Disease table of MELANOMA, CUTANEOUS MALIGNANT OMIM ID: PS155600

Gene-disease associations table

GeneAssociated with MELANOMA, CUTANEOUS MALIGNANT inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MC1RClinVar, OMIM, HUMSAVARHGNC link16q24.34PS227220, 613098, PS155600, PS203100
CDKN2AClinVar, OMIM, HUMSAVARHGNC link9p21.34PS151623, PS155600, 606719, 155755
STK11ClinVar, OMIMHGNC link19p13.34175200, 273300, PS155600, 260350
POT1ClinVar, OMIM, HUMSAVARHGNC link7q31.332PS137800, PS155600
PTENOMIMHGNC link10q23.3110276950, 608089, 275355, 176807, PS155600, PS137800, 605309, 607174, 153480, PS158350
CDK4ClinVar, OMIM, HUMSAVARHGNC link12q14.11PS155600
BRAFOMIMHGNC link7q348605027, PS115150, PS151100, PS155600, 211980, PS188550, PS163950, 114500
MITFClinVar, OMIM, HUMSAVARHGNC link3p133103500, PS155600, PS193500
XRCC3ClinVar, OMIM, HUMSAVARHGNC link14q32.332PS155600, 114480
TERTClinVar, OMIMHGNC link5p15.335PS127550, 601626, 178500, PS155600, PS614742
TYRClinVarHGNC link11q14.34PS193500, PS227220, PS155600, PS203100

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
7q32POT1, BRAF
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
7q2POT1, BRAF
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
72POT1, BRAF
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
MITFYES27BEST1, MET, MC1R, TYR, BCL2A1, TRAP, FOS, DCT, BIRC7, TRPM1, CD82, ITGA4, PPARGC1A, KIT, GPNMB, MLANA, KCNMA1, OCA2, PMEL, HOXB4, CDK2, PRKCB, TYRP1, CTSK, HIF1A, ACP5, SERPINF12MC1R, TYR
HDAC1NO64NFYA, PSIP1, RECK, EIF2AK1, RARB, BIRC3, IGFBP3, CD1D, HSPA5, FOS, CDKN2A, TXNIP, PTGS2, RUNX3, NOS3, RHOB, MICA, EGR1, FAS, KLF4, CLDN7, HMGCS1, CD44, CCND2, MICB, CD82, RECQL4, GRIN2B, SP1, SERPINB5, PHB, BIRC5, COMP, CDC25A, ESR1, FSHR, HOXA9, AR, GAD1, RELN, KLK3, CDH1, SPP1, TP53, PCNA, CXCL8, ICAM1, MGMT, TFF1, EPCAM, STAT3, BRCA2, ABCB1, BCL2A1, SNAI2, HLA-DRA, CDKN1A, MMP28, MMP9, TJP1, TERT, IL2, CCND1, CDKN1B2CDKN2A, TERT
MXD1NO3ODC1, TERT, PTEN2TERT, PTEN
STAT3NO129IFNG, MMP2, CCND3, EGFR, GAST, VEGFA, CHI3L1, CYP19A1, HAMP, POU2F1, COPS5, SLC9A3, IL11, SAA1, F2R, HP, IL10, PIAS3, CDK4, AKT1, CXCL8, OAS1, IL2, LTBP1, PTPN6, TP63, FAAH, MMP9, FLT3, JUNB, ZFP36, BCL2L1, CCL11, FGF1, TWIST2, JAK2, CFLAR, NR0B1, FGF2, MMP7, PTGS2, CCND2, MCL1, UCP2, SOCS3, CFB, HSPB1, HGF, NOX5, NOSTRIN, ESR2, CISH, IKBKE, JAK3, MMP1, CDH1, TIMP1, CYR61, CCL20, CRP, CD46, TRH, IRF1, TERT, ETV6, HIF1A, NANOG, NME1, TYK2, OPRM1, MDC1, A2M, FOS, PHB, IL2RA, OSM, MUC4, CCND1, NDUFA13, SOCS1, MMP14, SHH, IFNAR1, PRDM1, FGG, CSRP1, GFAP, TWIST1, PTEN, ICAM1, VEGFB, LEP, USP7, IL1RN, BST2, HMOX1, KRT17, MMP3, CDKN1B, PGF, MICA, TP53, DDIT3, BIRC5, FGL1, PIM1, MUC1, S1PR1, KLF11, FAS, STS, DNMT1, TGFB1, CDKN1A, VDR, TNFRSF10B, PAX3, LCAT, CTGF, BCL6, LGALS3BP, BCL2, HSPA4, IL21, SALL4, IL6, ROR1, MYC, AKAP123CDK4, TERT, PTEN
DNMT1NO24MBD2, BIRC5, IL32, CDKN2A, CDKN2B, TIMP3, CASP8, PROM1, CXCR4, BAG1, TERT, GAD1, TNFRSF10B, CDH1, VEGFA, RELN, EPCAM, MGMT, IL3, KIR2DL3, RUNX3, RB1, BMP2, MSH22CDKN2A, TERT
ETS2NO35CDK1, MDM2, PDE7A, TP53, CSF2, MMP2, MMP9, FLI1, MSR1, CDKN2A, IL12B, ANGPT2, APP, EGR1, TAL1, ERG, CHRNE, CDKN1A, LCK, SPP1, CD163, TLR9, VWF, ICAM1, CGA, ANPEP, TNC, CXCL8, MMP3, DUSP6, MMP1, CSF3R, IL5, TERT, MYC2CDKN2A, TERT
ETS1NO90PF4, ITGB3, TP53, TBXAS1, GABRE, PTHLH, TNFSF14, CD14, IGFBP1, BAX, SLC26A3, IL2, MGAT5, VWF, HPGD, CA9, MMP3, MMP9, CSF3R, IL2RB, TERT, THY1, FLT1, FGFBP1, CSF2, MYB, FLI1, ANGPT2, GP6, EGR1, TMEM158, CSNK2B, ERG, SQSTM1, WAS, F13A1, CD8A, MMP1, TGFBR2, ABCB1, ATXN2, NDRG1, SPRY2, HSPB8, BMP4, PRL, TBXA2R, CDKN2A, CHUK, NKX3-1, TAF12, MUC4, HSPE1, TRB, AXIN1, BRCA1, LCK, MMP10, SPP1, RHOC, ICAM1, ANPEP, CSNK2A1, IL5, CR1, HSPA6, HMOX1, CASP1, MDM2, PLAU, SNAI1, TFAP2A, CTSB, TRA, CXCR4, ECE1, SRD5A1, HSPA1L, DUSP6, CDKN1A, FOXD1, GRPR, CTGF, PARP1, TNC, HSPA8, IL3, COL1A1, MMP13, CD62CDKN2A, TERT
NFKB1NO306NRF1, VWF, FTH1, PGLYRP2, CDK4, RGS4, IFNG, MMP2, DCST1, AGT, THBD, EGFR, GDNF, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, HOXA9, IRF7, TNC, AGER, EDN1, HBEGF, SFTPA1, SAA1, TSLP, GSK3A, IFNB1, GKN2, TRAF2, PLA2G2A, F3, IL10, LIPE, FAF1, IL17A, CEACAM1, AKT1, KLK3, IL1RN, GSTP1, E2F1, CCR5, TAPBP, ADORA2A, CXCL1, PTPN6, MMP3, PIGR, ERAP1, YY1, OLFM4, DEFB4A, CCL2, CD28, SQSTM1, TERT, IL4, NAMPT, BACE1, JUNB, SLC9A2, FASLG, ALOX5, BCL2L1, CD83, TLR3, CCL22, PLIN1, CDKN1A, BIRC3, CSF2, CFLAR, TFPI2, MYB, IL18, SERPINB1, MUC17, TNFRSF10A, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, CD3G, TFF1, B2M, PLAU, TNF, FOXP3, HDAC7, MUC5B, CCR2, FIGF, HSD11B2, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, MUC2, TIMP1, CCL19, FGF8, PDK4, CCL20, STK39, CYP3A7, MMP9, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PSMB9, PTEN, HPSE, CCNB1, CD40, NOS3, PTGDS, UPP1, HIF1A, TNFRSF9, CD80, TNFSF13B, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, OPRM1, HLA-F, AMH, XIAP, MADCAM1, HYAL1, A2M, CCL11, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, CTCF, ABCB1, GSK3B, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, IL17C, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, CREB3, CXCL2, CRP, KDM2A, BCL2A1, BRCA2, IKBKB, GFAP, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, S100A6, DRD2, CXCL8, CD86, TRAF1, PTPN13, CSNK2A1, CARD8, CXCL10, IL6, CFTR, CASP9, ABCG2, BMP2, CRMP1, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, NCOR1, SNAI1, BAX, NPPB, CTSB, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, NOD2, CCL5, FAS, ALOX5AP, OLR1, CXCR4, SDC1, FLT4, NCOR2, AKT2, CDH1, TGFB1, CCL3, IGF2BP2, HDAC1, SP1, PDE7A, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, HAX1, CYP27B1, NLRP2, FGF7, PTGER4, TNFRSF13C, CARM1, EBI3, VCAM1, ERAP2, MYC, CSF1, EPCAM, SLC25A27, NOS2, RIPK2, EGR1, BTG2, BCL2, ABCA1, CD69, BIRC2, CCR3, IL21, GCLC, MMP13, GRIN1, SP3, RRM2B, STAT4, TF, MUC63CDK4, TERT, PTEN
RELANO302NRF1, OXTR, FTH1, CDK4, UPP1, IFNG, MMP2, DCST1, AGT, FLT4, EGFR, CCL4, NCAM1, VEGFA, CR2, CFI, TP53, FOXO3, CYP19A1, BGN, LPL, CXCL12, ELF3, PTHLH, IRF7, TNC, AGER, EDN1, SFTPA1, IGF2BP2, PPARA, SAA1, TSLP, GSK3A, IFNB1, GKN2, PLA2G2A, F3, IL10, KLK3, MMP12, IL17A, NR4A1, CEACAM1, AKT1, EPAS1, IL1RN, BAX, TRIB3, E2F1, PCK2, CXCL1, PTPN6, MMP3, CDK6, PIGR, ERAP1, YY1, OLFM4, IL18, LIPE, CD28, MMP9, TERT, IL4, NAMPT, BACE1, JUNB, CCR2, FASLG, ALOX5, BCL2L1, CCL11, PGR, GTF2B, CCL22, PLIN1, AKT2, BIRC3, HBEGF, CCL2, SERPINB1, MUC17, BAD, FGF7, PTGFR, TFF3, PTAFR, PTGS2, COX1, SERPINA3, ITGAX, CCND2, MCL1, TLR7, POU2F2, REPS2, TF, TFF1, SLC9A2, PLAU, TNF, FOXP3, HDAC7, MUC5B, NCOR1, FIGF, CYP3A4, SP1, CCL13, IFNA1, NOX5, MAT2A, COL7A1, HMOX1, ADORA1, TNFSF10, AR, CCR5, COL2A1, TAP1, IL1B, CD74, CD38, MUC5AC, GSTP1, MUC2, TIMP1, CCL19, CXCR4, FGF8, PDK4, CCL20, STK39, CYP3A7, GATA3, IRF4, CD58, HES1, PLAUR, SP4, NFKB1, MMP1, NOX4, BDKRB1, CASP3, CYP1A1, PTEN, HPSE, CCNB1, CD40, NOS3, ABCA1, PPARD, HIF1A, TNFRSF9, CD80, KDM2A, IL23A, TNFAIP3, TNFSF14, IL12A, TRPC1, CYP2E1, RGS4, ADORA2A, AMH, XIAP, MADCAM1, HYAL1, CFLAR, TBX21, ICAM1, BCL2L11, CHUK, TAP2, IL2RA, TLR3, ABCB1, IL17C, CCND1, KLF5, CCR7, CCK, DCST2, MMP14, FBP1, OPTN, IL1A, LTC4S, COL1A2, NOS1, WT1, BIRC5, PPIG, PTGES, THBD, CREB3, VWF, CXCL2, CRP, HLA-A, BCL2A1, BRCA2, IKBKB, GFAP, TWIST1, PSMB10, PROX1, COL1A1, TNIP3, NFKBIZ, TLR2, TNFRSF10A, S100A6, DRD2, CXCL8, BTG2, TRAF1, PTPN13, CD83, CSNK2A1, CARD8, CXCL10, CDKN1A, IL6, CFTR, CASP9, SIRT1, BMP2, IL2, IRF1, SOD2, IER3, NFKBIA, FN1, SERPINE1, MICA, TBP, CXCR2, BHMT, ABCG2, SNAI1, NOS2, PSMB9, CTSB, HSD11B2, F8, IL12B, IGF2BP1, LCN2, NOLC1, CD40LG, SELE, CCL5, FAS, ALOX5AP, OLR1, VCAM1, SDC1, SAA2, NCOR2, DEFB4A, CDH1, TRAF2, CCL3, GNRH2, HDAC1, TAPBP, CSF2, ADORA3, CRHR1, BCL3, MIF, CXCL5, TNFRSF10B, CYP27B1, NLRP2, FAF1, PTGER4, TNFRSF13C, CARM1, EBI3, ERAP2, CSF1, EPCAM, SLC25A27, RIPK2, EGR1, CD86, BCL2, CD69, BIRC2, CCR3, NPPB, GCLC, MMP13, GRIN1, SP3, MYC, STAT4, MUC63CDK4, TERT, PTEN
MTA1NO20EPHA2, NOS2, MMP9, EGFR, MNAT1, MTA3, SNAI1, SMAD7, BCL2L1, CDH1, MYC, CDKN1A, SNAI2, PTEN, ITGB3BP, ESR1, CDKN2A, SUMO2, BRCA1, TFF12CDKN2A, PTEN
TCF4NO21MITF, MYC, BIRC5, ABCB1, LGR5, DEFA6, PLD1, JUN, NOTUM, NRXN1, CLEC4C, VIM, VCAN, PTEN, DEFA5, CNTNAP2, COPS5, VEGFA, KLF4, CCND1, WNT42PTEN, MITF
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC15TERT, CDKN2A, STK11, CDK4, PTEN
MYCNO102CBFB, PRDX3, CHKA, ATF3, CDK4, PCNA, CEBPA, LDHA, DKK1, MTDH, TFAP4, HLA-G, CDC25A, UBE2C, HLA-B, GATA1, TP53, BAG2, PMAIP1, CDK6, WRN, PGK1, TFAM, IGK, JUNB, ZFP36, HNRNPA1, MYB, SART3, EBNA1BP2, TOP1MT, ST3GAL4, CD33, CCND2, PTBP1, CDCA7, RB1, CCNA2, HLA-C, CYP3A4, FMR1, TERT, NFE2, MME, NDRG1, HDAC2, BRD7, FASLG, CCNB1, TP73, RCC1, SFRP1, HLA-F, CFLAR, BCAT1, CD38, TFRC, CCND1, MTA1, KRAS, HNRNPA2B1, CDC34, ST3GAL3, HLA-A, FUT3, NOL7, FTH1P18, VEGFA, EP300, CDK2, ASS1, SURF1, CDC25C, IER3, ST3GAL1, FOXM1, HSPA4, XPO1, CAD, SHMT1, DDX18, IGF2BP1, BMI1, IPO7, BCL2, CXCR4, SRSF1, TLX1, PRODH, NBN, CDKN1A, IFNA1, TNFRSF10B, ID2, CCNE1, SURF2, HLA-E, CREBBP, MAPK1, IL6, EIF4E, ODC12CDK4, TERT
