Disease table of SPINOCEREBELLAR ATAXIA OMIM ID: PS164400

Gene-disease associations table

Gene	Associated with SPINOCEREBELLAR ATAXIA in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
NOP56	ClinVar, OMIM	HGNC link	20p13	1	PS164400
TGM6	ClinVar, OMIM, HUMSAVAR	HGNC link	20p13	2	601626, PS164400
KCNC3	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.33	1	PS164400
SCYL1	ClinVar	HGNC link	11q13.1	2	PS164400, 616719
ATXN10	ClinVar, OMIM	HGNC link	22q13.31	1	PS164400
AFG3L2	ClinVar, OMIM, HUMSAVAR	HGNC link	18p11.21	2	PS164400, PS108600
SPTBN2	ClinVar, OMIM, HUMSAVAR	HGNC link	11q13.2	2	PS164400, 615386
CACNA1A	ClinVar, OMIM, HUMSAVAR	HGNC link	19p13.13	3	PS160120, 141500, PS164400
CCDC88C	ClinVar, OMIM, HUMSAVAR	HGNC link	14q32.12	2	236600, PS164400
CACNA1G	ClinVar, OMIM	HGNC link	17q21.33	1	PS164400
BEAN1	OMIM	HGNC link	16q21	1	PS164400
FGF14	ClinVar, OMIM, HUMSAVAR	HGNC link	13q33.1	1	PS164400
KCND3	ClinVar, OMIM, HUMSAVAR	HGNC link	1p13.2	2	PS601144, PS164400
PDYN	ClinVar, OMIM, HUMSAVAR	HGNC link	20p13	1	PS164400
TMEM240	ClinVar, OMIM, HUMSAVAR	HGNC link	1p36.33	1	PS164400
PRKCG	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.42	1	PS164400
PPP2R2B	ClinVar, OMIM	HGNC link	5q32	1	PS164400
ATXN8OS	ClinVar, OMIM	HGNC link	13q21.33	2	PS168600, PS164400
TTBK2	ClinVar, OMIM	HGNC link	15q15.2	1	PS164400
ITPR1	ClinVar, OMIM, HUMSAVAR	HGNC link	3p26.1	1	PS164400
PLEKHG4	ClinVar	HGNC link	16q22.1	1	PS164400
TRPC3	ClinVar, OMIM, HUMSAVAR	HGNC link	4q27	1	PS164400
TBP	ClinVar, OMIM	HGNC link	6q27	2	PS168600, PS164400
ELOVL4	ClinVar, OMIM, HUMSAVAR	HGNC link	6q14.1	3	PS164400, 614457, 600110
ELOVL5	ClinVar, OMIM, HUMSAVAR	HGNC link	6p12.1	1	PS164400
ATXN8	ClinVar, OMIM	HGNC link	13-	1	PS164400
ATXN7	ClinVar, OMIM	HGNC link	3p14.1	1	PS164400
ATXN2	ClinVar, OMIM	HGNC link	12q24.12	3	PS164400, PS168600, PS105400
ATXN3	ClinVar, OMIM	HGNC link	14q32.12	2	PS168600, PS164400
EEF2	ClinVar, OMIM, HUMSAVAR	HGNC link	19p13.3	1	PS164400
ATXN1	ClinVar, OMIM	HGNC link	6p22.3	1	PS164400

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
20p13	3	PDYN, NOP56, TGM6
14q32.12	2	ATXN3, CCDC88C

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
14q32	2	ATXN3, CCDC88C
20p13	3	PDYN, NOP56, TGM6
19q13	2	KCNC3, PRKCG
19p13	2	EEF2, CACNA1A
11q13	2	SPTBN2, SCYL1

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
19q1	2	KCNC3, PRKCG
20p1	3	PDYN, NOP56, TGM6
14q3	2	ATXN3, CCDC88C
19p1	2	EEF2, CACNA1A
16q2	2	BEAN1, PLEKHG4
11q1	2	SPTBN2, SCYL1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
20p	3	PDYN, NOP56, TGM6
13q	2	ATXN8OS, FGF14
1p	2	KCND3, TMEM240
14q	2	ATXN3, CCDC88C
3p	2	ITPR1, ATXN7
19q	2	KCNC3, PRKCG
19p	2	EEF2, CACNA1A
6p	2	ATXN1, ELOVL5
6q	2	ELOVL4, TBP
11q	2	SPTBN2, SCYL1
16q	2	BEAN1, PLEKHG4

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	2	SPTBN2, SCYL1
13	2	ATXN8OS, FGF14
20	3	PDYN, NOP56, TGM6
14	2	ATXN3, CCDC88C
16	2	BEAN1, PLEKHG4
19	4	EEF2, KCNC3, PRKCG, CACNA1A
1	2	KCND3, TMEM240
3	2	ITPR1, ATXN7
6	4	ELOVL5, ATXN1, ELOVL4, TBP

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
TBP	YES	13	CRP, BCL2, FUS, IGF1R, NF1, CDKN1A, IL6, PPBP, BDKRB1, MYC, FOS, LIN28B, APP	0

