR-HSA-1877065.122BRAF, RAF1
Platelet activation, signaling and aggregationR-HSA-760025.152PTPN11, RAF1
FCERI mediated MAPK activationR-HSA-28717964.322BRAF, RAF1
Negative regulation of FGFR1 signalingR-HSA-56547267.982PTPN11, BRAF
Negative regulation of FGFR2 signalingR-HSA-56547277.892PTPN11, BRAF
Adaptive Immune SystemR-HSA-12802183.192PTPN11, RAF1
Neuronal SystemR-HSA-1123164.822BRAF, RAF1
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellR-HSA-1123145.852BRAF, RAF1
Transmission across Chemical SynapsesR-HSA-1123155.282BRAF, RAF1
VEGFA-VEGFR2 PathwayR-HSA-44200974.72BRAF, RAF1
Spry regulation of FGF signalingR-HSA-12955969.182PTPN11, BRAF
GRB2 events in ERBB2 signalingR-HSA-19636405.152BRAF, RAF1
Interleukin receptor SHC signalingR-HSA-9125265.092BRAF, RAF1
Negative feedback regulation of MAPK pathwayR-HSA-567449910.42BRAF, RAF1
NCAM signaling for neurite out-growthR-HSA-3751654.92BRAF, RAF1
Signalling to RASR-HSA-1670445.082BRAF, RAF1
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsR-HSA-4427557.72BRAF, RAF1
SHC1 events in EGFR signalingR-HSA-1803365.152BRAF, RAF1
Prolonged ERK activation eventsR-HSA-1698935.112BRAF, RAF1
Negative regulation of MAPK pathwayR-HSA-56752217.662BRAF, RAF1
Signalling to ERKsR-HSA-1876875.042BRAF, RAF1
Signaling by GPCRR-HSA-3727902.682BRAF, RAF1
GRB2 events in EGFR signalingR-HSA-1798125.152BRAF, RAF1
SHC1 events in ERBB2 signalingR-HSA-12501965.152BRAF, RAF1
Negative regulation of FGFR4 signalingR-HSA-56547338.032PTPN11, BRAF
Negative regulation of FGFR3 signalingR-HSA-56547328.122PTPN11, BRAF
ARMS-mediated activationR-HSA-1709845.122BRAF, RAF1
SOS-mediated signallingR-HSA-1124125.152BRAF, RAF1
SHC1 events in ERBB4 signalingR-HSA-12503475.152BRAF, RAF1
VEGFR2 mediated cell proliferationR-HSA-52189215.072BRAF, RAF1
HemostasisR-HSA-1095823.982PTPN11, RAF1

NET-GE enrichment

Term New enriched termICP valueGenes
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192) -4.850.006PTPN11, BRAF, RAF1
NCAM signaling for neurite out-growth (R-HSA-375165) -4.90.044PTPN11, BRAF, RAF1
Signaling by Interleukins (R-HSA-449147) -4.710.008PTPN11, BRAF, RAF1
Interleukin-2 signaling (R-HSA-451927) -5.050.026PTPN11, BRAF, RAF1
Negative feedback regulation of MAPK pathway (R-HSA-5674499) -10.40.0BRAF, RAF1
MAP2K and MAPK activation (R-HSA-5674135) -7.660.01BRAF, RAF1
SOS-mediated signalling (R-HSA-112412) -5.150.022PTPN11, BRAF, RAF1
IGF1R signaling cascade (R-HSA-2428924) -4.850.006PTPN11, BRAF, RAF1
Downstream signal transduction (R-HSA-186763) -4.650.009PTPN11, BRAF, RAF1
Post NMDA receptor activation events (R-HSA-438064) -7.850.008BRAF, RAF1
IRS-related events triggered by IGF1R (R-HSA-2428928) -4.850.006PTPN11, BRAF, RAF1
Signaling by ERBB4 (R-HSA-1236394) -4.70.008PTPN11, BRAF, RAF1
IRS-mediated signalling (R-HSA-112399) -4.870.006PTPN11, BRAF, RAF1
MAPK1/MAPK3 signaling (R-HSA-5684996) -5.110.003PTPN11, BRAF, RAF1
CREB phosphorylation through the activation of Ras (R-HSA-442742) -8.230.004BRAF, RAF1
RAF activation (R-HSA-5673000) -8.340.007BRAF, RAF1
Insulin receptor signalling cascade (R-HSA-74751) -4.850.048PTPN11, BRAF, RAF1
Downstream signaling of activated FGFR1 (R-HSA-5654687) -4.710.008PTPN11, BRAF, RAF1
MAPK family signaling cascades (R-HSA-5683057) -4.890.041PTPN11, BRAF, RAF1