TP53NO159ATF3, AKT1, UHRF1BP1, TP53, CAV1, EGFR, ALKBH2, PAX5, PRG3, PDGFRB, VCAN, MAD1L1, CTNNB1, ID1, TCEAL1, ESR1, CABLES1, MKI67, BAX, SLC6A6, PERP, MAP4, RASSF1, PIAS3, CDK4, RELA, CYFIP2, SSTR2, PMAIP1, BRCA2, WRN, PTTG1, TBXAS1, BTG3, EZH2, SFN, ANKRD1, REEP5, MYC, BCL2L1, GDF15, MCM7, IGFBP3, BGLAP, GC, HSP90AB1, FGF2, CCNB2, PRKAB1, CARM1, EGR1, THBS1, RB1, DDB1, CCNA2, IFI16, BAI1, OGG1, MCL1, GPNMB, MUC2, TRIM22, GSTP1, RAD51B, AQP3, TYMS, TNFRSF10A, GML, TERT, FDXR, GADD45A, S100B, CDKN1B, CCNB1, CHEK2, BCL3, NME1, PRC1, SIAH1, SLC2A1, MMP1, E2F7, CHUK, POLD1, NKX3-1, RECQL4, ABCB1, CCND1, E2F3, TP53I3, SMAD3, DDB2, BRCA1, HIPK2, BIRC5, DKK1, HRAS, NLRC4, PTEN, VEGFA, FOXO3, ANTXR1, MGMT, FOXM1, UHRF1, CDK2, HR, CHEK1, TCF7L2, ALOX5, APAF1, MDM4, AFP, IGF1R, HNF4A, IER3, CDK1, CASP1, BDKRB2, MDM2, MET, CRYAB, XPO1, MMP2, PTPN13, IPO7, CASP3, ELF4, HSF1, FLT1, FAS, PML, GLI2, EPHA2, DNMT1, CD82, E2F1, CDKN1A, SIVA1, BBC3, PLAGL1, TNFRSF10B, CTSD, ID2, CKM, XPC, NFKB1, TP73, DUSP1, STAT3, BCL2, BTG2, PLK3, CCNA1, PPP2R4, KLF2, APCS, RRM2B, ING13CDK4, TERT, PTEN
E2F1NO123WWOX, DOK1, MEFV, MYBL2, MCM8, FZD1, DIRAS3, PIN1, PCNA, DHFR, ETV4, LRBA, RPA2, FSHR, SERPINB5, PCSK6, TP53, FOXM1, E2F1, IL23A, CD2AP, HMGA1, XRCC1, FHIT, IRF3, ATM, MYC, MT1G, NRIP1, FLT1, RRP1B, MYB, SERPINE1, BMI1, CDKN2A, SKP2, MAPK8, CCNE1, CASP7, CDCA7, HIC1, THBS1, RB1, TNF, IL1B, ULK1, ERCC1, CUX1, TERT, MCL1, AR, KIR3DL1, NPAT, PDK4, DDB2, E2F6, ABCB1, BBC3, AURKA, NOX4, MYCN, CCNB1, TP73, FGFR1, RRM1, RRM2, HSPA5, TLR3, MUC4, CCND1, MCPH1, BRCA1, DRAM1, ERCC5, BIRC5, TYMS, RASGEF1B, MAP1LC3A, VEGFA, RACGAP1, FANCA, UHRF1, CHEK1, MCM5, RASGRP1, APAF1, ISYNA1, ECT2, TNFSF11, AURKB, CDK1, MDM2, DDIT3, MAP3K5, DBF4, PNRC2, KIF2C, POLA1, CTNNBIP1, ELF4, KDR, TP53INP1, ATAD2, CCL3, TK1, ATG5, CDKN1A, SIVA1, PEG10, TOP2A, CDAN1, CHEK2, DUSP1, ASF1B, DAPK2, PTPRO, BCL2, CREBBP, TP53BP2, GINS3, MYH10, PPARG, PPP1R13B2CDKN2A, TERT
ESR1NO68UGT2B15, AR, PELP1, EGFR, FLT1, RET, AVP, NRF1, CDK4, SERPINE1, PGR, FOS, VEGFA, CHAT, RUNX2, ZFHX3, CYP19A1, SERPINB9, TYMS, DCT, CXCL12, PTMA, HTRA2, NR5A2, CD24, HSPB1, CYP1B1, CTNNB1, MMP13, BRCA1, CYP2C19, BLM, OXT, TAC3, CCNA2, ZEB1, CDKN1A, STAT5A, TERT, MDM2, PMAIP1, CYP1A1, RARA, TP53, JUN, CDH1, AMH, CRHBP, MYC, TFF1, E2F1, CRH, KDR, BTG2, BCL2, UGT1A4, TGFA, KRT19, F12, FOXP1, ESRRA, GREB1, CTSD, JUNB, ESR1, YWHAQ, CCND1, CDKN1B2CDK4, TERT
SOX9NO25SF1, AR, COL11A2, RET, RXFP2, NR5A1, CDK4, BEST1, DCT, TYR, COL2A1, KLF4, MIA, DCC, PRAME, SOX10, CDKN1A, NES, HES1, CEACAM1, MITF, AMH, SHH, POU3F2, ETV23TYR, CDK4, MITF
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
MC1RYES1MITF1MITF
CDKN2AYES24FOXM1, EAPP, ETS2, EZH2, DNMT3A, HDAC9, ZBTB7A, SP1, HDAC3, MTA1, DNMT1, TBX2, E2F1, SMARCB1, TBX3, ZNF148, HDAC1, HDAC4, ETS1, SMARCA1, TBX5, SMARCA4, SP3, JUNB0
STK11YES4SP1, NFYB, NFYA, NR1H40
PTENYES15SP1, STAT3, EGR1, TCF4, NFKB1, MTA1, AR, TP53, HES1, TFAP2A, RELA, RBPJ, MXD1, PPARG, SRF0
CDK4YES12SP1, STAT3, SOX9, NR3C1, IRF1, RELA, TP53, SATB1, ESR1, MYC, NFKB1, SOX60
MITFYES14FOXD3, LEF1, SOX9, TCF4, POU3F2, ATF1, TRRAP, CREB1, ONECUT2, ONECUT1, PIAS3, PAX3, ZNF382, SOX100
TERTYES30CTCF, MZF1, ETS2, MXD1, USF2, SP1, ID2, TAL1, SMAD3, DNMT1, E2F1, WT1, ESR2, HDAC1, JUN, TP53, RELA, NFKB1, TP73, ETS1, HIF1A, STAT3, MEN1, NFATC2, FLI1, USF1, ESR1, MYC, PITX1, MYCN0
TYRYES4TFEB, OTX2, SOX9, MITF1MITF
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MC1RPOT1No1AHCY
CDKN2ASTK11No6NAT2, TP63, HSP90AA1, TUBA1A, TP53, SMARCA4
CDKN2APOT1No7TUBB4B, MDM2, GAPDH, SERTAD1, ACTB, HSP90AB1, ACTN4
CDKN2APTENNo13HSP90AA1, TUBB4B, HSPA8, MYO1C, EGR1, MYL12A, TUBA1C, TUBB, HNRNPU, TP53, HSP90AB1, UBE2I, EEF2
CDKN2ACDK4Yes21SP1, MYC, IQGAP1, CCND2, PCNA, SENP3, SAP25, CDC6, CCND1, RELA, CDK6, BAG6, SERTAD1, CDC7, COPS5, HSP90AA1, HSP90AB1, HSPA8, BRCA1, UCHL1, MCM2
CDKN2ABRAFNo5HSPA9, IQGAP1, HSPA8, HSP90AA1, HSP90AB1
CDKN2AMITFNo2UBE2I, PIAS2
CDKN2AXRCC3No3HNRNPA2B1, MTR, HSP90AB1
CDKN2ATERTNo6RUVBL2, MDM2, HSPA4, HSP90AA1, RELA, NCL
STK11POT1No3HSPA1A, CFL2, STUB1
STK11PTENNo5TP53, HSPA1A, EEF1A2, HSP90AA1, STUB1
STK11CDK4No4FKBP5, CDC37, HSP90AA1, APP
STK11BRAFNo3HSPA1A, CDC37, HSP90AA1
STK11MITFNo2APP, STUB1
STK11XRCC3No5FKBP5, TRIM25, BCAS3, SERPINB5, APP
STK11TERTNo4HSPA1A, RPS6KB1, HSP90AA1, STUB1
POT1PTENNo16TUBB4B, TUBB2A, RPS6, SPTAN1, S100A8, ANXA2, HSPA1A, TNKS, CFL1, MVP, HSP90AB1, LDHB, RPS2, STIP1, STUB1, DBN1
POT1CDK4No3SERTAD1, DBNL, HSP90AB1
POT1BRAFNo5YWHAG, HSPA1A, TERF1, YWHAE, HSP90AB1
POT1MITFNo1STUB1
POT1XRCC3No2STIP1, HSP90AB1
POT1TERTYes8HSPA1A, MDM2, POT1, ANXA2, TERF1, TPP1, STUB1, XRCC6
PTENCDK4No8COPS6, HSPA8, SKP1, PPP1CA, SMTN, PKM, HSP90AA1, HSP90AB1
PTENBRAFNo5HSP90AA1, HSPA1A, HSPA8, AKT1, HSP90AB1
PTENMITFNo3UBE2I, ELAVL1, STUB1
PTENXRCC3No11PPP1R10, CXCL1, MYOF, STIP1, OSGIN1, PC, ATP5A1, DNAJA1, HSP90AB1, HSPD1, BAP1
PTENTERTNo7HSPA1A, ANXA2, HSP90AA1, DDB1, AKT1, TUBA1B, STUB1
CDK4BRAFNo5CDC37, IQGAP1, HSPA8, HSP90AA1, HSP90AB1
CDK4MITFNo1APP
CDK4XRCC3No4FKBP5, QARS, APP, HSP90AB1
CDK4TERTNo4ATP5B, CIB1, HSP90AA1, RELA
BRAFXRCC3No1HSP90AB1
BRAFTERTNo6HSPA1A, TERF1, HSP90AA1, AKT1, YWHAQ, YWHAZ
MITFXRCC3No2APP, XPO1
MITFTERTNo1STUB1
XRCC3TERTNo1UBR5

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
BRAFTERTNo1MUS81

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MC1RPTENNo-2TXN, ADM
MC1RCDK4No-1MITF
MC1RMITFYesactivation, binding1STAMBP
STK11PTENYesactivation, binding15CDKN1A, PHLPP1, TSC2, CCND1, PHLPP2, TP53, SMAD4, RPTOR, RETN, ESR1, SMARCA4, LEP, VEGFA, FOXO3, RAC3
STK11CDK4No-8CDKN1A, CDC37, CCND1, CCNG1, HSP90AA1, SMAD4, TP53, MYC
STK11BRAFNo-3PRKACA, CDC37, HSP90AA1
STK11MITFNo-5SMARCA4, IL6, SIRT1, CDKN1A, TP53
STK11XRCC3No-2ACACA, ACACB
STK11TERTNo-8STAT3, SMARCA4, CCND1, HSP90AA1, TP53, ESR1, MYC, SIRT1
POT1CDK4No-1HIST3H3
POT1TERTYesbinding4ACD, TPP1, TERF1, TNKS
PTENCDK4No-17SP1, CDKN1A, FOXM1, SUMO1, CDC6, CCND1, NOTCH1, TP53, ATF2, JUN, SMAD3, SMAD4, BMP2, UBC, BMI1, BIRC5, CDKN1B
PTENBRAFNo-3UBC, SPRY2, AKT1
PTENMITFNo-15CDKN1A, BCL2, SUMO1, TP53, RPS6KB1, IL8, SMAD3, CREB1, BMP2, ATF2, SMARCA4, UBE2I, FOS, MAPK14, IGF2BP1
PTENTERTNo-16SP1, CDKN1B, EGFR, AKT1, CCND1, JUN, TP53, UBC, RPS6KB1, SMAD3, MTOR, ESR1, SRC, FOS, SMARCA4, HIF1A
CDK4BRAFNo-5UBC, SFN, CDC37, HSP90AA1, HSP90AB1
CDK4MITFYesexpression, binding6CDKN1A, SUMO1, ATF2, SMAD3, TP53, BMP2
CDK4XRCC3No-6BRCA2, MLH1, BLM, RAD51, DMC1, RAD51C
CDK4TERTNo-18SP1, MYC, TAF12, SUPT3H, HDAC1, TAF10, RB1, SUPT7L, HSP90AA1, MAX, JUN, SMAD3, TP53, ABL1, UBC, E2F1, CCND1, CDKN1B
BRAFMITFNo-3MAPK1, MAPK3, YWHAZ
BRAFTERTNo-6PRKCA, MAPK1, YWHAE, HSP90AA1, AKT1, UBC
BRAFTYRNo-1PRKCB
MITFTERTNo-10SMARCA4, LEF1, EP300, MAPK1, TP53, RPS6KB1, SMAD3, CTNNB1, FOS, SIRT1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
CDKN2ACDK4Yesp16-cyclin D2-CDK4 complex1CCND2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Melanomahsa052186.565CDK4, CDKN2A, PTEN, MITF, BRAF
Pathways in cancerhsa052003.985CDK4, CDKN2A, PTEN, MITF, BRAF
Gliomahsa052146.664CDKN2A, CDK4, PTEN, BRAF
Bladder cancerhsa052197.383CDKN2A, BRAF, CDK4
Pancreatic cancerhsa052126.563CDKN2A, BRAF, CDK4
p53 signaling pathwayhsa041156.563CDKN2A, CDK4, PTEN
Melanogenesishsa049165.973MC1R, TYR, MITF
FoxO signaling pathwayhsa040685.633BRAF, STK11, PTEN
Chronic myeloid leukemiahsa052206.483CDKN2A, BRAF, CDK4
Non-small cell lung cancerhsa052236.883CDKN2A, BRAF, CDK4
HTLV-I infectionhsa051664.593CDKN2A, TERT, CDK4
mTOR signaling pathwayhsa041506.723BRAF, STK11, PTEN
PI3K-Akt signaling pathwayhsa041514.213STK11, CDK4, PTEN
Endometrial cancerhsa052136.812BRAF, PTEN
Cell cyclehsa041105.682CDKN2A, CDK4
MicroRNAs in cancerhsa052065.382CDKN2A, PTEN
Viral carcinogenesishsa052035.082CDKN2A, CDK4
Prostate cancerhsa052156.112BRAF, PTEN
Tight junctionhsa045305.532CDK4, PTEN
Small cell lung cancerhsa052226.172CDK4, PTEN
Focal adhesionhsa045104.922BRAF, PTEN
Hepatitis Bhsa051615.522CDK4, PTEN

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) -6.560.0CDK4, CDKN2A, PTEN, MITF, BRAF
Bladder cancer (hsa05219) -7.380.0CDKN2A, BRAF, CDK4
Pancreatic cancer (hsa05212) -6.560.002CDKN2A, BRAF, CDK4
Infectious diseases: ViralNEW3.290.027CDK4, CDKN2A, TERT, PTEN, BRAF
MicroRNAs in cancer (hsa05206) -5.380.006CDKN2A, STK11, CDK4, PTEN
Pathways in cancer (hsa05200) -3.980.002CDK4, CDKN2A, PTEN, MITF, BRAF
Glioma (hsa05214) -6.660.0CDKN2A, CDK4, PTEN, BRAF
p53 signaling pathway (hsa04115) -6.560.002CDKN2A, CDK4, PTEN
Cancers: Specific typesNEW4.10.001CDK4, CDKN2A, PTEN, MITF, BRAF
Non-small cell lung cancer (hsa05223) -6.880.001CDKN2A, BRAF, CDK4
Endocrine systemNEW3.260.009TYR, MITF, POT1, MC1R, STK11, CDK4, PTEN, CDKN2A, BRAF
Chronic myeloid leukemia (hsa05220) -6.480.0CDKN2A, CDK4, PTEN, BRAF
Melanogenesis (hsa04916) -5.970.048MC1R, PTEN, TYR, MITF
HTLV-I infection (hsa05166) -4.590.02CDK4, CDKN2A, TERT, PTEN, MITF
Tyrosine metabolism (hsa00350) NEW7.640.02TYR, BRAF, POT1
Cell growth and deathNEW4.410.014CDK4, CDKN2A, STK11, PTEN, MITF
mTOR signaling pathway (hsa04150) -6.720.01BRAF, STK11, PTEN
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.785MC1R, PTEN, STK11, BRAF, TERT
Cell CycleR-HSA-16401703.894CDKN2A, POT1, TERT, CDK4
MetabolismR-HSA-14307282.343TYR, STK11, PTEN
Cellular responses to stressR-HSA-22627524.563CDKN2A, POT1, CDK4
Cellular SenescenceR-HSA-25595835.73CDKN2A, POT1, CDK4
Oncogene Induced SenescenceR-HSA-25595858.032CDKN2A, CDK4
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.852BRAF, STK11