regulated gene	associated to this disease	# TFs	TFs
PDYN	YES	1	KCNIP3
PPP2R2B	YES	3	SP1, TFAP4, CREB1
TBP	YES	8	CREM, CDX1, BTAF1, TAF1, RELA, DR1, NFKB1, HNF4A
ATXN7	YES	1	CTCF
ATXN2	YES	2	ZNF350, ETS1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
NOP56	ATXN10	No	4	MYC, BSG, CUL3, CCDC8
NOP56	AFG3L2	No	1	CCDC8
NOP56	SPTBN2	No	3	OBSL1, ILF2, CCDC8
NOP56	CACNA1A	No	1	RPL31
NOP56	KCND3	No	1	NAP1L1
NOP56	PRKCG	No	2	IBTK, TOP2A
NOP56	PPP2R2B	No	3	CUL3, TOP1, TUFM
NOP56	TTBK2	No	1	COPS5
NOP56	TBP	No	9	MYC, USP10, SMARCA2, UBTF, GTF3C4, DHX9, ESR1, UBE2I, TAT
NOP56	ATXN7	No	2	UBE2I, NOC2L
NOP56	ATXN2	No	8	WWOX, TARDBP, RPL10, DHX15, CAND1, NXF1, CUL3, MOV10
NOP56	ATXN3	No	3	UBC, TUBA1A, MAP3K1
NOP56	EEF2	Yes	33	HNRNPA1, HSD17B10, TARDBP, RPS4X, NPM1, RPS6, RPL18, RPL10A, RPS7, RPL5, RPS15A, RPL6, ARRB2, COPS5, EEF1A1, ENO1, RPL21, RPS16, RPL4, RPS3A, RPL14, RPL11, RPL12, RPL7A, RPS24, RPL31, RPL7, CAND1, RPS5, RPS2, ESR1, RPL23, CUL3
NOP56	ATXN1	No	5	CIRBP, DHX37, UBE2I, U2AF2, PRRC2A
SCYL1	AFG3L2	No	2	NTRK1, APP
SCYL1	CCDC88C	No	1	APP
SCYL1	PDYN	No	1	APP
SCYL1	PRKCG	No	1	APP
SCYL1	PLEKHG4	No	1	COIL
SCYL1	TBP	No	1	REST
SCYL1	ELOVL5	No	1	SLC6A8
SCYL1	ATXN2	No	1	NTRK1
SCYL1	ATXN3	No	1	APP
SCYL1	EEF2	No	3	NTRK1, AURKA, XPO1
SCYL1	ATXN1	No	1	COIL
ATXN10	AFG3L2	No	5	CCDC8, EGFR, TNPO1, TUBA1C, TUBG1
ATXN10	SPTBN2	No	1	CCDC8
ATXN10	CACNA1A	No	1	GNB2
ATXN10	KCND3	No	1	HSPA8
ATXN10	PPP2R2B	No	1	CUL3
ATXN10	ITPR1	No	2	MAD2L1, VCP
ATXN10	TBP	No	2	MYC, GNB2
ATXN10	ATXN7	No	2	FN1, VCP
ATXN10	ATXN2	No	2	CUL3, EGFR
ATXN10	ATXN3	No	1	VCP
ATXN10	EEF2	No	3	FN1, HSPA8, CUL3
ATXN10	ATXN1	No	3	HSPA1A, HSPA8, VCP
AFG3L2	SPTBN2	No	1	CCDC8
AFG3L2	CACNA1A	No	1	UQCRC2
AFG3L2	CCDC88C	No	1	APP
AFG3L2	KCND3	No	1	UQCRC2
AFG3L2	PDYN	No	1	APP
AFG3L2	PRKCG	No	1	APP
AFG3L2	ITPR1	No	1	KCTD5
AFG3L2	TBP	No	1	NF2
AFG3L2	ATXN2	No	2	NTRK1, EGFR
AFG3L2	ATXN3	No	2	TMCO1, APP
AFG3L2	EEF2	No	3	NTRK1, HIPK4, RNF2
SPTBN2	PPP2R2B	No	1	MLH1
SPTBN2	ITPR1	No	4	CAPZA2, MYH9, SYNPO, MYO1C
SPTBN2	EEF2	No	1	MLH1
SPTBN2	ATXN1	No	1	MYO18A
CACNA1A	KCND3	No	1	UQCRC2
CACNA1A	PRKCG	No	1	NOXA1
CACNA1A	ITPR1	No	1	CABP1
CACNA1A	TBP	No	1	GNB2
CACNA1A	ATXN7	No	18	KALRN, NELL1, MEGF6, NELL2, GRN, ACTN1, LTBP4, PPP1R12C, MATN2, CRIM1, EFEMP1, SPRY1, AGRN, JAG2, MEGF8, VWF, LAMB1, EFEMP2
CACNA1A	ATXN2	No	3	GOLGA6L5P, KHDRBS3, ACTN1
CACNA1A	ATXN3	No	3	CSNK2B, UBE2L3, TUBB2B
CACNA1A	EEF2	No	1	RPL31
CACNA1A	ATXN1	No	5	MATN2, HIVEP1, PTGDS, EFEMP2, BTG3
CCDC88C	BEAN1	No	1	BAG3
CCDC88C	PDYN	No	1	APP
CCDC88C	PRKCG	No	1	APP
CCDC88C	ATXN3	No	2	APP, BAG3
CCDC88C	EEF2	No	1	SMURF1
CACNA1G	PRKCG	No	1	RANBP9
CACNA1G	ATXN1	No	1	UBQLN4
BEAN1	ATXN3	No	1	BAG3
KCND3	TBP	No	1	RUVBL1
KCND3	ATXN3	No	2	EWSR1, XRCC6
KCND3	EEF2	No	2	XRCC6, HSPA8
KCND3	ATXN1	No	1	HSPA8
PDYN	PRKCG	No	1	APP
PDYN	ATXN3	No	1	APP
PRKCG	ITPR1	No	1	SDC2
PRKCG	ATXN7	No	1	PICK1
PRKCG	ATXN3	No	3	PICK1, APP, SDC2
PRKCG	EEF2	No	1	HSP90AA1
PRKCG	ATXN1	No	1	HSPA4
PPP2R2B	TTBK2	No	1	MCM2
PPP2R2B	TBP	No	1	MCM2
PPP2R2B	ATXN2	No	2	CCT5, CUL3
PPP2R2B	EEF2	No	6	MLH1, CCT2, PPP2R1B, PPP2R1A, MCM2, CUL3
PPP2R2B	ATXN1	No	1	ATXN2L
TTBK2	TBP	No	1	MCM2
TTBK2	EEF2	No	3	MCM2, COPS5, PTEN
TTBK2	ATXN1	No	1	KLHL12
ITPR1	TRPC3	Yes	6	TRPC5, TRPC1, TRPC6, TRPC3, ITPR3, TRPC4
ITPR1	ATXN7	No	2	PSMD2, VCP
ITPR1	ATXN3	No	3	AMFR, SDC2, VCP
ITPR1	EEF2	No	1	ERLIN2
ITPR1	ATXN1	No	1	VCP
PLEKHG4	ATXN1	No	1	COIL
TBP	ELOVL5	No	1	ELAVL1
TBP	ATXN7	Yes	8	GOLGA2, TAF12, PSMC2, TBP, TAF10, TAF9, UBE2I, EP300
TBP	ATXN2	No	1	DDX5
TBP	ATXN3	No	3	CREBBP, EP300, HAP1
TBP	EEF2	No	7	DDX5, MDM2, MCM2, HUWE1, TP53, ESR1, EP300
TBP	ATXN1	No	4	UBE2I, REL, CREM, RNF4
ELOVL4	ELOVL5	No	1	CERS2
ATXN7	ATXN2	No	2	ACTN2, ACTN1
ATXN7	ATXN3	No	7	PICK1, SUMO1, VCP, RAD23A, PSMC5, TRIM54, EP300
ATXN7	EEF2	No	4	NUP62, RAD23A, EP300, FN1
ATXN7	ATXN1	No	9	PIAS1, VCP, SUMO1, MATN2, LRSAM1, RNF31, TRAF2, UBE2I, EFEMP2
ATXN2	ATXN3	No	1	PARK2
ATXN2	EEF2	No	8	DDX5, TARDBP, PABPC1, CAND1, SHFM1, ISG15, NTRK1, CUL3
ATXN2	ATXN1	Yes	3	RBFOX1, ATXN1, RBFOX2
ATXN3	EEF2	No	5	RPS6KA1, XRCC6, RAD23A, EP300, TUBB
ATXN3	ATXN1	No	5	VCP, NCOR1, STUB1, SUMO1, PML
EEF2	ATXN1	No	4	UNK, GSPT1, HSPA8, CRY2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
NOP56	ATXN10	No	-	1	UBC
NOP56	AFG3L2	No	-	1	UBC
NOP56	SPTBN2	No	-	1	UBC
NOP56	TTBK2	No	-	1	BYSL
NOP56	ITPR1	No	-	1	UBC
NOP56	TBP	No	-	6	RUVBL1, POLR1C, POLR1A, POLR1B, RUVBL2, UBC
NOP56	ELOVL5	No	-	1	UBC
NOP56	ATXN2	No	-	1	UBC
NOP56	ATXN3	No	-	1	UBC
NOP56	EEF2	No	-	8	RPL5, RPS7, RPS15A, RPS4X, RPS5, IMP3, RPS13, UBC
KCNC3	SPTBN2	No	-	2	KCNQ3, KCNQ2
KCNC3	KCND3	Yes	binding	38	KCNB2, KCNA7, KCND2, KCNH3, KCNC4, KCNAB1, KCNQ5, KCNG1, KCNH1, KCNS2, KCNA5, KCNA1, KCNH7, KCNG2, KCNH4, KCNS1, KCNAB2, KCNF1, KCNC1, KCNA10, KCNA3, KCNC2, KCNH8, KCNH5, KCNS3, KCNV2, KCNH6, KCNQ4, KCNB1, KCNAB3, KCNV1, KCNA2, KCNQ3, KCNG4, KCNG3, KCNA4, KCNA6, KCNQ2
ATXN10	AFG3L2	No	-	1	UBC
ATXN10	SPTBN2	No	-	1	UBC
ATXN10	ITPR1	No	-	1	UBC
ATXN10	TBP	No	-	1	UBC
ATXN10	ELOVL5	No	-	1	UBC
ATXN10	ATXN2	No	-	1	UBC
ATXN10	ATXN3	No	-	1	UBC
ATXN10	EEF2	No	-	1	UBC
AFG3L2	SPTBN2	No	-	1	UBC
AFG3L2	ITPR1	No	-	1	UBC
AFG3L2	TBP	No	-	1	UBC
AFG3L2	ELOVL5	No	-	1	UBC
AFG3L2	ATXN2	No	-	1	UBC
AFG3L2	ATXN3	No	-	1	UBC
AFG3L2	EEF2	No	-	1	UBC
SPTBN2	CACNA1G	No	-	1	NCAM1
SPTBN2	KCND3	No	-	2	KCNQ3, KCNQ2
SPTBN2	PRKCG	No	-	2	HRAS, PTK2
SPTBN2	ITPR1	No	-	3	UBC, FYN, ANK1
SPTBN2	TBP	No	-	1	UBC
SPTBN2	ELOVL5	No	-	1	UBC
SPTBN2	ATXN2	No	-	1	UBC
SPTBN2	ATXN3	No	-	1	UBC
SPTBN2	EEF2	No	-	1	UBC
CCDC88C	PDYN	No	-	1	GNAI3
CCDC88C	PRKCG	No	-	1	GNAI3
CACNA1G	PPP2R2B	No	-	14	CACNA1S, CACNA2D4, CACNG6, CACNB1, CACNG8, CACNG1, CACNG2, CACNG3, CACNA2D1, CACNB2, CACNG7, CACNB4, CACNB3, CACNA1D
KCND3	PRKCG	No	-	1	SRC
KCND3	ITPR1	No	-	1	SRC
KCND3	TRPC3	No	-	1	SRC
PDYN	PRKCG	No	-	4	GNAO1, GNAI3, CREB1, GNG2
PDYN	PPP2R2B	No	-	1	DRD2
PDYN	TRPC3	No	-	1	CASR
PDYN	ATXN1	No	-	1	DRD2
PRKCG	PPP2R2B	No	-	8	RAF1, BRAF, PPP2CA, YWHAG, PPP2R1B, PPP2CB, PPP2R1A, YWHAB
PRKCG	ITPR1	No	-	3	SRC, LYN, RHOA
PRKCG	TRPC3	No	-	3	SRC, PLCG1, EZR
PRKCG	TBP	No	-	4	CLOCK, ATF4, FOS, TTF1
PRKCG	EEF2	No	-	3	EEF2K, MTOR, EGLN1
PPP2R2B	ITPR1	No	-	2	CDK1, AKT1
PPP2R2B	TBP	No	-	1	RELA
PPP2R2B	ATXN1	No	-	4	DRD2, YWHAE, AKT1, YWHAZ
ITPR1	TRPC3	Yes	binding	8	TRPC5, TRPC1, TRPC6, ITPR3, GNB2L1, TRPC4, SRC, ITPR2
ITPR1	TBP	No	-	1	UBC
ITPR1	ELOVL5	No	-	1	UBC
ITPR1	ATXN7	No	-	1	HTT
ITPR1	ATXN2	No	-	1	UBC
ITPR1	ATXN3	No	-	2	DERL1, UBC
ITPR1	EEF2	No	-	1	UBC
ITPR1	ATXN1	No	-	1	AKT1
PLEKHG4	ATXN1	No	-	1	COIL
TBP	ELOVL5	No	-	1	UBC
TBP	ATXN7	Yes	binding	17	KAT2B, KAT2A, TAF12, TAF6, EP300, TAF10, TAF6L, TAF5L, TRRAP, TAF1, TADA2B, TADA3, TAF9, TAF5, TADA2A, TAF1L, SUPT3H
TBP	ATXN2	No	-	1	UBC
TBP	ATXN3	No	-	2	UBC, CREBBP
TBP	EEF2	No	-	4	UBC, MAPK14, POLR2B, TP53
ELOVL4	ELOVL5	No	-	3	TECR, TECRL, CERS2
ELOVL5	ATXN2	No	-	1	UBC
ELOVL5	ATXN3	No	-	1	UBC
ELOVL5	EEF2	No	-	1	UBC
ATXN2	ATXN3	No	-	1	UBC
ATXN2	EEF2	No	-	2	UBC, PABPC1
ATXN2	ATXN1	Yes	binding	1	RBFOX2
ATXN3	EEF2	No	-	2	UBC, RPS27A
ATXN3	ATXN1	No	-	2	STUB1, SUMO1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
NOP56	TBP	No	-	1	DHX9
NOP56	EEF2	Yes	Nop56p-associated pre-rRNA complex	103	RPL18A, ILF3, RPS12, RPL27, RPL28, RPL6, RPL29, RPL5, LYAR, DHX9, RPL12, EEF1A1, TOP1, HIST1H1D, RPL32, RPL4, RPL15, RPL11, RPLP2, FBL, RPS18, DDX21, GNL3, RPS13, RPL39, RPL7, HIST1H2BM, HNRNPA1, RPL17, RPS8, SLC25A5, RPL36A, RPLP1, RPS15A, RSL1D1, RPL8, RPL35, ACTG2, RPS14, RPS16, RPLP0, RPS17, LUC7L2, RPL24, RPL13A, SNU13, RPL7A, RPS24, TUBB1, RPL27A, PWP1, HNRNPM, RPL31, SCYL2, RPL30, TCOF1, RPS7, U2AF1, NOLC1, RPL10, RPS6, RPL19, RPL23, RPL36, TUBA1A, RPL26, MYBBP1A, ILF2, RPL14, RPS23, RPL9; RPL9P7; RPL9P8; RPL9P9, RPL3, U2AF2, TUFM, RPS3A, HNRNPU, RPS15, NOP58, EBNA1BP2, RPS11, RPS29, RPS9, YBX1, IGF2BP1, BRIX1, ACTA2, NPM1, RPL9, RPL13, NCL, RPL35A, RPL21, RPL10A, SRPK1, RPL23A, RPL37A, SRP14, RPL22, H1FX, RBM28, NAP1L1, RPL18, RPS2
SCYL1	TBP	No	-	6	SMARCC1, SMARCB1, ACTB, SMARCC2, SMARCA4, SMARCD1
ITPR1	TRPC3	No	-	1	TRPC1
TBP	ATXN7	No	-	10	TAF6, TAF12, TAF4, TAF7, TAF10, TAF9, TAF13, TAF5, TAF9B, TAF2
TBP	EEF2	No	-	1	DHX9

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
NOP56	EEF2	No	15	RPL18, RPS7, RPL5, RPS24, RPL31, RPS4X, RPL4, RPS5, RPL6, RPS6, RPL11, RPS2, EEF1A1, RPS15A, RPL7

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Dopaminergic synapse	hsa04728	5.69	4	CACNA1A, PPP2R2B, ITPR1, PRKCG
Calcium signaling pathway	hsa04020	5.22	4	CACNA1A, CACNA1G, ITPR1, PRKCG
MAPK signaling pathway	hsa04010	4.63	4	CACNA1A, CACNA1G, FGF14, PRKCG
Retrograde endocannabinoid signaling	hsa04723	6.03	3	CACNA1A, ITPR1, PRKCG
Cholinergic synapse	hsa04725	5.88	3	CACNA1A, ITPR1, PRKCG
Oxytocin signaling pathway	hsa04921	5.4	3	EEF2, ITPR1, PRKCG
Serotonergic synapse	hsa04726	5.84	3	CACNA1A, ITPR1, PRKCG
Circadian entrainment	hsa04713	6.11	3	CACNA1G, ITPR1, PRKCG
Long-term depression	hsa04730	6.74	3	CACNA1A, ITPR1, PRKCG
Glutamatergic synapse	hsa04724	5.84	3	CACNA1A, ITPR1, PRKCG
Tight junction	hsa04530	5.53	2	PPP2R2B, PRKCG
Long-term potentiation	hsa04720	6.64	2	ITPR1, PRKCG
GABAergic synapse	hsa04727	6.24	2	CACNA1A, PRKCG
Fatty acid elongation	hsa00062	8.18	2	ELOVL4, ELOVL5
Type II diabetes mellitus	hsa04930	7.12	2	CACNA1A, CACNA1G
Vascular smooth muscle contraction	hsa04270	5.74	2	ITPR1, PRKCG
Gap junction	hsa04540	6.24	2	ITPR1, PRKCG
Proteoglycans in cancer	hsa05205	5.02	2	ITPR1, PRKCG
Pathways in cancer	hsa05200	3.98	2	FGF14, PRKCG
Phosphatidylinositol signaling system	hsa04070	6.38	2	ITPR1, PRKCG
Rap1 signaling pathway	hsa04015	4.97	2	FGF14, PRKCG
Ras signaling pathway	hsa04014	4.9	2	FGF14, PRKCG
Inflammatory mediator regulation of TRP channels	hsa04750	6.07	2	ITPR1, PRKCG
Thyroid hormone synthesis	hsa04918	6.56	2	ITPR1, PRKCG
AMPK signaling pathway	hsa04152	5.8	2	PPP2R2B, EEF2
PI3K-Akt signaling pathway	hsa04151	4.21	2	PPP2R2B, FGF14
Salivary secretion	hsa04970	6.23	2	ITPR1, PRKCG
Gastric acid secretion	hsa04971	6.48	2	ITPR1, PRKCG
Pancreatic secretion	hsa04972	6.07	2	ITPR1, PRKCG
Morphine addiction	hsa05032	6.15	2	CACNA1A, PRKCG
Amphetamine addiction	hsa05031	6.62	2	PRKCG, PDYN
Huntington's disease	hsa05016	5.17	2	TBP, ITPR1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Dopaminergic synapse (hsa04728)	-	5.69	0.009	CACNA1A, PPP2R2B, ITPR1, PRKCG
Calcium signaling pathway (hsa04020)	-	5.22	0.033	CACNA1A, CACNA1G, ITPR1, PRKCG
Long-term depression (hsa04730)	-	6.74	0.027	CACNA1A, TRPC3, ITPR1, PRKCG
MAPK signaling pathway (hsa04010)	-	4.63	0.041	CACNA1A, TBP, FGF14, ATXN1, CACNA1G, ITPR1, PRKCG