Signaling by Leptin (R-HSA-2586552) -5.10.024PTPN11, BRAF, RAF1
Signalling to p38 via RIT and RIN (R-HSA-187706) -5.120.023PTPN11, BRAF, RAF1
Platelet activation, signaling and aggregation (R-HSA-76002) -5.150.032PTPN11, BRAF, RAF1
Negative regulation of FGFR1 signaling (R-HSA-5654726) -7.980.006PTPN11, BRAF
Negative regulation of FGFR2 signaling (R-HSA-5654727) -7.890.007PTPN11, BRAF
FRS-mediated FGFR2 signaling (R-HSA-5654700) -5.140.022PTPN11, BRAF, RAF1
DAP12 interactions (R-HSA-2172127) -4.560.01PTPN11, BRAF, RAF1
FRS-mediated FGFR3 signaling (R-HSA-5654706) -5.140.022PTPN11, BRAF, RAF1
Signaling by Insulin receptor (R-HSA-74752) -4.730.007PTPN11, BRAF, RAF1
Downstream signaling of activated FGFR3 (R-HSA-5654708) -4.710.008PTPN11, BRAF, RAF1
RAF/MAP kinase cascade (R-HSA-5673001) -5.150.022PTPN11, BRAF, RAF1
Signaling by FGFR4 (R-HSA-5654743) -4.690.008PTPN11, BRAF, RAF1
Signaling by FGFR3 (R-HSA-5654741) -4.690.008PTPN11, BRAF, RAF1
Signaling by FGFR (R-HSA-190236) -4.670.008PTPN11, BRAF, RAF1
Spry regulation of FGF signaling (R-HSA-1295596) -9.180.001PTPN11, BRAF
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202) -4.030.032PTPN11, BRAF, RAF1
GRB2 events in ERBB2 signaling (R-HSA-1963640) -5.150.022PTPN11, BRAF, RAF1
Interleukin receptor SHC signaling (R-HSA-912526) -5.090.024PTPN11, BRAF, RAF1
Signaling by SCF-KIT (R-HSA-1433557) -4.730.007PTPN11, BRAF, RAF1
Frs2-mediated activation (R-HSA-170968) -5.120.022PTPN11, BRAF, RAF1
Signaling by ERBB2 (R-HSA-1227986) -4.660.009PTPN11, BRAF, RAF1
Signalling to RAS (R-HSA-167044) -5.080.026PTPN11, BRAF, RAF1
DAP12 signaling (R-HSA-2424491) -4.640.009PTPN11, BRAF, RAF1
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988) -4.990.004PTPN11, BRAF, RAF1
Activation of NMDA receptor upon glutamate binding and postsynaptic events (R-HSA-442755) -7.70.016BRAF, RAF1
Downstream signaling of activated FGFR2 (R-HSA-5654696) -4.710.008PTPN11, BRAF, RAF1
Downstream signaling of activated FGFR4 (R-HSA-5654716) -4.710.008PTPN11, BRAF, RAF1
SHC1 events in EGFR signaling (R-HSA-180336) -5.150.022PTPN11, BRAF, RAF1
NGF signalling via TRKA from the plasma membrane (R-HSA-187037) -4.510.012PTPN11, BRAF, RAF1
FRS-mediated FGFR1 signaling (R-HSA-5654693) -5.140.022PTPN11, BRAF, RAF1
Prolonged ERK activation events (R-HSA-169893) -5.110.023PTPN11, BRAF, RAF1
Negative regulation of MAPK pathway (R-HSA-5675221) -7.660.022BRAF, RAF1
Signalling by NGF (R-HSA-166520) -4.230.021PTPN11, BRAF, RAF1
Signaling by FGFR1 (R-HSA-5654736) -4.690.008PTPN11, BRAF, RAF1
Signaling by FGFR2 (R-HSA-5654738) -4.680.008PTPN11, BRAF, RAF1
GRB2 events in EGFR signaling (R-HSA-179812) -5.150.022PTPN11, BRAF, RAF1
Signalling to ERKs (R-HSA-187687) -5.040.029PTPN11, BRAF, RAF1
SHC1 events in ERBB2 signaling (R-HSA-1250196) -5.150.022PTPN11, BRAF, RAF1
Negative regulation of FGFR4 signaling (R-HSA-5654733) -8.030.006PTPN11, BRAF
Negative regulation of FGFR3 signaling (R-HSA-5654732) -8.120.005PTPN11, BRAF
Signaling by EGFR (R-HSA-177929) -4.590.01PTPN11, BRAF, RAF1
ARMS-mediated activation (R-HSA-170984) -5.120.023PTPN11, BRAF, RAF1
FRS-mediated FGFR4 signaling (R-HSA-5654712) -5.140.022PTPN11, BRAF, RAF1
SHC1 events in ERBB4 signaling (R-HSA-1250347) -5.150.022PTPN11, BRAF, RAF1
Signaling by PDGF (R-HSA-186797) -4.530.011PTPN11, BRAF, RAF1