Oxidative Stress Induced SenescenceR-HSA-25595806.512CDKN2A, CDK4
Senescence-Associated Secretory Phenotype (SASP)R-HSA-25595826.772CDKN2A, CDK4
Immune SystemR-HSA-1682562.372BRAF, PTEN
IGF1R signaling cascadeR-HSA-24289244.852BRAF, STK11
Downstream signal transductionR-HSA-1867634.652BRAF, PTEN
IRS-related events triggered by IGF1RR-HSA-24289284.852BRAF, STK11
Signaling by ERBB4R-HSA-12363944.72BRAF, PTEN
Signaling by Insulin receptorR-HSA-747524.732BRAF, STK11
Developmental BiologyR-HSA-12667383.482BRAF, CDK4
Insulin receptor signalling cascadeR-HSA-747514.852BRAF, STK11
Downstream signaling of activated FGFR1R-HSA-56546874.712BRAF, PTEN
Signalling by NGFR-HSA-1665204.232BRAF, PTEN
IRS-mediated signallingR-HSA-1123994.872BRAF, STK11
G1 PhaseR-HSA-692367.732CDKN2A, CDK4
Cell Cycle, MitoticR-HSA-692784.162CDKN2A, CDK4
Cyclin D associated events in G1R-HSA-692317.732CDKN2A, CDK4
Chromosome MaintenanceR-HSA-738866.562POT1, TERT
Downstream signaling of activated FGFR3R-HSA-56547084.712BRAF, PTEN
Signaling by FGFR4R-HSA-56547434.692BRAF, PTEN
Signaling by FGFR3R-HSA-56547414.692BRAF, PTEN
Mitotic G1-G1/S phasesR-HSA-4532795.912CDKN2A, CDK4
Signaling by FGFRR-HSA-1902364.672BRAF, PTEN
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.032BRAF, PTEN
Telomere MaintenanceR-HSA-1575797.12POT1, TERT
Innate Immune SystemR-HSA-1682493.172BRAF, PTEN
Signaling by SCF-KITR-HSA-14335574.732BRAF, PTEN
Signaling by PDGFR-HSA-1867974.532BRAF, PTEN
DAP12 signalingR-HSA-24244914.642BRAF, PTEN
Downstream signaling of activated FGFR2R-HSA-56546964.712BRAF, PTEN
Signaling by EGFRR-HSA-1779294.592BRAF, PTEN
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.512BRAF, PTEN
Signaling by GPCRR-HSA-3727902.682MC1R, BRAF
Signaling by FGFR2R-HSA-56547384.682BRAF, PTEN
Signaling by FGFR1R-HSA-56547364.692BRAF, PTEN
MeiosisR-HSA-15006206.592POT1, CDK4
DAP12 interactionsR-HSA-21721274.562BRAF, PTEN
Downstream signaling of activated FGFR4R-HSA-56547164.712BRAF, PTEN
Signaling by ERBB2R-HSA-12279864.662BRAF, PTEN

NET-GE enrichment

Term New enriched termICP valueGenes
Oncogene Induced Senescence (R-HSA-2559585) -8.030.001CDKN2A, CDK4
Oxidative Stress Induced Senescence (R-HSA-2559580) -6.510.023CDKN2A, CDK4
Cellular Senescence (R-HSA-2559583) -5.70.004CDKN2A, POT1, CDK4
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1811TYR, XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
protein binding (GO:0005515) 0.4611TYR, XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
catalytic activity (GO:0003824) 1.058TYR, PTEN, BRAF, STK11, TERT, CDK4, XRCC3, CDKN2A
heterocyclic compound binding (GO:1901363) 1.068XRCC3, POT1, BRAF, STK11, TERT, CDK4, MITF, CDKN2A
organic cyclic compound binding (GO:0097159) 1.058XRCC3, POT1, BRAF, STK11, TERT, CDK4, MITF, CDKN2A
cation binding (GO:0043169) 1.45TYR, BRAF, STK11, TERT, PTEN
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.775CDKN2A, STK11, CDK4, TERT, BRAF
enzyme binding (GO:0019899) 2.275MC1R, PTEN, CDKN2A, POT1, BRAF
ion binding (GO:0043167) 1.365TERT, BRAF, STK11, TYR, PTEN
transferase activity (GO:0016740) 1.955CDKN2A, STK11, TERT, CDK4, BRAF
nucleic acid binding (GO:0003676) 1.445POT1, CDKN2A, TERT, XRCC3, MITF
DNA binding (GO:0003677) 1.925CDKN2A, TERT, POT1, XRCC3, MITF
metal ion binding (GO:0046872) 1.415TYR, BRAF, STK11, TERT, PTEN
adenyl nucleotide binding (GO:0030554) 2.44BRAF, STK11, CDK4, XRCC3
carbohydrate derivative binding (GO:0097367) 2.034BRAF, STK11, CDK4, XRCC3
enzyme regulator activity (GO:0030234) 2.854CDKN2A, STK11, POT1, CDK4
kinase activity (GO:0016301) 2.934CDKN2A, STK11, BRAF, CDK4
purine ribonucleoside triphosphate binding (GO:0035639) 2.224BRAF, STK11, CDK4, XRCC3
nucleotide binding (GO:0000166) 1.964BRAF, STK11, CDK4, XRCC3
small molecule binding (GO:0036094) 1.894BRAF, STK11, CDK4, XRCC3
ribonucleotide binding (GO:0032553) 2.194BRAF, STK11, CDK4, XRCC3
identical protein binding (GO:0042802) 2.634TYR, BRAF, TERT, PTEN
adenyl ribonucleotide binding (GO:0032559) 2.414BRAF, STK11, CDK4, XRCC3
ATP binding (GO:0005524) 2.434BRAF, STK11, CDK4, XRCC3
purine nucleoside binding (GO:0001883) 2.224BRAF, STK11, CDK4, XRCC3
ribonucleoside binding (GO:0032549) 2.224BRAF, STK11, CDK4, XRCC3
purine ribonucleotide binding (GO:0032555) 2.24BRAF, STK11, CDK4, XRCC3
purine nucleotide binding (GO:0017076) 2.194BRAF, STK11, CDK4, XRCC3
protein dimerization activity (GO:0046983) 2.724TYR, BRAF, TERT, MITF
molecular function regulator (GO:0098772) 2.514CDKN2A, STK11, POT1, CDK4
purine ribonucleoside binding (GO:0032550) 2.224BRAF, STK11, CDK4, XRCC3
nucleoside phosphate binding (GO:1901265) 1.964BRAF, STK11, CDK4, XRCC3
nucleoside binding (GO:0001882) 2.214BRAF, STK11, CDK4, XRCC3
sequence-specific DNA binding (GO:0043565) 2.793POT1, TERT, MITF
kinase regulator activity (GO:0019207) 4.53CDKN2A, STK11, CDK4
protein kinase regulator activity (GO:0019887) 4.63CDKN2A, STK11, CDK4
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.083BRAF, STK11, CDK4
protein kinase binding (GO:0019901) 3.443CDKN2A, BRAF, PTEN
kinase binding (GO:0019900) 3.323CDKN2A, BRAF, PTEN
protein serine/threonine kinase activity (GO:0004674) 3.643BRAF, STK11, CDK4
protein kinase activity (GO:0004672) 3.273BRAF, STK11, CDK4
hydrolase activity (GO:0016787) 1.92XRCC3, PTEN
telomeric DNA binding (GO:0042162) 6.342POT1, TERT
transcription factor binding (GO:0008134) 3.462CDKN2A, TERT
magnesium ion binding (GO:0000287) 4.412STK11, PTEN
hydrolase activity, acting on ester bonds (GO:0016788) 3.12XRCC3, PTEN
single-stranded DNA binding (GO:0003697) 5.172POT1, XRCC3
cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538) 6.412CDKN2A, CDK4
macromolecular complex binding (GO:0044877) 2.612CDK4, PTEN
protein domain specific binding (GO:0019904) 3.322STK11, PTEN
signal transducer activity (GO:0004871) 2.282MC1R, BRAF
RNA binding (GO:0003723) 2.362CDKN2A, TERT
protein complex binding (GO:0032403) 3.092CDK4, PTEN
enzyme inhibitor activity (GO:0004857) 3.782CDKN2A, POT1
protein heterodimerization activity (GO:0046982) 3.642BRAF, TYR
p53 binding (GO:0002039) 5.532CDKN2A, STK11
double-stranded DNA binding (GO:0003690) 3.092XRCC3, MITF
protein homodimerization activity (GO:0042803) 3.162TYR, TERT

NET-GE enrichment

Term New enriched termICP valueGenes
kinase regulator activity (GO:0019207) -4.50.002POT1, CDKN2A, STK11, CDK4, PTEN
kinase activator activity (GO:0019209) NEW5.580.041STK11, POT1, PTEN
enzyme binding (GO:0019899) -2.270.043MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
enzyme inhibitor activity (GO:0004857) -3.780.001PTEN, POT1, STK11, CDK4, MITF, CDKN2A
sequence-specific DNA binding (GO:0043565) -2.790.033PTEN, POT1, STK11, TERT, CDK4, MITF, CDKN2A
structure-specific DNA binding (GO:0043566) NEW4.980.021CDK4, TERT, POT1, XRCC3, PTEN
single-stranded telomeric DNA binding (GO:0043047) NEW7.440.002POT1, TERT
protein serine/threonine kinase activity (GO:0004674) -3.640.028POT1, BRAF, STK11, CDK4, PTEN, CDKN2A
single-stranded DNA binding (GO:0003697) -5.170.038POT1, CDK4, TERT
protein kinase regulator activity (GO:0019887) -4.60.001POT1, CDKN2A, STK11, CDK4, PTEN
telomeric DNA binding (GO:0042162) -6.340.008POT1, TERT
transcription factor binding (GO:0008134) -3.460.0XRCC3, PTEN, POT1, STK11, CDK4, MITF, CDKN2A
protein kinase binding (GO:0019901) -3.440.0MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
kinase binding (GO:0019900) -3.320.0MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
phosphatase binding (GO:0019902) NEW4.630.032CDKN2A, POT1, TERT, PTEN
protein domain specific binding (GO:0019904) -3.320.041PTEN, POT1, STK11, TERT, CDK4, MITF, CDKN2A
protein kinase activator activity (GO:0030295) NEW5.680.03STK11, POT1, PTEN
transcription regulatory region DNA binding (GO:0044212) NEW3.030.048TERT, POT1, CDK4, PTEN, MITF, CDKN2A
cyclin-dependent protein serine/threonine kinase inhibitor activity (GO:0004861) NEW7.250.033CDKN2A, CDK4
transferase activity, transferring phosphorus-containing groups (GO:0016772) -2.770.026TERT, POT1, BRAF, STK11, CDK4, PTEN, CDKN2A
protein binding (GO:0005515) -0.460.02TYR, XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
chromatin binding (GO:0003682) NEW3.640.017TERT, STK11, CDK4, PTEN, MITF, CDKN2A
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
organic substance metabolic process (GO:0071704) 0.6311TYR, XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
cellular process (GO:0009987) 0.2611TYR, XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
metabolic process (GO:0008152) 0.5811TYR, XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
cellular metabolic process (GO:0044237) 0.6911TYR, XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
primary metabolic process (GO:0044238) 0.6910XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
cellular macromolecule metabolic process (GO:0044260) 0.9310XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
regulation of cellular process (GO:0050794) 0.510XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
biological regulation (GO:0065007) 0.3910XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
positive regulation of biological process (GO:0048518) 1.210XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