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Signal Transduction	R-HSA-162582	1.78	6	CCDC88C, SPTBN2, TRPC3, PDYN, ITPR1, PRKCG
Signaling by GPCR	R-HSA-372790	2.68	5	TRPC3, SPTBN2, ITPR1, PRKCG, PDYN
Neuronal System	R-HSA-112316	4.82	4	CACNA1A, KCND3, KCNC3, PRKCG
GPCR downstream signaling	R-HSA-388396	3.07	4	TRPC3, ITPR1, PRKCG, PDYN
Metabolism	R-HSA-1430728	2.34	4	CACNA1A, ELOVL4, ITPR1, ELOVL5
Immune System	R-HSA-168256	2.37	3	ITPR1, PRKCG, SPTBN2
Downstream signal transduction	R-HSA-186763	4.65	3	ITPR1, PRKCG, SPTBN2
Developmental Biology	R-HSA-1266738	3.48	3	TRPC3, CACNA1G, SPTBN2
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	3	ITPR1, PRKCG, SPTBN2
Signalling by NGF	R-HSA-166520	4.23	3	ITPR1, PRKCG, SPTBN2
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	3	TRPC3, ITPR1, PRKCG
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	3	TRPC3, ITPR1, SPTBN2
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	3	ITPR1, PRKCG, SPTBN2
Signaling by FGFR4	R-HSA-5654743	4.69	3	ITPR1, PRKCG, SPTBN2
Signaling by FGFR3	R-HSA-5654741	4.69	3	ITPR1, PRKCG, SPTBN2
Signaling by FGFR	R-HSA-190236	4.67	3	ITPR1, PRKCG, SPTBN2
Innate Immune System	R-HSA-168249	3.17	3	ITPR1, PRKCG, SPTBN2
Signaling by PDGF	R-HSA-186797	4.53	3	ITPR1, PRKCG, SPTBN2
DAP12 signaling	R-HSA-2424491	4.64	3	ITPR1, PRKCG, SPTBN2
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	3	ITPR1, PRKCG, SPTBN2
Signaling by EGFR	R-HSA-177929	4.59	3	ITPR1, PRKCG, SPTBN2
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	3	ITPR1, PRKCG, SPTBN2
Signaling by Wnt	R-HSA-195721	4.79	3	CCDC88C, ITPR1, PRKCG
Signaling by FGFR2	R-HSA-5654738	4.68	3	ITPR1, PRKCG, SPTBN2
Signaling by FGFR1	R-HSA-5654736	4.69	3	ITPR1, PRKCG, SPTBN2
Opioid Signalling	R-HSA-111885	6.64	3	ITPR1, PRKCG, PDYN
DAP12 interactions	R-HSA-2172127	4.56	3	ITPR1, PRKCG, SPTBN2
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	3	ITPR1, PRKCG, SPTBN2
Signaling by ERBB2	R-HSA-1227986	4.66	3	ITPR1, PRKCG, SPTBN2
Axon guidance	R-HSA-422475	3.93	3	TRPC3, CACNA1G, SPTBN2
Hemostasis	R-HSA-109582	3.98	3	TRPC3, ITPR1, PRKCG
Phospholipase C-mediated cascade; FGFR2	R-HSA-5654221	7.37	2	ITPR1, PRKCG
PLCG1 events in ERBB2 signaling	R-HSA-1251932	7.85	2	ITPR1, PRKCG
DAG and IP3 signaling	R-HSA-1489509	7.98	2	ITPR1, PRKCG
Phospholipase C-mediated cascade; FGFR3	R-HSA-5654227	7.52	2	ITPR1, PRKCG
Phospholipase C-mediated cascade; FGFR4	R-HSA-5654228	7.46	2	ITPR1, PRKCG
Fatty acid, triacylglycerol, and ketone body metabolism	R-HSA-535734	5.44	2	ELOVL4, ELOVL5
Effects of PIP2 hydrolysis	R-HSA-114508	8.34	2	TRPC3, ITPR1
Disease	R-HSA-1643685	3.33	2	TBP, EEF2
Signaling by VEGF	R-HSA-194138	4.66	2	ITPR1, SPTBN2
Gene Expression	R-HSA-74160	2.72	2	TBP, EEF2
Platelet calcium homeostasis	R-HSA-418360	8.73	2	TRPC3, ITPR1
Adaptive Immune System	R-HSA-1280218	3.19	2	ITPR1, SPTBN2
Phospholipase C-mediated cascade: FGFR1	R-HSA-5654219	7.43	2	ITPR1, PRKCG
Platelet homeostasis	R-HSA-418346	6.68	2	TRPC3, ITPR1
Elevation of cytosolic Ca2+ levels	R-HSA-139853	9.81	2	TRPC3, ITPR1
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79	2	ELOVL4, ELOVL5
Transmission across Chemical Synapses	R-HSA-112315	5.28	2	CACNA1A, PRKCG
Infectious disease	R-HSA-5663205	4.47	2	TBP, EEF2
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	2	ITPR1, SPTBN2
Voltage gated Potassium channels	R-HSA-1296072	7.56	2	KCND3, KCNC3
Triglyceride Biosynthesis	R-HSA-75109	7.46	2	ELOVL4, ELOVL5
Potassium Channels	R-HSA-1296071	6.35	2	KCND3, KCNC3
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	2	ITPR1, SPTBN2
Fatty Acyl-CoA Biosynthesis	R-HSA-75105	8.34	2	ELOVL4, ELOVL5
beta-catenin independent WNT signaling	R-HSA-3858494	5.83	2	ITPR1, PRKCG
Integration of energy metabolism	R-HSA-163685	6.24	2	CACNA1A, ITPR1
Metabolism of proteins	R-HSA-392499	3.41	2	EEF2, NOP56
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	2	CACNA1G, SPTBN2
PLC-gamma1 signalling	R-HSA-167021	7.89	2	ITPR1, PRKCG
EGFR interacts with phospholipase C-gamma	R-HSA-212718	7.89	2	ITPR1, PRKCG
Regulation of insulin secretion	R-HSA-422356	6.66	2	CACNA1A, ITPR1
PLC beta mediated events	R-HSA-112043	7.52	2	ITPR1, PRKCG
G-protein mediated events	R-HSA-112040	7.49	2	ITPR1, PRKCG
G alpha (q) signalling events	R-HSA-416476	5.42	2	TRPC3, ITPR1
Synthesis of very long-chain fatty acyl-CoAs	R-HSA-75876	8.66	2	ELOVL4, ELOVL5
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	2	ITPR1, SPTBN2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Elevation of cytosolic Ca2+ levels (R-HSA-139853)	-	9.81	0.029	TRPC3, ITPR1

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	26	CCDC88C, TBP, ATXN1, ELOVL4, ATXN10, FGF14, EEF2, PRKCG, ATXN7, TGM6, KCND3, PLEKHG4, CACNA1A, SPTBN2, TRPC3, PDYN, TTBK2, ITPR1, PPP2R2B, ATXN2, AFG3L2, SCYL1, CACNA1G, ELOVL5, ATXN3, NOP56
protein binding (GO:0005515)	0.46	23	CCDC88C, TBP, ELOVL4, EEF2, FGF14, ATXN10, ATXN3, KCND3, ATXN7, PLEKHG4, CACNA1A, SPTBN2, TRPC3, PDYN, TTBK2, ITPR1, PPP2R2B, ATXN2, AFG3L2, ATXN1, CACNA1G, ELOVL5, NOP56
organic cyclic compound binding (GO:0097159)	1.05	10	ATXN2, TBP, ATXN1, AFG3L2, SCYL1, NOP56, TTBK2, ATXN3, EEF2, PRKCG
heterocyclic compound binding (GO:1901363)	1.06	10	ATXN2, TBP, ATXN1, AFG3L2, SCYL1, NOP56, TTBK2, ATXN3, EEF2, PRKCG
catalytic activity (GO:0003824)	1.05	9	AFG3L2, SCYL1, ELOVL5, ELOVL4, EEF2, TTBK2, ATXN3, TGM6, PRKCG
nucleic acid binding (GO:0003676)	1.44	7	ATXN2, TBP, ATXN1, SCYL1, NOP56, EEF2, ATXN3
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
substrate-specific transporter activity (GO:0022892)	2.72	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
cation channel activity (GO:0005261)	4.04	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
carbohydrate derivative binding (GO:0097367)	2.03	6	AFG3L2, SCYL1, EEF2, FGF14, TTBK2, PRKCG
transporter activity (GO:0005215)	2.57	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
ion channel activity (GO:0005216)	3.71	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
cation transmembrane transporter activity (GO:0008324)	3.32	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
transmembrane transporter activity (GO:0022857)	2.82	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
ion transmembrane transporter activity (GO:0015075)	3.04	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
transferase activity (GO:0016740)	1.95	6	TGM6, SCYL1, ELOVL4, ELOVL5, TTBK2, PRKCG
channel activity (GO:0015267)	3.6	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
small molecule binding (GO:0036094)	1.89	6	AFG3L2, SCYL1, TRPC3, EEF2, TTBK2, PRKCG
passive transmembrane transporter activity (GO:0022803)	3.6	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
metal ion transmembrane transporter activity (GO:0046873)	3.71	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
substrate-specific channel activity (GO:0022838)	3.67	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
cation binding (GO:0043169)	1.4	5	CACNA1A, KCND3, TGM6, AFG3L2, PRKCG
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	5	SCYL1, TTBK2, PRKCG, AFG3L2, EEF2
enzyme binding (GO:0019899)	2.27	5	TBP, ATXN3, ATXN10, NOP56, EEF2
nucleotide binding (GO:0000166)	1.96	5	SCYL1, TTBK2, PRKCG, AFG3L2, EEF2
ion binding (GO:0043167)	1.36	5	CACNA1A, KCND3, TGM6, AFG3L2, PRKCG
nucleoside binding (GO:0001882)	2.21	5	TTBK2, EEF2, SCYL1, AFG3L2, PRKCG
ribonucleotide binding (GO:0032553)	2.19	5	SCYL1, TTBK2, PRKCG, AFG3L2, EEF2
purine nucleoside binding (GO:0001883)	2.22	5	TTBK2, EEF2, SCYL1, AFG3L2, PRKCG
ribonucleoside binding (GO:0032549)	2.22	5	SCYL1, TTBK2, PRKCG, AFG3L2, EEF2
purine ribonucleotide binding (GO:0032555)	2.2	5	SCYL1, TTBK2, PRKCG, AFG3L2, EEF2
purine nucleotide binding (GO:0017076)	2.19	5	SCYL1, TTBK2, PRKCG, AFG3L2, EEF2
metal ion binding (GO:0046872)	1.41	5	CACNA1A, KCND3, TGM6, AFG3L2, PRKCG
purine ribonucleoside binding (GO:0032550)	2.22	5	SCYL1, TTBK2, PRKCG, AFG3L2, EEF2
nucleoside phosphate binding (GO:1901265)	1.96	5	TTBK2, EEF2, SCYL1, AFG3L2, PRKCG
gated channel activity (GO:0022836)	3.96	5	CACNA1A, KCNC3, KCND3, CACNA1G, ITPR1
calcium ion transmembrane transporter activity (GO:0015085)	4.89	4	CACNA1A, CACNA1G, ITPR1, TRPC3
voltage-gated ion channel activity (GO:0005244)	4.49	4	CACNA1A, CACNA1G, KCND3, KCNC3
calcium channel activity (GO:0005262)	5.03	4	CACNA1A, TRPC3, CACNA1G, ITPR1
adenyl nucleotide binding (GO:0030554)	2.4	4	TTBK2, SCYL1, AFG3L2, PRKCG
divalent inorganic cation transmembrane transporter activity (GO:0072509)	4.62	4	CACNA1A, TRPC3, CACNA1G, ITPR1
voltage-gated channel activity (GO:0022832)	4.49	4	CACNA1A, CACNA1G, KCND3, KCNC3
adenyl ribonucleotide binding (GO:0032559)	2.41	4	TTBK2, SCYL1, AFG3L2, PRKCG
RNA binding (GO:0003723)	2.36	4	ATXN1, EEF2, NOP56, ATXN2
DNA binding (GO:0003677)	1.92	4	TBP, ATXN3, SCYL1, ATXN1
molecular function regulator (GO:0098772)	2.51	4	PPP2R2B, ITPR1, PLEKHG4, SPTBN2
ATP binding (GO:0005524)	2.43	4	TTBK2, SCYL1, AFG3L2, PRKCG
voltage-gated cation channel activity (GO:0022843)	4.83	4	CACNA1A, CACNA1G, KCND3, KCNC3
hydrolase activity (GO:0016787)	1.9	3	AFG3L2, ATXN3, EEF2
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	3	TTBK2, SCYL1, PRKCG
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	3	TTBK2, SCYL1, PRKCG
poly(A) RNA binding (GO:0044822)	2.69	3	EEF2, NOP56, ATXN2
kinase activity (GO:0016301)	2.93	3	TTBK2, SCYL1, PRKCG
protein kinase activity (GO:0004672)	3.27	3	TTBK2, SCYL1, PRKCG
receptor binding (GO:0005102)	2.43	3	FGF14, PDYN, ATXN2
identical protein binding (GO:0042802)	2.63	3	ATXN1, ATXN10, ATXN3
Ras guanyl-nucleotide exchange factor activity (GO:0005088)	4.31	2	PLEKHG4, SPTBN2
potassium channel activity (GO:0005267)	4.94	2	KCND3, KCNC3
signaling receptor activity (GO:0038023)	2.49	2	ELOVL4, ITPR1
RNA polymerase II regulatory region DNA binding (GO:0001012)	3.36	2	TBP, ATXN3
protein C-terminus binding (GO:0008022)	4.5	2	ATXN1, ATXN2
molecular transducer activity (GO:0060089)	2.32	2	ELOVL4, ITPR1
macromolecular complex binding (GO:0044877)	2.61	2	EEF2, ATXN7
zinc ion binding (GO:0008270)	2.66	2	AFG3L2, PRKCG
signal transducer activity (GO:0004871)	2.28	2	ELOVL4, ITPR1
peptidase activity (GO:0008233)	3.23	2	AFG3L2, ATXN3
transition metal ion binding (GO:0046914)	2.48	2	AFG3L2, PRKCG
phospholipid binding (GO:0005543)	3.91	2	ITPR1, SPTBN2
transmembrane signaling receptor activity (GO:0004888)	2.57	2	ELOVL4, ITPR1
structural molecule activity (GO:0005198)	3.1	2	TTBK2, SPTBN2
actin binding (GO:0003779)	3.74	2	EEF2, SPTBN2
protein serine/threonine kinase activity (GO:0004674)	3.64	2	TTBK2, PRKCG
transferase activity, transferring acyl groups (GO:0016746)	4.2	2	ELOVL5, TGM6
delayed rectifier potassium channel activity (GO:0005251)	6.15	2	KCND3, KCNC3
guanyl-nucleotide exchange factor activity (GO:0005085)	4.02	2	PLEKHG4, SPTBN2
regulatory region nucleic acid binding (GO:0001067)	3.03	2	TBP, ATXN3
lipid binding (GO:0008289)	3.26	2	ITPR1, SPTBN2
nucleoside-triphosphatase activity (GO:0017111)	3.09	2	AFG3L2, EEF2
protein self-association (GO:0043621)	5.93	2	CCDC88C, ATXN1
transcription regulatory region DNA binding (GO:0044212)	3.03	2	TBP, ATXN3
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	2	AFG3L2, EEF2
cytoskeletal protein binding (GO:0008092)	3.02	2	EEF2, SPTBN2
growth factor receptor binding (GO:0070851)	4.87	2	FGF14, ATXN2
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	2	AFG3L2, EEF2
pyrophosphatase activity (GO:0016462)	3.04	2	AFG3L2, EEF2
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3.87	2	KCND3, KCNC3
peptidase activity, acting on L-amino acid peptides (GO:0070011)	3.26	2	AFG3L2, ATXN3
voltage-gated potassium channel activity (GO:0005249)	5.24	2	KCND3, KCNC3
regulatory region DNA binding (GO:0000975)	3.03	2	TBP, ATXN3
voltage-gated calcium channel activity (GO:0005245)	6.0	2	CACNA1A, CACNA1G
potassium ion transmembrane transporter activity (GO:0015079)	4.77	2	KCND3, KCNC3
transmembrane receptor activity (GO:0099600)	2.53	2	ELOVL4, ITPR1
receptor activity (GO:0004872)	2.32	2	ELOVL4, ITPR1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
calcium ion transmembrane transporter activity (GO:0015085)	-	4.89	0.008	TRPC3, CACNA1G, ITPR1, CACNA1A
voltage-gated ion channel activity (GO:0005244)	-	4.49	0.031	CACNA1A, CACNA1G, KCND3, KCNC3
cation channel activity (GO:0005261)	-	4.04	0.001	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
substrate-specific channel activity (GO:0022838)	-	3.67	0.006	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
calcium channel activity (GO:0005262)	-	5.03	0.004	CACNA1A, TRPC3, CACNA1G, ITPR1
ion channel activity (GO:0005216)	-	3.71	0.006	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
cation transmembrane transporter activity (GO:0008324)	-	3.32	0.041	CACNA1A, TRPC3, ATXN1, SCYL1, KCNC3, CACNA1G, KCND3, ITPR1, PRKCG
divalent inorganic cation transmembrane transporter activity (GO:0072509)	-	4.62	0.029	TRPC3, CACNA1G, ITPR1, CACNA1A, PRKCG
voltage-gated channel activity (GO:0022832)	-	4.49	0.031	CACNA1A, CACNA1G, KCND3, KCNC3
channel activity (GO:0015267)	-	3.6	0.008	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
voltage-gated cation channel activity (GO:0022843)	-	4.83	0.013	CACNA1A, CACNA1G, KCND3, KCNC3
channel regulator activity (GO:0016247)	NEW	4.88	0.02	TRPC3, ATXN1, KCND3, ITPR1, ATXN2
passive transmembrane transporter activity (GO:0022803)	-	3.6	0.008	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
metal ion transmembrane transporter activity (GO:0046873)	-	3.71	0.011	CACNA1A, TRPC3, ATXN1, KCNC3, CACNA1G, KCND3, ITPR1, PRKCG
inorganic cation transmembrane transporter activity (GO:0022890)	-	3.49	0.019	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
receptor binding (GO:0005102)	-	2.43	0.002	CACNA1A, TRPC3, SCA7, ATXN2, TBP, ATXN3, AFG3L2, ATXN1, FGF14, CACNA1G, ELOVL5, NOP56, PDYN, EEF2, ITPR1, PRKCG
gated channel activity (GO:0022836)	-	3.96	0.002	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1, PRKCG