Axon guidance (R-HSA-422475) -3.930.039PTPN11, BRAF, RAF1
VEGFR2 mediated cell proliferation (R-HSA-5218921) -5.070.026PTPN11, BRAF, RAF1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.053PTPN11, BRAF, RAF1
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.083PTPN11, BRAF, RAF1
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.773PTPN11, BRAF, RAF1
kinase activity (GO:0016301) 2.933PTPN11, BRAF, RAF1
enzyme binding (GO:0019899) 2.273PTPN11, BRAF, RAF1
protein kinase binding (GO:0019901) 3.443PTPN11, BRAF, RAF1
kinase binding (GO:0019900) 3.323PTPN11, BRAF, RAF1
transferase activity (GO:0016740) 1.953PTPN11, BRAF, RAF1
binding (GO:0005488) 0.183PTPN11, BRAF, RAF1
protein binding (GO:0005515) 0.463PTPN11, BRAF, RAF1
purine ribonucleoside triphosphate binding (GO:0035639) 2.222BRAF, RAF1
small GTPase binding (GO:0031267) 4.132BRAF, RAF1
GTPase binding (GO:0051020) 4.052BRAF, RAF1
signal transducer activity (GO:0004871) 2.282BRAF, RAF1
ion binding (GO:0043167) 1.362BRAF, RAF1
heterocyclic compound binding (GO:1901363) 1.062BRAF, RAF1
purine nucleoside binding (GO:0001883) 2.222BRAF, RAF1
nucleoside binding (GO:0001882) 2.212BRAF, RAF1
cation binding (GO:0043169) 1.42BRAF, RAF1
mitogen-activated protein kinase kinase binding (GO:0031434) 6.972BRAF, RAF1
receptor signaling protein activity (GO:0005057) 4.762BRAF, RAF1
nucleotide binding (GO:0000166) 1.962BRAF, RAF1
protein serine/threonine kinase activity (GO:0004674) 3.642BRAF, RAF1
nucleoside phosphate binding (GO:1901265) 1.962BRAF, RAF1
ribonucleoside binding (GO:0032549) 2.222BRAF, RAF1
purine nucleotide binding (GO:0017076) 2.192BRAF, RAF1
metal ion binding (GO:0046872) 1.412BRAF, RAF1
ATP binding (GO:0005524) 2.432BRAF, RAF1
hydrolase activity (GO:0016787) 1.92PTPN11, RAF1
protein kinase activity (GO:0004672) 3.272BRAF, RAF1
hydrolase activity, acting on ester bonds (GO:0016788) 3.12PTPN11, RAF1
small molecule binding (GO:0036094) 1.892BRAF, RAF1
adenyl nucleotide binding (GO:0030554) 2.42BRAF, RAF1
carbohydrate derivative binding (GO:0097367) 2.032BRAF, RAF1
organic cyclic compound binding (GO:0097159) 1.052BRAF, RAF1
adenyl ribonucleotide binding (GO:0032559) 2.412BRAF, RAF1
identical protein binding (GO:0042802) 2.632BRAF, RAF1
receptor signaling protein serine/threonine kinase activity (GO:0004702) 5.232BRAF, RAF1
purine ribonucleotide binding (GO:0032555) 2.22BRAF, RAF1
protein dimerization activity (GO:0046983) 2.722BRAF, RAF1
protein heterodimerization activity (GO:0046982) 3.642BRAF, RAF1
MAP kinase kinase kinase activity (GO:0004709) 6.62BRAF, RAF1
purine ribonucleoside binding (GO:0032550) 2.222BRAF, RAF1
ribonucleotide binding (GO:0032553) 2.192BRAF, RAF1

NET-GE enrichment

Term New enriched termICP valueGenes
Ras guanyl-nucleotide exchange factor activity (GO:0005088) NEW4.310.001PTPN11, BRAF, RAF1
mitogen-activated protein kinase kinase binding (GO:0031434) -6.970.001BRAF, RAF1
receptor signaling protein activity (GO:0005057) -4.760.009PTPN11, BRAF, RAF1
guanyl-nucleotide exchange factor activity (GO:0005085) NEW4.020.004PTPN11, BRAF, RAF1
enzyme binding (GO:0019899) -2.270.03PTPN11, BRAF, RAF1
receptor signaling protein serine/threonine kinase activity (GO:0004702) -5.230.002BRAF, RAF1