macromolecule metabolic process (GO:0043170) 0.8310XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
regulation of biological process (GO:0050789) 0.4510XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
positive regulation of cellular process (GO:0048522) 1.310XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
developmental process (GO:0032502) 1.369TYR, MITF, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
positive regulation of metabolic process (GO:0009893) 1.749MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
regulation of metabolic process (GO:0019222) 1.029MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
regulation of macromolecule metabolic process (GO:0060255) 1.089MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
response to stimulus (GO:0050896) 1.229TYR, XRCC3, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
regulation of cellular metabolic process (GO:0031323) 1.079MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
positive regulation of macromolecule metabolic process (GO:0010604) 1.819MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
cellular component organization (GO:0016043) 1.249XRCC3, MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
single-organism developmental process (GO:0044767) 1.499TYR, MITF, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
single-organism cellular process (GO:0044763) 0.659TYR, MITF, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
cellular component organization or biogenesis (GO:0071840) 1.229XRCC3, MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
negative regulation of biological process (GO:0048519) 1.339MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
positive regulation of cellular metabolic process (GO:0031325) 1.819MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
single-organism process (GO:0044699) 0.489TYR, MITF, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
regulation of primary metabolic process (GO:0080090) 1.089MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
organic substance biosynthetic process (GO:1901576) 1.348TYR, XRCC3, PTEN, POT1, MC1R, TERT, MITF, CDKN2A
cellular component assembly (GO:0022607) 2.148XRCC3, PTEN, POT1, BRAF, STK11, TERT, MITF, CDKN2A
response to abiotic stimulus (GO:0009628) 2.88TYR, PTEN, MC1R, STK11, TERT, CDK4, XRCC3, BRAF
regulation of biosynthetic process (GO:0009889) 1.378MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A
cellular biosynthetic process (GO:0044249) 1.378TYR, XRCC3, PTEN, POT1, MC1R, TERT, MITF, CDKN2A
biosynthetic process (GO:0009058) 1.328TYR, XRCC3, PTEN, POT1, MC1R, TERT, MITF, CDKN2A
regulation of biological quality (GO:0065008) 1.688XRCC3, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
negative regulation of cellular process (GO:0048523) 1.418MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
cellular response to stimulus (GO:0051716) 1.977PTEN, MC1R, STK11, TERT, XRCC3, CDKN2A, BRAF
regulation of catalytic activity (GO:0050790) 1.977TERT, POT1, BRAF, STK11, CDK4, PTEN, CDKN2A
regulation of macromolecule biosynthetic process (GO:0010556) 1.437PTEN, POT1, MC1R, TERT, CDK4, MITF, CDKN2A
cellular aromatic compound metabolic process (GO:0006725) 1.37XRCC3, TERT, POT1, MC1R, TYR, MITF, CDKN2A
anatomical structure development (GO:0048856) 1.587TYR, PTEN, MC1R, STK11, CDK4, MITF, BRAF
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.467PTEN, POT1, MC1R, TERT, CDK4, MITF, CDKN2A
regulation of cellular component organization (GO:0051128) 2.017XRCC3, PTEN, POT1, BRAF, STK11, MITF, CDKN2A
response to stress (GO:0006950) 1.87XRCC3, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A
nitrogen compound metabolic process (GO:0006807) 1.137XRCC3, TERT, POT1, MC1R, TYR, MITF, CDKN2A
regulation of nitrogen compound metabolic process (GO:0051171) 1.367PTEN, POT1, MC1R, TERT, CDK4, MITF, CDKN2A
regulation of multicellular organismal process (GO:0051239) 1.877PTEN, MC1R, STK11, TERT, MITF, CDKN2A, BRAF
regulation of cellular biosynthetic process (GO:0031326) 1.387PTEN, POT1, MC1R, TERT, CDK4, MITF, CDKN2A
aromatic compound biosynthetic process (GO:0019438) 1.77XRCC3, TERT, POT1, MC1R, TYR, MITF, CDKN2A
regulation of molecular function (GO:0065009) 1.787TERT, POT1, BRAF, STK11, CDK4, PTEN, CDKN2A
organic cyclic compound biosynthetic process (GO:1901362) 1.667XRCC3, TERT, POT1, MC1R, TYR, MITF, CDKN2A
regulation of gene expression (GO:0010468) 1.377PTEN, MC1R, TERT, CDK4, MITF, CDKN2A, BRAF
organic cyclic compound metabolic process (GO:1901360) 1.267XRCC3, TERT, POT1, MC1R, TYR, MITF, CDKN2A
negative regulation of metabolic process (GO:0009892) 1.936TERT, POT1, STK11, PTEN, MITF, CDKN2A
positive regulation of biosynthetic process (GO:0009891) 2.296TERT, POT1, MC1R, CDK4, MITF, CDKN2A
macromolecular complex subunit organization (GO:0043933) 2.146XRCC3, MITF, BRAF, STK11, TERT, CDKN2A
positive regulation of response to stimulus (GO:0048584) 2.186PTEN, MC1R, STK11, TERT, CDKN2A, BRAF
regulation of response to stimulus (GO:0048583) 1.546PTEN, MC1R, STK11, TERT, CDKN2A, BRAF
positive regulation of signaling (GO:0023056) 2.416PTEN, MC1R, STK11, TERT, CDKN2A, BRAF
cellular nitrogen compound metabolic process (GO:0034641) 1.226XRCC3, TERT, POT1, MC1R, MITF, CDKN2A
positive regulation of gene expression (GO:0010628) 2.356TERT, MC1R, CDK4, MITF, CDKN2A, BRAF
signal transduction (GO:0007165) 1.286MC1R, STK11, CDK4, PTEN, CDKN2A, BRAF
regulation of signaling (GO:0023051) 1.726PTEN, MC1R, STK11, TERT, CDKN2A, BRAF
regulation of phosphate metabolic process (GO:0019220) 2.356MC1R, STK11, CDK4, PTEN, CDKN2A, BRAF
positive regulation of cell communication (GO:0010647) 2.416PTEN, MC1R, STK11, TERT, CDKN2A, BRAF
regulation of cell communication (GO:0010646) 1.736PTEN, MC1R, STK11, TERT, CDKN2A, BRAF
regulation of apoptotic process (GO:0042981) 2.56TERT, BRAF, CDK4, PTEN, MITF, CDKN2A
positive regulation of catalytic activity (GO:0043085) 2.46PTEN, POT1, BRAF, STK11, TERT, CDKN2A
cellular protein metabolic process (GO:0044267) 1.636PTEN, BRAF, STK11, CDK4, MITF, CDKN2A
regulation of cell death (GO:0010941) 2.436TERT, BRAF, CDK4, PTEN, MITF, CDKN2A
regulation of signal transduction (GO:0009966) 1.846PTEN, MC1R, STK11, TERT, CDKN2A, BRAF
positive regulation of signal transduction (GO:0009967) 2.56PTEN, MC1R, STK11, TERT, CDKN2A, BRAF
positive regulation of cellular biosynthetic process (GO:0031328) 2.36TERT, POT1, MC1R, CDK4, MITF, CDKN2A
macromolecular complex assembly (GO:0065003) 2.556XRCC3, MITF, BRAF, STK11, TERT, CDKN2A
regulation of developmental process (GO:0050793) 2.16TERT, BRAF, STK11, PTEN, MITF, CDKN2A
regulation of programmed cell death (GO:0043067) 2.496TERT, BRAF, CDK4, PTEN, MITF, CDKN2A
positive regulation of molecular function (GO:0044093) 2.236PTEN, POT1, BRAF, STK11, TERT, CDKN2A
regulation of cell proliferation (GO:0042127) 2.416PTEN, BRAF, STK11, CDK4, TERT, CDKN2A
nucleobase-containing compound metabolic process (GO:0006139) 1.356XRCC3, TERT, POT1, MC1R, MITF, CDKN2A
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.436TERT, POT1, MC1R, PTEN, MITF, CDKN2A
cellular protein modification process (GO:0006464) 1.796PTEN, BRAF, STK11, CDK4, MITF, CDKN2A
regulation of phosphorus metabolic process (GO:0051174) 2.356MC1R, STK11, CDK4, PTEN, CDKN2A, BRAF
macromolecule modification (GO:0043412) 1.736PTEN, BRAF, STK11, CDK4, MITF, CDKN2A
protein modification process (GO:0036211) 1.796PTEN, BRAF, STK11, CDK4, MITF, CDKN2A
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.296TERT, POT1, MC1R, CDK4, MITF, CDKN2A
response to chemical (GO:0042221) 1.986TYR, XRCC3, BRAF, CDK4, PTEN, TERT
heterocycle metabolic process (GO:0046483) 1.316XRCC3, TERT, POT1, MC1R, MITF, CDKN2A
nucleic acid metabolic process (GO:0090304) 1.466XRCC3, TERT, POT1, MC1R, MITF, CDKN2A
protein metabolic process (GO:0019538) 1.456PTEN, BRAF, STK11, CDK4, MITF, CDKN2A
regulation of transferase activity (GO:0051338) 2.886POT1, BRAF, STK11, CDK4, PTEN, CDKN2A
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.396TERT, POT1, MC1R, CDK4, MITF, CDKN2A
cellular response to stress (GO:0033554) 2.516XRCC3, PTEN, MC1R, STK11, TERT, CDKN2A
cellular developmental process (GO:0048869) 1.826TERT, BRAF, STK11, PTEN, MITF, CDKN2A
regulation of cellular localization (GO:0060341) 3.035TERT, CDKN2A, STK11, BRAF, PTEN
response to radiation (GO:0009314) 3.695TYR, MC1R, STK11, BRAF, XRCC3
negative regulation of cellular metabolic process (GO:0031324) 2.015POT1, CDKN2A, TERT, PTEN, MITF
cellular macromolecule biosynthetic process (GO:0034645) 1.665POT1, CDKN2A, XRCC3, TERT, MITF
intracellular signal transduction (GO:0035556) 2.395CDKN2A, MC1R, STK11, BRAF, PTEN
regulation of localization (GO:0032879) 1.945TERT, CDKN2A, STK11, BRAF, PTEN
negative regulation of macromolecule metabolic process (GO:0010605) 2.015POT1, CDKN2A, TERT, PTEN, MITF
regulation of kinase activity (GO:0043549) 3.075CDKN2A, STK11, CDK4, PTEN, BRAF
regulation of protein metabolic process (GO:0051246) 1.935CDKN2A, STK11, CDK4, PTEN, BRAF
positive regulation of protein metabolic process (GO:0051247) 2.435CDKN2A, STK11, CDK4, PTEN, BRAF
positive regulation of cellular protein metabolic process (GO:0032270) 2.495CDKN2A, STK11, CDK4, PTEN, BRAF