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	26	CCDC88C, ATXN1, TBP, SCYL1, ELOVL4, ATXN10, FGF14, EEF2, PRKCG, ATXN7, TGM6, KCND3, CACNA1A, SPTBN2, TRPC3, PDYN, TTBK2, ITPR1, PPP2R2B, ATXN2, AFG3L2, KCNC3, CACNA1G, ELOVL5, ATXN3, NOP56
biological regulation (GO:0065007)	0.39	22	CCDC88C, SCYL1, TBP, KCNC3, EEF2, FGF14, PRKCG, ATXN3, ATXN7, PLEKHG4, CACNA1A, SPTBN2, TRPC3, PDYN, TTBK2, ITPR1, PPP2R2B, ATXN2, AFG3L2, ATXN1, CACNA1G, KCND3
regulation of biological process (GO:0050789)	0.45	22	CCDC88C, SCYL1, TBP, KCNC3, EEF2, FGF14, PRKCG, ATXN3, ATXN7, PLEKHG4, CACNA1A, SPTBN2, TRPC3, PDYN, TTBK2, ITPR1, PPP2R2B, ATXN2, AFG3L2, ATXN1, CACNA1G, KCND3
single-organism process (GO:0044699)	0.48	20	CACNA1A, PPP2R2B, ITPR1, TRPC3, FGF14, TBP, ATXN7, AFG3L2, ATXN10, KCNC3, KCND3, SPTBN2, CACNA1G, ELOVL5, EEF2, PDYN, TTBK2, ATXN3, ELOVL4, PRKCG
single-organism cellular process (GO:0044763)	0.65	19	CACNA1A, PPP2R2B, ITPR1, TRPC3, FGF14, ELOVL5, AFG3L2, KCNC3, ELOVL4, SPTBN2, CACNA1G, KCND3, ATXN3, EEF2, PDYN, ATXN10, ATXN7, TTBK2, PRKCG
regulation of cellular process (GO:0050794)	0.5	19	CCDC88C, TRPC3, ATXN1, PDYN, ATXN2, TBP, ATXN7, SCYL1, CACNA1A, PPP2R2B, CACNA1G, FGF14, ATXN3, SPTBN2, PLEKHG4, TTBK2, ITPR1, EEF2, PRKCG
organic substance metabolic process (GO:0071704)	0.63	17	CACNA1A, ATXN1, ATXN2, TBP, ATXN7, TGM6, SCYL1, ELOVL5, SPTBN2, ELOVL4, NOP56, EEF2, FGF14, TTBK2, ATXN3, AFG3L2, PRKCG
metabolic process (GO:0008152)	0.58	17	CACNA1A, ATXN2, TBP, ATXN1, TGM6, SCYL1, ELOVL5, SPTBN2, FGF14, ELOVL4, ATXN3, NOP56, EEF2, TTBK2, ATXN7, AFG3L2, PRKCG
cellular metabolic process (GO:0044237)	0.69	17	CACNA1A, ATXN1, ATXN2, TBP, ATXN7, TGM6, SCYL1, ELOVL4, SPTBN2, ELOVL5, NOP56, EEF2, FGF14, TTBK2, ATXN3, AFG3L2, PRKCG
primary metabolic process (GO:0044238)	0.69	17	CACNA1A, ATXN2, TBP, ATXN1, TGM6, SCYL1, ELOVL5, SPTBN2, FGF14, ELOVL4, ATXN3, NOP56, EEF2, TTBK2, ATXN7, AFG3L2, PRKCG
cellular macromolecule metabolic process (GO:0044260)	0.93	14	ATXN1, ATXN2, TBP, ATXN7, TGM6, SCYL1, SPTBN2, NOP56, EEF2, FGF14, TTBK2, ATXN3, AFG3L2, PRKCG
macromolecule metabolic process (GO:0043170)	0.83	14	ATXN2, TBP, SCYL1, TGM6, ATXN1, SPTBN2, FGF14, ATXN3, NOP56, EEF2, TTBK2, ATXN7, AFG3L2, PRKCG
response to stimulus (GO:0050896)	1.22	13	CACNA1A, CCDC88C, ITPR1, AFG3L2, ELOVL4, SPTBN2, TRPC3, CACNA1G, KCND3, FGF14, EEF2, ATXN3, PRKCG
localization (GO:0051179)	1.4	12	CACNA1A, CACNA1G, ATXN1, ATXN2, ATXN3, AFG3L2, SCYL1, KCNC3, SPTBN2, TRPC3, KCND3, ITPR1
cellular component organization or biogenesis (GO:0071840)	1.22	12	CCDC88C, CACNA1A, ATXN2, ATXN7, AFG3L2, KCNC3, SPTBN2, KCND3, NOP56, TTBK2, ATXN3, ATXN10
transport (GO:0006810)	1.51	11	CACNA1A, TRPC3, ATXN1, ATXN2, SCYL1, AFG3L2, KCNC3, SPTBN2, CACNA1G, KCND3, ITPR1
establishment of localization (GO:0051234)	1.48	11	CACNA1A, CACNA1G, ATXN1, ATXN2, SCYL1, AFG3L2, KCNC3, SPTBN2, TRPC3, KCND3, ITPR1
regulation of cellular metabolic process (GO:0031323)	1.07	11	CCDC88C, CACNA1A, ATXN1, ATXN2, TBP, ATXN3, SCYL1, PPP2R2B, EEF2, ATXN7, PRKCG
cellular component organization (GO:0016043)	1.24	11	CACNA1A, CCDC88C, ATXN2, ATXN3, AFG3L2, KCNC3, SPTBN2, KCND3, ATXN10, ATXN7, TTBK2
regulation of metabolic process (GO:0019222)	1.02	11	CCDC88C, CACNA1A, ATXN1, ATXN2, TBP, ATXN3, SCYL1, PPP2R2B, EEF2, ATXN7, PRKCG
protein metabolic process (GO:0019538)	1.45	10	FGF14, ATXN3, AFG3L2, SCYL1, SPTBN2, EEF2, TTBK2, ATXN7, TGM6, PRKCG
cellular protein metabolic process (GO:0044267)	1.63	10	FGF14, ATXN3, AFG3L2, SCYL1, SPTBN2, EEF2, TTBK2, ATXN7, TGM6, PRKCG
macromolecule modification (GO:0043412)	1.73	10	ATXN3, TGM6, SCYL1, SPTBN2, NOP56, FGF14, TTBK2, ATXN7, EEF2, PRKCG
regulation of macromolecule metabolic process (GO:0060255)	1.08	10	CCDC88C, ATXN1, ATXN2, TBP, ATXN3, SCYL1, PPP2R2B, EEF2, ATXN7, PRKCG
regulation of primary metabolic process (GO:0080090)	1.08	10	CCDC88C, ATXN1, ATXN2, TBP, ATXN3, SCYL1, PPP2R2B, EEF2, ATXN7, PRKCG
multicellular organismal process (GO:0032501)	1.45	9	CACNA1A, ITPR1, SPTBN2, CACNA1G, KCND3, PDYN, EEF2, ATXN7, PRKCG
cellular component assembly (GO:0022607)	2.14	9	CACNA1A, CCDC88C, ATXN2, AFG3L2, KCNC3, SPTBN2, KCND3, TTBK2, ATXN10
regulation of biological quality (GO:0065008)	1.68	9	CACNA1A, CCDC88C, TRPC3, FGF14, SPTBN2, CACNA1G, KCND3, TTBK2, ITPR1
regulation of transport (GO:0051049)	2.24	9	CACNA1A, TRPC3, ATXN2, FGF14, KCNC3, CACNA1G, KCND3, ITPR1, PRKCG
cellular protein modification process (GO:0006464)	1.79	9	ATXN3, TGM6, SCYL1, SPTBN2, FGF14, TTBK2, ATXN7, EEF2, PRKCG
nitrogen compound metabolic process (GO:0006807)	1.13	9	CACNA1A, ATXN1, ATXN2, TBP, ATXN3, SCYL1, NOP56, EEF2, ATXN7
signal transduction (GO:0007165)	1.28	9	CACNA1A, CCDC88C, FGF14, SPTBN2, TRPC3, PDYN, TTBK2, ITPR1, PRKCG
protein modification process (GO:0036211)	1.79	9	ATXN3, TGM6, SCYL1, SPTBN2, FGF14, TTBK2, ATXN7, EEF2, PRKCG
regulation of localization (GO:0032879)	1.94	9	CACNA1A, TRPC3, ATXN2, FGF14, KCNC3, CACNA1G, KCND3, ITPR1, PRKCG
developmental process (GO:0032502)	1.36	8	CACNA1A, FGF14, AFG3L2, SPTBN2, EEF2, ATXN10, ATXN3, TTBK2
organic substance biosynthetic process (GO:1901576)	1.34	8	ATXN1, TBP, ATXN3, SCYL1, ELOVL5, ELOVL4, EEF2, ATXN7
macromolecular complex subunit organization (GO:0043933)	2.14	8	CCDC88C, ATXN2, ATXN3, AFG3L2, KCNC3, KCND3, ATXN10, ATXN7
regulation of biosynthetic process (GO:0009889)	1.37	8	CACNA1A, ATXN1, ATXN2, TBP, ATXN3, SCYL1, EEF2, ATXN7
regulation of response to stimulus (GO:0048583)	1.54	8	FGF14, TBP, ATXN7, TRPC3, ATXN3, PLEKHG4, ITPR1, PRKCG
cellular nitrogen compound metabolic process (GO:0034641)	1.22	8	ATXN1, ATXN2, TBP, ATXN3, SCYL1, NOP56, EEF2, ATXN7
cellular biosynthetic process (GO:0044249)	1.37	8	ATXN1, TBP, ATXN3, SCYL1, ELOVL5, ELOVL4, EEF2, ATXN7
biosynthetic process (GO:0009058)	1.32	8	ATXN1, TBP, ATXN3, SCYL1, ELOVL5, ELOVL4, EEF2, ATXN7
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	8	ATXN1, ATXN2, TBP, ATXN3, SCYL1, EEF2, ATXN7, PRKCG
regulation of cellular biosynthetic process (GO:0031326)	1.38	8	CACNA1A, ATXN1, ATXN2, TBP, ATXN3, SCYL1, EEF2, ATXN7
positive regulation of biological process (GO:0048518)	1.2	8	TRPC3, TBP, ATXN3, CACNA1G, FGF14, EEF2, ATXN7, PRKCG
RNA metabolic process (GO:0016070)	1.59	7	ATXN1, ATXN2, TBP, ATXN3, SCYL1, NOP56, ATXN7
single organism signaling (GO:0044700)	3.25	7	CACNA1A, FGF14, CACNA1G, KCND3, PDYN, ATXN3, PRKCG
cellular response to stimulus (GO:0051716)	1.97	7	CCDC88C, ATXN3, SPTBN2, KCND3, FGF14, EEF2, ITPR1
nucleobase-containing compound metabolic process (GO:0006139)	1.35	7	ATXN1, ATXN2, TBP, ATXN3, SCYL1, NOP56, ATXN7
cellular aromatic compound metabolic process (GO:0006725)	1.3	7	ATXN1, ATXN2, TBP, ATXN3, SCYL1, NOP56, ATXN7
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	7	ATXN1, ATXN2, TBP, ATXN3, SCYL1, EEF2, ATXN7
regulation of gene expression (GO:0010468)	1.37	7	ATXN1, ATXN2, TBP, ATXN3, SCYL1, EEF2, ATXN7
nucleic acid metabolic process (GO:0090304)	1.46	7	ATXN1, ATXN2, TBP, ATXN3, SCYL1, NOP56, ATXN7
response to stress (GO:0006950)	1.8	7	CACNA1A, CCDC88C, ITPR1, FGF14, EEF2, ATXN3, PRKCG
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	7	ATXN1, ATXN2, TBP, ATXN3, SCYL1, EEF2, ATXN7
signaling (GO:0023052)	3.25	7	CACNA1A, FGF14, CACNA1G, KCND3, PDYN, ATXN3, PRKCG
negative regulation of cellular process (GO:0048523)	1.41	7	CACNA1A, ATXN2, ATXN7, ATXN1, SPTBN2, ITPR1, PRKCG
negative regulation of biological process (GO:0048519)	1.33	7	CACNA1A, ATXN2, ATXN7, ATXN1, SPTBN2, ITPR1, PRKCG
response to chemical (GO:0042221)	1.98	7	TRPC3, SPTBN2, CACNA1G, KCND3, EEF2, ATXN3, PRKCG
positive regulation of cellular process (GO:0048522)	1.3	7	TRPC3, TBP, ATXN3, CACNA1G, EEF2, ATXN7, PRKCG
transmembrane transport (GO:0055085)	2.72	7	CACNA1A, TRPC3, AFG3L2, KCNC3, CACNA1G, KCND3, ITPR1
organic cyclic compound metabolic process (GO:1901360)	1.26	7	ATXN1, ATXN2, TBP, ATXN3, SCYL1, NOP56, ATXN7
heterocycle metabolic process (GO:0046483)	1.31	7	ATXN1, ATXN2, TBP, ATXN3, SCYL1, NOP56, ATXN7
cellular macromolecule biosynthetic process (GO:0034645)	1.66	6	ATXN1, TBP, ATXN3, SCYL1, EEF2, ATXN7
regulation of signaling (GO:0023051)	1.72	6	CACNA1A, FGF14, TBP, ATXN7, PLEKHG4, ITPR1
regulation of cell communication (GO:0010646)	1.73	6	CACNA1A, FGF14, TBP, ATXN7, PLEKHG4, ITPR1
regulation of ion transport (GO:0043269)	3.4	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, FGF14
regulation of protein metabolic process (GO:0051246)	1.93	6	CCDC88C, ATXN2, PPP2R2B, EEF2, ATXN3, PRKCG
macromolecular complex assembly (GO:0065003)	2.55	6	CCDC88C, ATXN2, AFG3L2, KCNC3, KCND3, ATXN10
inorganic cation transmembrane transport (GO:0098662)	3.55	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
inorganic ion transmembrane transport (GO:0098660)	3.38	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	6	ATXN1, TBP, ATXN3, SCYL1, ATXN7, PRKCG
cation transport (GO:0006812)	3.11	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
ion transport (GO:0006811)	2.66	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
single-organism developmental process (GO:0044767)	1.49	6	CACNA1A, AFG3L2, SPTBN2, TTBK2, EEF2, ATXN10
ion transmembrane transport (GO:0034220)	3.08	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
macromolecule biosynthetic process (GO:0009059)	1.61	6	ATXN1, TBP, ATXN3, SCYL1, EEF2, ATXN7
metal ion transport (GO:0030001)	3.36	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
regulation of multicellular organismal process (GO:0051239)	1.87	6	CACNA1A, TRPC3, AFG3L2, CACNA1G, KCND3, ITPR1
cell-cell signaling (GO:0007267)	3.35	6	CACNA1A, ATXN3, CACNA1G, PDYN, FGF14, PRKCG
cell communication (GO:0007154)	3.04	6	CACNA1A, ATXN3, CACNA1G, PDYN, FGF14, PRKCG
response to organic substance (GO:0010033)	2.2	6	SPTBN2, TRPC3, KCND3, EEF2, ATXN3, PRKCG
organelle organization (GO:0006996)	2.02	6	ATXN2, ATXN7, AFG3L2, TTBK2, ATXN3, ATXN10
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	6	ATXN1, TBP, ATXN3, SCYL1, EEF2, ATXN7
single-multicellular organism process (GO:0044707)	1.78	6	CACNA1A, SPTBN2, CACNA1G, KCND3, ITPR1, PRKCG
cation transmembrane transport (GO:0098655)	3.43	6	CACNA1A, TRPC3, KCNC3, CACNA1G, KCND3, ITPR1
regulation of RNA metabolic process (GO:0051252)	1.52	5	SCYL1, ATXN7, TBP, ATXN3, ATXN1
negative regulation of metabolic process (GO:0009892)	1.93	5	CACNA1A, ATXN1, ATXN7, PRKCG, ATXN2
positive regulation of metabolic process (GO:0009893)	1.74	5	TBP, ATXN7, EEF2, ATXN3, PRKCG
phosphorylation (GO:0016310)	2.63	5	FGF14, TTBK2, SCYL1, PRKCG, SPTBN2
chemical synaptic transmission (GO:0007268)	3.98	5	CACNA1A, CACNA1G, ATXN3, PRKCG, PDYN
regulation of cellular component organization (GO:0051128)	2.01	5	CACNA1A, TTBK2, PRKCG, SPTBN2, ATXN2
regulation of ion transmembrane transport (GO:0034765)	3.77	5	CACNA1A, CACNA1G, KCND3, KCNC3, FGF14
intracellular signal transduction (GO:0035556)	2.39	5	CCDC88C, FGF14, ITPR1, PRKCG, SPTBN2
organic cyclic compound biosynthetic process (GO:1901362)	1.66	5	TBP, ATXN1, ATXN7, ATXN3, SCYL1
nucleic acid-templated transcription (GO:0097659)	1.91	5	TBP, SCYL1, ATXN3, ATXN7, ATXN1
RNA biosynthetic process (GO:0032774)	1.84	5	TBP, ATXN7, ATXN3, SCYL1, ATXN1
single-organism metabolic process (GO:0044710)	1.63	5	CACNA1A, ELOVL4, FGF14, ELOVL5, SPTBN2
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	5	TBP, ATXN7, EEF2, ATXN3, PRKCG
establishment of localization in cell (GO:0051649)	2.47	5	CACNA1A, ATXN1, AFG3L2, ITPR1, SPTBN2
single-organism organelle organization (GO:1902589)	2.68	5	AFG3L2, ATXN10, ATXN3, TTBK2, ATXN7
regulation of transmembrane transport (GO:0034762)	3.74	5	CACNA1A, CACNA1G, KCND3, FGF14, KCNC3
heterocycle biosynthetic process (GO:0018130)	1.7	5	TBP, SCYL1, ATXN7, ATXN3, ATXN1
protein phosphorylation (GO:0006468)	2.89	5	FGF14, TTBK2, SCYL1, PRKCG, SPTBN2
negative regulation of cellular metabolic process (GO:0031324)	2.01	5	CACNA1A, ATXN1, ATXN7, PRKCG, ATXN2
protein complex assembly (GO:0006461)	2.78	5	CCDC88C, AFG3L2, ATXN10, KCNC3, KCND3
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	5	ATXN1, ATXN7, TBP, ATXN3, SCYL1
regulation of vesicle-mediated transport (GO:0060627)	3.63	5	CACNA1A, CACNA1G, FGF14, PRKCG, ATXN2
single-organism transport (GO:0044765)	2.18	5	CACNA1A, KCNC3, KCND3, ITPR1, AFG3L2
regulation of RNA biosynthetic process (GO:2001141)	1.55	5	ATXN1, ATXN7, TBP, ATXN3, SCYL1
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	5	TBP, ATXN1, ATXN7, ATXN3, SCYL1
single-organism localization (GO:1902578)	2.09	5	CACNA1A, KCNC3, KCND3, ITPR1, AFG3L2
system process (GO:0003008)	2.3	5	CACNA1A, EEF2, ATXN7, PRKCG, PDYN
regulation of cellular protein metabolic process (GO:0032268)	1.99	5	CCDC88C, PPP2R2B, EEF2, PRKCG, ATXN2
protein complex subunit organization (GO:0071822)	2.6	5	CCDC88C, KCND3, AFG3L2, KCNC3, ATXN10
response to external stimulus (GO:0009605)	2.55	5	CACNA1A, TRPC3, ELOVL4, AFG3L2, EEF2
anatomical structure development (GO:0048856)	1.58	5	CACNA1A, FGF14, ATXN10, ATXN3, AFG3L2
regulation of transcription, DNA-templated (GO:0006355)	1.56	5	TBP, ATXN7, ATXN3, SCYL1, ATXN1
phosphate-containing compound metabolic process (GO:0006796)	2.16	5	FGF14, TTBK2, SCYL1, PRKCG, SPTBN2
anterograde trans-synaptic signaling (GO:0098916)	3.98	5	CACNA1A, CACNA1G, ATXN3, PRKCG, PDYN
transcription, DNA-templated (GO:0006351)	1.91	5	TBP, ATXN1, ATXN3, ATXN7, SCYL1
cellular response to stress (GO:0033554)	2.51	5	CCDC88C, ATXN3, EEF2, ITPR1, FGF14
phosphorus metabolic process (GO:0006793)	2.15	5	SCYL1, TTBK2, FGF14, PRKCG, SPTBN2
aromatic compound biosynthetic process (GO:0019438)	1.7	5	TBP, ATXN1, ATXN3, ATXN7, SCYL1
synaptic signaling (GO:0099536)	3.98	5	CACNA1A, CACNA1G, ATXN3, PRKCG, PDYN
trans-synaptic signaling (GO:0099537)	3.98	5	CACNA1A, CACNA1G, ATXN3, PDYN, PRKCG
regulation of membrane potential (GO:0042391)	3.89	4	CACNA1A, CACNA1G, KCND3, FGF14
cell projection organization (GO:0030030)	3.14	4	CACNA1A, ATXN10, AFG3L2, TTBK2
positive regulation of cellular metabolic process (GO:0031325)	1.81	4	TBP, EEF2, ATXN7, PRKCG
behavior (GO:0007610)	3.47	4	CACNA1A, ATXN3, PRKCG, SPTBN2
cellular response to chemical stimulus (GO:0070887)	2.57	4	KCND3, ATXN3, EEF2, SPTBN2
response to endogenous stimulus (GO:0009719)	2.79	4	TRPC3, KCND3, EEF2, PRKCG
regulation of system process (GO:0044057)	3.53	4	TRPC3, CACNA1G, KCND3, ITPR1
regulation of signal transduction (GO:0009966)	1.84	4	TBP, ITPR1, ATXN7, PLEKHG4
protein homooligomerization (GO:0051260)	4.21	4	CCDC88C, ATXN10, KCNC3, KCND3
peptidyl-amino acid modification (GO:0018193)	2.98	4	TTBK2, SCYL1, EEF2, PRKCG
cellular response to organic substance (GO:0071310)	2.78	4	KCND3, ATXN3, EEF2, SPTBN2
regulation of molecular function (GO:0065009)	1.78	4	PPP2R2B, FGF14, PLEKHG4, SPTBN2
neurological system process (GO:0050877)	2.64	4	CACNA1A, ATXN7, PRKCG, PDYN
calcium ion transport (GO:0006816)	4.33	4	CACNA1A, CACNA1G, ITPR1, TRPC3