MAP kinase kinase kinase activity (GO:0004709) -6.60.002BRAF, RAF1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of phosphate metabolic process (GO:0019220) 2.353PTPN11, BRAF, RAF1
regulation of primary metabolic process (GO:0080090) 1.083PTPN11, BRAF, RAF1
regulation of metabolic process (GO:0019222) 1.023PTPN11, BRAF, RAF1
positive regulation of response to stimulus (GO:0048584) 2.183PTPN11, BRAF, RAF1
regulation of response to stimulus (GO:0048583) 1.543PTPN11, BRAF, RAF1
activation of protein kinase activity (GO:0032147) 4.083PTPN11, BRAF, RAF1
signal transduction (GO:0007165) 1.283PTPN11, BRAF, RAF1
cellular component organization or biogenesis (GO:0071840) 1.223PTPN11, BRAF, RAF1
single-organism metabolic process (GO:0044710) 1.633PTPN11, BRAF, RAF1
positive regulation of macromolecule metabolic process (GO:0010604) 1.813PTPN11, BRAF, RAF1
regulation of signal transduction (GO:0009966) 1.843PTPN11, BRAF, RAF1
positive regulation of signal transduction (GO:0009967) 2.53PTPN11, BRAF, RAF1
animal organ development (GO:0048513) 2.533PTPN11, BRAF, RAF1
positive regulation of molecular function (GO:0044093) 2.233PTPN11, BRAF, RAF1
positive regulation of biological process (GO:0048518) 1.23PTPN11, BRAF, RAF1
negative regulation of biological process (GO:0048519) 1.333PTPN11, BRAF, RAF1
regulation of macromolecule metabolic process (GO:0060255) 1.083PTPN11, BRAF, RAF1
regulation of protein kinase activity (GO:0045859) 3.153PTPN11, BRAF, RAF1
regulation of phosphorylation (GO:0042325) 2.53PTPN11, BRAF, RAF1
positive regulation of phosphorylation (GO:0042327) 2.93PTPN11, BRAF, RAF1
single-multicellular organism process (GO:0044707) 1.783PTPN11, BRAF, RAF1
protein metabolic process (GO:0019538) 1.453PTPN11, BRAF, RAF1
immune system process (GO:0002376) 2.293PTPN11, BRAF, RAF1
positive regulation of metabolic process (GO:0009893) 1.743PTPN11, BRAF, RAF1
positive regulation of kinase activity (GO:0033674) 3.543PTPN11, BRAF, RAF1
intracellular signal transduction (GO:0035556) 2.393PTPN11, BRAF, RAF1
regulation of protein serine/threonine kinase activity (GO:0071900) 3.583PTPN11, BRAF, RAF1
regulation of biological process (GO:0050789) 0.453PTPN11, BRAF, RAF1
cellular protein metabolic process (GO:0044267) 1.633PTPN11, BRAF, RAF1
positive regulation of transferase activity (GO:0051347) 3.313PTPN11, BRAF, RAF1
cellular macromolecule metabolic process (GO:0044260) 0.933PTPN11, BRAF, RAF1
regulation of kinase activity (GO:0043549) 3.073PTPN11, BRAF, RAF1
cellular component organization (GO:0016043) 1.243PTPN11, BRAF, RAF1
biological regulation (GO:0065007) 0.393PTPN11, BRAF, RAF1
positive regulation of catalytic activity (GO:0043085) 2.43PTPN11, BRAF, RAF1
regulation of molecular function (GO:0065009) 1.783PTPN11, BRAF, RAF1
regulation of biological quality (GO:0065008) 1.683PTPN11, BRAF, RAF1
regulation of catalytic activity (GO:0050790) 1.973PTPN11, BRAF, RAF1
regulation of cellular process (GO:0050794) 0.53PTPN11, BRAF, RAF1
positive regulation of MAPK cascade (GO:0043410) 3.573PTPN11, BRAF, RAF1
macromolecule modification (GO:0043412) 1.733PTPN11, BRAF, RAF1
protein modification process (GO:0036211) 1.793PTPN11, BRAF, RAF1
metabolic process (GO:0008152) 0.583PTPN11, BRAF, RAF1
positive regulation of intracellular signal transduction (GO:1902533) 2.953PTPN11, BRAF, RAF1
regulation of intracellular signal transduction (GO:1902531) 2.313PTPN11, BRAF, RAF1