regulation of protein modification process (GO:0031399) 2.325CDKN2A, STK11, CDK4, PTEN, BRAF
heterocycle biosynthetic process (GO:0018130) 1.75POT1, CDKN2A, TERT, XRCC3, MITF
organelle organization (GO:0006996) 2.025CDKN2A, TERT, POT1, XRCC3, PTEN
multicellular organismal process (GO:0032501) 1.455TYR, BRAF, MC1R, PTEN, MITF
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.355POT1, MC1R, TERT, CDKN2A, MITF
regulation of protein kinase activity (GO:0045859) 3.155CDKN2A, STK11, CDK4, PTEN, BRAF
regulation of nucleic acid-templated transcription (GO:1903506) 1.555MC1R, PTEN, TERT, CDKN2A, MITF
regulation of cell differentiation (GO:0045595) 2.425CDKN2A, STK11, MITF, PTEN, BRAF
macromolecule biosynthetic process (GO:0009059) 1.615POT1, CDKN2A, TERT, XRCC3, MITF
regulation of RNA biosynthetic process (GO:2001141) 1.555MC1R, PTEN, TERT, CDKN2A, MITF
nucleobase-containing compound biosynthetic process (GO:0034654) 1.725POT1, CDKN2A, TERT, XRCC3, MITF
regulation of intracellular signal transduction (GO:1902531) 2.315CDKN2A, MC1R, STK11, BRAF, PTEN
response to organic substance (GO:0010033) 2.25TYR, CDK4, XRCC3, PTEN, BRAF
regulation of phosphorylation (GO:0042325) 2.55CDKN2A, STK11, CDK4, PTEN, BRAF
regulation of cellular protein metabolic process (GO:0032268) 1.995CDKN2A, STK11, CDK4, PTEN, BRAF
cellular nitrogen compound biosynthetic process (GO:0044271) 1.595CDKN2A, TERT, POT1, XRCC3, MITF
regulation of cell cycle (GO:0051726) 2.935CDKN2A, STK11, CDK4, PTEN, XRCC3
regulation of RNA metabolic process (GO:0051252) 1.525MC1R, PTEN, TERT, CDKN2A, MITF
regulation of transcription, DNA-templated (GO:0006355) 1.565CDKN2A, MC1R, TERT, PTEN, MITF
phosphate-containing compound metabolic process (GO:0006796) 2.165CDKN2A, STK11, CDK4, PTEN, BRAF
regulation of multicellular organismal development (GO:2000026) 2.315CDKN2A, STK11, PTEN, MITF, BRAF
phosphorus metabolic process (GO:0006793) 2.155CDKN2A, STK11, CDK4, PTEN, BRAF
regulation of protein phosphorylation (GO:0001932) 2.575CDKN2A, STK11, CDK4, PTEN, BRAF
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.564MC1R, TERT, CDKN2A, MITF
negative regulation of multicellular organismal process (GO:0051241) 2.844MC1R, STK11, CDKN2A, PTEN
negative regulation of biosynthetic process (GO:0009890) 2.474CDKN2A, STK11, POT1, MITF
regulation of organelle organization (GO:0033043) 2.724CDKN2A, POT1, BRAF, XRCC3
phosphorylation (GO:0016310) 2.634CDKN2A, STK11, BRAF, CDK4
homeostatic process (GO:0042592) 2.614POT1, STK11, TERT, XRCC3
negative regulation of signaling (GO:0023057) 2.654BRAF, STK11, TERT, PTEN
response to light stimulus (GO:0009416) 4.084TYR, MC1R, STK11, BRAF
regulation of mitotic cell cycle phase transition (GO:1901990) 4.234CDK4, CDKN2A, XRCC3, PTEN
regulation of protein serine/threonine kinase activity (GO:0071900) 3.584CDKN2A, STK11, BRAF, PTEN
response to organic cyclic compound (GO:0014070) 3.074TYR, BRAF, CDK4, PTEN
immune system process (GO:0002376) 2.294BRAF, STK11, PTEN, MITF
single-organism metabolic process (GO:0044710) 1.634BRAF, MC1R, TYR, PTEN
positive regulation of transferase activity (GO:0051347) 3.314BRAF, STK11, POT1, PTEN
protein complex subunit organization (GO:0071822) 2.64BRAF, STK11, TERT, MITF
positive regulation of phosphorus metabolic process (GO:0010562) 2.784MC1R, STK11, BRAF, PTEN
anatomical structure homeostasis (GO:0060249) 4.254POT1, STK11, TERT, XRCC3
regulation of cell cycle process (GO:0010564) 3.54CDK4, CDKN2A, XRCC3, PTEN
animal organ development (GO:0048513) 2.534TYR, BRAF, CDK4, PTEN
regulation of immune system process (GO:0002682) 2.54CDKN2A, STK11, PTEN, MITF
positive regulation of cellular component organization (GO:0051130) 2.684BRAF, STK11, POT1, MITF
negative regulation of developmental process (GO:0051093) 3.174CDKN2A, STK11, TERT, PTEN
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.554CDKN2A, POT1, TERT, MITF
positive regulation of phosphate metabolic process (GO:0045937) 2.784MC1R, STK11, BRAF, PTEN
neurological system process (GO:0050877) 2.644TYR, MC1R, BRAF, PTEN
protein complex assembly (GO:0006461) 2.784BRAF, STK11, TERT, MITF
regulation of mitotic cell cycle (GO:0007346) 3.714CDK4, CDKN2A, XRCC3, PTEN
negative regulation of cell cycle (GO:0045786) 3.674CDKN2A, STK11, CDK4, PTEN
regulation of cell cycle phase transition (GO:1901987) 4.154CDK4, CDKN2A, XRCC3, PTEN
positive regulation of transcription, DNA-templated (GO:0045893) 2.564MC1R, TERT, CDKN2A, MITF
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.474CDKN2A, POT1, TERT, MITF
positive regulation of intracellular signal transduction (GO:1902533) 2.954CDKN2A, MC1R, BRAF, PTEN
localization (GO:0051179) 1.44BRAF, STK11, POT1, TERT
system process (GO:0003008) 2.34TYR, MC1R, BRAF, PTEN
response to oxygen-containing compound (GO:1901700) 2.574TYR, BRAF, CDK4, PTEN
single-multicellular organism process (GO:0044707) 1.784MC1R, PTEN, BRAF, MITF
regulation of response to stress (GO:0080134) 2.534CDKN2A, TERT, PTEN, BRAF
positive regulation of protein modification process (GO:0031401) 2.74CDKN2A, STK11, BRAF, PTEN
positive regulation of RNA metabolic process (GO:0051254) 2.514MC1R, TERT, CDKN2A, MITF
positive regulation of RNA biosynthetic process (GO:1902680) 2.544MC1R, TERT, CDKN2A, MITF
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.244MC1R, TERT, CDKN2A, MITF
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.814MC1R, TERT, CDKN2A, MITF
regulation of cellular response to stress (GO:0080135) 3.44CDKN2A, TERT, BRAF, PTEN
DNA metabolic process (GO:0006259) 3.094MC1R, POT1, TERT, XRCC3
cell cycle process (GO:0022402) 2.754CDKN2A, STK11, CDK4, XRCC3
negative regulation of cell communication (GO:0010648) 2.664BRAF, STK11, TERT, PTEN
regulation of cell morphogenesis (GO:0022604) 3.43BRAF, STK11, PTEN
response to inorganic substance (GO:0010035) 3.563BRAF, CDK4, PTEN
regulation of cell aging (GO:0090342) 6.233CDKN2A, TERT, PTEN
negative regulation of growth (GO:0045926) 4.243CDKN2A, STK11, PTEN
RNA biosynthetic process (GO:0032774) 1.843CDKN2A, TERT, MITF
regulation of anatomical structure morphogenesis (GO:0022603) 2.793BRAF, STK11, PTEN
negative regulation of cellular biosynthetic process (GO:0031327) 2.493CDKN2A, POT1, MITF
regulation of transport (GO:0051049) 2.243CDKN2A, BRAF, PTEN
negative regulation of response to stimulus (GO:0048585) 2.523STK11, TERT, PTEN
regulation of protein localization to nucleus (GO:1900180) 4.343CDKN2A, STK11, TERT
regulation of neuron projection development (GO:0010975) 3.693BRAF, STK11, PTEN
regulation of cellular protein localization (GO:1903827) 3.433CDKN2A, STK11, TERT
negative regulation of gene expression (GO:0010629) 2.483CDKN2A, TERT, MITF
response to UV (GO:0009411) 4.883MC1R, STK11, TYR
cellular response to chemical stimulus (GO:0070887) 2.573BRAF, TERT, PTEN
positive regulation of cell death (GO:0010942) 3.323CDKN2A, CDK4, PTEN
response to purine-containing compound (GO:0014074) 4.673BRAF, TYR, PTEN
anatomical structure morphogenesis (GO:0009653) 2.533BRAF, STK11, PTEN
cell death (GO:0008219) 3.053CDKN2A, STK11, PTEN
cell cycle (GO:0007049) 3.143CDKN2A, STK11, CDK4
regulation of protein localization (GO:0032880) 2.883CDKN2A, STK11, TERT
response to endogenous stimulus (GO:0009719) 2.793BRAF, TYR, PTEN
regulation of neurogenesis (GO:0050767) 3.213BRAF, STK11, PTEN
single-organism biosynthetic process (GO:0044711) 2.83TYR, MC1R, PTEN
negative regulation of catalytic activity (GO:0043086) 3.03CDKN2A, POT1, PTEN
positive regulation of cell cycle (GO:0045787) 3.943CDKN2A, CDK4, XRCC3
negative regulation of signal transduction (GO:0009968) 2.753STK11, TERT, PTEN
positive regulation of developmental process (GO:0051094) 2.773CDKN2A, STK11, BRAF
response to lipid (GO:0033993) 3.113TYR, CDK4, PTEN
positive regulation of multicellular organismal process (GO:0051240) 2.493BRAF, STK11, TERT
negative regulation of transferase activity (GO:0051348) 3.873CDKN2A, POT1, PTEN
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63CDKN2A, POT1, MITF
regulation of cell development (GO:0060284) 3.013BRAF, STK11, PTEN
regulation of cell projection organization (GO:0031344) 3.383BRAF, STK11, PTEN
positive regulation of apoptotic process (GO:0043065) 3.383CDKN2A, CDK4, PTEN
regulation of neuron differentiation (GO:0045664) 3.393BRAF, STK11, PTEN
negative regulation of apoptotic process (GO:0043066) 3.043BRAF, TERT, PTEN
nucleic acid-templated transcription (GO:0097659) 1.913CDKN2A, TERT, MITF
response to nitrogen compound (GO:1901698) 3.123BRAF, TYR, PTEN
negative regulation of molecular function (GO:0044092) 2.743CDKN2A, POT1, PTEN
response to oxygen levels (GO:0070482) 4.023CDK4, TERT, PTEN
negative regulation of programmed cell death (GO:0043069) 3.023BRAF, TERT, PTEN
response to organophosphorus (GO:0046683) 4.793BRAF, TYR, PTEN
telomere maintenance (GO:0000723) 5.373POT1, TERT, XRCC3
positive regulation of cell proliferation (GO:0008284) 3.013CDK4, TERT, PTEN
negative regulation of cell proliferation (GO:0008285) 3.263CDKN2A, STK11, PTEN
protein phosphorylation (GO:0006468) 2.893BRAF, STK11, CDK4
cell differentiation (GO:0030154) 2.143BRAF, STK11, MITF
regulation of growth (GO:0040008) 3.263CDKN2A, STK11, PTEN