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	4	TBP, EEF2, ATXN7, PRKCG
divalent inorganic cation transport (GO:0072511)	4.13	4	CACNA1A, CACNA1G, ITPR1, TRPC3
cellular localization (GO:0051641)	2.32	4	CACNA1A, AFG3L2, ATXN1, SPTBN2
protein oligomerization (GO:0051259)	3.71	4	CCDC88C, ATXN10, KCNC3, KCND3
response to abiotic stimulus (GO:0009628)	2.8	4	TRPC3, ATXN3, ELOVL4, ITPR1
divalent metal ion transport (GO:0070838)	4.15	4	TRPC3, CACNA1A, CACNA1G, ITPR1
single-organism behavior (GO:0044708)	3.79	4	CACNA1A, ATXN3, SPTBN2, PRKCG
regulation of response to stress (GO:0080134)	2.53	4	TRPC3, FGF14, ATXN3, PRKCG
calcium ion transmembrane transport (GO:0070588)	4.67	4	CACNA1A, CACNA1G, ITPR1, TRPC3
protein localization (GO:0008104)	2.36	3	CACNA1A, AFG3L2, ATXN3
regulation of phosphate metabolic process (GO:0019220)	2.35	3	CCDC88C, PPP2R2B, ATXN7
regulation of cellular localization (GO:0060341)	3.03	3	CACNA1A, TRPC3, FGF14
positive regulation of biosynthetic process (GO:0009891)	2.29	3	TBP, EEF2, ATXN7
positive regulation of response to stimulus (GO:0048584)	2.18	3	TRPC3, ATXN3, PRKCG
regulation of homeostatic process (GO:0032844)	3.65	3	TRPC3, CACNA1G, ITPR1
synapse organization (GO:0050808)	4.87	3	CACNA1A, AFG3L2, SPTBN2
positive regulation of gene expression (GO:0010628)	2.35	3	TBP, EEF2, ATXN7
small molecule metabolic process (GO:0044281)	2.38	3	CACNA1A, ELOVL4, ELOVL5
cell surface receptor signaling pathway (GO:0007166)	2.09	3	CCDC88C, TTBK2, FGF14
cell death (GO:0008219)	3.05	3	CACNA1A, PPP2R2B, ITPR1
anatomical structure morphogenesis (GO:0009653)	2.53	3	CACNA1A, AFG3L2, SPTBN2
multicellular organismal signaling (GO:0035637)	5.36	3	CACNA1A, CACNA1G, KCND3
response to organic cyclic compound (GO:0014070)	3.07	3	TRPC3, EEF2, PRKCG
regulation of intracellular signal transduction (GO:1902531)	2.31	3	TBP, ITPR1, PLEKHG4
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	3	ATXN1, PRKCG, ATXN2
regulation of secretion (GO:0051046)	3.2	3	CACNA1A, CACNA1G, ITPR1
cellular developmental process (GO:0048869)	1.82	3	CACNA1A, AFG3L2, EEF2
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	3	TBP, EEF2, ATXN7
platelet activation (GO:0030168)	4.96	3	TRPC3, ITPR1, PRKCG
positive regulation of molecular function (GO:0044093)	2.23	3	FGF14, PLEKHG4, SPTBN2
regulation of protein modification process (GO:0031399)	2.32	3	CCDC88C, PPP2R2B, PRKCG
proteolysis (GO:0006508)	2.73	3	ATXN3, AFG3L2, ATXN7
macromolecule localization (GO:0033036)	2.34	3	CACNA1A, AFG3L2, ATXN3
regulation of hydrolase activity (GO:0051336)	2.53	3	PPP2R2B, PLEKHG4, SPTBN2
regulation of heart contraction (GO:0008016)	4.35	3	CACNA1G, KCND3, ITPR1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	3	TBP, ATXN7, PRKCG
positive regulation of transport (GO:0051050)	2.9	3	TRPC3, CACNA1G, FGF14
regulation of developmental process (GO:0050793)	2.1	3	CACNA1A, TTBK2, AFG3L2
regulation of catalytic activity (GO:0050790)	1.97	3	PPP2R2B, PLEKHG4, SPTBN2
regulation of phosphorus metabolic process (GO:0051174)	2.35	3	CCDC88C, PPP2R2B, ATXN7
cell activation (GO:0001775)	3.47	3	TRPC3, ITPR1, PRKCG
regulation of blood circulation (GO:1903522)	4.05	3	CACNA1G, KCND3, ITPR1
organic substance transport (GO:0071702)	2.15	3	CACNA1A, AFG3L2, ATXN2
response to inorganic substance (GO:0010035)	3.56	3	TRPC3, CACNA1G, EEF2
organelle assembly (GO:0070925)	3.75	3	TTBK2, ATXN10, ATXN2
response to oxygen-containing compound (GO:1901700)	2.57	3	TRPC3, EEF2, SPTBN2
organic acid metabolic process (GO:0006082)	3.01	3	CACNA1A, ELOVL4, ELOVL5
vesicle-mediated transport (GO:0016192)	2.72	3	CACNA1A, SCYL1, SPTBN2
intracellular transport (GO:0046907)	2.67	3	AFG3L2, ATXN1, SPTBN2
response to organonitrogen compound (GO:0010243)	3.2	3	TRPC3, EEF2, PRKCG
nervous system development (GO:0007399)	3.53	3	FGF14, ATXN10, ATXN3
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	3	TBP, EEF2, ATXN7
regulation of ion homeostasis (GO:2000021)	4.44	3	TRPC3, CACNA1G, ITPR1
system development (GO:0048731)	2.92	3	FGF14, ATXN10, ATXN3
response to nitrogen compound (GO:1901698)	3.12	3	TRPC3, EEF2, PRKCG
regulation of secretion by cell (GO:1903530)	3.28	3	CACNA1A, CACNA1G, ITPR1
regulation of peptide transport (GO:0090087)	4.37	2	CACNA1A, ITPR1
reflex (GO:0060004)	6.68	2	CACNA1A, AFG3L2
negative regulation of response to stimulus (GO:0048585)	2.52	2	ITPR1, ATXN7
membrane organization (GO:0061024)	3.04	2	CACNA1A, AFG3L2
membrane depolarization (GO:0051899)	5.62	2	CACNA1A, CACNA1G
regulation of neuron apoptotic process (GO:0043523)	4.47	2	CACNA1A, PRKCG
negative regulation of neuron apoptotic process (GO:0043524)	4.82	2	CACNA1A, PRKCG
calcium ion homeostasis (GO:0055074)	3.97	2	CACNA1A, ITPR1
small molecule biosynthetic process (GO:0044283)	3.79	2	ELOVL4, ELOVL5
inorganic ion homeostasis (GO:0098771)	3.43	2	CACNA1A, ITPR1
very long-chain fatty acid biosynthetic process (GO:0042761)	7.33	2	ELOVL4, ELOVL5
cellular chemical homeostasis (GO:0055082)	3.4	2	CACNA1A, ITPR1
signal transduction by protein phosphorylation (GO:0023014)	3.79	2	FGF14, SPTBN2
response to pain (GO:0048265)	6.78	2	CACNA1A, PRKCG
single-organism biosynthetic process (GO:0044711)	2.8	2	ELOVL4, ELOVL5
negative regulation of signal transduction (GO:0009968)	2.75	2	ITPR1, ATXN7
cellular macromolecule localization (GO:0070727)	3.1	2	CACNA1A, AFG3L2
posttranscriptional regulation of gene expression (GO:0010608)	3.64	2	EEF2, ATXN2
regulation of response to external stimulus (GO:0032101)	3.06	2	FGF14, PRKCG
MAPK cascade (GO:0000165)	3.91	2	FGF14, SPTBN2
response to growth factor (GO:0070848)	4.14	2	KCND3, EEF2
cellular homeostasis (GO:0019725)	3.23	2	CACNA1A, ITPR1
negative regulation of cell death (GO:0060548)	2.95	2	CACNA1A, PRKCG
sensory perception (GO:0007600)	2.93	2	ATXN7, PDYN
monocarboxylic acid metabolic process (GO:0032787)	3.57	2	ELOVL4, ELOVL5
regulation of peptide hormone secretion (GO:0090276)	4.41	2	CACNA1A, ITPR1
response to metal ion (GO:0010038)	3.91	2	TRPC3, CACNA1G
oxoacid metabolic process (GO:0043436)	3.12	2	ELOVL4, ELOVL5
organonitrogen compound metabolic process (GO:1901564)	2.32	2	CACNA1A, EEF2
cellular component assembly involved in morphogenesis (GO:0010927)	4.29	2	TTBK2, ATXN10
protein modification by small protein conjugation or removal (GO:0070647)	2.95	2	ATXN3, ATXN7
regulation of phosphorylation (GO:0042325)	2.5	2	CCDC88C, ATXN7
single organism reproductive process (GO:0044702)	2.73	2	TRPC3, TBP
peptidyl-serine modification (GO:0018209)	4.72	2	TTBK2, PRKCG
protein deubiquitination (GO:0016579)	4.97	2	ATXN3, ATXN7
organic acid biosynthetic process (GO:0016053)	4.26	2	ELOVL4, ELOVL5
chemical homeostasis (GO:0048878)	2.97	2	CACNA1A, ITPR1
calcium ion import (GO:0070509)	5.57	2	CACNA1G, ITPR1
multicellular organismal response to stress (GO:0033555)	5.67	2	CACNA1A, PRKCG
cilium organization (GO:0044782)	4.67	2	ATXN10, TTBK2
protein modification by small protein removal (GO:0070646)	4.83	2	ATXN3, ATXN7
covalent chromatin modification (GO:0016569)	3.89	2	ATXN3, ATXN7
regulation of cell morphogenesis (GO:0022604)	3.4	2	CACNA1A, TTBK2
regulation of catabolic process (GO:0009894)	3.52	2	ATXN3, PRKCG
negative regulation of biosynthetic process (GO:0009890)	2.47	2	CACNA1A, ATXN1
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	CACNA1A, TTBK2
fatty acid elongation (GO:0030497)	7.24	2	ELOVL4, ELOVL5
cilium assembly (GO:0042384)	4.77	2	TTBK2, ATXN10
microtubule cytoskeleton organization (GO:0000226)	4.13	2	ATXN3, ATXN7
ncRNA metabolic process (GO:0034660)	3.44	2	TBP, NOP56
regulation of protein transport (GO:0051223)	3.12	2	CACNA1A, ITPR1
regulation of apoptotic process (GO:0042981)	2.5	2	CACNA1A, PRKCG
monocarboxylic acid biosynthetic process (GO:0072330)	4.74	2	ELOVL4, ELOVL5
regulation of protein secretion (GO:0050708)	3.77	2	CACNA1A, ITPR1
positive regulation of GTPase activity (GO:0043547)	3.28	2	PLEKHG4, SPTBN2
positive regulation of hydrolase activity (GO:0051345)	2.91	2	PLEKHG4, SPTBN2
histone modification (GO:0016570)	3.91	2	ATXN3, ATXN7
regulation of regulated secretory pathway (GO:1903305)	4.98	2	CACNA1A, CACNA1G
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	2	CACNA1A, PDYN
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	2	TTBK2, ATXN10
regulation of establishment of protein localization (GO:0070201)	3.02	2	CACNA1A, ITPR1
cellular protein localization (GO:0034613)	3.11	2	CACNA1A, AFG3L2
lipid metabolic process (GO:0006629)	2.68	2	ELOVL4, ELOVL5
potassium ion transport (GO:0006813)	4.68	2	KCND3, KCNC3
regulation of insulin secretion (GO:0050796)	4.57	2	CACNA1A, ITPR1
programmed cell death (GO:0012501)	3.1	2	PPP2R2B, ITPR1
single-organism membrane organization (GO:0044802)	3.19	2	CACNA1A, AFG3L2
very long-chain fatty acid metabolic process (GO:0000038)	6.33	2	ELOVL4, ELOVL5
regulation of neuron death (GO:1901214)	4.19	2	CACNA1A, PRKCG
negative regulation of neuron death (GO:1901215)	4.57	2	CACNA1A, PRKCG
detection of stimulus (GO:0051606)	3.22	2	TRPC3, ELOVL4
reproductive process (GO:0022414)	2.55	2	TBP, TRPC3
carboxylic acid biosynthetic process (GO:0046394)	4.32	2	ELOVL4, ELOVL5
regulation of cellular response to stress (GO:0080135)	3.4	2	ATXN3, PRKCG
neuron projection morphogenesis (GO:0048812)	4.34	2	CACNA1A, AFG3L2
response to alcohol (GO:0097305)	4.58	2	EEF2, SPTBN2
positive regulation of cytosolic calcium ion concentration (GO:0007204)	4.56	2	CACNA1A, ITPR1
fatty acid biosynthetic process (GO:0006633)	5.01	2	ELOVL4, ELOVL5
fatty acid metabolic process (GO:0006631)	4.03	2	ELOVL4, ELOVL5
positive regulation of catalytic activity (GO:0043085)	2.4	2	PLEKHG4, SPTBN2
regulation of organelle organization (GO:0033043)	2.72	2	SPTBN2, ATXN2
response to radiation (GO:0009314)	3.69	2	TRPC3, ELOVL4
ion homeostasis (GO:0050801)	3.42	2	CACNA1A, ITPR1
cell differentiation (GO:0030154)	2.14	2	CACNA1A, EEF2
negative regulation of cellular component organization (GO:0051129)	3.35	2	SPTBN2, ATXN2
stress-activated protein kinase signaling cascade (GO:0031098)	5.41	2	CCDC88C, FGF14
negative regulation of signaling (GO:0023057)	2.65	2	ITPR1, ATXN7
regulation of protein catabolic process (GO:0042176)	3.83	2	ATXN3, PRKCG
response to light stimulus (GO:0009416)	4.08	2	TRPC3, ELOVL4
negative regulation of cell communication (GO:0010648)	2.66	2	ITPR1, ATXN7
regulation of GTPase activity (GO:0043087)	3.21	2	PLEKHG4, SPTBN2
synapse assembly (GO:0007416)	5.55	2	CACNA1A, SPTBN2
regulation of protein localization (GO:0032880)	2.88	2	CACNA1A, ITPR1
divalent inorganic cation homeostasis (GO:0072507)	3.9	2	CACNA1A, ITPR1
musculoskeletal movement (GO:0050881)	7.24	2	CACNA1A, ITPR1
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	2	CACNA1A, ITPR1
cellular potassium ion transport (GO:0071804)	4.79	2	KCND3, KCNC3
potassium ion transmembrane transport (GO:0071805)	4.79	2	KCND3, KCNC3
positive regulation of protein metabolic process (GO:0051247)	2.43	2	EEF2, ATXN3
regulation of calcium ion-dependent exocytosis (GO:0017158)	5.47	2	CACNA1A, CACNA1G
monovalent inorganic cation transport (GO:0015672)	3.74	2	KCND3, KCNC3
regulation of exocytosis (GO:0017157)	4.59	2	CACNA1A, CACNA1G
cellular response to endogenous stimulus (GO:0071495)	3.33	2	KCND3, EEF2
multicellular organismal movement (GO:0050879)	7.24	2	CACNA1A, ITPR1
cellular metal ion homeostasis (GO:0006875)	3.75	2	CACNA1A, ITPR1
cellular calcium ion homeostasis (GO:0006874)	4.01	2	CACNA1A, ITPR1
cellular ion homeostasis (GO:0006873)	3.57	2	CACNA1A, ITPR1
regulation of cellular amide metabolic process (GO:0034248)	3.88	2	EEF2, ATXN2
positive regulation of ion transport (GO:0043270)	4.36	2	TRPC3, FGF14
regulation of hormone secretion (GO:0046883)	4.18	2	CACNA1A, ITPR1
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	2	TBP, ATXN7
cellular cation homeostasis (GO:0030003)	3.6	2	CACNA1A, ITPR1
cation homeostasis (GO:0055080)	3.46	2	CACNA1A, ITPR1
cellular lipid metabolic process (GO:0044255)	2.92	2	ELOVL4, ELOVL5
membrane depolarization during action potential (GO:0086010)	6.07	2	CACNA1A, CACNA1G
modulation of synaptic transmission (GO:0050804)	4.09	2	CACNA1A, FGF14
cell part morphogenesis (GO:0032990)	3.99	2	CACNA1A, AFG3L2
cellular response to growth factor stimulus (GO:0071363)	4.27	2	KCND3, EEF2
positive regulation of RNA metabolic process (GO:0051254)	2.51	2	TBP, ATXN7
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	2	TBP, ATXN7
response to endoplasmic reticulum stress (GO:0034976)	4.46	2	EEF2, ITPR1
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	2	TBP, ATXN7
peptidyl-serine phosphorylation (GO:0018105)	4.82	2	TTBK2, PRKCG
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	2	CACNA1A, ATXN1
cell projection assembly (GO:0030031)	4.19	2	ATXN10, TTBK2
carboxylic acid metabolic process (GO:0019752)	3.12	2	ELOVL4, ELOVL5
homeostatic process (GO:0042592)	2.61	2	CACNA1A, ITPR1
regulation of cell death (GO:0010941)	2.43	2	CACNA1A, PRKCG
growth (GO:0040007)	3.8	2	CACNA1A, SPTBN2
chromatin organization (GO:0006325)	3.28	2	ATXN3, ATXN7
cellular component morphogenesis (GO:0032989)	3.5	2	CACNA1A, AFG3L2
nitrogen compound transport (GO:0071705)	3.54	2	CACNA1A, ATXN2
regulation of programmed cell death (GO:0043067)	2.49	2	CACNA1A, PRKCG
negative regulation of apoptotic process (GO:0043066)	3.04	2	CACNA1A, PRKCG
negative regulation of programmed cell death (GO:0043069)	3.02	2	CACNA1A, PRKCG
detection of external stimulus (GO:0009581)	4.98	2	TRPC3, ELOVL4
detection of abiotic stimulus (GO:0009582)	4.96	2	TRPC3, ELOVL4
detection of light stimulus (GO:0009583)	5.67	2	TRPC3, ELOVL4
cardiac conduction (GO:0061337)	5.54	2	CACNA1G, KCND3
Golgi vesicle transport (GO:0048193)	4.07	2	SCYL1, SPTBN2
apoptotic process (GO:0006915)	3.14	2	PPP2R2B, ITPR1
regulation of hormone levels (GO:0010817)	3.56	2	CACNA1A, ITPR1
regulation of metal ion transport (GO:0010959)	3.94	2	TRPC3, FGF14
response to ethanol (GO:0045471)	4.83	2	EEF2, SPTBN2
metal ion homeostasis (GO:0055065)	3.61	2	CACNA1A, ITPR1
regulation of endocytosis (GO:0030100)	4.42	2	PRKCG, ATXN2
lipid biosynthetic process (GO:0008610)	3.49	2	ELOVL4, ELOVL5
adult behavior (GO:0030534)	4.79	2	CACNA1A, SPTBN2
microtubule-based process (GO:0007017)	3.54	2	ATXN3, ATXN7
cytoskeleton organization (GO:0007010)	3.22	2	ATXN3, ATXN7
cell projection morphogenesis (GO:0048858)	4.05	2	CACNA1A, AFG3L2
positive regulation of calcium ion transport (GO:0051928)	5.06	2	TRPC3, FGF14
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	2	CACNA1A, ITPR1
regulation of peptide secretion (GO:0002791)	4.38	2	CACNA1A, ITPR1
regulation of calcium ion transport (GO:0051924)	4.38	2	TRPC3, FGF14
regulation of cellular component biogenesis (GO:0044087)	3.08	2	SPTBN2, ATXN2
sulfur compound metabolic process (GO:0006790)	3.87	2	CACNA1A, ELOVL5
regulation of translation (GO:0006417)	3.96	2	EEF2, ATXN2
single-organism cellular localization (GO:1902580)	3.16	2	CACNA1A, AFG3L2
RNA processing (GO:0006396)	3.01	2	ATXN1, NOP56