single-organism developmental process (GO:0044767) 1.493PTPN11, BRAF, RAF1
response to stimulus (GO:0050896) 1.223PTPN11, BRAF, RAF1
positive regulation of protein modification process (GO:0031401) 2.73PTPN11, BRAF, RAF1
cell activation (GO:0001775) 3.473PTPN11, BRAF, RAF1
regulation of transferase activity (GO:0051338) 2.883PTPN11, BRAF, RAF1
cellular developmental process (GO:0048869) 1.823PTPN11, BRAF, RAF1
phosphorylation (GO:0016310) 2.633PTPN11, BRAF, RAF1
cell differentiation (GO:0030154) 2.143PTPN11, BRAF, RAF1
regulation of cellular component organization (GO:0051128) 2.013PTPN11, BRAF, RAF1
positive regulation of signaling (GO:0023056) 2.413PTPN11, BRAF, RAF1
negative regulation of signaling (GO:0023057) 2.653PTPN11, BRAF, RAF1
regulation of MAP kinase activity (GO:0043405) 3.953PTPN11, BRAF, RAF1
negative regulation of cell communication (GO:0010648) 2.663PTPN11, BRAF, RAF1
regulation of signaling (GO:0023051) 1.723PTPN11, BRAF, RAF1
positive regulation of cell communication (GO:0010647) 2.413PTPN11, BRAF, RAF1
regulation of cell communication (GO:0010646) 1.733PTPN11, BRAF, RAF1
single-organism process (GO:0044699) 0.483PTPN11, BRAF, RAF1
regulation of MAPK cascade (GO:0043408) 3.223PTPN11, BRAF, RAF1
positive regulation of phosphorus metabolic process (GO:0010562) 2.783PTPN11, BRAF, RAF1
regulation of protein metabolic process (GO:0051246) 1.933PTPN11, BRAF, RAF1
positive regulation of protein metabolic process (GO:0051247) 2.433PTPN11, BRAF, RAF1
positive regulation of cellular protein metabolic process (GO:0032270) 2.493PTPN11, BRAF, RAF1
regulation of protein modification process (GO:0031399) 2.323PTPN11, BRAF, RAF1
developmental process (GO:0032502) 1.363PTPN11, BRAF, RAF1
multicellular organismal process (GO:0032501) 1.453PTPN11, BRAF, RAF1
cellular process (GO:0009987) 0.263PTPN11, BRAF, RAF1
regulation of localization (GO:0032879) 1.943PTPN11, BRAF, RAF1
regulation of cellular protein metabolic process (GO:0032268) 1.993PTPN11, BRAF, RAF1
macromolecule metabolic process (GO:0043170) 0.833PTPN11, BRAF, RAF1
positive regulation of protein kinase activity (GO:0045860) 3.613PTPN11, BRAF, RAF1
regulation of response to stress (GO:0080134) 2.533PTPN11, BRAF, RAF1
positive regulation of cellular metabolic process (GO:0031325) 1.813PTPN11, BRAF, RAF1
regulation of cellular metabolic process (GO:0031323) 1.073PTPN11, BRAF, RAF1
organic substance metabolic process (GO:0071704) 0.633PTPN11, BRAF, RAF1
positive regulation of phosphate metabolic process (GO:0045937) 2.783PTPN11, BRAF, RAF1
cellular protein modification process (GO:0006464) 1.793PTPN11, BRAF, RAF1
regulation of phosphorus metabolic process (GO:0051174) 2.353PTPN11, BRAF, RAF1
single-organism cellular process (GO:0044763) 0.653PTPN11, BRAF, RAF1
primary metabolic process (GO:0044238) 0.693PTPN11, BRAF, RAF1
anatomical structure development (GO:0048856) 1.583PTPN11, BRAF, RAF1
cellular metabolic process (GO:0044237) 0.693PTPN11, BRAF, RAF1
regulation of cellular component biogenesis (GO:0044087) 3.083PTPN11, BRAF, RAF1
phosphate-containing compound metabolic process (GO:0006796) 2.163PTPN11, BRAF, RAF1
phosphorus metabolic process (GO:0006793) 2.153PTPN11, BRAF, RAF1
regulation of protein phosphorylation (GO:0001932) 2.573PTPN11, BRAF, RAF1