positive regulation of cell cycle process (GO:0090068) 4.253CDKN2A, CDK4, XRCC3
regulation of cell-substrate adhesion (GO:0010810) 4.563CDKN2A, BRAF, PTEN
negative regulation of cell death (GO:0060548) 2.953BRAF, TERT, PTEN
apoptotic process (GO:0006915) 3.143CDKN2A, STK11, PTEN
cellular response to DNA damage stimulus (GO:0006974) 3.173MC1R, STK11, XRCC3
programmed cell death (GO:0012501) 3.13CDKN2A, STK11, PTEN
positive regulation of cellular protein localization (GO:1903829) 3.853CDKN2A, STK11, TERT
positive regulation of protein phosphorylation (GO:0001934) 2.953BRAF, STK11, PTEN
response to metal ion (GO:0010038) 3.913BRAF, CDK4, PTEN
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.913BRAF, STK11, PTEN
regulation of cell adhesion (GO:0030155) 3.273CDKN2A, BRAF, PTEN
establishment of localization (GO:0051234) 1.483BRAF, POT1, TERT
regulation of protein kinase B signaling (GO:0051896) 4.923MC1R, STK11, PTEN
negative regulation of RNA metabolic process (GO:0051253) 2.663CDKN2A, TERT, MITF
regulation of axonogenesis (GO:0050770) 4.593BRAF, STK11, PTEN
RNA metabolic process (GO:0016070) 1.593CDKN2A, TERT, MITF
pigmentation (GO:0043473) 5.93MC1R, TYR, MITF
positive regulation of phosphorylation (GO:0042327) 2.93BRAF, STK11, PTEN
positive regulation of protein localization to nucleus (GO:1900182) 4.873CDKN2A, STK11, TERT
aging (GO:0007568) 4.163CDKN2A, TERT, PTEN
chromosome organization (GO:0051276) 3.793POT1, TERT, XRCC3
reproductive process (GO:0022414) 2.553STK11, XRCC3, PTEN
response to organonitrogen compound (GO:0010243) 3.23BRAF, TYR, PTEN
regulation of protein stability (GO:0031647) 4.333CDKN2A, TERT, PTEN
response to drug (GO:0042493) 3.713BRAF, CDK4, PTEN
telomere organization (GO:0032200) 5.333POT1, TERT, XRCC3
positive regulation of programmed cell death (GO:0043068) 3.383CDKN2A, CDK4, PTEN
regulation of cellular component biogenesis (GO:0044087) 3.083BRAF, PTEN, MITF
regulation of nervous system development (GO:0051960) 3.13BRAF, STK11, PTEN
establishment of protein localization (GO:0045184) 2.533BRAF, POT1, TERT
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533CDKN2A, POT1, MITF
DNA biosynthetic process (GO:0071897) 4.893POT1, TERT, XRCC3
organic hydroxy compound metabolic process (GO:1901615) 3.843MC1R, TYR, PTEN
regulation of extrinsic apoptotic signaling pathway (GO:2001236) 4.692TERT, PTEN
developmental growth (GO:0048589) 4.052STK11, PTEN
regulation of apoptotic signaling pathway (GO:2001233) 3.832TERT, PTEN
regulation of axon regeneration (GO:0048679) 6.782BRAF, PTEN
activation of protein kinase activity (GO:0032147) 4.082BRAF, STK11
behavior (GO:0007610) 3.472BRAF, PTEN
learning or memory (GO:0007611) 4.332BRAF, PTEN
regulation of Wnt signaling pathway (GO:0030111) 3.982STK11, TERT
small molecule metabolic process (GO:0044281) 2.382TYR, PTEN
cell surface receptor signaling pathway (GO:0007166) 2.092STK11, PTEN
cellular component morphogenesis (GO:0032989) 3.52STK11, PTEN
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114) 3.792STK11, PTEN
mitochondrion organization (GO:0007005) 3.692CDKN2A, TERT
telomere maintenance via telomerase (GO:0007004) 6.92POT1, TERT
pigment metabolic process (GO:0042440) 5.592MC1R, TYR
secondary metabolite biosynthetic process (GO:0044550) 6.732MC1R, TYR
regulation of cytoskeleton organization (GO:0051493) 3.722BRAF, XRCC3
cellular response to oxygen levels (GO:0071453) 4.972TERT, PTEN
peptidyl-amino acid modification (GO:0018193) 2.982CDKN2A, MITF
rhythmic process (GO:0048511) 4.022CDK4, PTEN
positive regulation of neuron differentiation (GO:0045666) 3.982BRAF, STK11
positive regulation of cell development (GO:0010720) 3.572BRAF, STK11
regulation of signal transduction by p53 class mediator (GO:1901796) 4.632CDKN2A, STK11
regulation of myeloid cell apoptotic process (GO:0033032) 6.552CDKN2A, PTEN
regulation of DNA metabolic process (GO:0051052) 3.872CDKN2A, POT1
negative regulation of transport (GO:0051051) 3.62BRAF, PTEN
DNA repair (GO:0006281) 3.592MC1R, XRCC3
G1/S transition of mitotic cell cycle (GO:0000082) 5.122CDKN2A, CDK4
sensory perception (GO:0007600) 2.932MC1R, TYR
negative regulation of epithelial cell proliferation (GO:0050680) 4.982STK11, PTEN
developmental process involved in reproduction (GO:0003006) 3.362STK11, PTEN
regulation of cell size (GO:0008361) 5.422CDK4, PTEN
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062STK11, PTEN
regulation of proteolysis (GO:0030162) 3.22CDKN2A, PTEN
mitotic G1 phase (GO:0000080) 6.332CDKN2A, CDK4
regulation of hemopoiesis (GO:1903706) 4.02CDKN2A, MITF
RNA-dependent DNA biosynthetic process (GO:0006278) 6.262POT1, TERT
response to external stimulus (GO:0009605) 2.552TYR, PTEN
cell motility (GO:0048870) 3.022PTEN, MITF
peptidyl-lysine modification (GO:0018205) 3.982CDKN2A, MITF
single-organism behavior (GO:0044708) 3.792BRAF, PTEN
Wnt signaling pathway (GO:0016055) 3.882STK11, PTEN
positive regulation of organelle organization (GO:0010638) 3.382BRAF, POT1
negative regulation of cell adhesion (GO:0007162) 4.332CDKN2A, PTEN
regulation of cyclin-dependent protein kinase activity (GO:1904029) 5.212CDKN2A, PTEN
regulation of cellular component size (GO:0032535) 4.212CDK4, PTEN
negative regulation of kinase activity (GO:0033673) 4.222CDKN2A, PTEN
regulation of membrane potential (GO:0042391) 3.892CDKN2A, PTEN
regulation of catabolic process (GO:0009894) 3.522CDKN2A, PTEN
negative regulation of cell aging (GO:0090344) 6.92TERT, PTEN
positive regulation of kinase activity (GO:0033674) 3.542BRAF, STK11
movement of cell or subcellular component (GO:0006928) 2.612PTEN, MITF
protein stabilization (GO:0050821) 4.862CDKN2A, PTEN
regulation of synaptic plasticity (GO:0048167) 4.782BRAF, PTEN
regulation of cell migration (GO:0030334) 3.232BRAF, PTEN
negative regulation of protein serine/threonine kinase activity (GO:0071901) 4.922CDKN2A, PTEN
replicative senescence (GO:0090399) 7.242CDKN2A, TERT
T cell selection (GO:0045058) 6.472BRAF, STK11
immune response-regulating signaling pathway (GO:0002764) 3.722STK11, PTEN
positive regulation of hydrolase activity (GO:0051345) 2.912CDKN2A, POT1
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962STK11, PTEN
regulation of anatomical structure size (GO:0090066) 3.782CDK4, PTEN
negative regulation of cyclin-dependent protein kinase activity (GO:1904030) 6.432CDKN2A, PTEN
positive regulation of immune system process (GO:0002684) 2.962STK11, PTEN
cellular response to hypoxia (GO:0071456) 5.112TERT, PTEN
positive regulation of cell projection organization (GO:0031346) 3.992BRAF, STK11
negative regulation of cell-substrate adhesion (GO:0010812) 5.762CDKN2A, PTEN
single organism reproductive process (GO:0044702) 2.732STK11, PTEN
organ morphogenesis (GO:0009887) 3.552BRAF, PTEN
establishment of protein localization to telomere (GO:0070200) 7.942POT1, TERT
circadian rhythm (GO:0007623) 4.792CDK4, PTEN
melanin metabolic process (GO:0006582) 7.092MC1R, TYR
cell migration (GO:0016477) 3.122PTEN, MITF
cell cycle arrest (GO:0007050) 4.692CDKN2A, STK11
canonical Wnt signaling pathway (GO:0060070) 5.262STK11, PTEN
cellular response to radiation (GO:0071478) 4.812MC1R, STK11
melanin biosynthetic process (GO:0042438) 7.162MC1R, TYR
positive regulation of cell morphogenesis involved in differentiation (GO:0010770) 4.652BRAF, STK11
negative regulation of intracellular signal transduction (GO:1902532) 3.632STK11, PTEN
pigment biosynthetic process (GO:0046148) 5.862MC1R, TYR
negative regulation of cell cycle process (GO:0010948) 4.372CDK4, PTEN
regulation of hydrolase activity (GO:0051336) 2.532CDKN2A, POT1
positive regulation of MAPK cascade (GO:0043410) 3.572BRAF, PTEN
immune response-activating signal transduction (GO:0002757) 3.82STK11, PTEN
response to decreased oxygen levels (GO:0036293) 4.092TERT, PTEN
negative regulation of protein modification process (GO:0031400) 3.42CDKN2A, PTEN
cognition (GO:0050890) 4.22BRAF, PTEN
establishment of protein localization to chromosome (GO:0070199) 7.162POT1, TERT
positive regulation of nervous system development (GO:0051962) 3.642BRAF, STK11
neuron projection morphogenesis (GO:0048812) 4.342STK11, PTEN
regulation of cell motility (GO:2000145) 3.162BRAF, PTEN
regulation of dendrite morphogenesis (GO:0048814) 5.412STK11, PTEN
negative regulation of cell motility (GO:2000146) 4.362BRAF, PTEN
organic hydroxy compound biosynthetic process (GO:1901617) 4.982MC1R, TYR
regulation of chromosome organization (GO:0033044) 4.112POT1, XRCC3
cellular response to light stimulus (GO:0071482) 5.222MC1R, STK11
negative regulation of cell growth (GO:0030308) 4.582CDKN2A, STK11
regulation of response to external stimulus (GO:0032101) 3.062BRAF, PTEN
regulation of synapse structure or activity (GO:0050803) 4.772BRAF, PTEN
protein modification by small protein conjugation or removal (GO:0070647) 2.952CDKN2A, MITF
positive regulation of synaptic transmission (GO:0050806) 5.072BRAF, PTEN
negative regulation of synaptic transmission (GO:0050805) 5.672BRAF, PTEN
modulation of synaptic transmission (GO:0050804) 4.092BRAF, PTEN
regulation of protein catabolic process (GO:0042176) 3.832CDKN2A, PTEN
cellular response to abiotic stimulus (GO:0071214) 4.152MC1R, STK11
cellular response to UV (GO:0034644) 5.522MC1R, STK11