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
single organism signaling (GO:0044700)	-	3.25	0.02	CACNA1A, TRPC3, ITPR1, FGF14, TBP, ATXN1, KCNC3, SPTBN2, CACNA1G, KCND3, PDYN, ATXN3, PRKCG
cell development (GO:0048468)	NEW	3.28	0.008	CACNA1A, TRPC3, ATXN2, TBP, ITPR1, AFG3L2, ATXN1, SPTBN2, CACNA1G, NOP56, EEF2, ATXN3, PRKCG
regulation of metal ion transport (GO:0010959)	-	3.94	0.033	CACNA1A, TRPC3, TBP, ITPR1, ATXN1, CACNA1G, FGF14, PRKCG
single-organism cellular process (GO:0044763)	-	0.65	0.014	PDYN, TBP, ATXN1, BEAN1, ELOVL4, ATXN10, FGF14, EEF2, PRKCG, ATXN3, TGM6, KCND3, CACNA1A, ATXN8, SPTBN2, PPP2R2B, SCA7, TTBK2, ITPR1, TRPC3, ATXN2, AFG3L2, KCNC3, CACNA1G, ELOVL5, NOP56
cell communication (GO:0007154)	-	3.04	0.032	CACNA1A, FGF14, KCNC3, CACNA1G, KCND3, PDYN, ATXN3, PRKCG
signaling (GO:0023052)	-	3.25	0.02	CACNA1A, TRPC3, ATXN1, TBP, FGF14, KCNC3, SPTBN2, CACNA1G, KCND3, ATXN3, PDYN, ITPR1, PRKCG
regulation of transmembrane transport (GO:0034762)	-	3.74	0.014	CACNA1A, TRPC3, TBP, ATXN1, KCNC3, CACNA1G, KCND3, ITPR1, PRKCG
synaptic transmission (GO:0007268)	-	3.98	0.0	CACNA1A, TRPC3, ATXN1, TBP, FGF14, KCNC3, SPTBN2, CACNA1G, KCND3, ATXN3, PDYN, ITPR1, PRKCG
cell-cell signaling (GO:0007267)	-	3.35	0.008	CACNA1A, TRPC3, ATXN1, TBP, ITPR1, KCNC3, SPTBN2, CACNA1G, KCND3, ATXN3, PDYN, FGF14, PRKCG
regulation of ion transmembrane transport (GO:0034765)	-	3.77	0.008	CACNA1A, TRPC3, TBP, ATXN1, KCNC3, CACNA1G, KCND3, ITPR1, PRKCG
cell death (GO:0008219)	-	3.05	0.0	PDYN, TBP, ATXN1, BEAN1, EEF2, FGF14, ATXN10, PRKCG, ATXN3, TGM6, CACNA1A, ATXN8, SPTBN2, PPP2R2B, SCA7, TTBK2, ITPR1, TRPC3, ATXN2, AFG3L2, KCNC3, KCND3, NOP56
very long-chain fatty acid biosynthetic process (GO:0042761)	-	7.33	0.04	ELOVL4, ELOVL5
regulation of ion transport (GO:0043269)	-	3.4	0.011	CACNA1A, TRPC3, ATXN1, TBP, FGF14, KCNC3, SPTBN2, CACNA1G, KCND3, ITPR1, PRKCG