positive regulation of protein phosphorylation (GO:0001934) 2.953PTPN11, BRAF, RAF1
negative regulation of cellular process (GO:0048523) 1.413PTPN11, BRAF, RAF1
positive regulation of cellular process (GO:0048522) 1.33PTPN11, BRAF, RAF1
regulation of immune response (GO:0050776) 2.982PTPN11, RAF1
cellular component assembly (GO:0022607) 2.142BRAF, RAF1
positive regulation of peptidyl-serine phosphorylation (GO:0033138) 5.262BRAF, RAF1
regulation of cellular localization (GO:0060341) 3.032PTPN11, BRAF
activation of MAPKK activity (GO:0000186) 5.742BRAF, RAF1
negative regulation of secretion (GO:0051048) 4.442PTPN11, BRAF
regulation of transport (GO:0051049) 2.242PTPN11, BRAF
regulation of cell adhesion (GO:0030155) 3.272PTPN11, BRAF
carbohydrate homeostasis (GO:0033500) 4.62PTPN11, RAF1
homeostatic process (GO:0042592) 2.612PTPN11, RAF1
glucose homeostasis (GO:0042593) 4.62PTPN11, RAF1
positive regulation of gene expression (GO:0010628) 2.352BRAF, RAF1
negative regulation of secretion by cell (GO:1903531) 4.552PTPN11, BRAF
regulation of secretion by cell (GO:1903530) 3.282PTPN11, BRAF
cell surface receptor signaling pathway (GO:0007166) 2.092PTPN11, RAF1
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242PTPN11, RAF1
regulation of cell differentiation (GO:0045595) 2.422BRAF, RAF1
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542PTPN11, RAF1
anatomical structure morphogenesis (GO:0009653) 2.532PTPN11, BRAF
regulation of apoptotic process (GO:0042981) 2.52BRAF, RAF1
regulation of defense response (GO:0031347) 3.112PTPN11, RAF1
cellular response to stimulus (GO:0051716) 1.972PTPN11, BRAF
regulation of cell death (GO:0010941) 2.432BRAF, RAF1
regulation of secretion (GO:0051046) 3.22PTPN11, BRAF
protein complex subunit organization (GO:0071822) 2.62BRAF, RAF1
positive regulation of cell adhesion (GO:0045785) 3.792PTPN11, BRAF
MAPK cascade (GO:0000165) 3.912BRAF, RAF1
regulation of programmed cell death (GO:0043067) 2.492BRAF, RAF1
macromolecular complex assembly (GO:0065003) 2.552BRAF, RAF1
macromolecular complex subunit organization (GO:0043933) 2.142BRAF, RAF1
positive regulation of immune system process (GO:0002684) 2.962PTPN11, RAF1
negative regulation of apoptotic process (GO:0043066) 3.042BRAF, RAF1
regulation of immune system process (GO:0002682) 2.52PTPN11, RAF1
signal transduction by protein phosphorylation (GO:0023014) 3.792BRAF, RAF1
thymus development (GO:0048538) 5.882BRAF, RAF1
regulation of peptidyl-serine phosphorylation (GO:0033135) 4.982BRAF, RAF1
hematopoietic or lymphoid organ development (GO:0048534) 4.492BRAF, RAF1
negative regulation of programmed cell death (GO:0043069) 3.022BRAF, RAF1
regulation of gene expression (GO:0010468) 1.372BRAF, RAF1
regulation of cell proliferation (GO:0042127) 2.412BRAF, RAF1
protein phosphorylation (GO:0006468) 2.892BRAF, RAF1
transport (GO:0006810) 1.512BRAF, RAF1
neurotrophin signaling pathway (GO:0038179) 6.552PTPN11, RAF1
regulation of innate immune response (GO:0045088) 3.862PTPN11, RAF1
negative regulation of transport (GO:0051051) 3.62PTPN11, BRAF
stem cell population maintenance (GO:0019827) 4.832BRAF, RAF1
regulation of developmental process (GO:0050793) 2.12PTPN11, BRAF
negative regulation of cell death (GO:0060548) 2.952BRAF, RAF1
protein complex assembly (GO:0006461) 2.782BRAF, RAF1