mitotic cell cycle phase transition (GO:0044772) 4.272CDKN2A, CDK4
response to hypoxia (GO:0001666) 4.132TERT, PTEN
regulation of MAPK cascade (GO:0043408) 3.222BRAF, PTEN
negative regulation of protein metabolic process (GO:0051248) 2.822CDKN2A, PTEN
negative regulation of phosphorylation (GO:0042326) 3.72CDKN2A, PTEN
response to ionizing radiation (GO:0010212) 4.742STK11, XRCC3
protein modification by small protein conjugation (GO:0032446) 3.12CDKN2A, MITF
negative regulation of phosphorus metabolic process (GO:0010563) 3.452CDKN2A, PTEN
positive regulation of protein modification by small protein conjugation or removal (GO:1903322) 4.482CDKN2A, PTEN
positive regulation of neurogenesis (GO:0050769) 3.772BRAF, STK11
regulation of protein modification by small protein conjugation or removal (GO:1903320) 4.142CDKN2A, PTEN
positive T cell selection (GO:0043368) 7.332BRAF, STK11
regulation of neuron projection regeneration (GO:0070570) 6.682BRAF, PTEN
regulation of cell-matrix adhesion (GO:0001952) 5.212CDKN2A, PTEN
regulation of protein ubiquitination (GO:0031396) 4.222CDKN2A, PTEN
regulation of response to wounding (GO:1903034) 4.742BRAF, PTEN
multicellular organismal reproductive process (GO:0048609) 3.352STK11, PTEN
cell proliferation (GO:0008283) 3.232TYR, PTEN
establishment of protein localization to organelle (GO:0072594) 3.922POT1, TERT
regulation of proteolysis involved in cellular protein catabolic process (GO:1903050) 4.322CDKN2A, PTEN
regulation of immune response (GO:0050776) 2.982STK11, PTEN
negative regulation of locomotion (GO:0040013) 4.222BRAF, PTEN
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712CDKN2A, MITF
G1 phase (GO:0051318) 6.332CDKN2A, CDK4
negative regulation of cell differentiation (GO:0045596) 3.332CDKN2A, PTEN
regulation of cell growth (GO:0001558) 3.752CDKN2A, STK11
negative regulation of transcription, DNA-templated (GO:0045892) 2.752CDKN2A, MITF
telomere maintenance via telomere lengthening (GO:0010833) 6.642POT1, TERT
axonogenesis (GO:0007409) 4.742STK11, PTEN
phenol-containing compound metabolic process (GO:0018958) 5.332MC1R, TYR
protein sumoylation (GO:0016925) 4.982CDKN2A, MITF
cell part morphogenesis (GO:0032990) 3.992STK11, PTEN
response to nutrient (GO:0007584) 4.492TYR, PTEN
negative regulation of cellular protein metabolic process (GO:0032269) 2.882CDKN2A, PTEN
regulation of sequence-specific DNA binding transcription factor activity (GO:0051090) 3.832CDKN2A, PTEN
regulation of epithelial cell proliferation (GO:0050678) 4.062STK11, PTEN
cell aging (GO:0007569) 5.542CDKN2A, TERT
regulation of dendrite development (GO:0050773) 4.932STK11, PTEN
positive regulation of axonogenesis (GO:0050772) 5.492BRAF, STK11
long-term synaptic potentiation (GO:0060291) 6.072BRAF, PTEN
negative regulation of cell-matrix adhesion (GO:0001953) 6.292CDKN2A, PTEN
positive regulation of immune response (GO:0050778) 3.42STK11, PTEN
positive regulation of proteolysis (GO:0045862) 3.862CDKN2A, PTEN
system development (GO:0048731) 2.922STK11, PTEN
gland development (GO:0048732) 4.152BRAF, TYR
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.562BRAF, PTEN
regulation of cellular senescence (GO:2000772) 6.472CDKN2A, TERT
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.232BRAF, PTEN
regulation of ubiquitin-protein transferase activity (GO:0051438) 4.982CDKN2A, PTEN
response to extracellular stimulus (GO:0009991) 3.712TYR, PTEN
regulation of cellular catabolic process (GO:0031329) 3.832CDKN2A, PTEN
cell projection organization (GO:0030030) 3.142STK11, PTEN
mitotic cell cycle process (GO:1903047) 3.122CDKN2A, CDK4
cell cycle phase transition (GO:0044770) 4.242CDKN2A, CDK4
negative regulation of cell migration (GO:0030336) 4.412BRAF, PTEN
cell cycle phase (GO:0022403) 4.392CDKN2A, CDK4
negative regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045736) 6.592CDKN2A, PTEN
multicellular organism development (GO:0007275) 2.542MC1R, MITF
cell division (GO:0051301) 3.682CDKN2A, CDK4
response to nutrient levels (GO:0031667) 3.772TYR, PTEN
growth (GO:0040007) 3.82STK11, PTEN
positive regulation of protein kinase activity (GO:0045860) 3.612BRAF, STK11
regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2000058) 5.122CDKN2A, PTEN
regulation of locomotion (GO:0040012) 3.122BRAF, PTEN
thymus development (GO:0048538) 5.882BRAF, TYR
hematopoietic or lymphoid organ development (GO:0048534) 4.492BRAF, TYR
regulation of cell cycle arrest (GO:0071156) 5.052CDKN2A, CDK4
transcription, DNA-templated (GO:0006351) 1.912CDKN2A, MITF
positive regulation of mitotic cell cycle (GO:0045931) 4.982CDK4, XRCC3
antigen receptor-mediated signaling pathway (GO:0050851) 4.432STK11, PTEN
T cell receptor signaling pathway (GO:0050852) 4.712STK11, PTEN
negative regulation of protein kinase activity (GO:0006469) 4.292CDKN2A, PTEN
regulation of cellular protein catabolic process (GO:1903362) 4.232CDKN2A, PTEN
negative regulation of phosphate metabolic process (GO:0045936) 3.452CDKN2A, PTEN
phenol-containing compound biosynthetic process (GO:0046189) 6.262MC1R, TYR
autophagy (GO:0006914) 3.822CDKN2A, STK11
secondary metabolic process (GO:0019748) 5.882MC1R, TYR
negative regulation of RNA biosynthetic process (GO:1902679) 2.72CDKN2A, MITF
cellular response to decreased oxygen levels (GO:0036294) 5.052TERT, PTEN
biological phase (GO:0044848) 4.372CDKN2A, CDK4
cell cycle G1/S phase transition (GO:0044843) 5.122CDKN2A, CDK4
regulation of vesicle-mediated transport (GO:0060627) 3.632BRAF, PTEN
regulation of G2/M transition of mitotic cell cycle (GO:0010389) 5.762CDKN2A, CDK4
locomotion (GO:0040011) 2.912PTEN, MITF
positive regulation of cell differentiation (GO:0045597) 3.012BRAF, STK11
negative regulation of cellular component movement (GO:0051271) 4.222BRAF, PTEN
regulation of cellular component movement (GO:0051270) 3.082BRAF, PTEN
cell projection morphogenesis (GO:0048858) 4.052STK11, PTEN
regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0000079) 5.262CDKN2A, PTEN
regulation of leukocyte apoptotic process (GO:2000106) 5.332CDKN2A, PTEN
regulation of leukocyte differentiation (GO:1902105) 4.262CDKN2A, MITF
response to cAMP (GO:0051591) 5.082BRAF, TYR
regulation of cell cycle G2/M phase transition (GO:1902749) 5.632CDKN2A, CDK4
activation of immune response (GO:0002253) 3.672STK11, PTEN
negative regulation of protein phosphorylation (GO:0001933) 3.792CDKN2A, PTEN
positive regulation of cellular component biogenesis (GO:0044089) 3.712BRAF, MITF
RNA processing (GO:0006396) 3.012CDKN2A, TERT
positive regulation of neuron projection development (GO:0010976) 4.262BRAF, STK11

NET-GE enrichment

Term New enriched termICP valueGenes
negative regulation of kinase activity (GO:0033673) -4.220.003TERT, CDKN2A, STK11, CDK4, PTEN
regulation of cell proliferation (GO:0042127) -2.410.007PTEN, BRAF, STK11, CDK4, MITF, CDKN2A
regulation of extrinsic apoptotic signaling pathway (GO:2001236) -4.690.022TERT, CDKN2A, STK11, CDK4, PTEN
negative regulation of transferase activity (GO:0051348) -3.870.0PTEN, POT1, STK11, CDK4, TERT, CDKN2A
positive regulation of metabolic process (GO:0009893) -1.740.029MITF, POT1, MC1R, STK11, CDK4, PTEN, CDKN2A, BRAF
negative regulation of cell growth (GO:0030308) -4.580.032POT1, CDKN2A, STK11, CDK4, PTEN
positive regulation of kinase activity (GO:0033674) -3.540.041MITF, POT1, BRAF, STK11, CDK4, PTEN, CDKN2A
response to radiation (GO:0009314) -3.690.024TERT, POT1, MC1R, STK11, CDK4, PTEN, BRAF
positive regulation of cellular metabolic process (GO:0031325) -1.810.019MITF, POT1, MC1R, STK11, CDK4, PTEN, CDKN2A, BRAF
activation of protein kinase activity (GO:0032147) -4.080.0MITF, POT1, BRAF, STK11, CDK4, PTEN, CDKN2A
regulation of cellular component organization (GO:0051128) -2.010.027PTEN, POT1, BRAF, STK11, XRCC3, CDKN2A
regulation of response to stress (GO:0080134) -2.530.014MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
regulation of MAP kinase activity (GO:0043405) NEW3.950.001PTEN, POT1, STK11, TERT, CDK4, MITF, CDKN2A
response to UV (GO:0009411) -4.880.025MC1R, STK11, POT1, PTEN
telomere formation via telomerase (GO:0032203) NEW9.730.001POT1, TERT
positive regulation of intracellular signal transduction (GO:1902533) -2.950.002MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
cell cycle arrest (GO:0007050) -4.690.0POT1, CDKN2A, STK11, CDK4, PTEN
positive regulation of protein serine/threonine kinase activity (GO:0071902) NEW4.060.013PTEN, POT1, STK11, CDK4, MITF, CDKN2A
regulation of protein serine/threonine kinase activity (GO:0071900) -3.580.015PTEN, POT1, STK11, TERT, CDK4, MITF, CDKN2A
regulation of protein kinase B signaling (GO:0051896) -4.920.049MC1R, STK11, PTEN
negative regulation of MAPK cascade (GO:0043409) NEW4.740.005CDK4, POT1, TERT, PTEN, BRAF
telomere maintenance via telomerase (GO:0007004) -6.90.022POT1, TERT
positive regulation of cell cycle process (GO:0090068) -4.250.01CDK4, CDKN2A, XRCC3, PTEN
regulation of mitotic cell cycle (GO:0007346) -3.710.005XRCC3, POT1, TERT, CDK4, PTEN, MITF, CDKN2A
cellular macromolecule catabolic process (GO:0044265) NEW3.190.04XRCC3, POT1, BRAF, TERT, CDK4, MITF, CDKN2A
negative regulation of cell cycle (GO:0045786) -3.670.02POT1, CDKN2A, STK11, CDK4, PTEN