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	29	CCDC88C, ATXN1, TBP, SCYL1, ELOVL4, ATXN10, FGF14, EEF2, PRKCG, ATXN7, TGM6, ELOVL5, TMEM240, ATXN8OS, CACNA1A, ATXN8, SPTBN2, TRPC3, PDYN, TTBK2, ITPR1, PPP2R2B, ATXN2, AFG3L2, KCNC3, CACNA1G, KCND3, ATXN3, NOP56
intracellular part (GO:0044424)	0.28	25	CCDC88C, TBP, ATXN1, ELOVL4, ATXN10, FGF14, EEF2, PRKCG, ATXN7, TGM6, KCND3, ATXN8OS, CACNA1A, ATXN8, SPTBN2, PPP2R2B, PDYN, TTBK2, ITPR1, ATXN2, AFG3L2, SCYL1, ELOVL5, ATXN3, NOP56
membrane (GO:0016020)	0.68	21	CACNA1A, TRPC3, BEAN1, ATXN2, ELOVL5, ATXN3, AFG3L2, KCNC3, TMEM240, SPTBN2, PPP2R2B, CACNA1G, KCND3, NOP56, EEF2, PDYN, SCYL1, ATXN10, ITPR1, ELOVL4, PRKCG
cytoplasm (GO:0005737)	1.01	19	CCDC88C, CACNA1A, ATXN1, ATXN2, TBP, ATXN3, TGM6, ATXN10, SCYL1, SPTBN2, PPP2R2B, ATXN7, NOP56, EEF2, PDYN, TTBK2, ITPR1, ATXN8OS, PRKCG
intracellular organelle (GO:0043229)	0.51	19	CACNA1A, ATXN1, ATXN2, TBP, FGF14, AFG3L2, SCYL1, ELOVL5, SPTBN2, PPP2R2B, ELOVL4, ATXN3, NOP56, EEF2, ATXN7, TTBK2, ITPR1, ATXN8, PRKCG
membrane-bounded organelle (GO:0043227)	0.47	19	CACNA1A, ATXN1, ATXN2, TBP, FGF14, AFG3L2, SCYL1, ELOVL5, SPTBN2, PPP2R2B, ELOVL4, ATXN3, NOP56, EEF2, ATXN7, TTBK2, ITPR1, ATXN8, PRKCG
intracellular membrane-bounded organelle (GO:0043231)	0.6	19	CACNA1A, ITPR1, ATXN2, TBP, SCYL1, AFG3L2, ATXN1, ELOVL5, SPTBN2, FGF14, PPP2R2B, ELOVL4, ATXN3, NOP56, EEF2, TTBK2, ATXN7, ATXN8, PRKCG
organelle (GO:0043226)	0.4	19	CACNA1A, ATXN1, ATXN2, TBP, FGF14, AFG3L2, SCYL1, ELOVL5, SPTBN2, PPP2R2B, ELOVL4, ATXN3, NOP56, EEF2, ATXN7, TTBK2, ITPR1, ATXN8, PRKCG
membrane part (GO:0044425)	0.95	16	CACNA1A, CACNA1G, ITPR1, BEAN1, ELOVL5, SCYL1, AFG3L2, KCNC3, TMEM240, SPTBN2, TRPC3, KCND3, EEF2, ATXN3, ELOVL4, PRKCG
intracellular organelle part (GO:0044446)	0.81	15	ITPR1, ATXN1, ATXN2, TBP, ELOVL5, AFG3L2, SCYL1, ELOVL4, SPTBN2, PPP2R2B, KCND3, NOP56, ATXN7, TTBK2, ATXN3
organelle part (GO:0044422)	0.79	15	ATXN1, ATXN2, TBP, ELOVL5, AFG3L2, SCYL1, ELOVL4, SPTBN2, PPP2R2B, KCND3, ATXN3, NOP56, ATXN7, TTBK2, ITPR1
cytoplasmic part (GO:0044444)	0.82	14	ATXN2, ELOVL5, AFG3L2, SCYL1, ELOVL4, SPTBN2, PPP2R2B, KCND3, ATXN3, EEF2, TTBK2, ITPR1, ATXN10, PRKCG
macromolecular complex (GO:0032991)	1.35	13	CACNA1A, PPP2R2B, ATXN1, ATXN2, TBP, SCYL1, KCNC3, CACNA1G, KCND3, NOP56, ATXN7, EEF2, ITPR1
nucleus (GO:0005634)	1.07	12	CACNA1A, ATXN1, TBP, FGF14, ATXN8, SCYL1, ATXN3, NOP56, TTBK2, ATXN7, EEF2, PRKCG
integral component of membrane (GO:0016021)	1.14	11	CACNA1A, TRPC3, ELOVL5, AFG3L2, KCNC3, TMEM240, CACNA1G, KCND3, ITPR1, ELOVL4, BEAN1
intrinsic component of membrane (GO:0031224)	1.13	11	CACNA1A, TRPC3, ELOVL5, AFG3L2, KCNC3, TMEM240, CACNA1G, KCND3, ITPR1, ELOVL4, BEAN1
plasma membrane (GO:0005886)	1.39	11	CACNA1A, TRPC3, KCNC3, TMEM240, SPTBN2, CACNA1G, KCND3, PDYN, ATXN10, EEF2, PRKCG
protein complex (GO:0043234)	1.51	10	CACNA1A, PPP2R2B, ITPR1, ATXN1, TBP, SCYL1, KCNC3, CACNA1G, KCND3, ATXN7
non-membrane-bounded organelle (GO:0043228)	1.76	9	ATXN2, ITPR1, SCYL1, SPTBN2, PPP2R2B, NOP56, TTBK2, ATXN7, EEF2
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	9	ATXN2, ITPR1, SCYL1, SPTBN2, PPP2R2B, NOP56, TTBK2, ATXN7, EEF2
neuron part (GO:0097458)	2.64	8	CACNA1A, KCND3, SPTBN2, ELOVL5, PDYN, ATXN10, ITPR1, PRKCG
plasma membrane part (GO:0044459)	1.95	8	CACNA1A, TRPC3, KCNC3, TMEM240, SPTBN2, CACNA1G, KCND3, PRKCG
cell projection (GO:0042995)	2.47	7	CACNA1A, KCND3, ELOVL5, PDYN, ATXN10, TTBK2, PRKCG
nuclear part (GO:0044428)	1.55	7	ATXN2, TBP, ITPR1, ATXN1, ATXN3, NOP56, ATXN7
cytosol (GO:0005829)	1.68	6	SPTBN2, EEF2, TTBK2, ATXN3, ATXN10, PRKCG
cell body (GO:0044297)	3.74	6	CACNA1A, ELOVL5, SPTBN2, KCND3, PDYN, ATXN10
dendrite (GO:0030425)	3.92	6	CACNA1A, KCND3, ELOVL5, PDYN, ATXN10, PRKCG
nucleoplasm (GO:0005654)	1.89	6	ATXN2, TBP, ATXN3, ATXN1, NOP56, ATXN7
neuron projection (GO:0043005)	3.12	6	CACNA1A, KCND3, ELOVL5, PDYN, ATXN10, PRKCG
neuronal cell body (GO:0043025)	3.9	6	CACNA1A, ELOVL5, SPTBN2, KCND3, PDYN, ATXN10
cytoskeleton (GO:0005856)	2.55	5	PPP2R2B, SCYL1, TTBK2, ATXN7, SPTBN2
endoplasmic reticulum part (GO:0044432)	2.73	5	ATXN3, KCND3, ITPR1, ELOVL4, ELOVL5
synapse part (GO:0044456)	3.42	5	CACNA1A, TMEM240, ITPR1, PRKCG, SPTBN2
organelle membrane (GO:0031090)	1.97	5	PPP2R2B, ITPR1, AFG3L2, ATXN3, SPTBN2
membrane protein complex (GO:0098796)	2.84	5	CACNA1A, CACNA1G, KCND3, KCNC3, SCYL1
transmembrane transporter complex (GO:1902495)	4.06	4	CACNA1A, CACNA1G, KCND3, KCNC3
transporter complex (GO:1990351)	4.04	4	CACNA1A, CACNA1G, KCND3, KCNC3
endoplasmic reticulum membrane (GO:0005789)	2.95	4	ATXN3, ELOVL4, ITPR1, ELOVL5
plasma membrane protein complex (GO:0098797)	3.55	4	CACNA1A, CACNA1G, KCND3, KCNC3
ion channel complex (GO:0034702)	4.18	4	CACNA1A, CACNA1G, KCND3, KCNC3
cation channel complex (GO:0034703)	4.69	4	CACNA1A, CACNA1G, KCND3, KCNC3
perinuclear region of cytoplasm (GO:0048471)	3.35	4	ATXN10, PRKCG, SPTBN2, ATXN2
extracellular region part (GO:0044421)	1.57	4	ATXN10, EEF2, TTBK2, SPTBN2
plasma membrane region (GO:0098590)	2.97	3	TMEM240, PRKCG, SPTBN2
endoplasmic reticulum (GO:0005783)	2.56	3	ELOVL4, ITPR1, ELOVL5
intracellular ribonucleoprotein complex (GO:0030529)	3.19	3	EEF2, NOP56, ATXN2
nucleolus (GO:0005730)	3.06	3	ITPR1, NOP56, ATXN7
extracellular space (GO:0005615)	2.63	3	TTBK2, ATXN10, SPTBN2
bounding membrane of organelle (GO:0098588)	2.39	3	PPP2R2B, ITPR1, SPTBN2
ribonucleoprotein complex (GO:1990904)	3.19	3	EEF2, NOP56, ATXN2
inclusion body (GO:0016234)	5.55	3	ATXN1, EEF2, ATXN3
mitochondrial membrane (GO:0031966)	3.31	3	PPP2R2B, AFG3L2, ATXN3
Golgi apparatus part (GO:0044431)	3.0	3	SCYL1, SPTBN2, ATXN2
cytoskeletal part (GO:0044430)	2.49	3	TTBK2, SCYL1, SPTBN2
nucleoplasm part (GO:0044451)	3.22	3	TBP, ATXN1, ATXN7
mitochondrial part (GO:0044429)	2.92	3	PPP2R2B, AFG3L2, ATXN3
nuclear matrix (GO:0016363)	5.22	3	ATXN1, ATXN3, ATXN7
cell junction (GO:0030054)	2.75	3	TMEM240, PRKCG, SPTBN2
catalytic complex (GO:1902494)	2.9	3	PPP2R2B, ITPR1, ATXN7
phosphatase complex (GO:1903293)	5.93	2	PPP2R2B, ITPR1
calcium channel complex (GO:0034704)	5.72	2	CACNA1A, CACNA1G
voltage-gated calcium channel complex (GO:0005891)	6.11	2	CACNA1A, CACNA1G
nuclear inclusion body (GO:0042405)	7.32	2	ATXN1, ATXN3
microtubule organizing center (GO:0005815)	3.42	2	TTBK2, SCYL1
intrinsic component of plasma membrane (GO:0031226)	2.53	2	TRPC3, KCND3
synaptic membrane (GO:0097060)	4.22	2	TMEM240, PRKCG
vesicle (GO:0031982)	1.64	2	EEF2, SPTBN2
whole membrane (GO:0098805)	2.85	2	PPP2R2B, ITPR1
mitochondrion (GO:0005739)	2.42	2	PPP2R2B, AFG3L2
membrane-bounded vesicle (GO:0031988)	1.71	2	EEF2, SPTBN2
cytoplasmic vesicle part (GO:0044433)	3.41	2	SCYL1, ITPR1
extracellular region (GO:0005576)	2.18	2	FGF14, PDYN
Golgi apparatus (GO:0005794)	2.7	2	SCYL1, ATXN2
protein serine/threonine phosphatase complex (GO:0008287)	5.93	2	PPP2R2B, ITPR1
voltage-gated potassium channel complex (GO:0008076)	5.34	2	KCND3, KCNC3
integral component of plasma membrane (GO:0005887)	2.57	2	TRPC3, KCND3
polysome (GO:0005844)	6.16	2	EEF2, ATXN2
cell projection part (GO:0044463)	2.97	2	TTBK2, PDYN
organelle inner membrane (GO:0019866)	3.56	2	AFG3L2, ITPR1
intracellular (GO:0005622)	2.37	2	FGF14, PRKCG
potassium channel complex (GO:0034705)	5.32	2	KCND3, KCNC3
synapse (GO:0045202)	3.58	2	TMEM240, PRKCG