regulation of hormone levels (GO:0010817) 3.562PTPN11, RAF1
establishment of protein localization (GO:0045184) 2.532BRAF, RAF1
maintenance of cell number (GO:0098727) 4.822BRAF, RAF1
single-organism transport (GO:0044765) 2.182BRAF, RAF1
regulation of locomotion (GO:0040012) 3.122BRAF, RAF1
regulation of multicellular organismal process (GO:0051239) 1.872PTPN11, BRAF
somatic stem cell population maintenance (GO:0035019) 5.522BRAF, RAF1
regulation of protein complex assembly (GO:0043254) 3.832PTPN11, RAF1
establishment of localization (GO:0051234) 1.482BRAF, RAF1
localization (GO:0051179) 1.42BRAF, RAF1
single-organism localization (GO:1902578) 2.092BRAF, RAF1
response to abiotic stimulus (GO:0009628) 2.82BRAF, RAF1
heart development (GO:0007507) 4.242PTPN11, RAF1
regulation of cellular component movement (GO:0051270) 3.082BRAF, RAF1
organic substance transport (GO:0071702) 2.152BRAF, RAF1
thyroid gland development (GO:0030878) 6.472BRAF, RAF1
neurotrophin TRK receptor signaling pathway (GO:0048011) 6.962PTPN11, RAF1
response to stress (GO:0006950) 1.82PTPN11, RAF1
chemical homeostasis (GO:0048878) 2.972PTPN11, RAF1
regulation of cell motility (GO:2000145) 3.162BRAF, RAF1
gland development (GO:0048732) 4.152BRAF, RAF1
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562PTPN11, BRAF
platelet activation (GO:0030168) 4.962PTPN11, RAF1
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232PTPN11, BRAF
face development (GO:0060324) 6.782BRAF, RAF1

NET-GE enrichment

Term New enriched termICP valueGenes
activation of MAPKK activity (GO:0000186) -5.740.016BRAF, RAF1
positive regulation of peptidyl-serine phosphorylation (GO:0033138) -5.260.002PTPN11, BRAF, RAF1
positive regulation of kinase activity (GO:0033674) -3.540.009PTPN11, BRAF, RAF1
regulation of peptidyl-serine phosphorylation (GO:0033135) -4.980.004PTPN11, BRAF, RAF1
activation of protein kinase activity (GO:0032147) -4.080.001PTPN11, BRAF, RAF1
response to growth factor (GO:0070848) NEW4.140.015PTPN11, BRAF, RAF1
somatic stem cell maintenance (GO:0035019) -5.520.008BRAF, RAF1
negative regulation of cell adhesion (GO:0007162) NEW4.330.012PTPN11, BRAF, RAF1
regulation of neuron apoptotic process (GO:0043523) NEW4.470.049PTPN11, BRAF, RAF1
negative regulation of neuron apoptotic process (GO:0043524) NEW4.820.012PTPN11, BRAF, RAF1
enzyme linked receptor protein signaling pathway (GO:0007167) -3.240.034PTPN11, BRAF, RAF1
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) -3.540.014PTPN11, BRAF, RAF1
fibroblast growth factor receptor signaling pathway (GO:0008543) NEW5.30.0PTPN11, BRAF, RAF1
Ras protein signal transduction (GO:0007265) NEW4.760.015PTPN11, BRAF, RAF1
negative regulation of MAPK cascade (GO:0043409) NEW4.740.01PTPN11, BRAF, RAF1
regulation of MAPK cascade (GO:0043408) -3.220.012PTPN11, BRAF, RAF1
cellular polysaccharide metabolic process (GO:0044264) NEW5.410.001PTPN11, BRAF, RAF1
cellular carbohydrate metabolic process (GO:0044262) NEW4.740.011PTPN11, BRAF, RAF1
response to nitrogen compound (GO:1901698) NEW3.120.032PTPN11, BRAF, RAF1
regulation of kinase activity (GO:0043549) -3.070.032PTPN11, BRAF, RAF1
MAPK cascade (GO:0000165) -3.910.022PTPN11, BRAF, RAF1
cellular response to fibroblast growth factor stimulus (GO:0044344) NEW6.40.0PTPN11, BRAF, RAF1