positive regulation of macromolecule metabolic process (GO:0010604) -1.810.013MITF, POT1, MC1R, STK11, CDK4, PTEN, CDKN2A, BRAF
secondary metabolite biosynthetic process (GO:0044550) -6.730.001MC1R, TYR, MITF
positive regulation of signal transduction (GO:0009967) -2.50.049MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
negative regulation of phosphorus metabolic process (GO:0010563) -3.450.0MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
regulation of cell cycle process (GO:0010564) -3.50.026XRCC3, PTEN, STK11, TERT, CDK4, MITF, CDKN2A
negative regulation of protein kinase activity (GO:0006469) -4.290.002TERT, CDKN2A, STK11, CDK4, PTEN
regulation of leukocyte apoptotic process (GO:2000106) -5.330.022CDK4, CDKN2A, PTEN, MITF
cellular response to abiotic stimulus (GO:0071214) -4.150.01POT1, MC1R, STK11, CDK4, PTEN, BRAF
positive T cell selection (GO:0043368) -7.330.031BRAF, STK11
regulation of kinase activity (GO:0043549) -3.070.003MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
negative regulation of phosphate metabolic process (GO:0045936) -3.450.0MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
positive regulation of cellular process (GO:0048522) -1.30.007XRCC3, MITF, POT1, MC1R, STK11, CDK4, PTEN, CDKN2A, BRAF
positive regulation of biological process (GO:0048518) -1.20.028XRCC3, MITF, POT1, MC1R, STK11, CDK4, PTEN, CDKN2A, BRAF
negative regulation of biological process (GO:0048519) -1.330.005MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
signal transduction by phosphorylation (GO:0023014) NEW3.790.039POT1, BRAF, STK11, CDK4, PTEN
regulation of MAPK cascade (GO:0043408) -3.220.003MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
developmental process (GO:0032502) -1.360.031TYR, MITF, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
regulation of protein kinase activity (GO:0045859) -3.150.002MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
cellular component assembly (GO:0022607) -2.140.018PTEN, POT1, BRAF, STK11, TERT, MITF, CDKN2A
positive regulation of transferase activity (GO:0051347) -3.310.007MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
response to abiotic stimulus (GO:0009628) -2.80.029MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
melanin metabolic process (GO:0006582) -7.090.026MC1R, TYR, MITF
response to acid chemical (GO:0001101) NEW4.050.044PTEN, POT1, BRAF, CDK4, MITF, CDKN2A
negative regulation of protein metabolic process (GO:0051248) -2.820.001MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
sensory perception (GO:0007600) -2.930.043TYR, PTEN, POT1, MC1R, CDK4, MITF, BRAF
cellular response to DNA damage stimulus (GO:0006974) -3.170.033XRCC3, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A
canonical Wnt signaling pathway (GO:0060070) -5.260.021STK11, PTEN, MITF
organic hydroxy compound biosynthetic process (GO:1901617) -4.980.0TYR, PTEN, MC1R, STK11, MITF, BRAF
regulation of proteolysis (GO:0030162) -3.20.046PTEN, POT1, BRAF, TERT, CDK4, MITF, CDKN2A
melanin biosynthetic process (GO:0042438) -7.160.022MC1R, TYR, MITF
phenol-containing compound metabolic process (GO:0018958) -5.330.001MC1R, POT1, TYR, MITF, BRAF
negative regulation of phosphorylation (GO:0042326) -3.70.0MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
single-organism developmental process (GO:0044767) -1.490.013TYR, MITF, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
negative regulation of cellular protein metabolic process (GO:0032269) -2.880.0MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
positive regulation of protein kinase activity (GO:0045860) -3.610.031MITF, POT1, BRAF, STK11, CDK4, PTEN, CDKN2A
aging (GO:0007568) -4.160.007PTEN, POT1, STK11, TERT, CDK4, MITF, CDKN2A
cell aging (GO:0007569) -5.540.004CDKN2A, TERT, PTEN
regulation of cell cycle (GO:0051726) -2.930.007XRCC3, PTEN, POT1, STK11, TERT, CDK4, MITF, CDKN2A
replicative senescence (GO:0090399) -7.240.001CDKN2A, TERT, PTEN
regulation of cellular response to stress (GO:0080135) -3.40.01TERT, POT1, CDK4, PTEN, MITF, CDKN2A
regulation of transferase activity (GO:0051338) -2.880.007MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
telomere assembly (GO:0032202) NEW8.340.017POT1, TERT
regulation of cysteine-type endopeptidase activity (GO:2000116) NEW4.370.042POT1, CDKN2A, TERT, CDK4, PTEN
regulation of cysteine-type endopeptidase activity involved in apoptotic process (GO:0043281) NEW4.430.031POT1, CDKN2A, TERT, CDK4, PTEN
lymphocyte differentiation (GO:0030098) NEW4.490.044CDK4, POT1, PTEN, MITF, BRAF
regulation of peptidase activity (GO:0052547) NEW3.750.006PTEN, POT1, BRAF, TERT, CDK4, MITF, CDKN2A
negative regulation of protein phosphorylation (GO:0001933) -3.790.0MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
regulation of protein phosphorylation (GO:0001932) -2.570.025MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
negative regulation of protein modification process (GO:0031400) -3.40.0MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
negative regulation of cellular process (GO:0048523) -1.410.032MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
organic hydroxy compound metabolic process (GO:1901615) -3.840.001TYR, MITF, POT1, MC1R, STK11, CDK4, PTEN, BRAF
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1111TYR, XRCC3, MITF, POT1, MC1R, STK11, TERT, CDK4, PTEN, CDKN2A, BRAF
intracellular membrane-bounded organelle (GO:0043231) 0.610TYR, XRCC3, MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
nucleus (GO:0005634) 1.0710TYR, XRCC3, MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
intracellular organelle (GO:0043229) 0.5110TYR, XRCC3, MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
intracellular part (GO:0044424) 0.2810TYR, XRCC3, MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
membrane-bounded organelle (GO:0043227) 0.4710TYR, XRCC3, MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
organelle (GO:0043226) 0.410TYR, XRCC3, MITF, POT1, BRAF, STK11, TERT, CDK4, PTEN, CDKN2A
intracellular organelle part (GO:0044446) 0.819TYR, XRCC3, PTEN, POT1, STK11, TERT, CDK4, MITF, CDKN2A
organelle part (GO:0044422) 0.799TYR, XRCC3, PTEN, POT1, STK11, TERT, CDK4, MITF, CDKN2A
nucleoplasm (GO:0005654) 1.898XRCC3, PTEN, POT1, STK11, TERT, CDK4, MITF, CDKN2A
cytoplasm (GO:0005737) 1.018TYR, PTEN, BRAF, STK11, TERT, CDK4, XRCC3, CDKN2A
cytoplasmic part (GO:0044444) 0.828TYR, PTEN, BRAF, STK11, TERT, CDK4, XRCC3, CDKN2A
nuclear part (GO:0044428) 1.558XRCC3, PTEN, POT1, STK11, TERT, CDK4, MITF, CDKN2A
macromolecular complex (GO:0032991) 1.357XRCC3, POT1, STK11, TERT, CDK4, MITF, CDKN2A
protein complex (GO:0043234) 1.516XRCC3, MITF, STK11, CDK4, TERT, CDKN2A
cytosol (GO:0005829) 1.686TYR, BRAF, STK11, CDK4, PTEN, CDKN2A
membrane (GO:0016020) 0.686TYR, MC1R, STK11, CDK4, PTEN, BRAF
mitochondrion (GO:0005739) 2.426XRCC3, PTEN, BRAF, STK11, TERT, CDKN2A
chromosomal part (GO:0044427) 3.185POT1, CDKN2A, TERT, CDK4, XRCC3
non-membrane-bounded organelle (GO:0043228) 1.764CDKN2A, POT1, TERT, CDK4
intracellular non-membrane-bounded organelle (GO:0043232) 1.764CDKN2A, POT1, TERT, CDK4
nuclear body (GO:0016604) 3.943CDKN2A, TERT, PTEN
nucleolus (GO:0005730) 3.063CDKN2A, TERT, CDK4
chromosome, telomeric region (GO:0000781) 4.93POT1, TERT, XRCC3
nuclear chromosome part (GO:0044454) 3.673POT1, TERT, XRCC3
nucleoplasm part (GO:0044451) 3.223CDKN2A, TERT, PTEN
nuclear chromosome, telomeric region (GO:0000784) 5.163POT1, TERT, XRCC3
plasma membrane (GO:0005886) 1.393BRAF, MC1R, PTEN
membrane part (GO:0044425) 0.953MC1R, TYR, PTEN
perinuclear region of cytoplasm (GO:0048471) 3.353TYR, CDK4, XRCC3
chromosomal region (GO:0098687) 4.193POT1, TERT, XRCC3
PML body (GO:0016605) 5.242TERT, PTEN
neuron projection (GO:0043005) 3.122BRAF, PTEN
vesicle (GO:0031982) 1.642TYR, STK11
protein-DNA complex (GO:0032993) 5.032POT1, TERT
transferase complex, transferring phosphorus-containing groups (GO:0061695) 4.612CDK4, TERT
chromosome (GO:0005694) 3.782POT1, TERT
integral component of membrane (GO:0016021) 1.142MC1R, TYR
membrane-bounded vesicle (GO:0031988) 1.712TYR, STK11
neuron part (GO:0097458) 2.642BRAF, PTEN
nuclear telomere cap complex (GO:0000783) 7.322POT1, TERT
telomere cap complex (GO:0000782) 7.322POT1, TERT
chromatin (GO:0000785) 3.992CDKN2A, CDK4
organelle membrane (GO:0031090) 1.972TYR, CDK4
transferase complex (GO:1990234) 3.322CDK4, TERT
cell projection (GO:0042995) 2.472BRAF, PTEN
plasma membrane part (GO:0044459) 1.952MC1R, PTEN
intrinsic component of membrane (GO:0031224) 1.132MC1R, TYR
catalytic complex (GO:1902494) 2.92CDK4, TERT

NET-GE enrichment

Term New enriched termICP valueGenes
nucleoplasm (GO:0005654) -1.890.012XRCC3, PTEN, POT1, STK11, TERT, CDK4, MITF, CDKN2A
protein kinase complex (GO:1902911) NEW5.310.032BRAF, STK11, CDK4
chromosome, telomeric region (GO:0000781) -4.90.03POT1, TERT
nuclear chromosome part (GO:0044454) -3.670.023CDK4, CDKN2A, POT1, TERT, PTEN
nuclear telomere cap complex (GO:0000783) -7.320.003POT1, TERT
telomere cap complex (GO:0000782) -7.320.003POT1, TERT
chromosomal part (GO:0044427) -3.180.047XRCC3, POT1, CDK4, PTEN, TERT, CDKN2A
melanosome membrane (GO:0033162) NEW7.610.015TYR, MITF
chromosomal region (GO:0098687) -4.190.032POT1, TERT