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
transmembrane transporter complex (GO:1902495)	-	4.06	0.032	CACNA1A, KCNC3, CACNA1G, KCND3, ITPR1, PRKCG
endoplasmic reticulum (GO:0005783)	-	2.56	0.027	TRPC3, ATXN2, TBP, ATXN3, ATXN1, ELOVL5, CACNA1G, ELOVL4, NOP56, ITPR1, PRKCG
neuron part (GO:0097458)	-	2.64	0.048	CACNA1A, TRPC3, TBP, ATXN1, KCNC3, SPTBN2, CACNA1G, KCND3, PPP2R2B, ATXN10, EEF2, PRKCG
transporter complex (GO:1990351)	-	4.04	0.035	CACNA1A, KCNC3, CACNA1G, KCND3, ITPR1, PRKCG
cell projection part (GO:0044463)	-	2.97	0.034	TRPC3, ATXN1, ATXN2, TBP, SCYL1, KCNC3, SPTBN2, PPP2R2B, CACNA1G, NOP56, TTBK2
cell body (GO:0044297)	-	3.74	0.016	CACNA1A, TBP, ATXN1, SPTBN2, TRPC3, KCND3, ATXN10, PRKCG
endoplasmic reticulum part (GO:0044432)	-	2.73	0.015	ITPR1, TRPC3, TBP, ELOVL5, ATXN1, ELOVL4, SPTBN2, CACNA1G, KCND3, NOP56, ATXN3, PRKCG
calcium channel complex (GO:0034704)	-	5.72	0.025	CACNA1A, CACNA1G, ITPR1
neuronal cell body (GO:0043025)	-	3.9	0.006	CACNA1A, TBP, ATXN1, SPTBN2, TRPC3, KCND3, ATXN10, PRKCG
cation channel complex (GO:0034703)	-	4.69	0.008	CACNA1A, CACNA1G, KCND3, KCNC3, PRKCG
basal plasma membrane (GO:0009925)	NEW	6.34	0.047	TBP, TRPC3, PRKCG
perinuclear region of cytoplasm (GO:0048471)	-	3.35	0.004	CACNA1A, TRPC3, ATXN2, TBP, ATXN1, CACNA1G, NOP56, SCA7, EEF2, ATXN10, PRKCG
nuclear matrix (GO:0016363)	-	5.22	0.015	TBP, ATXN1, ATXN3, SCA7, ATXN2
plasma membrane part (GO:0044459)	-	1.95	0.012	CACNA1A, TRPC3, ATXN1, ATXN2, TBP, SCYL1, AFG3L2, KCNC3, SPTBN2, CACNA1G, KCND3, ATXN3, NOP56, PPP2R2B, EEF2, ITPR1, PRKCG