energy reserve metabolic process (GO:0006112) NEW5.440.013PTPN11, BRAF, RAF1
signal transduction by phosphorylation (GO:0023014) -3.790.038PTPN11, BRAF, RAF1
cellular glucan metabolic process (GO:0006073) NEW5.650.0PTPN11, BRAF, RAF1
neurotrophin signaling pathway (GO:0038179) -6.550.002PTPN11, BRAF, RAF1
regulation of protein kinase activity (GO:0045859) -3.150.027PTPN11, BRAF, RAF1
positive regulation of neuron projection development (GO:0010976) NEW4.260.004PTPN11, BRAF, RAF1
neurotrophin TRK receptor signaling pathway (GO:0048011) -6.960.002PTPN11, BRAF, RAF1
positive regulation of transferase activity (GO:0051347) -3.310.015PTPN11, BRAF, RAF1
response to peptide hormone (GO:0043434) NEW4.060.004PTPN11, BRAF, RAF1
negative regulation of neuron death (GO:1901215) NEW4.570.018PTPN11, BRAF, RAF1
platelet activation (GO:0030168) -4.960.033PTPN11, BRAF, RAF1
glucan metabolic process (GO:0044042) NEW5.650.0PTPN11, BRAF, RAF1
positive regulation of phosphorylation (GO:0042327) -2.90.036PTPN11, BRAF, RAF1
cellular response to growth factor stimulus (GO:0071363) NEW4.270.014PTPN11, BRAF, RAF1
energy derivation by oxidation of organic compounds (GO:0015980) NEW4.930.03PTPN11, BRAF, RAF1
glycogen metabolic process (GO:0005977) NEW5.670.0PTPN11, BRAF, RAF1
polysaccharide metabolic process (GO:0005976) NEW5.320.001PTPN11, BRAF, RAF1
response to hormone (GO:0009725) NEW3.330.037PTPN11, BRAF, RAF1
response to organonitrogen compound (GO:0010243) NEW3.20.025PTPN11, BRAF, RAF1
positive regulation of protein modification process (GO:0031401) -2.70.049PTPN11, BRAF, RAF1
regulation of transferase activity (GO:0051338) -2.880.048PTPN11, BRAF, RAF1
response to peptide (GO:1901652) NEW3.940.004PTPN11, BRAF, RAF1
response to fibroblast growth factor (GO:0071774) NEW6.170.001PTPN11, BRAF, RAF1
positive regulation of protein kinase activity (GO:0045860) -3.610.007PTPN11, BRAF, RAF1
response to wounding (GO:0009611) NEW4.390.037PTPN11, BRAF, RAF1
positive regulation of protein phosphorylation (GO:0001934) -2.950.023PTPN11, BRAF, RAF1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.013PTPN11, BRAF, RAF1
cytosol (GO:0005829) 1.683PTPN11, BRAF, RAF1
intracellular membrane-bounded organelle (GO:0043231) 0.63PTPN11, BRAF, RAF1
nucleus (GO:0005634) 1.073PTPN11, BRAF, RAF1
cell part (GO:0044464) 0.113PTPN11, BRAF, RAF1
cytoplasmic part (GO:0044444) 0.823PTPN11, BRAF, RAF1
mitochondrion (GO:0005739) 2.423PTPN11, BRAF, RAF1
intracellular organelle (GO:0043229) 0.513PTPN11, BRAF, RAF1
intracellular part (GO:0044424) 0.283PTPN11, BRAF, RAF1
membrane-bounded organelle (GO:0043227) 0.473PTPN11, BRAF, RAF1
organelle (GO:0043226) 0.43PTPN11, BRAF, RAF1
cell projection (GO:0042995) 2.472BRAF, RAF1
membrane (GO:0016020) 0.682BRAF, RAF1
plasma membrane (GO:0005886) 1.392BRAF, RAF1

NET-GE enrichment

Term New enriched termICP valueGenes
protein kinase complex (GO:1902911) NEW5.310.025BRAF, RAF1
anchoring junction (GO:0070161) NEW3.610.026PTPN11, BRAF, RAF1
adherens junction (GO:0005912) NEW3.660.023PTPN11, BRAF, RAF1
transferase complex (GO:1990234) NEW3.320.037PTPN11, BRAF, RAF1
cell-substrate adherens junction (GO:0005924) NEW3.830.014PTPN11, BRAF, RAF1
focal adhesion (GO:0005925) NEW3.830.013PTPN11, BRAF, RAF1
cell-substrate junction (GO:0030055) NEW3.820.015PTPN11, BRAF, RAF1